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  1. Cancer is widely recognized as a global public health problem. Breast, prostate, and cervical cancer are among the most frequent types in developing countries. Assessing their incidence and mortality by region...

    Authors: Juliana Alexandra Hernández Vargas, Paula Ximena Ramírez Barbosa, Ana Milena Gil Quijano, Ana María Valbuena, Lizbeth Acuña and Jaime Alberto González

    Citation: BMC Cancer 2020 20:1097

    Content type: Research article

    Published on:

  2. The incidence of thyroid cancer (TC) has increased rapidly over the past few decades in Korea. This study investigated whether the TC epidemic has been driven by overdiagnosis.

    Authors: Hee-Yeon Kang, Ikhan Kim, Yeon-Yong Kim, Jinwook Bahk and Young-Ho Khang

    Citation: BMC Cancer 2020 20:1096

    Content type: Research article

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  4. This study aimed to evaluate the prognostic impact of nutritional and inflammatory measures (controlling nutritional status (CONUT) score, prognostic nutritional index (PNI), and modified Glasgow prognostic sc...

    Authors: Yasuyuki Takamizawa, Dai Shida, Narikazu Boku, Yuya Nakamura, Yuka Ahiko, Takefumi Yoshida, Taro Tanabe, Atsuo Takashima and Yukihide Kanemitsu

    Citation: BMC Cancer 2020 20:1092

    Content type: Research article

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  5. Eligibility criteria are a critical part of clinical trials, as they define the patient population under investigation. Besides certain patient characteristics, clinical trials often include biomarker testing ...

    Authors: Hanna Huebner, Christian M. Kurbacher, Geoffrey Kuesters, Andreas D. Hartkopf, Michael P. Lux, Jens Huober, Bernhard Volz, Florin-Andrei Taran, Friedrich Overkamp, Hans Tesch, Lothar Häberle, Diana Lüftner, Markus Wallwiener, Volkmar Müller, Matthias W. Beckmann, Erik Belleville…

    Citation: BMC Cancer 2020 20:1091

    Content type: Research article

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  6. All-trans retinoic acid (ATRA)-based treatment of acute promyelocytic leukemia (APL) is the most successful pharmacological treatment of acute myeloid leukemia (AML). Recent development of inhibitors of mutated i...

    Authors: Vilma Dembitz, Hrvoje Lalic, Ivan Kodvanj, Barbara Tomic, Josip Batinic, Klara Dubravcic, Drago Batinic, Antonio Bedalov and Dora Visnjic

    Citation: BMC Cancer 2020 20:1090

    Content type: Research article

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  7. Autologous stem cell transplantation (ASCT) is a well-established approach to treatment of patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) recommended by both the European Society for Medical Onc...

    Authors: Anna Sureda, Marc André, Peter Borchmann, Maria G. da Silva, Christian Gisselbrecht, Theodoros P. Vassilakopoulos, Pier Luigi Zinzani and Jan Walewski

    Citation: BMC Cancer 2020 20:1088

    Content type: Review

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  8. For patients with multiple myeloma (MM), each additional line of therapy (LOT) is associated with lower response rates, shorter treatment duration and treatment-free intervals, and increased rates of toxicitie...

    Authors: Rafael Fonseca, Saad Z. Usmani, Maneesha Mehra, Mary Slavcev, Jianming He, Sarah Cote, Annette Lam, Jon Ukropec, Eric M. Maiese, Sandhya Nair, Ravi Potluri and Peter M. Voorhees

    Citation: BMC Cancer 2020 20:1087

    Content type: Research article

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  9. Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden is expected to increase along with ongoing westernized behaviors and lifestyle. The etiology of CRC remains elusive a...

    Authors: Mouadh Barbirou, Henok G. Woldu, Ikram Sghaier, Sinda A. Bedoui, Amina Mokrani, Radhia Aami, Amel Mezlini, Besma Yacoubi-Loueslati, Peter J. Tonellato and Balkiss Bouhaouala-Zahar

    Citation: BMC Cancer 2020 20:1086

    Content type: Research article

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  10. Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is normally detectable in embryonic tissues and absent in adult tissues. ROR1 was shown to inhibit apoptosis, potentiate EGFR signaling and reported to be...

