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  1. The adverse reactions (ADRs) of targeted therapy were closely associated with treatment response, clinical outcome, quality of life (QoL) of patients with cancer. However, few studies presented the correlation...

    Authors: Ruofei Du, Xin Wang, Lixia Ma, Leon M. Larcher, Han Tang, Huiyue Zhou, Changying Chen and Tao Wang

    Citation: BMC Cancer 2021 21:206

    Content type: Research article

    Published on:

  2. Oral cancer (OC) is usually diagnosed at advanced clinical stages due to its asymptomatic nature and absence of pathognomonic signs in its early development phase. Delayed diagnosis is one of the major causes ...

    Authors: Mayara Martina Abatti Chiamulera, Caroline Biazzolo Zancan, Aline Pertile Remor, Marcos Freitas Cordeiro, Frederico Omar Gleber-Netto and Antuani Rafael Baptistella

    Citation: BMC Cancer 2021 21:205

    Content type: Research article

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  3. With increasing cancer incidence and decreasing cancer mortality, there is a growing need for a valid and culturally adapted tool to measure health-related quality of life in children with cancer. This study v...

    Authors: Hasan Alelayan, Lizhu Liang, Rui Ye, Jiangnan Meng and Xiaoyan Liao

    Citation: BMC Cancer 2021 21:204

    Content type: Research article

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  4. The 2018 International Federation of Gynecology and Obstetrics (FIGO) staging guideline for cervical cancer includes stage IIIC recognized by preoperative radiology (IIIC-r) to state there are lymph nodes meta...

    Authors: E Yang, Shuying Huang, Xuting Ran, Yue Huang and Zhengyu Li

    Citation: BMC Cancer 2021 21:203

    Content type: Research article

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  5. In recent years, emerging studies have demonstrated critical functions and potential clinical applications of long non-coding RNA (lncRNA) in osteosarcoma. To further validate the prognostic value of multiple ...

    Authors: Wenchao Zhang, Xiaolei Ren, Lin Qi, Chenghao Zhang, Chao Tu and Zhihong Li

    Citation: BMC Cancer 2021 21:202

    Content type: Research article

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  6. We assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy.

    Authors: Takeshi Tsutsumi, Kazumasa Komura, Takeshi Hashimoto, Ryu Muraoka, Naoya Satake, Tomohisa Matsunaga, Takuya Tsujino, Yuki Yoshikawa, Tomoaki Takai, Koichiro Minami, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki…

    Citation: BMC Cancer 2021 21:201

    Content type: Research article

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  7. Mesothelin is a 40-kDa glycoprotein that is highly overexpressed in various types of cancers, however molecular mechanism of mesothelin has not been well-known. Amatuximab is a chimeric monoclonal IgG1/k antib...

    Authors: Fumihiko Matsuzawa, Hirofumi Kamachi, Tatsuzo Mizukami, Takahiro Einama, Futoshi Kawamata, Yuki Fujii, Moto Fukai, Nozomi Kobayashi, Yutaka Hatanaka and Akinobu Taketomi

    Citation: BMC Cancer 2021 21:200

    Content type: Research article

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  8. Breast cancer is one of the leading causes of cancer-related deaths in women, and there is a demand in developing an Asian-based genetic profiling database for breast cancer in improving the treatment response...

    Authors: Chi-Cheng Huang, Yi-Fang Tsai, Chun-Yu Liu, Ta-Chung Chao, Pei-Ju Lien, Yen-Shu Lin, Chin-Jung Feng, Jen-Hwey Chiu, Chih-Yi Hsu and Ling-Ming Tseng

    Citation: BMC Cancer 2021 21:199

    Content type: Research article

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  9. The unprecedented efficacy of chimeric antigen receptor T (CAR-T) cell immunotherapy of CD19+ B-cell malignancies has opened a new and useful way for the treatment of malignant tumors. Nonetheless, there are stil...

    Authors: Zhitao Ying, Ting He, Xiaopei Wang, Wen Zheng, Ningjing Lin, Meifeng Tu, Yan Xie, Lingyan Ping, Chen Zhang, Weiping Liu, Lijuan Deng, Meng Wu, Feier Feng, Xin Leng, Tingting Du, Feifei Qi…

    Citation: BMC Cancer 2021 21:198

    Content type: Research article

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  10. Age-adjusted US total pediatric cancer incidence rates (TPCIR) rose 49% 1975–2015 for unknown reasons. Prenatal cannabis exposure has been linked with several pediatric cancers which together comprise the majo...

