Skip to main content

Articles

Page 5 of 278

  1. Invadopodia, actin-rich structures that release metallo-proteases at the interface with extra-cellular matrix, in a punctate manner are thought to be important drivers of tumour invasion. Invadopodia formation...

    Authors: Valeria Manuelli, Fidelma Cahill, Harriet Wylie, Cheryl Gillett, Isabel Correa, Susanne Heck, Alex Rimmer, Anna Haire, Mieke Van Hemelrijck, Sarah Rudman and Claire M. Wells
    Citation: BMC Cancer 2022 22:386
  2. Little is known about whether age at initial diagnosis influences the prognosis of recurrent metastatic breast cancer (rMBC). Here, we analyzed the association between age at initial diagnosis and rMBC mortali...

    Authors: Yuxin Xie, Qiheng Gou, Yingjie Zhang, Keqi Xie, Dan Zheng, Chuanxu Luo, Jiaojiao Suo, Xiaorong Zhong and Ting Luo
    Citation: BMC Cancer 2022 22:385
  3. A retrospective study and a randomized controlled trial published in a high quality journal in late 2018 have shown that laparoscopic radical hysterectomy (RH) was associated with worse survival than abdominal...

    Authors: Xin Wu, Hao Feng, Shujun Gao, Hua Feng, Wenjing Diao, Hongwei Zhang, Ming Du, Weihua Lou, Xipeng Wang, Tao Zhu, Yuyang Zhang, Weiguo Hu, Xiaohong Xue, Zhiling Zhu, Libing Xiang, Jiarui Li…
    Citation: BMC Cancer 2022 22:384
  4. Patients with cancer often endure substantial symptoms and treatment toxicities leading to high healthcare utilization, including hospitalizations and emergency department visits, throughout the continuum of t...

    Authors: Ryan D. Nipp, Eliza Shulman, Melissa Smith, Patricia M. C. Brown, P. Connor Johnson, Eva Gaufberg, Charu Vyas, Carolyn L. Qian, Isabel Neckermann, Shira B. Hornstein, Mathew J. Reynolds, Joseph Greer, Jennifer S. Temel and Areej El-Jawahri
    Citation: BMC Cancer 2022 22:383
  5. The accuracy of CT and tumour markers in screening lung cancer needs to be improved. Computer-aided diagnosis has been reported to effectively improve the diagnostic accuracy of imaging data, and recent studie...

    Authors: Han Yang, Hongjie Chen, Guorui Zhang, Hongyi Li, Ran Ni, Yali Yu, Yepeng Zhang, Yongjun Wu and Hong Liu
    Citation: BMC Cancer 2022 22:382
  6. Tivozanib (Fotivda) is an anti-angiogenic tyrosine kinase inhibitor that was denied access to the US market by the Food and Drug Administration (FDA). In contrast, it was granted approval by the European Medic...

    Authors: Laura Caquelin, Mohamed Gewily, Wendy Mottais, Chloé Tebaldi, Bruno Laviolle, Florian Naudet and Clara Locher
    Citation: BMC Cancer 2022 22:381
  7. Hepatocellular carcinoma (HCC) is the third-most deadly cancer worldwide. More breakthroughs are needed in the clinical practice for liver cancer are needed, and new treatment strategies are required. This stu...

    Authors: Chenkai Huang, Juanjuan Zhou, Yuan Nie, Guihai Guo, Anjiang Wang and Xuan Zhu
    Citation: BMC Cancer 2022 22:380
  8. The combined application of immune cells and specific biomarkers related to the tumor immune microenvironment has a better predictive value for the prognosis of HCC. The purpose of this study is to construct a...

    Authors: Youpeng Wang, Yeni Yang, Ziyin Zhao, Hongfa Sun, Dingan Luo, Lakshmi Huttad, Bingyuan Zhang and Bing Han
    Citation: BMC Cancer 2022 22:379
  9. The phase 3 ATTRACTION-2 study demonstrated that nivolumab monotherapy improved survival compared to placebo in patients with pretreated advanced gastric cancer (AGC). However, the efficacy of nivolumab seems ...

