Skip to main content

Articles

Page 1 of 233

  1. Long non-coding RNAs (LncRNAs) are dysregulated in multiple human cancers and they are highly involved in tumor progression. Previous studies have identified the oncogenic lncRNA HOXD cluster antisense RNA 1 (...

    Authors: Shaozheng Chen and Kejun Li

    Citation: BMC Cancer 2020 20:924

    Content type: Research article

    Published on:

  2. Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK) is a web-based application that facilitates symptom screening and access to supportive care clinical practice guidelines (CPGs) f...

    Authors: Cody Z. Watling, Clodagh McCarthy, Alexandra Theodorakidis, Sadie Cook, Emily Vettese, Tal Schechter, Hanan Abubeker, L. Lee Dupuis and Lillian Sung

    Citation: BMC Cancer 2020 20:923

    Content type: Research article

    Published on:

  3. A large number of patients suffer recurrence after curative resection, and mortality from colon cancer remains high. The role of systemic inflammatory response, as reflected by neutrophil-to-lymphocyte ratio (...

    Authors: Junichi Mazaki, Kenji Katsumata, Kenta Kasahara, Tomoya Tago, Takahiro Wada, Hiroshi Kuwabara, Masanobu Enomoto, Tetsuo Ishizaki, Yuichi Nagakawa and Akihiko Tsuchida

    Citation: BMC Cancer 2020 20:922

    Content type: Research article

    Published on:

  4. It is a well-known fact show that the risk of developing endometrial cancer (type 1 EC) is strongly associated with obesity. In this study, selected markers, such as obesity, insulin resistance, angiogenesis a...

    Authors: Katarzyna M. Terlikowska, Bozena Dobrzycka, Robert Terlikowski, Anna Sienkiewicz, Maciej Kinalski and Slawomir J. Terlikowski

    Citation: BMC Cancer 2020 20:921

    Content type: Research article

    Published on:

  5. Bladder cancer (BC) is the 9th most common cancer worldwide, but little progress has been made in improving patient outcomes over the last 25 years. The King’s Health Partners (KHP) BC biobank was established ...

    Authors: Pinky Kotecha, Charlotte L. Moss, Deborah Enting, Cheryl Gillett, Magdalene Joseph, Debra Josephs, Sarah Rudman, Simon Hughes, Fidelma Cahill, Harriet Wylie, Anna Haire, James Rosekilly, Muhammad Shamin Khan, Rajesh Nair, Ramesh Thurairaja, Sachin Malde…

    Citation: BMC Cancer 2020 20:920

    Content type: Database

    Published on:

  6. Inflammatory cytokine markers, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-lymphocyte ratio, and platelet-to-lymphocyte ratio, play important roles as prognostic markers in several solid malig...

    Authors: Takashi Kawahara, Masashi Kato, Kenichi Tabata, Ippei Kojima, Hiroshi Yamada, Osamu Kamihira, Hideyasu Tsumura, Masatsugu Iwamura, Hiroji Uemura and Yasuhide Miyoshi

    Citation: BMC Cancer 2020 20:919

    Content type: Research article

    Published on:

  7. Identification of effective diagnostic and prognostic biomarkers of cancer is necessary for improving precision medicine. Long non-coding RNAs (lncRNAs) play an important regulatory role in tumor initiation an...

    Authors: Chunmei Fan, Jinpeng Wang, Yanyan Tang, Shanshan Zhang, Fang Xiong, Can Guo, Yanhong Zhou, Zheng Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng and Wei Xiong

    Citation: BMC Cancer 2020 20:917

    Content type: Research article

    Published on:

  8. Lung cancer is a leading cause of cancer morbidity and mortality worldwide. Several studies have suggested that Human papillomavirus (HPV) infection is an important risk factor in the development of lung cance...

    Authors: Marzieh Rezaei, Shayan Mostafaei, Amir Aghaei, Nayyerehalsadat Hosseini, Hassan Darabi, Majid Nouri, Ashkan Etemadi, Andrew O’. Neill, Javid Sadri Nahand, Hamed Mirzaei, Seamas C. Donnelly, Mohammad Doroudian and Mohsen Moghoofei

    Citation: BMC Cancer 2020 20:916

    Content type: Research article

    Published on:

  9. In the management of operable hilar cholangiocarcinoma (HC) patients with hyperbilirubinemia, preoperative biliary drainage is a measure to bring down the bilirubin to a certain level so as to avoid adverse po...

