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  1. Calcium-activated nucleotidase 1 (CANT1), functions as a calcium-dependent nucleotidase with a preference for UDP. However, the potential clinical value of CANT1 in lung adenocarcinoma (LA) has not been fully ...

    Authors: Qiwei Yao, Yilin Yu, Zhiping Wang, Mengyan Zhang, Jiayu Ma, Yahua Wu, Qunhao Zheng and Jiancheng Li

    Citation: BMC Cancer 2022 22:117

    Content type: Research

    Published on:

  2. Sodium glucose transporters (SGLTs) play vital roles in glucose uptake in many solid cancers, including pancreatic cancer (PC). However, their expression profile in pancreatic cancer and correlation with progn...

    Authors: Jiali Du, Jichun Gu, Junyuan Deng, Lei Kong, Yujie Guo, Chen Jin, Yun Bao, Deliang Fu and Ji Li

    Citation: BMC Cancer 2022 22:116

    Content type: Research

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  3. To identify hub genes from the competing endogenous RNA (ceRNA) network of lung adenocarcinoma (LUAD) and to explore their potential functions on prognosis of patients from a single-cell perspective.

    Authors: Wenhan Chen, Zhifeng Guo, Jingyang Wu, Guofu Lin, Shaohua Chen, Qinhui Lin, Jiansheng Yang, Yuan Xu and Yiming Zeng

    Citation: BMC Cancer 2022 22:115

    Content type: Research article

    Published on:

  4. The aim of this study was to investigate the epidemiological characteristics and associated risk factors of recurrent lower-grade glioma [LGG] (WHO grades II and III) according to the 2016 updated WHO classifi...

    Authors: Ruolun Wei, Chao Zhao, Jianguo Li, Fengdong Yang, Yake Xue and Xinting Wei

    Citation: BMC Cancer 2022 22:114

    Content type: Research

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  5. This retrospective study investigated biomarkers that can reflect coagulation, inflammation, and lipid abnormalities: platelet-to-albumin ratio (PAR), platelet-to lymphocyte ratio (PLR), low-density lipoprotei...

    Authors: Cong Ma, Ruizhen Li, Ronghui Yu, Jingjing Guo, Jianyun Xu, Xuhui Yuan and Jianfeng Guo

    Citation: BMC Cancer 2022 22:113

    Content type: Research

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  6. To determine how much an augmented analysis approach could improve the efficiency of prostate-specific antigen (PSA) response analyses in clinical practice. PSA response rates are commonly used outcome measure...

    Authors: Michael J. Grayling, Martina McMenamin, Robert Chandler, Rakesh Heer and James M. S. Wason

    Citation: BMC Cancer 2022 22:111

    Content type: Research

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  7. Idiopathic pulmonary fibrosis (IPF) is the most common type of interstitial pneumonia. Lung cancer, mainly non-small cell lung cancer (NSCLC), is a complication of idiopathic pulmonary fibrosis. IPF is also an...

    Authors: Wenxin Kou, Bo Li, Yeifei Shi, Yifan Zhao, Qing Yu, Jianhui Zhuang, Yawei Xu and Wenhui Peng

    Citation: BMC Cancer 2022 22:110

    Content type: Research

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  8. Older cancer patients may search for health information online to prepare for their consultations. However, seeking information online can have negative effects, for instance increased anxiety due to finding i...

    Authors: Melanie de Looper, Ellen M. A. Smets, Barbara C. Schouten, Sifra Bolle, Eric H. J. Belgers, Eric H. Eddes, Jeroen W. A. Leijtens and Julia C. M. van Weert

    Citation: BMC Cancer 2022 22:109

    Content type: Research

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  9. Osteosarcoma is an aggressive malignant bone sarcoma worldwide. A causal gene network with specific functions underlying both the development and progression of OS was still unclear. Here we firstly identified...

    Authors: Jiahua Li, Hui Shi, Zhanyuan Yuan, Zhiheng Wu, Haohao Li, Yuelong Liu, Ming Lu and Ming Lu

    Citation: BMC Cancer 2022 22:108

    Content type: Research

    Published on:

  10. The incidence rate of non-small cell lung cancer (NSCLC) has been increasing worldwide, and the correlation of circadian rhythm disruption with a raised risk of cancer and worse prognosis has been shown by acc...

