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  1. To investigate the clinical impact of sarcopenia and skeletal muscle density (SMD) among patients with metastatic pancreatic adenocarcinoma who underwent palliative first line gemcitabine-based chemotherapy.

    Authors: In-Ho Kim, Moon Hyung Choi, In Seok Lee, Tae Ho Hong and Myung Ah. Lee

    Citation: BMC Cancer 2021 21:77

    Content type: Research article

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  2. Breast cancer is the most frequently diagnosed malignancy among women. However, the role of microRNA (miRNA) expression in breast cancer progression is not fully understood. In this study we examined predictiv...

    Authors: Adriane F. Evangelista, Renato J. Oliveira, Viviane A. O. Silva, Rene A. D. C. Vieira, Rui M. Reis and Marcia M. C. Marques

    Citation: BMC Cancer 2021 21:76

    Content type: Research article

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  3. A serious syndrome for cancer in-patients, delirium risk increases with age and medical acuity. Screening tools exist but detection is frequently delayed or missed. We test the ‘Single Question in Delirium’ (S...

    Authors: Megan B. Sands, Swapnil Sharma, Lindsay Carpenter, Andrew Hartshorn, Jessica T. Lee, Sanja Lujic, Megan E. Congdon, Angus M. Buchanan, Meera Agar and Janette L. Vardy

    Citation: BMC Cancer 2021 21:75

    Content type: Research article

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  4. Patients with lung cancer who are treated with carboplatin-based chemotherapy regimens often experience chemotherapy-induced nausea and vomiting (CINV). However, knowledge on the effect of regimen and cofactor...

    Authors: Toshinobu Hayashi, Mototsugu Shimokawa, Koichi Matsuo, Hirotoshi Iihara, Kei Kawada, Takafumi Nakano and Takashi Egawa

    Citation: BMC Cancer 2021 21:74

    Content type: Research article

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  5. We have performed a head to head comparison of all-oral triplet combination of ixazomib, lenalidomide and dexamethasone (IRD) versus lenalidomide and dexamethasone (RD) in patients with relapsed and refractory...

    Authors: Jiri Minarik, Tomas Pika, Jakub Radocha, Alexandra Jungova, Jan Straub, Tomas Jelinek, Ludek Pour, Petr Pavlicek, Martin Mistrik, Lucie Brozova, Petra Krhovska, Katerina Machalkova, Pavel Jindra, Ivan Spicka, Hana Plonkova, Martin Stork…

    Citation: BMC Cancer 2021 21:73

    Content type: Research article

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  6. p-Boronophenylalanine (10BPA) is a powerful 10B drug used in current clinical trials of BNCT. For BNCT to be successful, a high (500 mg/kg) dose of 10BPA must be administered over a few hours. Here, we report BNC...

    Authors: Tohru Yoneyama, Shingo Hatakeyama, Mihoko Sutoh-Yoneyama, Taku Yoshiya, Tsuyoshi Uemura, Takehiro Ishizu, Minoru Suzuki, Shingo Hachinohe, Shintaro Ishiyama, Motohiro Nonaka, Michiko N. Fukuda and Chikara Ohyama

    Citation: BMC Cancer 2021 21:72

    Content type: Research article

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  7. Breast cancer is the second most common causes of women’s death, worldwide. Data on risk factors associated with female breast cancer in the Afghan population is very limited. The aim of our study was to ident...

    Authors: Zekrullah Baset, Jamshid Abdul-Ghafar, Yasmin Nadeem Parpio and Ahmed Maseh Haidary

    Citation: BMC Cancer 2021 21:71

    Content type: Research article

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  8. Use of statins is associated with a reduced risk of hepatocellular carcinoma (HCC). However, the effect of statin use on HCC recurrence is unclear. This study aimed to evaluate the effect of statin use on recu...

