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  1. Osteosarcoma is the most common primary malignant bone tumor. The current study was conducted to describe the general condition of patients with primary osteosarcoma in a single cancer center in Tianjin, China...

    Authors: Chao Zhang, Haixiao Wu, Guijun Xu, Yao Xu, Wenjuan Ma, Zhijun Li and Jin Zhang
    Citation: BMC Cancer 2023 23:506
    Content type: Research Published on:

  2. The systemic inflammation score (SIS), based on serum albumin (Alb) and lymphocyte-to-monocyte ratio (LMR), is a novel prognostic tool for some tumours. Studies indicate that the SIS can be used as a postopera...

    Authors: Chunyue Huang, Mengyao Wang, Liwen Chen, Hongmei Wang, Donglan Huang, Jianjun Shi, Weijun Zhang, Yunhong Tian and Yujia Zhu
    Citation: BMC Cancer 2023 23:505
    Content type: Research Published on:

  3. Molecular subtypes predict prognosis in muscle-invasive bladder cancer (MIBC) and are explored as predictive markers. To provide a common base for molecular subtyping and facilitate clinical applications, a co...

    Authors: Florestan J. Koll, Claudia Döring, Csilla Olah, Tibor Szarvas, Jens Köllermann, Benedikt Hoeh, Felix K.-H. Chun, Henning Reis and Peter J. Wild
    Citation: BMC Cancer 2023 23:504
    Content type: Research Published on:

  7. Decisions to participate in cancer trials are associated with uncertainty, distress, wanting to help find a cure, the hope for benefit, and altruism. There is a gap in the literature regarding research examini...

    Authors: Lynn Corcoran, Christine M. Friedenreich, Margaret L. McNeely, Nicole S. Culos-Reed, Gordon Bell, Leanne Dickau, Kerry S. Courneya and Jeff K. Vallance
    Citation: BMC Cancer 2023 23:500
    Content type: Research Published on:

  8. Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and is notorious for its resistance to both chemotherapy and small-molecule inhibitor targeted therapies. Subcellular targeted c...

    Authors: Stefan Mrdenovic, Yanping Wang, Lijuan Yin, Gina Chia-Yi Chu, Yan Ou, Michael S. Lewis, Marija Heffer, Edwin M. Posadas, Haiyen E. Zhau, Leland W. K. Chung, Mouad Edderkaoui, Stephen J. Pandol, Ruoxiang Wang and Yi Zhang
    Citation: BMC Cancer 2023 23:499
    Content type: Research Published on:

  9. The frailty index (FI) is one way in which frailty can be quantified. While it is measured as a continuous variable, various cut-off points have been used to categorise older adults as frail or non-frail, and ...

    Authors: James A. Fletcher, Benignus Logan, Natasha Reid, Emily H. Gordon, Rahul Ladwa and Ruth E. Hubbard
    Citation: BMC Cancer 2023 23:498
    Content type: Research Published on:

  10. Cancer’s hallmark feature is its ability to evolve, leading to metastasis and recurrence. Although genetic mutations and epigenetic changes have been implicated, they don’t fully explain the leukocytic traits ...

    Authors: Mengtao Li, John R. Basile, Sanjay Mallya and Yi-Ling Lin
    Citation: BMC Cancer 2023 23:497
    Content type: Research Published on:

  11. Numerous studies have demonstrated that the high-order features (HOFs) of blood test data can be used to predict the prognosis of patients with different types of cancer. Although the majority of blood HOFs ca...

    Authors: Liping Luo, Yubo Tan, Shixuan Zhao, Man Yang, Yurou Che, Kezhen Li, Jieke Liu, Huaichao Luo, Wenjun Jiang, Yongjie Li and Weidong Wang
    Citation: BMC Cancer 2023 23:496
    Content type: Research Published on:

  12. Breast malignancies are now the most common and deadliest type of neoplasms among women worldwide. Novel therapeutic approaches are needed to combat advanced stages of breast cancer. In this study, we aimed to...

