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  1. Content type: Research article

    Prostate cancer-related morbidity is associated with its preferential spread to the bone. Although the molecular interactions between the bone microenvironment and cancer cells have been researched extensively...

    Authors: Haider Mussawy, Lennart Viezens, Malte Schroeder, Svenja Hettenhausen, Jördis Sündermann, Jasmin Wellbrock, Kai Kossow and Christian Schaefer

    Citation: BMC Cancer 2018 18:979

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  2. Content type: Research article

    The prognostic biomarker for patients undergoing curative liver metastasectomy for colorectal cancer (CRC) is lacking. The purpose was to investigate the prognostic role of a lack of CDX2 expression, which has...

    Authors: Yasuyuki Shigematsu, Kentaro Inamura, Noriko Yamamoto, Yoshihiro Mise, Akio Saiura, Yuichi Ishikawa, Shunji Takahashi and Hiroaki Kanda

    Citation: BMC Cancer 2018 18:980

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  3. Content type: Research article

    Application of dendritic cells (DC) for cancer immunotherapy involves tumor-associated immunogenic antigens for effective therapeutic strategies. The present study investigated whether DC co-cultured with auto...

    Authors: Tao Yang, Wenjun Zhang, Li Wang, Chunyan Xiao, Li Wang, Yi Gong, Dehong Huang, Bingling Guo, Qiying Li, Ying Xiang and Yingyu Nan

    Citation: BMC Cancer 2018 18:984

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  4. Content type: Study protocol

    The prognosis for pancreatic cancer remains poor despite diagnostic advances and treatments with new chemotherapeutic regimens. The five year survival rate remains below 3%. Consequently, there is an urgent ne...

    Authors: Cindy Canivet, Sophie Gourgou-Bourgade, Bertrand Napoléon, Laurent Palazzo, Nicolas Flori, Pierre Guibert, Guillaume Piessen, Dominique Farges-Bancel, Jean-François Seitz, Eric Assenat, Véronique Vendrely, Stéphanie Truant, Geoffroy Vanbiervliet, Philippe Berthelémy, Stéphane Garcia, Anne Gomez-Brouchet…

    Citation: BMC Cancer 2018 18:986

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  5. Content type: Research article

    Indirect evidence suggesting the immunosensitivity/immunogenicity of neuroblastoma is accumulating. The aims of this study were to investigate the immune landscape of neuroblastoma and to evaluate the in vivo ...

    Authors: Chiara Camisaschi, Salvatore Lorenzo Renne, Valeria Beretta, Francesca Rini, Rosalin Dolores Spagnuolo, Alessandra Tuccitto, Marta Giorgia Podda, Giorgio Parmiani, Licia Rivoltini, Paola Collini, Chiara Castelli and Roberto Luksch

    Citation: BMC Cancer 2018 18:983

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  6. Content type: Research article

    In ovarian cancer, the role of estrogen receptors (ERs), particularly of ERβ, being suggested as tumor suppressor in breast and prostate cancer, remains unclear. We examined the expression of nuclear and cytop...

    Authors: Susanne Schüler-Toprak, Florian Weber, Maciej Skrzypczak, Olaf Ortmann and Oliver Treeck

    Citation: BMC Cancer 2018 18:981

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  7. Content type: Research article

    Erlotinib is a drug used for the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer. Severe hepatotoxicity was observed in 4% to 31% of patients receiving erlotinib treatment prompting delay...

    Authors: Min Kyoung Kim, Jeong Yee, Yoon Sook Cho, Hong Won Jang, Ji Min Han and Hye Sun Gwak

    Citation: BMC Cancer 2018 18:988

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  8. Content type: Research article

    The impact of tumor size on prognosis for surgically treated patients with pancreatic ductal adenocarcinoma (PDAC) remains controversial. A systematic review and meta-analysis was performed to evaluate this is...

    Authors: Debang Li, Bin Hu, Yanming Zhou, Tao Wan and Xiaoying Si

    Citation: BMC Cancer 2018 18:985

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  9. Content type: Case report

    Sarcomas account for less than 1% of primary breast cancers, and breast angiosarcomas are responsible for only 0.05% of all breast malignancies. The male breast has the same potential for malignant transformat...

