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  1. Hematopoietic cell transplantation (HCT) is a curative option for a growing number of patients with hematologic diseases and malignancies. However, HCT-related factors, such as total body irradiation used for ...

    Authors: Saro H. Armenian, Lanie Lindenfeld, Aleksi Iukuridze, Meagan Echevarria, Samantha Bebel, Catherine Coleman, Ryotaro Nakamura, Farah Abdullah, Badri Modi, Kevin C. Oeffinger, Karen M. Emmons, Ashfaq A. Marghoob and Alan C. Geller

    Citation: BMC Cancer 2020 20:721

    Content type: Study protocol

    Published on:

  4. To observe the medium- and long-term clinical efficacy and safety of radioactive 125I seed implantation for refractory malignant tumours based on CT-guided 3D template-assisted technique.

    Authors: Guang Sheng Zhao, Song Liu, Liang Yang, Chuang Li, Ruo Yu Wang, Jun Zhou and Yue Wei Zhang

    Citation: BMC Cancer 2020 20:718

    Content type: Research article

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  5. Splenic marginal zone lymphoma (SMZL) is a rare lymphoid B-cell malignant neoplasm with primary involvement of the spleen. It is a chronic disease, of indolent behavior and prolonged survival. However, 25% of ...

    Authors: Luís Alberto de Pádua Covas Lage, Felipe Faganelli Caboclo dos Santos, Débora Levy, Frederico Rafael Moreira, Samuel Campanelli Freitas Couto, Hebert Fabrício Culler, Renata de Oliveira Costa, Vanderson Rocha and Juliana Pereira

    Citation: BMC Cancer 2020 20:717

    Content type: Research article

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  6. The value of chemotherapy in soft tissue sarcoma (STS) remains controversial. Several expert teams consider that chemotherapy provides a survival advantage and should be proposed in high-risk (HR) patients. Ho...

    Authors: Thomas Filleron, Sophie Le Guellec, Christine Chevreau, Bastien Cabarrou, Tom Lesluyes, Sabrina Lodin, Angélique Massoubre, Muriel Mounier, Muriel Poublanc, Frédéric Chibon and Thibaud Valentin

    Citation: BMC Cancer 2020 20:716

    Content type: Study protocol

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  7. Single rare cell characterization represents a new scientific front in personalized therapy. Imaging mass cytometry (IMC) may be able to address all these questions by combining the power of MS-CyTOF and micro...

    Authors: Izhar S. Batth, Qing Meng, Qi Wang, Keila E. Torres, Jared Burks, Jing Wang, Richard Gorlick and Shulin Li

    Citation: BMC Cancer 2020 20:715

    Content type: Research article

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  8. Diffuse large B-cell lymphoma (DLBCL) is a spectrum of disease comprising more than 30% of non-Hodgkin lymphomas. Although studies have identified several molecular subgroups, the heterogeneous genetic backgro...

    Authors: Wei Zhang, Li Yang, Yu’ Qi Guan, Ke’ Feng Shen, Mei’ Lan Zhang, Hao’ Dong Cai, Jia’ Chen Wang, Ying Wang, Liang Huang, Yang Cao, Na Wang, Xiao’ Hong Tan, Ken He Young, Min Xiao and Jian’ Feng Zhou

    Citation: BMC Cancer 2020 20:714

    Content type: Research article

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  9. Studies have shown that abnormal changes of specific-gene DNA methylation in leukocytes may be associated with an elevated risk of cancer. However, associations between the methylation of the zinc-related genes,

    Authors: Anqi Ge, Song Gao, Yupeng Liu, Hui Zhang, Xuan Wang, Lei Zhang, Da Pang and Yashuang Zhao

    Citation: BMC Cancer 2020 20:713

    Content type: Research article

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  10. Treatment with tumor-Infiltrating Lymphocytes (TIL) is an innovative therapy for advanced melanoma with promising clinical phase I/II study results and likely beneficial cost-effectiveness. As a randomized con...

