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  1. Cervical cancer is a preventable disease, but it is a major public health problem despite having a good prognosis when diagnosed early. Although the Pap smear has led to huge drops in rates of cervical cancer ...

    Authors: Neila Pierote Gaspar Nascimento, Thais Borges Gally, Grasiely Faccin Borges, Luciene Cristina Gastalho Campos and Carla Martins Kaneto
    Citation: BMC Cancer 2022 22:862
  2. Tumor budding is associated with lymph node (LN) metastasis in submucosal colorectal cancer (CRC). However, the rate of LN metastasis associated with the number of tumor buds is unknown. Here, we determined th...

    Authors: Jeong-ki Kim, Ye-Young Rhee, Jeong Mo Bae, Jung Ho Kim, Seong-Joon Koh, Hyun Jung Lee, Jong Pil Im, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park and Gyeong Hoon Kang
    Citation: BMC Cancer 2022 22:861
  3. The adjuvant treatment with Aromatase Inhibitor (AI) is considered standard of care for postmenopausal breast cancer (BC) women with hormone receptor-positive (HR +), however, it often causes adverse effects s...

    Authors: Isis Danyelle Dias Custódio, Fernanda Silva Mazzutti Nunes, Mariana Tavares Miranda Lima, Kamila Pires de Carvalho, Débora Santana Alves, Juliana Freitas Chiaretto, Paula Philbert Lajolo Canto, Carlos Eduardo Paiva and Yara Cristina de Paiva Maia
    Citation: BMC Cancer 2022 22:860
  4. The KMT2A gene, formerly named the MLL gene, is rearranged (KMT2Ar) in 70–75% of infants, 5–6% of children and 10–15% of adult patients with B cell acute lymphoblastic leukemia (B-ALL). The outcome after chemothe...

    Authors: Jinquan Wen, Min Zhou, Yali Shen, Yueting long, Yuxia Guo, Lin Song and Jianwen Xiao
    Citation: BMC Cancer 2022 22:859
  5. Inflammatory parameters and Epstein–Barr virus (EBV) DNA status have been confirmed to be associated with prognosis in nasopharyngeal carcinoma (NPC) patients. However, there are few in-depth studies on the pr...

    Authors: Xiaofei Yuan, Hua Yang, Fangfang Zeng, Shiyu Zhou, Shuting Wu, Yue Yuan, Linchong Cui, Huiru Feng, Danfan Lin, Zilu Chen, Xiong Liu, Jing Chen and Fan Wang
    Citation: BMC Cancer 2022 22:858
  6. Liver cirrhosis is a well-known risk factor for hepatocellular carcinoma (HCC). However, some HCC cases can also originate from non-cirrhotic livers. The aim of this study was to identify key circular RNAs (ci...

    Authors: Hongyu Li, Liangliang Xu, Pengsheng Yi, Lian Li, Tao Yan, Liang Xie and Zhijun Zhu
    Citation: BMC Cancer 2022 22:857
  7. Active surveillance (AS) is one of the treatment methods for patients with small renal masses (SRMs; < 4 cm), including renal cell carcinomas (RCCs). However, some small RCCs may exhibit aggressive neoplastic ...

    Authors: Masato Yanagi, Tomonari Kiriyama, Jun Akatsuka, Yuki Endo, Hayato Takeda, Akifumi Katsu, Yuichiro Honda, Kyota Suzuki, Yoshihiro Nishikawa, Shunsuke Ikuma, Hikaru Mikami, Yuka Toyama, Go Kimura and Yukihiro Kondo
    Citation: BMC Cancer 2022 22:856
  8. Persistent high-risk (hr) human papillomavirus (HPV) infection is a necessary cause of cervical cancer. Cervical cancer is a major public health problem in Sub-Saharan Africa including South Africa. This study...

