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  1. The prognosis of non-small-cell lung cancer (NSCLC) with brain metastases is very poor. Currently, therapeutic methods for this patient population include whole-brain radiation therapy (WBRT), surgery, radiosu...

    Authors: Kejun Liu, Guanming Jiang, Ailing Zhang, Zhuanghua Li and Jun Jia

    Citation: BMC Cancer 2020 20:76

    Content type: Research article

    Published on:

  2. Approximately 40% of colorectal cancer patients will develop colorectal liver metastases (CRLM). The most effective approach to increase long-term survival is CRLM complete resection. Unfortunately, only 10–15...

    Authors: Alice Boilève, Aline Maillard, Mathilde Wagner, Clarisse Dromain, Christophe Laurent, Eric Dupont Bierre, Samuel Le Sourd, Franck Audemar, Ayhan Ulusakarya, Veronique Guerin-Meyer, Denis Smisth, Veronica Pezzella, Thierry De Baere, Diane Goere, Maximiliano Gelli, Julien Taieb…

    Citation: BMC Cancer 2020 20:74

    Content type: Study protocol

    Published on:

  3. This study aimed to compare clinical outcomes following placement of fully covered self-expanding metallic stents (FCSEMS) vs partially covered self-expanding metallic stents (PCSEMS) for palliative treatment ...

    Authors: Chunmei Wang, Hua Wei and Yuxia Li

    Citation: BMC Cancer 2020 20:73

    Content type: Research article

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  4. Breast cancer (BC) is known to be the most common malignancy in females whereas colorectal cancer (CRC) incidence also higher in both genders in Sri Lanka. TP53 is an important tumour suppressor gene and its soma...

    Authors: Vahinipriya Manoharan, Eric Hamilton Karunanayake, Kamani Hemamala Tennekoon, Sumadee De Silva, Ahamed Ilyas Ahamed Imthikab, Kanishka De Silva, Preethika Angunawela, Sameera Vishwakula and John Lunec

    Citation: BMC Cancer 2020 20:72

    Content type: Research article

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  5. Kaposi’s sarcoma (KS) is one of the most common HIV-associated malignancies in sub-Saharan Africa. Worldwide, the availability of antiretroviral therapy (ART) has improved KS survival. In resource-rich setting...

    Authors: Esther E. Freeman, Naftali Busakhala, Susan Regan, Fredrick Chite Asirwa, Megan Wenger, Divya Seth, Khatiya Chelidze Moon, Aggrey Semeere, Toby Maurer, Kara Wools-Kaloustian, Ingrid Bassett and Jeffrey Martin

    Citation: BMC Cancer 2020 20:71

    Content type: Research article

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  6. Second primary cancer of the esophagus is frequent in head and neck patients, especially in high-risk populations, and has a great impact on the prognosis. Although Positron emission tomography (PET)/computed ...

    Authors: Hsuan-An Su, Shun-Wen Hsiao, Yu-Chun Hsu, Lien-Yen Wang and Hsu-Heng Yen

    Citation: BMC Cancer 2020 20:69

    Content type: Research article

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  7. The antibody targeting platelet-derived growth factor receptor alpha (PDGFRA), olaratumab, was approved in 2016 for metastatic soft tissue sarcoma (STS) in combination with doxorubicin based on promising resul...

    Authors: Jana Käthe Striefler, Franziska Brandes, Alexander Baur, Berit Maria Pfitzner, David Kaul, Daniel Rau, Anne Dörr, Maren Schmiester, Georgios Koulaxouzidis, Lars Bullinger, Sven Märdian and Anne Flörcken

    Citation: BMC Cancer 2020 20:68

    Content type: Research article

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  8. We previously reported that tamoxifen (TAM)-induced ovarian hyperstimulation (OHS) is associated with high serum concentrations of estradiol in premenopausal women with breast cancer. To investigate risk facto...

    Authors: Rena Yamazaki, Masafumi Inokuchi, Satoko Ishikawa, Takuya Ayabe, Hiromitsu Jinno, Takashi Iizuka, Masanori Ono, Subaru Myojo, Soko Uchida, Toshiya Matsuzaki, Akira Tangoku, Masato Kita, Tomoharu Sugie and Hiroshi Fujiwara

    Citation: BMC Cancer 2020 20:67

    Content type: Research article

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  9. We sought to construct the optimal neurocognitive function (NCF) change criteria sensitive to health-related quality of life (HR-QOL) in patients who have undergone whole-brain radiation therapy (WBRT) for bra...

