Articles

Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma

Although many intratumoral biomarkers have been reported to predict clear cell renal cell carcinoma (ccRCC) patient prognosis, combining intratumoral and clinical indicators could predict ccRCC prognosis more ...

Authors: Chao Wang, Keqin Dong, Yuning Wang, Guang Peng, Xu Song, Yongwei Yu, Pei Shen and Xingang Cui

Dynamic nomograms combining N classification with ratio-based nodal classifications to predict long-term survival for patients with lung adenocarcinoma after surgery: a SEER population-based study

The prognostic roles of three lymph node classifications, number of positive lymph nodes (NPLN), log odds of positive lymph nodes (LODDS), and lymph node ratio (LNR) in lung adenocarcinoma are unclear. We aim ...

Authors: Suyu Wang, Yue Yu, Wenting Xu, Xin Lv, Yufeng Zhang and Meiyun Liu

The frequency of medical reversals in a cross-sectional analysis of high-impact oncology journals, 2009–2018

Identifying ineffective practices that have been used in oncology is important in reducing wasted resources and harm. We sought to examine the prevalence of practices that are being used but have been shown in...

Authors: Alyson Haslam, Jennifer Gill, Tyler Crain, Diana Herrera-Perez, Emerson Y. Chen, Talal Hilal, Myung S. Kim and Vinay Prasad

Resilience and its associated factors in head and neck cancer patients in Pakistan: an analytical cross-sectional study

The study aimed to assess resilience and its associated factors in head and neck cancer patients, post-treatment in a low middle income country (LMIC) such as Pakistan.

Authors: Nida Zahid, Wajeeha Zahid, Wardah Khalid, Iqbal Azam, Mubasher Ikram, Aneesa Hassan, Haissan Iftikar, Shireen Shehzad Bhamani, Adnan Abdul Jabbar, Shabbir Akhtar, Moghira Iqbaluddin Siddiqui, Mohammad Sohail Awan, Nargis Asad and Khabir Ahmad

Modified completely intrafascial radical cysprostatectomy for bladder cancer: a single-center, blinded, controlled study

We have proposed a modified, completely intrafascial radical cysprostatectomy (RC) to treat bladder cancer patients with the aim of preserving the patients’ post-surgical urinary control and erectile function....

Authors: Xiao Wang, Jia Guo, Lei Wang, Min Wang, Xiaodong Weng, Hui Chen and Xiuheng Liu

Clinical application of whole transcriptome sequencing for the classification of patients with acute lymphoblastic leukemia

Considering the clinical and genetic characteristics, acute lymphoblastic leukemia (ALL) is a rather heterogeneous hematological neoplasm for which current standard diagnostics require various analyses encompa...

Authors: Wencke Walter, Rabia Shahswar, Anna Stengel, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach and Claudia Haferlach

Haplotype analysis on correlation between transcription factor 7-like 2 gene polymorphism and breast cancer risk

Up to now, limited researches focused on the association between transcription factor 7-like 2 gene (TF7L2) gene single nucleotide polymorphisms (SNPs) and breast cancer (BC) risk. The aim of this study was to ev...

Authors: Yang Wang, Xiaojuan Men, Yongxue Gu, Huidong Wang and Zhicai Xu

Upregulated NLGN1 predicts poor survival in colorectal cancer

Neuroligin1 (NLGN1) is a main component of excitatory glutamatergic synapses complex and is important for synapse assembly and function. The clinical value of NLGN1 in colorectal cancer (CRC) is not clear.

Authors: Qian Yu, Xiaojie Wang, Yinghong Yang, Pan Chi, Jianping Huang, Shengliang Qiu, Xin Zheng and Xiaowen Chen

Distinct employment interference profiles in patients with breast cancer prior to and for 12 months following surgery

To identify subgroups of female breast cancer patients with distinct self-reported employment interference (EI) profiles and determine which demographic, clinical, and symptom characteristics, and quality of l...

