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  1. Enhancer of zeste homolog 2 (EZH2) is considered an important driver of tumor development and progression by its histone modifying capabilities. Inhibition of EZH2 activity is thought to be a potent treatment ...

    Authors: Chidimma Agatha Akpa, Karsten Kleo, Elisabeth Oker, Nancy Tomaszewski, Clemens Messerschmidt, Cristina López, Rabea Wagener, Kathrin Oehl-Huber, Katja Dettmer, Anne Schoeler, Dido Lenze, Peter J. Oefner, Dieter Beule, Reiner Siebert, David Capper, Lora Dimitrova…

    Citation: BMC Cancer 2020 20:427

    Content type: Research article

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  2. Colon cancer is one of the most commonly diagnosed types of cancer with surgical resection of the tumor being the primary choice of treatment. However, the surgical stress response induced during treatment may...

    Authors: Johanne Davidsen, Stine Bull Jessen, Sara Kehlet Watt, Sylvester Larsen, Katja Dahlgaard, Tove Kirkegaard, Ismail Gögenur and Jesper T. Troelsen

    Citation: BMC Cancer 2020 20:426

    Content type: Research article

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  3. Our aim was to investigate the value of serum squamous cell carcinoma (SCC) antigen levels in predicting chemosensitivity, lymph node metastasis, as well as prognosis in patients with cervical squamous cell ca...

    Authors: Peng Chen, Liang Jiao, Fang Ren and Dan-Bo Wang

    Citation: BMC Cancer 2020 20:423

    Content type: Research article

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  4. Chemotherapy with gemcitabine and cisplatin has been the standard of care in first-line chemotherapy for advanced biliary tract cancer (BTC) since the trial ABC-02 was published in 2010. We aimed to investigat...

    Authors: Chiao-En Wu, Wen-Chi Chou, Chia-Hsun Hsieh, John Wen-Cheng Chang, Cheng-Yu Lin, Chun-Nan Yeh and Jen-Shi Chen

    Citation: BMC Cancer 2020 20:422

    Content type: Research article

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  5. It is generally accepted that microRNA-20a (miR-20a) is aberrantly expressed in gastrointestinal cancer (GIC), and may be associated with the prognosis of GIC patients. Nevertheless, the clinical prognostic va...

    Authors: Qiliang Peng, Peifeng Zhao, Yi Shen, Ming Cheng, Yongyou Wu and Yaqun Zhu

    Citation: BMC Cancer 2020 20:420

    Content type: Research article

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  6. To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as t...

    Authors: Chen Qiu, Yuanyuan Bai, Tinghui Yin, Xiaoyan Miao, Rongkang Gao, Huichao Zhou, Jie Ren, Liang Song, Chengbo Liu, Hairong Zheng and Rongqin Zheng

    Citation: BMC Cancer 2020 20:419

    Content type: Research article

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  7. Elderly patients are underrepresented in clinical study where combined endocrine strategies were compared to endocrine therapy (ET) in hormone receptors positive, HER2 negative, metastatic breast cancer. The r...

    Authors: Claudia Omarini, Federico Piacentini, Isabella Sperduti, Monica Barbolini, Chrystel Isca, Angela Toss, Laura Cortesi, Elena Barbieri, Massimo Dominici and Luca Moscetti

    Citation: BMC Cancer 2020 20:418

    Content type: Research article

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  8. Pancreatic cancer remains a fatal disease. Experimental systems are needed for personalized treatment strategies, drug testing and to further understand tumor biology. Cell cultures can serve as an excellent p...

    Authors: L. Ehlen, J. Arndt, D. Treue, P. Bischoff, F. N. Loch, E. M. Hahn, K. Kotsch, F. Klauschen, K. Beyer, G. A. Margonis, M. E. Kreis and C. Kamphues

    Citation: BMC Cancer 2020 20:417

    Content type: Research article

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  9. KRAS mutations have been characterized as the major predictive biomarkers for resistance to cetuximab treatment. However, studies indicate that not all KRAS mutations are associated with equivalent treatment o...

