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  1. Clinical practice guidelines recommend active surveillance as the preferred treatment option for low-risk prostate cancer, but only a minority of eligible men receive active surveillance, and practice variatio...

    Authors: Shellie D. Ellis, Soohyun Hwang, Emily Morrow, Kim S. Kimminau, Kelly Goonan, Laurie Petty, Edward Ellerbeck and J. Brantley Thrasher

    Citation: BMC Cancer 2021 21:649

    Content type: Research article

    Published on:

  2. In estrogen receptor (ER)-positive breast cancer (BC), young age is associated with poor prognosis. While very young patients respond better to chemotherapy, chemotherapy is less effective in ER-positive tumor...

    Authors: Joohyun Woo, Se Jeong Oh, Jeong-Yoon Song, Byung Joo Chae, Jung Eun Choi, Jeeyeon Lee, Heung Kyu Park and Woosung Lim

    Citation: BMC Cancer 2021 21:647

    Content type: Research article

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  3. The tumour microenvironment (TME) not only plays a role during tumour progression and metastasis but also profoundly influences treatment efficacy. Environment-mediated drug resistance is a result of crosstalk...

    Authors: Xintong Lyu, Ping Wang, Qiao Qiao and Yuanjun Jiang

    Citation: BMC Cancer 2021 21:646

    Content type: Research article

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  4. Triple-negative breast cancer (TNBC) is a highly heterogeneous subtype of breast cancer, showing aggressive clinical behaviors and poor outcomes. It urgently needs new therapeutic strategies to improve the pro...

    Authors: Yiduo Liu, Linxin Teng, Shiyi Fu, Guiyang Wang, Zhengjun Li, Chao Ding, Haodi Wang and Lei Bi

    Citation: BMC Cancer 2021 21:644

    Content type: Research

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  5. Exercise is efficacious for people living after a cancer diagnosis. However, implementation of exercise interventions in real-world settings is challenging. Implementation outcomes are defined as ‘the effects ...

    Authors: Louise Czosnek, Justin Richards, Eva Zopf, Prue Cormie, Simon Rosenbaum and Nicole M. Rankin

    Citation: BMC Cancer 2021 21:643

    Content type: Research article

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  6. Ipilimumab has shown long-term overall survival (OS) in patients with advanced melanoma in clinical trials, but robust real-world evidence is lacking. We present long-term outcomes from the IMAGE study (NCT015...

    Authors: Stéphane Dalle, Laurent Mortier, Pippa Corrie, Michal Lotem, Ruth Board, Ana María Arance, Frank Meiss, Patrick Terheyden, Ralf Gutzmer, Brian Buysse, Kelly Oh, Jane Brokaw, T. Kim Le, Susan D. Mathias, Julie Scotto, Jennifer Lord-Bessen…

    Citation: BMC Cancer 2021 21:642

    Content type: Research article

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  7. FoxP3+ Regulatory T cells (Tregs) and indoleamine-2,3-dioxygenase (IDO) participate in the formation of an immunosuppressive tumor microenvironment (TME) in malignant cutaneous melanoma (CM). Recent studies ha...

    Authors: Satu Salmi, Anton Lin, Benjamin Hirschovits-Gerz, Mari Valkonen, Niina Aaltonen, Reijo Sironen, Hanna Siiskonen and Sanna Pasonen-Seppänen

    Citation: BMC Cancer 2021 21:641

    Content type: Research article

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  8. The prognosis of patients with small cell lung cancer (SCLC) is poor, most of them are in the extensive stage at the time of diagnosis, and are prone to brain metastasis. In this study, we established a nomogr...

    Authors: Qinge Shan, Jianxiang Shi, Xiaohui Wang, Jun Guo, Xiao Han, Zhehai Wang and Haiyong Wang

    Citation: BMC Cancer 2021 21:640

    Content type: Research article

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  9. Although the National Comprehensive Cancer Network (NCCN) Guidelines recommend CCRT+AC and IC + CCRT as level 2A evidence for treatment of the locoregionally advanced NPC (II-IVa), IC + CCRT+AC could also be a...

    Authors: Wei Liu, Bolong Yu, Yunfan Luo, Junzheng Li, Xiaofei Yuan, Shuting Wu, Bijun Liang, Zehong Lv, Yanfei Li, Xinyu Peng, Juan Lu, Xiaohong Peng and Xiong Liu

    Citation: BMC Cancer 2021 21:639

    Content type: Research article

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  10. The objectives of this study were to screen out cut-off age value and age-related differentially expressed genes (DEGs) in clear cell renal cell carcinoma (CCRCC) from Surveillance Epidemiology and End Results...