    Authors: Shih-Yu Yang, Chih-Chi Wang, Kuang-Den Chen, Yueh-Wei Liu, Chih-Che Lin, Ching-Hui Chuang, Yu-Chieh Tsai, Chih-Chien Yao, Yi-Hao Yen, Chang-Chun Hsiao, Tsung-Hui Hu and Ming-Chao Tsai

    Citation: BMC Cancer 2021 21:70

    Content type: Research article

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  10. This study was aimed to explore the predictive ability of tumor infiltrating neutrophil (TIN) in patients with breast cancer treated with neoadjuvant chemotherapy (NACT). Furthermore, the significance of TIN’s...

    Authors: Sheng-Kai Geng, Shao-Mei Fu, Shi-Hong Ma, Yi-Peng Fu and Hong-Wei Zhang

    Citation: BMC Cancer 2021 21:68

    Content type: Research article

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  11. The role of nicotinamide N-methyltransferase (NNMT) in ovarian cancer is still elusive. Our aim is to explore the expression of NNMT in ovarian cancer and to assess its association with patient prognosis and t...

    Authors: Jun Li, Huiran Yue, Hailin Yu, Xin Lu and Xiaohong Xue

    Citation: BMC Cancer 2021 21:67

    Content type: Research article

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  12. We evaluated the prognostic potential of tumor 18F-fluorodeoxyglucose (FDG) uptake derived from positron emission tomography (PET) and known inflammatory hematological markers, both individually and in combinatio...

    Authors: Kewei Zhao, Chunsheng Wang, Fang Shi, Yong Huang, Li Ma, Minghuan Li and Yipeng Song

    Citation: BMC Cancer 2021 21:66

    Content type: Research article

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  13. Chemoresistance is one of the main problems in treatment of cancer. Periostin (PN) is a stromal protein which is mostly secreted from cancer associated fibroblasts in the tumor microenvironment and can promote...

    Authors: Khine Kyaw Oo, Thanpawee Kamolhan, Anish Soni, Suyanee Thongchot, Chalermchai Mitrpant, Pornchai O-charoenrat, Chanitra Thuwajit and Peti Thuwajit

    Citation: BMC Cancer 2021 21:65

    Content type: Research article

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  14. Outcomes are poorer in metastatic colorectal cancer (mCRC) patients with BRAF V600E mutations than those without it, but the effect of these mutations on treatment response is unclear. This real-world study asses...

    Authors: Nieves Martínez-Lago, Ana Fernández-Montes, Marta Covela, Elena M. Brozos, Juan De la Cámara, José C. Méndez Méndez, Mónica Jorge-Fernández, Antía Cousillas Castiñeiras, Cristina Reboredo, David Arias Ron, María L. Pellón Augusto, Paula González Villarroel, Begoña Graña, Mercedes Salgado Fernández, Alberto Carral Maseda, Francisca Vázquez Rivera…

    Citation: BMC Cancer 2021 21:64

    Content type: Research article

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  16. The superior accuracy and sensitivity of 18F-FDG-PET/CT in comparison to morphological imaging alone leads to an upstaging in up to 30% of lymphoma patients. Novel digital PET/CT scanners might enable to reduce a...

    Authors: Manuel Weber, Walter Jentzen, Regina Hofferber, Ken Herrmann, Wolfgang Peter Fendler, Christoph Rischpler, Lale Umutlu, Maurizio Conti, Pedro Fragoso Costa, Miriam Sraieb and David Kersting

    Citation: BMC Cancer 2021 21:62

    Content type: Research article

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  17. Prostate cancer among black men is known to have specific molecular characteristics, especially the androgen receptor or enzymes related to the androgen metabolism. These targets are keys to the action of new ...

    Authors: Matthias E. Meunier, Pascal Blanchet, Yann Neuzillet, Thierry Lebret and Laurent Brureau

    Citation: BMC Cancer 2021 21:61

    Content type: Research article

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  19. The prognosis of childhood acute lymphoblastic leukemia (ALL) is optimistic with a 5-year event-free survival (EFS) rate of 70–85%. However, the major causes of mortality are chemotherapy toxicity, infection a...

