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  1. Bladder cancer (BC) is one of the most common malignancies globally. Early diagnosis of it can significantly improve patients’ survival and quality of life. Urinary exosomes (UEs)-derived miRNAs might be a pro...

    Authors: Hao Lin, Xiaojun Shi, Haoran Li, Jialiang Hui, Ruiyu Liu, Zihao Chen, Yuwen Lu and Wanlong Tan

    Citation: BMC Cancer 2021 21:1293

    Content type: Research

    Published on:

  2. Cisplatin-based neoadjuvant chemotherapy (NAC) followed by surgery is the standard treatment for patients with non-metastatic muscle invasive bladder cancer (MIBC). Unfortunately, many patients are not candida...

    Authors: Nieves Martinez Chanza, Louisa Soukane, Philippe Barthelemy, Aurélien Carnot, Thierry Gil, Vinciane Casert, Vincent Vanhaudenarde, Brieuc Sautois, Lionel Staudacher, Jan Van den Brande, Stephane Culine, Emmanuel Seront, Marco Gizzi, Simone Albisinni, Thibault Tricard, Jean Christophe Fantoni…

    Citation: BMC Cancer 2021 21:1292

    Content type: Study protocol

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  3. Authors: Shebli Atrash, Philippe Thompson-Leduc, Ming-Hui Tai, Shuchita Kaila, Kathleen Gray, Isabelle Ghelerter, Marie-Hélène Lafeuille, Patrick Lefebvre and Adriana Rossi

    Citation: BMC Cancer 2021 21:1291

    Content type: Correction

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    The original article was published in BMC Cancer 2021 21:1207

  4. RNA cargo in exosomes, especially microRNAs (miRNAs), play an important role in the chemotherapy drug resistance of human cancers. However, the role and mechanism of exosomal miR-107 on multidrug resistance of...

    Authors: Lu Jiang, Yan Zhang, Linghui Guo, Chaoyang Liu, Pan Wang and Weihong Ren

    Citation: BMC Cancer 2021 21:1290

    Content type: Research

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  5. The role of circular RNAs (circRNAs) in the occurrence and development of gastric cancer (GC) has recently attracted increasing interest. The following study investigates the role of a newly discovered hsa_cir...

    Authors: Xin Xu, Shoulian Wang, Haibo Wang, Chunpeng Pan, Wenyan Yang and Jiwei Yu

    Citation: BMC Cancer 2021 21:1289

    Content type: Research

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  6. Breast cancer screening is currently predominantly based on mammography, tainted with the occurrence of both false positivity and false negativity, urging for innovative strategies, as effective detection of e...

    Authors: Kosmas V. Kepesidis, Masa Bozic-Iven, Marinus Huber, Nashwa Abdel-Aziz, Sharif Kullab, Ahmed Abdelwarith, Abdulrahman Al Diab, Mohammed Al Ghamdi, Muath Abu Hilal, Mohun R. K. Bahadoor, Abhishake Sharma, Farida Dabouz, Maria Arafah, Abdallah M. Azzeer, Ferenc Krausz, Khalid Alsaleh…

    Citation: BMC Cancer 2021 21:1287

    Content type: Research

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  7. Osteosarcoma (OS) is a differentiation disease caused by the genetic and epigenetic differentiation of mesenchymal stem cells into osteoblasts. OS is a common, highly malignant tumor in children and adolescent...

    Authors: Pei Zhang, Keteng Xu, Jingcheng Wang, Jiale Zhang and Huahong Quan

    Citation: BMC Cancer 2021 21:1285

    Content type: Research

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  8. The purpose of this phase II study was to evaluate the feasibility of hypofractionated radiotherapy (HFRT) with a dose of 36.5 Gy in 10 fractions in postmastectomy patients.

    Authors: Huayong Jiang, Lingling Meng, Huijuan Zhang, Xiangkun Dai, Qian Zhang, Zhongjian Ju, Wei Yu and Lin Ma

    Citation: BMC Cancer 2021 21:1284

    Content type: Research

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  9. Cancer stem cells (CSCs) drive tumor initiation and progression and participate in tumor chemoresistance. We recently discovered that oral squamous cell carcinoma (OSCC) cells that highly express CD10 (CD10H c...

