Articles

Chemotherapy-induced neutropenia and treatment efficacy in advanced non-small-cell lung cancer: a pooled analysis of 6 randomized trials

Chemotherapy-induced neutropenia (CIN) has been demonstrated to be a prognostic factor in several cancer conditions. We previously found a significant prognostic value of CIN on overall survival (OS), in a poo...

Authors: Piera Gargiulo, Laura Arenare, Cesare Gridelli, Alessandro Morabito, Fortunato Ciardiello, Vittorio Gebbia, Paolo Maione, Alessia Spagnuolo, Giuliano Palumbo, Giovanna Esposito, Carminia Maria Della Corte, Floriana Morgillo, Gianfranco Mancuso, Raimondo Di Liello, Adriano Gravina, Clorinda Schettino…

Compression therapy using surgical gloves does not prevent paclitaxel-induced peripheral neuropathy: results from a double-blind phase 2 trial

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of paclitaxel (PTX). There is no known prophylactic measure, although there are some reports of prevention with compression therapy ...

Authors: Haruru Kotani, Mitsuo Terada, Makiko Mori, Nanae Horisawa, Kayoko Sugino, Ayumi Kataoka, Yayoi Adachi, Naomi Gondou, Akiyo Yoshimura, Masaya Hattori, Masataka Sawaki, Chihoko Takahata, Makiko Kobara and Hiroji Iwata

Novel meso-substituted porphyrin derivatives and its potential use in photodynamic therapy of cancer

Photodynamic therapy (PDT) is an anticancer treatment that utilizes the interaction of light and a photosensitiser (PS), promoting tumour cell death mediated by generation of reactive oxygen species. In this s...

Authors: Pablo Vallecorsa, Gabriela Di Venosa, M. Belén Ballatore, Dario Ferreyra, Leandro Mamone, Daniel Sáenz, Gustavo Calvo, Edgardo Durantini and Adriana Casas

Elevated mature monocytes in bone marrow accompanied with a higher IPSS-R score predicts a poor prognosis in myelodysplastic syndromes

Myelodysplastic syndromes (MDS) is a group of heterogeneous myeloid clonal diseases originating from hematopoietic stem cells. Clinically, elevated mature monocyte in bone marrow is often observed, but its cli...

Authors: An Wu, Panpan Gao, Ningning Wu, Cong Shi, Zhenya Huang, Chunmeng Rong, Ye Sun, Lixia Sheng, Guifang Ouyang and Qitian Mu

Combination of gemcitabine, nab-paclitaxel, and S-1(GAS) as the first-line treatment for patients with locally advanced or advanced pancreatic ductal adenocarcinoma: study protocol for an open-label, single-arm phase I study

Pancreatic ductal adenocarcinoma (PDAC) is still a highly fatal malignancy among the most common cancers. More powerful treatments are expecting to bring hope for patients. Biweekly gemcitabine/nab-paclitaxel/...

Authors: Chen Chang, Xiaofen Li and Dan Cao

Using patients’ own knowledge of early sensations and symptoms to develop an interactive, individualized e-questionnaire to facilitate early diagnosis of lung cancer

One reason for the often late diagnosis of lung cancer (LC) may be that potentially-indicative sensations and symptoms are often diffuse, and may not be considered serious or urgent, making their interpretatio...

Authors: Adrian Levitsky, Britt-Marie Bernhardson, Ingela Henoch, Maria Olin, Karl Kölbeck, Nadja Rystedt, Carol Tishelman and Lars E. Eriksson

Risk and outcome of subsequent malignancies after radioactive iodine treatment in differentiated thyroid cancer patients

We identified differentiated thyroid cancer (DTC) survivors from SEER registries and performed Poisson regression to calculate the relative risks (RRs) of subsequent malignancies (SMs) by different sites assoc...

Authors: Xiaoran Mei, Xiaoqin Yao, Fang Feng, Weiwei Cheng and Hui Wang

Plasma fibrinogen acts as a predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer: a retrospective study of 1004 Chinese breast cancer patients

The aim of this study was to evaluate the relationship between pre-treatment plasma fibrinogen (Fib) level and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients a...

Authors: Yihua Wang, Yu Wang, Rui Chen, Zhenrong Tang, Yang Peng, Yudi Jin, Ailin Lan, Nan Ding, Yuran Dai, Linshan Jiang and Shengchun Liu

Cancer-associated mutations reveal a novel role for EpCAM as an inhibitor of cathepsin-L and tumor cell invasion

EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling pathways and epithelial-to-mesenchymal transition. ...