    Authors: Melanie Lindenberg, Valesca Retèl, Maartje Rohaan, Joost van den Berg, John Haanen and Wim van Harten

    Citation: BMC Cancer 2020 20:712

    Content type: Research article

    Published on:

  11. Up to 75% of women diagnosed with breast cancer report chemotherapy-related cognitive changes (CRCC) during treatment, including decreased memory, attention, and processing speed. Though CRCC negatively impact...

    Authors: Jennifer Brunet, Meagan Barrett-Bernstein, Kendra Zadravec, Monica Taljaard, Nathalie LeVasseur, Amirrtha Srikanthan, Kelcey A. Bland, Barbara Collins, Julia W. Y. Kam, Todd C. Handy, Sherri Hayden, Christine Simmons, Andra M. Smith, Naznin Virji-Babul and Kristin L. Campbell

    Citation: BMC Cancer 2020 20:711

    Content type: Study protocol

    Published on:

  12. NSCLC patients with EGFR mutation were at a higher incidence of developing brain metastasis (BM). Patients with BM are associated with high mortality. Reducing BM incidence becomes increasingly significant for...

    Authors: Wen Ouyang, Jing Yu, Yan Zhou, Jing Hu, Zhao huang, Junhong Zhang and Conghua Xie

    Citation: BMC Cancer 2020 20:699

    Content type: Research article

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  13. The evidence that albumin-bound paclitaxel (nab-paclitaxel) is safe and efficacious for the treatment of many types of malignant tumors is continuously increasing. However, the evidence and clinical data of na...

    Authors: Zhichao Tian, Fan Zhang, Po Li, Jiaqiang Wang, Jinpo Yang, Peng Zhang, Weitao Yao and Xin Wang

    Citation: BMC Cancer 2020 20:698

    Content type: Research article

    Published on:

  14. The prognosis of glioblastoma remains poor, related to its diffuse spread within the brain. There is an ongoing search for molecular regulators of this particularly invasive behavior. One approach is to look f...

    Authors: Vanina D. Heuser, Aida Kiviniemi, Laura Lehtinen, Sune Munthe, Bjarne Winther Kristensen, Jussi P. Posti, Jussi O. T. Sipilä, Ville Vuorinen, Olli Carpén and Maria Gardberg

    Citation: BMC Cancer 2020 20:710

    Content type: Research article

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  15. It has previously been shown that bevacizumab, when added to chemotherapy, improved overall survival in several cancers. In glioblastoma multiforme (GBM), bevacizumab increased progression-free survival and it...

    Authors: Chiung-Chyi Shen, Wen-Yu Cheng, Chung-Hsin Lee, Xue-Jun Dai, Ming-Tsang Chiao, Yea-Jiuen Liang, Wan-Yu Hsieh, Tsuo-Fei Mao, Guo-Shi Lin, Shou-Ren Chen, Bai-Shuan Liu and Jun-Peng Chen

    Citation: BMC Cancer 2020 20:709

    Content type: Research article

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  16. Studying entire dietary patterns is a promising alternative approach to overcome limitations of the single food or nutrient approach. We evaluated the relationship between the scores of 4 established Dietary A...

    Authors: Zeinab Heidari, Elahe Mohammadi, Vahideh Aghamohammadi, Saba Jalali, Arezoo Rezazadeh, Fatemeh Sedaghat, Mojan Assadi and Bahram Rashidkhani

    Citation: BMC Cancer 2020 20:708

    Content type: Research article

    Published on:

  17. A number of studies have reported hyperprogressive disease (HPD) in non-small cell lung cancer (NSCLC) after treatment with immune checkpoint inhibitor (ICI). This study aimed to summarize the incidence and su...

