Following publication of the original article [1], it was reported that the legend for Fig. 1 was incomplete. The complete figure legend is:
Authors: Aleksandar Sekulic, Michael R. Migden, Nicole Basset-Seguin, Claus Garbe, Anja Gesierich, Christopher D. Lao, Chris Miller, Laurent Mortier, Dedee F. Murrell, Omid Hamid, Jorge F. Quevedo, Jeannie Hou, Edward McKenna, Natalie Dimier, Sarah Williams, Dirk Schadendorf…
Worldwide, breast cancer is the main cause of cancer mortality in women. Most cases originate in mammary ductal cells that produce the nipple aspirate fluid (NAF). In cancer patients, this secretome contains p...
Authors: Giselle Villa Flor Brunoro, Paulo Costa Carvalho, Valmir C. Barbosa, Dante Pagnoncelli, Claudia Vitória De Moura Gallo, Jonas Perales, René Peiman Zahedi, Richard Hemmi Valente and Ana Gisele da Costa Neves-Ferreira
Our aim of the study is to investigate the feasibility of preoperative prediction for hepatocellular carcinoma (HCC) histological grading using gadoxetic acid-enhanced magnetic resonance imaging (MRI).
Authors: Kun Huang, Zhi Dong, Huasong Cai, Mengqi Huang, Zhenpeng Peng, Ling Xu, Yingmei Jia, Chenyu Song, Zi-Ping Li and Shi-Ting Feng
Hepatoma arterial-embolization prognostic (HAP) score and its modifications (modified HAP [mHAP] and mHAP-II), consisting of some or all of the following factors of tumor size, number, alpha-fetoprotein, bilir...
Authors: Yehyun Park, Beom Kyung Kim, Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han, Jong Eun Yeon, Kwan Soo Byun, Hye Soo Kim, Ji Hoon Kim and Seung Up Kim
Brain metastases (BM) are rarely reported in patients with neuroendocrine carcinoma (NEC) of non-lung origin and neuroendocrine tumors (NET) of the gastroenteropancreatic (GEP) or bronchopulmonary system. Howe...
Authors: Sebastian Krug, Freya Teupe, Patrick Michl, Thomas M. Gress and Anja Rinke
Phase I trials aim to identify the recommended dose for further development. Health-related quality of life (HRQoL) could be a complement to the usual National Cancer Institute Common Terminology Criteria for ...
Authors: Frédéric Fiteni, Isabelle Le Ray, Ahmad Ousmen, Nicolas Isambert, Amélie Anota and Franck Bonnetain
In clinical practice, the detection of biomarkers is mostly based on primary tumors for its convenience in acquisition. However, immune checkpoints may express differently between primary and metastatic tumor....
Nonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). ...
Micafungin is a well-tolerated and effective prophylactic antifungal agent used in hematologic diseases. In this prospective trial, we evaluated the efficacy and safety of prophylactic micafungin during first ...
Authors: Hyunkyung Park, Jeonghwan Youk, Dong-Yeop Shin, Junshik Hong, Inho Kim, Nam Joong Kim, Jeong-Ok Lee, Soo-Mee Bang, Sung-Soo Yoon, Wan Beom Park and Youngil Koh
Osteosarcoma is the most common malignant bone tumor in children. Survival remains poor among histologically poor responders, and there is a need to identify them at diagnosis to avoid delivering ineffective t...
Authors: Krithika Bhuvaneshwar, Michael Harris, Yuriy Gusev, Subha Madhavan, Ramaswamy Iyer, Thierry Vilboux, John Deeken, Elizabeth Yang and Sadhna Shankar
Glucocorticoid receptor (GR) activation has been associated with breast cancer cell survival in vitro. Glucocorticoid (GC)-dependent protection against tumor necrosis factor (TNF)-induced cell death has been w...
Authors: Irma B. Mitre-Aguilar, Tonatiuh Barrios-Garcia, Victor M. Ruiz-Lopez, Alberto J. Cabrera-Quintero, Nancy R. Mejia-Dominguez, Jose L. Ventura-Gallegos, Daniel Moreno-Mitre, Alejandro Aranda-Gutierrez, Janini Mejia-Rangel, Alma R. Escalona-Guzman, Yanin Chavarri-Guerra, Alfonso Leon-Del-Rio and Alejandro Zentella-Dehesa
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) that often affects men over the age of 60. Systemic metastasis of MCL to eyes is rare and intraocular involvement is even rare...
Authors: Minghang Pei, Chan Zhao, Fei Gao and Meifen Zhang
Head and neck squamous cell carcinoma (HNSCC) represents one of the most common malignancies worldwide with a high mortality rate mainly due to lack of early detection markers, frequent association with metast...