Authors: Raymond Javan Chan, Bruce Cooper, Louisa Gordon, Nicolas Hart, Chia Jie Tan, Bogda Koczwara, Kord M. Kober, Alexandre Chan, Yvette P. Conley, Steven M. Paul and Christine Miaskowski

Correction to: Bridging the research to practice gap: a systematic scoping review of implementation of interventions for cancer-related fatigue management

Authors: Oluwaseyifunmi Andi Agbejule, Nicolas H. Hart, Stuart Ekberg, Bogda Koczwara, Rahul Ladwa, Camilla Simonsen, Elizabeth P. Pinkham and Raymond Javan Chan

Correction to: Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin

Authors: Se-Kyeong Jang, Sung-Eun Hong, Da-Hee Lee, Ji-Young Kim, Ji Yea Kim, Sang-Kyu Ye, Jungil Hong, In-Chul Park and Hyeon-Ok Jin

Secondhand smoke exposure, diabetes, and high BMI are risk factors for uterine cervical cancer: a cross-sectional study from the Korea national health and nutrition examination survey (2010–2018)

Human papilloma virus infection and tobacco smoking are the major risk factors for cervical cancer. There are limited studies searching other risk factors for cervical cancer and the results are not consistent...

Authors: Ji Young Kim, Dae Woo Lee, Min Jeong Kim, Jae Eun Shin, Yeun Joo Shin and Hae Nam Lee

Characterization of newly established Pralatrexate-resistant cell lines and the mechanisms of resistance

Pralatrexate (PDX) is a novel antifolate approved for the treatment of patients with relapsed/refractory peripheral T-cell lymphoma, but some patients exhibit intrinsic resistance or develop acquired resistanc...

Authors: Kana Oiwa, Naoko Hosono, Rie Nishi, Luigi Scotto, Owen A. O’Connor and Takahiro Yamauchi

Salvage surgery for patients with residual/persistent diseases after improper or insufficient treatment of oral squamous cell carcinoma: can we rectify these mistakes?

Patterns of failure after treatment of oral and squamous cell carcinomas (OSCC) are diversified, with recurrences being one of the common causes. A special group of patients are sometimes encountered in the ou...

Authors: Yue He, Zhonglong Liu, Surui Sheng, Weijin Gao, Xiao Tang, Xiaoguang Li and Chunyue Ma

A phase I/II clinical trial on the efficacy and safety of NKT cells combined with gefitinib for advanced EGFR-mutated non-small-cell lung cancer

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, have achieved good efficacy in EGFR mutation-positive non-small-cell lung cancer (NSCLC) patients, but eventual drug ...

Authors: Wanjun Yu, Fei Ye, Xiao Yuan, Yali Ma, Chaoming Mao, Xiaoqin Li, Jian Li, Chunhua Dai, Fenhong Qian, Junrong Li, Xiujuan Fan, Yuepeng Zhou, Deqiang Wang, Zhenhong Guo, Huazhang An, Minghui Zhang…

Quantification of m6A RNA methylation modulators pattern was a potential biomarker for prognosis and associated with tumor immune microenvironment of pancreatic adenocarcinoma

m6A is the most prevalent and abundant form of mRNA modifications and is closely related to tumor proliferation, differentiation, and tumorigenesis. In this study, we try to conduct an effective prediction mod...

Authors: Lianzi Wang, Shubing Zhang, Huimin Li, Yang Xu, Qiang Wu, Jilong Shen, Tao Li and Yuanhong Xu

Prognostic significance of occult lymph node metastases in breast cancer: a meta-analysis

Occult metastases in axillary lymph nodes have been reported to be associated with poor prognosis in patients with breast cancer. However, studies on the prognostic value of occult metastases have shown contro...