    Authors: Teboho Amelia Tiiti, Selokela Gloria Selabe, Johannes Bogers and Ramokone Lisbeth Lebelo
    Citation: BMC Cancer 2022 22:854
  9. High-sensitivity C-reactive protein (hs-CRP) levels and metabolic syndrome (MetS) are known to be associated with an increased incidence of different cancers. We aimed to evaluate the effect of MetS combined w...

    Authors: Mengmeng Song, Tong Liu, Hai Liu, Qi Zhang, Qingsong Zhang, Yiming Wang, Xiangming Ma, Liying Cao and Hanping Shi
    Citation: BMC Cancer 2022 22:853
  10. Tumor acidosis, a common phenomenon in solid cancers such as breast cancer, is caused by the abnormal metabolism of cancer cells. The low pH affects cells surrounding the cancer, and tumor acidosis has been sh...

    Authors: Yong-Jin Kwon, Eun-Bi Seo, Ae Jin Jeong, Song-Hee Lee, Kum Hee Noh, Sangsik Lee, Chung-Hyun Cho, Chang-Han Lee, Hyun Mu Shin, Hang-Rae Kim, Hyeong-Gon Moon and Sang-Kyu Ye
    Citation: BMC Cancer 2022 22:852
  11. Trials investigating neoadjuvant treatment with immune checkpoint inhibitors (ICI) in patients with melanoma have shown high clinical and pathologic response rates. Treatment with talimogene laherparepvec (T-V...

    Authors: Maartje W. Rohaan, Emma H. A. Stahlie, Viola Franke, Lisanne P. Zijlker, Sofie Wilgenhof, Vincent van der Noort, Alexander C. J. van Akkooi and John B. A. G. Haanen
    Citation: BMC Cancer 2022 22:851
  12. The pandemic disrupted society and health services through lockdowns and resource reallocation to care for COVID-19 patients. Reductions in numbers of cancer patients having surgery, being diagnosed pathologic...

    Authors: Helen Mitchell, Ben S. Alford, Simon O’Hare, Eamon O’Callaghan, Colin Fox and Anna T. Gavin
    Citation: BMC Cancer 2022 22:850
  13. Breast cancer is an umbrella term referring to a group of biologically and molecularly heterogeneous diseases originating from the breast. Globally, incidences of breast cancer has been increasing dramatically...

    Authors: Ping-Hung Liu, James Cheng-Chung Wei, Yu-Hsun Wang and Ming-Hsin Yeh
    Citation: BMC Cancer 2022 22:849
  14. While cancer outcomes have improved over time, in Northern Ireland they continue to lag behind those of many other developed economies. The role of comorbid conditions has been suggested as a potential contrib...

    Authors: Ciaran O’Neill, David W. Donnelly, Mark Harbinson, Therese Kearney, Colin R. Fox, Gerard Walls and Anna Gavin
    Citation: BMC Cancer 2022 22:847
  15. Whether hypokalemia can affect the short-term outcomes of CRC patients after radical surgery remains unclear. The purpose of this study was to investigate the impact of preoperative hypokalemia on the short-te...

    Authors: Bin Zhang, Xiao-Yu Liu, Bing Kang, Chao Yuan, Zi-Wei Li, Zheng-Qiang Wei and Dong Peng
    Citation: BMC Cancer 2022 22:846
  16. Although immune-checkpoint inhibitors (ICI) are overall promissory for cancer treatment, they entail, in some cases, an undesired side-effect called hyperprogressive-cancer disease (HPD) associated with accele...

    Authors: Daniela R. Montagna, Alejandra Duarte, Paula Chiarella, Bárbara Rearte, Oscar D. Bustuoabad, Mónica Vermeulen and Raúl A. Ruggiero
    Citation: BMC Cancer 2022 22:845
  17. Glioblastoma (GBM) is one of the deadliest cancers. Treatment options are limited, and median patient survival is only several months. Translation of new therapies is hindered by a lack of GBM models that full...