Authors: Subhayan Sur, Hiroshi Nakanishi, Robert Steele and Ratna B. Ray
Locally advanced or metastatic non-small cell lung cancer (NSCLC) that has progressed after first-line treatment has a poor prognosis. Recent randomized clinical trials (RCTs) have demonstrated survival benefi...
Authors: Adrian D. Vickers, Katherine B. Winfree, Gebra Cuyun Carter, Urpo Kiiskinen, Min-Hua Jen, Donald Stull, James A. Kaye and David P. Carbone
High risk human papillomaviruses (HPV) plays important roles in the development of cervical cancer, a number of other anogenital cancer and they are increasingly found in oropharyngeal squamous cell carcinoma ...
Authors: Ge Gao, Jintu Wang, Jan L. Kasperbauer, Nicole M. Tombers, Fei Teng, Honglan Gou, Yonggang Zhao, Zhenhong Bao and David I. Smith
Optimising breast cancer treatment remains a challenge. Resistance to therapy is a major problem in both ER- and ER+ breast cancer. Tumour recurrence after chemotherapy and/or targeted therapy leads to more ag...
Authors: Lana McClements, Stephanie Annett, Anita Yakkundi, Martin O’Rourke, Andrea Valentine, Nermeen Moustafa, Abdelrahim Alqudah, Bruno M. Simões, Fiona Furlong, Amy Short, Stuart A. McIntosh, Helen O. McCarthy, Robert B. Clarke and Tracy Robson
Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias i...
The exact signalling mechanism of the mTOR complex remains a subject of constant debate, even with some evidence that amino acids participate in the same pathway as used for insulin signalling during protein s...
Authors: Bread Cruz, André Oliveira, Gislaine Ventrucci and Maria Cristina Cintra Gomes-Marcondes
Extrahepatic cholangiocarcinoma (ECC) has become one of the most rapidly increasing malignancies in China during recent decades. The relationship between tobacco exposure and ECC epidemics is unclear; this stu...
Authors: Lei Hou, Jingmei Jiang, Boqi Liu, Wei Han, Yanping Wu, Xiaonong Zou, Fang Xue, Yuanli Chen, Biao Zhang, Haiyu Pang, Yuyan Wang, Zixing Wang, Yaoda Hu and Junyao Li
Hematopoietic stem cell transplantation (HSCT) remains an important therapeutic option for many hematologic malignancies. Bone marrow harvesting from an appropriate donor must be conducted for hematopoietic st...
Authors: Tae-Woo Nam, Hyun-Min Oh, Jae-Eun Lee, Ju-Hyun Kim, Jong-moon Hwang, Eunhee Park and Tae-Du Jung
Prostate cancer is the most common form of cancer in males and accounts for high cancer related deaths. Therapeutic advancement in prostate cancer has not been able to reduce the mortality burden of prostate c...
Authors: Ankit Tiwari, Bratati Mukherjee, Md. Khurshidul Hassan, Niharika Pattanaik, Archita Mohanty Jaiswal and Manjusha Dixit
Background: Benign breast lesions are the most common diseases in adult women, which have been treated with minimally invasive therapies in recent years. Little is known about the feasibility of Microwave abla...
Authors: Wei Zhang, Zhan-Qiang Jin, Masoud Baikpour, Jian-Min Li, Hui Zhang, Ting Liang, Xiao-Ming Pan and Wen He
This study protocol describes the clinical trial of the Fex-Can intervention, a web-based self-help program targeting sexual dysfunction and fertility-related distress. The psycho-educational intervention has ...
Authors: C. Lampic, L. Ljungman, C. Micaux Obol, L. E. Eriksson and L. Wettergren
Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. The PI3K cascade is one of the major signaling pathways underlying HCC development and progression. Activating mutations of...
Authors: Hui Cao, Zhong Xu, Jingxiao Wang, Antonio Cigliano, Maria G. Pilo, Silvia Ribback, Shu Zhang, Yu Qiao, Li Che, Rosa M. Pascale, Diego F. Calvisi and Xin Chen
The surgical treatment of breast cancer has been associated with negative consequences for patients’ body image, sexual functioning, mental health, and social adjustment. Recent advances in the surgical approa...
Authors: Jennifer Gass, Sunny Mitchell and Michael Hanna
Outcomes of patients with ovarian high-grade serous carcinoma (HGSC) treated with neoadjuvant chemotherapy (NAC) have been widely studied, but there is limited information on the outcomes of patients with non-...