    Authors: Jwa Hoon Kim, Min-Hee Ryu, Young Soo Park, Jungeun Ma, Sun Young Lee, Deokhoon Kim and Yoon-Koo Kang
    Citation: BMC Cancer 2022 22:378
  10. Patients with hepatocellular carcinoma (HCC) and Child–Pugh B liver cirrhosis have poor prognosis and are underrepresented in clinical trials. The CELESTIAL trial, in which cabozantinib improved overall surviv...

    Authors: Anthony B. El-Khoueiry, Tim Meyer, Ann-Lii Cheng, Lorenza Rimassa, Suvajit Sen, Steven Milwee, Robin Kate Kelley and Ghassan K. Abou-Alfa
    Citation: BMC Cancer 2022 22:377
  11. Ovarian cancer (OC) is the fifth most common malignant female cancer with a high mortality, mainly because of aggressive high-grade serous carcinomas (HGSOC), but also due to absence of specific early symptoms...

    Authors: Fabio Walther, Jana Ladina Berther, Alexandros Lalos, Michaela Ramser, Simone Eichelberger, Robert Mechera, Savas Soysal, Simone Muenst, Alberto Posabella, Uwe Güth, Sylvia Stadlmann, Luigi Terracciano, Raoul A. Droeser, Jasmin Zeindler and Gad Singer
    Citation: BMC Cancer 2022 22:376
  12. In patients with bone metastatic castration-resistant prostate cancer (bmCRPC) on systemic treatment, it is difficult to differentiate between continuous rise of prostate specific antigen (PSA) representing pr...

    Authors: Renata Poteska, Kambiz Rahbar, Axel Semjonow, Andres Jan Schrader, Martin Boegemann and Katrin Schlack
    Citation: BMC Cancer 2022 22:375
  13. Studies investigating breast cancer polygenic risk score (PRS) in Chinese women are scarce. The objectives of this study were to develop and validate PRSs that could be used to stratify risk for overall and su...

    Authors: Can Hou, Bin Xu, Yu Hao, Daowen Yang, Huan Song and Jiayuan Li
    Citation: BMC Cancer 2022 22:374
  14. The risk of recurrence after resection of a stage II or III colon cancer, and therefore qualification for adjuvant chemotherapy (ACT), is traditionally based on clinicopathological parameters. However, the par...

    Authors: Sjoerd H. Uil, Veerle M. H. Coupé, Herman Bril, Gerrit A. Meijer, Remond J. A. Fijneman and Hein B. A. C. Stockmann
    Citation: BMC Cancer 2022 22:372
  15. Toxicity during chemoradiotherapy (CRT) in cervical cancer patients might limit the chances of receiving an optimal treatment and to be cured. Few studies have shown relationships between acute side effects an...

    Authors: Annica Holmqvist, Gabriel Lindahl, Rasmus Mikivier and Srinivas Uppungunduri
    Citation: BMC Cancer 2022 22:371
  16. T-cell immunoglobulin mucin-1 (TIM-1) has been reported to be associated with the biological behavior of several malignant tumors; however, it is not clear whether it has a role in cervical cancer (CC).

    Authors: Liuyan Chen, Jilin Qing, Yangyang Xiao, Xiaomei Huang, Yanlin Chi and Zhizhong Chen
    Citation: BMC Cancer 2022 22:370
  17. The utility of circulating tumour DNA (ctDNA) for longitudinal tumour monitoring in pancreatic ductal adenocarcinoma (PDAC) has not been explored beyond mutations in the KRAS proto-oncogene. Here, we aimed to cha...

    Authors: Lavanya Sivapalan, Graeme J. Thorn, Emanuela Gadaleta, Hemant M. Kocher, Helen Ross-Adams and Claude Chelala
    Citation: BMC Cancer 2022 22:369
  18. This study aimed to evaluate the utility of inflammation-based prognostic scores (IBPS) and systemic immune-inflammation index (SII) in the treatment of oral cancer patients.