    Authors: Albert Stuart Reece and Gary Kenneth Hulse

    Citation: BMC Cancer 2021 21:197

    Content type: Research article

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  11. The benefits of adjuvant chemotherapy for elderly patients with gastric cancer (GC) remain unknown because elderly patients are underrepresented in most clinical trials. This study aimed to evaluate the effect...

    Authors: Yanrui Liang, Liying Zhao, Hao Chen, Tian Lin, Tao Chen, Mingli Zhao, Yanfeng Hu, Jiang Yu, Hao Liu and Guoxin Li

    Citation: BMC Cancer 2021 21:196

    Content type: Research article

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  12. Activation of autophagy flux contributed to resistance of breast cancer (BC) cells to current chemotherapeutic drugs, which seriously limited their therapeutic efficacy and facilitated BC recurrence in clinic....

    Authors: Libo Yu, Qingtao Shi, Yan Jin, Zhixin Liu, Jiaxin Li and Wenzhou Sun

    Citation: BMC Cancer 2021 21:195

    Content type: Research article

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  13. Multiple common variants identified by genome-wide association studies have shown limited evidence of the risk of breast cancer in Chinese individuals. In this study, we aimed to uncover the relationship betwe...

    Authors: Feng Zhao, Zhixiang Hao, Yanan Zhong, Yinxue Xu, Meng Guo, Bei Zhang, Xiaoxing Yin, Ying Li and Xueyan Zhou

    Citation: BMC Cancer 2021 21:194

    Content type: Research article

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  14. KRAS is the most frequently mutated oncogene in cancer, however efforts to develop targeted therapies have been largely unsuccessful. Recently, two small-molecule inhibitors, AMG 510 and MRTX849, have shown promi...

    Authors: Luiz Henrique Araujo, Bianca Mendes Souza, Laura Rabelo Leite, Sabrina A. F. Parma, Natália P. Lopes, Frederico S. V. Malta and Maíra C. M. Freire

    Citation: BMC Cancer 2021 21:193

    Content type: Research article

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  15. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Athanasios Tampakis, Ekaterini-Christina Tampaki, Afrodite Nonni, Ioannis D. Kostakis, Alberto Posabella, Konstantinos Kontzoglou, Markus von Flüe, Evangelos Felekouras, Gregory Kouraklis and Nikolaos Nikiteas

    Citation: BMC Cancer 2021 21:191

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2021 21:153

  16. Genome-wide association studies (GWAS) have identified multiple common CRC-related (colorectal cancer) SNPs (single nucleotide polymorphisms) including the Cadherin 1(CDH1) rs9929218 may act by increasing the ...

    Authors: Huiyan Wang, Dongying Gu, Miao Yu, Yanjun Hu, Zhe Chen, Xinying Huo, Tao Yu, Jinfei Chen and Yang Zheng

    Citation: BMC Cancer 2021 21:190

    Content type: Research article

    Published on:

  17. The present study aims to evaluate the efficacy and safety of apatinib monotherapy or combination therapy for patients with advanced or recurrent biliary tract cancer (BTC).

    Authors: Caiyun Nie, Huifang Lv, Yishu Xing, Beibei Chen, Weifeng Xu, Jianzheng Wang and Xiaobing Chen

    Citation: BMC Cancer 2021 21:189

    Content type: Research article

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  18. Gastric outlet obstruction (GOO) is a late complication of advanced gastric cancer, and it is controversial how to select the therapeutic strategies: gastrojejunostomy and palliative gastrectomy? Therefore, th...

    Authors: Xiao-Jiang Chen, Guo-Ming Chen, Yi-Cheng Wei, Hong Yu, Xi-Cheng Wang, Zhou-Kai Zhao, Tian-Qi Luo, Run-Cong Nie and Zhi-Wei Zhou

    Citation: BMC Cancer 2021 21:188

    Content type: Research article

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  19. Super-enhancer-associated long noncoding RNAs (SE-lncRNAs) have been reported to play essential roles in tumorigenesis, but the fundamental mechanism of SE-lncRNAs in colorectal cancer (CRC) remains largely un...

    Authors: Linping Yan, Huanhuan Chen, Li Tang, Pan Jiang and Feng Yan

    Citation: BMC Cancer 2021 21:187

    Content type: Research article

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  20. Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2) is a microtubule associated protein that functions in mitotic spindle assembly. TPX2 also localizes to the nucleus where it functions in DNA damage r...