    Authors: Yan Chen, Junjie Hu, Fangfang Bu, Haiping Zhang, Ke Fei and Peng Zhang

    Citation: BMC Cancer 2020 20:707

    Content type: Research article

    Published on:

  18. Cervical cancer is the second leading type of female cancer in Ethiopia. Screening for cervical cancer is primarily conducted using visual inspection with 5% acetic acid (VIA). Liquid-based cytology (LBC) is n...

    Authors: Getnet Tesfaw, Yesuf Ahmed, Lealem Gedefaw, Lamessa Dube, Samson Godu, Kirubel Eshetu, Mesfin Nigussie, Haftamu Hailekiros, Moses Joloba, Gelila Goba and Alemseged Abdissa

    Citation: BMC Cancer 2020 20:706

    Content type: Research article

    Published on:

  19. This study aimed to comprehensively investigate the effect of spread through air spaces (STAS) on clinicopathologic features, molecular characteristics, immunohistochemical expression, and prognosis in lung ad...

    Authors: Meng Jia, Shili Yu, Jiaqi Yu, Yuemin Li, Hongwen Gao and Ping-Li Sun

    Citation: BMC Cancer 2020 20:705

    Content type: Research article

    Published on:

  20. The insulin-like growth factor 1 receptor (IGF1R) is suspected to be involved in colorectal carcinogenesis and has been associated with worse survival in colorectal cancer (CRC). We hypothesized that the alleg...

    Authors: Steffen M. Heckl, Marie Pellinghaus, Hans-Michael Behrens, Sandra Krüger, Stefan Schreiber and Christoph Röcken

    Citation: BMC Cancer 2020 20:704

    Content type: Research article

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  21. Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the on...

    Authors: Andy Göbel, Valentina M. Zinna, Stefania Dell’Endice, Nikolai Jaschke, Jan Dominik Kuhlmann, Pauline Wimberger and Tilman D. Rachner

    Citation: BMC Cancer 2020 20:703

    Content type: Research article

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  22. Craniospinal irradiation (CSI) of childhood tumors with the RapidArc technique is a new method of treatment. Our objective was to compare the acute hematological toxicity pattern during 3D conformal radiothera...

    Authors: Zoltán Lőcsei, Róbert Farkas, Kornélia Borbásné Farkas, Klára Sebestyén, Zsolt Sebestyén, Zoltán Musch, Ágnes Vojcek, Noémi Benedek, László Mangel and Gábor Ottóffy

    Citation: BMC Cancer 2020 20:702

    Content type: Research article

    Published on:

  23. For loco-regionally advanced, but transorally resectable oropharyngeal cancer (OPSCC), the current standard of care includes surgical resection and risk-adapted adjuvant (chemo) radiotherapy, or definite chemo...

    Authors: Lara Bußmann, Simon Laban, Claus Wittekindt, Carmen Stromberger, Silke Tribius, Nikolaus Möckelmann, Arne Böttcher, Christian Stephan Betz, Jens Peter Klussmann, Volker Budach, Adrian Muenscher and Chia-Jung Busch

    Citation: BMC Cancer 2020 20:701

    Content type: Study protocol

    Published on:

  24. Advanced stage operable cancers of larynx are treated with total laryngectomy including thyroid resection in most of the cases, which may expose patient to hypothyroidism and hypoparathyroidism. The requiremen...

    Authors: Surendra Singh Baghel, Pawan Singhal, Namita Verma, Ritu Sehra, Rajeev Yadav, Sunita Agarwal, Man Prakash Sharma and D. P. Gupta

    Citation: BMC Cancer 2020 20:700

    Content type: Research article

    Published on:

  25. The end of active treatment is a period of high stress for young people with cancer, but limited literature exists about their information and support needs during this phase. This study aimed to understand th...