    Authors: Julia A. Schulz, Louis T. Rodgers, Richard J. Kryscio, Anika M.S. Hartz and Björn Bauer
    Citation: BMC Cancer 2022 22:844
  18. Glioblastoma (GB) is the most common and most aggressive malignant brain tumor. In understanding its resistance to conventional treatments, iron metabolism and related pathways may represent a novel avenue. As...

    Authors: Charlotte Roy, Sylvie Avril, Claire Legendre, Bénédicte Lelièvre, Honorine Vellenriter, Sébastien Boni, Jérôme Cayon, Catherine Guillet, Yannick Guilloux, Michel Chérel, François Hindré and Emmanuel Garcion
    Citation: BMC Cancer 2022 22:843
  19. Acute, catastrophic bleeding in patients with head and neck cancer (HNC) is challenging and also a burden for their families and frontline physicians. This study analyzed the risk factors for rebleeding and lo...

    Authors: Chih-Kai Wang, Che-Fang Ho, Kuang-Yu Niu, Chia-Chien Wu, Yun-Chen Chang, Chien-Han Hsiao and Chieh-Ching Yen
    Citation: BMC Cancer 2022 22:841
  20. Inflammatory indices and tumor-infiltrating lymphocytes (TILs) have prognostic value in many cancer types. This study aimed to assess the prognostic value of inflammatory indices and evaluate their correlation...

    Authors: Hiroki Kanno, Toru Hisaka, Jun Akiba, Kazuaki Hashimoto, Fumihiko Fujita and Yoshito Akagi
    Citation: BMC Cancer 2022 22:839
  21. Most recent laboratory studies have suggested a promising role of vitamin D and its analogs as novel chemotherapeutic agents for cancer treatment. However, epidemiological evidence, especially regarding the ef...

    Authors: Minh Thien Nguyen, Nhi Ngoc Yen Huynh, Dai Duc Nguyen, Nguyen Ha Ta, Tai Van Nguyen, Huy Thanh Dang and Ngoan Tran Le
    Citation: BMC Cancer 2022 22:838
  22. Despite benefits of endocrine therapy (ET) for patients with hormone-receptor (HR)-positive breast cancer, many patients do not initiate or discontinue ET against recommendations.

    Authors: Beomyoung Cho, Maria Pérez, Donna B. Jeffe, Matthew W. Kreuter, Julie A. Margenthaler, Graham A. Colditz and Ying Liu
    Citation: BMC Cancer 2022 22:837
  23. A deep understanding of potential molecular biomarkers and therapeutic targets related to the progression of colorectal cancer (CRC) from early stages to metastasis remain mostly undone. Moreover, the regulati...

    Authors: Pouria Samadi, Meysam Soleimani, Fatemeh Nouri, Fatemeh Rahbarizadeh, Rezvan Najafi and Akram Jalali
    Citation: BMC Cancer 2022 22:835
  24. Cancer-testis antigens (CTAs) have emerged as potential clinical biomarkers targeting immunotherapy. KK-LC-1 is a member of CTAs, which has been demonstrated in a variety of tumors tissues and been found to el...

    Authors: Yanli Kang, Yuhan Gan, Yingfeng Jiang, Jianbin You, Chen Huang, Qianshun Chen, Xunyu Xu, Falin Chen and Liangyuan Chen
    Citation: BMC Cancer 2022 22:834
  25. The amino acid transporter SLC6A14, which transports 18 of the 20 proteinogenic amino acids, is too low to be detected in healthy normal tissues but is significantly increased in some solid cancers. However, l...

    Authors: Ying Lu, Ziting Jiang, Kaijing Wang, Shanshan Yu, Chongbo Hao, Zuan Ma, Xuelian Fu, Ming Qing Qin, Zengguang Xu and Lieying Fan
    Citation: BMC Cancer 2022 22:833
  26. Enhanced recovery after surgery programs have reduced complications and shortened hospital stays after lung resection. This study aimed to determine whether video-assisted thoracoscopic surgery performed as a ...