    Authors: Hangyu Zhang, Liyun Yuan, Lulu Liu, Cong Yan, Jinming Cheng, Qihan Fu, Zhou Tong, Weiqin Jiang, Yi Zheng, Peng Zhao, Guoqing Zhang and Weijia Fang

    Citation: BMC Cancer 2020 20:416

    Content type: Research article

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  10. Curative treatment for upper gastrointestinal (UGI) and hepatopancreaticobiliary (HPB) cancers, involves complex surgical resection often in combination with neoadjuvant/adjuvant chemo/chemoradiotherapy. With ...

    Authors: Linda O’Neill, Emer Guinan, Suzanne Doyle, Deirdre Connolly, Jacintha O’Sullivan, Annemarie Bennett, Grainne Sheill, Ricardo Segurado, Peter Knapp, Ciaran Fairman, Charles Normand, Justin Geoghegan, Kevin Conlon, John V. Reynolds and Juliette Hussey

    Citation: BMC Cancer 2020 20:415

    Content type: Study protocol

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  11. Anaemia is highly prevalent in gastric cancer (GC) patients. The role of initial haemoglobin levels in predicting the prognosis of GC patients treated by chemotherapy has not been well determined. Our present ...

    Authors: Wen-Huan Li, Ji-Yu Zhang, Wen-Hui Liu and Xian-Xian Chen

    Citation: BMC Cancer 2020 20:414

    Content type: Research article

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  12. A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underly...

    Authors: Jihoon Choi, Danai G. Topouza, Anastasiya Tarnouskaya, Sean Nesdoly, Madhuri Koti and Qing Ling Duan

    Citation: BMC Cancer 2020 20:413

    Content type: Research article

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  14. Anti-tumor effects of radiation therapy (RT) largely depend on host immune function. Adenosine with its strong immunosuppressive properties is an important immune checkpoint molecule.

    Authors: Hidenori Tsukui, Hisanaga Horie, Koji Koinuma, Hideyuki Ohzawa, Yasunaru Sakuma, Yoshinori Hosoya, Hironori Yamaguchi, Kotaro Yoshimura, Alan Kawarai Lefor, Naohiro Sata and Joji Kitayama

    Citation: BMC Cancer 2020 20:411

    Content type: Research article

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  15. Neurosurgical resection represents an important treatment option in the modern, multimodal therapy approach of brain metastases (BM). Guidelines for perioperative imaging exist for primary brain tumors to guid...

    Authors: Barbara Kiesel, Carina M. Thomé, Tobias Weiss, Asgeir S. Jakola, Amélie Darlix, Alessia Pellerino, Julia Furtner, Johannes Kerschbaumer, Christian F. Freyschlag, Wolfgang Wick, Matthias Preusser, Georg Widhalm and Anna S. Berghoff

    Citation: BMC Cancer 2020 20:410

    Content type: Research article

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  16. Single nucleotide polymorphisms (SNPs) in DNA repair genes have a potential clinical value in predicting treatment outcomes. In the current study, we examined the association of SNPs in the genes XRCC1-rs25487...

    Authors: Hamideh Salimzadeh, Elinor Bexe Lindskog, Bengt Gustavsson, Yvonne Wettergren and David Ljungman

    Citation: BMC Cancer 2020 20:409

    Content type: Research article

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  17. Over the past years, EGFR tyrosine kinase inhibitors (TKI) revolutionized treatment response. 1st-generation (reversible) EGFR TKI and later the 2nd –generation irreversible EGFR TKI Afatinib were aimed to imp...