    Authors: Kosei Kubota, Ryohei Ito, Norihiko Narita, Yusuke Tanaka, Ken Furudate, Natsumi Akiyama, Chuang Hao Chih, Shotaro Komatsu and Wataru Kobayashi
    Citation: BMC Cancer 2022 22:368
  19. High-grade and recurrent meningiomas are often treatment resistant and pose a therapeutic challenge after surgical and radiation therapy (RT) failure. Temozolomide (TMZ) is a DNA alkylating agent that appears ...

    Authors: Katherine Belanger, Timothy H. Ung, Denise Damek, Kevin O. Lillehei and D. Ryan Ormond
    Citation: BMC Cancer 2022 22:367
  20. N6-methyladenosine (m6A) mRNA modification triggers malignant behaviors of tumor cells and thereby drives malignant progression in gastric cancer (GC). However, data regarding the prognostic values of m6A RNA met...

    Authors: Liangliang Lei, Nannan Li, Pengfei Yuan and Dechun Liu
    Citation: BMC Cancer 2022 22:365
  21. In clinical practice, the effect of durvalumab and radiation pneumonitis (RP) on survival after intensity-modulated radiotherapy (IMRT) is not fully understood. The purpose of this retrospective study was to i...

    Authors: Takaya Yamamoto, Yoko Tsukita, Yu Katagiri, Haruo Matsushita, Rei Umezawa, Yojiro Ishikawa, Noriyoshi Takahashi, Yu Suzuki, Kazuya Takeda, Eisaku Miyauchi, Ryota Saito, Yoshiyuki Katsuta, Noriyuki Kadoya and Keiichi Jingu
    Citation: BMC Cancer 2022 22:364
  22. Radio-chemotherapy with 5-flu orouracil (5-FU) is the standard of care treatment for patients with colorectal cancer, but it is only effective for a third of them. Despite our understanding of the mechanism of...

    Authors: Anaïs Chauvin, Danny Bergeron, Jean Vencic, Dominique Lévesque, Benoit Paquette, Michelle S. Scott and François-Michel Boisvert
    Citation: BMC Cancer 2022 22:363
  23. Tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) may be useful prognostic indicators in endometrial cancer. However, standardized assessment methods and the prognostic roles of the...

    Authors: Takako Kono-Sato, Kosuke Miyai, Yoji Yamagishi, Morikazu Miyamoto, Masashi Takano, Susumu Matsukuma, Kimiya Sato and Hitoshi Tsuda
    Citation: BMC Cancer 2022 22:361
  24. Women with metastatic breast cancer (MBC) report debilitating physical and psychological symptoms, including fatigue, anxiety, and pain, that greatly impact their quality of life. Immersive virtual reality (VR...

    Authors: Lisa M. Reynolds, Alana Cavadino, Stanley Chin, Zoë Little, Amelia Akroyd, Geraldine Tennant, Rosie Dobson, Reuben Broom and Adèle Gautier
    Citation: BMC Cancer 2022 22:360
  25. Additive/adjuvant chemotherapy as concept after local treatment of colorectal metastases has not been proven to be successful by phase III trials. Accordingly, a standard of care to improve relapse rates and l...

    Authors: Nathanael Raschzok, Sebastian Stintzing, Volker Heinemann, Geraldine Rauch, Jens Ricke, Matthias Guckenberger, Annika Kurreck, Annabel H. S. Alig, Arndt Stahler, Lars Bullinger, Moritz Schmelzle, Wenzel Schöning, Georg Lurje, Felix Krenzien, Oliver Haase, Beate Rau…
    Citation: BMC Cancer 2022 22:359
  26. Breast-conserving surgery (BCS) and whole breast radiation therapy (WBRT) are the standard of care for early-stage breast cancer (BC). Based on the observation that most local recurrences occurred near the tum...

