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  1. Content type: Case report

    Leptomeningeal metastasis (LM) is a predominantly late stage, devastating complication of a variety of malignant solid tumors. Diagnosis relies predominantly on neurological, radiographic, and cerebrospinal fl...

    Authors: Ann-Kathrin Stoppek, Sied Kebir, Andreas Junker, Kathy Keyvani, Stefan Zülow, Lazaros Lazaridis, Teresa Schmidt, Daniela Pierscianek, Martin Stuschke, Ulrich Sure, Christoph Kleinschnitz, Björn Scheffler, Lisa Zimmer and Martin Glas

    Citation: BMC Cancer 2019 19:995

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  2. Content type: Research article

    Long non coding RNAs (lncRNAs) are RNA molecules longer than 200 nucleotides that are not translated into proteins, but regulate the transcription of genes involved in different cellular processes, including c...

    Authors: Maria Barton, Julia Santucci-Pereira, Olivia G. Vaccaro, Theresa Nguyen, Yanrong Su and Jose Russo

    Citation: BMC Cancer 2019 19:994

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  3. Content type: Case report

    Limited evidence is available regarding the dissemination of tumor tissues due to compression during massage therapy, a routine procedure in patients with various symptoms in Asian countries.

    Authors: Shinji Miwa, Michi Kamei, Satoru Yoshida, Satoshi Yamada, Hisaki Aiba, Hiroyuki Tsuchiya and Takanobu Otsuka

    Citation: BMC Cancer 2019 19:993

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  4. Content type: Research article

    The glutathione S-transferases (GSTs) are a superfamily of phase II detoxifying enzymes that inactivates a wide variety of potential carcinogens through glutathione conjugation. Polymorphic changes in the GST gen...

    Authors: Nada Albarakati, Dareen Khayyat, Asharf Dallol, Jaudah Al-Maghrabi and Taoufik Nedjadi

    Citation: BMC Cancer 2019 19:991

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  5. Content type: Study protocol

    Biliary tract cancer (BTC) has a high mortality. Primary diagnosis is frequently delayed due to mostly unspecific symptoms, resulting in a high number of advanced cases at the time of diagnosis. Advanced BTCs ...

    Authors: L. Perkhofer, A. W. Berger, A. K. Beutel, E. Gallmeier, S. Angermeier, L. Fischer von Weikersthal, T. O. Goetze, R. Muche, T. Seufferlein and T. J. Ettrich

    Citation: BMC Cancer 2019 19:990

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  6. Content type: Research article

    Cervical cancer is a global public health problem and the second most common cancer causing morbidity and mortality in Ethiopia. Few available evidences revealed that despite distribution and severity of cervi...

    Authors: Kalkidan Solomon, Mulugeta Tamire and Mirgissa Kaba

    Citation: BMC Cancer 2019 19:989

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  7. Content type: Research article

    Laparoscopic surgery, fast-track perioperative treatment and XELOX chemotherapy are effective strategies for shortening the duration of hospital stay for cancer patients. This trial aimed to clarify the safety...

    Authors: Jun Li, Xiang-Xing Kong, Jiao-Jiao Zhou, Yong-Mao Song, Xue-Feng Huang, Gen-Hai Li, Xiao-Jiang Ying, Xiao-Yu Dai, Min Lu, Kai Jiang, Dong-Liang Fu, Xin-Lin Li, Jin-Jie He, Jian-Wei Wang, Li-Feng Sun, Dong Xu…

    Citation: BMC Cancer 2019 19:988

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  8. Content type: Research article

    The organisation and systematisation of health actions and services are essential to ensure patient safety and the effectiveness and efficiency of cancer care. The objective of this study was to analyse the st...

    Authors: Mario Jorge Sobreira da Silva, Gisele O’Dwyer and Claudia Garcia Serpa Osorio-de-Castro

    Citation: BMC Cancer 2019 19:987

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  9. Content type: Research article

    To examine differences in the plasma levels of miRNA-21, − 214, −34a, and -200a in patients with persistent high-risk human papillomavirus (hr-HPV) infection or with cervical lesions of different grades.

    Authors: Hongyun Wang, Dandan Zhang, Qing Chen and Ying Hong

    Citation: BMC Cancer 2019 19:986

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  10. Content type: Technical advance

    Breast cancer related lymphoedema (BCRL) is a common side effect of cancer treatment. Recently indocyanine green (ICG) fluorescent lymphography has become a popular method for imaging the lymphatics, however t...