    Authors: Xin-Yu Li, Jia-Qiang Li, Xue-Qun Luo, Xue-Dong Wu, Xin Sun, Hong-Gui Xu, Chang-Gang Li, Ri-Yang Liu, Xiao-Fei Sun, Hui-Qin Chen, Yu-Deng Lin, Chi-kong LI and Jian-Pei Fang

    Citation: BMC Cancer 2021 21:59

    Content type: Research article

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  20. Autophagy-related genes (ARGs) have been confirmed to have an important role in tumorigenesis and tumor microenvironment formation. Nevertheless, a systematic analysis of ARGs and their clinical significance i...

    Authors: Yuanhe Wang, Jianyi Li, Cheng Shao, Xiaojie Tang, Yukun Du, Tongshuai Xu, Zheng Zhao, Huiqiang Hu, Yingyi Sheng, Chuan Hu and Yongming Xi

    Citation: BMC Cancer 2021 21:58

    Content type: Research article

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  21. Cell-free DNA (cfDNA) genotyping in plasma using the cobas EGFR Mutation Test v2 (cobas) is the first liquid biopsy as a companion diagnosis to identify the EGFR T790M mutation (T790M) after the failure of tre...

    Authors: Yuko Oya, Tatsuya Yoshida, Kazuhiro Asada, Tetsuya Oguri, Naoki Inui, Sayako Morikawa, Kentaro Ito, Tomoki Kimura, Eiji Kunii, Takashi Matsui, Akihito Kubo, Tatsuo Kato, Takashi Abe, Takeshi Tsuda and Toyoaki Hida

    Citation: BMC Cancer 2021 21:57

    Content type: Research article

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  22. Surgery is the only treatment option for operable gastric cancer. The CLASSIC and ACTS-GC studies showed that the 5-year overall survival (OS) of patients with stage III gastric cancer undergoing D2 gastrectom...

    Authors: Xiangdong Cheng, Dan Wu, Nong Xu, Luchuan Chen, Zhilong Yan, Ping Chen, Lei Zhou, Jianfa Yu, Jiuwei Cui, Wei Li, Chang Wang, Wenming Feng, Yunhai Wei, Pengfei Yu, Yian Du, Jieer Ying…

    Citation: BMC Cancer 2021 21:56

    Content type: Study protocol

    Published on:

  25. Prognosis for pediatric metastatic Retinoblastoma (Rb) is poor and current therapies are limited by high systemic toxicity rates and insufficient therapeutic efficacy for metastatic Rb. Tumor dissemination to ...

    Authors: Jonathan Guihurt Santiago, Neikelyn Burgos-Tirado, Daniella Dorta Lafontaine, José C. Mendoza Sierra, Roberto Herrera Camacho, Clara M. Vecchini Rodríguez, Vanessa Morales-Tirado and Jacqueline Flores-Otero

    Citation: BMC Cancer 2021 21:53

    Content type: Research article

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  26. Epidermal growth factor receptor (EGFR) mutations in non–small-cell lung cancer predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs). EGFR mutation types are associated with efficacy of EGFR TKIs. We inv...

    Authors: Sojung Park, Sung Yong Lee, Dojin Kim, Yun Su Sim, Jeong-Seon Ryu, Juwhan Choi, Su Hwan Lee, Yon Ju Ryu, Jin Hwa Lee and Jung Hyun Chang

    Citation: BMC Cancer 2021 21:52

    Content type: Research article

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  27. Bladder cancer is the ninth most common type of cancer worldwide. In the past, radical cystectomy via open surgery has been considered the gold-standard treatment for muscle invasive bladder cancer. However, i...