    Authors: Fucai Tang, Zechao Lu, Chengwu He, Hanbin Zhang, Weijia Wu and Zhaohui He

    Citation: BMC Cancer 2021 21:638

    Content type: Research article

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  11. Trials of risk estimation in breast cancer screening programmes, in order to identify women at higher risk and offer extra screening/preventive measures, are ongoing. It may also be feasible to introduce less ...

    Authors: Lorna McWilliams, Victoria G. Woof, Louise S. Donnelly, Anthony Howell, D. Gareth Evans and David P. French

    Citation: BMC Cancer 2021 21:637

    Content type: Research

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  12. Sinonasal Undifferentiated Carcinoma (SNUC) is a rare and aggressive skull base tumor with poor survival and limited treatment options. To date, targeted sequencing studies have identified IDH2 and SMARCB1 as pot...

    Authors: Molly E. Heft Neal, Andrew C. Birkeland, Apurva D. Bhangale, Jingyi Zhai, Aditi Kulkarni, Susan K. Foltin, Brittany M. Jewell, Megan L. Ludwig, Lisa Pinatti, Hui Jiang, Jonathan B. McHugh, Lawence Marentette, Erin L. McKean and J. Chad Brenner

    Citation: BMC Cancer 2021 21:636

    Content type: Research

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  13. Bladder cancer (BC) is the fourth most prevalent neoplasm in men and is associated with high tumour recurrence rates, leading to major treatment challenges. Lysine-specific demethylase 6A (KDM6A) is frequently mu...

    Authors: Xingxing Chen, Xuehua Lin, Guofu Pang, Jian Deng, Qun Xie and Zhengrong Zhang

    Citation: BMC Cancer 2021 21:635

    Content type: Research

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  14. Immunotherapy is becoming a standard of care for non-small cell lung cancer (NSCLC). Checkpoint inhibitor-associated pneumonia (CIP) is a rare and potentially life-threatening event that can occur at any time ...

    Authors: Aiben Huang, Yang Xu, Xuelei Zang, Chongchong Wu, Jie Gao, Xiaoli Sun, Mei Xie, Xidong Ma, Hui Deng, Jialin Song, Fangping Ren, Li Pang, Jin Qian, Zhaofeng Yu, Shiyu Wan, Yuanyuan Chen…

    Citation: BMC Cancer 2021 21:634

    Content type: Research

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  15. The purpose of this study was to determine the validity of the ultrasound features as well as patient characteristics assigned to B3 (uncertain malignant potential) breast lesions before vacuum-assisted excisi...

    Authors: Liang Zheng, Fufu Zheng, Zhaomin Xing, Yunjian Zhang, Yongxin Li, Hongbiao Xu, Yuanhui Lai, Jie Li and Wenjian Wang

    Citation: BMC Cancer 2021 21:633

    Content type: Research

    Published on:

  16. Pancreatic ductal adenocarcinoma (PDAC) patients suffer poor outcomes, including a five-year survival of below 10%. Poor outcomes result in part from therapeutic resistance that limits the impact of cytotoxic ...

    Authors: Ryne C. Ramaker, Andrew A. Hardigan, Emily R. Gordon, Carter A. Wright, Richard M. Myers and Sara J. Cooper

    Citation: BMC Cancer 2021 21:632

    Content type: Research

    Published on:

  17. Spatial inequalities in cancer management have been evidenced by studies reporting lower quality of care or/and lower survival for patients living in remote or socially deprived areas. NETSARC+ is a national r...

    Authors: Yohan Fayet, Raphaël Tétreau, Charles Honoré, Louis-Romée Le Nail, Cécile Dalban, François Gouin, Sylvain Causeret, Sophie Piperno-Neumann, Simone Mathoulin-Pelissier, Marie Karanian, Antoine Italiano, Loïc Chaigneau, Justine Gantzer, François Bertucci, Mickael Ropars, Esma Saada-Bouzid…

    Citation: BMC Cancer 2021 21:631

    Content type: Research

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  18. No data exist for the long-term outcome of metastatic colorectal cancer (mCRC) from the Southern part of Asia. The primary objective of the study is to evaluate the survival outcome of mCRC from an Indian tert...

    Authors: Vinod Sharma, Atul Sharma, Vinod Raina, Deepak Dabkara, Bidhu Kalyan Mohanti, N. K. Shukla, Sushmita Pathy, Sanjay Thulkar, S. V. S. Deo, Sunil Kumar and Ranjit Kumar Sahoo

    Citation: BMC Cancer 2021 21:630

    Content type: Research

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  19. Despite considerable medical proceedings, cancer is still a leading cause of death. Major problems for tumor therapy are chemoresistance as well as toxic side effects. In recent years, the additional treatment...