    Authors: Wong Hoi She, Tan To Cheung, Ka Wing Ma, Simon H. Y. Tsang, Wing Chiu Dai, Albert C. Y. Chan and Chung Mau Lo

    Citation: BMC Cancer 2020 20:914

    Content type: Research article

    Published on:

  10. Adjuvant gemcitabine for pancreatic cancer has limited efficacy in the clinical setting. Impaired drug metabolism is associated with treatment resistance. We aimed to evaluate the chemosensitising effect of in...

    Authors: Amber Blaauboer, Stephanie Booy, Peter M. van Koetsveld, Bas Karels, Fadime Dogan, Suzanne van Zwienen, Casper H. J. van Eijck and Leo J. Hofland

    Citation: BMC Cancer 2020 20:913

    Content type: Research article

    Published on:

  11. The incidence of oropharyngeal squamous cell carcinoma (OPSCC) in the US is rapidly increasing, driven largely by the epidemic of human papillomavirus (HPV)-mediated OPSCC. Although survival for patients with ...

    Authors: Hesham Elhalawani, Abdallah S. R. Mohamed, Baher Elgohari, Timothy A. Lin, Andrew G. Sikora, Stephen Y. Lai, Abdelrahman Abusaif, Jack Phan, William H. Morrison, G. Brandon Gunn, David I. Rosenthal, Adam S. Garden, Clifton D. Fuller and Vlad C. Sandulache

    Citation: BMC Cancer 2020 20:912

    Content type: Research article

    Published on:

  12. The study aimed to investigate the clinical features and prognosis factors of adult patients with Langerhans cell histiocytosis (LCH) with pulmonary involvement, especially multisystem (MS) LCH with pulmonary ...

    Authors: Hui-lei Miao, Ai-lin Zhao, Ming-hui Duan, Dao-bin Zhou, Xin-xin Cao and Jian Li

    Citation: BMC Cancer 2020 20:911

    Content type: Research article

    Published on:

  13. The prognosis of lung cancer was found to be associated with a series of biomarkers related to the tumor immune microenvironment (TIME), which can modulate the biological behaviors and consequent outcomes of l...

    Authors: Dantong Sun, Lu Tian, Tiantian Bian, Han Zhao, Junyan Tao, Lizong Feng, Qiaoling Liu and Helei Hou

    Citation: BMC Cancer 2020 20:910

    Content type: Research article

    Published on:

  14. Various parameters have been considered for predicting survival in pancreatic ductal adenocarcinoma. Information about western population is missing. The aim of this study is to assess the association between ...

    Authors: Mar Achalandabaso Boira, Marcello Di Martino, Carlos Gordillo, Magdalena Adrados and Elena Martín-Pérez

    Citation: BMC Cancer 2020 20:909

    Content type: Research article

    Published on:

  15. Mucinous adenocarcinoma (MC) is the second most common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLMs) are common and lethal, and complete resection of the primary tumour and me...

    Authors: Jia Huang, Guodong Chen, Huan Liu, Yiwei Zhang, Rong Tang, Qiulin Huang, Kai Fu, Xiuda Peng and Shuai Xiao

    Citation: BMC Cancer 2020 20:908

    Content type: Research article

    Published on:

  16. Several systemic inflammatory response (SIR) markers, including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and albumin-to-globulin ratio (AGR)...

    Authors: Gunn Huh, Ji Kon Ryu, Jung Won Chun, Joo Seong Kim, Namyoung Park, In Rae Cho, Woo Hyun Paik, Sang Hyub Lee and Yong-Tae Kim

    Citation: BMC Cancer 2020 20:907

    Content type: Research article

    Published on:

  17. Pancreatic neuroendocrine neoplasms (p-NENs) are a group of highly heterogeneous tumors with distinct clinicopathological features and long-term prognosis. In 2017, in order to better stratify patients into pr...

    Authors: Min Yang, Lin Zeng, Neng-wen Ke, Chun-lu Tan, Bo-le Tian, Xu-bao Liu, Bo Xiang and Yi Zhang

    Citation: BMC Cancer 2020 20:906

    Content type: Research article

    Published on:

  18. A low level of methylation at cg05575921 in the aryl-hydrocarbon receptor repressor (AHRR) gene is robustly associated with smoking, and some studies have observed associations between cg05575921 methylation and ...

    Authors: Laurie Grieshober, Stefan Graw, Matt J. Barnett, Mark D. Thornquist, Gary E. Goodman, Chu Chen, Devin C. Koestler, Carmen J. Marsit and Jennifer A. Doherty

    Citation: BMC Cancer 2020 20:905

    Content type: Research article

    Published on:

  19. This case-control study investigated the role of Chlamydia pneumoniae (Cpn) infection in the pathogenesis of lung cancer and the combined and interaction effect of Cpn infection, smoking, and various environmenta...