    Authors: Hiroo Suami, Asha Heydon-White, Helen Mackie, Sharon Czerniec, Louise Koelmeyer and John Boyages

    Citation: BMC Cancer 2019 19:985

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  11. Content type: Research article

    Ovarian cancer (OC) is the seventh most common malignancy worldwide and the most lethal gynaecological malignancy. We aimed to explore global geographical patterns and temporal trends from 1973 to 2015 for 41 ...

    Authors: Yanting Zhang, Ganfeng Luo, Mengjie Li, Pi Guo, Yuejiao Xiao, Huanlin Ji and Yuantao Hao

    Citation: BMC Cancer 2019 19:984

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  12. Content type: Research article

    To determine the safety and efficacy of transarterial chemoembolization (TACE) combined with radiofrequency ablation (hereafter, TACE-RFA) in treating Barcelona Clinic Liver Cancer (BCLC) Stage A or B (hereaft...

    Authors: Yanqiao Ren, Yanyan Cao, Hong Ma, Xuefeng Kan, Chen Zhou, Jiacheng Liu, Qin Shi, Gansheng Feng, Bin Xiong and Chuansheng Zheng

    Citation: BMC Cancer 2019 19:983

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  13. Content type: Correction

    Following publication of the original article [1], the authors reported the name of R.J. Baatenburg de Jong was incorrectly tagged in the HTML version of the article.

    Authors: I. M. Verdonck-de Leeuw, F. Jansen, R. H. Brakenhoff, J. A. Langendijk, R. Takes, C. H. J. Terhaard, R. J. Baatenburg de Jong, J. H. Smit and C. R. Leemans

    Citation: BMC Cancer 2019 19:982

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    The original article was published in BMC Cancer 2019 19:765

  14. Content type: Research article

    To our knowledge, there are no studies to systematically compare the detailed clinical significance between curatively resected pancreatic head (ph) and body-tail (pbt) ductal adenocarcinoma based on the new 8...

    Authors: Weiwei Sheng, Ming Dong, Guosen Wang, Xiaoyang Shi, Wei Gao, Kewei Wang, He Song, Gang Shi and Xiaodong Tan

    Citation: BMC Cancer 2019 19:981

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  15. Content type: Research article

    While denosumab has been shown to prevent skeletal-related events in patients with bone metastasis, there is a concern that it may cause atypical femoral fracture (AFF). While AFF has been reported in patients...

    Authors: Momoko Takahashi, Yukinori Ozaki, Rika Kizawa, Jun Masuda, Kentaro Sakamaki, Keiichi Kinowaki, Taro Umezu, Chihiro Kondoh, Yuko Tanabe, Nobuko Tamura, Yuji Miura, Takashi Shigekawa, Hidetaka Kawabata, Noriyuki Baba, Haruo Iguchi and Toshimi Takano

    Citation: BMC Cancer 2019 19:980

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  16. Content type: Research article

    One critical step in the therapy of patients with localized pancreatic cancer is the determination of local resectability. The decision between primary surgery versus upfront local or systemic cancer therapy s...

    Authors: U. A. Wittel, D. Lubgan, M. Ghadimi, O. Belyaev, W. Uhl, W. O. Bechstein, R. Grützmann, W. M. Hohenberger, A. Schmid, L. Jacobasch, R. S. Croner, A. Reinacher-Schick, U. T. Hopt, A. Pirkl, H. Oettle, R. Fietkau…

    Citation: BMC Cancer 2019 19:979

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  17. Content type: Technical advance

    An External Quality Assessment (EQA) program was developed to investigate the status of estrogen receptor (ER), progesterone receptor (PR), and Ki-67 immunohistochemical (IHC) detection in breast cancer and to...

    Authors: Tianjie Pu, Ruohong Shui, Jie Shi, Zhiyong Liang, Wentao Yang, Hong Bu, Qin Li and Zhang Zhang

    Citation: BMC Cancer 2019 19:978

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  18. Content type: Research article

    Conventionally fractionated (CF) radiation therapy (RT) has been associated with lymphopenia, leading to compromised overall survival (OS) in cancer patients. It currently remains unknown if stereotactic body ...

    Authors: Guangyin Wu, Michael J. Baine, Nan Zhao, Sicong Li, Xiaobo Li and Chi Lin

    Citation: BMC Cancer 2019 19:977

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  19. Content type: Research article

    Nicotinic acetylcholine receptors (nAChRs) have been reported to be overexpressed in malignancies in humans and is associated with tumorigenesis and cell migration. In previous studies of gastric cancer, alpha...

    Authors: Xuefeng Bu, Anwei Zhang, Zhengwei Chen, Xuanfeng Zhang, Riting Zhang, Chaoyun Yin, Jie Zhang, Yao Zhang and Yulan Yan

    Citation: BMC Cancer 2019 19:976

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  20. Content type: Research article

    Multiple myeloma (MM) cells gain protection against drugs through interaction with bone marrow stromal cells (BMSCs). This form of resistance largely accounts for resistance to therapy in MM patients which war...

