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  1. B7 molecules play significant roles in regulating tumor immunity, but their expression patterns and immuno-biological correlations in pancreatic cancer (PaCa) have not been fully discussed.

    Authors: Jiayue Yang, Zhen Tian, Han Gao, Fan Xiong, Cuiping Cao, Jiaojiao Yu, Wei Shi, Qiang Zhan and Cheng Yang
    Citation: BMC Cancer 2022 22:584
  2. This study aimed to propose a new user-friendly, cost effective and robust risk model to facilitate risk stratification for diffuse large B-cell lymphoma (DLBCL) treated with frontline R-CHOP regimens.

    Authors: Haizhu Chen, Qiaofeng Zhong, Yu Zhou, Yan Qin, Jianliang Yang, Peng Liu, Xiaohui He, Shengyu Zhou, Changgong Zhang, Lin Gui, Sheng Yang, Liqiang Zhou and Yuankai Shi
    Citation: BMC Cancer 2022 22:583
  3. At present, “Belt and Road” (“B&R”) member states (accounting for about 61.78% of the world’s population) face different types of cancer threats to varying degrees. We analyzed the incidence and mortality and ...

    Authors: Baohua Wang, Fengdie He, Yanan Hu, Qiutong Wang, Dan Wang, Yuting Sha and Jing Wu
    Citation: BMC Cancer 2022 22:582
  4. Long non-coding RNA P73 antisense RNA 1 T (non-protein coding), also known as Lnc RNA TP73-AS1, is dysregulated in various tumors but the correlation between its expression and clinicopathological parameters a...

    Authors: Caizhi Chen, Jingjing Wang, Yeqian Feng, Ye Liang, Yan Huang and Wen Zou
    Citation: BMC Cancer 2022 22:581
  5. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) provide a better prognosis in EGFR-mutant non-small cell lung cancer (NSCLC). Nevertheless, the outcome of leptomeningeal metastasis (LM) re...

    Authors: Hainan Yang, Lei Wen, Yingying Pan, Changguo Shan, Weiping Hong, Hui Wang, Cheng Zhou, Linbo Cai and Caicun Zhou
    Citation: BMC Cancer 2022 22:580
  6. The ideal extent of lymphadenectomy (LAD) in esophageal oncological surgery is debated. There is no evidence for improved survival after standardized paratracheal lymph node resection performing oncological es...

    Authors: C. Mann, F. Berlth, E. Hadzijusufovic, E. Tagkalos, E. Uzun, C. Codony, H. Lang and P. P. Grimminger
    Citation: BMC Cancer 2022 22:579
  7. High-mobility group box 1 (HMGB1) is increased in breast cancer cells as the result of exposure to the secreted substances from cancer-associated fibroblasts and plays a crucial role in cancer progression and ...

    Authors: Kamolporn Amornsupak, Suyanee Thongchot, Chanida Thinyakul, Carol Box, Somaieh Hedayat, Peti Thuwajit, Suzanne A. Eccles and Chanitra Thuwajit
    Citation: BMC Cancer 2022 22:578
  8. Advanced non-squamous non-small cell lung cancer (NS-NSCLC) patients without driver gene mutations are usually treated with immune checkpoint inhibitors (ICIs) plus pemetrexed as maintenance therapy after firs...

    Authors: Xiaodong Gu, Zhiyong Shi, Lan Shao, Yuxin Zhang, Yiping Zhang, Zhengbo Song, Wenxian Wang and Guangyuan Lou
    Citation: BMC Cancer 2022 22:576
  9. Some cancers such as sarcomas (bone and soft tissue sarcomas) and adenoid cystic carcinomas are considered as radioresistant to low linear energy transfer radiation (including photons and protons) and may ther...

