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  1. Phase 3 oncologic randomized clinical trials (RCTs) can lead to Food and Drug Administration (FDA) approvals. In this study, we aim to identify trial-related factors associated with trials leading to subsequen...

    Authors: Joseph Abi Jaoude, Ramez Kouzy, Marc Ghabach, Roshal Patel, Dario Pasalic, Elie Ghossain, Austin B. Miller, Timothy A. Lin, Vivek Verma, C. David Fuller, Vivek Subbiah, Bruce D. Minsky, Ethan B. Ludmir and Cullen M. Taniguchi

    Citation: BMC Cancer 2021 21:695

    Content type: Research

    Published on:

  3. Liver hepatocellular carcinoma (HCC) is one of the most malignant tumors, of which prognosis is unsatisfactory in most cases and metastatic of HCC often results in poor prognosis. In this study, we aimed to co...

    Authors: Chao Chen, Yan Qun Liu, Shi Xiang Qiu, Ya Li, Ning Jun Yu, Kang Liu and Li Ming Zhong

    Citation: BMC Cancer 2021 21:693

    Content type: Research

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  5. Patients with Philadelphia-negative Myeloproliferative Neoplasms (MPN) suffer from numerous symptoms and decreased quality of life. Smoking is associated with an increased symptom burden in several malignancie...

    Authors: Sarah F. Christensen, Robyn M. Scherber, Gina L. Mazza, Amylou C. Dueck, Nana Brochmann, Christen L. Andersen, Hans C. Hasselbalch, Ruben A. Mesa and Holly L. Geyer

    Citation: BMC Cancer 2021 21:691

    Content type: Research article

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  6. Published findings suggest sex differences in lung cancer risk and a potential role for sex steroid hormones. Our aim was to perform a meta-analysis to investigate the effects of sex steroid hormone exposure s...

    Authors: Hui Zeng, Zhuoyu Yang, Jiang Li, Yan Wen, Zheng Wu, Yadi Zheng, Yiwen Yu, Yongjie Xu, Shugeng Gao, Fengwei Tan, Ni Li, Qi Xue and Jie He

    Citation: BMC Cancer 2021 21:690

    Content type: Research article

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  7. Currently biomarkers play an essential role in diagnosis, treatment, and management of cancer. In non-small cell lung cancer (NSCLC) determination of biomarkers such as ALK, EGFR, ROS1 or PD-L1 is mandatory fo...

    Authors: Ernest Nadal, Dolores Bautista, Luis Cabezón-Gutiérrez, Ana Laura Ortega, Héctor Torres, David Carcedo, Lucía Ruiz de Alda, J. Francisco Garcia, Paula Vieitez and Federico Rojo

    Citation: BMC Cancer 2021 21:689

    Content type: Research article

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  8. Low-risk human papillomavirus (HPV), such as types 6 and 11, is considered non-oncogenic, but these types have been detected in oral cancer tissue samples, suggesting their possible involvement in oral carcino...

    Authors: Karina Uehara, Yasuka Tanabe, Shintaro Hirota, Saki Higa, Zensei Toyoda, Kiyoto Kurima, Shinichiro Kina, Toshiyuki Nakasone, Akira Arasaki and Takao Kinjo

    Citation: BMC Cancer 2021 21:688

    Content type: Research article

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  9. The baculoviral IAP repeat containing 5 (BIRC5) related to epithelial-mesenchymal transition (EMT) plays a crucial role in the pathogenesis of hepatocellular carcinoma (HCC). However, it remains unclear whethe...

    Authors: Rongzhong Xu, Liubing Lin, Bo Zhang, Jian Wang, Fanchen Zhao, Xiaolin Liu, Yiping Li and Yan Li

    Citation: BMC Cancer 2021 21:687

    Content type: Research article

    Published on:

  11. Testicular Self-Examination (TSE) causes earlier diagnosis of Testicular cancer (TC). Hence, all men aged between15 to 35 years should perform TSE every month. This study aims to survey the effect of education...

    Authors: Ali Khani Jeihooni, Hanieh Jormand, Mehdi Ansari, Pooyan Afzali Harsini and Tayebeh Rakhshani

    Citation: BMC Cancer 2021 21:685

    Content type: Research

    Published on:

  13. Access to childhood cancer medicines is a critical global health challenge. There is a lack of sufficient context-specific data in Ghana on access to essential medicines for treating childhood cancers. Here, w...

    Authors: Kofi Boamah Mensah, Adwoa Bemah Boamah Mensah, Varsha Bangalee, Neelaveni Padayachee and Frasia Oosthuizen

    Citation: BMC Cancer 2021 21:683

    Content type: Research

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  14. We aimed to evaluate the effects of different therapeutic options to prevent the evolution of vaginal stenosis after pelvic radiotherapy in women with cervical cancer.

