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  1. Content type: Research article

    The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, brea...

    Authors: Swetlana Rot, Tom Kaune, Helge Taubert, Thomas Greither, Johanna Kotrba, Antje Güttler, Henri Wichmann, Udo Bilkenroth, Andreas Wienke, Bilal Al-Nawas, Matthias Bache, Dirk Vordermark, Claudia Wickenhauser, Daniel Bethmann, Alexander W. Eckert and Matthias Kappler

    Citation: BMC Cancer 2019 19:155

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  2. Content type: Research article

    Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells)....

    Authors: Mingshui Chen, Aditi Sharma, Yanling Lin, Yanheng Wu, Qi He, Yushu Gu, Zhi Ping Xu, Michael Monteiro and Wenyi Gu

    Citation: BMC Cancer 2019 19:153

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  3. Content type: Research article

    The aim of this study was to evaluate the prevalence of some gynecological cancer risk factors in a population of female relatives of cancer patients in Hacettepe University Oncology Hospital. Additionally, wh...

    Authors: Nooria Atta, Saadettin Kilickap, Deniz Yuce and Mutlu Hayran

    Citation: BMC Cancer 2019 19:154

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  4. Content type: Correction

    Following publication of the original article [1], the authors notified us of an error in the reported percentages in Table 3.

    Authors: Charlotte Woodhead, Ruth Cunningham, Mark Ashworth, Elizabeth Barley, Robert J. Stewart and Max J. Henderson

    Citation: BMC Cancer 2019 19:152

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    The original article was published in BMC Cancer 2016 16:819

  5. Content type: Research article

    We analyzed the efficacy and toxicity of cabazitaxel (CBZ) at high and low initial doses in Japanese patients with docetaxel-resistant castration-resistant prostate cancer (CRPC).

    Authors: Naoki Terada, Toshiyuki Kamoto, Hiromasa Tsukino, Shoichiro Mukai, Shusuke Akamatsu, Takahiro Inoue, Osamu Ogawa, Shintaro Narita, Tomonori Habuchi, Shinichi Yamashita, Koji Mitsuzuka, Yoichi Arai, Shuya Kandori, Takahiro Kojima, Hiroyuki Nishiyama, Yoshiaki Kawamura…

    Citation: BMC Cancer 2019 19:156

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  6. Content type: Research article

    Cognitive impairment is commonly reported in patients receiving chemotherapy, but the acuity of onset is not known. This study utilized the psychomotor vigilance test (PVT) and trail-making test B (TMT-B) to a...

    Authors: Omar F. Khan, Ellen Cusano, Soundouss Raissouni, Mica Pabia, Johanna Haeseker, Nicholas Bosma, Jenny J. Ko, Haocheng Li, Aalok Kumar, Michael M. Vickers and Patricia A. Tang

    Citation: BMC Cancer 2019 19:150

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  7. Content type: Research article

    Chemotherapy-induced thrombocytopenia (CIT) is a potentially serious complication that can lead to chemotherapy dose delays, dose reductions, or discontinuation, and increases the risk of serious bleeding even...

    Authors: Derek Weycker, Mark Hatfield, Aaron Grossman, Ahuva Hanau, Alex Lonshteyn, Anjali Sharma and David Chandler

    Citation: BMC Cancer 2019 19:151

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  8. Content type: Research article

    The brain is a common site for metastasis in non-small-cell lung cancer (NSCLC). This study was designed to evaluate the relationship between the mutational of the epidermal growth factor receptor (EGFR) and o...

    Authors: Wen-Ya Li, Ting-Ting Zhao, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yunan Han, Yong-Xi Song, Jian-Hua Wu, Hao Xu, Song-Cheng Yin, Xing-Yu Liu and Zhi-Feng Miao

    Citation: BMC Cancer 2019 19:145

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  9. Content type: Research article

    A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. H...

    Authors: Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae-Jung Kim, Seong-Beom Lee, Sug Hyung Lee, Jong Y. Park, Mi Sun Park, Hyeon Woo Yim and Seung Joon Kim

    Citation: BMC Cancer 2019 19:148

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  10. Content type: Research article

    Chemotherapy-induced alopecia has been well documented as a cause of distress to patients undergoing cancer treatment. Almost all traditional chemotherapeutic agents cause severe alopecia. Despite advances in ...