    Authors: Jacques Balosso, Olivia Febvey-Combes, Annie Iung, Hélène Lozano, Abdoulkader Soumai Alloh, Catherine Cornu, Magali Hervé, Zohra Akkal, Michel Lièvre, Valérie Plattner, Francesca Valvo, Cristina Bono, Maria Rosaria Fiore, Viviana Vitolo, Barbara Vischioni, Stéphanie Patin…
    Citation: BMC Cancer 2022 22:575
  10. Non-specific symptoms are  common and often sign of a non-serious disease. Because of this, patients with non-specific symptoms of cancer (NSSC) present a challenge for general practitioners (GP). Studies desc...

    Authors: Ellen Jensen, Jette Kolding Kristensen, Rikke Tveden Bjerglund, Søren Paaske Johnsen and Janus Laust Thomsen
    Citation: BMC Cancer 2022 22:574
  11. Extracellular vesicle (EV) biomarkers have promising diagnosis and screening capacity for several cancers, but the diagnostic value for pancreatic cancer (PC) is controversial. The aim of our study was to revi...

    Authors: Erna Jia, Na Ren, Xianquan Shi, Rongkui Zhang, Haixin Yu, Fan Yu, Shaoyou Qin and Jinru Xue
    Citation: BMC Cancer 2022 22:573
  12. Post-translational modification plays an important role in the occurrence and development of various tumors. However, few researches were focusing on the SUMOylation regulatory genes as tumor biomarkers to pre...

    Authors: Hongxu Sheng, Zhexue Hao, Linhai Zhu, Yuan Zeng and Jianxing He
    Citation: BMC Cancer 2022 22:572
  13. The addition of anti-angiogenesis drugs to epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) or chemotherapy in patients with EGFR-mutant non–small cell lung cancer (NSCLC) can improve di...

    Authors: Chieh-Lung Chen, Sing-Ting Wang, Wei-Chih Liao, Chia-Hung Chen, Chih-Yen Tu, Hung-Jen Chen, Te-Chun Hsia and Wen-Chien Cheng
    Citation: BMC Cancer 2022 22:571
  14. To develop and validate a nebulizer device for anti-cancer research on pressurized intraperitoneal aerosol supply in a preclinical peritoneal metastases (PM) rat model.

    Authors: Jonathan R. Buggisch, Daniel Göhler, Julien Sobilo, Stéphanie Lerondel, Günther A. Rezniczek, Michael Stintz, Andreas Rudolph, Nicolas Tabchouri, Sébastien Roger, Mehdi Ouaissi and Urs Giger-Pabst
    Citation: BMC Cancer 2022 22:570
  15. This report summarizes three phase I studies evaluating volasertib, a polo-like kinase inhibitor, plus azacitidine in adults with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myel...

    Authors: Uwe Platzbecker, Joerg Chromik, Jan Krönke, Hiroshi Handa, Stephen Strickland, Yasushi Miyazaki, Martin Wermke, Wataru Sakamoto, Yoshifumi Tachibana, Tillmann Taube and Ulrich Germing
    Citation: BMC Cancer 2022 22:569
  16. Cadherin-23 (CDH23) plays an important role in intercellular adhesion and is involved in the progression of several types of cancer. However, the biological functions and effect of CDH23 expression on the prog...

    Authors: Jiao Yang, Fei Lu, Guangxin Ma, Yihua Pang, Yanan Zhao, Tao Sun, Daoxin Ma, Jingjing Ye and Chunyan Ji
    Citation: BMC Cancer 2022 22:568
  17. The uncontrolled proliferation of cancer cells determines hypoxic conditions within the neoplastic mass with consequent activation of specific molecular pathways that allow cells to survive despite oxygen depr...

    Authors: Chiara Zichittella, Maria Magdalena Barreca, Aurora Cordaro, Chiara Corrado, Riccardo Alessandro and Alice Conigliaro
    Citation: BMC Cancer 2022 22:567
  18. The role of Berberine (BBR) in colorectal cancer (CRC) and gut microbiota has begun to appreciate. However, there was no direct evidence confirm that the gut microbiota regulated by BBR could inhibit CRC. This...