    Authors: Daniel R. Matson, Ryan A. Denu, Lauren M. Zasadil, Mark E. Burkard, Beth A. Weaver, Christopher Flynn and P. Todd Stukenberg

    Citation: BMC Cancer 2021 21:186

    Content type: Research article

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  21. The growth factor progranulin has been implicated in numerous biological processes such as wound healing, inflammation and progressive tumorigenesis. Both progranulin and its receptor sortilin are known to be ...

    Authors: Karoline Berger, Sara Rhost, Svanheiður Rafnsdóttir, Éamon Hughes, Ylva Magnusson, Maria Ekholm, Olle Stål, Lisa Rydén and Göran Landberg

    Citation: BMC Cancer 2021 21:185

    Content type: Research article

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  22. Establishing diagnostic and prognostic biomarkers of primary central nervous system lymphoma (PCNSL) is a challenge. This study evaluated the value of dynamic interleukin (IL)-10 cerebrospinal fluid (CSF) conc...

    Authors: Yan Zhang, Dongmei Zou, Jingjing Yin, Li Zhang, Xiao Zhang, Wei Wang, Meifen Zhang, Daobin Zhou and Wei Zhang

    Citation: BMC Cancer 2021 21:183

    Content type: Research article

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  23. Bone-targeted agents (BTAs) are widely used in the management of patients with bone metastases from solid tumors. Knowledge of the impact of their routine care use on patient-reported pain and bone pain-relate...

    Authors: Karin Ribi, Beat Thürlimann, Corinne Schär, Daniel Dietrich, Richard Cathomas, Ursina Zürrer-Härdi, Thomas von Briel, Sandro Anchisi, Pierre Bohanes, Veronika Blum, Philippe von Burg, Meinrad Mannhart, Clemens B. Caspar, Roger von Moos and Michael Mark

    Citation: BMC Cancer 2021 21:182

    Content type: Research article

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  24. Mutation analysis using next-generation sequencing highlights the features of tumors with somatic alterations. However, the mutation profile of double cancer remains unclear. Here, we analyzed tumors derived f...

    Authors: Keiichi Hatakeyama, Takeshi Nagashima, Akifumi Notsu, Keiichi Ohshima, Sumiko Ohnami, Shumpei Ohnami, Yuji Shimoda, Akane Naruoka, Koji Maruyama, Akira Iizuka, Tadashi Ashizawa, Hirotsugu Kenmotsu, Tohru Mochizuki, Kenichi Urakami, Yasuto Akiyama and Ken Yamaguchi

    Citation: BMC Cancer 2021 21:181

    Content type: Research article

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  25. Aberrant activation of the Wnt/β-catenin signaling pathway is one of the most frequent abnormalities in human cancer, including colorectal cancer (CRC). Previous studies revealed pivotal functions of WNT famil...

    Authors: Shuai Jiang, Qiwen Li, Yimin Liu, Huimin Zhang, Qianyu Wang, Yu Chen, Xiaoyang Shi, Jun Li, Hailing Zhang, Yi Zhang, Dongqing Xia, Man Wu, Jiajia Lin, Chenglin Zhang, Suhua Pang, Jiamin Jiang…

    Citation: BMC Cancer 2021 21:180

    Content type: Research article

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  26. The management of unresectable locally advanced colon cancer (LACC) remains controversial, as resection is not feasible. The goal of this study was to evaluate the treatment outcomes and toxicity of neoadjuvan...

    Authors: Yan Yuan, Wei-Wei Xiao, Wei-Hao Xie, Pei-Qiang Cai, Qiao-Xuan Wang, Hui Chang, Bao-Qing Chen, Wen-Hao Zhou, Zhi-Fan Zeng, Xiao-Jun Wu, Qing Liu, Li-Ren Li, Rong Zhang and Yuan-Hong Gao

    Citation: BMC Cancer 2021 21:179

    Content type: Research article

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  27. Early detection and diagnosis of parotid gland cancer (PGC) are essential to improve clinical outcomes, because Tumor-Node-Metastasis stage at diagnosis is a very strong indicator of prognosis in PGC. Neverthe...

    Authors: Sung Yong Choi, Eunkyu Lee, Eunhye Kim, Man Ki Chung, Young-Ik Son, Chung-Hwan Baek and Han-Sin Jeong

    Citation: BMC Cancer 2021 21:178

    Content type: Research article

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  28. Transplantation-related mortality (TRM) is a major obstacle in allogeneic hematopoietic cell transplantation (allo-HCT). Approximately 60–80% of TRM occurs early, within 100 days of transplantation.