    Authors: Svenja Wagener-Ryczek, Carina Heydt, Juliane Süptitz, Sebastian Michels, Markus Falk, Christina Alidousty, Jana Fassunke, Michaela Angelika Ihle, Markus Tiemann, Lukas Heukamp, Jürgen Wolf, Reinhard Büttner and Sabine Merkelbach-Bruse

    Citation: BMC Cancer 2020 20:408

    Content type: Research article

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  18. Thyroid Hurthle cell carcinoma (HCC) is a rare disease with high risk of invasion and metastasis and poor prognosis. The clinical characteristics, prognosis and treatment of HCC are still controversial, and cl...

    Authors: Xingtong Zhou, Zhibo Zheng, Chuyan Chen, Bangbo Zhao, Hongtao Cao, Tianhao Li, Xudong Liu, Weibin Wang and Yongning Li

    Citation: BMC Cancer 2020 20:407

    Content type: Research article

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  19. Pelvic nodal recurrences are being increasingly diagnosed with the introduction of new molecular imaging techniques, like choline and PSMA PET-CT, in the restaging of recurrent prostate cancer (PCa). At this m...

    Authors: A. De Bruycker, A. Spiessens, P. Dirix, N. Koutsouvelis, I. Semac, N. Liefhooghe, A. Gomez-Iturriaga, W. Everaerts, F. Otte, A. Papachristofilou, M. Scorsetti, M. Shelan, S. Siva, F. Ameye, M. Guckenberger, R. Heikkilä…

    Citation: BMC Cancer 2020 20:406

    Content type: Study protocol

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  20. The prognosis of patients with perihilar cholangiocarcinoma have been unsatisfactory. We established new anatomical resectability classification for patients with localized perihilar cholangiocarcinoma and per...

    Authors: Naohisa Kuriyama, Masanobu Usui, Kazuaki Gyoten, Aoi Hayasaki, Takehiro Fujii, Yusuke Iizawa, Hiroyuki Kato, Yasuhiro Murata, Akihiro Tanemura, Masashi Kishiwada, Hiroyuki Sakurai, Shugo Mizuno and Shuji Isaji

    Citation: BMC Cancer 2020 20:405

    Content type: Research article

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  21. Patients with oligometastatic disease can potentially be cured by using an ablative therapy for all active lesions. Stereotactic body radiotherapy (SBRT) is a non-invasive treatment option that lately proved t...

    Authors: Goda G. Kalinauskaite, Ingeborg I. Tinhofer, Markus M. Kufeld, Anne A. Kluge, Arne A. Grün, Volker V. Budach, Carolin C. Senger and Carmen C. Stromberger

    Citation: BMC Cancer 2020 20:404

    Content type: Research article

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  22. Recent genome-wide association studies (GWASs) have suggested several susceptibility loci of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) by statistical analysis at individual single-nucleoti...

    Authors: Deke Jiang, Jiaen Deng, Changzheng Dong, Xiaopin Ma, Qianyi Xiao, Bin Zhou, Chou Yang, Lin Wei, Carly Conran, S. Lilly Zheng, Irene Oi-lin Ng, Long Yu, Jianfeng Xu, Pak C. Sham, Xiaolong Qi, Jinlin Hou…

    Citation: BMC Cancer 2020 20:403

    Content type: Research article

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  23. Our aim is to report treatment efficacy and toxicity of patients treated by robotic (Cyberknife®) stereotactic body radiotherapy (SBRT) for oligorecurrent lung metastases (ORLM). Additionally we wanted to eval...

    Authors: Patrick Berkovic, Akos Gulyban, Gilles Defraene, Laurie Swenen, David Dechambre, Paul Viet Nguyen, Nicolas Jansen, Carole Mievis, Pierre Lovinfosse, Levente Janvary, Maarten Lambrecht and Gert De Meerleer

    Citation: BMC Cancer 2020 20:402

    Content type: Research article

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  24. Research and cancer care are closely intertwined; however, it is not clear whether physicians and nurses believe that clinical trials offer the best treatment for patients and, if so, whether this belief is ju...