    Authors: Felix B. Meyer, Sophie Goebel, Sonja B. Spangel, Christiane Leovsky, Doerte Hoelzer and René Thierbach

    Citation: BMC Cancer 2021 21:629

    Content type: Research

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  20. Oral Squamous Cell Carcinoma (OSCC) results from a series of genetic alteration in squamous cells. This particular type of cancer considers one of the most aggressive malignancies to control because of its fre...

    Authors: Koel Mukherjee, Debpali Sur, Abhijeet Singh, Sandhya Rai, Neeladrisingha Das, Rakshanya Sekar, Srinu Narindi, Vandana Kumar Dhingra, Bhinyaram Jat, K. V. Vinu Balraam, Satya Prakash Agarwal and Prabhat Kumar Mandal

    Citation: BMC Cancer 2021 21:628

    Content type: Research

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  21. To explore the safety and effectiveness of delayed occlusion of the proximal inferior vena cava (DOPI) technique in retroperitoneal laparoscopic radical nephrectomy (LRN) and thrombectomy for renal tumor with ...

    Authors: Zhuo Liu, Peng Hong, Guodong Zhu, Li Zhang, Xun Zhao, Shiying Tang, Feilong Yang, Xiaojun Tian, Guoliang Wang, Shudong Zhang, Hongxian Zhang, Yi Huang, Chunxia Liu, Cheng Liu and Lulin Ma

    Citation: BMC Cancer 2021 21:627

    Content type: Research

    Published on:

  22. Lung cancer is one of the most lethal and most prevalent malignant tumors worldwide, and lung squamous cell carcinoma (LUSC) is one of the major histological subtypes. Although numerous biomarkers have been fo...

    Authors: Guichuan Huang, Jing Zhang, Ling Gong, Yi Huang and Daishun Liu

    Citation: BMC Cancer 2021 21:626

    Content type: Research article

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  23. Newcastle disease virus (NDV) is an oncolytic virus with excellent selectivity against cancer cells, both in vitro and in vivo. Unfortunately, prolonged in vitro NDV infection results in the development of per...

    Authors: Lee-Chin Chan, Jeevanathan Kalyanasundram, Sze-Wei Leong, Mas Jaffri Masarudin, Abhi Veerakumarasivam, Khatijah Yusoff, Soon-Choy Chan and Suet-Lin Chia

    Citation: BMC Cancer 2021 21:625

    Content type: Research article

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  24. Radical pancreaticoduodenectomy is the most common treatment strategy for patients diagnosed with adenocarcinoma of the pancreatic head. Few studies have reported the clinical characteristics and treatment eff...

    Authors: Chao Wu, Sheng Zhong Hou, Zuowei Wu, Xing Huang, Zihe Wang and Bole Tian

    Citation: BMC Cancer 2021 21:624

    Content type: Research article

    Published on:

  25. Rectal mucosal melanoma (RMM) is a rare and highly aggressive disease with a poor prognosis. Due to the rarity of RMM, there are few studies focusing on its genetic mechanism. This retrospective study aimed to...

    Authors: Huan Li, Lujing Yang, Yumei Lai, Xintong Wang, Xinyin Han, Siyao Liu, Dongliang Wang, Xiaojuan Li, Nana Hu, Yan Kong, Lu Si and Zhongwu Li

    Citation: BMC Cancer 2021 21:623

    Content type: Research

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  26. Pegfilgrastim, a long-acting granulocyte colony-stimulating factor (G-CSF), is commonly used to prevent febrile neutropenia (FN), a potentially life-threatening complication, following myelosuppressive chemoth...

    Authors: Reshma Mahtani, Jeffrey Crawford, Sinéad M. Flannery, Tatiana Lawrence, Jennifer Schenfeld and Prasad L. Gawade

    Citation: BMC Cancer 2021 21:621

    Content type: Research article

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  27. Treatments for soft tissue sarcoma (STS) include extensive surgical resection, radiation and chemotherapy, and can necessitate specialized care and excellent social support. Studies have demonstrated that soci...

    Authors: Boryana M. Eastman, Daniel S. Hippe, Landon S. Wootton, Matthew J. Nyflot, Matthew J. Thompson, Seth M. Pollack, Edward Kim and Matthew B. Spraker

    Citation: BMC Cancer 2021 21:620

    Content type: Research

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  28. Mitochondrial fission regulator 2 (MTFR2) was involved in the progression and development of various cancers. However, the relationship between MTFR2 with lung adenocarcinoma (LUAD) had not been reported. Here...