Authors: Narendra V. Sankpal, Taylor C. Brown, Timothy P. Fleming, John M. Herndon, Anusha A. Amaravati, Allison N. Loynd and William E. Gillanders

Descriptive epidemiology of nasopharyngeal carcinoma at Tikur Anbessa Hospital, Ethiopia

Nasopharyngeal cancer is distinguished from other cancers of the head and neck in its epidemiology, histopathology, clinical characteristics, and therapeutic outcome. Its unique clinico-epidemiologic pattern o...

Authors: Elizabeth Tadesse Beyene, Siraw Girum Ketema, Assaye Nibret Alebachew, Mizan Yeshanew Saleh and Tsigereda Atumo Gebremariam

The association between cognitive impairment and breast and colorectal cancer screening utilization

Undergoing cancer screening is a debatable topic in patients with cognitive impairment. In this study, we aimed to examine the utilization and predictors of breast and colorectal cancer screening among screeni...

Authors: Shuang Yang, Jiang Bian, Thomas J. George, Karen Daily, Dongyu Zhang, Dejana Braithwaite and Yi Guo

Magnetic resonance imaging-guided stereotactic body radiotherapy for prostate cancer (mirage): a phase iii randomized trial

Stereotactic body radiotherapy (SBRT) is becoming increasingly used in treating localized prostate cancer (PCa), with evidence showing similar toxicity and efficacy profiles when compared with longer courses o...

Authors: Ting Martin Ma, James M. Lamb, Maria Casado, Xiaoyan Wang, T. Vincent Basehart, Yingli Yang, Daniel Low, Ke Sheng, Nzhde Agazaryan, Nicholas G. Nickols, Minsong Cao, Michael L. Steinberg and Amar U. Kishan

Comparison between FOLFIRINOX and gemcitabine plus nab-paclitaxel including sequential treatment for metastatic pancreatic cancer: a propensity score matching approach

FOLFIRINOX (FFX) and Gemcitabine plus nab-paclitaxel (GnP) have been recommended as the first-line chemotherapy for metastatic pancreatic cancer (mPC). However, the evidence is lacking comparing not only two r...

Authors: Jung Won Chun, Sang Hyub Lee, Joo Seong Kim, Namyoung Park, Gunn Huh, In Rae Cho, Woo Hyun Paik, Ji Kon Ryu and Yong-Tae Kim

The clinical features and prognosis of patients with mucinous breast carcinoma compared with those with infiltrating ductal carcinoma: a population-based study

At present, the characteristics of mucinous breast carcinoma (MBC) and the factors affecting its prognosis are controversial. We compared the clinical features of MBC with those of infiltrating ductal carcinom...

Authors: Xingtong Zhou, Zhibo Zheng, Yan Li, Weiwei Zhao, Yan Lin, Jieshi Zhang and Qiang Sun

Sex disparities in vitamin D status and the impact on systemic inflammation and survival in rectal cancer

We reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating lev...

Authors: Hanna Abrahamsson, Sebastian Meltzer, Vidar Nyløkken Hagen, Christin Johansen, Paula A. Bousquet, Kathrine Røe Redalen and Anne Hansen Ree

Subdivision of de-novo metastatic nasopharyngeal carcinoma based on tumor burden and pretreatment EBV DNA for therapeutic guidance of locoregional radiotherapy

Nasopharyngeal carcinoma (NPC) is a malignancy predominantly associated with infection by the Epstein-Barr virus (EBV). Approximately 12,900 new cases of NPC occur each year, with more than 70% of cases occurr...

Authors: Jin-Hao Yang, Xue-Song Sun, Bei-Bei Xiao, Li-Ting Liu, Shan-Shan Guo, Jia-Dong Liang, Guo-Dong Jia, Lin-Quan Tang, Qiu-Yan Chen and Hai-Qiang Mai

Optimal margins for early stage peripheral lung adenocarcinoma resection

A pathologically confirmed negative margin is required when performing sublobar resection in patients with early stage peripheral lung adenocarcinoma. However, the optimal margin distance to ensure complete tu...