    Authors: Benedito Borges da Silva, Walberto Monteiro Neiva Eulálio Filho, Pedro Vitor Lopes Costa, Rozirene Araújo Silva, Ariton Mendes Conde Junior, Diego Cipriano Chagas, Mariella de Almeida Melo, Fidelis Manes Neto, Cleciton Braga Tavares, Edilson Carvalho de Sousa Júnior, Eid Gonçalves Coelho, Viriato Campelo, Luis Henrique Gebrim and Raimundo Gerônimo da Silva Junior

    Citation: BMC Cancer 2018 18:978

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  10. Content type: Research article

    Although peripheral blood-based parameters (PBBPs) are reported as prognostic indicators in patients with breast cancers, their utility has not been studied in human epidermal growth factor receptor 2 (HER2)-p...

    Authors: Kazuhiro Araki, Yoshinori Ito, Ippei Fukada, Kokoro Kobayashi, Yoshimasa Miyagawa, Michiko Imamura, Ayako Kira, Yuichi Takatsuka, Chiyomi Egawa, Hirofumi Suwa, Shinji Ohno and Yasuo Miyoshi

    Citation: BMC Cancer 2018 18:982

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  11. Content type: Research article

    Fibronectin (FN) is a high-molecular-weight glycoprotein component of the extracellular matrix involved in cell adhesion, migration, metastasis, proliferation and differentiation, as well as embryogenesis, wou...

    Authors: Jiefei Xiao, Weilin Yang, Bo Xu, Haoshuai Zhu, Jianyong Zou, Chunhua Su, Jian Rong, Tao Wang and Zhenguang Chen

    Citation: BMC Cancer 2018 18:976

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  12. Content type: Research article

    In our previous study, colorectal cancer (CRC) patients with active Mycobacterium tuberculosis (MTB) tolerated concurrent anti-cancer chemotherapy (anti-CCT) and anti-MTB chemotherapy. In this study, we retrospec...

    Authors: Tomonori Hirashima, Yoshitaka Tamura, Yuki Han, Shoji Hashimoto, Ayako Tanaka, Takayuki Shiroyama, Naoko Morishita, Hidekazu Suzuki, Norio Okamoto, Shinobu Akada, Makoto Fujishima, Yoshihisa Kadota, Kazuya Sakata, Akiko Nishitani, Satoru Miyazaki and Takayuki Nagai

    Citation: BMC Cancer 2018 18:975

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  13. Content type: Research article

    Adjuvant endocrine therapy undoubtedly prolongs the time to recurrence for patients with hormone-positive early breast cancer. Extended endocrine therapy to 10 years or longer has been expected to bring a grea...

    Authors: Li Li, Bingmei Chang, Xiaoyue Jiang, Xueke Fan, Yingrui Li, Teng Li, Shanshan Wu, Jun Zhang, Seyed Kariminia and Qin Li

    Citation: BMC Cancer 2018 18:977

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  14. Content type: Research article

    We developed a novel plasma amino acid profile-based index (API) to detect ovarian, uterine, cervical, and endometrial cancers. In this study, we aimed to evaluate whether abnormal API values could be normaliz...

    Authors: Yukio Suzuki, Aya Tokinaga-Uchiyama, Taichi Mizushima, Yasuyo Maruyama, Tae Mogami, Nahoko Shikata, Atsuko Ikeda, Hiroshi Yamamoto and Etsuko Miyagi

    Citation: BMC Cancer 2018 18:973

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  15. Content type: Research article

    Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for mucinous cystic neoplasm of the pancreas carries a potential risk of inducing peritoneal tumor cell dissemination. We investigated the diagnost...

    Authors: Rei Suzuki, Hiroki Irie, Tadayuki Takagi, Mitsuru Sugimoto, Naoki Konno, Yuki Sato, Ko Watanabe, Jun Nakamura, Shigeru Marubashi, Takuto Hikichi and Hiromasa Ohira

    Citation: BMC Cancer 2018 18:974

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  16. Content type: Case report

    Epidermal growth factor receptor (EGFR) gene alterations and amplification are frequently reported in cases of glioblastoma (GBM). However, EGFR-activating mutations that confer proven sensitivity to tyrosine kin...