    Authors: Sarah Lea, Ana Martins, Lorna A. Fern, Matthew Bassett, Maria Cable, Gary Doig, Sue Morgan, Louise Soanes, Michael Whelan and Rachel M. Taylor

    Citation: BMC Cancer 2020 20:697

    Content type: Research article

    Published on:

  26. Between 30 and 50% of colon tumors have mutations in the Kirsten-ras (KRAS) gene, which have a large nutritional attributable risk. Despite its high frequency in colorectal cancer (CRC), data to support specific ...

    Authors: Achraf El Asri, Btissame Zarrouq, Khaoula El Kinany, Laila Bouguenouch, Karim Ouldim and Karima El Rhazi

    Citation: BMC Cancer 2020 20:696

    Content type: Review

    Published on:

  27. The International Agency for Research on Cancer classified radon and its decay-products as Group-1-human-carcinogens, and with the current knowledge they are linked specifically to lung cancer. Biokinetic mode...

    Authors: Cheng Peng, Natalie DuPre, Trang VoPham, Yujing J. Heng, Gabrielle M. Baker, Christopher A. Rubadue, Kimberly Glass, Abhijeet Sonawane, Oana Zeleznik, Peter Kraft, Susan E. Hankinson, A. Heather Eliassen, Jaime E. Hart, Francine Laden and Rulla M. Tamimi

    Citation: BMC Cancer 2020 20:695

    Content type: Research article

    Published on:

  28. Early diagnosis and continuous monitoring are necessary for an efficient management of cervical cancers (CC). Liquid biopsy, such as detecting circulating tumor DNA (ctDNA) from blood, is a simple, non-invasiv...

    Authors: Sun-Young Lee, Dong-Kyu Chae, Sung-Hun Lee, Yohan Lim, Jahyun An, Chang Hoon Chae, Byung Chul Kim, Jong Bhak, Dan Bolser and Dong-Hyu Cho

    Citation: BMC Cancer 2020 20:694

    Content type: Research article

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  29. To identify modifiable risk factors that contribute to cancer holds important public health relevance for setting up prevention strategies. Therefore, the aim of this study was to estimate the proportion of ca...

    Authors: Leandro F. M. Rezende, Eliana Murata, Beatriz Giannichi, Luciana Yuki Tomita, Gabriela Arantes Wagner, Zila M. Sanchez, Carlos Celis-Morales and Gerson Ferrari

    Citation: BMC Cancer 2020 20:693

    Content type: Research article

    Published on:

  30. Differential DNA methylation panel derived from peripheral blood could serve as biomarkers of CRC susceptibility. However, most of the previous studies utilized post-diagnostic blood DNA which may be markers o...

    Authors: Justina Ucheojor Onwuka, Dapeng Li, Yupeng Liu, Hao Huang, Jing Xu, Ying Liu, Yuanyuan Zhang and Yashuang Zhao

    Citation: BMC Cancer 2020 20:692

    Content type: Research article

    Published on:

  31. Previous studies have shown that fibrinogen-to-albumin ratio (FAR) is a novel prognostic immune biomarker in various diseases. In this study, we investigated the role of FAR in the prognosis of patients with s...

    Authors: Qiang An, Wei Liu, Yujia Yang and Bing Yang

    Citation: BMC Cancer 2020 20:691

    Content type: Research article

    Published on:

  32. This study profiled the somatic genes mutations and the copy number variations (CNVs) in cerebrospinal fluid (CSF)-circulating tumor DNA (ctDNA) from patients with neoplastic meningitis (NM).

    Authors: Yue Zhao, Jun Ying He, Jun Zhao Cui, Zi-Qi Meng, Yue Li Zou, Xiao Su Guo, Xin Chen, Xueliang Wang, Li-Tian Yan, Wei Xin Han, Chunyan Li, Li Guo and Hui Bu

    Citation: BMC Cancer 2020 20:690

    Content type: Research article

    Published on:

  34. Although surgery is the definitive curative treatment for biliary tract cancer (BTC), outcomes after surgery alone have not been satisfactory. Adjuvant therapy with S-1 may improve survival in patients with BT...

