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  1. Distant metastasis remains the main cause of death in breast cancer. Breast cancer risk is strongly influenced by pathogenic mutation.This study was designed to develop a multiple-feature model using clinicopa...

    Authors: Zhenzhen Shao, Jinpu Yu, Yanan Cheng, Wenjuan Ma, Peifang Liu and Hong Lu
    Citation: BMC Cancer 2023 23:97
    Content type: Research Published on:

  2. High expression of SETD1A, a histone methyltransferase that specifically methylates H3K4, acted as a key oncogene in several human cancers. However, the function and underlying molecular mechanism of SETD1A in...

    Authors: Hongjuan Chai, Chunpeng Pan, Mingyang Zhang, Haizhong Huo, Haiyan Shan and Jugang Wu
    Citation: BMC Cancer 2023 23:96
    Content type: Research Published on:

  3. To evaluate the overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) for primary cervical lymphoma (PCL), an extremely rare disease without treatment consensus.

    Authors: Lingyun Gao, Xiaoran Chen, Jing Zhao, Anli Xu, Meijuan Liu, Hongna Yu, Shujun Kong and Sijian Li
    Citation: BMC Cancer 2023 23:95
    Content type: Research Published on:

  4. PRECONNECT was an international, phase IIIb trial evaluating the safety and efficacy of trifluridine/tipiracil (FTD/TPI) for metastatic colorectal cancer (mCRC).

    Authors: Julien Taieb, Timothy Price, Loïck Vidot, Bénédicte Chevallier, Lucjan Wyrwicz and Jean-Baptiste Bachet
    Citation: BMC Cancer 2023 23:94
    Content type: Research Published on:

  5. This retrospective study explored the relationship between hormone receptor (HR), human epidermal growth factor receptor 2 (HER2) status, and bone involvement in the first distant metastases (DM) of Chinese br...

    Authors: Zhifeng Jia, Muwei Dai, Yuguang Shang, Yue Li and Zhensheng Li
    Citation: BMC Cancer 2023 23:93
    Content type: Research Published on:

  6. Understanding the latest global spatio-temporal pattern of prostate cancer burden attributable to smoking can help guide effective global health policy. This study aims to elucidate the trends in smoking-relat...

    Authors: Hanfei Zhang, Dingping Huang, Yingfeng Zhang, Xia Wang, Jiangtao Wu and Daqing Hong
    Citation: BMC Cancer 2023 23:92
    Content type: Research Published on:

  9. Ovarian cancer is a leading cause of female mortality. Epigenetic changes occur in early stages of carcinogenesis and represent a marker for cancer diagnosis. Protocadherin 17 (PCDH17) is a tumor suppressor gene ...

    Authors: Sherif Mohamed Elsharkawi, Dalal Elkaffash, Pacint Moez, Nour El-Etreby, Eman Sheta and Raghda Saad Zaghloul Taleb
    Citation: BMC Cancer 2023 23:89
    Content type: Research Published on:

  10. Magnetic resonance imaging (MRI) performs well in the locoregional assessment of extranodal nasal-type NK/T-cell lymphoma (ENKTCL). It’s important to assess the value of multi-modal MRI-based radiomics for est...

    Authors: Yu-Ting Zhao, Si-Ye Chen, Xin Liu, Yong Yang, Bo Chen, Yong-Wen Song, Hui Fang, Jing Jin, Yue-Ping Liu, Hao Jing, Yuan Tang, Ning Li, Ning-Ning Lu, Shu-Lian Wang, Han Ouyang, Chen Hu…
    Citation: BMC Cancer 2023 23:88
    Content type: Research Published on:

  11. Insulin-like growth factor-1 receptor (IGF-1R) promotes cell proliferation and migration and inhibitsapoptosis, all of which can contribute to the development of cancers.

    Authors: Wenpeng Cai, Yongfang Ma, Li Song, Niandie Cao, Jiafeng Gao, Shuping Zhou and Xiaolong Tang
    Citation: BMC Cancer 2023 23:87
    Content type: Research Published on:

  12. Tumor micronecrosis is a histopathological feature predicting poor prognosis in patients with hepatocellular carcinoma (HCC) who underwent liver resection. However, the role of tumor micronecrosis in liver tra...

    Authors: Yangyang Wang, Wei Zhang, Hongbin Ge, Xu Han, Jiangchao Wu, Xuqi Sun, Ke Sun, Wanyue Cao, Chao Huang, Jingsong Li, Qi Zhang and Tingbo Liang
    Citation: BMC Cancer 2023 23:86
    Content type: Research Published on:

  13. While molecular targeted drugs and other therapies are being developed for many tumors, pancreatic cancer is still considered to be the malignant tumor with the worst prognosis. We started this study to identi...