    Authors: Xin Xu, Zhiqiang Liu, Weimin Xiong, Minglian Qiu, Shuling Kang, Qiuping Xu, Lin Cai and Fei He

    Citation: BMC Cancer 2020 20:903

    Content type: Research article

    Published on:

  20. High resolution melting curve analysis is a cost-effective rapid screening method for detection of somatic gene mutation. The performance characteristics of this technique has been explored previously, however...

    Authors: Reenu Anne Joy, Sukrishna Kamalasanan Thelakkattusserry, Narendranath Vikkath, Renjitha Bhaskaran, Sajitha Krishnan, Damodaran Vasudevan and Prasanth S. Ariyannur

    Citation: BMC Cancer 2020 20:902

    Content type: Research article

    Published on:

  21. Since the development of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy (IMRT), no prospective study has investigated whether concurrent chemoradiotherapy (SIB-IMRT with 60 Gy) r...

    Authors: Lin-rui Gao, Xin Wang, Weiming Han, Wei Deng, Chen Li, Xiaomin Wang, Yidian Zhao, Wenjie Ni, Xiao Chang, Zongmei Zhou, Lei Deng, Wenqing Wang, Wenyang Liu, Jun Liang, Tao Zhang, Nan Bi…

    Citation: BMC Cancer 2020 20:901

    Content type: Study protocol

    Published on:

  22. The association of neutrophil-lymphocyte ratio (NLR) and CD34 expression level with PSA level, Gleason score, and clinical stage was investigated in patients with prostate cancer. The correlation between NLR a...

    Authors: Yiyang Wang, Xiaofei Dong, Zhaokui Qu, Kang Peng, Xiaolei Sun and Renfu Chen

    Citation: BMC Cancer 2020 20:900

    Content type: Research article

    Published on:

  23. Art therapy may improve the physical, mental, and emotional wellbeing of individuals for a variety of purposes. It remains understudied and underutilized in cancer care. We sought to determine the ability of a...

    Authors: E. B. Elimimian, L. Elson, E. Stone, R. S. Butler, M. Doll, S. Roshon, C. Kondaki, A. Padgett and Z. A. Nahleh

    Citation: BMC Cancer 2020 20:899

    Content type: Research article

    Published on:

  24. Adolescent and young adult (AYA) childhood cancer survivors (CCS) should be empowered to continue their survivor-focused care as they transition into adult medicine. However, the majority of AYA-aged survivors...

    Authors: Karim Thomas Sadak, Milki T. Gemeda, Michelle Grafelman, Joseph P. Neglia, David R. Freyer, Eileen Harwood and Jude Mikal

    Citation: BMC Cancer 2020 20:898

    Content type: Research article

    Published on:

  25. There are controversial results concerning the prognostic implication of TERT promoter mutation in glioma patients concerning MGMT status. In this meta-analysis, we investigated whether there are any interactions...

    Authors: Huy Gia Vuong, Thu Quynh Nguyen, Tam N. M. Ngo, Hoang Cong Nguyen, Kar-Ming Fung and Ian F. Dunn

    Citation: BMC Cancer 2020 20:897

    Content type: Research article

    Published on:

  26. Anticancer compound 3-bromopyruvate (3-BrPA) suppresses cancer cell growth via targeting glycolytic and mitochondrial metabolism. The malignant peripheral nerve sheath tumor (MPNST), a very aggressive, therapy...

    Authors: Christian Linke, Markus Wösle and Anja Harder

    Citation: BMC Cancer 2020 20:896

    Content type: Research article

    Published on:

  27. Increased fucosylation is associated with the chemoresistance phenotype. Meanwhile, fucosyltransferase IV (FUT4) amounts are frequently elevated in lung cancer and may be related to increased chemoresistance.

    Authors: Wei Gao, Jinxiao Liang, Yiru Ye, Jinlan Lu, Tongtong Lin, Na Wang, Jingyin Dong and Jianping Pan

    Citation: BMC Cancer 2020 20:895

    Content type: Research article

    Published on:

  28. The effect of brachytherapy on lymphocytes and cytokines in the tumor microenvironment is unclear. This study aimed to analyze the relationship between the invasion of lymphocytes and cytokines in the tumor mi...

    Authors: Lin Li, Hong Cheng Yue, Yun Wei Han, Wei Liu, Liang Geng Xiong and Jian Wen Zhang

    Citation: BMC Cancer 2020 20:893

    Content type: Research article

    Published on:

  29. The global incidence of thyroid cancer (TC) has risen considerably during the last three decades, while prognosis is generally favorable. We assessed the long-term all-cause mortality in TC survivors compared ...