    Authors: Toshimichi Nakano, Hidefumi Aoyama, Hirotake Saito, Satoshi Tanabe, Kensuke Tanaka, Katsuya Maruyama, Tomoya Oshikane, Atsushi Ohta, Eisuke Abe and Motoki Kaidu

    Citation: BMC Cancer 2020 20:66

    Content type: Research article

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  10. Osteosarcoma is a primary malignant tumor originating from mesenchymal tissue, with a poor distant metastasis prognosis. The molecular mechanisms of osteosarcoma metastasis are extremely complicated.

    Authors: Mi Li, Xin Jin, Hao Li, Gang Wu, Shanshan Wang, Caihong Yang and Sisi Deng

    Citation: BMC Cancer 2020 20:65

    Content type: Research article

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  11. It is still difficult to detect and diagnose early adenocarcinoma of the esophagogastric junction (EGJ) using conventional endoscopy or image-enhanced endoscopy. A glutamylprolyl hydroxymethyl rhodamine green ...

    Authors: Keiko Yamamoto, Shunsuke Ohnishi, Takeshi Mizushima, Junichi Kodaira, Masayoshi Ono, Yutaka Hatanaka, Kanako C. Hatanaka, Yugo Kuriki, Mako Kamiya, Nobuyuki Ehira, Keisuke Shinada, Hiroaki Takahashi, Yuichi Shimizu, Yasuteru Urano and Naoya Sakamoto

    Citation: BMC Cancer 2020 20:64

    Content type: Research article

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  12. Cervical cancer is the most common cancer and the leading cause of cancer death among women in Tanzania. Knowledge of and willingness to receive a cervical cancer screening are important determinants of preven...

    Authors: Qiao Weng, Jie Jiang, Fatma Mrisho Haji, Lamlet Hassan Nondo and Huaijun Zhou

    Citation: BMC Cancer 2020 20:63

    Content type: Research article

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  13. Overexpression of FAT1 gene and its oncogenic effects have been reported in several cancers. Previously, we have documented upregulation of FAT1 gene in glioblastoma (GBM) tumors which was found to increase th...

    Authors: Chitrangda Srivastava, Khushboo Irshad, Yakhlesh Gupta, Chitra Sarkar, Ashish Suri, Parthaprasad Chattopadhyay, Subrata Sinha and Kunzang Chosdol

    Citation: BMC Cancer 2020 20:62

    Content type: Research article

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  14. To explore the influencing factors of perioperative renal function change and their relationship with prognosis on renal cell carcinoma (RCC) patients with tumor thrombus after nephrectomy and thrombectomy.

    Authors: Zhuo Liu, Shiying Tang, Xiaojun Tian, Hongxian Zhang, Guoliang Wang, Shudong Zhang and Lulin Ma

    Citation: BMC Cancer 2020 20:61

    Content type: Research article

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  15. The value of the CT features and quantitative analysis of lung subsolid nodules (SSNs) in the prediction of the pathological grading of lung adenocarcinoma is discussed.

    Authors: Xiaohu Li, Wei Zhang, Yongqiang Yu, Guihong Zhang, Lifen Zhou, Zongshan Wu and Bin Liu

    Citation: BMC Cancer 2020 20:60

    Content type: Research article

    Published on:

  16. This study aimed to evaluate the safety and feasibility of self-expanding metallic stent (SEMS) followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer.

    Authors: Jia Gang Han, Zhen Jun Wang, Wei Gen Zeng, Yan Bin Wang, Guang Hui Wei, Zhi Wei Zhai, Bao Cheng Zhao and Bing Qiang Yi

    Citation: BMC Cancer 2020 20:57

    Content type: Research article

    Published on:

  17. The presence of comorbidity affects the care of cancer patients, many of whom are living with multiple comorbidities. The prevalence of cancer comorbidity, beyond summary metrics, is not well known. This study...

    Authors: Helen Fowler, Aurelien Belot, Libby Ellis, Camille Maringe, Miguel Angel Luque-Fernandez, Edmund Njeru Njagi, Neal Navani, Diana Sarfati and Bernard Rachet

    Citation: BMC Cancer 2020 20:2

    Content type: Research article

    Published on:

  18. Lung adenocarcinoma (LUAD) is one of the most common cancer types, threatening the human health around the world. However, the high heterogeneity and complexity of LUAD limit the benefits of targeted therapies...

    Authors: Zhenyang Lv and Ting Lei

    Citation: BMC Cancer 2020 20:56

    Content type: Research article

    Published on:

  19. Following publication of the original article [1], the authors reported an error in Fig. 6c and in the figure legends for Fig. 5c and Fig. 6c.