    Authors: Young-Cheol Lim, Hyeongi Kim, Sang Moo Lim and Jin Su Kim

    Citation: BMC Cancer 2019 19:149

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  11. Content type: Research article

    Previous related studies have mainly focused on renal cell carcinoma (RCC) with venous tumor thrombus, specifically inferior vena cava tumor thrombus with renal vein tumor thrombus (RVTT). However, only a few ...

    Authors: Chuanzhen Cao, Xingang Bi, Jing Liang, Lin Li, Huijuan Zhang, Zhendong Xiao, Zejun Xiao, Jun Tian, Dong Wang, Kaopeng Guan, Changling Li, Jianhui Ma, Shan Zheng and Jianzhong Shou

    Citation: BMC Cancer 2019 19:144

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  12. Content type: Research article

    The patient satisfaction of symptoms improvement and disease factors that may affect long-term treatment efficacy of radiofrequency ablation (RFA) for non-functioning solid benign thyroid nodules (TNs) over a ...

    Authors: Yang Guang, Wen He, Yukun Luo, Hongxia Zhang, Yukang Zhang, Bin Ning and Tengfei Yu

    Citation: BMC Cancer 2019 19:147

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  13. Content type: Research article

    Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the progno...

    Authors: Ann C. Eriksen, Flemming B. Sørensen, Jan Lindebjerg, Henrik Hager, René dePont Christensen, Sanne Kjær-Frifeldt and Torben F. Hansen

    Citation: BMC Cancer 2019 19:142

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  14. Content type: Research article

    The prognostic value of body composition in cancer patients has been widely studied during the last decade. The main finding of these studies is that sarcopenia, or skeletal muscle depletion, assessed by CT im...

    Authors: Nicolas Charette, Caroline Vandeputte, Lieveke Ameye, Camille Van Bogaert, Jonathan Krygier, Thomas Guiot, Amélie Deleporte, Thierry Delaunoit, Karen Geboes, Jean-Luc Van Laethem, Marc Peeters, Gauthier Demolin, Stéphane Holbrechts, Patrick Flamen, Marianne Paesmans and Alain Hendlisz

    Citation: BMC Cancer 2019 19:134

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  15. Content type: Research article

    The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different ...

    Authors: Mengxi Ge, Qiong Zhan, Zhenzhen Zhang, Xiaoyu Ji, Xinli Zhou, Ruofan Huang and Xiaohua Liang

    Citation: BMC Cancer 2019 19:143

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  16. Content type: Research article

    Despite the recent progress in the development of anti-cancer drugs, the treatment of metastatic tumors is usually ineffective. The systemic inflammatory response performs key roles in different stages of the ...

    Authors: O. Abu-Shawer, M. Abu-Shawer, N. Hirmas, A. Alhouri, A. Massad, B. Alsibai, H. Sultan, H. Hammo, M. Souleiman, Y. Shebli and M. Al-Hussaini

    Citation: BMC Cancer 2019 19:141

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  17. Content type: Research article

    Intracranial and intraspinal tumours are the most numerous solid tumours in children. Some recently defined subtypes are relatively frequent in childhood. Many cancer registries routinely ascertain CNS tumours...

    Authors: Charles A. Stiller, Anita M. Bayne, Aruna Chakrabarty, Tom Kenny and Paul Chumas

    Citation: BMC Cancer 2019 19:139

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  18. Content type: Research article

    MicroRNAs are noncoding RNA molecules of ~ 22 nucleotides with diagnostic and therapeutic action [Curr Drug Targets, 2015. 16(12): p. 1381-403], affecting the expression of mRNAs involved in invasion, migratio...

    Authors: Olga D’Almeida, Omar Mothar, Esther Apraku Bondzie, Yolande Lieumo, Laure Tagne, Sumeet Gupta, Thomas Volkert, Stuart Levine and Jean-Bosco Tagne

    Citation: BMC Cancer 2019 19:136

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  19. Content type: Research article

    Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer pro...

    Authors: Cassandra Ringuette Goulet, Audrey Champagne, Geneviève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot and Stéphane Bolduc

    Citation: BMC Cancer 2019 19:137

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  20. Content type: Research article

    Evidence from clinical trials suggests that the addition of bevacizumab to chemotherapy in the first-line treatment of patients with HER2-negative metastatic breast cancer improves progression-free survival (P...

    Authors: Audrey Petitjean, Jayne Smith-Palmer, William Valentine, Bertrand Tehard and Stephané Roze

    Citation: BMC Cancer 2019 19:140

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  21. Content type: Research article

    Human papillomavirus (HPV) is an etiological agent of cervical cancer. Yet co-factors are believed to be involved in HPV-mediated carcinogenesis. Polycyclic aromatic hydrocarbons (PAHs) are considered as one o...

