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  1. Age-adjusted US total pediatric cancer incidence rates (TPCIR) rose 49% 1975–2015 for unknown reasons. Prenatal cannabis exposure has been linked with several pediatric cancers which together comprise the majo...

    Authors: Albert Stuart Reece and Gary Kenneth Hulse

    Citation: BMC Cancer 2021 21:197

    Content type: Research article

    Published on:

  2. The benefits of adjuvant chemotherapy for elderly patients with gastric cancer (GC) remain unknown because elderly patients are underrepresented in most clinical trials. This study aimed to evaluate the effect...

    Authors: Yanrui Liang, Liying Zhao, Hao Chen, Tian Lin, Tao Chen, Mingli Zhao, Yanfeng Hu, Jiang Yu, Hao Liu and Guoxin Li

    Citation: BMC Cancer 2021 21:196

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:298

  3. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Athanasios Tampakis, Ekaterini-Christina Tampaki, Afrodite Nonni, Ioannis D. Kostakis, Alberto Posabella, Konstantinos Kontzoglou, Markus von Flüe, Evangelos Felekouras, Gregory Kouraklis and Nikolaos Nikiteas

    Citation: BMC Cancer 2021 21:191

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2021 21:153

  4. Genome-wide association studies (GWAS) have identified multiple common CRC-related (colorectal cancer) SNPs (single nucleotide polymorphisms) including the Cadherin 1(CDH1) rs9929218 may act by increasing the ...

    Authors: Huiyan Wang, Dongying Gu, Miao Yu, Yanjun Hu, Zhe Chen, Xinying Huo, Tao Yu, Jinfei Chen and Yang Zheng

    Citation: BMC Cancer 2021 21:190

    Content type: Research article

    Published on:

  5. The present study aims to evaluate the efficacy and safety of apatinib monotherapy or combination therapy for patients with advanced or recurrent biliary tract cancer (BTC).

    Authors: Caiyun Nie, Huifang Lv, Yishu Xing, Beibei Chen, Weifeng Xu, Jianzheng Wang and Xiaobing Chen

    Citation: BMC Cancer 2021 21:189

    Content type: Research article

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  6. Gastric outlet obstruction (GOO) is a late complication of advanced gastric cancer, and it is controversial how to select the therapeutic strategies: gastrojejunostomy and palliative gastrectomy? Therefore, th...

    Authors: Xiao-Jiang Chen, Guo-Ming Chen, Yi-Cheng Wei, Hong Yu, Xi-Cheng Wang, Zhou-Kai Zhao, Tian-Qi Luo, Run-Cong Nie and Zhi-Wei Zhou

    Citation: BMC Cancer 2021 21:188

    Content type: Research article

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  7. Super-enhancer-associated long noncoding RNAs (SE-lncRNAs) have been reported to play essential roles in tumorigenesis, but the fundamental mechanism of SE-lncRNAs in colorectal cancer (CRC) remains largely un...

    Authors: Linping Yan, Huanhuan Chen, Li Tang, Pan Jiang and Feng Yan

    Citation: BMC Cancer 2021 21:187

    Content type: Research article

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  8. Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2) is a microtubule associated protein that functions in mitotic spindle assembly. TPX2 also localizes to the nucleus where it functions in DNA damage r...

    Authors: Daniel R. Matson, Ryan A. Denu, Lauren M. Zasadil, Mark E. Burkard, Beth A. Weaver, Christopher Flynn and P. Todd Stukenberg

    Citation: BMC Cancer 2021 21:186

    Content type: Research article

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  9. The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both progranulin and its receptor sortilin are known to be ...

    Authors: Karoline Berger, Sara Rhost, Svanheiður Rafnsdóttir, Éamon Hughes, Ylva Magnusson, Maria Ekholm, Olle Stål, Lisa Rydén and Göran Landberg

    Citation: BMC Cancer 2021 21:185

    Content type: Research article

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  11. Establishing diagnostic and prognostic biomarkers of primary central nervous system lymphoma (PCNSL) is a challenge. This study evaluated the value of dynamic interleukin (IL)-10 cerebrospinal fluid (CSF) conc...