    Authors: Haocheng Xian, Yuan Li, Boliang Zou, Yajuan Chen, Houqing Yin, Xuejun Li and Yan Pan

    Citation: BMC Cancer 2022 22:107

    Content type: Research

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  11. Screening supports early detection and treatment of colorectal cancer (CRC). Provision of fecal immunochemical tests/fecal occult blood tests (FIT/FOBT) in primary care can increase CRC screening, particularly...

    Authors: Cynthia M. Mojica, Rose Gunn, Robyn Pham, Edward J. Miech, Ann Romer, Stephanie Renfro, Khaya D. Clark and Melinda M. Davis

    Citation: BMC Cancer 2022 22:106

    Content type: Research article

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  12. Nutrient acquisition and metabolism pathways are altered in cancer cells to meet bioenergetic and biosynthetic demands. A major regulator of cellular metabolism and energy homeostasis, in normal and cancer cel...

    Authors: Mehrshad Sadria, Deokhwa Seo and Anita T. Layton

    Citation: BMC Cancer 2022 22:105

    Content type: Research

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  13. Administration of single-agent docetaxel in a weekly schedule may offer similar efficacy, with a more favorable toxicity profile, compared to a three-weekly schedule in patients with metastatic breast cancer.

    Authors: Maarten van Eijk, Marit A. C. Vermunt, Erik van Werkhoven, Erica A. Wilthagen, Alwin D. R. Huitema and Jos H. Beijnen

    Citation: BMC Cancer 2022 22:104

    Content type: Research article

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  14. The study aimed to assess the impact of size differences of multiple liver metastases on liver recurrence-free survival (RFS) in patients undergoing hepatic resection for colorectal liver metastases (CRLMs).

    Authors: Yana Zhai, Weijun Bai, Jin Zhou, Qian Dong and Jingdong Zhang

    Citation: BMC Cancer 2022 22:103

    Content type: Research article

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  15. Treatment outcomes of advanced non-small cell lung cancer (NSCLC) have substantially improved with immune checkpoint inhibitors (ICI), although only approximately 19% of patients respond to immunotherapy alone...

    Authors: Andrew F. Nyein, Shahla Bari, Stephanie Hogue, Yayi Zhao, Bradley Maller, Sybil Sha, Maria F. Gomez, Dana E. Rollison and Lary A. Robinson

    Citation: BMC Cancer 2022 22:101

    Content type: Research

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  16. Platinum chemoresistance results in high-grade serous ovarian cancer (HGSOC) disease recurrence. Recent treatment advances using checkpoint inhibitor immunotherapy has not benefited platinum-resistant HGSOC. I...

    Authors: Michelle W. Wong-Brown, Andre van der Westhuizen and Nikola A. Bowden

    Citation: BMC Cancer 2022 22:100

    Content type: Research

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  17. The gut microbiome is implicated as a marker of response to  immune checkpoint inhibitors (ICI) based on preclinical mouse models and preliminary observations in limited patient series. Furthermore, early stud...

    Authors: Nicola A. Thompson, Grant D. Stewart, Sarah J. Welsh, Gary J. Doherty, Matthew J. Robinson, B. Anne Neville, Kevin Vervier, Simon R. Harris, David J. Adams, Katy Dalchau, David Bruce, Nikolaos Demiris, Trevor D. Lawley and Pippa G. Corrie

    Citation: BMC Cancer 2022 22:99

    Content type: Study protocol

    Published on:

  18. Recently, chimeric antigen receptor-modified (CAR) T cell therapy for hematological malignancies has shown clinical efficacy. Hundreds of clinical trials have been registered and lots of studies have shown hem...

    Authors: Wenjing Luo, Chenggong Li, Yinqiang Zhang, Mengyi Du, Haiming Kou, Cong Lu, Heng Mei and Yu Hu

    Citation: BMC Cancer 2022 22:98

    Content type: Research article

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  19. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Salonee Shah, Kerri Beckmann, Mieke Van Hemelrijck, Ben Challacombe, Rick Popert, Prokar Dasgupta, Jonah Rusere, Grace Zisengwe, Oussama Elhage and Aida Santaolalla

    Citation: BMC Cancer 2022 22:97

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2021 21:573

  20. To explore the maximum tolerated dose (MTD) and evaluate the safety of dose escalation using hypofractionated simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) concurrent with chemother...

