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  2. Saskatchewan has one of the highest incidence of prostate cancer (PCa) in Canada. This study assesses if geographic factors in Saskatchewan, including location of where patients live and physician density are ...

    Authors: Mustafa Andkhoie and Michael Szafron

    Citation: BMC Cancer 2021 21:948

    Content type: Research article

    Published on:

  3. Although chemotherapy for metastatic colorectal cancer (mCRC) has improved, the standard chemotherapy regimens for patients with RAS wild-type mCRC remain debated. This study aimed to compare S-1 and oxaliplat...

    Authors: Yujiro Nishizawa, Naotsugu Haraguchi, Hirotoshi Kim, Yoshihito Ide, Ken Nakata, Shu Okamura, Toshihiro Kudo, Taroh Satoh, Mamoru Uemura, Chu Matsuda, Tsunekazu Mizushima, Kohei Murata, Yuichiro Doki and Hidetoshi Eguchi

    Citation: BMC Cancer 2021 21:947

    Content type: Research article

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  4. In patients with average risk of bleeding, second-look endoscopy does not reportedly reduce bleeding after gastric endoscopic submucosal dissection. However, effectiveness of second-look endoscopy for patients...

    Authors: Takeshi Uozumi, Tetsuya Sumiyoshi, Yusuke Tomita, Kaho Tokuchi, Hiroya Sakano, Masahiro Yoshida, Ryoji Fujii, Takeyoshi Minagawa, Yutaka Okagawa, Kotaro Morita, Kei Yane, Hideyuki Ihara, Michiaki Hirayama and Hitoshi Kondo

    Citation: BMC Cancer 2021 21:946

    Content type: Research article

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  5. Genomic profiles of specific gene sets have been established to guide personalized treatment and prognosis for patients with breast cancer (BC). However, epigenomic information has not yet been applied in a cl...

    Authors: Yang-Hong Dai, Ying-Fu Wang, Po-Chien Shen, Cheng-Hsiang Lo, Jen-Fu Yang, Chun-Shu Lin, Hsing-Lung Chao and Wen-Yen Huang

    Citation: BMC Cancer 2021 21:945

    Content type: Research article

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  6. Proton beam therapy (PBT) is a new-emerging cancer treatment in China but its treatment costs are high and not yet covered by Chinese public medical insurance. The advanced form of PBT, intensity-modulated pro...

    Authors: Guo Li, Yun-Fei Xia, Yi-Xiang Huang, Deniz Okat, Bo Qiu, Jerome Doyen, Pierre-Yves Bondiau, Karen Benezery, Jin Gao and Chao-Nan Qian

    Citation: BMC Cancer 2021 21:944

    Content type: Research article

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  7. The effective treatment and prognosis prediction of bladder cancer (BLCA) remains a medical problem. Ferroptosis is an iron-dependent form of programmed cell death. Ferroptosis is closely related to tumour occ...

    Authors: Yingchun Liang, Fangdie Ye, Chenyang Xu, Lujia Zou, Yun Hu, Jimeng Hu and Haowen Jiang

    Citation: BMC Cancer 2021 21:943

    Content type: Research

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  8. The prognostic nutritional index (PNI) reflects immunonutritional status. We evaluated the effects of postoperative PNI and perioperative changes in the PNI on overall survival (OS) in glioblastoma (GBM) patie...

    Authors: Yoon Jung Kim, Hyongmin Oh, Sang Jin Lee, Kyung-Min Kim, Ho Kang, Chul-Kee Park and Hee-Pyoung Park

    Citation: BMC Cancer 2021 21:942

    Content type: Research

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  9. It is known that one of the reasons for the increased incidence of hematological malignancies is caused by the growth of multiple myeloma (MM). Worldwide, approximately 159,985 new cases of MM are diagnosed re...

    Authors: Narine Ghazaryan, Samvel Danelyan, Samvel Bardakhchyan, Anahit Saharyan and Lusine Sahakyan

    Citation: BMC Cancer 2021 21:941

    Content type: Research article

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  10. Radiation therapy (RT) plays a key role in curative-intent treatment for locally advanced lung cancer. Radiation induced pulmonary toxicity can be significant for some patients and becomes a limiting factor fo...