    Authors: Cheng Chen, Yang Tang, Wen-Dong Qu, Xu Han, Jie-Bin Zuo, Qing-Yong Cai, Gang Xu, Yong-Xiang Song and Xi-Xian Ke

    Citation: BMC Cancer 2021 21:619

    Content type: Research

    Published on:

  29. CC chemokine receptor 4 (CCR4), the receptor for CCL22 and CCL17, is expressed on the surface of effector Tregs that have the highest suppressive effects on antitumor immune response. CCR4 is also widely expre...

    Authors: Ting Zhang, Jing Sun, Jinying Li, Yunuo Zhao, Tao Zhang, Ruoning Yang and Xuelei Ma

    Citation: BMC Cancer 2021 21:618

    Content type: Research article

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  30. Lynch syndrome (LS) is an autosomal dominant hereditary cancer syndrome responsible for 2–4% of hereditary colorectal cancers (CRC). Mismatch repair protein deficiency (dMMR) is a characteristic feature of LS....

    Authors: Alice Talbot, Emily O’Donovan, Eileen Berkley, Carmel Nolan, Roisin Clarke and David Gallagher

    Citation: BMC Cancer 2021 21:617

    Content type: Research

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  31. Lung adenocarcinoma (LAC) is the predominant histologic subtype of lung cancer and has a complicated pathogenesis with high mortality. The purpose of this study was to identify differentially expressed genes (...

    Authors: Mingze Lu, Xiaowen Fan, Weilin Liao, Yijiao Li, Lijie Ma, Mu Yuan, Rui Gu, Zhengdao Wei, Chao Wang and Hua Zhang

    Citation: BMC Cancer 2021 21:616

    Content type: Research article

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  32. Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains a major public health problem and its pathogenesis remains unresolved. A recent proteomics study discovered a lipid enzyme Sterol O-acyltr...

    Authors: Yulong Chen, Xunjun Yang, Yao Chen, Guorong Chen, Cheryl A. Winkler, Ping An and Jianxin Lyu

    Citation: BMC Cancer 2021 21:615

    Content type: Research article

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  33. This study aimed to describe the incidence, clinical characteristics, and prognosis of lung cancer patients with synchronous bone metastasis (SBM) and to analyze the prognostic factors of the lung cancer patie...

    Authors: Xu Guo, Wenjuan Ma, Haixiao Wu, Yao Xu, Dezheng Wang, Shuang Zhang, Zheng Liu, Vladimir P. Chekhonin, Karl Peltzer, Jin Zhang, Xin Wang and Chao Zhang

    Citation: BMC Cancer 2021 21:613

    Content type: Research

    Published on:

  34. The study aimed to investigate the potential benefit of more than 4 courses of S1 adjuvant chemotherapy for patients with pancreatic ductal adenocarcinoma (PDAC) after surgery.

    Authors: Bo Li, Shuo Shen, Siting You, Guoxiao Zhang, Suizhi Gao, Xiaohan Shi, Huan Wang, Xiaoyi Yin, Xiongfei Xu, Shiwei Guo and Gang Jin

    Citation: BMC Cancer 2021 21:612

    Content type: Research

    Published on:

  35. Pancreatic cancer (PC) is a major cause of cancer death. In an effort to improve treatment strategies and outcomes, DNA damage repair (DDR) pathways have been introduced as a new target in PC and in other canc...

    Authors: Ilario Giovanni Rapposelli, Valentina Zampiga, Ilaria Cangini, Valentina Arcangeli, Mila Ravegnani, Martina Valgiusti, Sara Pini, Stefano Tamberi, Giulia Bartolini, Alessandro Passardi, Giovanni Martinelli, Daniele Calistri, Giovanni Luca Frassineti, Fabio Falcini and Rita Danesi

    Citation: BMC Cancer 2021 21:611

    Content type: Research

    Published on:

  36. Few studies have examined prognostic outcomes-associated molecular signatures other than overall survival (OS) for gastric cancer (GC). We aimed to identify DNA methylation biomarkers associated with multiple ...

    Authors: Jin Dai, Akihiro Nishi, Zhe-Xuan Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Wen-Qing Li and Kai-Feng Pan

    Citation: BMC Cancer 2021 21:610

    Content type: Research

    Published on:

  37. Increasing evidence indicates that site-distant metastases are associated with survival outcomes in patients with epithelial ovarian cancer. This study aimed to investigate the prognostic values of site-distan...