    Authors: Qin Zhang, Xu-Wei Cai, Wen Feng, Wen Yu and Xiao-Long Fu

    Citation: BMC Cancer 2022 22:96

    Content type: Research

    Published on:

  21. Dietary patterns and symptoms research among Chinese with esophageal squamous cell carcinoma (ESCC) and its precursor lesions is limited, especially as it relates to multiple food consumption and multiple co-o...

    Authors: Zhaoping Zang, Yong Liu, Jialin Wang, Yuqin Liu, Shaokai Zhang, Yongzhen Zhang, Liwei Zhang, Deli Zhao, Fugang Liu, Lina Chao, Xinzheng Wang, Chunli Zhang, Guohui Song, Zhiyi Zhang, Youpeng Li, Zheng Yan…

    Citation: BMC Cancer 2022 22:95

    Content type: Research

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  22. Preoperative chemotherapy is widely applied to high-grade localized soft tissue sarcomas (STSs); however, the prognostic significance of histological response to chemotherapy remains controversial. This study ...

    Authors: Yoshinao Oda, Kazuhiro Tanaka, Takanori Hirose, Tadashi Hasegawa, Nobuyuki Hiruta, Masanori Hisaoka, Masato Yoshimoto, Hiroshi Otsuka, Hirofumi Bekki, Takeaki Ishii, Makoto Endo, Toshiyuki Kunisada, Toru Hiruma, Hiroyuki Tsuchiya, Hirohisa Katagiri, Yoshihiro Matsumoto…

    Citation: BMC Cancer 2022 22:94

    Content type: Research

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  23. Serum cholinesterase (ChE) was found to be involved in cancer initiation and progression. However, the survival association between serum ChE and non-small cell lung cancer (NSCLC) has not been extensively dis...

    Authors: Hailiang Ran, Jie Ma, Le Cai, Hai Zhou, Zhongqin Yuan, Ying Chen, Wei Chang, Yunchao Huang and Yuanyuan Xiao

    Citation: BMC Cancer 2022 22:93

    Content type: Research

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  24. Hepatocellular carcinoma (HCC) is the sixth most common form of cancer worldwide. Although surgical treatments have an acceptable cure rate, tumor recurrence is still a challenging issue. In this meta-analysis...

    Authors: Elias Khajeh, Arash Dooghaie Moghadam, Pegah Eslami, Sadeq Ali-Hasan-Al-Saegh, Ali Ramouz, Saeed Shafiei, Omid Ghamarnejad, Sepehr Abbasi Dezfouli, Christian Rupp, Christoph Springfeld, Carlos Carvalho, Pascal Probst, Seyed Mostafa Mousavizadeh and Arianeb Mehrabi

    Citation: BMC Cancer 2022 22:91

    Content type: Research

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  25. Oral mucositis (OM) associated with cancer treatment not only impairs patients’ quality of life but also causes treatment delays or changes. This prospective exploratory study was conducted to evaluate the eff...

    Authors: Takao Ueno, Wakako Yatsuoka, Hiroto Ishiki, Kanako Miyano and Yasuhito Uezono

    Citation: BMC Cancer 2022 22:90

    Content type: Research

    Published on:

  26. Radiotherapy is a highly effective treatment for cervical cancer. Recent studies focused on the radiotherapy induced anti-tumor immunity. Whether tumor-derived extracellular vesicles (EVs) play roles in radiot...

    Authors: Junli Ren, Lili Li, Baofeng Yu, Enwei Xu, Naiping Sun, Xiaoning Li, Zihan Xing, Xiaodong Han, Yaqin Cui, Xiaoyan Wang, Xiaoxue Zhang and Guoliang Wang

    Citation: BMC Cancer 2022 22:88

    Content type: Research

    Published on:

  27. Uterine cervical cancer (UCC) was the fourth leading cause of cancer death among women worldwide. The conventional MRI hardly revealing the microstructure information. This study aimed to compare the value of ...