Authors: Young Shin Chung, Sang-Yoon Park, Jung-Yun Lee, Jeong-Yeol Park, Jeong-Won Lee, Hee Seung Kim, Dong Soo Suh, Yun Hwan Kim, Jong-Min Lee, Miseon Kim, Min Chul Choi, Seung-Hyuk Shim, Keun Ho Lee, Taejong Song, Jin Hwa Hong, Won Moo Lee…
Breast, colorectal, and prostate cancer survivors are at increased risk for late and long-term effects post-treatment. The post-treatment phase of care is often poorly coordinated and survivors navigate follow...
Authors: Stacy N. Davis, Denalee M. O’Malley, Alicja Bator, Pamela Ohman-Strickland, Lynn Clemow, Jeanne M. Ferrante, Benjamin F. Crabtree, Suzanne M. Miller, Patricia Findley and Shawna V. Hudson
Enzalutamide is an oral androgen receptor targeted agent that has been shown to improve survival in PREVAIL trials and has been approved for patients with chemo-naïve metastatic castration-resistant prostate c...
Prognoses of most adult Hodgkin lymphoma (HL) patients are excellent; most of them can achieve permanent remission that can be considered cured. However, many are under-treated or over-treated by standard mode...
Authors: Shing Fung Lee, Ting Ying Ng and Devon Spika
Incidence of renal dysfunction and risks of progression to end-stage renal disease (ESRD) were reported higher in upper urinary tract urothelial carcinoma (UTUC) than in renal cell carcinoma (RCC) patients aft...
Abscopal effect is the out-of-field response to localized irradiation therapy that results in systemic antitumorigenic effects such as the regression of a tumor distant from the target site.
Authors: Aoi Kuroda, Takaya Tabuchi, Eri Iwami, Kotaro Sasahara, Tatsu Matsuzaki, Takahiro Nakajima, Yuki Tsutsumi, Keisuke Eguchi and Takeshi Terashima
Here we describe the treatments and prognosis for metachronous metastases from gastroenteropancreatic neuroendocrine tumors (GEP-NETs) after initial R0 surgical resection at a large center in China.
Authors: Yang Lv, Xu Han, Xue-Feng Xu, Yuan Ji, Yu-Hong Zhou, Hui-Chuan Sun, Jian Zhou, Jia Fan, Wen-Hui Lou and Cheng Huang
Our aim was to determine the epidemiology and recent changes in the trends of non-functional pancreatic neuroendocrine tumours (NF-pNETs) at the population level. In addition, we explored the risk factors that...
Authors: Junjun Wu, Chi Sun, Enliang Li, Jiakun Wang, Xianping He, Rongfa Yuan, Chenghao Yi, Wenjun Liao and Linquan Wu
Visceral organ metastasis is associated with poor survival outcomes in terms of metastasis free- and overall survival in breast carcinomas. Identification of a gene expression profile in tumours that selects a...
Authors: C. D. Savci-Heijink, H. Halfwerk, J. Koster, H. M. Horlings and M. J. van de Vijver
The treatment of patients with glioma depended on the nature of the lesion and on histological grade of the tumor. Positron emission tomography (PET) using 13N-ammonia (NH3), 11C-methionine (MET) and 18F-fluorode...
Authors: Qiao He, Linqi Zhang, Bing Zhang, Xinchong Shi, Chang Yi and Xiangsong Zhang
Non-muscular invasive bladder cancer (NMIBC) has a high risk of recurrence. As androgen receptor (AR) reportedly affects bladder cancer, we assessed the correlation between NMIBC recurrence and tumor AR expressio...
Authors: Masato Yasui, Takashi Kawahara, Koji Izumi, Masahiro Yao, Yukari Ishiguro, Hitoshi Ishiguro, Hiroji Uemura and Yasuhide Miyoshi
Decisions made in multidisciplinary tumor conferences (MTC) that consider patient preferences result in better patient outcomes. Furthermore, it has been shown that in some breast cancer centers in Germany, pa...
Authors: Christian Heuser, Annika Diekmann, Christoph Kowalski, Anna Enders, Rupert Conrad, Holger Pfaff, Lena Ansmann and Nicole Ernstmann
In this study, the influence of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) on the prognosis of giant cell tumor (GCT) of the extremities were investigated.
Authors: Zhenhao Chen, Guanglei Zhao, Feiyan Chen, Jun Xia and Li Jiang
Cancer cells evolve and constitute heterogeneous populations that fluctuate in space and time and are subjected to selection generating intratumor heterogeneity. This phenomenon is determined by the acquisitio...