Authors: Guixin Wang, Shuhao Zhang, Meiling Wang, Lin Liu, Yaqian Liu, Lianjun Tang, He Bai and Haidong Zhao

Effect of spectral CT on tumor microvascular angiogenesis in renal cell carcinoma

To examine the value of energetic-spectrum computed tomography (spectral CT) quantitative parameters in renal cell carcinoma (RCC) microvascular angiogenesis.

Authors: Bei Zhang, Qiong Wu, Xiang Qiu, Xiaobo Ding, Jin Wang, Jing Li, Pengfei Sun and Xiaohan Hu

Efficacy of osimertinib for preventing leptomeningeal metastasis derived from advanced EGFR-mutated non-small cell lung cancer: a propensity-matched retrospective study

Leptomeningeal metastasis (LM) is a severe complication of advanced non-small cell lung cancer (NSCLC). This retrospective study aimed to investigate the potential use of osimertinib for preventing LM in patie...

Authors: Xia Wang, Jing Cai, Zhimin Zeng and Anwen Liu

Clinical and genetic factors associated with anxiety and depression in breast cancer patients: a cross-sectional study

Despite the progress in assessment and treatment of breast cancer, being diagnosed with it or receiving chemotherapy treatment is still conceived as a traumatic experience. Women develop negative thoughts abou...

Authors: Aline HAJJ, Roula HACHEM, Rita KHOURY, Souheil HALLIT, Bashar ElJEBBAWI, Fady NASR, Fadi EL KARAK, Georges CHAHINE, Joseph KATTAN and Lydia RABBAA KHABBAZ

NR1D1 suppressed the growth of ovarian cancer by abrogating the JAK/STAT3 signaling pathway

Nuclear receptor subfamily 1 group D member 1 (NR1D1), a nuclear receptor associated with a variety of physiological processes, has a low level in ovarian cancer tissues compared with adjacent normal tissues. ...

Authors: Huailin Wang and Yan Fu

Effects of a DVD-delivered randomized controlled physical activity intervention on functional health in cancer survivors

Supervised physical activity interventions improve functional health during cancer survivorship, but remain costly and inaccessible for many. We previously reported on the benefits of a DVD-delivered physical ...

Authors: Elizabeth A. Salerno, Neha P. Gothe, Jason Fanning, Lindsay L. Peterson, Graham A. Colditz and Edward McAuley

Overtreatment in nonmalignant lesions detected in a colorectal cancer screening program: a retrospective cohort study

Although colorectal cancer (CRC) screening programs reduce CRC incidence and mortality, they are associated with risks in healthy subjects. However, the risk of overtreatment and overdiagnosis has not been det...

Authors: Joaquín Cubiella, Antía González, Raquel Almazán, Elena Rodríguez-Camacho, Raquel Zubizarreta and Isabel Peña-Rey Lorenzo

Cancer cell line microarray as a novel screening method for identification of radioresistance biomarkers in head and neck squamous cell carcinoma

Currently, no clinically useful biomarkers for radioresistance are available in head and neck squamous cell carcinoma (HNSCC). This study assesses the usefulness of Cell Line Microarray (CMA) method to enhance...

Authors: Johannes Routila, Karri Suvila, Reidar Grénman, Ilmo Leivo, Jukka Westermarck and Sami Ventelä

Combination chemoradiotherapy with temozolomide, vincristine, and interferon-β might improve outcomes regardless of O6-methyl-guanine-DNA-methyltransferase (MGMT) promoter methylation status in newly glioblastoma

This investigator-initiated, open-label, single-arm, single-institute study was conducted to investigate the effectiveness of induction combination chemoradiotherapy and long-term maintenance therapy with temo...

Authors: Kenichiro Asano, Toshio Fumoto, Masashi Matsuzaka, Seiko Hasegawa, Naoya Suzuki, Kenichi Akasaka, Kosuke Katayama, Akihisa Kamataki, Akira Kurose and Hiroki Ohkuma

Prediction of lymphovascular space invasion using a combination of tenascin-C, cox-2, and PET/CT radiomics in patients with early-stage cervical squamous cell carcinoma

Lymphovascular space invasion is an independent prognostic factor in early-stage cervical cancer. However, there is a lack of non-invasive methods to detect lymphovascular space invasion. Some researchers foun...