    Authors: Elena Izkhakov, Lital Keinan-Boker, Micha Barchana, Yacov Shacham, Iris Yaish, Narin N. Carmel Neiderman, Dan M. Fliss, Naftali Stern and Joseph Meyerovitch

    Citation: BMC Cancer 2020 20:892

    Content type: Research article

    Published on:

  30. We have previously found there was a small subpopulation of cells with cancer stem cell-like phenotype ALDH-1 in cervical cancer. Radiotherapy has been applied in most of the cervical cancer. However,the mecha...

    Authors: Tingting Yao, Xueling Weng, Yao Yao, Chunxian Huang, Jing Li, Yongpai Peng, Rongchun Lin and Zhongqiu Lin

    Citation: BMC Cancer 2020 20:891

    Content type: Research article

    Published on:

  31. Extremity liposarcoma represents 25% of extremity soft tissue sarcoma and has a better prognosis than liposarcoma occurring in other anatomic sites. The purpose of this study was to develop two nomograms for p...

    Authors: Lin Ye, Chuan Hu, Cailin Wang, Weiyang Yu, Feijun Liu and Zhenzhong Chen

    Citation: BMC Cancer 2020 20:889

    Content type: Research article

    Published on:

  32. There is growing evidence that pseudogenes may serve as prognostic biomarkers in several cancers. The present study was designed to develop and validate an accurate and robust pseudogene pairs-based signature ...

    Authors: Yajuan Du and Ying Gao

    Citation: BMC Cancer 2020 20:887

    Content type: Research article

    Published on:

  33. Despite obvious advances over the last decades, locally advanced adenocarcinomas of the gastroesophageal junction (GEJ) still carry a dismal prognosis with overall 5-year survival rates of less than 50% even w...

    Authors: Sylvie Lorenzen, Alexander Biederstädt, Ulrich Ronellenfitsch, Christoph Reißfelder, Stefan Mönig, Frederik Wenz, Claudia Pauligk, Martin Walker, Salah-Eddin Al-Batran, Bernhard Haller and Ralf-Dieter Hofheinz

    Citation: BMC Cancer 2020 20:886

    Content type: Study protocol

    Published on:

  34. Identifying and tracking somatic mutations in cell-free DNA (cfDNA) by next-generation sequencing (NGS) has the potential to transform the clinical management of subjects with advanced non-small cell lung canc...

    Authors: John Jiang, Hans-Peter Adams, Maria Lange, Sandra Siemann, Mirjam Feldkamp, Sylvie McNamara, Sebastian Froehler, Stephanie J. Yaung, Lijing Yao, Aarthi Balasubramanyam, Nalin Tikoo, Christine Ju, H. Jost Achenbach, Rainer Krügel and John F. Palma

    Citation: BMC Cancer 2020 20:885

    Content type: Research article

    Published on:

  35. In recent years, there is increasing evidence showing a beneficial outcome (e.g. progression free survival; PFS) after metastases-directed therapy (MDT) with external beam radiotherapy (EBRT) or targeted surge...

    Authors: Bastiaan M. Privé, Marcel J. R. Janssen, Inge M. van Oort, Constantijn H. J. Muselaers, Marianne A. Jonker, Michel de Groot, Niven Mehra, J. Fred Verzijlbergen, Tom W. J. Scheenen, Patrik Zámecnik, Jelle O. Barentsz, Martin Gotthardt, Walter Noordzij, Wouter V. Vogel, Andries M. Bergman, Henk G. van der Poel…

    Citation: BMC Cancer 2020 20:884

    Content type: Study protocol

    Published on:

  36. Myxoid liposarcoma (MLS) has the tendency to metastasize extrapulmonary. Although prognostic factors at the initial diagnosis of MLS have been reported, those at diagnosis of metastasis remain unclear. The pur...

    Authors: Yusuke Shinoda, Eisuke Kobayashi, Hiroshi Kobayashi, Tomoaki Mori, Naofumi Asano, Robert Nakayama, Hideo Morioka, Shintaro Iwata, Tsukasa Yonemoto, Takeshi Ishii, Tohru Hiruma, Akira Kawai and Hirotaka Kawano

    Citation: BMC Cancer 2020 20:883

    Content type: Research article

    Published on:

  37. Cytotoxic chemotherapy can cure advanced germ cell tumors. Nevertheless, cancer treatment may induce cellular senescence and accelerate molecular aging. The aging process implies an increase of cells expressing p...