    Authors: Gisela Nilsson and Marie Kannius-Janson

    Citation: BMC Cancer 2020 20:55

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2016 16:142

  20. Hepatocellular carcinoma (HCC) with hilar bile duct tumor thrombus (HBDTT) often mimic hilar cholangiocarcinoma (hilar CC). The purpose of this study is to analyze the Computed Tomography (CT) characteristics ...

    Authors: Xiaoqi Zhou, Jifei Wang, Mimi Tang, Mengqi Huang, Ling Xu, Zhenpeng Peng, Zi-Ping Li and Shi-Ting Feng

    Citation: BMC Cancer 2020 20:54

    Content type: Research article

    Published on:

  21. Study aimed to characterise treatment and outcomes for patients with hormone receptor positive (HR+), human epidermal growth factor 2 negative (HER2-) metastatic breast cancer (MBC) within a large regional can...

    Authors: Chris Twelves, Sue Cheeseman, Will Sopwith, Matthew Thompson, Majid Riaz, Necibe Ahat-Donker, Melissa Myland, Adam Lee, Raymond Przybysz, Stuart Turner, Geoff Hall and Tim Perren

    Citation: BMC Cancer 2020 20:53

    Content type: Research article

    Published on:

  22. The incidence of anal cancer is rising in the last decades and more women are affected than men. The prognosis after chemoradiation is very good with complete remission rates of 80–90%. Thus, reducing therapy-...

    Authors: Nathalie Arians, Matthias Häfner, Johannes Krisam, Kristin Lang, Antje Wark, Stefan A. Koerber, Adriane Hommertgen and Jürgen Debus

    Citation: BMC Cancer 2020 20:52

    Content type: Study protocol

    Published on:

  23. More people than ever before are currently living with a diagnosis of cancer and the number of people concerned is likely to continue to rise. Cancer survivors are at risk of developing a second primary cancer...

    Authors: Anita Feller, Katarina L. Matthes, Andrea Bordoni, Christine Bouchardy, Jean-Luc Bulliard, Christian Herrmann, Isabelle Konzelmann, Manuela Maspoli, Mohsen Mousavi, Sabine Rohrmann, Katharina Staehelin and Volker Arndt

    Citation: BMC Cancer 2020 20:51

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:87

  24. Screening for and active management of comorbidity soon after cancer diagnosis shows promise in altering cancer treatment and outcomes for comorbid patients. Prior to a large multi-centre study, piloting of th...

    Authors: Virginia Signal, Christopher Jackson, Louise Signal, Claire Hardie, Kirsten Holst, Marie McLaughlin, Courtney Steele and Diana Sarfati

    Citation: BMC Cancer 2020 20:50

    Content type: Research article

    Published on:

  25. Preoperative chemoradiotherapy is the recommended standard of care for patients with local advanced rectal cancer. However, it remains unclear, whether a prolonged time interval to surgery results in an increa...

    Authors: Sven Lichthardt, Johanna Wagner, Stefan Löb, Niels Matthes, Caroline Kastner, Friedrich Anger, Christoph-Thomas Germer and Armin Wiegering

    Citation: BMC Cancer 2020 20:49

    Content type: Research article

    Published on:

  26. Leukemia is the most common cancer in childhood. The estimated incidence rate of childhood leukemia in Colombia is one of the highest in America and little is known about its spatial distribution.

    Authors: Laura Andrea Rodriguez-Villamizar, Marcela Pilar Rojas Díaz, Lizbeth Alexandra Acuña Merchán, Feisar Enrique Moreno-Corzo and Paula Ramírez-Barbosa

    Citation: BMC Cancer 2020 20:48

    Content type: Research article

    Published on:

  27. Glioblastoma (GBM) is a highly malignant brain neoplasm with poor survival. Despite its aggressive nature, metastatic spread of GBM is identified only rarely. While the molecular alterations associated with GB...

    Authors: Melissa Umphlett, Stephanie Shea, Jessica Tome-Garcia, Yizhou Zhang, Adilia Hormigo, Mary Fowkes, Nadejda M. Tsankova and Raymund L. Yong

    Citation: BMC Cancer 2020 20:47

    Content type: Case report

    Published on:

  28. Breast (BCa) and prostate (PCa) cancers are hormone receptor (HR)-driven cancers. Thus, BCa and PCa patients are given therapies that reduce hormone levels or directly block HR activity; but most patients even...

    Authors: Afshan F. Nawas, Mohammed Kanchwala, Shayna E. Thomas-Jardin, Haley Dahl, Kelly Daescu, Monica Bautista, Vanessa Anunobi, Ally Wong, Rachel Meade, Ragini Mistry, Nisha Ghatwai, Felix Bayerl, Chao Xing and Nikki A. Delk

    Citation: BMC Cancer 2020 20:46

    Content type: Research article

    Published on:

  29. Pancreatic cancer is a highly malignant tumor of the digestive system. This secretome of pancreatic cancer is key to its progression and metastasis. But different methods of protein extraction affect the final...