    Authors: Chuqing Zhang, Yunjing Luo, Rugang Zhong, Priscilla T. Y. Law, Siaw Shi Boon, Zigui Chen, Chi-Hang Wong and Paul K. S. Chan

    Citation: BMC Cancer 2019 19:138

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  22. Content type: Research article

    Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. Examination of the 5′ promoter regions of trefoil factor 3 (TFF3) gene has identified putative estrogen a...

    Authors: Suhail Al-Salam, Manjusha Sudhadevi, Aktham Awwad and Mohamed Al Bashir

    Citation: BMC Cancer 2019 19:135

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  23. Content type: Research article

    Differentiating between cancer patients who will experience metastasis within a short time and who will be long-term survivors without metastasis is a critical aim in healthcare. The microsatellite instability...

    Authors: Michelle E. Penney, Patrick S. Parfrey, Sevtap Savas and Yildiz E. Yilmaz

    Citation: BMC Cancer 2019 19:133

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  24. Content type: Research article

    Serum exosomal microRNAs (miRNAs) have been suggested as novel biomarkers for various diseases, especially gastric cancer (GC). But circulating biomarkers for Chronic atrophic gastritis (CAG) which is defined ...

    Authors: Hong Liu, Pei-wu Li, Wei-qin Yang, Hong Mi, Jing-lin Pan, Yuan-cheng Huang, Zheng-kun Hou, Qiu-ke Hou, Qi Luo and Feng-bin Liu

    Citation: BMC Cancer 2019 19:129

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  25. Content type: Research article

    There are inconsistencies in the literature regarding the prevalence and assessment of chemotherapy-induced peripheral neuropathy (CIPN). This study explored CIPN natural history and its characteristics in pat...

    Authors: Alex Molassiotis, Hui Lin Cheng, Violeta Lopez, Joseph S. K. Au, Alexandre Chan, Aishwarya Bandla, K. T. Leung, Y. C. Li, K. H. Wong, Lorna K. P. Suen, Choi Wan Chan, Janelle Yorke, Carole Farrell and Raghav Sundar

    Citation: BMC Cancer 2019 19:132

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  26. Content type: Research article

    Cancer is the leading cause of death in the developed world, and yet healthcare practitioners infrequently discuss goals of care (GoC) with hospitalized cancer patients. We sought to identify barriers to GoC d...

    Authors: Katrina Lynn Piggott, Ameen Patel, Arthur Wong, Leslie Martin, Alexandra Patel, Matthew Patel, Yudong Liu, Sukhbinder Dhesy-Thind and John J. You

    Citation: BMC Cancer 2019 19:130

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  27. Content type: Case report

    Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have been emerged as the standard selection in non-small cell lung cancer (NSCLC) patients with EGFR sensitive mutations. However, primar...

    Authors: Junhui Wang and Jianxin Chen

    Citation: BMC Cancer 2019 19:131

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  28. Content type: Research article

    Considering the lack of efficient breast cancer prediction models suitable for general population screening in China. We aimed to develop a risk prediction model to identify high-risk populations, to help with...

    Authors: Lu Wang, Liyuan Liu, Zhen Lou, Lijie Ding, Hui Guan, Fei Wang, Lixiang Yu, Yujuan Xiang, Fei Zhou, Fuzhong Xue and Zhigang Yu

    Citation: BMC Cancer 2019 19:128

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  29. Content type: Research article

    We conducted a randomized trial to evaluate the efficacy of heparinoid moisturization for radiation dermatitis. We report the time-course of sebum content after whole breast radiotherapy (WBRT) and the efficac...

    Authors: Mami Ogita, Kenji Sekiguchi, Keiko Akahane, Ryoko Ito, Chiori Haga, Satoru Arai, Yasushi Ishida and Jiro Kawamori

    Citation: BMC Cancer 2019 19:125

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  30. Content type: Research article

    Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere...

    Authors: Carla De Giovanni, Patrizia Nanni, Lorena Landuzzi, Marianna L. Ianzano, Giordano Nicoletti, Stefania Croci, Arianna Palladini and Pier-Luigi Lollini

    Citation: BMC Cancer 2019 19:126

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  31. Content type: Correction

    Following publication of the original article [1], we have been notified that the authors’ last names have been incorrectly tagged as first names and vice-versa. The original publication has been corrected.