    Authors: Azza Ahmed Khalil, Eric Hau, Val Gebski, Cai Grau, Harriet Gee, Tine Bisballe Nyeng, Katrina West, Stine Kramer, David Farlow, Marianne Knap, Ditte Sloth Møller, Lone Hoffmann and Katherina P. Farr

    Citation: BMC Cancer 2021 21:940

    Content type: Study protocol

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  11. Microparticles (MPs) are extracellular vesicles that are associated with cancer development and progression. Advanced non-small cell lung cancer (NSCLC) still shows disease progression after multiple lines of ...

    Authors: Tingting Liu, Jiang Wang, Tao Li, Pengfei Cui, Baicun Hou, Chunxiao Zhuang, Ge Wei, Sujie Zhang, Hongxia Li and Yi Hu

    Citation: BMC Cancer 2021 21:939

    Content type: Research

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  12. Lung adenocarcinoma (LUAD) is a major subtype of lung cancer and closely associated with poor prognosis. N6-methyladenosine (m6A), one of the most predominant modifications in mRNAs, is found to participate in...

    Authors: Hao Zhou, Miaosen Zheng, Muqi Shi, Jinjie Wang, Zhanghao Huang, Haijian Zhang, Youlang Zhou and Jiahai Shi

    Citation: BMC Cancer 2021 21:938

    Content type: Research

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  14. Among patients with non-metastatic pancreatic cancer, 80% have high-risk, borderline resectable or locally advanced cancer, with a 5-year overall survival of 12%. MASTERPLAN evaluates the safety and activity o...

    Authors: Andrew Oar, Mark Lee, Hien Le, Kate Wilson, Chris Aiken, Lorraine Chantrill, John Simes, Nam Nguyen, Andrew Barbour, Jaswinder Samra, Katrin M. Sjoquist, Alisha Moore, David Espinoza, Val Gebski, Sonia Yip, Julie Chu…

    Citation: BMC Cancer 2021 21:936

    Content type: Study protocol

    Published on:

  15. Cervical cancer incidence is influenced by screening and risk factors in the population. The main risk factor for cervical cancer is sexually transmitted human papillomavirus (HPV), which is sexually transmitt...

    Authors: Bo T. Hansen, Suzanne Campbell and Mari Nygård

    Citation: BMC Cancer 2021 21:935

    Content type: Research

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  16. The human microbiome is defined as the microorganisms that reside in or on the human body, such as bacteria, viruses, fungi, and protozoa, and their genomes. The human microbiome participates in the modulation...

    Authors: Zi-Kun Yu, Rui-Ling Xie, Rui You, You-Ping Liu, Xu-Yin Chen, Ming-Yuan Chen and Pei-Yu Huang

    Citation: BMC Cancer 2021 21:934

    Content type: Review

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  18. Doublet chemotherapy in combination with a biologic agent has been a standard of care in patients with metastatic colorectal cancer for over a decade. The evidence for a “lighter” treatment approach is limited...

    Authors: Ho Wai Derrick Siu, Niall Tebbutt, Lorraine Chantrill, Chris Karapetis, Christopher Steer, Kate Wilson, David Espinoza, Lisa Bailey, Sonia Yip, Jeff Cuff, Nick Pavlakis, Subotheni Thavaneswaran, Karen Briscoe, Ratnesh Srivastav, Jennifer Shannon, Eva Segelov…

    Citation: BMC Cancer 2021 21:932

    Content type: Study protocol

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  19. The mechanisms of endocrine resistance are complex, and deregulation of several oncogenic signalling pathways has been proposed. We aimed to investigate the role of the EGFR and Src-mediated STAT3 signalling p...

    Authors: Seo Yun Moon, Heejin Lee, Seoree Kim, Ji Hyung Hong, Sang Hoon Chun, Hee Yeon Lee, Keunsoo Kang, Ho Shik Kim, Hye Sung Won and Yoon Ho Ko

    Citation: BMC Cancer 2021 21:931

    Content type: Research article

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  20. Colorectal cancer (CRC) screening reduces CRC incidence and mortality. However, current screening methods are either hampered by invasiveness or suboptimal performance, limiting their effectiveness as primary ...

    Authors: Ane Sørlie Kværner, Einar Birkeland, Cecilie Bucher-Johannessen, Elina Vinberg, Jan Inge Nordby, Harri Kangas, Vahid Bemanian, Pekka Ellonen, Edoardo Botteri, Erik Natvig, Torbjørn Rognes, Eivind Hovig, Robert Lyle, Ole Herman Ambur, Willem M. de Vos, Scott Bultman…

    Citation: BMC Cancer 2021 21:930

    Content type: Study protocol

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  21. To assess the effects of Epstein–Barr virus (EBV) and human papillomavirus (HPV) infection on the tumor microenvironment, we examined the relationship between viral infection status, macrophage migration inhib...