    Authors: Jahangir Abdi, Nasrin Rastgoo, Yan Chen, Guo An Chen and Hong Chang

    Citation: BMC Cancer 2019 19:975

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  21. Content type: Research article

    Recent studies have shown that immune-related adverse events (irAEs) caused by immune checkpoint inhibitors were associated with clinical benefit in patients with melanoma or lung cancer. In advanced gastric c...

    Authors: Ken Masuda, Hirokazu Shoji, Kengo Nagashima, Shun Yamamoto, Masashi Ishikawa, Hiroshi Imazeki, Masahiko Aoki, Takahiro Miyamoto, Hidekazu Hirano, Yoshitaka Honma, Satoru Iwasa, Natsuko Okita, Atsuo Takashima, Ken Kato and Narikazu Boku

    Citation: BMC Cancer 2019 19:974

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  22. Content type: Research article

    Although the dual anti-HER2 therapy, namely, pertuzumab plus trastuzumab and docetaxel, has shown promising results in HER2+ breast cancer patients, whether the dose, efficacy and safety of this treatment diff...

    Authors: Shanshan Chen, Yu Liang, Zhangying Feng and Mingxia Wang

    Citation: BMC Cancer 2019 19:973

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  23. Content type: Research article

    Castrate Resistant Prostate Cancer (CRPC) is an advanced disease resistant to systemic traditional medical or surgical castration, and resistance is primarily attributed to reactivation of AR through multiple ...

    Authors: Louie Semaan, Navneet Mander, Michael L. Cher and Sreenivasa R. Chinni

    Citation: BMC Cancer 2019 19:972

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  24. Content type: Research article

    Microsatellite instability (MSI), resulting from a defective mismatch repair system, occurs in approximately 15% of sporadic colorectal cancers (CRC). Since MSI is associated with a poor response to 5-fluorour...

    Authors: Amanda Frydendahl Boll Johansen, Christine Gaasdal Kassentoft, Michael Knudsen, Maria Bach Laursen, Anders Husted Madsen, Lene Hjerrild Iversen, Kåre Gotschalck Sunesen, Mads Heilskov Rasmussen and Claus Lindbjerg Andersen

    Citation: BMC Cancer 2019 19:971

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  25. Content type: Research article

    Neuroblastoma (NB) is a paediatric tumour of the sympathetic nervous system. Half of all cases are defined high-risk with an overall survival less than 40% at 5 years from diagnosis. The lack of in vitro model...

    Authors: P. Fusco, B. Parisatto, E. Rampazzo, L. Persano, C. Frasson, A. Di Meglio, A. Leslz, L. Santoro, B. Cafferata, A. Zin, E. Cimetta, G. Basso, M. R. Esposito and G. P. Tonini

    Citation: BMC Cancer 2019 19:970

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  26. Content type: Research article

    The aim of this study is to present and evaluate surgical resection and reconstructive techniques using autologous femoral head bone-grafting in treating partial acetabular defects arising from primary pelvic ...

    Authors: Wei Sun, Pengfei Zan, Xiaojun Ma, Yingqi Hua, Jiakang Shen and Zhengdong Cai

    Citation: BMC Cancer 2019 19:969

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  27. Content type: Research article

    Significant advances in the molecular profiling of gliomas, led the 2016 World Health Organization (WHO) Classification to include, for the first-time, molecular biomarkers in glioma diagnosis: IDH mutations and ...

    Authors: Cheila Brito, Ana Azevedo, Susana Esteves, Ana Rita Marques, Carmo Martins, Ilda Costa, Manuela Mafra, José M. Bravo Marques, Lúcia Roque and Marta Pojo

    Citation: BMC Cancer 2019 19:968

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  28. Content type: Case report

    Patients with metastatic renal carcinoma frequently have pre-existing renal impairment and not infrequently develop worsening renal function as a complication of their treatment. The presence of pancreatic met...

    Authors: Karin Purshouse, Sarah Chamberlain, Maria Soares, Mark Tuthill, Andrew Protheroe and David R. Mole

    Citation: BMC Cancer 2019 19:967

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  29. Content type: Case report

    Lymphoma and dysplasia are rare complications of long-standing Crohn’s disease. We report an exceptional case of a synchronous intestinal marginal zone B-cell lymphoma (MALT lymphoma) and colonic adenoma in a ...