    Authors: Giovanna Schiavone, Samantha Epistolio, Vittoria Martin, Francesca Molinari, Jessica Barizzi, Luca Mazzucchelli, Milo Frattini and Luciano Wannesson

    Citation: BMC Cancer 2020 20:1085

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:1196

  11. Tools based on diagnostic prediction models are available to help general practitioners (GP) diagnose colorectal cancer. It is unclear how well they perform and whether they lead to increased or quicker diagno...

    Authors: Bogdan Grigore, Ruth Lewis, Jaime Peters, Sophie Robinson and Christopher J. Hyde

    Citation: BMC Cancer 2020 20:1084

    Content type: Research article

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  12. Although great progress has been made in treatment regimens, cervical cancer remains as one of the most common cancer in women worldwide. Studies focusing on molecules that regulate carcinogenesis may provide ...

    Authors: Nehla Banu, Annie Riera-Leal, Jesse Haramati, Pablo Cesar Ortiz-Lazareno, Sandeep Surendra Panikar, Blanca Estela Bastidas-Ramirez, Gloria Yareli Gutierrez-Silerio, Fabiola Solorzano-Ibarra, Martha Cecilia Tellez-Bañuelos, Jorge Gutierrez-Franco, Miriam Ruth Bueno-Topete, Ana Laura Pereira-Suarez and Susana del Toro-Arreola

    Citation: BMC Cancer 2020 20:1083

    Content type: Research article

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  13. The ability to detect tumor-specific biomarkers in real-time using optical imaging plays a critical role in preclinical studies aimed at evaluating drug safety and treatment response. In this study, we enginee...

    Authors: Harini Kantamneni, Shravani Barkund, Michael Donzanti, Daniel Martin, Xinyu Zhao, Shuqing He, Richard E. Riman, Mei Chee Tan, Mark C. Pierce, Charles M. Roth, Vidya Ganapathy and Prabhas V. Moghe

    Citation: BMC Cancer 2020 20:1082

    Content type: Research article

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  14. A secondary malignancy is the most serious complication in lung cancer (LC) survivors. This study aimed to evaluate the clinicopathological features, predictable risk factors and survival of patients with LC w...

    Authors: Huabin Wang, Yin Yin, Ru Wang, Junbin Huang, Hongman Xue, Yucai Cheng, Lidan Zhang and Chun Chen

    Citation: BMC Cancer 2020 20:1081

    Content type: Research article

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  15. Little is known about the presentation, help seeking behaviour for breast cancer in Singapore. Nor was there a study exploring the experience of patients in their breast cancer journey.

    Authors: Celene W. Q. Ng, Jennifer N. W. Lim, Jenny Liu and Mikael Hartman

    Citation: BMC Cancer 2020 20:1080

    Content type: Research article

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  16. In recent years, the identification of genetic and phenotypic biomarkers of cancer for prevention, early diagnosis and patient stratification has been a main objective of research in the field. Different multi...

    Authors: J. C. Triviño, A. Ceba, E. Rubio-Solsona, D. Serra, I. Sanchez-Guiu, G. Ribas, R. Rosa, M. Cabo, L. Bernad, G. Pita, A. Gonzalez-Neira, G. Legarda, J. L. Diaz, A. García-Vigara, A. Martínez-Aspas, M. Escrig…

    Citation: BMC Cancer 2020 20:1079

    Content type: Research article

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  17. In low-income countries breast cancer awareness (BCA) is essential to reduce the proportion of advanced stage presentations of breast cancer. There is a lack of studies using multivariable techniques to explor...

    Authors: Rukaiya Malik, Numa Vera, Chandra Dayal, Abhay Choudhari, Jyotishna Mudaliar, Amanda Noovao Hill, Ilisapeci Kubuabola and Ronny Gunnarsson

    Citation: BMC Cancer 2020 20:1078

    Content type: Research article

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  18. The purpose of this study was to assess trends in incidence and presentation of colorectal cancer (CRC) over a period of 37 years in a stable population in Mid-Norway. Secondarily, we wanted to predict the fut...

    Authors: Øystein Høydahl, Tom-Harald Edna, Athanasios Xanthoulis, Stian Lydersen and Birger Henning Endreseth

    Citation: BMC Cancer 2020 20:1077

    Content type: Research article

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  19. Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype with basal features, lacking the expression of receptors targeted successfully in other breast cancer subtypes. Treatment response to...