Authors: Xiaoran Li, Chen Xu, Yang Yu, Yan Guo and Hongzan Sun

Proteomic analysis identifies deregulated metabolic and oxidative-associated proteins in Italian intrahepatic cholangiocarcinoma patients

Cholangiocarcinoma (CCA) is an aggressive disease with poor prognosis. A molecular classification based on mutational, methylation and transcriptomic features could allow identifying tailored therapies to impr...

Authors: Giuliana Cavalloni, Caterina Peraldo-Neia, Annamaria Massa, Carlo Bergamini, Alessandro Trentini, Giovanni De Rosa, Lorenzo Daniele, Fabiola Ciccosanti, Carlo Cervellati, Francesco Leone and Massimo Aglietta

Preoperative stereotactic radiosurgery for brain metastases: the STEP study protocol for a multicentre, prospective, phase-II trial

Surgery is an important therapeutic option for brain metastases. Currently, postoperative stereotactic radiosurgery (SRT) leads to 6-month and 1-year local control estimated at 70 and 62% respectively. However...

Authors: Angeline Ginzac, Guillaume Dupic, Lucie Brun, Ioana Molnar, Mélanie Casile, Xavier Durando, Pierre Verrelle, Jean-Jacques Lemaire, Toufic Khalil and Julian Biau

Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion

Cell-to-cell fusion is emerging as a key element of the metastatic process in various cancer types. We recently showed that hybrids made from the spontaneous merging of pre-malignant (IMR90 E6E7, i.e. E6E7) an...

Authors: Ariadna Brito, Candice Merle, Pauline Lagarde, Benjamin Faustin, Anne Devin, Lydia Lartigue and Frederic Chibon

Neoadjuvant everolimus plus letrozole versus fluorouracil, epirubicin and cyclophosphamide for ER-positive, HER2-negative breast cancer: a randomized pilot trial

Here we evaluated the feasibility, efficacy, tolerability, and treatment-mediated immune modulation of neoadjuvant everolimus plus letrozole versus chemotherapy in treating postmenopausal patients with ER-posi...

Authors: Wei Wu, Jiewen Chen, Heran Deng, Liang Jin, Zhanghai He, Nanyan Rao, Yan Nie, Yandan Yao, Yaping Yang, Fengxi Su and Jieqiong Liu

A panel of miRNAs as prognostic markers for African-American patients with triple negative breast cancer

To investigate the global expression profile of miRNAs, their impact on cellular signaling pathways, and their association with poor prognostic parameters in African-American (AA) patients with triple negative...

Authors: Safaa Turkistani, Bruna M. Sugita, Paolo Fadda, Rafael Marchi, Ali Afsari, Tammey Naab, Victor Apprey, Robert L. Copeland Jr, Michael C. Campbell, Luciane R. Cavalli and Yasmine Kanaan

Validity and reliability of the simplified Chinese patient-reported outcomes version of the common terminology criteria for adverse events

The psychometric properties of the simplified Chinese version of the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) have not been assessed. Therefore, we ai...

Authors: Shan-Shan Yang, Lei Chen, Ying Liu, Hai-Jun Lu, Bo-Jie Huang, Ai-Hua Lin, Ying Sun, Jun Ma, Fang-Yun Xie and Yan-Ping Mao

Feasibility and effectiveness of afatinib for poor performance status patients with EGFR-mutation-positive non-small-cell lung cancer: a retrospective cohort study

Afatinib is one of the standard treatments for patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC). However, data on the use of afatinib in patients with poor performa...