    Authors: Jumara Martins, Ana Francisca Vaz, Regina Celia Grion, Lúcia Costa-Paiva and Luiz Francisco Baccaro

    Citation: BMC Cancer 2021 21:682

    Content type: Research article

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  15. Prolactin receptor (PRLR) is an attractive antibody therapeutic target with expression across a broad population of breast cancers. Antibody efficacy, however, may be limited to subtypes with either PRLR overe...

    Authors: Mark G. Anderson, Qian Zhang, Luis E. Rodriguez, Claudie M. Hecquet, Cherrie K. Donawho, Peter J. Ansell and Edward B. Reilly

    Citation: BMC Cancer 2021 21:681

    Content type: Research article

    Published on:

  16. Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or p...

    Authors: Fang Yu, Babu Gajendran, Ning Wang, Klarke M. Sample, Wuling Liu, Chunlin Wang, Anling Hu, Eldad Zacksenhaus, Xiaojiang Hao and Yaacov Ben-David

    Citation: BMC Cancer 2021 21:680

    Content type: Research article

    Published on:

  20. Information about survival by stage in bladder cancer is scarce, as well as about survival of non-invasive bladder cancer. The aims of this study are: 1) to find out the distribution of bladder cancer by stage...

    Authors: J. Ripoll, M. Ramos, J. Montaño, J. Pons, A. Ameijide and P. Franch

    Citation: BMC Cancer 2021 21:676

    Content type: Research article

    Published on:

  21. The association between SOX14 and cancer has been reported. The aim of this study was to identify and validate the potential value of SOX14 methylation in the early detection of cervical cancer.

    Authors: Jing Zhao, Huiling Cao, Wenfan Zhang, Yongjuan Fan, Shujuan Shi and Rong Wang

    Citation: BMC Cancer 2021 21:675

    Content type: Research article

    Published on:

  22. Previous clinical trials have demonstrated the potential efficacy of rechallenge with anti- epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) for patients with RAS/BRAF V600E wild-type metastat...

    Authors: Hiromichi Nakajima, Daisuke Kotani, Hideaki Bando, Takeshi Kato, Eiji Oki, Eiji Shinozaki, Yu Sunakawa, Kentaro Yamazaki, Satoshi Yuki, Yoshiaki Nakamura, Takeharu Yamanaka, Takayuki Yoshino, Takashi Ohta, Hiroya Taniguchi and Yoshinori Kagawa

    Citation: BMC Cancer 2021 21:674

    Content type: Study protocol

    Published on:

  23. miRNAs and lncRNAs can regulate cellular biological processes both under physiological and pathological conditions including tumour initiation and progression. Interactions between differentially expressed div...

    Authors: Brigitta László, László Antal, Eszter Gyöngyösi, Anita Szalmás, Szilárd Póliska, György Veress and József Kónya

    Citation: BMC Cancer 2021 21:673

    Content type: Research article

    Published on:

  24. Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease that lack of effective therapeutic drugs. K-001 is an oral antitumor drug made from active ingredients of marine microorganisms. The current study ai...

    Authors: Jiujie Cui, Haiyan Yang, Jue Liu, Donghui Chen, Jiong Hu, Haiyan Zhang, Yu Wang, Ting Han, Tiebo Mao, Feng Jiao, Ewelina Biskup, Yaotian Pan, Min Liu and Liwei Wang

    Citation: BMC Cancer 2021 21:672

    Content type: Research article

    Published on:

  25. Integrated social care may help to mitigate social risk factors in order to achieve more equitable health outcomes. In cancer centers certified according to the criteria set out by the German Cancer Society, e...

    Authors: Clara Breidenbach, Simone Wesselmann, Nora Tabea Sibert, Olaf Ortmann, Katrin Blankenburg, Cindy Stoklossa, Gerhard Gebauer, Marina dos Santos Guilherme, Christoph Lindner, Susanne Peschel, Friedemann Schad, Paul Strecker, Lorenz Rieger, Julia Ferencz, Sebastian Dieng and Christoph Kowalski

    Citation: BMC Cancer 2021 21:671

    Content type: Research article

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  26. The second most common cancer among females in Bangladesh is cervical cancer. The national strategy for cervical cancer needs monitoring to ensure that patients have access to care. In order to provide accurat...

    Authors: Shagoofa Rakhshanda, Koustuv Dalal, Hasina Akhter Chowdhury, Cinderella Akbar Mayaboti, Progga Paromita, A. K. M. Fazlur Rahman, A. H. M. Eanayet Hussain and Saidur Rahman Mashreky

    Citation: BMC Cancer 2021 21:670

    Content type: Research article

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  28. Patients diagnosed with Barcelona Clinic Liver Cancer (BCLC) intermediate stage hepatocellular carcinoma (HCC) encompass a broad clinical population. Kinki criteria subclassifications have been proposed to bet...