Authors: Pan Yin, Bingqing Yue, Ji Zhang, Dong Liu, Dongyu Bai, Guang Zhao, Chutong Huang, Guojun Geng, Jie Jiang, Yongxiang Su, Xiuyi Yu and Jingyu Chen

Development and validation of a survival nomogram for patients with Siewert type II/III adenocarcinoma of the esophagogastric junction based on real-world data

The clinical staging systems for adenocarcinoma of the esophagogastric junction (AEG) are controversial. We aimed to propose a prognostic nomogram based on real-world data for predicting survival of Siewert ty...

Authors: Jian Chen, Yu-Jian Xia, Tian-Yu Liu, Yuan-Hui Lai, Ji-Shang Yu, Tian-Hao Zhang, Shiyin Ooi and Yu-Long He

Potential prognostic factors in progression-free survival for patients with cervical cancer

Cervical cancer continues to be one of the leading causes of cancer deaths among females in low and middle-income countries. In this study, we aimed to assess the independent prognostic value of clinical and p...

Authors: Hui-Hui Chen, Wei-Yu Meng, Run-Ze Li, Qing-Yi Wang, Yu-Wei Wang, Hu-Dan Pan, Pei-Yu Yan, Qi-Biao Wu, Liang Liu, Xiao-Jun Yao, Min Kang and Elaine Lai-Han Leung

Orthotopic model of lung cancer: isolation of bone micro-metastases after tumor escape from Osimertinib treatment

Osimertinib is a third generation tyrosine kinase inhibitor (TKI) that targets the epidermal growth factor receptor (EGFR) in lung cancer. However, although this molecule is not subject to some of the resistan...

Authors: Ulrich Jarry, Mégane Bostoën, Raphaël Pineau, Laura Chaillot, Valentine Mennessier, Pierre Montagne, Emilie Motte, Marjorie Gournay, Arnaud Le Goff, Thierry Guillaudeux and Rémy Pedeux

Impact of relative dose intensity of oxaliplatin in adjuvant therapy among stage III colon cancer patients on early recurrence: a retrospective cohort study

Oxaliplatin-based therapy with FOLFOX-4 or CAPOX administered over 6 months remains the standard adjuvant treatment for stage III colon cancer (CC) patients. However, many patients experience dose reduction or...

Authors: Jolanta Żok, Michał Bieńkowski, Barbara Radecka, Jan Korniluk, Krzysztof Adamowicz and Renata Duchnowska

Correction to: Mitochondrial DNA abnormalities provide mechanistic insight and predict reactive oxygen species-stimulating drug efficacy

Authors: Tarek Zaidieh, James R. Smith, Karen E. Ball and Qian An

Invasive breast Cancer treatment in Tanzania: landscape assessment to prepare for implementation of standardized treatment guidelines

Incidence of breast cancer continues to rise in low- and middle-income countries, with data from the East African country of Tanzania predicting an 82% increase in breast cancer from 2017 to 2030. We aimed to ...

Authors: Rupali Sood, Nestory Masalu, Roisin M. Connolly, Christina A. Chao, Lucas Faustine, Cosmas Mbulwa, Benjamin O. Anderson and Anne F. Rositch

No evidence to support the impact of migration background on treatment response rates and cancer survival: a retrospective matched-pair analysis in Germany

Immigration has taken the central stage in world politics, especially in the developed countries like Germany, where the continuous flow of immigrants has been well documented since 1960s. Strikingly, emerging...

Authors: Roman Rüdiger, Franziska Geiser, Manuel Ritter, Peter Brossart, Mignon-Denise Keyver-Paik, Andree Faridi, Hartmut Vatter, Friedrich Bootz, Jennifer Landsberg, Jörg C. Kalff, Ulrich Herrlinger, Glen Kristiansen, Torsten Pietsch, Stefan Aretz, Daniel Thomas, Lukas Radbruch…

Comparison of dose-dense vs. 3-weekly paclitaxel and carboplatin in the first-line treatment of ovarian cancer in a propensity score-matched cohort

Benefit of carboplatin and dose-dense weekly paclitaxel (ddCT) in first line treatment of ovarian cancer patients has been different in Western and Asian studies. In the present study we compare progression-fr...

Authors: Rafaela Pirolli, Viviane Teixeira Loiola de Alencar, Felipe Leonardo Estati, Adriana Regina Gonçalves Ribeiro, Daniella Yumi Tsuji Honda, Mariana de Oliveira, Joao Paulo da Silveira Nogueira Lima, Elizabeth Santana dos Santos, Andrea Paiva Gadelha Guimarães, Glauco Baiocchi and Alexandre André Balieiro Anastácio da Costa

A nomogram predicting overall survival in patients with non-metastatic pancreatic head adenocarcinoma after surgery: a population-based study

Pancreatic head adenocarcinoma (PHAC), a malignant tumour, has a very poor prognosis, and the existing prognostic tools lack good predictive power. This study aimed to develop a better nomogram to predict over...