    Authors: Maria Alessia Zerella, Mattia Zaffaroni, Giuseppe Ronci, Samantha Dicuonzo, Damaris Patricia Rojas, Anna Morra, Cristiana Fodor, Elena Rondi, Sabrina Vigorito, Francesca Botta, Marta Cremonesi, Cristina Garibaldi, Silvia Penco, Viviana Enrica Galimberti, Mattia Intra, Sara Gandini…
    Citation: BMC Cancer 2022 22:358
  27. Lymph node (LN) status is a key prognostic factor in the decision-making process of different cancer entities, including prostate cancer (PCa). Sectioning and haematoxylin and eosin (H&E) staining technique re...

    Authors: Mercè Cuadras, Jacques Planas, Ana Celma, Lucas Regis, Inés M. de Torres, M. Eugenia Semidey, Enrique Trilla and Juan Morote
    Citation: BMC Cancer 2022 22:357
  28. Colorectal cancer (CRC) incidence in Finland has risen steadily. Given development in cancer treatments in recent decades, disease-specific data on the long-term prognosis of patients may be obsolete. Thus, th...

    Authors: Tobias Olenius, Laura Koskenvuo, Selja Koskensalo, Anna Lepistö and Camilla Böckelman
    Citation: BMC Cancer 2022 22:356
  29. We aimed to investigate response and prognostic factors in patients with human epidermal growth factor receptor 2 (HER2) positive metastatic colorectal cancer (mCRC) and compare the curative effect on patients...

    Authors: Liu Yang, Wenfei Li, Zhihao Lu, Ming Lu, Jun Zhou, Zhi Peng, Xiaotian Zhang, Xicheng Wang, Lin Shen and Jian Li
    Citation: BMC Cancer 2022 22:355
  30. Papillary thyroid carcinoma (PTC) is the most common histological type of thyroid malignancy that tends to metastasize to cervical lymph nodes. In the present study, we aimed to investigate which clinicopathol...

    Authors: Cui Zhang, Baojun Li, Lei Zhang, Fengjiao Chen, Yanhua Zhang and Wen Cheng
    Citation: BMC Cancer 2022 22:354
  31. Depression has been reported to be associated with some types of cancer in observational studies. However, the direction and magnitude of the causal relationships between depression and different types of canc...

    Authors: Guang-Li Zhu, Cheng Xu, Kai-bin Yang, Si-Qi Tang, Ling-Long Tang, Lei Chen, Wen-Fei Li, Yan-Ping Mao and Jun Ma
    Citation: BMC Cancer 2022 22:353
  32. Recently the role of microRNAs has been explored immensely as novel regulators and potential biomarkers in several cancers. MiR-509-3p is one such miRNA that has been observed to show a mixed expression in dif...

    Authors: Deepak Narayanan Iyer, Dominic Chi-Chung Foo, Oswens Siu-Hung Lo, Timothy Ming-Hun Wan, Xue Li, Ryan Wai-Yan Sin, Roberta Wen-Chi Pang, Wai-Lun Law and Lui Ng
    Citation: BMC Cancer 2022 22:351
  33. The purpose of this study was to investigate the ability of differential diagnosis of prostate specific antigen decline rate (PSADR) per week, degree of prostatic collapse (DPC) and tissue signal rate of prost...

    Authors: Minxin He, Li Wang, Hong Wang, Fang Liu, Mingrui Li, Tie Chong and Li Xue
    Citation: BMC Cancer 2022 22:348
  34. In women with newly diagnosed ovarian cancer, bevacizumab and poly (ADP-ribose) polymerase inhibitors (PARPi) exhibit improved progression-free survival (PFS) when administered concurrent with chemotherapy and...

    Authors: Young Ju Suh, Banghyun Lee, Kidong Kim, Yujin Jeong, Hwa Yeon Choi, Sung Ook Hwang and Yong Beom Kim
    Citation: BMC Cancer 2022 22:346
  35. Although cigarette smoking is the most significant risk factor for laryngeal cancer, other risk factors might also be associated with the development of laryngeal cancer. We investigated whether underweight an...

