Articles

CANT1 serves as a potential prognostic factor for lung adenocarcinoma and promotes cell proliferation and invasion in vitro

Calcium-activated nucleotidase 1 (CANT1), functions as a calcium-dependent nucleotidase with a preference for UDP. However, the potential clinical value of CANT1 in lung adenocarcinoma (LA) has not been fully ...

Authors: Qiwei Yao, Yilin Yu, Zhiping Wang, Mengyan Zhang, Jiayu Ma, Yahua Wu, Qunhao Zheng and Jiancheng Li

The expression and survival significance of sodium glucose transporters in pancreatic cancer

Sodium glucose transporters (SGLTs) play vital roles in glucose uptake in many solid cancers, including pancreatic cancer (PC). However, their expression profile in pancreatic cancer and correlation with progn...

Authors: Jiali Du, Jichun Gu, Junyuan Deng, Lei Kong, Yujie Guo, Chen Jin, Yun Bao, Deliang Fu and Ji Li

Identification of a ZC3H12D-regulated competing endogenous RNA network for prognosis of lung adenocarcinoma at single-cell level

To identify hub genes from the competing endogenous RNA (ceRNA) network of lung adenocarcinoma (LUAD) and to explore their potential functions on prognosis of patients from a single-cell perspective.

Authors: Wenhan Chen, Zhifeng Guo, Jingyang Wu, Guofu Lin, Shaohua Chen, Qinhui Lin, Jiansheng Yang, Yuan Xu and Yiming Zeng

Online calculator to predict early mortality in patient with surgically treated recurrent lower-grade glioma

The aim of this study was to investigate the epidemiological characteristics and associated risk factors of recurrent lower-grade glioma [LGG] (WHO grades II and III) according to the 2016 updated WHO classifi...

Authors: Ruolun Wei, Chao Zhao, Jianguo Li, Fengdong Yang, Yake Xue and Xinting Wei

Predictive value of preoperative platelet-to-albumin ratio and apolipoprotein B-to-apolipoprotein A1 ratio for osteosarcoma in children and adolescents: a retrospective study of 118 cases

This retrospective study investigated biomarkers that can reflect coagulation, inflammation, and lipid abnormalities: platelet-to-albumin ratio (PAR), platelet-to lymphocyte ratio (PLR), low-density lipoprotei...

Authors: Cong Ma, Ruizhen Li, Ronghui Yu, Jingjing Guo, Jianyun Xu, Xuhui Yuan and Jianfeng Guo

Correction to: Mapping the EORTC QLQ-C30 to EQ-5D-3L in patients with breast cancer

Authors: Laura A. Gray, Monica Hernandez Alava and Allan J. Wailoo

Improving power in PSA response analyses of metastatic castration-resistant prostate cancer trials

To determine how much an augmented analysis approach could improve the efficiency of prostate-specific antigen (PSA) response analyses in clinical practice. PSA response rates are commonly used outcome measure...

Authors: Michael J. Grayling, Martina McMenamin, Robert Chandler, Rakesh Heer and James M. S. Wason

High complement protein C1q levels in pulmonary fibrosis and non-small cell lung cancer associated with poor prognosis

Idiopathic pulmonary fibrosis (IPF) is the most common type of interstitial pneumonia. Lung cancer, mainly non-small cell lung cancer (NSCLC), is a complication of idiopathic pulmonary fibrosis. IPF is also an...

Authors: Wenxin Kou, Bo Li, Yeifei Shi, Yifan Zhao, Qing Yu, Jianhui Zhuang, Yawei Xu and Wenhui Peng

The Patient Navigator: Can a systematically developed online health information tool improve patient participation and outcomes related to the consultation in older patients newly diagnosed with colorectal cancer?

Older cancer patients may search for health information online to prepare for their consultations. However, seeking information online can have negative effects, for instance increased anxiety due to finding i...