    Authors: Lea Loriguet, Mony Chenda Morisse, Julie Dremaux, Louison Collet, Christophe Attencourt, Alexandre Coutte, Mathieu Boone, Henri Sevestre, Antoine Galmiche, Brigitte Gubler, Bruno Chauffert and Stephanie Trudel

    Citation: BMC Cancer 2018 18:964

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  17. Content type: Research article

    Conventional chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC) however it increases therapeutic resistance. In contrast, metronomic chemotherapy (MET) is based on frequent drug administ...

    Authors: Rong-Sheng Qin, Zhen-Hua Zhang, Neng-Ping Zhu, Fei Chen, Qian Guo, Hao-Wen Hu, Shao-Zhi Fu, Shan-Shan Liu, Yue Chen, Juan Fan and Yun-Wei Han

    Citation: BMC Cancer 2018 18:967

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  18. Content type: Research article

    Prior small studies have shown increased expression of sperm protein 17 (Sp17) in epithelial ovarian cancer (EOC) tissue and suggest Sp17 as a potential biomarker for EOC. However, how Sp17 expression varies w...

    Authors: Laurie L. Brunette, Paulette Y. Mhawech-Fauceglia, Lingyun Ji, Joseph G. Skeate, Heike E. Brand, Kate Lawrenson, Saloni Walia, Maurizio Chiriva-Internati, Susan Groshen, Lynda D. Roman, W. Martin Kast and Diane M. Da Silva

    Citation: BMC Cancer 2018 18:970

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  19. Content type: Research article

    Lapatinib has clinical efficacy in the treatment of trastuzumab-refractory HER2-positive breast cancer. However, a significant proportion of patients develop progressive disease due to acquired resistance to t...

    Authors: Alex J Eustace, Neil T Conlon, Martina S J McDermott, Brigid C Browne, Patrick O’Leary, Frankie A Holmes, Virginia Espina, Lance A Liotta, Joyce O’Shaughnessy, Clair Gallagher, Lorraine O’Driscoll, Sweta Rani, Stephen F Madden, Neil A O’Brien, Charles Ginther, Dennis Slamon…

    Citation: BMC Cancer 2018 18:965

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  20. Content type: Research article

    We report here a correlation analysis conducted along with a phase II trial assessing bevacizumab in combination with weekly paclitaxel.

    Authors: Loïc Lebellec, François Bertucci, Emmanuelle Tresch-Bruneel, Isabelle Ray-Coquard, Axel Le Cesne, Emmanuelle Bompas, Jean-Yves Blay, Antoine Italiano, Olivier Mir, Thomas Ryckewaert, Yves Toiron, Luc Camoin, Anthony Goncalves, Nicolas Penel and Marie-Cécile Le Deley

    Citation: BMC Cancer 2018 18:963

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  21. Content type: Research article

    Cancer/testis antigen MAGEC2 (also known as HCA587) is highly expressed in a wide variety of tumors and plays an active role in promoting growth and metastasis of tumor cells. However, little is known for the ...

    Authors: Xiao Song, Chengli Guo, Yutian Zheng, Ying Wang, Zhongtian Jin and Yanhui Yin

    Citation: BMC Cancer 2018 18:971

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  22. Content type: Research article

    Decrease in bone mineral density, osteoporosis development, bone toxicity and resulting insufficiency fractures as late effect of radiotherapy are not well known. Osteoporosis development related to radiothera...

    Authors: Gokhan Yaprak, Cengiz Gemici, Sule Temizkan, Sevim Ozdemir, Berfu Cinkit Dogan and Ozgur Ozan Seseogullari

    Citation: BMC Cancer 2018 18:972

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  23. Content type: Research article

    The current TNM staging system is far from perfect in predicting the survival of individual non-small cell lung cancer (NSCLC) patients. In this study, we aim to combine clinical variables and molecular biomar...

    Authors: Lei Liu, Minxin Shi, Zhiwei Wang, Haimin Lu, Chang Li, Yu Tao, Xiaoyan Chen and Jun Zhao

    Citation: BMC Cancer 2018 18:966

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  24. Content type: Case report

    Gastric gastrointestinal stromal tumor (GIST), intro-abdominal and retroperitoneal neoplasms are distinct tumors arising from different cell layers; therefore, coexistence of such tumors is relatively rare.