    Authors: Gautier Marcq, Aude Michelet, Gerjon Hannink, Jerome Rizk, Jean Sauvain, Arnauld Villers, Mo Saffarini and Charles-Henry Rochat

    Citation: BMC Cancer 2019 19:124

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    The original article was published in BMC Cancer 2018 18:1291

  32. Content type: Research article

    The prognostic value of Ki-67 expression in colorectal cancer patients was controversial. Therefore, this meta analysis was conducted to ascertain the prognostic value of Ki-67 expression in colorectal cancer ...

    Authors: Zhao-Wen Luo, Ming-Gu Zhu, Zhi-Qiao Zhang, Feng-Jun Ye, Wen-Heng Huang and Xue-Zhang Luo

    Citation: BMC Cancer 2019 19:123

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  33. Content type: Research article

    Treatment with recombinant human granulocyte-colony stimulating factor (G-CSF) is accepted standard for prevention of chemotherapy-induced neutropenia. RGB-02 (Gedeon Richter) is a proposed biosimilar to pegyl...

    Authors: Zsuzsanna Kahan, Daniela Grecea, Martin Smakal, Sergei Tjulandin, Igor Bondarenko, Luca Perjesi, Andras Illes, Karoly Horvat-Karajz and Ildiko Aradi

    Citation: BMC Cancer 2019 19:122

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  34. Content type: Study protocol

    Induction chemotherapy followed by chemoradiation is a treatment option for patients with locally advanced pancreatic cancer (LAPC). However, overall survival is comparable to chemotherapy alone and local prog...

    Authors: Victoria Y. Strauss, Rachel Shaw, Pradeep S. Virdee, Christopher N. Hurt, Elizabeth Ward, Bethan Tranter, Neel Patel, John Bridgewater, Philip Parsons, Ganesh Radhakrishna, Eric O’Neill, David Sebag-Montefiore, Maria Hawkins, Pippa G. Corrie, Timothy Maughan and Somnath Mukherjee

    Citation: BMC Cancer 2019 19:121

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  35. Content type: Research article

    The CD133 transmembrane protein is a well-recognized stem cell marker that has been used to isolate putative cancer stem cell populations from gastric cancers (GCs). However, the molecular features or biomarke...

    Authors: Tae-Min Kim, Yoon Ho Ko, Shin Jung Ha and Han Hong Lee

    Citation: BMC Cancer 2019 19:119

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  36. Content type: Research article

    Tumor-infiltrating lymphocytes (TILs) are described as an important immune modulator in the tumor microenvironment and are associated with breast cancer (BC) outcome. The spatial analysis of TILs and TIL subty...

    Authors: Lisa König, Fabian D. Mairinger, Oliver Hoffmann, Ann-Kathrin Bittner, Kurt W. Schmid, Rainer Kimmig, Sabine Kasimir-Bauer and Agnes Bankfalvi

    Citation: BMC Cancer 2019 19:120

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  37. Content type: Research article

    Patients with advanced disease experience high levels of psychological distress, yet there is low uptake of psychosocial services offered to patients who screened positive for distress. In this study we aimed ...

    Authors: Claudia S. E. W. Schuurhuizen, Annemarie M. J. Braamse, Inge R. H. M. Konings, Henk M. W. Verheul and Joost Dekker

    Citation: BMC Cancer 2019 19:115

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  38. Content type: Research article

    Heterozygous germline TP53 gene mutations result in Li-Fraumeni Syndrome (LFS). Breast cancer (BC) is the most frequent tumor in young women with LFS. An important issue related to BC in the Mexican population is...

    Authors: Lenny N. Gallardo-Alvarado, María Teresa Tusié-Luna, María Isabel Tussié-Luna, José Díaz-Chávez, Yayoi X. Segura, Enrique Bargallo-Rocha, Cynthia Villarreal, Luis A. Herrera-Montalvo, Enrique M. Herrera-Medina and David F. Cantu-de Leon

    Citation: BMC Cancer 2019 19:118

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  39. Content type: Research article

    Significant numbers of variants detected in cancer patients are often left labeled only as variants of unknown significance (VUS). In order to expand precision medicine to a wider population, we need to extend...

    Authors: Takahiko Koyama, Kahn Rhrissorrakrai and Laxmi Parida

    Citation: BMC Cancer 2019 19:114

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  40. Content type: Research article

    In recent years, PD-1/PD-L1 immune checkpoint inhibitors have improved cancer therapy in many tumor types, but no benefit of immune checkpoint therapy has been found in glioblastoma multiforme (GBM). Based on ...