    Authors: Yan Zhang, Dongmei Zou, Jingjing Yin, Li Zhang, Xiao Zhang, Wei Wang, Meifen Zhang, Daobin Zhou and Wei Zhang

    Citation: BMC Cancer 2021 21:183

    Content type: Research article

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  12. Bone-targeted agents (BTAs) are widely used in the management of patients with bone metastases from solid tumors. Knowledge of the impact of their routine care use on patient-reported pain and bone pain-relate...

    Authors: Karin Ribi, Beat Thürlimann, Corinne Schär, Daniel Dietrich, Richard Cathomas, Ursina Zürrer-Härdi, Thomas von Briel, Sandro Anchisi, Pierre Bohanes, Veronika Blum, Philippe von Burg, Meinrad Mannhart, Clemens B. Caspar, Roger von Moos and Michael Mark

    Citation: BMC Cancer 2021 21:182

    Content type: Research article

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  13. Mutation analysis using next-generation sequencing highlights the features of tumors with somatic alterations. However, the mutation profile of double cancer remains unclear. Here, we analyzed tumors derived f...

    Authors: Keiichi Hatakeyama, Takeshi Nagashima, Akifumi Notsu, Keiichi Ohshima, Sumiko Ohnami, Shumpei Ohnami, Yuji Shimoda, Akane Naruoka, Koji Maruyama, Akira Iizuka, Tadashi Ashizawa, Hirotsugu Kenmotsu, Tohru Mochizuki, Kenichi Urakami, Yasuto Akiyama and Ken Yamaguchi

    Citation: BMC Cancer 2021 21:181

    Content type: Research article

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  14. Aberrant activation of the Wnt/β-catenin signaling pathway is one of the most frequent abnormalities in human cancer, including colorectal cancer (CRC). Previous studies revealed pivotal functions of WNT famil...

    Authors: Shuai Jiang, Qiwen Li, Yimin Liu, Huimin Zhang, Qianyu Wang, Yu Chen, Xiaoyang Shi, Jun Li, Hailing Zhang, Yi Zhang, Dongqing Xia, Man Wu, Jiajia Lin, Chenglin Zhang, Suhua Pang, Jiamin Jiang…

    Citation: BMC Cancer 2021 21:180

    Content type: Research article

    Published on:

  15. The management of unresectable locally advanced colon cancer (LACC) remains controversial, as resection is not feasible. The goal of this study was to evaluate the treatment outcomes and toxicity of neoadjuvan...

    Authors: Yan Yuan, Wei-Wei Xiao, Wei-Hao Xie, Pei-Qiang Cai, Qiao-Xuan Wang, Hui Chang, Bao-Qing Chen, Wen-Hao Zhou, Zhi-Fan Zeng, Xiao-Jun Wu, Qing Liu, Li-Ren Li, Rong Zhang and Yuan-Hong Gao

    Citation: BMC Cancer 2021 21:179

    Content type: Research article

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  16. Early detection and diagnosis of parotid gland cancer (PGC) are essential to improve clinical outcomes, because Tumor-Node-Metastasis stage at diagnosis is a very strong indicator of prognosis in PGC. Neverthe...

    Authors: Sung Yong Choi, Eunkyu Lee, Eunhye Kim, Man Ki Chung, Young-Ik Son, Chung-Hwan Baek and Han-Sin Jeong

    Citation: BMC Cancer 2021 21:178

    Content type: Research article

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  17. Transplantation-related mortality (TRM) is a major obstacle in allogeneic hematopoietic cell transplantation (allo-HCT). Approximately 60–80% of TRM occurs early, within 100 days of transplantation.

    Authors: Seom Gim Kong, Seri Jeong, Sangjin Lee, Jee-Yeong Jeong, Da Jung Kim and Ho Sup Lee

    Citation: BMC Cancer 2021 21:177

    Content type: Research article

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  20. Cisplatin (CDDP) significantly prolongs survival in various cancers, but many patients also develop resistance that results in treatment failure. Thus, this study aimed to elucidate the underlying mechanisms b...

    Authors: Jing Guo, Kiyotoshi Satoh, Sho Tabata, Masaru Mori, Masaru Tomita and Tomoyoshi Soga

    Citation: BMC Cancer 2021 21:174

    Content type: Research article

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  21. The standard to ensure utmost cancer treatment is a prerequisite in national cancer plans for comprehensive cancer centers (CCCs) and ensured through multidisciplinary tumor boards (MTBs). Despite these being ...