Authors: Wenbo Zou, Zizheng Wang, Fei Wang, Gong Zhang and Rong Liu

Poor prognosis of male triple-positive breast Cancer patients: a propensity score matched SEER analysis and molecular portraits

The purpose of this study was to explore clinicalpathology features, molecular features and outcome of male breast cancer patients who expressed ER, PR as well as HER-2, namely triple-positive male breast canc...

Authors: Biyuan Wang, Hui Wang, Andi Zhao, Mi Zhang and Jin Yang

Reconstructive outcome analysis of the impact of neoadjuvant chemotherapy on immediate breast reconstruction: a retrospective cross-sectional study

Neoadjuvant chemotherapy (NACT) was initially applied to locally advanced breast cancer to convert advanced lesions to an operable status. Currently, its application has been expanded to enhance overall oncolo...

Authors: Jia-Ruei Yang, Wen-Ling Kuo, Chi-Chang Yu, Shin-Cheh Chen and Jung-Ju Huang

Recipient C7 rs9292795 genotype and the risk of hepatocellular carcinoma recurrence after orthotopic liver transplantation in a Han Chinese population

Complement component(C7) gene has been shown to influence the prognosis in Hepatocellular carcinoma (HCC) patients. The association between C7 and HCC recurrence after orthotopic liver transplantation (OLT), h...

Authors: Zhongyi Jiang, Qianwei Jiang, Xu Fang, Pusen Wang, Weitao Que, Hao Li, Yang Yu, Xueni Liu, Chunguang Wang and Lin Zhong

Efficacy of positron emission tomography in diagnosis of lateral lymph node metastases in patients with rectal Cancer: a retrospective study

The presence of lateral pelvic lymph node (LLN) metastasis is an essential prognostic factor in rectal cancer patients. Thus, preoperative diagnosis of LLN metastasis is clinically important to determine the t...

Authors: Ryohei Yukimoto, Mamoru Uemura, Takahiro Tsuboyama, Tsuyoshi Hata, Shiki Fujino, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Taishi Hata, Hirofumi Yamamoto, Tsunekazu Mizushima, Akira Kida, Mamoru Furuyashiki, Yuichiro Doki and Hidetoshi Eguchi

Prognostic value of serum uric acid and tumor response to induction chemotherapy in locally advanced nasopharyngeal carcinoma

To explore the combined predictive value of serum uric acid (SUA) and tumor response to induction chemotherapy (IC) in locally advanced nasopharyngeal carcinoma (LANPC) patients receiving IC followed by concur...

Authors: Yuanji Xu, Zijie Wu, Wangzhong Ye, Youping Xiao, Wei Zheng, Qinyan Chen, Penggang Bai, Zhizhong Lin and Chuanben Chen

Clinical and prognostic features of patients with detailed RAS/BRAF-mutant colorectal cancer in Japan

RAS/BRAF^V600E mutations are the most remarkable oncogenic driver mutations in colorectal cancer (CRC) and play an important role in treatment selection. No data are available regarding the clinical and prognostic...

Authors: Tatsuki Ikoma, Mototsugu Shimokawa, Masahito Kotaka, Toshihiko Matsumoto, Hiroki Nagai, Shogen Boku, Nobuhiro Shibata, Hisateru Yasui and Hironaga Satake

Dynamic change of serum CA19–9 levels in benign and malignant patients with obstructive jaundice after biliary drainage and new correction formulas

CA19–9 is one of the most widely used tumor markers in biliary-pancreatic diseases. The measured value may not factually reflect the genuine CA19–9 level secreted by tumor, which affected by biliary obstructio...

Authors: Bangbo Zhao, Qin Cheng, Hongtao Cao, Xingtong Zhou, Tianhao Li, Liangbo Dong and Weibin Wang

The evolution of the socio-cultural and religious characteristics of cancer patients in Morocco: case of the National Institute of Oncology Rabat

In 2020, Morocco recorded more than 59,370 new cases of cancer and more than 35,265 cases of death (International Agency for Research on Cancer, Annual report Morocco, 2020). Cancer is always accompanied by so...