    Authors: Sabrina Heynckes, Karam Daka, Pamela Franco, Annette Gaebelein, Jan Hendrik Frenking, Roberto Doria-Medina, Irina Mader, Daniel Delev, Oliver Schnell and Dieter Henrik Heiland

    Citation: BMC Cancer 2019 19:117

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  41. Content type: Case report

    Synovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma a...

    Authors: Taketsugu Fujibuchi, Joji Miyawaki, Teruki Kidani, Hiroshi Imai, Hiroshi Kiyomatsu, Riko Kitazawa and Hiromasa Miura

    Citation: BMC Cancer 2019 19:116

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  42. Content type: Research article

    Genetic polymorphisms in genes involved in pain modulation have been reported to be associated to opioid efficacy and safety in different clinical settings.

    Authors: Ersilia Lucenteforte, Alfredo Vannacci, Giada Crescioli, Niccolò Lombardi, Laura Vagnoli, Laura Giunti, Valentina Cetica, Maria Luisa Coniglio, Alessandra Pugi, Roberto Bonaiuti, Maurizio Aricò, Sabrina Giglio, Andrea Messeri, Roberto Barale, Lisa Giovannelli, Alessandro Mugelli…

    Citation: BMC Cancer 2019 19:113

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  43. Content type: Research article

    The Swiss Federal Office of Public Health has recommended vaccination against human papillomavirus (HPV) to prevent cervical cancer since 2008. To establish monitoring of the future public health impact of vac...

    Authors: Dianne Egli-Gany, Anne Spaar Zographos, Joachim Diebold, Virginie Masserey Spicher, Brigitte Frey Tirri, Rolf Heusser, Joakim Dillner, Patrick Petignat, Roland Sahli and Nicola Low

    Citation: BMC Cancer 2019 19:111

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  44. Content type: Research article

    Metastatic breast cancer (MBC) prognosis is variable, depending on several clinical and biological factors. A better prediction of a patient’s outcome could allow for a more accurate choice of treatments. The ...

    Authors: Amélie Darlix, Christophe Hirtz, Simon Thezenas, Aleksandra Maceski, Audrey Gabelle, Evelyne Lopez-Crapez, Hélène De Forges, Nelly Firmin, Séverine Guiu, William Jacot and Sylvain Lehmann

    Citation: BMC Cancer 2019 19:110

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  45. Content type: Research article

    Malignant pleural mesothelioma (MPM) is a tumour arising from pleural cavities with poor prognosis. Multimodality treatment with pemetrexed combined with cisplatin shows unsatisfying response-rates of 40%. The...

    Authors: Sabrina Borchert, Michael Wessolly, Jan Schmeller, Elena Mairinger, Jens Kollmeier, Thomas Hager, Thomas Mairinger, Thomas Herold, Daniel C. Christoph, Robert F. H. Walter, Wilfried E. E. Eberhardt, Till Plönes, Jeremias Wohlschlaeger, Clemens Aigner, Kurt Werner Schmid and Fabian D. Mairinger

    Citation: BMC Cancer 2019 19:108

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  46. Content type: Research article

    Low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by colposcopy guided biopsy is recommended conservative follow-up, although some of these lesions are a...

    Authors: Jing Ye, Xiao-dong Cheng, Bei Cheng, Yi-fan Cheng, Xiao-Jing Chen and Wei-guo Lu

    Citation: BMC Cancer 2019 19:112

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  47. Content type: Research article

    MiRNAs that are potential biomarkers for predicting prognosis for acute myeloid leukemia (AML) have been identified. However, comprehensive analyses investigating the association between miRNA expression profi...

    Authors: Yao Xue, Yuqiu Ge, Meiyun Kang, Cong Wu, Yaping Wang, Liucheng Rong and Yongjun Fang

    Citation: BMC Cancer 2019 19:109

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  48. Content type: Research article

    MYCN amplification directly correlates with the clinical course of neuroblastoma and poor patient survival, and serves as the most critical negative prognostic marker. Although fluorescence in situ hybridizati...

    Authors: Dinesh Babu Somasundaram, Sheeja Aravindan, Zhongxin Yu, Muralidharan Jayaraman, Ngoc T. B. Tran, Shibo Li, Terence S. Herman and Natarajan Aravindan

    Citation: BMC Cancer 2019 19:106

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