    Authors: Zandra Engelbak Nielsen, Stefan Eriksson, Laurine Bente Schram Harsløf, Suzanne Petri, Gert Helgesson, Margrete Mangset and Tove E. Godskesen

    Citation: BMC Cancer 2020 20:401

    Content type: Research article

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  25. Mucinous adenocarcinoma (MAC) is a distinct type of colorectal cancer (CRC) associated with poor response to treatment and poorer prognosis. MAC is diagnosed by WHO definition when the extracellular mucin is m...

    Authors: Xiaodong Li, Katherine Sun, Xiaoyan Liao, Haijuan Gao, Hongfa Zhu and Ruliang Xu

    Citation: BMC Cancer 2020 20:400

    Content type: Research article

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  26. Head and Neck cancer (HNC) is characterized by significant mortality and morbidity. Treatment is often invasive and interferes with vital functions, resulting in a delicate balance between survival benefit and...

    Authors: Arta Hoesseini, Emilie A. C. Dronkers, Aniel Sewnaik, Jose A. U. Hardillo, Robert J. Baatenburg de Jong and Marinella P. J. Offerman

    Citation: BMC Cancer 2020 20:399

    Content type: Research article

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  27. Metastatic prostate cancer (PC) is highly lethal. The ability to identify primary tumors capable of dissemination is an unmet need in the quest to understand lethal biology and improve patient outcomes. Previo...

    Authors: Eric T. Miller, Sungyong You, Radu M. Cadaneanu, Minhyung Kim, Junhee Yoon, Sandy T. Liu, Xinmin Li, Lorna Kwan, Jennelle Hodge, Michael J. Quist, Catherine S. Grasso, Michael S. Lewis, Beatrice S. Knudsen, Michael R. Freeman and Isla P. Garraway

    Citation: BMC Cancer 2020 20:398

    Content type: Research article

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  28. Chronic myeloid leukaemia is in principle a treatable malignancy but drug resistance is lowering survival. Recent drug discoveries have opened up new options for drug combinations, which is a concept used in o...

    Authors: H. Jonathan G. Lindström and Ran Friedman

    Citation: BMC Cancer 2020 20:397

    Content type: Research Article

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  29. To ensure the highest quality of human papillomavirus (HPV) testing in primary cervical cancer screening, novel HPV assays must be evaluated in accordance with the international guidelines. Furthermore, HPV as...

    Authors: Ditte Møller Ejegod, Camilla Lagheden, Ramya Bhatia, Helle Pedersen, Elia Alcañiz Boada, Karin Sundström, Javier Cortés, F. Xavier Bosch Josë, Kate Cuschieri, Joakim Dillner and Jesper Bonde

    Citation: BMC Cancer 2020 20:396

    Content type: Research article

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  31. Spatial heterogeneity of prostate cancer-specific mortality in Pennsylvania remains unclear. We utilized advanced geospatial survival regressions to examine spatial variation of prostate cancer-specific mortal...

    Authors: Ming Wang, Emily Wasserman, Nathaniel Geyer, Rachel M. Carroll, Shanshan Zhao, Lijun Zhang, Raymond Hohl, Eugene J. Lengerich and Alicia C. McDonald

    Citation: BMC Cancer 2020 20:394

    Content type: Research article

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  32. Induction chemotherapy (IC) combined with concurrent chemoradiotherapy (CCRT) has been recommended as the first-line therapy for locoregional nasopharyngeal carcinoma (NPC). Due to the different chemotherapeut...

    Authors: Bi-Cheng Wang, Bo-Ya Xiao, Guo-He Lin, Chang Wang and Quentin Liu

    Citation: BMC Cancer 2020 20:393

    Content type: Research article

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  33. The ABCSG-28 trial compared primary surgery followed by systemic therapy versus primary systemic therapy without surgery in patients with de novo stage IV BC. The present report describes QoL results of this t...