Authors: Fahd Elkhalloufi, Saber Boutayeb, Fouzia Mamouch, Latifa Rakibi, Sanae Elazzouzi and Hassan Errihani

Retrospective analysis of real-world treatment patterns and clinical outcomes in patients with advanced non-small cell lung cancer starting first-line systemic therapy in the United Kingdom

The treatment landscape for advanced non-small cell lung cancer (aNSCLC) has evolved rapidly since immuno-oncology (IO) therapies were introduced. This study used recent data to assess real-world treatment pat...

Authors: Jason Lester, Carles Escriu, Sarah Khan, Emma Hudson, Talal Mansy, Andrew Conn, Samuel Chan, Ceri Powell, Juliet Brock, John Conibear, Lauren Nelless, Vaneet Nayar, Xiaohui Zhuo, Adeline Durand, Amerah Amin, Peter Martin…

Checkpoint inhibition in combination with an immunoboost of external beam radiotherapy in solid tumors (CHEERS): study protocol for a phase 2, open-label, randomized controlled trial

While the introduction of checkpoint inhibitors (CPIs) as standard of care treatment for various tumor types has led to considerable improvements in clinical outcome, the majority of patients still fail to res...

Authors: Mathieu Spaas, Nora Sundahl, Eva Hulstaert, Vibeke Kruse, Sylvie Rottey, Daan De Maeseneer, Veerle Surmont, Annabel Meireson, Lieve Brochez, Dries Reynders, Els Goetghebeur, Robbe Van den Begin, Dirk Van Gestel, Vincent Renard, Piet Dirix, Pieter Mestdagh…

Mechanism and risk factors of nausea and vomiting after TACE: a retrospective analysis

The mechanism of postoperative nausea and vomiting after TACE is not clear. This study retrospectively analyzed the patient data to explore the mechanism and risk factors of postoperative nausea and vomiting a...

Authors: Haohao Lu, Chuansheng Zheng, Bin Liang and Bin Xiong

Phase 3 multicenter randomized trial of PSMA PET/CT prior to definitive radiation therapy for unfavorable intermediate-risk or high-risk prostate cancer [PSMA dRT]: study protocol

Definitive radiation therapy (dRT) is an effective initial treatment of intermediate-risk (IR) and high-risk (HR) prostate cancer (PCa). PSMA PET/CT is superior to standard of care imaging (CT, MRI, bone scan)...

Authors: Jeremie Calais, Shaojun Zhu, Nader Hirmas, Matthias Eiber, Boris Hadaschik, Martin Stuschke, Ken Herrmann, Johannes Czernin, Amar U. Kishan, Nicholas G. Nickols, David Elashoff and Wolfgang P. Fendler

Thoracic radiotherapy and concurrent almonertinib for unresectable stage III EGFR-mutated non-small-cell lung cancer: a phase 2 study

Concurrent chemo-radiotherapy remains the standard treatment in unresectable stage III non-small-cell lung cancer (NSCLC) patients. Several studies have shown a potential value of concurrent epidermal growth f...

Authors: Lucheng ZHU, Changlin Zou, Zhanchun Zhang, Jianfang Wang, Li Yang, Chuangzhou Rao, Zhiping Yang, Jiafeng Liang, Bing Xia and M. A. Shenglin

A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker

Disulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of copper when administered with disulfiram in patien...

Authors: Kristen C. Kelley, Kenneth F. Grossman, Mary Brittain-Blankenship, Kelli M. Thorne, Wallace L. Akerley, Moises C. Terrazas, Ken M. Kosak, Kenneth M. Boucher, Saundra S. Buys, Kimberly A. McGregor, Theresa L. Werner, Neeraj Agarwal, John R. Weis, Sunil Sharma, John H. Ward, Thomas P. Kennedy…

The effects of secondary iron overload and iron chelation on a radiation-induced acute myeloid leukemia mouse model

Patients with myelodysplastic syndrome (MDS) require chronic red blood cell (RBC) transfusion due to anemia. Multiple RBC transfusions cause secondary iron overload and subsequent excessive generation of react...

Authors: Lap Shu Alan Chan, Lilly ChunHong Gu and Richard A. Wells

Geospatial analysis, web-based mapping and determinants of prostate cancer incidence in Georgia counties: evidence from the 2012–2016 SEER data

Prostate cancer (CaP) cases are high in the United States. According to the American Cancer Society, there are an estimated number of 174,650 CaP new cases in 2019. The estimated number of deaths from CaP in 2...