    Authors: Angelo Porreca, Katie Palmer, Walter Artibani, Alessandro Antonelli, Lorenzo Bianchi, Eugenio Brunocilla, Aldo Massimo Bocciardi, Maurizio Brausi, Gian Maria Busetto, Marco Carini, Giuseppe Carrieri, Antonio Celia, Luca Cindolo, Giovanni Cochetti, Renzo Colombo, Ettore De Berardinis…

    Citation: BMC Cancer 2021 21:51

    Content type: Study protocol

    Published on:

  28. Despite much research published on lung cancer screening, China has had no large-scale study on the missed diagnosis of lung cancer in a health examination population. We therefore did a real-world study using...

    Authors: Guiyi Ji, Ting Bao, Zhenzhen Li, Huairong Tang, Dan Liu, Ping Yang, Weimin Li and Yan Huang

    Citation: BMC Cancer 2021 21:50

    Content type: Research article

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  29. Novel biomarkers and molecular monitoring tools hold potential to improve outcome for patients following resection of pancreatic ductal adenocarcinoma (PDAC). We hypothesized that the combined longitudinal ana...

    Authors: Saskia Hussung, Dilara Akhoundova, Julian Hipp, Marie Follo, Rhena F. U. Klar, Ulrike Philipp, Florian Scherer, Nikolas von Bubnoff, Justus Duyster, Melanie Boerries, Uwe Wittel and Ralph M. Fritsch

    Citation: BMC Cancer 2021 21:49

    Content type: Research article

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  30. Cisplatin-based chemotherapy is recommended as the primary treatment for advanced bladder cancer (BC) with unresectable or metastatic disease. However, the benefits are limited due to the acquisition of drug r...

    Authors: Shunsuke Okamura, Hirofumi Yoshino, Kazuki Kuroshima, Masafumi Tsuruda, Yoichi Osako, Takashi Sakaguchi, Masaya Yonemori, Yasutoshi Yamada, Shuichi Tatarano, Masayuki Nakagawa and Hideki Enokida

    Citation: BMC Cancer 2021 21:48

    Content type: Research article

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  31. Neoadjuvant chemotherapy (NACT) is the prime approach to the management of locally advanced breast cancer (LABC). Influenced by different factors such as pathologic tumor characteristics, hormone receptor stat...

    Authors: Dena Firouzabadi, Amirreza Dehghanian, Alireza Rezvani, Laleh Mahmoudi and Abdolrasoul Talei

    Citation: BMC Cancer 2021 21:47

    Content type: Research article

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  32. Although arsenic trioxide (ATO) and all-trans retinoic acid (ATRA) are well-tolerated and effective treatments for Acute Promyelocytic Leukemia (APL), Differentiation Syndrome (DS) is a lethal side effect in s...

    Authors: Zahra Mohammadzadeh, Azadeh Omidkhoda, Bahram Chahardouli, Ghazaleh Hoseinzadeh, Kamran Ali Moghaddam, Seyed Asadollah Mousavi and Shahrbano Rostami

    Citation: BMC Cancer 2021 21:46

    Content type: Research article

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  33. Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. Comparison of prognosis between LS and sporadic CRC (SCRC) were rare, with conflicting results. This study aimed to compare t...

    Authors: Yun Xu, Cong Li, Charlie Zhi-Lin Zheng, Yu-Qin Zhang, Tian-An Guo, Fang-Qi Liu and Ye Xu

    Citation: BMC Cancer 2021 21:45

    Content type: Research article

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  34. lncRNAs have important roles in regulating cancer biology. Accumulating evidence has established a link between the dysregulation of lncRNAs and microRNA in cancer progression. In previous studies, miR-7-5p has b...

    Authors: Gwan Woo Ku, Yujin Kang, Seong-Lan Yu, Joonghoon Park, Sejin Park, In Beom Jeong, Min Woong Kang, Ji Woong Son and Jaeku Kang

    Citation: BMC Cancer 2021 21:44

    Content type: Research article

    Published on:

  35. Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-a...

    Authors: Dominic O’Connor, Malcolm Brown, Martin Eatock, Richard C. Turkington and Gillian Prue

    Citation: BMC Cancer 2021 21:43

    Content type: Research article

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  36. In contrast to the rapid increase in thyroid cancer incidence, the mortality has remained low and stable over the last decades. In Ecuador, however, thyroid cancer mortality has increased. The objective of thi...