    Authors: Osamu Itano, Yusuke Takemura, Norihiro Kishida, Eiji Tamagawa, Hiroharu Shinozaki, Ken Ikeda, Hidejiro Urakami, Shigenori Ei, Shigeo Hayatsu, Keiichi Suzuki, Tadayuki Sakuragawa, Masatsugu Ishii, Masaya Shito, Koichi Aiura, Hiroto Fujisaki, Kiminori Takano…

    Citation: BMC Cancer 2020 20:688

    Content type: Research article

    Published on:

  35. First-line treatment with FOLFOXIRI plus bevacizumab (BEV) is highly effective and regarded as one of the standards-of-care for patients with metastatic colorectal cancer (mCRC), despite the high incidence of ...

    Authors: Masaaki Miyo, Takeshi Kato, Takayuki Yoshino, Takeharu Yamanaka, Hideaki Bando, Hironaga Satake, Kentaro Yamazaki, Hiroya Taniguchi, Eiji Oki, Masahito Kotaka, Koji Oba, Yoshinori Miyata, Kei Muro, Yoshito Komatsu, Hideo Baba and Akihito Tsuji

    Citation: BMC Cancer 2020 20:687

    Content type: Study protocol

    Published on:

  36. In this study, we examined the differential associations of various proinflammatory and anti-inflammatory cytokines with depression severity from the development of breast cancer to subsequent chemotherapy tre...

    Authors: Bor-Show Tzang, Vincent Chin-Hung Chen, Ching-Chuan Hsieh, Wen-Ke Wang, Yi-Ping Weng, Hsing-Ying Ho, Ya-Ting Hsu, Han-Pin Hsaio, Jun-Cheng Weng and Yi-Lung Chen

    Citation: BMC Cancer 2020 20:686

    Content type: Research article

    Published on:

  37. Colorectal cancer (CRC) is a heterogeneous tumor having various genetic alterations. The current treatment options had limited impact on disease free survival due to therapeutic resistance. Novel anticancer ag...

    Authors: Khayal Al-Khayal, Mansoor-Ali Vaali-Mohammed, Mohammed Elwatidy, Thamer Bin Traiki, Omar Al-Obeed, Mohammad Azam, Zahid Khan, Maha Abdulla and Rehan Ahmad

    Citation: BMC Cancer 2020 20:685

    Content type: Research article

    Published on:

  38. Nivolumab has changed the treatment of advanced gastric cancer (AGC). Nivolumab shows better outcomes compared to best supportive care among AGC patients who received at least two prior regimens. However, ther...

    Authors: Toshihiko Matsumoto, Yosuke Yamamoto, Yusuke Kuriona, Ukyo Okazaki, Shogo Kimura, Kou Miura, Takao Tsuduki, Takanori Watanabe, Yusuke Mastumoto and Masahiro Takatani

    Citation: BMC Cancer 2020 20:684

    Content type: Research article

    Published on:

  39. Immune checkpoint inhibitors (ICIs) reported remarkable achievements in several solid tumours. However, in metastatic colorectal cancer (mCRC) promising results are limited to patients with deficient mismatch ...

    Authors: Carlotta Antoniotti, Beatrice Borelli, Daniele Rossini, Filippo Pietrantonio, Federica Morano, Lisa Salvatore, Sara Lonardi, Federica Marmorino, Stefano Tamberi, Salvatore Corallo, Giampaolo Tortora, Francesca Bergamo, Di Stefano Brunella, Alessandra Boccaccino, Elisa Grassi, Patrizia Racca…

    Citation: BMC Cancer 2020 20:683

    Content type: Study protocol

    Published on:

  40. Long intergenic non-coding RNA 00511 (LINC00511) is highly expressed in diverse cancers and has a correlation with poor clinical outcomes for cancer patients. In view of contradictory data among published data...