Authors: Emanuel M. Campoy, María T. Branham, Luis S. Mayorga and María Roqué
Recurrences are reported in 70% of all patients after resection of colorectal liver metastases (CRLM), in which half are confined to the liver. Adjuvant hepatic arterial infusion pump (HAIP) chemotherapy aims ...
Authors: F. E. Buisman, M. Y. V. Homs, D. J. Grünhagen, W. F. Filipe, R. J. Bennink, M. G. H. Besselink, I. H. M. Borel Rinkes, R. C. G. Bruijnen, A. Cercek, M. I. D’Angelica, O. M. van Delden, M. L. Donswijk, L. van Doorn, P. G. Doornebosch, J. Emmering, J. I. Erdmann…
Breast cancer (BC) displays striking genetic, epigenetic and phenotypic diversity. N6-methyladenosine (m6A) in mRNA has emerged as a crucial epitranscriptomic modification that controls cancer self-renewal and ce...
Authors: Lianpin Wu, Dengying Wu, Jinfeng Ning, Wei Liu and Donghong Zhang
For progressive metastatic medullary thyroid carcinoma (MTC), the available treatment options with tyrosine kinase inhibitors result in grade 3–4 adverse events in a large number of patients. Peptide Receptor ...
Authors: Carolien M. Beukhof, Tessa Brabander, Francien H. van Nederveen, Marie-Louise F. van Velthuysen, Yolanda B. de Rijke, Leo J. Hofland, Gaston J. H. Franssen, Lideke A. C. Fröberg, Boen L. R. Kam, W. Edward Visser, Wouter W. de Herder and Robin P. Peeters
We are reporting a rare case of MUTYH-associated polyposis, a colorectal cancer hereditary syndrome, diagnosticated after an intussusception. Colorectal cancer is an important cause of cancer related mortality...
Authors: Gustavo Heluani Antunes de Mesquita, Bárbara Justo Carvalho, Kayo Augusto de Almeida Medeiros, Fernanda Nii, Diego Ramos Martines, Leonardo Zumerkorn Pipek, Yuri Justi Jardim, Daniel Reis Waisberg, Marcos Takeo Obara, Roberta Sitnik, Alberto Meyer and Cristóvão Luis Pitangueiras Mangueira
Multiple trials have attempted to assess the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in osteosarcoma with results remaining inconclusive. This ...
Authors: Fanxiao Liu, Qingyu Zhang, Dongsheng Zhou and Jinlei Dong
MYC is a heterogeneously expressed transcription factor that plays a multifunctional role in many biological processes such as cell proliferation and differentiation. It is also associated with many types of c...
Authors: Karsten Kleo, Lora Dimitrova, Elisabeth Oker, Nancy Tomaszewski, Erika Berg, Franziska Taruttis, Julia C. Engelmann, Philipp Schwarzfischer, Jörg Reinders, Rainer Spang, Wolfram Gronwald, Peter J. Oefner and Michael Hummel
The purpose of this review is to update previously published reviews on exercise programming in exercise trials in prostate cancer survivors. We evaluated: 1) the application of the principles of exercise trai...
Authors: Sarah E. Neil-Sztramko, Mary E. Medysky, Kristin L. Campbell, Kelcey A. Bland and Kerri M. Winters-Stone
Oesophageal cancer has a high metastatic potential and poor prognosis, with a significant risk of recurrence after radical resection. However, resected pancreatic metastasis from oesophageal cancer is rare.
Authors: Wataru Koizumi, Minoru Kitago, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Go Oshima, Shutaro Hori, Kenta Inomata, Hirofumi Kawakubo, Miho Kawaida and Yuko Kitagawa
Despite the previously suggested role of Neudesin in tumorigenesis and its potential as a novel target for the treatment of cancers, its prognostic value has never been examined. Thus, the aim of the study was...
Authors: Olga M. Koper-Lenkiewicz, Joanna Kamińska, Anna Milewska, Karol Sawicki, Marek Jadeszko, Zenon Mariak, Joanna Reszeć, Violetta Dymicka-Piekarska and Joanna Matowicka-Karna
The differentiation between pancreatic head cancer (PHC) and distal cholangiocarcinoma (DCC) can be challenging because of their anatomical and histopathological similarity. This is an important problem, becau...
Regulatory immune cells may modulate the lymphoma microenvironment and are of great interest due to the increasing prevalence of treatment with immunotherapies in lymphoma patients. The aim was to explore the ...
Authors: R-M Amini, G. Enblad, P. Hollander, S. Laszlo, E. Eriksson, K. Ayoola Gustafsson, A. Loskog and I. Thörn