    Authors: Paola Solis-Pazmino, Jorge Salazar-Vega, Eddy Lincango-Naranjo, Cristhian Garcia, Gabriela Jaramillo Koupermann, Esteban Ortiz-Prado, Tannya Ledesma, Tatiana Rojas, Benjamin Alvarado-Mafla, Cesar Carcamo, Oscar J. Ponce and Juan P. Brito

    Citation: BMC Cancer 2021 21:42

    Content type: Research article

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  37. This study aimed to evaluate the impact of postoperative complications on long-term survival in patients with peritoneal metastasis (PM) arising from colorectal cancer (CRC) treated with cytoreductive surgery ...

    Authors: Sicheng Zhou, Qiang Feng, Jing Zhang, Haitao Zhou, Zheng Jiang, Zheng Liu, Zhaoxu Zheng, Haipeng Chen, Zheng Wang, Jianwei Liang, Wei Pei, Qian Liu, Zhixiang Zhou and Xishan Wang

    Citation: BMC Cancer 2021 21:41

    Content type: Research article

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  38. Rho-family GTPases, including Ras-related C3 botulinum toxin substrate 1 (Rac1) and cell division control protein 42 (Cdc42), are important modulators of cancer-relevant cell functions and are viewed as promis...

    Authors: Martha M. Grimes, S. Ray Kenney, Dayna R. Dominguez, Kathryn J. Brayer, Yuna Guo, Angela Wandinger-Ness and Laurie G. Hudson

    Citation: BMC Cancer 2021 21:40

    Content type: Research article

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  39. To improve the efficiency of early diagnosis systems for cervical cancer, the use of cellular and viral markers for identifying precancerous lesions with a greater probability to progress to cancer has been pr...

    Authors: Oscar Del Moral-Hernández, Daniel Hernández-Sotelo, Luz del Carmen Alarcón-Romero, Miguel Angel Mendoza-Catalán, Eugenia Flores-Alfaro, Yaneth Castro-Coronel, Julio Ortiz-Ortiz, Marco Antonio Leyva-Vázquez, Carlos Ortuño-Pineda, Wendy Castro-Mora and Berenice Illades-Aguiar

    Citation: BMC Cancer 2021 21:39

    Content type: Research article

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  40. Immune checkpoint inhibitors-induced myocarditis presents unique clinical challenges. Here, we assessed post-marketing safety of cytotoxic T-lymphocyte-associated protein-4 (CTLA-4), programmed cell death-1 (P...

    Authors: Rulan Ma, Quanziang Wang, Deyu Meng, Kang Li and Yong Zhang

    Citation: BMC Cancer 2021 21:38

    Content type: Research article

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  41. Our previous studies demonstrated that the administration of crude Polysaccharide from Panax notoginseng (CPPN) can effectively prolong the lifespan of tumor-bearing mice via boosting the host immune system as we...

    Authors: Yan-Hong Liu, Hua-Yan Qin, Yuan-Yuan Zhong, Shuang Li, Hua-Jing Wang, Hong Wang, Li-Ling Chen, Xiang Tang, Ya-Lin Li, Zhong-Yi Qian, Huai-Yu Li, Lei Zhang and Tong Chen

    Citation: BMC Cancer 2021 21:37

    Content type: Research article

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  42. Isocitrate dehydrogenase (IDH1/2) gene mutations are the most frequently observed mutations in cartilaginous tumors. The mutant IDH causes elevation in the levels of R-enantiomer of 2-hydroxylglutarate (R-2HG)...

    Authors: Lizhen Liu, Kaimin Hu, Jingjing Feng, Huafang Wang, Shan Fu, Binsheng Wang, Limengmeng Wang, Yulin Xu, Xiaohong Yu and He Huang

    Citation: BMC Cancer 2021 21:36

    Content type: Research article

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  43. The aim of our study was to evaluate the cost-effectiveness of cabazitaxel versus abiraterone or enzalutamide in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with do...