    Authors: Guofei Zhang, Junqiang Fan, Zipu Yu, Ying Chai, Sai Zhang, Ming Wu and Gang Shen
    Citation: BMC Cancer 2022 22:832
  27. To evaluate the diagnostic value of adding human epididymis protein 4 (HE4), cancer antigen 125 (CA125) and risk of malignancy algorithm (ROMA) to ultrasound for detecting ovarian cancer in patients with a pel...

    Authors: Elena Ioana Braicu, Catherine Linn Krause, Uwe Torsten, Herbert Mecke, Rolf Richter, Lars Hellmeyer, Malgorzata Lanowska, Bodo Müller, Elisa Koch, Janine Boenneß-Zaloum, Kerstin Ames, Radoslav Chekerov, Kati Hasenbein, Mathias Zimmermann, Mandy Mangler, Frank Chen…
    Citation: BMC Cancer 2022 22:831
  28. Hepatocellular carcinoma (HCC) is one of the most lethal cancers, with a poor prognosis. Prognostic biomarkers for HCC patients are urgently needed. We aimed to establish a nomogram prediction system that comb...

    Authors: Renguo Guan, Jingwen Zou, Jie Mei, Min Deng and Rongping Guo
    Citation: BMC Cancer 2022 22:830
  29. Carboplatin is the backbone cytotoxic agent for many chemotherapy regimens for lung cancer. Dosing of carboplatin is complicated due to its relationship to renal function and narrow therapeutic index. Overesti...

    Authors: Seçkin Akgül, Bryan A. Chan and Peter M. Manders
    Citation: BMC Cancer 2022 22:829
  30. The efficacy of bevacizumab in non-small cell lung cancer (NSCLC) patients is unsatisfactory, and the selection of suitable patients is still challenging. Given the epigenetic modifications can contribute to a...

    Authors: Butuo Li, Chao Jiang, Yiyue Xu, Xinyu Fan, Linlin Yang, Bing Zou, Bingjie Fan and Linlin Wang
    Citation: BMC Cancer 2022 22:828
  31. The most frequently diagnosed primary brain tumor is glioblastoma (GBM). Nearly all patients experience tumor recurrence and up to 90% of which is local recurrence. Thus, increasing the therapeutic ratio of ra...

    Authors: Yun Guan, Mingyuan Pan, Jun Yang, Qiuxia Lu, Liangfu Han, Ying Liu, Jing Li, Huaguang Zhu, Xiu Gong, Guanghai Mei, Xiaoxia Liu, Li Pan, Jiazhong Dai, Yang Wang, Enmin Wang and Xin Wang
    Citation: BMC Cancer 2022 22:827
  32. The difference in epidemiological characteristics of breast cancer (BC) across countries is valuable for BC management and prevention. The study evaluated the up-to-date burden, trends, and risk factors of BC ...

    Authors: Na Liu, Da-Wei Yang, Yan-Xia Wu, Wen-Qiong Xue, Dan-Hua Li, Jiang-Bo Zhang, Yong-Qiao He and Wei-Hua Jia
    Citation: BMC Cancer 2022 22:826
  33. Authors: Vijayasarathy Ketavarapu, Vishnubhotla Ravikanth, Mitnala Sasikala, G. V. Rao, Ch. Venkataramana Devi, Prabhakar Sripadi, Murali Satyanarayana Bethu, Ramars Amanchy, H. V. V. Murthy, Stephen J. Pandol and D. Nageshwar Reddy
    Citation: BMC Cancer 2022 22:825

    The original article was published in BMC Cancer 2022 22:792

  34. ICIs have remarkably affected the treatment strategies for numerous malignancies, including lung cancer. However, only a fraction of patients experience durable responses to ICIs; thus, there is an urgent need...

    Authors: Zhenzhen Liu, Yuzhu Diao and Xiaoling Li
    Citation: BMC Cancer 2022 22:824
  35. As a transmembrane protein, C-type lectin-like receptor 2 (CLEC-2) is mainly expressed on platelets and released into plasma after platelet activation. Activated platelets participate in the regulation of inna...