    Authors: Mohammadhossein Pournabee, Mahsa Keshavarz-Fathi, Pooyesh Esmaeili, Pouya Mahdavi Sharif, Fatemeh Nili and Behnaz Jahanbin
    Citation: BMC Cancer 2023 23:495
    Content type: Research Published on:

  13. Neuropeptide Y (NPY) is an abundant neurohormone in human breast carcinomas that acts on a class of G-protein coupled receptors, of which NPY1R and NPY5R are the most highly expressed. This abundance is exploi...

    Authors: Sydney A. Pascetta, Sarah M. Kirsh, Makenna Cameron and James Uniacke
    Citation: BMC Cancer 2023 23:494
    Content type: Research Published on:

  14. Over the past decade, therapeutic options in head and neck supraglottic squamous cell carcinoma have constantly evolved. The classical total laryngectomy has been partially replaced by alternative organ- and f...

    Authors: S. Hassid, B. Krug, S. Deheneffe, J-F. Daisne, G. Delahaut, G. Lawson, R. Crott and S. Van der Vorst
    Citation: BMC Cancer 2023 23:493
    Content type: Study Protocol Published on:

  16. Metabolic reprogramming is one of hallmarks of cancer progression and is of great importance for the tumor microenvironment (TME). As an abundant metabolite, lactate has been found to play a critical role in c...

    Authors: Rui Shi, Haojia Li, Sitian Wei, Zhicheng Yu, Jun Zhang, Qi Zhang, Ting Zhou, Yuwei Yao, Qian Zhang, Tangansu Zhang and Hongbo Wang
    Citation: BMC Cancer 2023 23:491
    Content type: Research Published on:

  17. Thrombocytopenia is a common complication in cancer patients undergoing chemotherapy. Chemotherapy-induced thrombocytopenia (CIT) leads to dose reduction and treatment delays, lowering chemotherapy efficacy an...

    Authors: Jiwon Shin, Min-Jung Kim, Xingguo Quan, Ji Woong Kim, Sukmook Lee, SaeGwang Park, Jee-Yeong Jeong and Kyungmoo Yea
    Citation: BMC Cancer 2023 23:490
    Content type: Research Published on:

  19. Single-cell RNA-seq has emerged as an innovative technology used to study complex tissues and characterize cell types, states, and lineages at a single-cell level. Classification of bulk tumors by their indivi...

    Authors: Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Robert W. Porter, Sandhya Krishnan, Jyothishmathi Swaminathan, Amber Gibson, Alexander J. Lazar, J. Andrew Livingston, Vidya Gopalakrishnan, Nancy Gordon, Najat C. Daw, Nicholas E. Navin, Richard Gorlick and Joseph A. Ludwig
    Citation: BMC Cancer 2023 23:488
    Content type: Research article Published on:

  20. Organoids are a three-dimensional (3D) culture system that simulate actual organs. Therefore, tumor organoids are expected to predict precise response to chemotherapy in patients. However, to date, few studies...

    Authors: Fumiya Ito, Katsuhiro Kato, Izumi Yanatori, Yuki Maeda, Toyoaki Murohara and Shinya Toyokuni
    Citation: BMC Cancer 2023 23:487
    Content type: Research Published on:

  21. Thermal therapy induces an immune response in patients with hepatocellular carcinoma (HCC), but the dynamic characteristics of the natural killer (NK) cell immune response post-thermal ablation remain unclear....

    Authors: Hai-Yan Wang, Xiong-Wei Cui, Yong-Hong Zhang, Yu Chen, Ning-Ning Lu, Li Bai and Zhong-Ping Duan
    Citation: BMC Cancer 2023 23:486
    Content type: Research Published on:

  22. Most traditional procedures can destroy tissue natural structure, and the information on spatial distribution and temporal distribution of immune milieu in situ would be lost. We aimed to explore the potential...