    Authors: Alexander Ring, Pushpinder Kaur and Julie E. Lang

    Citation: BMC Cancer 2020 20:1076

    Content type: Research article

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  20. Resistance to chemotherapy is the most common cause of treatment failure in acute myeloid leukemia (AML) and the drug efflux pump ABCB1 is a critical mediator. Recent studies have identified promoter transloca...

    Authors: Mark S. Williams, Naseer J. Basma, Fabio M. R. Amaral, Gillian Williams, John P. Weightman, Wolfgang Breitwieser, Louisa Nelson, Stephen S. Taylor, Daniel H. Wiseman and Tim C. P. Somervaille

    Citation: BMC Cancer 2020 20:1075

    Content type: Research article

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  21. Breast cancer (BC) is a major public health issue. More than one out of five women treated for breast cancer will develop lymphedema in an upper extremity. Current evidence advocates transdisciplinary oncologi...

    Authors: María Nieves Muñoz-Alcaraz, Luis Ángel Pérula-de-Torres, Jesús Serrano-Merino, Antonio José Jiménez-Vílchez, María Victoria Olmo-Carmona, María Teresa Muñoz-García, Cruz Bartolomé-Moreno, Bárbara Oliván-Blázquez and Rosa Magallón-Botaya

    Citation: BMC Cancer 2020 20:1074

    Content type: Study protocol

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  22. The clinicopathological classification of breast cancer is proposed according to therapeutic purposes. It is simplified and can be conducted easily in clinical practice, and this subtyping undoubtedly contribu...

    Authors: Ming Ni, Xiaoming Zhou, Jingwei Liu, Haiyang Yu, Yuanxiang Gao, Xuexi Zhang and Zhiming Li

    Citation: BMC Cancer 2020 20:1073

    Content type: Research article

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  23. The nuclear transport system has been proposed to be indispensable for cell proliferation and invasion in cancers. Prognostic biomarkers and molecular targets in nuclear transport systems have been developed. ...

    Authors: Zheng Zhu, Yang Lan, Lihong Wang, Jia Ge, Jiao Wang, Feng Liu, Zhicheng He, Hua Zhang, Min Luo, Dandan Lin, Yaoyao Tan, Yuanyuan Xu and Tao Luo

    Citation: BMC Cancer 2020 20:1072

    Content type: Research article

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  24. Colon cancer is the most common type of gastrointestinal cancer and has high morbidity and mortality. Colon adenocarcinoma (COAD) is the main pathological type of colon cancer, and much evidence has supported ...

    Authors: Jihang Luo, Puyu Liu, Leibo Wang, Yi Huang, Yuanyan Wang, Wenjing Geng, Duo Chen, Yuju Bai and Ze Yang

    Citation: BMC Cancer 2020 20:1071

    Content type: Research article

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  25. There is uncertainty about the effectiveness of clinical breast examination (CBE) and conflicting recommendations regarding its usefulness as a screening tool for breast cancer. This paper provides an overview...

    Authors: Tran Thu Ngan, Nga T. Q. Nguyen, Hoang Van Minh, Michael Donnelly and Ciaran O’Neill

    Citation: BMC Cancer 2020 20:1070

    Content type: Research article

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  26. Melanoma is the most aggressive type of skin cancer and is associated with environmental and genetic risk factors. It originates in melanocytes, the pigment-producing cells. Single nucleotide polymorphisms (SN...

    Authors: Larissa B. Reis, Renato M. Bakos, Fernanda S. L. Vianna, Gabriel S. Macedo, Vanessa C. Jacovas, André M. Ribeiro-dos-Santos, Sidney Santos, Lúcio Bakos and Patricia Ashton-Prolla

    Citation: BMC Cancer 2020 20:1069

    Content type: Research article

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  27. S-1 and cyclophosphamide (CPA) can be given orally, and their combination may have great potential for treating metastatic breast cancer (MBC). A phase I study of sequential S-1 and CPA therapy was conducted i...

    Authors: Keiko Yanai, Takaaki Fujii, Jun Horiguchi, Yuko Nakazawa, Sasagu Kurozumi, Sayaka Obayashi, Reina Yajima and Ken Shirabe

    Citation: BMC Cancer 2020 20:1068

    Content type: Research article

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  28. Estimating the risk of lymph node metastasis (LNM) is crucial for determining subsequent treatments following curative resection of early colorectal cancer (ECC). This multicenter study analyzed the risk facto...