    Authors: V. Bjelic-Radisic, F. Fitzal, M. Knauer, G. Steger, D. Egle, R. Greil, P. Schrenk, M. Balic, Ch. Singer, R. Exner, L. Soelkner and Michael Gnant

    Citation: BMC Cancer 2020 20:392

    Content type: Research article

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  34. Pathogenic variants that occur in the familial breast cancer genes (BRCA1/2) lead to truncated ineffective proteins in the majority of cases. These variants are mostly represented by small deletions/insertions, n...

    Authors: Nerina C. van der Merwe, Jaco Oosthuizen, Magdalena Theron, George Chong and William D. Foulkes

    Citation: BMC Cancer 2020 20:391

    Content type: Research article

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  35. Osteosarcoma (OS) is the most frequent primary malignancy of bone with a high incidence in adolescence. This study aimed to construct a publicly available, integrated database of human OS, named HOsDb.

    Authors: Yifu Sun, Lishan Wang, Changkuan Li, Rui Gu, Weidong Zang, Wei Song and Peng Xia

    Citation: BMC Cancer 2020 20:390

    Content type: Database

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  36. To assess metastatic breast cancer (MBC) patient psychological factors, perceptions, and comprehension of tumor genomic testing.

    Authors: Elizabeth J. Adams, Sarah Asad, Raquel Reinbolt, Katharine A. Collier, Mahmoud Abdel-Rasoul, Susan Gillespie, James L. Chen, Mathew A. Cherian, Anne M. Noonan, Sagar Sardesai, Jeffrey VanDeusen, Robert Wesolowski, Nicole Williams, Charles L. Shapiro, Erin R. Macrae, Robert Pilarski…

    Citation: BMC Cancer 2020 20:389

    Content type: Research article

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  37. Esophageal squamous cell carcinoma (ESCC) is a leading cause of cancer death worldwide and in China. We know miRNAs influence gene expression in tumorigenesis, but it is unclear how miRNAs affect gene expressi...

    Authors: Howard Yang, Hua Su, Nan Hu, Chaoyu Wang, Lemin Wang, Carol Giffen, Alisa M. Goldstein, Maxwell P. Lee and Philip R. Taylor

    Citation: BMC Cancer 2020 20:388

    Content type: Research article

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  39. According to GLOBOSCAN, hepatocellular carcinoma (HCC) claimed 782,000 lives in 2018. The tyrosine kinase inhibitor sofafenib is used to treat HCC, but new anticancer agents targeting different pathways are ur...

    Authors: Ruey-Shyang Soong, Ravi K. Anchoori, Richard B. S. Roden, Rou-Ling Cho, Yi-Chan Chen, Sheng-Chieh Tseng, Yun-Li Huang, Po-Cheng Liao and Yu-Chiau Shyu

    Citation: BMC Cancer 2020 20:386

    Content type: Research article

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  40. Primary debulking surgery (PDS) and adjuvant chemotherapy is the standard treatment for advanced ovarian, fallopian or primary peritoneal cancer. However, neoadjuvant chemotherapy (NAC) followed by interval de...

    Authors: Soo Jin Park, Seung-Hyuk Shim, Yong-Il Ji, Sang-Hoon Kwon, Eun Ji Lee, Maria Lee, Suk Joon Chang, Samina Park, Sang Youn Kim, Sung Jong Lee, Jae-Weon Kim, Ju-Won Roh, San Hui Lee, Taejong Song and Hee Seung Kim

    Citation: BMC Cancer 2020 20:385

    Content type: Study protocol

    Published on:

  41. The comprehensive geriatric assessment (CGA) is the gold standard in geriatric oncology to identify patients at high risk of adverse outcomes and optimize cancer and overall management. Many studies have demon...

    Authors: Sandrine Sourdet, Delphine Brechemier, Zara Steinmeyer, Stephane Gerard and Laurent Balardy

    Citation: BMC Cancer 2020 20:384

    Content type: Research article

    Published on:

  42. The microbiome has been shown to affect the response to Immune Checkpoint Inhibitors (ICIs) in a small number of cancers and in preclinical models. Here, we sought to broadly survey cancers to identify those i...