    Authors: Yinfei Pu, Qingxiang Li, Yifei Wang, Le Xu, Qiao Qiao, Yuxing Guo and Chuanbin Guo

    Citation: BMC Cancer 2021 21:1283

    Content type: Research

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  10. The mean platelet volume/platelet count ratio (MPV/PC) ratio based on the preoperative peripheral MPV and PCcan be used to predict the prognosis of multiple malignant tumors.

    Authors: Qicheng Deng, Qifang Long, Yanan Liu, Zhujuan Yang, Yibei Du and Xin Chen

    Citation: BMC Cancer 2021 21:1282

    Content type: Research

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  11. The aim of this prospective phase II study was to evaluate the efficacy and safety of biweekly docetaxel plus androgen-deprivation therapy (ADT) in patients with metastatic castration-naïve prostate cancer (mC...

    Authors: Seonggyu Byeon, Hongsik Kim, Hwang Gyun Jeon, Seong Il Seo, Seong Soo Jeon, Hyun Moo Lee, Soon Il Lee and Se Hoon Park

    Citation: BMC Cancer 2021 21:1281

    Content type: Research

    Published on:

  12. Lymph node metastasis (LNM) status is an important prognostic factor that strongly influences the treatment decision of early gastric cancer (EGC). This study aimed to evaluate the pattern and clinical signifi...

    Authors: Wu Yanzhang, Li Guanghua, Zhou Zhihao, Wang Zhixiong and Wang Zhao

    Citation: BMC Cancer 2021 21:1280

    Content type: Research

    Published on:

  13. Pancreatic cancer risk is poorly quantified in relation to the temporal presentation of medical comorbidities and lifestyle. This study aimed to examine this aspect, with possible influence of demographics.

    Authors: Abu Z. M. Dayem Ullah, Konstantinos Stasinos, Claude Chelala and Hemant M. Kocher

    Citation: BMC Cancer 2021 21:1279

    Content type: Research article

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  14. Whereas there are many pharmacological interventions prescribed for patients with advanced anaplastic lymphoma kinase (ALK)- rearranged non-small cell lung cancer (NSCLC), comparative data between novel generatio...

    Authors: Hao-chuan Ma, Yi-hong Liu, Kai-lin Ding, Yu-feng Liu, Wen-jie Zhao, Yan-juan Zhu, Xue-song Chang, Ya-dong Chen, Zhen-zhen Xiao, Ya-ya Yu, Rui Zhou and Hai-bo Zhang

    Citation: BMC Cancer 2021 21:1278

    Content type: Research

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  15. Population-based patient reported outcome data in oesophageal cancer are rare. The main purpose of this study was to describe health-related quality of life (HRQOL) 1 year after the diagnosis of oesophageal ca...

    Authors: Berit Sunde, Mats Lindblad, Marlene Malmström, Jakob Hedberg, Pernilla Lagergren and Magnus Nilsson

    Citation: BMC Cancer 2021 21:1277

    Content type: Research

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  16. Cancer development is strictly correlated to composition and physical properties of the extracellular matrix. Particularly, a higher matrix stiffness has been demonstrated to promote tumor sustained growth. Ou...

    Authors: Changsong Wang, Xiaozhong Jiang, Bin Huang, Wenhao Zhou, Xiao Cui, Chenghong Zheng, Fenghao Liu, Jieling Bi, Yi Zhang, Hong Luo, Lin Yuan, Jianyong Yang and Yu Yu

    Citation: BMC Cancer 2021 21:1276

    Content type: Research

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  17. Most immune-related adverse event (irAE) patterns and treatment guidelines are based on western clinical data. We evaluated the incidence and patterns of irAEs in patients treated with immune-checkpoint inhibi...

    Authors: Nuttapong Ngamphaiboon, Suthinee Ithimakin, Teerada Siripoon, Nattaya Sintawichai and Virote Sriuranpong

    Citation: BMC Cancer 2021 21:1275

    Content type: Research

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  18. The present study compared the effectiveness and toxicity of two treatment modalities, namely radiotherapy combined with nimotuzumab (N) and chemoradiotherapy (CRT) in patients with locally recurrent nasophary...