    Authors: Amal Bennani, Ghizlane Kharrasse, Miry Achraf, Khanoussi Wafa, Ismaili Zahi, Kamaoui Imane and Bouziane Mohamed

    Citation: BMC Cancer 2019 19:966

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  30. Content type: Research article

    Sarcomatoid carcinoma of unknown primary (SCUP) is a rare entity of either poorly differentiated carcinoma with sarcoma-like differentiation or a true mixed lineage neoplasm. Limited data regarding clinicopath...

    Authors: Ryan W. Huey, Shalini Makawita, Lianchun Xiao, Aurelio Matamoros, Jeannelyn S. Estrella, Michael J. Overman, Gauri R. Varadhachary and Kanwal Raghav

    Citation: BMC Cancer 2019 19:965

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  31. Content type: Research article

    CpG Island Methylator Phenotype (CIMP) is an epigenetic phenotype in CRC characterized by hypermethylation of CpG islands in promoter regions of tumor suppressor genes, leading to their transcriptional silenci...

    Authors: Shailesh Mahesh Advani, Pragati Shailesh Advani, Derek W. Brown, Stacia M. DeSantis, Krittiya Korphaisarn, Helena M. VonVille, Jan Bressler, David S. Lopez, Jennifer S. Davis, Carrie R. Daniel, Amir Mehrvarz Sarshekeh, Dejana Braithwaite, Michael D. Swartz and Scott Kopetz

    Citation: BMC Cancer 2019 19:964

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  32. Content type: Research article

    Overexpression of fibroblast growth factor receptor 3 (FGFR3) has been linked to tumor progression in many types of cancer. The role of FGFR3 in melanoma remains unclear. In this study, we aimed to uncover the...

    Authors: Lei Li, Shuai Zhang, Hao Li and Haiyan Chou

    Citation: BMC Cancer 2019 19:963

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  33. Content type: Research article

    We previously reported the synergistic effect of S-1 and eribulin in preclinical models. In addition, our phase I study revealed the recommended dose for the phase II study of the combination therapy in advanc...

    Authors: Tsutomu Iwasa, Junji Tsurutani, Satomi Watanabe, Ryoji Kato, Yutaka Mizuno, Yasuyuki Kojima, Tsutomu Takashima, Nobuki Matsunami, Takashi Morimoto, Jun Yamamura, Shoichiro Ohtani, Yuko Tanabe, Tetsuhiro Yoshinami, Toshimi Takano, Yoshifumi Komoike and Kazuhiko Nakagawa

    Citation: BMC Cancer 2019 19:962

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  34. Content type: Research article

    Neuroblastoma is the most common extra-cranial solid tumor among children. Despite intensive treatment, patients with advanced disease mostly experience dismal outcomes. Here, we proposed the use of topotecan ...

    Authors: Piya Rujkijyanont, Apichat Photia, Chanchai Traivaree, Chalinee Monsereenusorn, Usanarat Anurathapan, Panya Seksarn, Darintr Sosothikul, Piti Techavichit, Kleebsabai Sanpakit, Kamon Phuakpet, Surapon Wiangnon, Thirachit Chotsampancharoen, Su-on Chainansamit, Somjai Kanjanapongkul, Arunotai Meekaewkunchorn and Suradej Hongeng

    Citation: BMC Cancer 2019 19:961

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  35. Content type: Case report

    Neuroendocrine tumors (NETs) are heterogeneous, widely distributed tumors arising from neuroendocrine cells. Gastrointestinal (GI)-NETs are the most common and NETs of the rectum represent 15, 2% of gastrointe...

    Authors: Gemma Bruera, Antonio Giuliani, Lucia Romano, Alessandro Chiominto, Alessandra Di Sibio, Stefania Mastropietro, Pierluigi Cosenza, Enrico Ricevuto, Mario Schietroma and Francesco Carlei

    Citation: BMC Cancer 2019 19:960

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  36. Content type: Research article

    HER3 mediates drug resistance against epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs), resulting in tumor relapse in lung cancers. Previously, we demonstrated that EGFR induces HER3 o...

    Authors: Yi-Fang Chang, Ken-Hong Lim, Ya-Wen Chiang, Zong-Lin Sie, Jungshan Chang, Ai-Sheng Ho and Chun-Chia Cheng

    Citation: BMC Cancer 2019 19:959

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  37. Content type: Research article

    We analyzed the changes in permeability of endothelial cell layers after photon irradiation, with a focus on the metalloproteases ADAM10 and ADAM17, and on VE-cadherin, components crucial for the integrity of ...