    Authors: Yong Zhou, Xu-Dong Wu, Quan Shi, Chuan-hai Xu and Jing Jia

    Citation: BMC Cancer 2018 18:968

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  25. Content type: Research article

    The prognostic role of neutrophil-to-lymphocyte ratio (NLR) has been proposed in head and neck squamous cell carcinoma (HNSCC). However, it is currently unclear which cutoff values of NLR could consistently an...

    Authors: Jae-Keun Cho, Myoung Woo Kim, Ick Soo Choi, Uk Yeol Moon, Min-Ji Kim, Insuk Sohn, Seonwoo Kim and Han-Sin Jeong

    Citation: BMC Cancer 2018 18:969

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  26. Content type: Research article

    The cellular effects of androgen are transduced through the androgen receptor, which controls the expression of genes that regulate biosynthetic processes, cell growth, and metabolism. Androgen signaling also ...

    Authors: Kasey Jividen, Katarzyna Z Kedzierska, Chun-Song Yang, Karol Szlachta, Aakrosh Ratan and Bryce M Paschal

    Citation: BMC Cancer 2018 18:960

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  27. Content type: Research article

    The use of stereotactic body radiotherapy (SBRT) for early-stage primary non-small cell lung cancer (NSCLC) reported excellent local control rates. But the optimal SBRT dose for oligometastatic lung tumors (OL...

    Authors: Xin Wang, Leonid Zamdborg, Hong Ye, Inga S. Grills and Di Yan

    Citation: BMC Cancer 2018 18:962

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  28. Content type: Case report

    Gastrointestinal symptoms occur in approximately 50% of patients with systemic lupus erythematous with low specificity. Although it is well established that colon cancer is one of the many gastrointestinal man...

    Authors: Junfeng Shi, Jianquan Fei, Qingqing Yi, Lijuan Shen, Boshun Wan, Yueyu Chen and Qing Chang

    Citation: BMC Cancer 2018 18:961

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  29. Content type: Research article

    Chemotherapy-induced oral mucositis impairs the quality of life. The difference in severity of oral mucositis between different anti-epidermal growth factor receptor (EGFR) antibodies combined with cytotoxic d...

    Authors: Satoshi Dote, Shoji Itakura, Kohei Kamei, Daiki Hira, Satoshi Noda, Yuka Kobayashi and Tomohiro Terada

    Citation: BMC Cancer 2018 18:957

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  30. Content type: Research article

    The prognosis of patients with epidermal growth factor receptor (EGFR) mutant adenocarcinoma of the lung (Mt) and EGFR wild-type adenocarcinoma (Wt) after complete resection of the lung differ; however, the mecha...

    Authors: Tetsuya Isaka, Haruhiko Nakayama, Hiroyuki Ito, Tomoyuki Yokose, Kouzo Yamada and Munetaka Masuda

    Citation: BMC Cancer 2018 18:959

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  31. Content type: Research article

    Paclitaxel induced peripheral neuropathy (PIPN) is a major debilitating side effect of paclitaxel in patients with breast cancer with no fully known mechanisms. The aim of the study was to find out the possibl...

    Authors: Zohreh Ghoreishi, Seyedali Keshavarz, Mohammad Asghari Jafarabadi, Zahra Fathifar, Karyn A Goodman and Ali Esfahani

    Citation: BMC Cancer 2018 18:958

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  32. Content type: Research article

    FIGHTDIGO study showed the feasibility and acceptability of handgrip strength (HGS) measure in routine in 201 consecutive patients with digestive cancer treated with ambulatory chemotherapy. The present study ...

    Authors: Damien Botsen, Marie-Amélie Ordan, Coralie Barbe, Camille Mazza, Marine Perrier, Johanna Moreau, Mathilde Brasseur, Yohann Renard, Barbara Taillière, Florian Slimano, Eric Bertin and Olivier Bouché

    Citation: BMC Cancer 2018 18:955

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  33. Content type: Research article

    Patients’ quality of life has become a major objective of care in oncology. At the same time, it has become the object of increasing interest by researchers, working with both quantitative and qualitative meth...