    Authors: Oh. Hyeong Lee, Yong-Moon Park, Seung-Hyun Ko, Kyuna Lee, Yeonji Kim, Kyungdo Han and Jung-Hae Cho
    Citation: BMC Cancer 2022 22:345
  36. The incidence and mortality of thyroid cancer (TC) has been steadily rising in the past decades. It is imperative to have a better understanding of the molecular mechanisms underlying TC development and identi...

    Authors: Xiaozhou Zhang, Xiaojian Zhang, Qian Jia, Hongqiang Li, Runsheng Ma, Guang Yang, Fengyan Yin, Nannan Jiang and Detao Yin
    Citation: BMC Cancer 2022 22:344
  37. The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is...

    Authors: Jan Bieńkiewicz, Hanna Romanowicz, Bożena Szymańska, Daria Domańska-Senderowska, Miłosz Wilczyński, Anna Stepowicz, Andrzej Malinowski and Beata Smolarz
    Citation: BMC Cancer 2022 22:343
  38. Platinum-based chemoradiotherapy is the standard treatment for unresectable stage III non-small-cell lung cancer (NSCLC). However, few studies have evaluated the efficacy of subsequent chemotherapy for relapse...

    Authors: Eriko Miyawaki, Hirotsugu Kenmotsu, Yasushi Shintani, Ikuo Sekine, Takehito Shukuya, Koichi Takayama, Akira Inoue, Isamu Okamoto, Katsuyuki Kiura, Kazuhisa Takahashi, Nobuyuki Yamamoto, Tomoya Kawaguchi, Etsuo Miyaoka, Ichiro Yoshino and Hiroshi Date
    Citation: BMC Cancer 2022 22:342
  39. Since colon cancer stem cells (CSCs) play an important role in chemoresistance and in tumor recurrence and metastasis, targeting of CSCs has emerged as a sophisticated strategy for cancer therapy. α-mangostin ...

    Authors: Min Kyoung Jo, Chang Mo Moon, Eun Ju Kim, Ji-Hee Kwon, Xiang Fei, Seong-Eun Kim, Sung-Ae Jung, Minsuk Kim, Yeung-Chul Mun, Young-Ho Ahn, Seung-Yong Seo and Tae Il Kim
    Citation: BMC Cancer 2022 22:341
  40. Childhood cancer survivors lacking awareness on their potential risks of late effects often fail to seek adequate follow-up care. Patient education matching their preference is of great importance to improve t...

    Authors: Daisuke Masumoto, Etsuko Nakagami-Yamaguchi, Misako Nambu, Miho Maeda, Hideko Uryu, Akira Hayakawa, Zayar Linn, Satoshi Okamura, Kosuke Kurihara, Kentaro Kihira, Takao Deguchi and Hiroki Hori
    Citation: BMC Cancer 2022 22:340
  41. An accurate knowledge of the relocation of prostate neoplasms during biopsy is of great importance to reduce the number of false negative results. Prostate neoplasms are visible in magnetic resonance images (M...

    Authors: Muhammad Qasim, Dolors Puigjaner, Joan Herrero, Josep M. López, Carme Olivé, Gerard Fortuny and Josep Garcia-Bennett
    Citation: BMC Cancer 2022 22:338
  42. Failure rate in randomized controlled trials (RCTs) is > 50%, includes safety-problems, underpowered statistics, lack of efficacy, lack of funding or insufficient patient recruitment and is even more pronounce...

    Authors: S. K. B. Spohn, S. Adebahr, M. Huber, C. Jenkner, R. Wiehle, B. Nagavci, C. Schmucker, E. G. Carl, R. C. Chen, W. A. Weber, M. Mix, A. Rühle, T. Sprave, N. H. Nicolay, C. Gratzke, M. Benndorf…
    Citation: BMC Cancer 2022 22:337

Featured videos

View featured videos from across the BMC-series journals