    Authors: Monika Engelhardt, Gabriele Ihorst, Martin Schumacher, Michael Rassner, Laura Gengenbach, Mandy Möller, Khalid Shoumariyeh, Jakob Neubauer, Juliane Farthmann, Georg Herget and Ralph Wäsch

    Citation: BMC Cancer 2021 21:173

    Content type: Correspondence

    Published on:

    The original article was published in BMC Cancer 2020 20:355

  22. Colibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli strains harboring the pks island. Human and animal studies have shown that colib...

    Authors: Manon Oliero, Annie Calvé, Gabriela Fragoso, Thibault Cuisiniere, Roy Hajjar, Ulrich Dobrindt and Manuela M. Santos

    Citation: BMC Cancer 2021 21:172

    Content type: Research article

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  23. There is uncertainty in the literature about preserving the left colic artery (LCA) during low anterior resection for rectal cancer. We analyzed the effect of preserving the LCA on long-term oncological outcomes.

    Authors: Yuwen Luo, Rongjiang Li, Deqing Wu, Jun Zeng, Junjiang Wang, Xianzhe Chen, Chengzhi Huang, Yong Li and Xueqing Yao

    Citation: BMC Cancer 2021 21:171

    Content type: Research article

    Published on:

  24. The concept of personalized therapy has been proven to be a promising approach. A popular technique is to utilize gold nanoparticles (AuNPs) as drug delivery vectors for cytotoxic drugs and small molecule inhi...

    Authors: Hend M. Abdel Hamid, Zeinab E. Darwish, Sahar M. Elsheikh, Ghada M. Mourad, Hanaa M. Donia and Marwa M. Afifi

    Citation: BMC Cancer 2021 21:170

    Content type: Research article

    Published on:

  25. Numerous studies emphasize the positive effects of physical activity on health and well-being in cancer patients. The effects of physical activity on the working lives of cancer patients have received less att...

    Authors: Rikke Rosbjerg, Robert Zachariae, Dorte Gilså Hansen, Inger Hoejris, Saskia Duijts, Nina Lykkegaard Gehr, Irene Dyhrberg Andersen and Merete Labriola

    Citation: BMC Cancer 2021 21:169

    Content type: Research article

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  26. The prognositc factors in patient with invasive cribriform carcinoma (ICC) of breast is still remain controversal. The study aims to establish a nomogram to predict the survival outcomes in patients with ICC b...

    Authors: Jiameng Liu, Xiaobin Zheng, Zhonghua Han, Shunguo Lin, Hui Han and Chunsen Xu

    Citation: BMC Cancer 2021 21:168

    Content type: Research article

    Published on:

  27. Radiotherapy is the mainstay of brain metastasis (BM) management. Radiation necrosis (RN) is a serious complication of radiotherapy. Bevacizumab (BV), an anti-vascular endothelial growth factor monoclonal anti...

    Authors: Muhammad Khan, Zhihong Zhao, Sumbal Arooj and Guixiang Liao

    Citation: BMC Cancer 2021 21:167

    Content type: Research article

    Published on:

  28. Although fat necrosis is a minor postoperative complication after breast reconstruction, occasionally it mimics to tumor recurrence in patients with breast cancer. Therefore, the surgeon should distinguish bet...

    Authors: Jeeyeon Lee, Ho Yong Park, Wan Wook Kim, Jeong Ju Lee, Hee Jung Keum, Jung Dug Yang, Jeong Woo Lee, Joon Seok Lee and Jin Hyang Jung

    Citation: BMC Cancer 2021 21:166

    Content type: Research article

    Published on:

  29. The current management guidelines recommend that patients with borderline resectable pancreatic adenocarcinoma (BRPC) should initially receive neoadjuvant chemotherapy. The addition of advanced radiation thera...