    Authors: Jordan Sibeoni, Camille Picard, Massimiliano Orri, Mathilde Labey, Guilhem Bousquet, Laurence Verneuil and Anne Revah-Levy

    Citation: BMC Cancer 2018 18:951

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  34. Content type: Study protocol

    Many studies have shown that lifestyle factors such as diet, physical activity are related to the incidence of cancer. However, there are few studies on the association between lifestyle factors and cancer pro...

    Authors: Yuri Mizota, Yukihide Kanemitsu, Shunsuke Tsukamoto, Dai Shida, Hiroki Ochiai and Seiichiro Yamamoto

    Citation: BMC Cancer 2018 18:953

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  35. Content type: Study protocol

    Oligometastases refer to a state of disease where cancer has spread beyond the primary site, but is not yet widely metastatic, often defined as 1–3 or 1–5 metastases in number. Stereotactic ablative radiothera...

    Authors: Robert Olson, Mitchell Liu, Alanah Bergman, Sonya Lam, Fred Hsu, Benjamin Mou, Tanya Berrang, Ante Mestrovic, Nick Chng, Derek Hyde, Quinn Matthews, Chad Lund, Daniel Glick, Howard Pai, Parminder Basran, Hannah Carolan…

    Citation: BMC Cancer 2018 18:954

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  36. Content type: Research article

    In the last decade, several tyrosine kinase inhibitors (TKIs), which disrupt pathways involved in the proliferation and tumorigenesis of thyroid cancer, have been extensively studied. Two different TKIs, lenva...

    Authors: Soo Young Kim, Seok-Mo Kim, Ho-Jin Chang, Bup-Woo Kim, Yong Sang Lee, Cheong Soo Park, Ki Cheong Park and Hang-Seok Chang

    Citation: BMC Cancer 2018 18:956

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  37. Content type: Research article

    The transcribed ultraconserved regions (T-UCRs) are a novel class of non-coding RNAs that are absolutely conserved across species and are involved in carcinogenesis in some cancers. However, the expression and...

    Authors: Yohei Sekino, Naoya Sakamoto, Keisuke Goto, Ririno Honma, Yoshinori Shigematsu, Thang Pham Quoc, Kazuhiro Sentani, Naohide Oue, Jun Teishima, Fumi Kawakami, Jose A Karam, Kanishka Sircar, Akio Matsubara and Wataru Yasui

    Citation: BMC Cancer 2018 18:952

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  38. Content type: Research article

    This study assessed the health related quality of life of family caregivers (FCs) of leukemia patients by using the health utility scores derived from the EuroQol five-dimensional (EQ-5D) questionnaire.

    Authors: Hongjuan Yu, Huan Zhang, Jinjin Yang, Chaojie Liu, Chengfang Lu, Hongbin Yang, Weidong Huang, Jin Zhou, Wenqi Fu, Linmei Shi, Yan Yan, Guoxiang Liu and Limin Li

    Citation: BMC Cancer 2018 18:950

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  39. Content type: Research article

    Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural dev...

    Authors: Sophie Elena McGrath, Nicola Annels, Thumuluru K. Madhuri, Anil Tailor, Simon A. Butler-Manuel, Richard Morgan, Hardev Pandha and Agnieszka Michael

    Citation: BMC Cancer 2018 18:943

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  40. Content type: Study protocol

    The safety of laparoscopic total gastrectomy (LTG) for the treatment of gastric cancer remains lack of clinical evidence. The Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group recently launched...

    Authors: Hongyong He, Haojie Li, Xiangqian Su, Ziyu Li, Peiwu Yu, Hua Huang, Changming Huang, Jianxin Ye, Yong Li, Jian Suo, Jiren Yu, Guoxin Li, Zekuan Xu, Gang Zhao, Hui Cao, Jiankun Hu…

    Citation: BMC Cancer 2018 18:944

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  41. Content type: Research article

    The analysis of tumour-infiltrating immune cells within patients’ tumour samples in colorectal cancer (CRC) has become an independent predictor of patient survival. The tumour microenvironment and the immune c...