Authors: Melanie de Looper, Ellen M. A. Smets, Barbara C. Schouten, Sifra Bolle, Eric H. J. Belgers, Eric H. Eddes, Jeroen W. A. Leijtens and Julia C. M. van Weert

The role of SPI1-TYROBP-FCER1G network in oncogenesis and prognosis of osteosarcoma, and its association with immune infiltration

Osteosarcoma is an aggressive malignant bone sarcoma worldwide. A causal gene network with specific functions underlying both the development and progression of OS was still unclear. Here we firstly identified...

Authors: Jiahua Li, Hui Shi, Zhanyuan Yuan, Zhiheng Wu, Haohao Li, Yuelong Liu, Ming Lu and Ming Lu

Identification of TIMELESS and RORA as key clock molecules of non-small cell lung cancer and the comprehensive analysis

The incidence rate of non-small cell lung cancer (NSCLC) has been increasing worldwide, and the correlation of circadian rhythm disruption with a raised risk of cancer and worse prognosis has been shown by acc...

Authors: Haocheng Xian, Yuan Li, Boliang Zou, Yajuan Chen, Houqing Yin, Xuejun Li and Yan Pan

An observational study of workflows to support fecal testing for colorectal cancer screening in primary care practices serving Medicaid enrollees

Screening supports early detection and treatment of colorectal cancer (CRC). Provision of fecal immunochemical tests/fecal occult blood tests (FIT/FOBT) in primary care can increase CRC screening, particularly...

Authors: Cynthia M. Mojica, Rose Gunn, Robyn Pham, Edward J. Miech, Ann Romer, Stephanie Renfro, Khaya D. Clark and Melinda M. Davis

The mixed blessing of AMPK signaling in Cancer treatments

Nutrient acquisition and metabolism pathways are altered in cancer cells to meet bioenergetic and biosynthetic demands. A major regulator of cellular metabolism and energy homeostasis, in normal and cancer cel...

Authors: Mehrshad Sadria, Deokhwa Seo and Anita T. Layton

The influence of docetaxel schedule on treatment tolerability and efficacy in patients with metastatic breast cancer: a systematic review and meta-analysis of randomized controlled trials

Administration of single-agent docetaxel in a weekly schedule may offer similar efficacy, with a more favorable toxicity profile, compared to a three-weekly schedule in patients with metastatic breast cancer.

Authors: Maarten van Eijk, Marit A. C. Vermunt, Erik van Werkhoven, Erica A. Wilthagen, Alwin D. R. Huitema and Jos H. Beijnen

Effect of tumour size ratio on liver recurrence-free survival of patients undergoing hepatic resection for colorectal liver metastases

The study aimed to assess the impact of size differences of multiple liver metastases on liver recurrence-free survival (RFS) in patients undergoing hepatic resection for colorectal liver metastases (CRLMs).

Authors: Yana Zhai, Weijun Bai, Jin Zhou, Qian Dong and Jingdong Zhang

Lympho-vascular invasion impacts the prognosis in breast-conserving surgery: a systematic review and meta-analysis

It is estimated that breast cancer (BC) incidence, especially that of early-stage breast cancer cases continues to rise due to increased universal screening. Breast-conserving surgery (BCS) is the main interve...

Authors: Yi-Ming Zhong, Fei Tong and Jun Shen

Effect of prior antibiotic or chemotherapy treatment on immunotherapy response in non-small cell lung cancer

Treatment outcomes of advanced non-small cell lung cancer (NSCLC) have substantially improved with immune checkpoint inhibitors (ICI), although only approximately 19% of patients respond to immunotherapy alone...

Authors: Andrew F. Nyein, Shahla Bari, Stephanie Hogue, Yayi Zhao, Bradley Maller, Sybil Sha, Maria F. Gomez, Dana E. Rollison and Lary A. Robinson

Sequential azacitidine and carboplatin induces immune activation in platinum-resistant high-grade serous ovarian cancer cell lines and primes for checkpoint inhibitor immunotherapy

Platinum chemoresistance results in high-grade serous ovarian cancer (HGSOC) disease recurrence. Recent treatment advances using checkpoint inhibitor immunotherapy has not benefited platinum-resistant HGSOC. I...