    Authors: Jiangchun Wu, Qinhao Guo, Jun Zhu, Yong Wu, Simin Wang, Siyuan Liang, Xingzhu Ju and Xiaohua Wu
    Citation: BMC Cancer 2023 23:485
    Content type: Research Published on:

  23. Altered cellular metabolism has long been recognized as a hallmark of cancer. Oncogenic signaling cascades induce metabolic rewiring that further supports tumorigenesis, therapy resistance and metastasis. In v...

    Authors: Marija Trajkovic-Arsic and Elavarasan Subramani
    Citation: BMC Cancer 2023 23:484
    Content type: Editorial Published on:

  24. The authors intend to compare the effects of each targeted therapy (TT) in the treatment of patients with metastatic renal cell carcinoma (mRCC) using big data based on the Korean National Health Insurance Sys...

    Authors: Dong Hyuk Kang, Joo Yong Lee, Yunhee Lee and U-Syn Ha
    Citation: BMC Cancer 2023 23:483
    Content type: Research Published on:

  25. We aimed to examine whether patients with de novo and relapsed/progressed stage IIIB–IV non-small cell lung cancer (NSCLC) without epidermal growth factor receptor (EGFR) or anaplastic lymphoma kinase (ALK) mutat...

    Authors: Byeong-Chan Oh, Ae-Ryeo Cho, Jin Hyun Nam, So-Young Yang, Min Ji Kim, Sun-Hong Kwon and Eui-Kyung Lee
    Citation: BMC Cancer 2023 23:482
    Content type: Research Published on:

  26. This study aims to evaluate the clinical efficacy and side effects of setting up a high-risk clinical target volume (CTV-hr) alongside simultaneous integrated boost intensity-modulated radiotherapy (IMRT-SIB) ...

    Authors: Yuqi Jiang, Jing Wang, Peng Jiang, Xiang Wang, Lei Zhang and Yongchun Zhang
    Citation: BMC Cancer 2023 23:481
    Content type: Research Published on:

  27. The role of ATF2 in colon cancer (CC) is controversial. Recently, we reported that low ATF2 expression is characteristic of highly invasive tumors, suggesting that ATF2 might also be involved in therapy resist...

    Authors: Hao Yang, Kerstin Huebner, Chuanpit Hampel, Katharina Erlenbach-Wuensch, Selva Babu Selvamani, Vikas Shukla, Carol I. Geppert, Arndt Hartmann, Vijayalakshmi Mahadevan and Regine Schneider-Stock
    Citation: BMC Cancer 2023 23:480
    Content type: Research Published on:

  28. B-cell lymphoma 2 (Bcl-2) family proteins are key regulators of apoptosis, which possess four conserved Bcl-2 homologies (BH) domains. Among the BH domains, the BH3 domain is considered as a potent ‘death doma...

    Authors: Yihua Lin, Yiling Zhao, Minggui Chen, Zishuo Li, Qiao Liu, Jian Chen, Yi Ding, Chunyong Ding, Ye Ding, Cuiling Qi, Lingyun Zheng, Jiangchao Li, Rongxin Zhang, Jia Zhou, Lijing Wang and Qian-Qian Zhang
    Citation: BMC Cancer 2023 23:479
    Content type: Research Published on:

  29. ADP-ribosylation factor-like protein 4 C (ARL4C) is a member of the ARF small GTP-binding protein subfamily. The ARL4C gene is highly expressed in colorectal cancer (CRC). ARL4C protein promotes cell motility, in...

    Authors: Ryo Kanai, Takeshi Uehara, Takahiro Yoshizawa, Masato Kamakura, Tomoyuki Nakajima, Yasuhiro Kinugawa, Mai Iwaya, Shiho Asaka, Masato Kitazawa, Tadanobu Nagaya and Hiroyoshi Ota
    Citation: BMC Cancer 2023 23:478
    Content type: Research Published on:

  30. To investigate the value of CT radiomics features of meso-esophageal fat in the overall survival (OS) prediction of patients with locally advanced esophageal squamous cell carcinoma (ESCC).