    Authors: Mengyan Hou, Kai Song, Jipeng Ren, Kaiyu Wang, Jinxia Guo, Yongchao Niu, Zhenyu Li and Dongming Han

    Citation: BMC Cancer 2022 22:87

    Content type: Research

    Published on:

  28. Circulating cell-free DNA (cfDNA) in the plasma of cancer patients contains cell-free tumour DNA (ctDNA) derived from tumour cells and it has been widely recognized as a non-invasive source of tumour DNA for d...

    Authors: Devika Ganesamoorthy, Alan James Robertson, Wenhan Chen, Michael B. Hall, Minh Duc Cao, Kaltin Ferguson, Sunil R. Lakhani, Katia Nones, Peter T. Simpson and Lachlan J. M. Coin

    Citation: BMC Cancer 2022 22:85

    Content type: Research article

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  29. Activated Cdc42-associated kinase 1 (ACK1), a kind of tyrosine kinase, is considered to be an oncogene in many cancers, and it is likely to become a potential target for cancer treatment. We found that the exp...

    Authors: Defeng Kong, Guoliang Li, Zhenrong Yang, Shujun Cheng, Wen Zhang, Lin Feng and Kaitai Zhang

    Citation: BMC Cancer 2022 22:84

    Content type: Research

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  30. Cancer cells prefer utilizing aerobic glycolysis in order to exacerbate tumor mass and maintain un-regulated proliferative rates. As a key glycolytic activator, phosphofructo-2-kinase/fructose-2,6-bisphosphata...

    Authors: Jun Li, Shiqiang Zhang, Dingzhun Liao, Qian Zhang, Chujie Chen, Xiangwei Yang, Donggen Jiang and Jun Pang

    Citation: BMC Cancer 2022 22:83

    Content type: Research

    Published on:

  31. Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority of patients with ESCC in Eastern Africa present with advanced disease at the time of...

    Authors: Geoffrey C. Buckle, Alita Mrema, Michael Mwachiro, Yona Ringo, Msiba Selekwa, Gift Mulima, Fatma F. Some, Blandina T. Mmbaga, Gita N. Mody, Li Zhang, Alan Paciorek, Larry Akoko, Paul Ayuo, Stephen Burgert, Elizabeth Bukusi, Anthony Charles…

    Citation: BMC Cancer 2022 22:82

    Content type: Study protocol

    Published on:

  32. Lung cancer (LC) is the most commonly diagnosed cancer and the leading cause of cancer-related death in both sexes worldwide. Although the principal risk factor in the western world is tobacco smoking, genetic...

    Authors: Ramón Antonio Tubío-Pérez, María Torres-Durán, María Esmeralda García-Rodríguez, Cristina Candal-Pedreira, Julia Rey-Brandariz, Mónica Pérez-Ríos, Juan Barros-Dios, Alberto Fernández-Villar and Alberto Ruano-Raviña

    Citation: BMC Cancer 2022 22:81

    Content type: Research

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  33. It has been postulated that patient’s sex impacts response to immunotherapy. Sex modulation of immunotherapy benefit, however, has not yet been explored using patient-level data, where potential confounders, a...

    Authors: Stephanie Tuminello, Naomi Alpert, Rajwanth R. Veluswamy, Arvind Kumar, Jorge E. Gomez, Raja Flores and Emanuela Taioli

    Citation: BMC Cancer 2022 22:80

    Content type: Research

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  34. Long non-coding RNA (LncRNA) HOTAIR was amplified and overexpressed in many human carcinomas, which could serve as a useful target for cancer early detection and treatment. The 99mTc radiolabeled antisense oligon...

    Authors: Jiongyu Ren, Xiyuan Zhang, Jiang Cao, Jiali Tian, Jin Luo, Yaping Yu, Fengkui Wang and Qian Zhao

    Citation: BMC Cancer 2022 22:79

    Content type: Research

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  35. Sarcopenia is defined by a loss of muscle strength associated to a decrease in skeletal muscle mass. Ageing greatly contributes to sarcopenia as may many other factors such as cancer or androgen deprivation th...