Authors: Chiao-En Wu, Ching-Fu Chang, Chen-Yang Huang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Ping-Chih Hsu and John Wen-Cheng Chang

Construction of a novel mRNA-signature prediction model for prognosis of bladder cancer based on a statistical analysis

Bladder cancer (BC) is a common malignancy neoplasm diagnosed in advanced stages in most cases. It is crucial to screen ideal biomarkers and construct a more accurate prognostic model than conventional clinica...

Authors: Jianpeng Li, Jinlong Cao, Pan Li, Zhiqiang Yao, Ran Deng, Lijun Ying and Junqiang Tian

Primary tumor surgery improves survival in non-metastatic primary urethral carcinoma patients: a large population-based investigation

Primary urethral carcinoma (PUC) is a rare genitourinary malignancy with a relatively poor prognosis. The aim of this study was to examine the impact of surgery on survival of patients diagnosed with PUC.

Authors: Jie Wu, Yu-Chen Wang, Wen-Jie Luo, Bo-Dai, Ding-Wei Ye and Yi-Ping Zhu

Transcriptional landscape of PTEN loss in primary prostate cancer

PTEN is the most frequently lost tumor suppressor in primary prostate cancer (PCa) and its loss is associated with aggressive disease. However, the transcriptional changes associated with PTEN loss in PCa have...

Authors: Eddie Luidy Imada, Diego Fernando Sanchez, Wikum Dinalankara, Thiago Vidotto, Ericka M. Ebot, Svitlana Tyekucheva, Gloria Regina Franco, Lorelei Ann Mucci, Massimo Loda, Edward Matthew Schaeffer, Tamara Lotan and Luigi Marchionni

Comparison of fatigue and fatigability correlates in Korean breast cancer survivors and differences in associations with anxiety, depression, sleep disturbance, and endocrine symptoms: a randomized controlled trial

Fatigue is one of the most common and burdensome symptoms experienced by cancer patients. In interventions intended to reduce fatigue in such patients, fatigability, or perception of fatigue contextualized to ...

Authors: Min Kyeong Jang, Jeehee Han, Sung Hae Kim, Yun Hee Ko, Soo Yeon Kim and Sue Kim

Real-world study of the impact of recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN) on quality of life and productivity in Europe

Although current therapy for patients with early-stage squamous cell carcinoma of the head and neck (SCCHN) is potentially curative, the recurrence rate is high. Patients with recurrent or metastatic (R/M) SCC...

Authors: Prianka Singh, Bryan Bennett, Tom Bailey, Gavin Taylor-Stokes, Ivana Rajkovic, Marta Contente, Sharon Curtis and Chris Curtis

Meta-analysis and indirect treatment comparison of modified FOLFIRINOX and gemcitabine plus nab-paclitaxel as first-line chemotherapy in advanced pancreatic cancer

Modified FOLFIRINOX and gemcitabine plus nab-paclitaxel (GEM-NAB) have been recommended as first-line therapies for advanced pancreatic cancer (PC). Due to the lack of evidence to directly compare them, we con...

Authors: Jiayuan Chen, Qingling Hua, Haihong Wang, Dejun Zhang, Lei Zhao, Dandan Yu, Guoliang Pi, Tao Zhang and Zhenyu Lin

Seven key hub genes identified by gene co-expression network in cutaneous squamous cell carcinoma

Cutaneous squamous cell carcinoma (cSCC) often follows actinic keratosis (AK) and is the second most common skin cancer worldwide. To reduce metastasis risk, it is important to diagnose and treat cSCC early. T...

Authors: Huizhen Chen, Jiankang Yang and Wenjuan Wu

A Phase 2a cohort expansion study to assess the safety, tolerability, and preliminary efficacy of CXD101 in patients with advanced solid-organ cancer expressing HR23B or lymphoma

This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients w...