    Authors: Guofei Feng, Yifei Xu, Ning Ma, Kaoru Midorikawa, Shinji Oikawa, Hatasu Kobayashi, Satoshi Nakamura, Hajime Ishinaga, Zhe Zhang, Guangwu Huang, Kazuhiko Takeuchi and Mariko Murata

    Citation: BMC Cancer 2021 21:929

    Content type: Research

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  22. As major regulators of DNA replication in eukaryotes, minichromosome maintenance (MCM) proteins play an important role in the initiation and extension of DNA replication. MCMs and their related genes may be ne...

    Authors: Baojie Wu and Shuyi Xi

    Citation: BMC Cancer 2021 21:928

    Content type: Research

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  24. This study aimed to evaluate the possible role of human papillomavirus (HPV) and Epstein–Barr virus (EBV) coinfection as an etiological factor for prostate cancer (PCa) development.

    Authors: Javid Sadri Nahand, Khadijeh Khanaliha, Hamed Mirzaei, Mohsen Moghoofei, Hossein Bannazadeh Baghi, Maryam Esghaei, Ali Reza Khatami, Maryam Fatemipour and Farah Bokharaei-Salim

    Citation: BMC Cancer 2021 21:926

    Content type: Research

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  25. The aim of this study was to analyze the frequencies of genotypes and alleles of Single Nucleotide Polymorphism (SNP) LEP-R c.668A>G (p.Gln223Arg, rs1137101) of leptin receptor gene and to assess the influence th...

    Authors: Jan Bieńkiewicz, Hanna Romanowicz, Miłosz Wilczyński, Grzegorz Jabłoński, Anna Stepowicz, Anna Obłękowska, Andrzej Malinowski and Beata Smolarz

    Citation: BMC Cancer 2021 21:925

    Content type: Research

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  26. Nivolumab, an anti-programmed death 1 (PD-1) monoclonal antibody, has shown survival benefit in clinical trials of various malignant tumors. Nivolumab-induced pneumonitis is major immune-related adverse event ...

    Authors: Teppei Yamaguchi, Junichi Shimizu, Takaaki Hasegawa, Yoshitsugu Horio, Yoshitaka Inaba, Nobuhiro Hanai, Kei Muro and Toyoaki Hida

    Citation: BMC Cancer 2021 21:924

    Content type: Research article

    Published on:

  27. Gastric cancer (GC) is one of the leading causes of cancer-related deaths worldwide. Human epidermal growth factor receptor 2 (HER2) amplification occurs in approximately 13–23% of all GC cases and patients wi...

    Authors: Gang Ning, Qihui Zhu, Wonyoung Kang, Hamin Lee, Leigh Maher, Yun-Suhk Suh, Michael Michaud, Mayerlin Silva, Jee Young Kwon, Chengsheng Zhang and Charles Lee

    Citation: BMC Cancer 2021 21:923

    Content type: Research

    Published on:

  28. Tongue and mouth floor squamous cell carcinoma (T/MF SCC) exhibits a high rate of local recurrence and cervical lymph node metastasis. The effect of the tumor microenvironment on T/MF SCC remains unclear.

    Authors: Xuejie Li, Zheqi Liu, Wenkai Zhou, Xiaofang Liu and Wei Cao

    Citation: BMC Cancer 2021 21:922

    Content type: Research

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  30. Breast cancer (BC) is the most frequent female cancer and preferentially metastasizes to bone. The transcription factor TGFB-induced factor homeobox 1 (TGIF) is involved in bone metabolism. However, it is not ...

    Authors: Christine Stürken, Volker Möbus, Karin Milde-Langosch, Sabine Schmatloch, Peter A. Fasching, Josef Rüschoff, Elmar Stickeler, Rolf-Peter Henke, Carsten Denkert, Lars Hanker, Christian Schem, Valentina Vladimirova, Thomas Karn, Valentina Nekljudova, Claus-Henning Köhne, Frederik Marmé…

    Citation: BMC Cancer 2021 21:920

    Content type: Research

    Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:1024

  31. To assess the efficacies and potential predictors of a corticosteroid switch in metastatic castration-resistant prostate cancer (mCRPC) patients with biochemical progression on abiraterone acetate plus prednis...