    Authors: Anne-Laure Couderc, Patrick Villani, Julie Berbis, Emilie Nouguerède, Dominique Rey, Dominique Rossi, Éric Lechevallier, Delphine Badinand, Cyrille Bastide, Gilles Karsenty, Romain Boissier, Kahena Amichi and Xavier Muracciole

    Citation: BMC Cancer 2022 22:78

    Content type: Study protocol

    Published on:

  36. The impact of hepatic resection for liver metastases (LM) on the survival of pediatric patients with Wilms’ tumor (WT) is unclear. So far, there is a lack of studies investigating the best suited treatment for...

    Authors: Juri Fuchs, Anastasia Murtha-Lemekhova, Markus Kessler, Patrick Günther and Katrin Hoffmann

    Citation: BMC Cancer 2022 22:76

    Content type: Research

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  37. Cancer patients experience increased risk of death from accident and suicide. Cognitive impairment induced by cancer-related inflammation and stress-related psychiatric symptoms may be underlying mechanisms. W...

    Authors: Qing Shen, Arvid Sjölander, Erica K. Sloan, Adam K. Walker, Katja Fall, Unnur Valdimarsdottir, Pär Sparén, Karin E. Smedby and Fang Fang

    Citation: BMC Cancer 2022 22:75

    Content type: Research

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  38. Microsatellite instability (MSI) is a key marker for predicting the response of immune checkpoint inhibitors (ICIs) and for screening Lynch syndrome (LS).

    Authors: Hiroyuki Matsubayashi, Satomi Higashigawa, Yoshimi Kiyozumi, Takuma Oishi, Keiko Sasaki, Hirotoshi Ishiwatari, Kenichiro Imai, Kinichi Hotta, Yohei Yabuuchi, Kazuma Ishikawa, Tatsunori Satoh, Hiroyuki Ono, Akiko Todaka, Takeshi Kawakami, Hiromichi Shirasu, Hirofumi Yasui…

    Citation: BMC Cancer 2022 22:73

    Content type: Research

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  39. Transcripts with alternative 5′-untranslated regions (UTRs) result from the activity of alternative promoters and they can determine gene expression by influencing its stability and translational efficiency, t...

    Authors: Tamara Babic, Sandra Dragicevic, Marko Miladinov, Zoran Krivokapic and Aleksandra Nikolic

    Citation: BMC Cancer 2022 22:72

    Content type: Research

    Published on:

  40. As segmentectomy had become commonly used for Non-Small Cell Lung Cancer (NSCLC) treatment, which had the advantages of radical operation, however, it remains controversial owing to procedural complexity and r...

    Authors: Yaodong Zhou, Tao Yu, Yixin Zhang, Liqiang Qian and Qing Xia

    Citation: BMC Cancer 2022 22:71

    Content type: Research

    Published on:

  41. It is unknown whether and to what degree trials submitted to the US FDA to support drug approval adhere to NCCN guideline-recommended care in their baseline and surveillance CNS imaging protocols.

    Authors: John Sharp and Vinay Prasad

    Citation: BMC Cancer 2022 22:70

    Content type: Research

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  42. The Predicting Risk of Cancer at Screening (PROCAS) study provided women who were eligible for breast cancer screening in Greater Manchester (United Kingdom) with their 10-year risk of breast cancer, i.e., low...

    Authors: Linda Rainey, Daniëlle van der Waal, Louise S. Donnelly, Jake Southworth, David P. French, D. Gareth Evans and Mireille J. M. Broeders

    Citation: BMC Cancer 2022 22:69

    Content type: Research

    Published on:

  43. Neoadjuvant chemoradiation therapy (nCRT) is the standard treatment modality in locally advanced rectal cancer (LARC). Since response to radiotherapy (RT) is dose dependent in rectal cancer, dose escalation ma...

    Authors: Giuditta Chiloiro, Davide Cusumano, Luca Boldrini, Angela Romano, Lorenzo Placidi, Matteo Nardini, Elisa Meldolesi, Brunella Barbaro, Claudio Coco, Antonio Crucitti, Roberto Persiani, Lucio Petruzziello, Riccardo Ricci, Lisa Salvatore, Luigi Sofo, Sergio Alfieri…

    Citation: BMC Cancer 2022 22:67

    Content type: Study protocol

    Published on:

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