    Authors: Salvatore Paiella, Giuseppe Malleo, Nicola Simoni, Renato Micera, Stefania Guariglia, Carlo Cavedon, Giovanni Marchegiani, Alessandro Esposito, Luca Landoni, Luca Casetti, Massimiliano Tuveri, Michele Milella, Erica Secchettin, Gessica Manzini, Chiara Bovo, Matteo De Pastena…

    Citation: BMC Cancer 2021 21:165

    Content type: Study protocol

    Published on:

  30. Activating Gαq signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled receptor CysLT

    Authors: Rogier J. Nell, Nino V. Menger, Mieke Versluis, Gregorius P. M. Luyten, Robert M. Verdijk, Michele C. Madigan, Martine J. Jager and Pieter A. van der Velden

    Citation: BMC Cancer 2021 21:164

    Content type: Research article

    Published on:

  31. Ovarian cancer (OC) is a life-threatening gynecological malignancy where dysregulation of microRNAs (miRNAs) is frequently implicated. This study focuses on the function of miR-545 on OC development and the mo...

    Authors: Hailing Zhang, Ke Zhang, Zhen Xu, Zhilong Chen, Qian Wang, Chenyang Wang and Jinquan Cui

    Citation: BMC Cancer 2021 21:163

    Content type: Research article

    Published on:

  32. Urothelial carcinoma (UC) is the most common genitourinary malignancy in China. In this study, we surveyed the genomic features in Chinese UC patients and investigated the concordance of genetic alterations be...

    Authors: Bo Yang, Xiao Zhao, Chong Wan, Xin Ma, Shaoxi Niu, Aitao Guo, Jieli Wang, Jinliang Wang, Decong Sun and Shunchang Jiao

    Citation: BMC Cancer 2021 21:162

    Content type: Research article

    Published on:

  33. Early screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in H...

    Authors: Li Zhang, Hao Niu, Ping Yang, Jie Ma, Bao-Ying Yuan, Zhao-Chong Zeng and Zuo-Lin Xiang

    Citation: BMC Cancer 2021 21:161

    Content type: Research article

    Published on:

  34. BCL2 associated Athano-Gene 1 (BAG1) has been described to be involved in the development and progression of cancer. But the role of BAG1 in kidney renal clear cell carcinoma (KIRC) has remained largely unknown.

    Authors: Hongrong Wu, Minjing Liu, Yuejun He, Guozhao Meng, Wanbei Guo and Qiong Guo

    Citation: BMC Cancer 2021 21:160

    Content type: Research article

    Published on:

  35. Advanced lung cancer patients face significant physical and psychological burden leading to reduced physical function and quality of life. Separately, physical activity, nutrition, and palliative symptom manag...

    Authors: Manuel Ester, S. Nicole Culos-Reed, Amane Abdul-Razzak, Julia T. Daun, Delaney Duchek, George Francis, Gwyn Bebb, Jennifer Black, Audra Arlain, Chelsia Gillis, Lyle Galloway and Lauren C. Capozzi

    Citation: BMC Cancer 2021 21:159

    Content type: Research article

    Published on:

  37. Patients with gastric cancer have an increased nutritional risk and experience a significant skeletal muscle loss after surgery. We aimed to determine whether muscle loss during the first postoperative year an...

    Authors: Kyung Won Kim, Koeun Lee, Jung-Bok Lee, Taeyong Park, Seungwoo Khang, Heeryeol Jeong, Chang-Seok Ko, Jeong-Hwan Yook, Byung-Sik Kim and In-Seob Lee

    Citation: BMC Cancer 2021 21:157

    Content type: Research article

    Published on:

  38. Matricellular glycoprotein, SPARC is a secreted molecule, that mediates the interaction between cells and extracellular matrix. SPARC functions as a regulator of matrix organization and modulates cell behavior...

    Authors: Sachiko Yoshida, Kazuo Asanoma, Hiroshi Yagi, Ichiro Onoyama, Emiko Hori, Yumiko Matsumura, Kaoru Okugawa, Hideaki Yahata and Kiyoko Kato

    Citation: BMC Cancer 2021 21:156

    Content type: Research article

    Published on:

  39. p63, a member of the p53 gene family, is an important regulator for epithelial tissue growth and development. ∆Np63α is the main isoform of p63 and highly expressed in Non-melanoma skin cancer (NMSC). Extracel...

    Authors: Eid S. Alshammari, Amjad A. Aljagthmi, Andrew J. Stacy, Mike Bottomley, H. Nicholas Shamma, Madhavi P. Kadakia and Weiwen Long

    Citation: BMC Cancer 2021 21:155

    Content type: Research article

    Published on:

  40. Uterine serous carcinoma (USC) is an aggressive type of endometrial cancer that accounts for up to 40% of endometrial cancer deaths, creating an urgent need for prognostic biomarkers.