    Authors: Jing-Feng Zong, Qian-Dong Liang, Qiong-Jiao Lu, Yu-Hong Liu, Han-Chuan Xu, Bi-Juan Chen, Qiao-Juan Guo, Yun Xu, Cai-Rong Hu, Jian-Ji Pan and Shao-Jun Lin

    Citation: BMC Cancer 2021 21:1274

    Content type: Research

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  19. Large-panel genomic tumor testing (GTT) is an emerging technology with great promise but uncertain clinical value. Previous research has documented variability in academic oncologists’ perceptions and use of G...

    Authors: Eric C. Anderson, Alexandra C. Hinton, Christine W. Lary, Anny T. H. R. Fenton, Andrey Antov, Emily Edelman, Petra Helbig, Kate Reed, Susan Miesfeldt, Christian A. Thomas, Michael J. Hall, J. Scott Roberts, Jens Rueter and Paul K. J. Han

    Citation: BMC Cancer 2021 21:1273

    Content type: Research

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  20. Current knowledge about the promotion of long-term physical activity (PA) maintenance in cancer survivors is limited. The aims of this study were to 1) determine the effect of self-regulatory BCTs on long-term...

    Authors: Anne-Sophie Mazzoni, Hannah L. Brooke, Sveinung Berntsen, Karin Nordin and Ingrid Demmelmaier

    Citation: BMC Cancer 2021 21:1272

    Content type: Research

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  21. Recent data has demonstrated that hypoxia drives an immunosuppressive tumour microenvironment (TME) via various mechanisms including hypoxia inducible factor (HIF)-dependent upregulation of programmed death li...

    Authors: Vicky Smith, Debayan Mukherjee, Sapna Lunj, Ananya Choudhury, Peter Hoskin, Catharine West and Tim Illidge

    Citation: BMC Cancer 2021 21:1271

    Content type: Research

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  22. Entinostat is an oral inhibitor of class I histone deacetylases intended for endocrine therapy-resistant patients with hormone receptor-positive (HR+) advanced or metastatic breast cancer (BC). We examined the...

    Authors: Norikazu Masuda, Kenji Tamura, Hiroyuki Yasojima, Akihiko Shimomura, Masataka Sawaki, Min-Jung Lee, Akira Yuno, Jane Trepel, Ryoko Kimura, Yozo Nishimura, Shigehira Saji and Hiroji Iwata

    Citation: BMC Cancer 2021 21:1269

    Content type: Research article

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  23. Radiomics may provide more objective and accurate predictions for extrahepatic cholangiocarcinoma (ECC). In this study, we developed radiomics models based on magnetic resonance imaging (MRI) and machine learn...

    Authors: Yong Tang, Chun Mei Yang, Song Su, Wei Jia Wang, Li Ping Fan and Jian Shu

    Citation: BMC Cancer 2021 21:1268

    Content type: Research article

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  24. Bladder cancer (BC) is one of the most common malignancies and has a relatively poor outcome worldwide. In this study, we attempted to construct a novel metabolism-related gene (MRG) signature for predicting t...

    Authors: Xiaotao Li, Shi Fu, Yinglong Huang, Ting Luan, Haifeng Wang and Jiansong Wang

    Citation: BMC Cancer 2021 21:1267

    Content type: Research

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  25. N6-methyladenine (m6A) is the most common modification of mRNA and IncRNA in higher organisms. m6A has been confirmed to be related to the formation and progression of tumors and m6A-related genes can be used as ...

    Authors: Jialin Qu, Li Wang, Man Jiang, Zhimin Wei, Guangming Fu and Xiaochun Zhang

    Citation: BMC Cancer 2021 21:1265

    Content type: Research

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  26. Realistic pre-treatment expectations are important and have been associated with post-treatment health related quality of life (HRQOL). Patient expectations are greatly influenced by physicians, as they are th...