    Authors: Peng Liu, Lingming Kong, Keke Liang, Yunhao Wu, Haoyi Jin, Bing Song and Xiaodong Tan

    Citation: BMC Cancer 2020 20:45

    Content type: Research article

    Published on:

  30. The aim of this retrospective study was to compare the feasibility and efficiency of ultrasound-guided percutaneous microwave ablation (US-PMWA) assisted by three-dimensional visualization ablation planning sy...

    Authors: Chao An, Xin Li, Min Zhang, Jian Yang, Zhigang Cheng, Xiaoling Yu, Zhiyu Han, Fangyi Liu, Linan Dong, Jie Yu and Ping Liang

    Citation: BMC Cancer 2020 20:44

    Content type: Research article

    Published on:

  31. Following publication of the original article [1], the authors reported the errors in Fig. 1C and D, Fig. 2, Fig. 4B and C and Fig. 6D and E.

    Authors: Yanan Jiang, Jing Zhang, Jimin Zhao, Zhenzhen Li, Hanyong Chen, Yan Qiao, Xinhuan Chen, Kangdong Liu and Ziming Dong

    Citation: BMC Cancer 2020 20:43

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2019 19:1264

  32. Following publication of the original article [1], the authors reported an error in Fig 5 of this article, graphs presenting FCM and immunofluorescent for CD4T, CD8T and NK cell of the Control Groups (LL2, LL2...

    Authors: Hongwei Tian, Gang Shi, Guoyou Yang, Junfeng Zhang, Yiming Li, Tao Du, Jianzhou Wang, Fen Xu, Lin Cheng, Xiaomei Zhang, Lei Dai, Xiaolei Chen, Shuang Zhang, Yang Yang, Dechao Yu, Yuquan Wei…

    Citation: BMC Cancer 2020 20:42

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2014 14:48

  33. There is increasing recognition that PROs are important in the estimation of the burden of long-term survival among patients with gastric cancer. The study aimed to develop a disease-specific instrument to ass...

    Authors: Xiaojuan Hu, Fen Zhao, Hongmei Yu, Yanhong Luo, Jinchun Liu and Yanbo Zhang

    Citation: BMC Cancer 2020 20:41

    Content type: Research article

    Published on:

  34. This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate the potential of 10 specific circRNAs as diagnostic and prognostic biomarkers in multiple myelom...

    Authors: Fan Zhou, Dongjiao Wang, Wei Wei, Haimin Chen, Haotian Shi, Nian Zhou, Lixia Wu and Rong Peng

    Citation: BMC Cancer 2020 20:40

    Content type: Research article

    Published on:

  35. Optimal therapy for colorectal carcinoma (CRC), a frequently diagnosed malignancy, does not exist. Some of colicins and microcins, ribosomally synthesized peptides by gramnegative bacteria, have shown signific...

    Authors: Darina Kohoutova, Miroslava Forstlova, Paula Moravkova, Jiri Cyrany, Juraj Bosak, David Smajs, Stanislav Rejchrt and Jan Bures

    Citation: BMC Cancer 2020 20:39

    Content type: Research article

    Published on:

  36. Pancreatic adenosquamous carcinoma has a poor prognosis, with limited prospective trial data to guide optimal treatment. The potential impact of drug metabolism on the treatment response of patients with pancr...

    Authors: Claire M. Connell, Rebecca Brais, Hayley Whitaker, Sara Upponi, Ian Beh, Jane Risdall, Pippa Corrie, Tobias Janowitz and Duncan I. Jodrell

    Citation: BMC Cancer 2020 20:38

    Content type: Case report

    Published on:

  37. Intratumoral heterogeneity has an enormous effect on patient treatment and outcome. The purpose of the current study was to establish and validate a nomogram with intratumoral heterogeneity derived from 18F-fluor...

    Authors: Bingxin Gu, Jianping Zhang, Guang Ma, Shaoli Song, Liqun Shi, Yingjian Zhang and Zhongyi Yang

    Citation: BMC Cancer 2020 20:37

    Content type: Research article

    Published on:

  38. The aim of the present study was to assess the efficacy of concurrent chemoradiotherapy (CRT) or radiotherapy alone (RT-alone) in elderly patients with esophageal squamous cell carcinoma (ESCC).