    Authors: Zhenyu Yang, Yuchao Ni, Diwei Zhao, Yijun Zhang, Jun Wang, Lijuan Jiang, Dong Chen, Zhiming Wu, Yanjun Wang, Liru He, Yanxia Shi, Fangjian Zhou, Hao Zeng and Yonghong Li

    Citation: BMC Cancer 2021 21:919

    Content type: Research

    Published on:

  32. Breast cancer (BC) is a complex disease with high heterogeneity, which often leads to great differences in treatment results. Current common molecular typing method is PAM50, which shows positive results for p...

    Authors: Yan Zhang, Denan Zhang, Qingkang Meng, Ziqi Liu, Hongbo Xie, Lei Liu, Fei Xu and Xiujie Chen

    Citation: BMC Cancer 2021 21:918

    Content type: Research

    Published on:

  33. Lung cancer is the most common oncological cause of death in the Western world. Early diagnosis is critical for successful treatment. However, no effective screening methods exist. A promising approach could b...

    Authors: Charlotte Feil, Frank Staib, Martin R. Berger, Thorsten Stein, Irene Schmidtmann, Andreas Forster and Carl C. Schimanski

    Citation: BMC Cancer 2021 21:917

    Content type: Research

    Published on:

  34. Acute Limb Ischemia (ALI) carries a high morbidity and mortality rate that is compounded in the cancer patient. Though it is a relatively uncommon event, it is of extremely high adverse impact and carries poor...

    Authors: Yolanda Bryce, Amoateng Emmanuel Jr, Christopher Agrusa, Etay Ziv, Christopher Harnain, Samantha Huq and Ernesto Santos Martin

    Citation: BMC Cancer 2021 21:916

    Content type: Research

    Published on:

  35. Intracranial hemangiopericytoma is a rare disease and surgery is the mainstay treatment. Although postoperative adjuvant radiotherapy is often used, there are no reports comparing different radiotherapy techni...

    Authors: Jianbiao Xiao, Lanwei Xu, Yi Ding, Wei Wang, Fen Chen, Yangshu Zhou, Fengjiao Zhang, Qiyuan Zhou, Xuehui Wu, Junpeng Li, Li Liang and Yee-Min Jen

    Citation: BMC Cancer 2021 21:915

    Content type: Research article

    Published on:

  37. Although spread through air spaces (STAS) is a robust biomarker in surgically resected lung cancer, its application to biopsies is challenging. Moreover, limited resection is not an effective treatment for STA...

    Authors: Lanqing Cao, Meng Jia, Ping-Li Sun and Hongwen Gao

    Citation: BMC Cancer 2021 21:913

    Content type: Research article

    Published on:

  38. Intake time of diet has recently been demonstrated to be associated with the internal clock and circadian pattern. However, whether and how the intake time of minerals would influence the natural course of can...

    Authors: Xiaoqing Xu, Wei Wei, Jiaxu Xu, Jiaxin Huang, Li Li, Tianshu Han, Jiayue Qi, Changhao Sun, Ying Li and Wenbo Jiang

    Citation: BMC Cancer 2021 21:912

    Content type: Research article

    Published on:

  39. Total mesorectal excision (TME) and lateral lymph node dissection (LLND) without radiotherapy (RT) are standard treatment for lower cT3/4 rectal cancers in Eastern countries. In comparative studies, both TME +...

    Authors: Masayoshi Yasui, Masayuki Ohue, Shingo Noura, Norikatsu Miyoshi, Yusuke Takahashi, Chu Matsuda, Junichi Nishimura, Naotsugu Haraguchi, Hajime Ushigome, Nozomu Nakai, Shiki Fujino, Keijiro Sugimura, Hiroshi Wada, Hidenori Takahashi, Takeshi Omori and Hiroshi Miyata

    Citation: BMC Cancer 2021 21:911

    Content type: Research article

    Published on:

  40. Screening is defined as the identification of unrecognized disease in an apparently healthy population. Symptomatic individuals are recommended to contact a physician instead of participating in screening. How...

    Authors: Mette Bach Larsen, Heidi Heinsen Bachmann, Bo Søborg, Tinne Laurberg, Katrine J. Emmertsen, Søren Laurberg and Berit Andersen

    Citation: BMC Cancer 2021 21:910

    Content type: Research

    Published on:

  42. To compare the value of interim 18F-FLT-PET and 18F-FDG-PET for predicting treatment outcomes in patients with metastatic breast cancer after salvage therapy.