    Authors: Seom Gim Kong, Seri Jeong, Sangjin Lee, Jee-Yeong Jeong, Da Jung Kim and Ho Sup Lee

    Citation: BMC Cancer 2021 21:177

    Content type: Research article

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  29. Cisplatin (CDDP) significantly prolongs survival in various cancers, but many patients also develop resistance that results in treatment failure. Thus, this study aimed to elucidate the underlying mechanisms b...

    Authors: Jing Guo, Kiyotoshi Satoh, Sho Tabata, Masaru Mori, Masaru Tomita and Tomoyoshi Soga

    Citation: BMC Cancer 2021 21:174

    Content type: Research article

    Published on:

  30. The standard to ensure utmost cancer treatment is a prerequisite in national cancer plans for comprehensive cancer centers (CCCs) and ensured through multidisciplinary tumor boards (MTBs). Despite these being ...

    Authors: Monika Engelhardt, Gabriele Ihorst, Martin Schumacher, Michael Rassner, Laura Gengenbach, Mandy Möller, Khalid Shoumariyeh, Jakob Neubauer, Juliane Farthmann, Georg Herget and Ralph Wäsch

    Citation: BMC Cancer 2021 21:173

    Content type: Correspondence

    Published on:

    The original article was published in BMC Cancer 2020 20:355

  31. Colibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli strains harboring the pks island. Human and animal studies have shown that colib...

    Authors: Manon Oliero, Annie Calvé, Gabriela Fragoso, Thibault Cuisiniere, Roy Hajjar, Ulrich Dobrindt and Manuela M. Santos

    Citation: BMC Cancer 2021 21:172

    Content type: Research article

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  32. There is uncertainty in the literature about preserving the left colic artery (LCA) during low anterior resection for rectal cancer. We analyzed the effect of preserving the LCA on long-term oncological outcomes.

    Authors: Yuwen Luo, Rongjiang Li, Deqing Wu, Jun Zeng, Junjiang Wang, Xianzhe Chen, Chengzhi Huang, Yong Li and Xueqing Yao

    Citation: BMC Cancer 2021 21:171

    Content type: Research article

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  33. The concept of personalized therapy has been proven to be a promising approach. A popular technique is to utilize gold nanoparticles (AuNPs) as drug delivery vectors for cytotoxic drugs and small molecule inhi...

    Authors: Hend M. Abdel Hamid, Zeinab E. Darwish, Sahar M. Elsheikh, Ghada M. Mourad, Hanaa M. Donia and Marwa M. Afifi

    Citation: BMC Cancer 2021 21:170

    Content type: Research article

    Published on:

  34. Numerous studies emphasize the positive effects of physical activity on health and well-being in cancer patients. The effects of physical activity on the working lives of cancer patients have received less att...

    Authors: Rikke Rosbjerg, Robert Zachariae, Dorte Gilså Hansen, Inger Hoejris, Saskia Duijts, Nina Lykkegaard Gehr, Irene Dyhrberg Andersen and Merete Labriola

    Citation: BMC Cancer 2021 21:169

    Content type: Research article

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  35. The prognositc factors in patient with invasive cribriform carcinoma (ICC) of breast is still remain controversal. The study aims to establish a nomogram to predict the survival outcomes in patients with ICC b...

    Authors: Jiameng Liu, Xiaobin Zheng, Zhonghua Han, Shunguo Lin, Hui Han and Chunsen Xu

    Citation: BMC Cancer 2021 21:168

    Content type: Research article

    Published on:

  36. Radiotherapy is the mainstay of brain metastasis (BM) management. Radiation necrosis (RN) is a serious complication of radiotherapy. Bevacizumab (BV), an anti-vascular endothelial growth factor monoclonal anti...

    Authors: Muhammad Khan, Zhihong Zhao, Sumbal Arooj and Guixiang Liao

    Citation: BMC Cancer 2021 21:167

    Content type: Research article

    Published on:

  37. Although fat necrosis is a minor postoperative complication after breast reconstruction, occasionally it mimics to tumor recurrence in patients with breast cancer. Therefore, the surgeon should distinguish bet...