    Authors: Shuo Yan, Fei-Ping Li, Lian Jian, Hai-Tao Zhu, Bo Zhao, Xiao-Ting Li, Yan-Jie Shi and Ying-Shi Sun
    Citation: BMC Cancer 2023 23:477
    Content type: Research Published on:

  32. Circulating tumor cells (CTCs) are important biological indicators of the lung cancer prognosis, and CTC counting and typing may provide helpful biological information for the diagnosis and treatment of lung c...

    Authors: Ying Xu, Xue Ren, Tong Jiang, Shuang Lv, Kuanke Gao, Yunen Liu and Ying Yan
    Citation: BMC Cancer 2023 23:475
    Content type: Research Published on:

  33. Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death, worldwide. The predominant causative factor for HCC is hepatitis B virus (HBV) infection. We conducted a meta-analysis to esti...

    Authors: Danxue Huang, Liyuan Ke, Hongxia Cui and Su Li
    Citation: BMC Cancer 2023 23:474
    Content type: Research Published on:

  34. The contributive role of the microbiome in tumor progression has been reported in multiple studies, such as the Fusobacterium nucleatum (F. nucleatum) in breast cancer (BC). This study aimed to explore the role o...

    Authors: Guiqiu Li, Yan Sun, Yu Huang, Jie Lian, Shaoyuan Wu, Dixian Luo and Hui Gong
    Citation: BMC Cancer 2023 23:473
    Content type: Research Published on:

  35. Cervical cancer is the fourth most frequently diagnosed and found to be the leading cause of cancer death in women, especially in low and middle-income countries. Even though cervical cancer is a preventable d...

    Authors: Alemayehu Sayih Belay, Wondwossen Niguse Asmare and Aychew Kassie
    Citation: BMC Cancer 2023 23:472
    Content type: Research Published on:

  36. Aprepitant, as a neurokinin-1 receptor (NK-1R) antagonist, originally applied for curing chemotherapy-induced nausea and vomiting, has been reported to have significant antitumor effect on several malignant tu...

    Authors: Xueyan Cao, Yang Yang, Wei Zhou, Yue Wang, Xue Wang, Xianxiu Ge, Fei Wang, Fangfang Zhou, Xueting Deng and Lin Miao
    Citation: BMC Cancer 2023 23:471
    Content type: Research Published on:

  37. The prognosis of patients with advanced biliary tract cancer (BTC) who have progressed on gemcitabine plus cisplatin is dismal. Trifluridine/tipiracil (FTD/TPI) and irinotecan have proven efficacy in different...

    Authors: Linde Kehmann, Marie-Luise Berres, Maria Gonzalez-Carmona, Dominik P. Modest, Raphael Mohr, Alexander Wree, Marino Venerito, Christian Strassburg, Verena Keitel, Christian Trautwein, Tom Luedde and Christoph Roderburg
    Citation: BMC Cancer 2023 23:470
    Content type: Study protocol Published on:

  38. Delay in the diagnosis of childhood cancer is one of the major health problem that contribute to decreased survival rates of children particularly in developing nations. Despite advances in the field of pediat...

    Authors: Yimenu Gardie, Mulugeta Wassie, Seid Wodajo, Mastewal Giza, Mulugeta Ayalew, Yihenew Sewale, Zelalem Feleke and Melkamu Tilahun Dessie
    Citation: BMC Cancer 2023 23:469
    Content type: Research Published on:

  39. Breast cancer brain metastasis (BCBM) is a growing therapeutic challenge and clinical concern. Stromal cancer-associated fibroblasts (CAFs) are crucial factors in the modulation of tumorigeneses and metastases...

    Authors: Md Rashedunnabi Akanda, Eun-Jung Ahn, Yeong Jin Kim, S M Abdus Salam, Myung-Giun Noh, Tae-Kyu Lee, Sung Sun Kim, Kyung-Hwa Lee and Kyung-Sub Moon
    Citation: BMC Cancer 2023 23:468
    Content type: Research Published on:

  40. Neoadjuvant chemoradiotherapy (NCRT) and total mesorectal excision are standard treatment regimen for patients with locally advanced rectal cancer (LARC). This sphincter-saving treatment strategy may be accomp...