    Authors: Bo Wang, Shixuan Wang and Wu Ren

    Citation: BMC Cancer 2021 21:609

    Content type: Research article

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  38. Long non-coding RNA (lncRNA) plays a critical role in the malignant progression of intrahepatic cholangiocarcinoma (iCCA). This study aimed to establish a 4-lncRNA prognostic signature and explore correspondin...

    Authors: Wenbo Zou, Zizheng Wang, Fei Wang, Lincheng Li, Rong Liu and Minggen Hu

    Citation: BMC Cancer 2021 21:608

    Content type: Research

    Published on:

  39. The nuclear phosphatase mitogen-activate protein kinase phosphatase-1 (MKP-1) is a key negative regulator of the innate immune response through the regulation of the biosynthesis of proinflammatory cytokines. ...

    Authors: Ahmed Hammad, Zhao-Hong Zheng, Akhileshwar Namani, Mohamed Elshaer, Xiu Jun Wang and Xiuwen Tang

    Citation: BMC Cancer 2021 21:607

    Content type: Research

    Published on:

  40. Multiple myeloma (MM) is a major health concern. Understanding the different burden and tendency of MM in different regions is crucial for formulating specific local strategies. Therefore, we evaluated the epi...

    Authors: Linghui Zhou, Qin Yu, Guoqing Wei, Linqin Wang, Yue Huang, Kejia Hu, Yongxian Hu and He Huang

    Citation: BMC Cancer 2021 21:606

    Content type: Research

    Published on:

  41. Anemia has been a known prognostic factor in metastatic hormone-sensitive prostate cancer (mHSPC). We therefore examined the effect of anemia on the efficacy of upfront abiraterone acetate (ABI) in patients wi...

    Authors: Teppei Okamoto, Daisuke Noro, Shingo Hatakeyama, Shintaro Narita, Koji Mitsuzuka, Toshihiko Sakurai, Sadafumi Kawamura, Senji Hoshi, Jiro Shimoda, Toshikazu Tanaka, Toshiaki Kawaguchi, Shigeto Ishidoya, Akihiro Ito, Norihiko Tsuchiya, Tomonori Habuchi and Chikara Ohyama

    Citation: BMC Cancer 2021 21:605

    Content type: Research article

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  42. The dominant risk factor for urinary bladder cancer has been cigarette smoking, but, as smoking prevalence is decreasing in many populations, other risk factors may become uncovered. Such new risk factors coul...

    Authors: Kari Hemminki, Asta Försti, Akseli Hemminki, Börje Ljungberg and Otto Hemminki

    Citation: BMC Cancer 2021 21:604

    Content type: Research

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  43. Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will ...

    Authors: Tianjiao Tang, Jing Wang, Lidan Zhang, Ying Cheng, Laura Saleh, Yanni Gu and Hongbin Zhang

    Citation: BMC Cancer 2021 21:603

    Content type: Research article

    Published on:

  44. To compare the benefits and explore the cause of acquired resistance of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and its combination with chemotherapy in advanced non-small-cell lu...

    Authors: Qianqian Wang, Wen Gao, Fangyan Gao, Shidai Jin, Tianyu Qu, Fan Lin, Chen Zhang, Jingya Zhang, Zhihong Zhang, Liang Chen and Renhua Guo

    Citation: BMC Cancer 2021 21:602

    Content type: Research article

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  45. Chemotherapy induced nausea- vomiting (CINV) is considered as the most common, feared and most troublesome side effect of chemotherapy. NEPA (NEtupitant 300 mg + PAlonosetron 0.50 mg) is the first commercially...

    Authors: Bharat Vaswani, Palanki Satya Dattatreya, Sagar Bhagat, Saiprasad Patil and Hanmant Barkate

    Citation: BMC Cancer 2021 21:601

    Content type: Research article

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  46. Malignant tumor is one of the most serious diseases endangering human health. Circular RNAs play an important role in the tumorigenesis and progression of various malignant tumors. Although various studies hav...

    Authors: Fan Chao, Shiyu Wang, Cong Zhang, Dunsheng Han, Zhe Ma and Gang Chen

    Citation: BMC Cancer 2021 21:600

    Content type: Research article

    Published on:

  47. The potential reversibility of aberrant DNA methylation indicates an opportunity for oncotherapy. This study aimed to integrate methylation-driven genes and pretreatment prognostic factors and then construct a...

    Authors: Dongsheng He, Shengyin Liao, Lifang Cai, Weiming Huang, Xuehua Xie and Mengxing You

    Citation: BMC Cancer 2021 21:599

    Content type: Research article

    Published on:

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