Authors: Stephen W. Booth, Toby A. Eyre, John Whittaker, Leticia Campo, Lai Mun Wang, Elizabeth Soilleux, Daniel Royston, Gabrielle Rees, Murali Kesavan, Catherine Hildyard, Farasat Kazmi, Nick La Thangue, David Kerr, Mark R. Middleton and Graham P. Collins

Integration of RNA-Seq and proteomics data identifies glioblastoma multiforme surfaceome signature

Glioblastoma multiforme (GBM) is a highly lethal, stage IV brain tumour with a prevalence of approximately 2 per 10,000 people globally. The cell surface proteins or surfaceome serve as information gateway in ...

Authors: Saiful Effendi Syafruddin, Wan Fahmi Wan Mohamad Nazarie, Nurshahirah Ashikin Moidu, Bee Hong Soon and M. Aiman Mohtar

Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for lung adenocarcinoma

More and more studies have proven that circular RNAs (circRNAs) play vital roles in cancer development via sponging miRNAs. However, the expression pattern of competing endogenous RNA (ceRNA) in lung adenocarc...

Authors: Lei Gao and Ling Zhang

Systemic characterization of alternative splicing related to prognosis and immune infiltration in malignant mesothelioma

Malignant mesothelioma (MM) is a relatively rare and highly lethal tumor with few treatment options. Thus, it is important to identify prognostic markers that can help clinicians diagnose mesothelioma earlier ...

Authors: Jinzhi Lai, Hainan Yang and Tianwen Xu

Nomogram predict relapse-free survival of patients with thymic epithelial tumors after surgery

Hematological indicators and clinical characteristics play an important role in the evaluation of the progression and prognosis of thymic epithelial tumors. Therefore, we aimed to combine these potential indic...

Authors: Yang-Yu Huang, Lei-Lei Wu, Xuan Liu, Shen-Hua Liang and Guo-Wei Ma

Transcriptome sequencing and multi-plex imaging of prostate cancer microenvironment reveals a dominant role for monocytic cells in progression

Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tu...

Authors: Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P. Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G. Williams…

Association of emergence of new mutations in circulating tumuor DNA during chemotherapy with clinical outcome in metastatic colorectal cancer

The understanding of molecular changes in mCRC during treatment could be used to personalise therapeutic strategies. The aim of our study was to explore the association of circulating tumour DNA (ctDNA) with c...

Authors: Ning Jia, Lianpeng Chang, Xin Gao, Xiaohua Shi, Xuelin Dou, Mei Guan, Yajuan Shao, Ningning Li, Yuejuan Cheng, Hongyan Ying, Zhao Sun, Yanping Zhou, Lin Zhao, Jianfeng Zhou and Chunmei Bai

Long non-coding RNA PSMA3-AS1 promotes glioma progression through modulating the miR-411-3p/HOXA10 pathway

Glioma is a common type of brain tumor and is classified as low and high grades according to morphology and molecules. Growing evidence has proved that long non-coding RNAs (lncRNAs) play pivotal roles in nume...

Authors: Tianzao Huang, Yingxian Chen, Yile Zeng, Chaoyang Xu, Jinzhong Huang, Weipeng Hu, Xiangrong Chen and Huangde Fu

miR-29a-3p inhibits endometrial cancer cell proliferation, migration and invasion by targeting VEGFA/CD C42/PAK1

This study aimed to investigate the mechanism of miR-29a-3p in regulating endometrial cancer (EC) progression.

Authors: Aizhi Geng, Lin Luo, Fengyun Ren, Ling Zhang, Haiying Zhou and Xue Gao

Genetic polymorphisms and haplotypes of ERCC1 and ERCC2 associated with quality of life, depression, and anxiety status among patients with lung cancer

Patients with lung cancer (LC) have a poor quality of life (QoL) and easily suffer from psychological diseases. Previous studies focused less on the relationship between genetic factors and QoL, depression, an...

Authors: Yunxiang Tang, Ruike Zhang, Yinan Li, Shuyu Xu, Hao Wang, Jingzhou Xu, Lei Xiao, Yajing Wang, Jing Du, Yujia Huang and Tong Su