    Authors: Hui Chen, Lingjun Li, Ping Qin, Hanzhen Xiong, Ruichao Chen, Minfen Zhang and Qingping Jiang

    Citation: BMC Cancer 2021 21:154

    Content type: Research article

    Published on:

  41. Fascin is the main actin cross-linker protein that regulates adhesion dynamics and stabilizes cell protrusion, such as filopodia. In human cancer, fascin expression correlates with aggressive clinical features...

    Authors: Athanasios Tampakis, Ekaterini-Christina Tampaki, Afrodite Nonni, Ioannis D. Kostakis, Alberto Posabella, Konstantinos Kontzoglou, Markus von Flüe, Evangelos Felekouras, Gregory Kouraklis and Nikolaos Nikiteas

    Citation: BMC Cancer 2021 21:153

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:191

  42. The goal of this study is to disclose the clinically significant genomic alterations in the Chinese and Western patients with intrahepatic cholangiocarcinoma.

    Authors: Shifeng Xu, Yuan Guo, Yanwu Zeng, Zhijian Song, Xiaodan Zhu, Ning Fan, Zhilei Zhang, Guibing Ren, Yunjin Zang and Wei Rao

    Citation: BMC Cancer 2021 21:152

    Content type: Research article

    Published on:

  44. One of the greatest success of pediatric hematology is a prominent improvement of survival in acute lymphoblastic leukemia (ALL). Therefore, special attention needs to be paid to long-term side effects of the tre...

    Authors: Slawomir Kroczka, Konrad Stepien, Izabela Witek-Motyl, Kinga Kwiecinska, Eryk Kapusta, Agnieszka Biedron, Pawel Skorek and Szymon Skoczen

    Citation: BMC Cancer 2021 21:150

    Content type: Research article

    Published on:

  46. Lung cancer remains the leading cause of cancer death globally. In 2015, the cancer classification guidelines of the World Health Organization were updated. The term “invasive mucinous adenocarcinoma (IMA)” ar...

    Authors: Yadong Wang, Jichang Liu, Cuicui Huang, Yukai Zeng, Yong Liu and Jiajun Du

    Citation: BMC Cancer 2021 21:148

    Content type: Research article

    Published on:

  47. Patients with cancer history are usually excluded from hepatocellular carcinoma (HCC) clinical trials. However, whether previous malignancy affects the oncological outcomes of HCC patients has not been fully a...

    Authors: Xuqi Sun, Lingling Li, Li Xu, Zhongguo Zhou, Jinbin Chen, Juncheng Wang, Yaojun Zhang, Dandan Hu and Minshan Chen

    Citation: BMC Cancer 2021 21:147

    Content type: Research article

    Published on:

  48. Medical centers with varying levels of expertise treat gastroenteropancreatic neuroendocrine tumors (GEP-NETs), which are relatively rare tumors. This study assesses the impact of center volume on GEP-NET trea...

    Authors: Kiwoon Baeg, Cynthia Harris, Monica S. Naparst, Eugene Ahn, Sahityasri Thapi, Jacob Martin, Sheila Rustgi, Grace Mhango, Juan Wisnivesky and Michelle Kang Kim

    Citation: BMC Cancer 2021 21:146

    Content type: Research article

    Published on:

  49. Although previous studies have discussed whether the minimally invasive esophagectomy (MIE) is superior to open surgery, the data concerning esophageal squamous cell carcinoma (ESCC) patients underwent neoadju...

    Authors: Dongni Chen, Weidong Wang, Junxian Mo, Qiannan Ren, Huikai Miao, Youfang Chen and Zhesheng Wen

    Citation: BMC Cancer 2021 21:145

    Content type: Research article

    Published on:

  50. Following optimal local therapy, adjuvant Procarbazine, Lomustine and Vincristine (PCV) improves overall survival (OS) in low-grade glioma (LGG). However, 1 year of PCV is associated with significant toxicitie...

    Authors: Rachel J. Keogh, Razia Aslam, Maeve A. Hennessy, Zac Coyne, Bryan T. Hennessy, Oscar S. Breathnach, Liam Grogan and Patrick G. Morris

    Citation: BMC Cancer 2021 21:140

    Content type: Research article

    Published on:

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