    Authors: Xin Zhang, Jia-rui Yuan, Xin Wang, Shuang Fu, Rui-tao Wang and Guang-yu Wang
    Citation: BMC Cancer 2022 22:823
  36. Initial systemic therapy for patients with metastatic colorectal cancer (mCRC) is usually based on two- or three-drug chemotherapy regimens with fluoropyrimidine (5-fluorouracil (5-FU) or capecitabine), oxalip...

    Authors: G. Sommerhäuser, A. Kurreck, S. Stintzing, V. Heinemann, L. Fischer von Weikersthal, T. Dechow, F. Kaiser, M. Karthaus, I. Schwaner, M. Fuchs, A. König, C. Roderburg, I. Hoyer, M. Quante, A. Kiani, S. Fruehauf…
    Citation: BMC Cancer 2022 22:820
  37. U.S. professional organizations have provided conflicting recommendations on annual vs. biennial mammography screening. Potential harms of more frequent screening include increased anxiety and costs of false p...

    Authors: Vicky Ro, Tarsha Jones, Thomas Silverman, Julia E. McGuinness, Ashlee Guzman, Jacquelyn Amenta, Rita Kukafka and Katherine D. Crew
    Citation: BMC Cancer 2022 22:819
  38. The mTOR signaling pathway plays an important role in cancer. As a master regulator, the status of MTOR affects pathway activity and the efficacy of mTOR inhibitor therapy. However, little research has been perfo...

    Authors: Chenxing Wang, Batuer Aikemu, Yanfei Shao, Sen Zhang, Guang Yang, Hiju Hong, Ling Huang, Hongtao Jia, Xiao Yang, Minhua Zheng, Jing Sun and Jianwen Li
    Citation: BMC Cancer 2022 22:818
  39. Urothelial carcinoma (UC) is among the most prevalent malignancies. The muscle-invasive bladder cancer (MIBC) shows an invasive feature and has poor prognosis, while the non-muscle invasive bladder cancer (NMI...

    Authors: Qiongqiong Lin, Lu Pei, Zhiguang Zhao, Xiaoping Zhuang and Haide Qin
    Citation: BMC Cancer 2022 22:817
  40. The endothelial activation and stress index (EASIX) score has been reported to predict overall survival (OS) in hematological cancers. However, it has not been validated as a prognostic marker for diffuse larg...

    Authors: Sungwoo Park, Se-Il Go and Gyeong-Won Lee
    Citation: BMC Cancer 2022 22:816
  41. Renin-angiotensin system inhibitors (RASIs) are widely used in the treatment of hypertension. However, their impact on the outcome of the combined treatment of rectal cancer is poorly understood. The aim of th...

    Authors: Marcin Zeman, Władysław Skałba, Agata Małgorzata Wilk, Alexander Jorge Cortez, Adam Maciejewski and Agnieszka Czarniecka
    Citation: BMC Cancer 2022 22:815
  42. Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and the adoptive immunotherapy of which is worth studying. CD133, a kind of cancer stem cell (CSC) antigen, together with glypican-3 (...

    Authors: Hezhi Wang, Xiaoxiao Wang, Xueshuai Ye, Yi Ju, Nana Cao, Shuqi Wang and Jianhui Cai
    Citation: BMC Cancer 2022 22:814
  43. Authors: Yozo Mitsui, Inik Chang, Shinichiro Fukuhara, Miho Hiraki, Naoko Arichi, Hiroaki Yasumoto, Hiroshi Hirata, Soichiro Yamamura, Varahram Shahryari, Guoren Deng, Darryn K. Wong, Shahana Majid, Hiroaki Shiina, Rajvir Dahiya and Yuichiro Tanaka
    Citation: BMC Cancer 2022 22:813

    The original article was published in BMC Cancer 2015 15:942

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