    Authors: Mingqiu Chen, Xiaohong Liu, Chun Han, Xin Wang, Yidian Zhao, Qingsong Pang, Xinchen Sun, Gaofeng Li, Kaixian Zhang, Ling Li, Xueying Qiao, Yu Lin, Junqiang Chen and Zefen Xiao

    Citation: BMC Cancer 2020 20:36

    Content type: Research article

    Published on:

  39. The prognosis of glioma is poor, despite recent advances in diagnosis and treatment of the disease. It is important to investigate the clinical characteristics and prognostic factors of glioma so as to provide...

    Authors: Jianfeng Liang, Xiaomin Lv, Changyu Lu, Xun Ye, Xiaolin Chen, Jia Fu, Chenghua Luo and Yuanli Zhao

    Citation: BMC Cancer 2020 20:35

    Content type: Research article

    Published on:

  40. Gastric cancer (GC) is a leading cause of cancer death, occurs predominantly in older age, with increasing incidence in young patients. The Cancer Genome Atlas indicates four subtypes for GC among which Epstei...

    Authors: Assaf Moore, Elad Hikri, Tal Goshen-Lago, Tamar Barkan, Sara Morgenstern, Elena Brook, Annett Maderer, Wilfried Roth, Noa Gordon, Hanoch Kashtan, Baruch Brenner, Markus Moehler and Irit Ben Aharon

    Citation: BMC Cancer 2020 20:34

    Content type: Research article

    Published on:

  41. Matrix metalloproteinase 7 (MMP7), as the smallest member of the matrix metalloproteinase family, has been verified to be implicated in cancer progression, especially metastasis. However, its expression patter...

    Authors: Shuo Yuan, Li-song Lin, Rui-Huan Gan, Li Huang, Xiao-ting Wu, Yong Zhao, Bo-hua Su, Dali Zheng and You-Guang Lu

    Citation: BMC Cancer 2020 20:33

    Content type: Research article

    Published on:

  42. Vasculogenic mimicry (VM), defined as a capability of aggressive tumor Cells to mimic embryonic vasculogenic networks, caused poor prognosis in hepatocellular carcinoma (HCC). Rho kinases (ROCK), p21-activated...

    Authors: Ji-Gang Zhang, He-Ming Zhou, Xue Zhang, Wan Mu, Juan-Ni Hu, Gao-Lin Liu and Qin Li

    Citation: BMC Cancer 2020 20:32

    Content type: Research article

    Published on:

  43. Chemo-resistance in hepatocellular carcinoma (HCC) is a major problem, and acquired drug resistance prevents cancer therapies from achieving complete responses. Molecular targeting therapy presents an opportun...

    Authors: Xia Liao, Ge Song, Zihan Xu, Yang Bu, Fan Chang, Fengan Jia, Xuelian Xiao, Xuejiao Ren, Mei Zhang and Qingan Jia

    Citation: BMC Cancer 2020 20:31

    Content type: Research article

    Published on:

  44. Childhood cancers represent a small proportion of all cancers but are still a major public health problem. The study analysed long-term trends in childhood cancer incidence and survival in Estonia in relation ...

    Authors: Keiu Paapsi, Aleksei Baburin, Sirje Mikkel, Margit Mägi, Kadri Saks and Kaire Innos

    Citation: BMC Cancer 2020 20:30

    Content type: Research article

    Published on:

  45. To evaluate radiomics analysis in neuro-oncologic studies according to a radiomics quality score (RQS) system to find room for improvement in clinical use.

    Authors: Ji Eun Park, Ho Sung Kim, Donghyun Kim, Seo Young Park, Jung Youn Kim, Se Jin Cho and Jeong Hoon Kim

    Citation: BMC Cancer 2020 20:29

    Content type: Research article

    Published on:

  46. Pyroptosis belongs to a novel inflammatory programmed cell death pathway, with the possible prognosis of endometrial cancer related to the terminal protein GSDMD. Hydrogen exerts a biphasic effect on cancer by...

    Authors: Ye Yang, Ping Yin Liu, Wei Bao, Song Jun Chen, Fang Su Wu and Ping Ya Zhu

    Citation: BMC Cancer 2020 20:28

    Content type: Research article

    Published on:

  47. High grade gastroenteropancreatic (GEP) neuroendocrine neoplasms (NEN) with a Ki67 proliferation index > 20%, include well-differentiated tumours grade 3 (NET G3) and poorly differentiated (PD) neuroendocrine ...

    Authors: Kirstine Nielsen, Tina Binderup, Seppo W. Langer, Andreas Kjaer, Pauline Knigge, Veronica Grøndahl, Linea Melchior, Birgitte Federspiel and Ulrich Knigge

    Citation: BMC Cancer 2020 20:27

    Content type: Research article

    Published on:

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