    Authors: Shoichiro Tange, Tomomi Hirano, Masashi Idogawa, Eishu Hirata, Issei Imoto and Takashi Tokino
    Citation: BMC Cancer 2023 23:85
    Content type: Research Published on:

  14. Breast cancer patients of American Society of Clinical Oncology and the College of American Pathologists (ASCO/CAP) Group 2 were all HER2-negative according to the 2018 guideline, not HER2-positive as defined ...

    Authors: Shuling Zhou, Hong Lv, Anqi Li, Ming Li, Siyuan Zhong, Hongfen Lu, Xiaoyan Zhou, Qianming Bai and Wentao Yang
    Citation: BMC Cancer 2023 23:84
    Content type: Research Published on:

  15. Programmed Cell Death-1/ Programmed Death-ligand 1 (PD-1 / PD-L1) inhibitor therapies targeting immunocytes induce persistent tumor remission in various cancers. However, the appropriate biomarkers for the the...

    Authors: Xiaoyue Du, Shaodi Wen, Run Shi, Jingwei Xia, Ruotong Wang, Yihan Zhang, Banzhou Pan, Xiaoliu Wu, Wei Zhu, Jifeng Feng, Xin Wang and Bo Shen
    Citation: BMC Cancer 2023 23:83
    Content type: Research Published on:

  16. Mastocytosis is a very rare disorder and is divided into three prognostically distinct variants by World Health Organization: Cutaneous mastocytosis (CM), systemic mastocytosis (SM), and mast cell sarcoma or l...

    Authors: Tarık Onur Tiryaki, Sıdıka Gülkan Özkan, Simge Erdem, Aynur Dağlar Aday, İpek Yönal Hindilerden, Aslı Gelincik, Can Baykal, Gülçin Yegen, İbrahim Öner Doğan, Nesimi Büyükbabani, Meliha Nalçacı and Akif Selim Yavuz
    Citation: BMC Cancer 2023 23:82
    Content type: Research Published on:

  17. Childhood cancer (CC) is a leading cause of death among children aged 0–19 years worldwide. Each year, 400,000 new cases of CC are diagnosed globally. Given the between-country differences in CC incidence rate...

    Authors: Manushak Avagyan, Anahit Demirchyan and Lusine Abrahamyan
    Citation: BMC Cancer 2023 23:81
    Content type: Research Published on:

  18. Smoking is a modifiable risk factor for cancers. The aim of the study is to estimate the trend of mortality and DALYs of smoking-attributed cancers in the North Africa and Middle East (NAME) countries.

    Authors: Leila Rezakhani, Mitra Darbandi, Zahra Khorrami, Shima Rahmati and Fatemeh Khosravi Shadmani
    Citation: BMC Cancer 2023 23:80
    Content type: Research Published on:

  19. Cervical cancer is currently estimated to be the fourth most common cancer among women worldwide and the leading cause of cancer-related deaths in some of the world’s poorest countries. C/EBPβ has tumor suppre...

    Authors: Haichen Long, Yangyang Li, Huijuan Wang, Bingxuan Guo, Shuyan Song, Xiangyi Zhe, Hongtao Li, Dongmei Li, Renfu Shao and Zemin Pan
    Citation: BMC Cancer 2023 23:79
    Content type: Research Published on:

  20. Incidence and risk factors for seizures among women with advanced breast cancer (BC) and brain metastases are not well characterized across treatment-related or clinical subtypes. This study leveraged a large ...

    Authors: Alexander Liede, Wendy Sebby, Ashok Kumar Reddy Miriyala, Ravi Potluri, Debasish Mazumder, Anirban Ghosh, Eros Papademetriou, Ryan Kilpatrick and Jerzy E. Tyczynski
    Citation: BMC Cancer 2023 23:78
    Content type: Research Published on:

  21. Precision medicine with gene panel testing based on next-generation sequencing for patients with cancer is being used increasingly in clinical practice. HER2, which encodes the human epidermal growth factor recep...

    Authors: Yohei Harada, Akemi Sato, Hideaki Nakamura, Keita Kai, Sho Kitamura, Tomomi Nakamura, Yuki Kurihara, Sadakatsu Ikeda, Eisaburo Sueoka, Shinya Kimura and Naoko Sueoka-Aragane
    Citation: BMC Cancer 2023 23:77
    Content type: Research Published on:

  22. Gastric cancer peritoneal metastasis (GCPM) is an important cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs) play a key role in the regulation of GCPM, but the underlying mechanisms hav...