    Authors: Tzu-Pei Su, Jen-Seng Huang, Pei-Hung Chang, Kar-Wai Lui, Jason Chia-Hsun Hsieh, Shu-Hang Ng and Sheng-Chieh Chan

    Citation: BMC Cancer 2021 21:908

    Content type: Research

    Published on:

  43. A plethora of prognostic biomarkers for esophageal squamous cell carcinoma (ESCC) that have hitherto been reported are challenged with low reproducibility due to high molecular heterogeneity of ESCC. The purpo...

    Authors: Meng-Xiang Li, Xiao-Meng Sun, Wei-Gang Cheng, Hao-Jie Ruan, Ke Liu, Pan Chen, Hai-Jun Xu, She-Gan Gao, Xiao-Shan Feng and Yi-Jun Qi

    Citation: BMC Cancer 2021 21:906

    Content type: Research article

    Published on:

  44. The tumor microenvironment (TME) has significantly correlation with tumor occurrence and prognosis. Our study aimed to identify the prognostic immune-related genes (IRGs)in the tumor microenvironment of colore...

    Authors: Yuanyuan Wang, Wei Li, Xiaojing Jin, Xia Jiang, Shang Guo, Fei Xu, Xingkai Su, Guiqi Wang, Zengren Zhao and Xiaosong Gu

    Citation: BMC Cancer 2021 21:905

    Content type: Research

    Published on:

  45. In the phase 3 METEOR trial, cabozantinib improved progression-free survival (PFS) and overall survival (OS) versus everolimus in patients with advanced RCC after prior antiangiogenic therapy.

    Authors: Thomas Powles, Toni K. Choueiri, Robert J. Motzer, Eric Jonasch, Sumanta Pal, Nizar M. Tannir, Sabina Signoretti, Rajesh Kaldate, Christian Scheffold, Evelyn Wang, Dana T. Aftab, Bernard Escudier and Daniel J. George

    Citation: BMC Cancer 2021 21:904

    Content type: Research

    Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:1023

  46. 5-Fluorouracil (5-FU) is regarded as the first line treatment for colorectal cancer; however, its effectiveness is limited by drug resistance. The ultimate goal of cancer therapy is induction of cancer cell de...

    Authors: Hojatolla Nikravesh, Mohammad Javad Khodayar, Babak Behmanesh, Masoud Mahdavinia, Ali Teimoori, Soheila Alboghobeish and Leila Zeidooni

    Citation: BMC Cancer 2021 21:903

    Content type: Research

    Published on:

  47. Triple-negative mammary carcinoma (TNBC) is an aggressive breast cancer subtype associated with dismal prognosis. The interaction between the immune system and the cancer cells plays a crucial role in tumor de...

    Authors: Monique C. Tavares, Cristina D. Sampaio, Geraldine E. Lima, Victor P. Andrade, Daniel G. Gonçalves, Mariana P. Macedo and Vladmir C. Cordeiro de Lima

    Citation: BMC Cancer 2021 21:901

    Content type: Research

    Published on:

  48. This study aimed to assess the utility of deep learning analysis using pretreatment FDG-PET images to predict local treatment outcome in oropharyngeal squamous cell carcinoma (OPSCC) patients.

    Authors: Noriyuki Fujima, V. Carlota Andreu-Arasa, Sara K. Meibom, Gustavo A. Mercier, Minh Tam Truong, Kenji Hirata, Koichi Yasuda, Satoshi Kano, Akihiro Homma, Kohsuke Kudo and Osamu Sakai

    Citation: BMC Cancer 2021 21:900

    Content type: Research article

    Published on:

  49. Residual breast cancer after neo-adjuvant chemotherapy (NACT) predicts disease outcome and is a surrogate for survival in aggressive breast cancer (BC) subtypes. Pathological complete response (pCR) rate, howe...

    Authors: Alex De Caluwé, Laurence Buisseret, Philip Poortmans, Dirk Van Gestel, Roberto Salgado, Christos Sotiriou, Denis Larsimont, Marianne Paesmans, Ligia Craciun, Drisis Stylianos, Christophe Vandekerckhove, Fabien Reyal, Veys Isabelle, Daniel Eiger, Martine Piccart, Emanuela Romano…

    Citation: BMC Cancer 2021 21:899

    Content type: Study protocol

    Published on:

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