    Authors: Chunyan Zeng, Dandan Xiong, Fei Cheng, Qingtian Luo, Qiang Wang, Jun Huang, Guilian Lan, Huan Zhong and Youxiang Chen

    Citation: BMC Cancer 2020 20:1067

    Content type: Research article

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  29. Heterogeneity of metastatic renal cell carcinoma (RCC) constraints accurate prognosis prediction of the tumor. We therefore aimed at developing a novel nomogram for accurate prediction of overall survival (OS)...

    Authors: Wenwen Zheng, Weiwei Zhu, Shengqiang Yu, Kangqi Li, Yuexia Ding, Qingna Wu, Qiling Tang, Quan Zhao, Congxiao Lu and Chenyu Guo

    Citation: BMC Cancer 2020 20:1066

    Content type: Research article

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  30. Pancreatic cancer is a malignant tumor with high mortality. Acidic nuclear phosphoprotein 32 family member E (ANP32E), a specific H2A.Z chaperone, has been shown to contribute to breast cancer development. How...

    Authors: Jianwei Zhang, Zhongmin Lan, Guotong Qiu, Hu Ren, Yajie Zhao, Zongting Gu, Zongze Li, Lin Feng, Jin He and Chengfeng Wang

    Citation: BMC Cancer 2020 20:1065

    Content type: Research article

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  31. Immunomodulatory activities of human mesenchymal stromal /stem cells (hMSCs) has been widely recognized as the most critical function of hMSCs for exerting its therapeutic effects. However, the detailed mechan...

    Authors: Tao Na, Kehua Zhang and Bao-Zhu Yuan

    Citation: BMC Cancer 2020 20:1064

    Content type: Research article

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  32. Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited systemic treatment options. RX-5902 is a novel anti-cancer agent that inhibits phosphorylated-p68 and thus attenuates nu...

    Authors: John J. Tentler, Julie Lang, Anna Capasso, Deog Joong Kim, Ely Benaim, Young B. Lee, Andrew Eisen, Stacey M. Bagby, Sarah J. Hartman, Betelehem W. Yacob, Brian Gittleman, Todd M. Pitts, Roberta Pelanda, S. Gail Eckhardt and Jennifer R. Diamond

    Citation: BMC Cancer 2020 20:1063

    Content type: Research article

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  33. Extensive research has revealed that genes play a pivotal role in tumor development and growth. However, the underlying involvement of gene expression in gastric carcinoma (GC) remains to be investigated further.

    Authors: Zhenhua Yin, Dejun Wu, Jianping Shi, Xiyi Wei, Nuyun Jin, Xiaolan Lu and Xiaohan Ren

    Citation: BMC Cancer 2020 20:1062

    Content type: Research article

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    The Correction to this article has been published in BMC Cancer 2020 20:1141

  34. Diffuse large B cell lymphoma (DLBCL) is the commonest lymphoma that is highly aggressive where one-third of the patients relapse despite effective treatment. Interaction between the lymphoma cells and the non...

    Authors: Sewa Rijal, Johanna Kok, Caitlin Coombes, Lillian Smyth, Jayde Hourigan, Sanjiv Jain and Dipti Talaulikar

    Citation: BMC Cancer 2020 20:1061

    Content type: Research article

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  35. Intraventricular neuroepithelial tumors (IVT) are rare lesions and comprise different pathological entities such as ependymomas, subependymomas and central neurocytomas. The treatment of choice is neurosurgica...

    Authors: A. Kaywan Aftahy, Melanie Barz, Philipp Krauss, Friederike Liesche, Benedikt Wiestler, Stephanie E. Combs, Christoph Straube, Bernhard Meyer and Jens Gempt

    Citation: BMC Cancer 2020 20:1060

    Content type: Research article

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  38. Hypoxic tumors are known to be highly resistant to radiotherapy and cause poor prognosis in non-small cell lung cancer (NSCLC) patients. CKD-516, a novel vascular disrupting agent (VDA), mainly affects blood v...

    Authors: Min-Young Kim, Jung-Young Shin, Jeong-Oh Kim, Kyoung-Hwa Son, Yeon Sil Kim, Chan Kwon Jung and Jin-Hyoung Kang

    Citation: BMC Cancer 2020 20:1057

    Content type: Research article

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  39. In general, human papillomavirus (HPV) vaccines have demonstrated efficacy in young women worldwide, but there is limited evidence on the efficacy of the quadrivalent HPV6/11/16/18 vaccine in adult women and n...