    Authors: Ramón Cantero-Cid, José Casas-Martin, Enrique Hernández-Jiménez, Carolina Cubillos-Zapata, Aníbal Varela-Serrano, José Avendaño-Ortiz, Marta Casarrubios, Karla Montalbán-Hernández, Ignacio Villacañas-Gil, Laura Guerra-Pastrián, Begoña Peinado, Cristóbal Marcano, Luis A Aguirre and Eduardo López-Collazo

    Citation: BMC Cancer 2018 18:945

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  42. Content type: Research article

    Survival of esophageal cancer in Linzhou was seen to increase over the past few decades and is higher than the average level of China due to the implementation of comprehensive prevention and control measures....

    Authors: Shuzheng Liu, Lanwei Guo, Qiong Chen, Liang Yu, Bianyun Li, Xiaoqin Cao and Xibin Sun

    Citation: BMC Cancer 2018 18:949

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  43. Content type: Research article

    The rs2147578 C > G polymorphism in the long non-coding RNA gene Lnc-LAMC2–1:1 is associated with increased susceptibility to a few types of cancers. However, its role in neuroblastoma has not been evaluated yet.

    Authors: Tianyou Yang, Zhuorong Zhang, Jiao Zhang, Tianbao Tan, Jiliang Yang, Jing Pan, Chao Hu, Jiahao Li, Huimin Xia, Jing He and Yan Zou

    Citation: BMC Cancer 2018 18:948

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  44. Content type: Research article

    Immune checkpoint inhibitors (ICIs) have emerged as promising therapeutic agents in non-small cell lung cancer (NSCLC). However, the duration for which ICIs should be continued remains a clinical problem.

    Authors: Motoko Tachihara, Shunichi Negoro, Takako Inoue, Motohiro Tamiya, Yuki Akazawa, Takeshi Uenami, Yoshiko Urata, Yoshihiro Hattori, Akito Hata, Nobuyuki Katakami and Soichiro Yokota

    Citation: BMC Cancer 2018 18:946

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  45. Content type: Case report

    Chronic active Epstein-Barr virus (EBV) infection (CAEBV) of the T-/NK-cell type, systemic form is a rare and potentially life-threatening illness caused by persistent EBV infection. The highest incidence is f...

    Authors: Maxi Wass, Marcus Bauer, Roald Pfannes, Kerstin Lorenz, Andreas Odparlik, Lutz P Müller and Claudia Wickenhauser

    Citation: BMC Cancer 2018 18:941

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  46. Content type: Research article

    Coagulation and nutrition play important roles in cancer progression. The aim of the present study is to evaluate the prognostic value of the preoperative fibrinogen/albumin ratio (FAR) in surgical patients wi...

    Authors: Yao Liang, Wei Wang, Yi Que, Yuanxiang Guan, Wei Xiao, Cheng Fang, Xing Zhang and Zhiwei Zhou

    Citation: BMC Cancer 2018 18:942

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  47. Content type: Case report

    Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting p...

    Authors: András Folyovich, Viktória Varga, György Várallyay, Lajos Kozák, Mária Bakos, Erika Scheidl, Katalin Anna Béres-Molnár, Zita Kajdácsi and Dániel Bereczki

    Citation: BMC Cancer 2018 18:947

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  48. Content type: Research article

    Carcinogenesis and tumor growth are associated with chronic inflammation and the host immune system. Here, we investigated the clinical significance and relationship between tumor-infiltrating lymphocytes (TIL...

    Authors: Kwan Ho Lee, Eun Young Kim, Ji Sup Yun, Yong Lai Park, Sung-Im Do, Seoung Wan Chae and Chan Heun Park

    Citation: BMC Cancer 2018 18:938

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  49. Content type: Research article

    The tyrosine kinase inhibitor pazopanib is used for treatment of sarcoma. Recent studies have suggested that the use of pazopanib may lead to the development of pneumothorax, an unexpected adverse effect in pa...

    Authors: Bruce Sabath, Hasan A Muhammad, Amulya Balagani, David E Ost, Erik Vakil, Tahreem Ahmed, Macarena R Vial and Horiana B Grosu

    Citation: BMC Cancer 2018 18:937

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