    Authors: Maria T. Bourlon, Hugo E. Velazquez, Juan Hinojosa, Luis Orozco, Ricardo Rios-Corzo, Guadalupe Lima, Luis Llorente, Diego F. Hernandez-Ramirez, Francisco J. Valentin-Cortez, Irene Medina-Rangel and Yemil Atisha-Fregoso

    Citation: BMC Cancer 2020 20:882

    Content type: Research article

    Published on:

  38. A. oxyphylla extract is known to possess a wide range of pharmacological activites. However, the molecular mechanism of A. oxyphylla and its bioactive compound nootkatone in colorectal cancer is unknown.

    Authors: Eunsu Yoo, Jaehak Lee, Pattawika Lertpatipanpong, Junsun Ryu, Chong-Tai Kim, Eul-Yong Park and Seung Joon Baek

    Citation: BMC Cancer 2020 20:881

    Content type: Research article

    Published on:

  39. Tobacco smoking is associated with a unique mutational signature in the human cancer genome. It is unclear whether tobacco smoking-altered DNA methylations and gene expressions affect smoking-related mutationa...

    Authors: Zhishan Chen, Wanqing Wen, Qiuyin Cai, Jirong Long, Ying Wang, Weiqiang Lin, Xiao-ou Shu, Wei Zheng and Xingyi Guo

    Citation: BMC Cancer 2020 20:880

    Content type: Research article

    Published on:

  40. The nicotinamide nucleotide transhydrogenase antisense RNA 1 (NNT-AS1) is a long non-coding RNA aberrantly expressed in human malignancies. We aimed to analyze available data to evaluate the correlation betwee...

    Authors: Chenghao Zhang, Xiaolei Ren, Zhongyue Liu and Chao Tu

    Citation: BMC Cancer 2020 20:879

    Content type: Research article

    Published on:

  41. Triple-negative breast cancer (TNBC) patients have relatively poor clinical outcomes. A marker predicting the prognosis of patients with TNBC could help guide treatment. Extensive evidence demonstrates that an...

    Authors: Yu-Chen Cai, Hang Yang, Ke-Feng Wang, Tan-Huan Chen, Wen-Qi Jiang and Yan-Xia Shi

    Citation: BMC Cancer 2020 20:878

    Content type: Research article

    Published on:

  42. Currently, adjuvant therapy is not recommended for patients with thoracic esophageal squamous cell cancer (TESCC) after radical surgery, and a proportion of these patients go on to develop locoregional recurre...

    Authors: Xiao Chang, Lei Deng, Wenjie Ni, Chen Li, Weiming Han, Lin-rui Gao, Shijia Wang, Zongmei Zhou, Dongfu Chen, Qinfu Feng, Jun Liang, Nan Bi, Jima Lv, Shugeng Gao, Yousheng Mao, Qi Xue…

    Citation: BMC Cancer 2020 20:877

    Content type: Study protocol

    Published on:

  43. Some evidence has shown that malignant breast tumours have lower electrical impedance than surrounding normal tissues. Electrical impedance could be used as an indicator for breast cancer detection. The purpos...

    Authors: Blanca Murillo-Ortiz, Abraham Hernández-Ramírez, Talia Rivera-Villanueva, David Suárez-García, Mario Murguía-Pérez, Sandra Martínez-Garza, Allyson Rodríguez-Penin, Rosario Romero-Coripuna and Xiomara Midory López-Partida

    Citation: BMC Cancer 2020 20:876

    Content type: Research article

    Published on:

  44. The treatment of choice for advanced non–small cell lung cancer is selected according to the presence of specific alterations. Patients should undergo molecular testing for relevant modifications and the mutat...

    Authors: Luciene Schluckebier, Rosangela Caetano, Osvaldo Ulises Garay, Giuliana T. Montenegro, Marcelo Custodio, Veronica Aran and Carlos Gil Ferreira

    Citation: BMC Cancer 2020 20:875

    Content type: Research article

    Published on:

  45. Langerhans cell histiocytosis (LCH) affects 1–2 in 1,000,000 people. The disease is not associated with increased risk of treatment failure (especially among older children), but appropriate procedures impleme...

    Authors: Anna Raciborska, Katarzyna Bilska, Jadwiga Węcławek-Tompol, Olga Gryniewicz-Kwiatkowska, Małgorzata Hnatko-Kołacz, Joanna Stefanowicz, Anna Pieczonka, Katarzyna Jankowska, Filip Pierelejewski, Tomasz Ociepa, Grażyna Sobol-Milejska, Katarzyna Muszyńska-Rosłan, Olga Michoń, Wanda Badowska, Monika Radwańska and Katarzyna Drabko

    Citation: BMC Cancer 2020 20:874

    Content type: Research article

    Published on:

Featured videos

View featured videos from across the BMC-series journals