    Authors: Chao Dong, Fujuan Luan, Wenyan Tian, Kaipeng Duan, Tao Chen, Jiayu Ren, Weikang Li, Dongbao Li, Qiaoming Zhi and Jin Zhou
    Citation: BMC Cancer 2023 23:76
    Content type: Research Published on:

  24. Patients with follicular lymphoma (FL) can have high response rates to early lines of treatment. However, among FL patients relapsed/refractory (r/r) after ≥2 prior lines of therapy (LOT), remission tends to b...

    Authors: Steve Kanters, Graeme Ball, Brad Kahl, Adriana Wiesinger, Eve H. Limbrick-Oldfield, Akshay Sudhindra, Julia Thornton Snider and Anik R. Patel
    Citation: BMC Cancer 2023 23:74
    Content type: Research Published on:

  25. Stereotactic Body Radiation Therapy (SBRT) has been found beneficial for adrenal gland metastases (AGMs) with a high local control rate and low toxicity. The role of SBRT for AGMs in patients with liver cancer...

    Authors: Bichun Xu, Xianzhi Zhao, Di Chen, Wenjuan Zhao, Xiaoyan Wang, Changhua Ding, Zhiyong Yuan and Huojun Zhang
    Citation: BMC Cancer 2023 23:73
    Content type: Research Published on:

  26. “Anti-angiogenetic drugs plus chemotherapy” (anti-angio-chemo) and “immune checkpoint inhibitors plus chemotherapy” (ICI-chemo) are superior to traditional chemotherapy in the first-line treatment of patients ...

    Authors: Lan-Lan Pang, Jia-Di Gan, Yi-Hua Huang, Jun Liao, Wei-Tao Zhuang, Wael-Abdullah-Sultan Ali, Shao-Dong Hong, Li Zhang and Wen-Feng Fang
    Citation: BMC Cancer 2023 23:72
    Content type: Research article Published on:

  27. Chronic infection with Kaposi’s sarcoma-associated herpes virus (KSHV) in B lymphocytes causes primary effusion lymphoma (PEL), the most aggressive form of KSHV-related cancer, which is resistant to convention...

    Authors: Tetsunori Sakamoto, Masahiko Ajiro, Akira Watanabe, Shingo Matsushima, Keiji Ueda and Masatoshi Hagiwara
    Citation: BMC Cancer 2023 23:71
    Content type: Research Published on:

  28. Authors: D. Doppenberg, M. G. Besselink, C. H. J. van Eijck, M. P. W. Intven, B. Groot Koerkamp, G. Kazemier, H. W. M. van Laarhoven, M. Meijerink, I. Q. Molenaar, J. J. M. E. Nuyttens, R. van Os, H. C. van Santvoort, G. van Tienhoven, H. M. Verkooijen, E. Versteijne, J. W. Wilmink…
    Citation: BMC Cancer 2023 23:70
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2022 22:1363

  29. The initial management of patients with sarcoma is a critical issue. We used the nationwide French National Cancer Institute-funded prospective sarcoma database NETSARC to report the management and oncologic outc...

    Authors: Pierre Kubicek, Axel Le Cesne, Cyril Lervat, Maud Toulmonde, Christine Chevreau, Florence Duffaud, Louis-Romée Le Nail, Magali Morelle, Nathalie Gaspar, Cécile Vérité, Marie-Pierre Castex, Nicolas Penel, Esma Saada, Sylvain Causeret, François Bertucci, Christophe Perrin…
    Citation: BMC Cancer 2023 23:69
    Content type: Research Published on:

  30. Nanoliposomal irinotecan plus fluorouracil/leucovorin (5-FU/LV) is a standard second-line therapy for patients with pancreatic cancer. Identification of biomarkers is important to determine appropriate treatme...

    Authors: Takeshi Kawakami, Akiko Todaka, Kotoe Oshima, Kunihiro Fushiki, Satoshi Hamauchi, Takahiro Tsushima, Tomoya Yokota, Yusuke Onozawa, Hirofumi Yasui and Kentaro Yamazaki
    Citation: BMC Cancer 2023 23:68
    Content type: Research Published on:

  31. Little is known about dementia’s impact on patterns of diagnosis, treatment, and outcomes in cancer patients. This study aimed to elucidate the differences in cancer staging, treatment, and mortality in older ...

    Authors: Toshitaka Morishima, Yoshihiro Kuwabara, Mari Kajiwara Saito, Satomi Odani, Haruka Kudo, Mizuki Kato, Kayo Nakata and Isao Miyashiro
    Citation: BMC Cancer 2023 23:67
    Content type: Research article Published on:

  32. Historically, high hepatocellular carcinoma (HCC)–related mortality has been, in part, due to lack of effective therapies; however, several systemic therapies have been recently approved for HCC treatment, inc...