    Authors: Tetsuji Kurokawa, Makoto Yamamoto, Toshimichi Onuma, Hideaki Tsuyoshi, Akiko Shinagawa, Yoko Chino and Yoshio Yoshida

    Citation: BMC Cancer 2020 20:1056

    Content type: Study protocol

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  41. Chondrosarcoma (CS) most commonly involves the pelvis. This study aimed to analyze differences in clinical characteristics and prognostic factors between primary and secondary conventional pelvic CS, and provi...

    Authors: Jie Zang, Wei Guo, Rongli Yang, Xiaodong Tang and Haijie Liang

    Citation: BMC Cancer 2020 20:1054

    Content type: Research article

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  42. Germline TP53 mutations are associated with Li-Fraumeni syndrome, a severe and rare hereditary cancer syndrome. Despite the rarity of germline TP53 mutations, the clinical implication for mutation carriers and th...

    Authors: Ava Kwong, Vivian Yvonne Shin, Cecilia Y. S. Ho, Chun Hang Au, Thomas P. Slavin, Jeffrey N. Weitzel, Tsun-Leung Chan and Edmond S. K. Ma

    Citation: BMC Cancer 2020 20:1053

    Content type: Research article

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  43. Triple-Negative Breast Cancer (TNBC) is an aggressive and complex subtype of breast cancer. The current biomarkers used in the context of breast cancer treatment are highly dependent on the targeting of oestro...

    Authors: Gyeong Back Lim, Young-Ae Kim, Jeong-Han Seo, Hee Jin Lee, Gyungyub Gong and Sung Hee Park

    Citation: BMC Cancer 2020 20:1052

    Content type: Research article

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  45. This analysis aims to evaluate health-related quality of life (HrQoL) (primary outcome for this analysis), nausea and vomiting, and pain in patients with inoperable malignant bowel obstruction (IMBO) due to ca...

    Authors: Nikki McCaffrey, Tegan Asser, Belinda Fazekas, Wendy Muircroft, Meera Agar, Katherine Clark, Simon Eckermann, Jessica Lee, Rohit Joshi, Peter Allcroft, Caitlin Sheehan and David C. Currow

    Citation: BMC Cancer 2020 20:1050

    Content type: Research article

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  46. Measurement of serum human epidermal growth factor receptor-2 (HER-2/neu) levels might play an essential role as a diagnostic/screening marker for the early selection of therapeutic approaches and predict prognos...

    Authors: Amir Shamshirian, Amir Reza Aref, George W. Yip, Majid Ebrahimi Warkiani, Keyvan Heydari, Sajad Razavi Bazaz, Zeinab Hamzehgardeshi, Danial Shamshirian, Mahmood Moosazadeh and Reza Alizadeh-Navaei

    Citation: BMC Cancer 2020 20:1049

    Content type: Research article

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  48. This study explored the diagnostic power of preoperative circulating tumor cells (CTCs) for the presence of microvascular invasion (MVI) and the relationship between dynamic changes in postoperative CTCs and p...

    Authors: Jiangmin Zhou, Zhiwei Zhang, Honghao Zhou, Chao Leng, Bingwu Hou, Chenyang Zhou, Xinsheng Hu, Jinlin Wang and Xiaoping Chen

    Citation: BMC Cancer 2020 20:1047

    Content type: Research article

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  49. Lung adenocarcinoma (LUAD) remains a crucial factor endangering human health. Gene-based clinical predictions could be of great help for cancer intervention strategies. Here, we tried to build a gene-based sur...

    Authors: Yanlu Xiong, Jie Lei, Jinbo Zhao, Qiang Lu, Yangbo Feng, Tianyun Qiao, Shaowei Xin, Yong Han and Tao Jiang

    Citation: BMC Cancer 2020 20:1046

    Content type: Research article

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  50. The effect of tumor size on account of long-term survival results in perihilar cholangiocarcinoma (PCCA) patients has remained a controversial debate. It is urgent necessary to identify the optimal cutoff valu...

    Authors: Yaodong Zhang, Zhengshan Wu, Xing Wang, Changxian Li, Jiang Chang, Wangjie Jiang, Hongwei Wang, Yirui Wang and Xiangcheng Li

    Citation: BMC Cancer 2020 20:1044

    Content type: Research article

    Published on:

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