    Authors: Haitao Chen, Chenxiao Ye, Biyu Cai, Fan Zhang, Xuanying Wang, Jin Zhang, Zewei Zhang, Yong Guo and Qinghua Yao
    Citation: BMC Cancer 2022 22:566
  19. Anti-programmed cell death receptor-1 (PD-1) monotherapy is the standard treatment for metastatic melanoma in current. Camrelizumab is a humanized IgG4 anti-PD-1 monoclonal antibody whose safety and efficacy h...

    Authors: Li Zhou, Xiaowen Wu, Zhihong Chi, Lu Si, Xinan Sheng, Yan Kong, Lili Mao, Bin Lian, Bixia Tang, Xieqiao Yan, Xuan Wang, Xue Bai, Siming Li, Xiaoting Wei, Juan Li, Qing Yang…
    Citation: BMC Cancer 2022 22:565
  20. Ribosomal protein S6 (S6), a downstream effect media of the AKT/mTOR pathway, not only is a part of 40S small subunit of eukaryotic ribosome, but also involves in protein synthesis and cell proliferation durin...

    Authors: Yaoxiang Tang, Jiadi Luo, Ying Zhou, Hongjing Zang, Yang Yang, Sile Liu, Hongmei Zheng, Jian Ma, Songqing Fan and Qiuyuan Wen
    Citation: BMC Cancer 2022 22:564
  21. Metastatic pancreatic cancer (mPC) and its treatments significantly impact health-related quality of life (HRQoL). POLO, a randomized, double-blind, placebo-controlled phase 3 trial evaluated the efficacy of o...

    Authors: Suvina Amin, Seongjung Joo, Sandra Nolte, Hyun Kyoo Yoo, Nikunj Patel, Hilary F. Byrnes, Sara Costa-Cabral and Colin D. Johnson
    Citation: BMC Cancer 2022 22:563
  22. Studies have shown that DAB2IP inhibits cancer progression, while HSP90AA1 promotes cancer progression. However, the specific regulatory mechanism of DAB2IP and HSP90AA1 in colorectal cancer (CRC) is not clear...

    Authors: Mengna Zhang, Yanan Peng, Zhenwei Yang, Hailin Zhang, Cong Xu, Lan Liu, Qiu Zhao, Jixiong Wu, Hongling Wang and Jing Liu
    Citation: BMC Cancer 2022 22:561
  23. Given the psychosocial burdens patients in advanced stages of cancer face, innovative care concepts are needed. At the same time, such vulnerable patient groups are difficult to reach for participation in inte...

    Authors: Johann Frick, Pimrapat Gebert, Ulrike Grittner, Anne Letsch, Daniel Schindel and Liane Schenk
    Citation: BMC Cancer 2022 22:560
  24. Laminins are high-molecular weight (400 ~ 900 kDa) proteins in extracellular matrix, which serve as major component of the basal lamina, and play a crucial role in promoting tumor cell migration. This study ai...

    Authors: Nan Hao, Daming Yang, Tianpei Liu, Shucheng Liu, Xinsheng Lu and Libo Chen
    Citation: BMC Cancer 2022 22:558
  25. Chemokines are highly expressed in tumor microenvironment and play a critical role in all aspects of tumorigenesis, including the recruitment of tumor-promoting immune cells, activation of cancer-associated fi...

    Authors: Sarah Johnson, Yaroslava Karpova, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov and Alexei V. Tulin
    Citation: BMC Cancer 2022 22:557
  26. The bifunctional methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2) has been reported to play an oncogenic role in various types of cancers. However, the...

    Authors: Lin Zhu, Xianhui Liu, Weiyu Zhang, Hao Hu, Qi Wang and Kexin Xu
    Citation: BMC Cancer 2022 22:556
  27. It is known that geographic location plays a role in developing lung cancer. The objectives of this study were to examine spatio-temporal patterns of lung cancer incidence in Pennsylvania, to identify geograph...

    Authors: Nuria Camiña, Tara L. McWilliams, Thomas P. McKeon, Trevor M. Penning and Wei-Ting Hwang
    Citation: BMC Cancer 2022 22:555
  28. While prostate cancer (PCa) cells most often metastasize to bone in men, species-specific differences between human and mouse bone marrow mean that this pattern is not faithfully replicated in mice. Herein we ...