    Authors: Daniel Spakowicz, Rebecca Hoyd, Mitchell Muniak, Marium Husain, James S. Bassett, Lei Wang, Gabriel Tinoco, Sandip H. Patel, Jarred Burkart, Abdul Miah, Mingjia Li, Andrew Johns, Madison Grogan, David P. Carbone, Claire F. Verschraegen, Kari L. Kendra…

    Citation: BMC Cancer 2020 20:383

    Content type: Research article

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  43. Chronic inflammation is considered as a hallmark of gastric cancer (GC) and plays a critical role in GC progression and metastasis. This study aimed to explore the prognostic values of preoperative fibrinogen-...

    Authors: Shuli Tang, Lin Lin, Jianan Cheng, Juan Zhao, Qijia Xuan, Jiayue Shao, Yang Zhou and Yanqiao Zhang

    Citation: BMC Cancer 2020 20:382

    Content type: Research article

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  44. The purpose of this study was to assess the efficacy and safety of cisplatin-based chemotherapy with or without bevacizumab (BEV) in Chinese women with advanced cervical cancer (ACC).

    Authors: Xiaoli He, Jun Liu, Li Xiao, Mingdong Zhao, Tingting Su, Tiejian Liu, Guowei Han and Yue Wang

    Citation: BMC Cancer 2020 20:381

    Content type: Research article

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  45. A recent randomized phase II trial evaluated stereotactic ablative radiotherapy (SABR) in a group of patients with a small burden of oligometastatic disease (mostly with 1–3 metastatic lesions), and found that...

    Authors: Robert Olson, Lindsay Mathews, Mitchell Liu, Devin Schellenberg, Benjamin Mou, Tanya Berrang, Stephen Harrow, Rohann J. M. Correa, Vasudeva Bhat, Howard Pai, Islam Mohamed, Stacy Miller, Famke Schneiders, Joanna Laba, Derek Wilke, Sashendra Senthi…

    Citation: BMC Cancer 2020 20:380

    Content type: Study protocol

    Published on:

  46. In randomized controlled trials (RCTs) of adjuvant treatment for malignant tumors, event-free survival (EFS) is considered the most acceptable surrogate for overall survival (OS). However, even though EFS has ...

    Authors: Kazuhiro Tanaka, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga and Hiroshi Tsumura

    Citation: BMC Cancer 2020 20:379

    Content type: Research article

    Published on:

  47. Skin cutaneous melanoma (SKCM) is one of most aggressive type of cancers worldwide. Serglycin (SRGN) is an intracellular proteoglycan that playing an important role in various tumors. However, its effect on im...

    Authors: Xiaofang Wang, Hui Xiong, Daning Liang, Zhenzhen Chen, Xiqing Li and Kun Zhang

    Citation: BMC Cancer 2020 20:378

    Content type: Research article

    Published on:

  48. Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER−), cytokeratin 5/6 positivity and basal-like features of breast c...

    Authors: Nina Gran Egeland, Kristin Jonsdottir, Miriam Ragle Aure, Kristine Sahlberg, Vessela N. Kristensen, Deirdre Cronin-Fenton, Ivar Skaland, Einar Gudlaugsson, Jan P. A. Baak and Emiel A. M. Janssen

    Citation: BMC Cancer 2020 20:377

    Content type: Research article

    Published on:

  50. The adhesion molecule, FAT4, has a tumor suppressor function with a critical role in the epithelial-to-mesenchymal-transition (EMT) and anti-malignant growth in several cancers. No study has investigated yet i...

    Authors: Shika Hanif Malgundkar, Ikram Burney, Mansour Al Moundhri, Moza Al Kalbani, Ritu Lakhtakia, Aikou Okamoto and Yahya Tamimi

    Citation: BMC Cancer 2020 20:374

    Content type: Research article

    Published on:

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