    Authors: Peng-Fei Zhang, Dan Xie and Qiu Li

    Citation: BMC Cancer 2021 21:35

    Content type: Research article

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  44. The Oral Care BC-trial reported that professional oral care (POC) reduces the incidence and severity of oral mucositis in patients receiving everolimus (EVE) and exemestane (EXE). However, the effect of POC on...

    Authors: Katsuhiko Nakatsukasa, Naoki Niikura, Kosuke Kashiwabara, Takeshi Amemiya, Ken-ichi Watanabe, Hironobu Hata, Yuichiro Kikawa, Naoki Taniike, Takashi Yamanaka, Sachiyo Mitsunaga, Kazuhiko Nakagami, Moriyasu Adachi, Naoto Kondo, Yasuyuki Shibuya, Naoki Hayashi, Mariko Naito…

    Citation: BMC Cancer 2021 21:34

    Content type: Research article

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  45. Anterior gradient-2 (AGR2) is a proto-oncogene involved in tumorigenesis and cancer progression. AGR2, predominantly localized in the endoplasmic reticulum (ER), is also a secreted protein detected in the extr...

    Authors: Xian Hong, Zhi-Xuan Li, Jie Hou, Hui-Yu Zhang, Chun-Yan Zhang, Jian Zhang, He Sun, Li-Hong Pang, Tao Wang and Zhi-Hui Deng

    Citation: BMC Cancer 2021 21:33

    Content type: Research article

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  46. Aberrant expression of P-cadherin has been reported in various cancers, and has been attracting attention as a target for cancer treatment. Ovarian cancer, the leading cause of death among gynecologic malignan...

    Authors: Kayo Kayahashi, Yasunari Mizumoto, Ayumi Matsuoka, Takeshi Obata, Junpei Iwadare, Mitsuhiro Nakamura, Takiko Daikoku and Hiroshi Fujiwara

    Citation: BMC Cancer 2021 21:32

    Content type: Research article

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  47. In recent years, the relationship between tumor-associated macrophages (TAMs) and solid tumors has become a research hotspot. This study aims to explore the close relationship of TAMs with metabolic reprogramm...

    Authors: Junyu Huo, Liqun Wu, Yunjin Zang, Hongjing Dong, Xiaoqiang Liu, Fu He and Xiao Zhang

    Citation: BMC Cancer 2021 21:31

    Content type: Research article

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  48. An upgraded understanding of factors (sex/estrogen) associated with survival benefit in advanced colorectal carcinoma (CRC) could improve personalised management and provide innovative insights into anti-tumou...

    Authors: Chunlong Huang, Xiaoyuan Gu, Xianshang Zeng, Baomin Chen, Weiguang Yu and Meiji Chen

    Citation: BMC Cancer 2021 21:30

    Content type: Research article

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  49. Endometrial cancer (EC) is one of the most common gynecological malignancies worldwide. However, the molecular mechanisms and the prognostic prediction for EC patients remain unclear.

    Authors: Jinhui Liu, Pinping Jiang, Xucheng Chen, Yujie Shen, Guoliang Cui, Ziyan Ma, Shaojie Zhao and Yan Zhang

    Citation: BMC Cancer 2021 21:29

    Content type: Research article

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  50. In people with albinism (PWA), the deficiency of melanin increase the risk of skin cancers. The aim of this study was to determine the prevalence of skin cancers and characteristics of these detected skin canc...

    Authors: Bayaki Saka, Sefako Abla Akakpo, Julienne Noude Teclessou, Piham Gnossike, Saliou Adam, Garba Mahamadou, Panawé Kassang, Yvette Elegbede, Abas Mouhari-Toure, Tchin Darre, Koussake Kombate and Palokinam Pitché

    Citation: BMC Cancer 2021 21:26

    Content type: Research article

    Published on:

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