    Authors: Anne L. Versteeg, Roxanne Gal, Raphaele Charest-Morin, Jorrit-Jan Verlaan, Hester Wessels, Charles G. Fisher and Helena M. Verkooijen

    Citation: BMC Cancer 2021 21:1263

    Content type: Research

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  27. Despite lower cancer incidence rates, cancer mortality is higher among rural compared to urban dwellers. Patient, provider, and institutional level factors contribute to these disparities. The overarching obje...

    Authors: Tuya Pal, Pamela C. Hull, Tatsuki Koyama, Phillip Lammers, Denise Martinez, Jacob McArthy, Emma Schremp, Ann Tezak, Anne Washburn, Jennifer G. Whisenant and Debra L. Friedman

    Citation: BMC Cancer 2021 21:1262

    Content type: Study protocol

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  28. Some studies have shown that Immune checkpoint inhibitors (ICIs) have a favorable efficacy in advanced triple negative breast cancer (TNBC) patients, but the results are controversial in neoadjuvant chemothera...

    Authors: Yuanfang Xin, Guoshuang Shen, Yonghui Zheng, Yumei Guan, Xingfa Huo, Jinming Li, Dengfeng Ren, Fuxing Zhao, Zhen Liu, Zitao Li and Jiuda Zhao

    Citation: BMC Cancer 2021 21:1261

    Content type: Research

    Published on:

  29. To determine whether additional chemotherapy after concurrent chemoradiation (CCRT) improves survival outcomes in patients with early cervical cancer who undergo radical hysterectomy (RH).

    Authors: Se Ik Kim, Jeong Yun Kim, Chan Woo Wee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Taek Sang Lee, Hye Won Jeon, Noh Hyun Park, Yong Sang Song and Tae Hun Kim

    Citation: BMC Cancer 2021 21:1260

    Content type: Research

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  30. Gonadotropin Releasing Hormones agonists (GnRH), which are first line treatment for metastatic prostate cancer (PCa), increase risk of type 2 diabetes mellitus (T2DM). This study aims to quantify the associati...

    Authors: E. Lin, Hans Garmo, Mieke Van Hemelrijck, Jan Adolfsson, Pär Stattin, Björn Zethelius and Danielle Crawley

    Citation: BMC Cancer 2021 21:1259

    Content type: Research

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  31. Studies have indicated that individuals taking aspirin have a reduced risk of cancers and have also established chemo-preventive benefit of aspirin in colorectal cancer. However, research on the association be...

    Authors: Min-Chun Chuang, Yao-Hsu Yang, Meng-Jer Hsieh, Yu-Ching Lin, Tsung-Ming Yang, Pau-Chung Chen and Ming-Szu Hung

    Citation: BMC Cancer 2021 21:1257

    Content type: Research

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  32. Bladder cancer (BLCA) typically has a poor prognosis due to high relapse and metastasis rates. A growing body of evidence indicates that N6-methyladenosine (m6A) and long non-coding RNAs (lncRNAs) play crucial...

    Authors: Tianming Ma, Xiaonan Wang, Lingfeng Meng, Xiaodong Liu, Jiawen Wang, Wei Zhang, Zijian Tian and Yaoguang Zhang

    Citation: BMC Cancer 2021 21:1256

    Content type: Research

    Published on:

  33. Fatty acid metabolism is reportedly associated with various cancers. However, the role of pretreatment serum free fatty acid (FFA) levels in diffuse large B-cell lymphoma (DLBCL) prognosis is still unclear, an...

    Authors: Liping Fan, Qiuyan Lin, Xiaoling Huang, Danhui Fu and Haobo Huang

    Citation: BMC Cancer 2021 21:1255

    Content type: Research article

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  34. Although perineural invasion (PNI) is well-known to be correlated with and able to predict lymph node metastasis (LNM) in oral squamous cell carcinoma (OSCC), the clinical and molecular correlation between PNI...

    Authors: Yu Zhang, Mingtao Chen, Zheqi Liu, Xu Wang and Tong Ji

    Citation: BMC Cancer 2021 21:1254

    Content type: Research

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  35. This study aimed to present the performance of the National Cancer Network’s (NCN) pilot program in the Lower Silesian Voivodeship (southwestern province of Poland with a population of 2,9 million in 2019), to...