    Authors: Jeeyeon Lee, Ho Yong Park, Wan Wook Kim, Jeong Ju Lee, Hee Jung Keum, Jung Dug Yang, Jeong Woo Lee, Joon Seok Lee and Jin Hyang Jung

    Citation: BMC Cancer 2021 21:166

    Content type: Research article

    Published on:

  38. The current management guidelines recommend that patients with borderline resectable pancreatic adenocarcinoma (BRPC) should initially receive neoadjuvant chemotherapy. The addition of advanced radiation thera...

    Authors: Salvatore Paiella, Giuseppe Malleo, Nicola Simoni, Renato Micera, Stefania Guariglia, Carlo Cavedon, Giovanni Marchegiani, Alessandro Esposito, Luca Landoni, Luca Casetti, Massimiliano Tuveri, Michele Milella, Erica Secchettin, Gessica Manzini, Chiara Bovo, Matteo De Pastena…

    Citation: BMC Cancer 2021 21:165

    Content type: Study protocol

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  39. Activating Gαq signalling mutations are considered an early event in the development of uveal melanoma. Whereas most tumours harbour a mutation in GNAQ or GNA11, CYSLTR2 (encoding G-protein coupled receptor CysLT

    Authors: Rogier J. Nell, Nino V. Menger, Mieke Versluis, Gregorius P. M. Luyten, Robert M. Verdijk, Michele C. Madigan, Martine J. Jager and Pieter A. van der Velden

    Citation: BMC Cancer 2021 21:164

    Content type: Research article

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  40. Ovarian cancer (OC) is a life-threatening gynecological malignancy where dysregulation of microRNAs (miRNAs) is frequently implicated. This study focuses on the function of miR-545 on OC development and the mo...

    Authors: Hailing Zhang, Ke Zhang, Zhen Xu, Zhilong Chen, Qian Wang, Chenyang Wang and Jinquan Cui

    Citation: BMC Cancer 2021 21:163

    Content type: Research article

    Published on:

  41. Urothelial carcinoma (UC) is the most common genitourinary malignancy in China. In this study, we surveyed the genomic features in Chinese UC patients and investigated the concordance of genetic alterations be...

    Authors: Bo Yang, Xiao Zhao, Chong Wan, Xin Ma, Shaoxi Niu, Aitao Guo, Jieli Wang, Jinliang Wang, Decong Sun and Shunchang Jiao

    Citation: BMC Cancer 2021 21:162

    Content type: Research article

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  42. Early screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone metastasis. We aimed to identify serum lncRNA as a prediction biomarker in H...

    Authors: Li Zhang, Hao Niu, Ping Yang, Jie Ma, Bao-Ying Yuan, Zhao-Chong Zeng and Zuo-Lin Xiang

    Citation: BMC Cancer 2021 21:161

    Content type: Research article

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  43. BCL2 associated Athano-Gene 1 (BAG1) has been described to be involved in the development and progression of cancer. But the role of BAG1 in kidney renal clear cell carcinoma (KIRC) has remained largely unknown.

    Authors: Hongrong Wu, Minjing Liu, Yuejun He, Guozhao Meng, Wanbei Guo and Qiong Guo

    Citation: BMC Cancer 2021 21:160

    Content type: Research article

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  44. Advanced lung cancer patients face significant physical and psychological burden leading to reduced physical function and quality of life. Separately, physical activity, nutrition, and palliative symptom manag...

    Authors: Manuel Ester, S. Nicole Culos-Reed, Amane Abdul-Razzak, Julia T. Daun, Delaney Duchek, George Francis, Gwyn Bebb, Jennifer Black, Audra Arlain, Chelsia Gillis, Lyle Galloway and Lauren C. Capozzi

    Citation: BMC Cancer 2021 21:159

    Content type: Research article

    Published on:

  45. Uterine serous carcinoma (USC) is an aggressive type of endometrial cancer that accounts for up to 40% of endometrial cancer deaths, creating an urgent need for prognostic biomarkers.

    Authors: Hui Chen, Lingjun Li, Ping Qin, Hanzhen Xiong, Ruichao Chen, Minfen Zhang and Qingping Jiang

    Citation: BMC Cancer 2021 21:154

    Content type: Research article

    Published on:

  46. The goal of this study is to disclose the clinically significant genomic alterations in the Chinese and Western patients with intrahepatic cholangiocarcinoma.

    Authors: Shifeng Xu, Yuan Guo, Yanwu Zeng, Zhijian Song, Xiaodan Zhu, Ning Fan, Zhilei Zhang, Guibing Ren, Yunjin Zang and Wei Rao

    Citation: BMC Cancer 2021 21:152

    Content type: Research article

    Published on:

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