    Authors: Bianca Nowlan, Elizabeth D. Williams and Michael Robert Doran
    Citation: BMC Cancer 2022 22:554
  29. Breast cancer survivors have a unique risk for negative health outcomes. Engaging in routine physical activity (PA) can reduce these risks. However, PA levels are low among this population. Narrative visualiza...

    Authors: Jason R. Bentley, Xiaoying Yu, Amol M. Karmarkar, Brian Downer, John Prochaska and Elizabeth J. Lyons
    Citation: BMC Cancer 2022 22:553
  30. Immune-mediated pneumonitis has a high mortality rate; however, information regarding the related risk factors remains limited. This study aimed to analyze risk factors for pneumonitis, including smoking and l...

    Authors: Yasuki Uchida, Daisuke Kinose, Yukihiro Nagatani, Sachiko Tanaka-Mizuno, Hiroaki Nakagawa, Kentaro Fukunaga, Masafumi Yamaguchi and Yasutaka Nakano
    Citation: BMC Cancer 2022 22:551
  31. Homologous recombination deficiency (HRD) is a molecular biomarker for administrating PARP inhibitor (PARPi) or platinum-based (Pt) chemotherapy. The most well-studied mechanism of causing HRD is pathogenic BRCA1...

    Authors: Hao Wen, Zheng Feng, Yutong Ma, Rui Liu, Qiuxiang Ou, Qinhao Guo, Yi Shen, Xue Wu, Yang Shao, Hua Bao and Xiaohua Wu
    Citation: BMC Cancer 2022 22:550
  32. This study was conducted to evaluate the prognostic significance of different molecular typing methods and immune status based on RNA sequencing (RNA-seq) in hormone receptor (HR)-positive and human epidermal ...

    Authors: Xinyu Ren, Yu Song, Yanna zhang, Huanwen Wu, Longyun Chen, Junyi Pang, Liangrui Zhou, Songjie Shen and Zhiyong Liang
    Citation: BMC Cancer 2022 22:548
  33. During the cancer treatment path, cancer patients use numerous drugs, including anticancer, supportive, and other prescribed medications, along with herbs and certain products. This puts them at risk of signif...

    Authors: Amer A. Koni, Maisa A. Nazzal, Bushra A. Suwan, Samah S. Sobuh, Najiya T. Abuhazeem, Asil N. Salman, Husam T. Salameh, Riad Amer and Sa’ed H. Zyoud
    Citation: BMC Cancer 2022 22:547
  34. Body mass index (BMI) and cardiometabolic comorbidities such as cardiovascular disease and type 2 diabetes have been studied as negative prognostic factors in cancer survival, but possible dependencies in the ...

    Authors: Mirjam Kohls, Heinz Freisling, Hadrien Charvat, Isabelle Soerjomataram, Vivian Viallon, Veronica Davila-Batista, Rudolf Kaaks, Renée Turzanski-Fortner, Krasimira Aleksandrova, Matthias B. Schulze, Christina C. Dahm, Helene Tilma Vistisen, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Catalina Bonet, Maria-Jose Sánchez…
    Citation: BMC Cancer 2022 22:546
  35. Laryngeal squamous cell carcinoma (LSCC) is the most common squamous cell carcinoma. Though significant effort has been focused on molecular pathogenesis, development, and recurrence of LSCC, little is known ...

    Authors: Lvsheng Qian, Tingting Ni, Bing Fei, Hui Sun and Haosheng Ni
    Citation: BMC Cancer 2022 22:545
  36. The interaction between tumor microenvironment (TME) and tumors offers various targets in mounting anti-tumor immunotherapies. However, the prognostic biomarkers in endometrial carcinoma (EC) are still limited...