    Authors: Masateru Yamamoto, Tsuyoshi Kobayashi, Masakazu Hashimoto, Shintaro Kuroda, Tomokazu Kawaoka, Hiroshi Aikata, Kazuaki Chayama and Hideki Ohdan

    Citation: BMC Cancer 2021 21:668

    Content type: Research

    Published on:

  29. Cervical cancer is one of the most common malignancies among women. Appropriate and timely treatment of these patients can reduce the complications and increase their survival. The objective of this study was ...

    Authors: Setareh Akhavan, Abbas Alibakhshi, Mahdieh Parsapoor, Abbas Alipour and Elahe Rezayof

    Citation: BMC Cancer 2021 21:667

    Content type: Research

    Published on:

  30. Early-stage non-small lung cancer patients may survive long enough to develop second primary lung cancers. However, few studies have accurately described the therapeutic method, evaluation or prognostic factor...

    Authors: Congcong Chen, Zixiang Wu, Ziheng Wu, Chuanqiang Wu, Qi Wang, Tianwei Zhan, Lingjun Dong, Shuai Fang and Ming Wu

    Citation: BMC Cancer 2021 21:666

    Content type: Research

    Published on:

  31. An important number of breast and ovarian cancer cases is due to a strong genetic predisposition. The main tool for identifying individuals at risk is recognizing a suggestive family history of cancer. We pres...

    Authors: Urska Kotnik, Borut Peterlin and Luca Lovrecic

    Citation: BMC Cancer 2021 21:665

    Content type: Research article

    Published on:

  32. Fenofibrate is a fibric acid derivative known to have a lipid-lowering effect. Although fenofibrate-induced peroxisome proliferator-activated receptor alpha (PPARα) transcription activation has been shown to p...

    Authors: Wei Zhu, Hongyang Zhao, Fenfen Xu, Bin Huang, Xiaojing Dai, Jikui Sun, Alphonce M. K. Nyalali, Kailiang Zhang and Shilei Ni

    Citation: BMC Cancer 2021 21:664

    Content type: Research

    Published on:

  34. Melanoma is a malignant cancer that affects melanocytes and is considered the most aggressive skin-type cancer. The prevalence for melanoma cancer for the last five year is about one million cases. The impact ...

    Authors: Mariana Nobre Farias de Franca, Raquel Geralda Isidório, João Henrique Oliveira Bonifacio, Edmilson Willian Propheta dos Santos, Jileno Ferreira Santos, Flaviano Melo Ottoni, Waldecy de Lucca Junior, Ricardo Scher, Ricardo José Alves and Cristiane Bani Corrêa

    Citation: BMC Cancer 2021 21:662

    Content type: Research

    Published on:

  35. To evaluate the effectiveness and safety of pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) in preventing neutropenia during chemoradiotherapy in patients with cervical cancer.

    Authors: Dongling Zou, Mingfang Guo and Qi Zhou

    Citation: BMC Cancer 2021 21:661

    Content type: Research article

    Published on:

  36. Head and Neck Cancer (HNC) survivors are at increased risk of developing a second primary cancer (SPC). Along with the environmental risk factors, genetic factors have been associated with a potential increase...

    Authors: Ilda Hoxhaj, Vladimir Vukovic, Stefania Boccia and Roberta Pastorino

    Citation: BMC Cancer 2021 21:660

    Content type: Research article

    Published on:

  37. In the phase III ALCYONE trial, daratumumab plus bortezomib/melphalan/prednisone (D-VMP) significantly improved overall response rate and progression-free status compared with VMP alone in transplant-ineligibl...

    Authors: Stefan Knop, Maria-Victoria Mateos, Meletios A. Dimopoulos, Kenshi Suzuki, Andrzej Jakubowiak, Chantal Doyen, Paulo Lucio, Zsolt Nagy, Ganna Usenko, Ludek Pour, Mark Cook, Sebastian Grosicki, Andre Crepaldi, Anna Marina Liberati, Philip Campbell, Tatiana Shelekhova…

    Citation: BMC Cancer 2021 21:659

    Content type: Research article

    Published on:

  38. The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy).

    Authors: Christer Borgfeldt, Erik Holmberg, Janusz Marcickiewicz, Karin Stålberg, Bengt Tholander, Elisabeth Åvall Lundqvist, Angelique Flöter-Rådestad, Maria Bjurberg, Pernilla Dahm-Kähler, Kristina Hellman, Elisabet Hjerpe, Preben Kjölhede, Per Rosenberg and Thomas Högberg

    Citation: BMC Cancer 2021 21:658

    Content type: Research article

    Published on:

  39. Long non-coding RNAs exert vital roles in several types of cancer. The objective of this study was to explore the role of LINC_00355 in gastric cancer (GC) progression and its potential mechanism.