    Authors: Łukasz Trembecki, Aleksandra Sztuder, Ireneusz Pawlak, Rafał Matkowski and Adam Maciejczyk

    Citation: BMC Cancer 2021 21:1252

    Content type: Research

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  36. Breast cancer surgery frequently causes deficiencies in shoulder functioning. The study pourpode is to identify risk factors for prolonged pain, reduction in function, and decrease in range of motion (ROM) in ...

    Authors: Ifat Klein, Leonid Kalichman, Noy Chen and Sergio Susmallian

    Citation: BMC Cancer 2021 21:1251

    Content type: Research article

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  37. In patients with papillary thyroid cancer (PTC), cervical lymph node metastasis (LNM) must be carefully assessed to determine the extent of lymph node dissection required and patient prognosis. Few studies att...

    Authors: Lei Ye, Lei Hu, Weiyong Liu, Yuanyuan Luo, Zhe Li, Zuopeng Ding, Chunmei Hu, Lin Wang, Yajuan Zhu, Le Liu, Xiaopeng Ma, Yuan Kong and Liangliang Huang

    Citation: BMC Cancer 2021 21:1250

    Content type: Research article

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  38. Glioblastoma is a fatal brain tumour with a poor patient survival outcome. Hypoxia has been shown to reprogram cells towards a stem cell phenotype associated with self-renewal and drug resistance properties. A...

    Authors: Lucy Wanjiku Macharia, Wanjiru Muriithi, Carlos Pilotto Heming, Dennis Kirii Nyaga, Veronica Aran, Marianne Wanjiru Mureithi, Valeria Pereira Ferrer, Attilio Pane, Paulo Niemeyer Filho and Vivaldo Moura-Neto

    Citation: BMC Cancer 2021 21:1248

    Content type: Research

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  39. Local ablative therapy (LAT) may be beneficial for patients with epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC) with oligo-residual disease after treatment with EGFR tyrosine k...

    Authors: Taichi Miyawaki, Hirotsugu Kenmotsu, Hiroaki Kodama, Naoya Nishioka, Eriko Miyawaki, Nobuaki Mamesaya, Haruki Kobayashi, Shota Omori, Ryo Ko, Kazushige Wakuda, Akira Ono, Tateaki Naito, Haruyasu Murakami, Keita Mori, Hideyuki Harada, Masahiro Endo…

    Citation: BMC Cancer 2021 21:1247

    Content type: Research

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  40. Atypical tumor response patterns during immune checkpoint inhibitor therapy pose a challenge to clinicians and investigators in immuno-oncology practice. This study evaluated tumor burden dynamics to identify ...

    Authors: Peiyi Xie, Hong Zheng, Haiyang Chen, Kaikai Wei, Ximin Pan, Qinmei Xu, Yongchen Wang, Changguan Tang, Olivier Gevaert and Xiaochun Meng

    Citation: BMC Cancer 2021 21:1246

    Content type: Research

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  41. The genetic changes underlying carcinogenesis in patients with risk factors of gallbladder carcinoma (GBC) remains controversial, especially in patients with pancreaticobiliary maljunction (PBM). This study ai...

    Authors: Satoshi Kawakami, Shinichi Takano, Mitsuharu Fukasawa, Hiroko Shindo, Ei Takahashi, Yoshimitsu Fukasawa, Hiroshi Hayakawa, Natsuhiko Kuratomi, Makoto Kadokura, Naohiro Hosomura, Hidetake Amemiya, Hiromichi Kawaida, Hiroshi Kono, Shinya Maekawa, Daisuke Ichikawa and Nobuyuki Enomoto

    Citation: BMC Cancer 2021 21:1245

    Content type: Research

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  42. The BOLT study for sonidegib, a Hedgehog pathway inhibitor (HHI) approved for patients with locally advanced basal cell carcinoma (laBCC) not amenable to curative surgery or radiotherapy, used modified Respons...

    Authors: Ralf Gutzmer, Caroline Robert, Carmen Loquai, Dirk Schadendorf, Nicholas Squittieri, Ramon Arntz, Serena Martelli and Reinhard Dummer

    Citation: BMC Cancer 2021 21:1244

    Content type: Research

    Published on:

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