    Authors: Neehar D. Parikh, Allicia Girvan, Joshua Coulter, Jonathon Gable, Jiat Ling Poon, Sangmi Kim, Anindya Chatterjee and Marco Boeri
    Citation: BMC Cancer 2023 23:66
    Content type: Research Published on:

  33. Advances in multiple myeloma treatment and a proliferation of treatment options have resulted in improved survival rates and periods of symptom-free remission for many multiple myeloma patients. As a result, h...

    Authors: Carrie Dombeck, Teresa Swezey, Juan Marcos Gonzalez Sepulveda, Bryce B. Reeve, Thomas W. LeBlanc, David Chandler and Amy Corneli
    Citation: BMC Cancer 2023 23:65
    Content type: Research Published on:

  34. Peritoneal metastasis (PM) is not uncommon in patients with gastric cancer(GC), which affects clinical treatment decisions, but the relevant examination measures are not efficiently detected. Our goal was to d...

    Authors: Jia Yang, Hongtao Su, Tao Chen, Xinhua Chen, Hao Chen, Guoxin Li and Jiang Yu
    Citation: BMC Cancer 2023 23:64
    Content type: Research Published on:

  35. Duke pancreatic mono-clonal antigen type 2 (DUPAN-II) is a famous tumour maker for pancreatic cancer (PC) as well as carbohydrate antigen 19–9 (CA19-9). We evaluated the clinical implications of DUPAN-II level...

    Authors: Shinichiro Hasegawa, Hidenori Takahashi, Hirofumi Akita, Yosuke Mukai, Manabu Mikamori, Kei Asukai, Daisaku Yamada, Hiroshi Wada, Yoshiaki Fujii, Takahito Sugase, Masaaki Yamamoto, Tomohira Takeoka, Naoki Shinno, Hisashi Hara, Takashi Kanemura, Naotsugu Haraguchi…
    Citation: BMC Cancer 2023 23:63
    Content type: Research Published on:

  36. Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that converts tryptophan to kynurenine. IDO1 expression is found not only in tumor cells but also in immune cells and is associated with tumor proliferation an...

    Authors: Hiroaki Nozawa, Tetsuro Taira, Hirofumi Sonoda, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Yuzo Nagai, Shinya Abe and Soichiro Ishihara
    Citation: BMC Cancer 2023 23:62
    Content type: Research Published on:

  37. Preoperative assessment of lymphovascular invasion(LVI) of rectal cancer has very important clinical significance. However, accurate preoperative imaging evaluation of LVI is highly challenging because the res...

    Authors: Pengfei Tong, Danqi Sun, Guangqiang Chen, Jianming Ni and Yonggang Li
    Citation: BMC Cancer 2023 23:61
    Content type: Research Published on:

  38. Colorectal cancer is the third most diagnosed cancer globally and the second leading cause of cancer death. We examined colon and rectal cancer treatment patterns in Australia.

    Authors: Sarsha Yap, Emily He, Sam Egger, David E Goldsbury, Jie-Bin Lew, Preston J Ngo, Joachim Worthington, Hannah Rillstone, John R Zalcberg, Jeff Cuff, Robyn L Ward, Karen Canfell, Eleonora Feletto and Julia Steinberg
    Citation: BMC Cancer 2023 23:60
    Content type: Research Published on:

  39. Saroglitazar is a novel PPAR-α/γ agonist with predominant PPAR-α activity. In various preclinical models, saroglitazar has been shown to prevent & reverse symptoms of NASH. In view of these observations, and t...

    Authors: Suresh R. Giri, Bibhuti Bhoi, Chitrang Trivedi, Akshyaya Rath, Rohan Rathod, Anish Sharma, Ramchandra Ranvir, Shekhar Kadam, Kailash Ingale, Hiren Patel, Abraham Nyska and Mukul R. Jain
    Citation: BMC Cancer 2023 23:59
    Content type: Research Published on:

  40. CT is the major detection tool for pancreatic cancer (PC). However, approximately 40% of PCs < 2 cm are missed on CT, underscoring a pressing need for tools to supplement radiologist interpretation.