    Authors: Jie Shi, Yi-Kan Cheng, Fang He, Jian Zheng, Yun-Long Wang, Xiang-Bo Wan, Hong-Cheng Lin and Xin-Juan Fan
    Citation: BMC Cancer 2023 23:467
    Content type: Study Protocol Published on:

  41. This study presents the trends of age-standardised incidence and mortality rates of common cancers in Brunei Darussalam from 2011 to 2020. All cancer cases diagnosed among Brunei Darussalam citizens and perman...

    Authors: Elvynna Leong, Sok King Ong, Khairil Azhar Si-Ramlee and Lin Naing
    Citation: BMC Cancer 2023 23:466
    Content type: Research Published on:

  42. To understand the proportion of uHCC (unresectable hepatocellular carcinoma) patients who achieve successful conversion resection in a high-volume setting with state of the art treatment options.

    Authors: Bo Zhang, Xuetao Shi, Kai Cui, Zhongchao Li, Lei Li, Zhaogang Liu, Chengsheng Zhang, Pengfei Sun, Jingtao Zhong, Zhicheng Sun, Zhibin Chang, Zhao Ma, Alex Gordon-Weeks, Mingming Li and Lei Zhao
    Citation: BMC Cancer 2023 23:465
    Content type: Research Published on:

  44. Treatment options for pretreated triple-negative breast cancer (TNBC) are limited. This study aimed to evaluate the efficacy and safety of apatinib, an antiangiogenic agent, in combination of etoposide for pre...

    Authors: Mengru Cao, Hailing Lu, Shi Yan, Hui Pang, Lichun Sun, Chunhong Li, Xuesong Chen, Wei Liu, Jing Hu, Jian Huang, Ying Xing, Ningzhi Zhang, Yingqi Chen, Ting He, Danni Zhao, Yuanyuan Sun…
    Citation: BMC Cancer 2023 23:463
    Content type: Research Published on:

  47. Double reading (DR) in screening mammography increases cancer detection and lowers recall rates, but has sustainability challenges due to workforce shortages. Artificial intelligence (AI) as an independent rea...

    Authors: Nisha Sharma, Annie Y. Ng, Jonathan J. James, Galvin Khara, Éva Ambrózay, Christopher C. Austin, Gábor Forrai, Georgia Fox, Ben Glocker, Andreas Heindl, Edit Karpati, Tobias M. Rijken, Vignesh Venkataraman, Joseph E. Yearsley and Peter D. Kecskemethy
    Citation: BMC Cancer 2023 23:460
    Content type: Research Published on:

  48. Triple negative BCa (TNBC) is defined by a lack of expression of estrogen (ERα), progesterone (PgR) receptors and human epidermal growth factor receptor 2 (HER2) as assessed by protein expression and/or gene a...

    Authors: Elena A. Takano, Melissa M. Younes, Katie Meehan, Lisa Spalding, Max Yan, Prue Allan, Stephen B. Fox, Andy Redfern, David Clouston, Graham G. Giles, Elizabeth L. Christie, Robin L. Anderson, Magnus Zethoven, Kelly-Anne Phillips, Kylie Gorringe and Kara L. Britt
    Citation: BMC Cancer 2023 23:459
    Content type: Research Published on:

  49. Pembrolizumab has become an integral first line therapeutic agent for non-small cell lung cancer (NSCLC), but its potential predictive role in clinical and molecular characteristics remains to be clarified. Ac...

    Authors: Wenjie Liu, Gengwei Huo and Peng Chen
    Citation: BMC Cancer 2023 23:458
    Content type: Research Published on:

  50. Smoking, alcohol consumption, and human papillomavirus (HPV) infection are known risk factors for oral squamous cell carcinoma (OSCC) including SCC of oropharynx (SCCOP) and SCC of oral cavity (SCCOC). Researc...

    Authors: Zheng Yang, Peng Sun, Kristina R. Dahlstrom, Neil Gross and Guojun Li
    Citation: BMC Cancer 2023 23:457
    Content type: Research Published on:

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