    Authors: Heng Ma, Peng-hui Feng, Shuang-ni Yu, Zhao-hui Lu, Qi Yu and Jie Chen
    Citation: BMC Cancer 2022 22:543
  37. To investigate pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) safety and efficacy in preventing hematological toxicity during concurrent chemoradiotherapy (CCRT) for small-cell...

    Authors: Cunliang Wang, Shouhui Zhu, Chuanwang Miao, Yu Wang, Jiazhen Chen, Shuanghu Yuan and Xudong Hu
    Citation: BMC Cancer 2022 22:542
  38. Pleural invasion (PL) has been regarded as an unfavorable prognostic factor for non-small cell lung cancer (NSCLC). But there was no agreement on the optimal surgical extent in NSCLC patients with PL. We aimed...

    Authors: Xue Song, Yangyang Xie, Yurou Zhu and Yafang Lou
    Citation: BMC Cancer 2022 22:541
  39. The standard of care treatment for soft tissue sarcoma of the extremities is a wide resection in combination with pre- or postoperative radiotherapy with high local control rates, sparing patients the necessit...

    Authors: D. Brügemann, B. Lehner, M. Kieser, J. Krisam, A. Hommertgen, C. Jaekel, S. B. Harrabi, K. Herfarth, G. Mechtesheimer, O. Sedlaczek, G. Egerer, A. Geisbüsch, M. Uhl, J. Debus and K. Seidensaal
    Citation: BMC Cancer 2022 22:538
  40. Perioperative chemotherapy and surgery are a standard of care for patients with resectable gastric or gastroesophageal junction (GEJ) adenocarcinoma. However, the prognosis remains poor for this population. Th...

    Authors: Mélanie Dos Santos, Justine Lequesne, Alexandra Leconte, Stéphane Corbinais, Aurélie Parzy, Jean-Marc Guilloit, Sharmini Varatharajah, Pierre-Emmanuel Brachet, Marine Dorbeau, Dominique Vaur, Louis-Bastien Weiswald, Laurent Poulain, Corentin Le Gallic, Marie Castera-Tellier, Marie-Pierre Galais and Bénédicte Clarisse
    Citation: BMC Cancer 2022 22:537
  41. As opposed to observation of the neck, elective neck dissection has a survival benefit for cN0 oropharyngeal squamous cell carcinoma (OPSCC). However, there are limited date on level IV neck dissection in huma...

    Authors: Zirong Huo, Shuiting Fu, Chunyue Ma and Surui Sheng
    Citation: BMC Cancer 2022 22:535
  42. Several studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined effect of cardiovascular risk factors on the risk of breast cancer is stil...

    Authors: Xiaoqi Zeng, Shanshan Jiang, Simin Ruan, Lijun Zhu, Huining Lian, Minfeng Liu, Zhaoze Guo, Jingyun Guo, Changsheng Ye, Yunjiu Cheng and Jianyu Dong
    Citation: BMC Cancer 2022 22:534
  43. Access to cancer care is a problem that continues to plague refugees displaced from their home countries. The turbulent political crisis in Syria, which has led to millions of refugees seeking asylum in Turkey...

    Authors: Mutlay Sayan, Mehmet Fuat Eren, Sarah Sabrine Kilic, Ayse Kotek, Sedenay Oskeroglu Kaplan, Ozge Duran, Funda Cukurcayır, Ibrahim Babalıoglu, Ozlem Derinalp Or, Gul Aysen Ozturk, Celalettin Eroglu, Fatma Teke, Neslihan Kurtul, Tugce Kutuk, Beyhan Ceylaner Bicakci, Sukran Senyurek…
    Citation: BMC Cancer 2022 22:532
  44. Racial and ethnic disparities in outcomes for Black and Hispanic children with acute leukemia have been well documented, however little is known about the determinants of diagnostic delays in pediatric leukemi...

    Authors: Lucky Ding, Julia E. Szymczak, Erica Evans, Emma Canepa, Ashley E. Martin, Farah Contractor, Richard Aplenc, Galen Joseph and Lena E. Winestone
    Citation: BMC Cancer 2022 22:531

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