Authors: Justice Moses K. Aheto, Ovie A. Utuama and Getachew A. Dagne

Overexpression of TNFα induces senescence, autophagy and mitochondrial dysfunctions in melanoma cells

Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine with both anti-tumorigenic and pro-tumorigenic activity, affecting tumor cell biology, the balance between cell survival and death. The final effect...

Authors: Silvia Tyciakova, Valeria Valova, Barbora Svitkova and Miroslava Matuskova

Randomized phase II study of daily and alternate-day administration of S-1 for adjuvant chemotherapy in completely-resected stage I non-small cell lung cancer: results of the Setouchi Lung Cancer Group Study 1301

The aim of this multicenter, randomized phase II study was to analyze the feasibility and safety of alternate-day S-1, an oral fluoropyrimidine, for adjuvant chemotherapy in patients with completely resected p...

Authors: Norihito Okumura, Junichi Soh, Hiroyuki Suzuki, Masao Nakata, Toshiya Fujiwara, Hiroshige Nakamura, Makoto Sonobe, Takuji Fujinaga, Kazuhiko Kataoka, Kenichi Gemba, Masafumi Kataoka, Katsuyuki Hotta, Hiroshige Yoshioka, Keitaro Matsuo, Junichi Sakamoto, Hiroshi Date…

Artificial pneumothorax improves radiofrequency ablation of pulmonary metastases of hepatocellular carcinoma close to mediastinum

To investigate the feasibility, safety and efficacy of percutaneous radiofrequency ablation (RFA) of pulmonary metastases from hepatocellular carcinoma (HCC) contiguous with the mediastinum using the artificia...

Authors: Taiyang Zuo, Wenli Lin, Fengyong Liu and Jinshun Xu

Discrepancy in p16 expression in patients with HPV-associated head and neck squamous cell carcinoma in Thailand: clinical characteristics and survival outcomes

Lower prevalence HPV infection has been previously reported in Thai population when compared with Western countries. p16 expression indicates HPV-associated oropharyngeal squamous cell carcinoma (OPSCC), but n...

Authors: Lalida Arsa, Teerada Siripoon, Narumol Trachu, Sasithorn Foyhirun, Duangjai Pangpunyakulchai, Suda Sanpapant, Natini Jinawath, Poompis Pattaranutaporn, Artit Jinawath and Nuttapong Ngamphaiboon

Primary tumor resection improves prognosis of unresectable carcinomas of the transverse colon including flexures with liver metastasis: a preliminary population-based analysis

Studies on unresectable colorectal cancer liver metastasis(CRLM) rarely analyze the prognosis of the patients from the point of colonic subsites. We aimed to evaluate the effect of primary tumor resection (PTR...

Authors: Jiefeng Zhao, Jinfeng Zhu, Rui Sun, Chao Huang, Rongfa Yuan and Zhengming Zhu

Associations of specific-age and decade recall body mass index trajectories with obesity-related cancer

Excess body fatness, commonly approximated by a one-off determination of body mass index (BMI), is associated with increased risk of at least 13 cancers. Modelling of longitudinal BMI data may be more informat...

Authors: Charlotte Watson, Andrew G. Renehan and Nophar Geifman

Clinical significance and risk factors of International Society of Urological Pathology (ISUP) grade upgrading in prostate cancer patients undergoing robot-assisted radical prostatectomy

The objective of this study is to investigate the clinical significance and risk factors of upgrading in the International Society of Urological Pathology (ISUP) Grade Group System in men undergoing robot-assi...

Authors: Yuta Takeshima, Yuta Yamada, Taro Teshima, Tetsuya Fujimura, Shigenori Kakutani, Yuji Hakozaki, Naoki Kimura, Yoshiyuki Akiyama, Yusuke Sato, Taketo Kawai, Daisuke Yamada and Haruki Kume

The value of complete remission according to positron emission tomography prior to autologous stem cell transplantation in lymphoma: a population-based study showing improved outcome

Chimeric antigen-receptor T-cell and bispecific antibody therapies will likely necessitate a reconsideration of the role of autologous stem-cell transplantation (ASCT) in lymphoma. Patients who are likely to p...

Authors: Kristina Noring, Mattias Carlsten, Kristina Sonnevi and Björn Engelbrekt Wahlin