    Authors: Yannick Luther Agbana, Manzama-Esso Abi, Yueli Ni, Guohang Xiong, Jing Chen, Fang Yun, Zihan Yi, Qiao Zhang, Zhe Yang, Yingmin Kuang and Yuechun Zhu

    Citation: BMC Cancer 2020 20:682

    Content type: Research article

    Published on:

  41. Iron is required for cellular metabolism, and rapidly proliferating cancer cells require more of this essential nutrient. Therefore, iron regulation may well represent a new avenue for cancer therapy. We have ...

    Authors: Shogo Amano, Seiji Kaino, Shuhei Shinoda, Hirofumi Harima, Toshihiko Matsumoto, Koichi Fujisawa, Taro Takami, Naoki Yamamoto, Takahiro Yamasaki and Isao Sakaida

    Citation: BMC Cancer 2020 20:681

    Content type: Research article

    Published on:

  42. There is international interest in risk-stratification of breast screening programmes to allow women at higher risk to benefit from more frequent screening and chemoprevention. Risk-stratification also identif...

    Authors: Lorna McWilliams, Victoria G. Woof, Louise S. Donnelly, Anthony Howell, D. Gareth Evans and David P. French

    Citation: BMC Cancer 2020 20:680

    Content type: Research article

    Published on:

  43. The incidence of anal squamous cell carcinoma (SCC) has been steadily growing globally in the past decade. Clinical data on anal SCC from China are rare. We conducted this study to describe the clinical and ep...

    Authors: Yong Lu, Xiaohao Wang, Peiyang Li, Tao Zhang, Jiaming Zhou, Yufeng Ren, Yi Ding, Haihua Peng, Qichun Wei, Kaiyun You, Jason J. Ong, Christopher K. Fairley, Andrew E. Grulich, Meijin Huang, Yuanhong Gao and Huachun Zou

    Citation: BMC Cancer 2020 20:679

    Content type: Research article

    Published on:

  45. For patients with mid and distal rectal cancer, robust evidence on long-term outcome and causal treatment effects of transanal total mesorectal excision (TaTME) is lacking. This multicentre retrospective cohor...

    Authors: F. B. de Lacy, S. X. Roodbeen, J. Ríos, J. van Laarhoven, A. Otero-Piñeiro, R. Bravo, T. Visser, R. van Poppel, S. Valverde, R. Hompes, C. Sietses, A. Castells, W. A. Bemelman, P. J. Tanis and A. M. Lacy

    Citation: BMC Cancer 2020 20:677

    Content type: Research article

    Published on:

  46. Estrogen receptor (ER) positive breast cancer is often effectively treated with drugs that inhibit ER signaling, i.e., tamoxifen (TAM) and aromatase inhibitors (AIs). However, 30% of ER+ breast cancer patients...

    Authors: Maryam Soleimani Dodaran, Simone Borgoni, Emre Sofyalı, Pernette J. Verschure, Stefan Wiemann, Perry D. Moerland and Antoine H. C. van Kampen

    Citation: BMC Cancer 2020 20:676

    Content type: Research article

    Published on:

  47. Breast cancer clinical management requires the assessment of hormone receptors (estrogen (ER) and progesterone receptor (PR)), human epidermal growth factor receptor 2 (HER2) and cellular proliferation index K...

    Authors: Laura Rey-Vargas, Juan Carlos Mejía-Henao, María Carolina Sanabria-Salas and Silvia J. Serrano-Gomez

    Citation: BMC Cancer 2020 20:675

    Content type: Research article

    Published on:

  50. Lymph node metastasis in the cervical region posterior to level V (PLV) can occurs in patients with nasopharyngeal carcinoma (NPC), but the significance of lymph node metastasis in this region and the delineat...

    Authors: Chaoyang Jiang, Hui Gao, Ling Zhang, Hua Li, Tao Zhang, Ji Ma and Bisheng Liu

    Citation: BMC Cancer 2020 20:667

    Content type: Research article

    Published on:

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