    Authors: Dawei Chang, Po-Ting Chen, Pochuan Wang, Tinghui Wu, Andre Yanchen Yeh, Po-Chang Lee, Yi-Hui Sung, Kao-Lang Liu, Ming-Shiang Wu, Dong Yang, Holger Roth, Wei-Chih Liao and Weichung Wang
    Citation: BMC Cancer 2023 23:58
    Content type: Research Published on:

  41. Circadian clock genes are significant in the occurrence and development of HCC and long-non coding RNAs (lncRNAs) are closely related to HCC progression. In this study, we aimed to establish a prognostic risk ...

    Authors: Zhen Zhang, Wenhui Gao, Xiaoning Tan, Tianhao Deng, Wanshuang Zhou, Huiying Jian and Puhua Zeng
    Citation: BMC Cancer 2023 23:57
    Content type: Research Published on:

  42. Computed tomography (CT) derived body composition measurements of sarcopenia are an emerging form of prognostication in many disease processes. Although the L3 vertebral level is commonly used to measure skel...

    Authors: Aisha A Arayne, Richard Gartrell, Jing Qiao, Paul N Baird and Justin MC Yeung
    Citation: BMC Cancer 2023 23:56
    Content type: Research Published on:

  43. Macrophage infiltration in the tumor microenvironment participates in the regulation of tumor progression. Previous studies have found that Notch signaling pathway is involved in regulating the progression of ...

    Authors: Kai Huang, Wenwu Luo, Jinmei Fang, Changjun Yu, Guangjie Liu, Xiaodong Yuan, Yun Liu and Wenyong Wu
    Citation: BMC Cancer 2023 23:55
    Content type: Research Published on:

  44. Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are of potential magnetic resonance imaging (MRI) contrast agents for tumor diagnosis. However, ultrasmall particle size or negative surface charge...

    Authors: Changyuan Wang, Yang Wang, Wangchuan Xiao, Xiaohua Chen, Renfu Li, Zhiyong Shen and Fengchun Lu
    Citation: BMC Cancer 2023 23:54
    Content type: Research Published on:

  45. The role of preoperative serum tumor markers in HAS patients was vague, we designed the study to explore the effect of preoperative serum tumor markers on predicting the prognosis of HAS patients.

    Authors: Xuesong Yang, Anqiang Wang, Jialin Li, Kai Zhou, Ke Ji, Xin Ji, Ji Zhang, Xiaojiang Wu and Zhaode Bu
    Citation: BMC Cancer 2023 23:53
    Content type: Research Published on:

  46. TGF-β-induced factor homeobox 2 (TGIF2) is a transcription regulator that is phosphorylated by EGFR/ERK signaling. However, the functions of phosphorylated (p)-TGIF2 in cancer are largely unknown. Here, we inv...

    Authors: Renle Du, Chen Wang, Jingjing Liu, Keyan Wang, Liping Dai and Wenzhi Shen
    Citation: BMC Cancer 2023 23:52
    Content type: Research Published on:

  47. Currently, the standard treatment for locally advanced cervical cancer is concurrent chemoradiation (CCRT). Forty percent of patients present with disease recurrence. This study aims to investigate the feasibi...

    Authors: Jing Li, Ya Li, Huafeng Wang, Lifei Shen, Qun Wang, Siqi Shao, Yuhong Shen, Haoping Xu, Hua Liu, Rong Cai and Weiwei Feng
    Citation: BMC Cancer 2023 23:51
    Content type: Research Published on:

  48. To investigate the predictive value of metabolic syndrome (MetS) and its components in biochemical recurrence (BCR) and adverse pathological features of patients with prostate cancer (PCa) after radical prosta...

    Authors: Zenan Liu, Xuehua Zhu, Jide He and Jian Lu
    Citation: BMC Cancer 2023 23:50
    Content type: Research Published on:

  49. With the advent of intensive combination regimens, an increasing number of patients with unresectable pancreatic cancer (UPC) have regained the opportunity for surgery. We investigated the clinical benefits an...

    Authors: Xiang Li, Xinyuan Liu, Na Lu, Yiwen Chen, Xiaochen Zhang, Chengxiang Guo, Wenbo Xiao, Xing Xue, Ke Sun, Meng Wang, Shunliang Gao, Yan Shen, Min Zhang, Jian Wu, Risheng Que, Jun Yu…
    Citation: BMC Cancer 2023 23:49
    Content type: Research Published on:

  50. Primary myelofibrosis [PMF] is a myeloproliferative neoplasm associated with reduced overall survival (OS). Management strategies for PMF have evolved over the last two decades, including approval of ruxolitin...

    Authors: Tsewang Tashi, Jingbo Yu, Shivani Pandya, Christopher Dieyi, Robyn Scherber and Shreekant Parasuraman
    Citation: BMC Cancer 2023 23:48
    Content type: Research Published on:

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