    Authors: Jishui Zhang, Wenhao Lv, Yagang Liu, Weihua Fu, Baosheng Chen, Qiutong Ma and Xin Gao

    Citation: BMC Cancer 2021 21:657

    Content type: Research article

    Published on:

  40. Nutritional complications in patients with locally advanced head and neck cancer (LA-HNC) treated by concurrent chemoradiotherapy (CCRT) often lead to placement of a prophylactic gastrostomy (PG) tube, while i...

    Authors: Tatiana Dragan, Fréderic Duprez, André Van Gossum, Akos Gulyban, Sylvie Beauvois, Antoine Digonnet, Yassine Lalami and Dirk Van Gestel

    Citation: BMC Cancer 2021 21:656

    Content type: Research article

    Published on:

  41. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and circulating tumor cells (CTCs) have been associated with survival in castration-resistant prostate cancer (CRPC). However, no study h...

    Authors: Weelic Chong, Zhenchao Zhang, Rui Luo, Jian Gu, Jianqing Lin, Qiang Wei, Bingshan Li, Ronald Myers, Grace Lu-Yao, William Kevin Kelly, Chun Wang and Hushan Yang

    Citation: BMC Cancer 2021 21:655

    Content type: Research

    Published on:

  42. Updated response assessment in neuro-oncology (RANO) does not consider peritumoral non-enhancing lesion (NEL) and baseline (residual) contrast enhancement (CE) volume. The objective of this study is to explore...

    Authors: Hye Hyeon Moon, Ho Sung Kim, Ji Eun Park, Young-Hoon Kim and Jeong Hoon Kim

    Citation: BMC Cancer 2021 21:654

    Content type: Research

    Published on:

  43. Even though targeted therapies are available for cancers expressing oncogenic epidermal growth receptor (EGFR) and (or) human EGFR2 (HER2), acquired or intrinsic resistance often confounds therapy success. Com...

    Authors: Luis D. Borrero-García, Maria del Mar Maldonado, Julia Medina-Velázquez, Angel L. Troche-Torres, Luis Velazquez, Nilmary Grafals-Ruiz and Suranganie Dharmawardhane

    Citation: BMC Cancer 2021 21:652

    Content type: Research article

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  45. Advances in the early detection of cancer and its treatment have resulted in an increasing number of people living with and beyond breast cancer. Multimorbidity is also becoming more common in this population ...

    Authors: Murray Foster and Claire L. Niedzwiedz

    Citation: BMC Cancer 2021 21:650

    Content type: Research

    Published on:

  46. Clinical practice guidelines recommend active surveillance as the preferred treatment option for low-risk prostate cancer, but only a minority of eligible men receive active surveillance, and practice variatio...

    Authors: Shellie D. Ellis, Soohyun Hwang, Emily Morrow, Kim S. Kimminau, Kelly Goonan, Laurie Petty, Edward Ellerbeck and J. Brantley Thrasher

    Citation: BMC Cancer 2021 21:649

    Content type: Research article

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  48. In estrogen receptor (ER)-positive breast cancer (BC), young age is associated with poor prognosis. While very young patients respond better to chemotherapy, chemotherapy is less effective in ER-positive tumor...

    Authors: Joohyun Woo, Se Jeong Oh, Jeong-Yoon Song, Byung Joo Chae, Jung Eun Choi, Jeeyeon Lee, Heung Kyu Park and Woosung Lim

    Citation: BMC Cancer 2021 21:647

    Content type: Research article

    Published on:

  49. The tumour microenvironment (TME) not only plays a role during tumour progression and metastasis but also profoundly influences treatment efficacy. Environment-mediated drug resistance is a result of crosstalk...

    Authors: Xintong Lyu, Ping Wang, Qiao Qiao and Yuanjun Jiang

    Citation: BMC Cancer 2021 21:646

    Content type: Research article

    Published on:

  50. Breast cancer (BRCA) is a malignant tumor with high morbidity and mortality, which is a threat to women’s health worldwide. Ferroptosis is closely related to the occurrence and development of breast cancer. He...

    Authors: Ding Wang, Guodong Wei, Ju Ma, Shuai Cheng, Longyuan Jia, Xinyue Song, Ming Zhang, Mingyi Ju, Lin Wang, Lin Zhao and Shijie Xin

    Citation: BMC Cancer 2021 21:645

    Content type: Research article

    Published on:

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