    Authors: Pascaline Nguemgo Kouam, Günther A. Rezniczek, Irenäus A. Adamietz and Helmut Bühler

    Citation: BMC Cancer 2019 19:958

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  38. Content type: Research article

    99mTc-Rituximab is a new specific radiopharmaceutical that binds to the CD20 receptor which is highly expressed on the surface of B cells. We conducted a study in which 99mTc-Rituximab was compared with filtered

    Authors: Jing-Jie Zhang, Wan-Chun Zhang, Cai-Xia An, Xiao-Min Li and Le Ma

    Citation: BMC Cancer 2019 19:956

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  39. Content type: Research article

    The efficacy of hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) remains unclear. We conducted a multi-center randomized phase II study comparing a sequential HAIC-sora...

    Authors: Masaaki Kondo, Manabu Morimoto, Satoshi Kobayashi, Shinichi Ohkawa, Hisashi Hidaka, Takahide Nakazawa, Hiroshi Aikata, Takeshi Hatanaka, Daichi Takizawa, Kotaro Matsunaga, Chiaki Okuse, Michihiro Suzuki, Masataka Taguri, Takako Ishibashi, Kazushi Numata, Shin Maeda…

    Citation: BMC Cancer 2019 19:954

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  40. Content type: Research article

    Gestational trophoblastic disease (GTD) is a heterogeneous group of diseases developed from trophoblasts. ASPP (Ankyrin-repeat, SH3-domain and proline-rich region containing protein) family proteins, ASPP1 and...

    Authors: Ka-Kui Chan, Esther Shuk-Ying Wong, Ivy Tsz-Lo Wong, Claire Ling-Yang Cheung, Oscar Gee-Wan Wong, Hextan Yuen-Sheung Ngan and Annie Nga-Yin Cheung

    Citation: BMC Cancer 2019 19:953

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  41. Content type: Research article

    Lymph-node (LN) metastasis is an important prognostic factor in resected pancreatic cancer. In this study, the prognostic value of American Joint Committee on Cancer (AJCC) 8th edition N stage, lymph-node rati...

    Authors: Min Su You, Sang Hyub Lee, Young Hoon Choi, Bang-sup Shin, Woo Hyun Paik, Ji Kon Ryu, Yong-Tae Kim, Dong Kee Jang, Jun Kyu Lee, Wooil Kwon, Jin-Young Jang and Sun-Whe Kim

    Citation: BMC Cancer 2019 19:952

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  42. Content type: Research article

    Strong associations exist between Balkan endemic nephropathy (BEN) and upper urothelial carcinomas (UUCs). However, the common etiology between the two remains unclear and there are no studies to date that vis...

    Authors: Danira Medunjanin, Zdenko Sonicki, John E. Vena, Ante Cvitkovic and Sara Wagner Robb

    Citation: BMC Cancer 2019 19:950

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  43. Content type: Research article

    In the quest for new anti-cancer drugs, the drug discovery process has shifted to screening of active ingredients in traditional eastern medicine. Matrine is an active alkaloid isolated from plants of the Soph...

    Authors: Yuming Zou, Melika Sarem, Shengnan Xiang, Honggang Hu, Weidong Xu and V. Prasad Shastri

    Citation: BMC Cancer 2019 19:949

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  44. Content type: Research article

    Transcription-coupled nucleotide excision repair (TC-NER) plays a prominent role in the removal of DNA adducts induced by platinum-based chemotherapy reagents. Cockayne syndrome protein B (CSB), the master sen...

    Authors: Zhenbang Yang, Chunling Liu, Hongjiao Wu, Yuning Xie, Hui Gao and Xuemei Zhang

    Citation: BMC Cancer 2019 19:948

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  45. Content type: Research article

    Quality of life among prostate cancer survivors varies by socio-demographic factors and treatment type received; however, less in known about differences in functional outcomes by method of presentation. We in...

    Authors: David W. Donnelly, Linda C. Vis, Therese Kearney, Linda Sharp, Damien Bennett, Sarah Wilding, Amy Downing, Penny Wright, Eila Watson, Richard Wagland, William R. Cross, Malcolm D. Mason, Sabine Siesling, Jeannette G. van Manen, Adam W. Glaser and Anna Gavin

    Citation: BMC Cancer 2019 19:947

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  46. Content type: Research article

    Biliary rhabdomyosarcoma (RMS) is the most common biliary tumor in children. The management of affected patients contains unique challenges because of the rarity of this tumor entity and its critical location ...

    Authors: Cristian Urla, Steven W. Warmann, Monika Sparber-Sauer, Andreas Schuck, Ivo Leuschner, Thomas Klingebiel, Gunnar Blumenstock, Guido Seitz, Ewa Koscielniak and Jörg Fuchs

    Citation: BMC Cancer 2019 19:945

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