Authors: Michelle W. Wong-Brown, Andre van der Westhuizen and Nikola A. Bowden

The MITRE trial protocol: a study to evaluate the microbiome as a biomarker of efficacy and toxicity in cancer patients receiving immune checkpoint inhibitor therapy

The gut microbiome is implicated as a marker of response to  immune checkpoint inhibitors (ICI) based on preclinical mouse models and preliminary observations in limited patient series. Furthermore, early stud...

Authors: Nicola A. Thompson, Grant D. Stewart, Sarah J. Welsh, Gary J. Doherty, Matthew J. Robinson, B. Anne Neville, Kevin Vervier, Simon R. Harris, David J. Adams, Katy Dalchau, David Bruce, Nikolaos Demiris, Trevor D. Lawley and Pippa G. Corrie

Adverse effects in hematologic malignancies treated with chimeric antigen receptor (CAR) T cell therapy: a systematic review and Meta-analysis

Recently, chimeric antigen receptor-modified (CAR) T cell therapy for hematological malignancies has shown clinical efficacy. Hundreds of clinical trials have been registered and lots of studies have shown hem...

Authors: Wenjing Luo, Chenggong Li, Yinqiang Zhang, Mengyi Du, Haiming Kou, Cong Lu, Heng Mei and Yu Hu

Correction to: Guy’s and St Thomas NHS Foundation active surveillance prostate cancer cohort: a characterisation of a prostate cancer active surveillance database

An amendment to this paper has been published and can be accessed via the original article.

Authors: Salonee Shah, Kerri Beckmann, Mieke Van Hemelrijck, Ben Challacombe, Rick Popert, Prokar Dasgupta, Jonah Rusere, Grace Zisengwe, Oussama Elhage and Aida Santaolalla

Dose-escalation by hypofractionated simultaneous integrated boost IMRT in unresectable stage III non-small-cell lung cancer

To explore the maximum tolerated dose (MTD) and evaluate the safety of dose escalation using hypofractionated simultaneous integrated boost intensity-modulated radiotherapy (SIB-IMRT) concurrent with chemother...

Authors: Qin Zhang, Xu-Wei Cai, Wen Feng, Wen Yu and Xiao-Long Fu

Dietary patterns and severity of symptom with the risk of esophageal squamous cell carcinoma and its histological precursor lesions in China: a multicenter cross-sectional latent class analysis

Dietary patterns and symptoms research among Chinese with esophageal squamous cell carcinoma (ESCC) and its precursor lesions is limited, especially as it relates to multiple food consumption and multiple co-o...

Authors: Zhaoping Zang, Yong Liu, Jialin Wang, Yuqin Liu, Shaokai Zhang, Yongzhen Zhang, Liwei Zhang, Deli Zhao, Fugang Liu, Lina Chao, Xinzheng Wang, Chunli Zhang, Guohui Song, Zhiyi Zhang, Youpeng Li, Zheng Yan…

Standardization of evaluation method and prognostic significance of histological response to preoperative chemotherapy in high-grade non-round cell soft tissue sarcomas

Preoperative chemotherapy is widely applied to high-grade localized soft tissue sarcomas (STSs); however, the prognostic significance of histological response to chemotherapy remains controversial. This study ...

Authors: Yoshinao Oda, Kazuhiro Tanaka, Takanori Hirose, Tadashi Hasegawa, Nobuyuki Hiruta, Masanori Hisaoka, Masato Yoshimoto, Hiroshi Otsuka, Hirofumi Bekki, Takeaki Ishii, Makoto Endo, Toshiyuki Kunisada, Toru Hiruma, Hiroyuki Tsuchiya, Hirohisa Katagiri, Yoshihiro Matsumoto…

Serum cholinesterase may independently predict prognosis in non-small-cell lung cancer

Serum cholinesterase (ChE) was found to be involved in cancer initiation and progression. However, the survival association between serum ChE and non-small cell lung cancer (NSCLC) has not been extensively dis...

Authors: Hailiang Ran, Jie Ma, Le Cai, Hai Zhou, Zhongqin Yuan, Ying Chen, Wei Chang, Yunchao Huang and Yuanyuan Xiao

Fibrinogen/albumin ratio as a promising predictor of platinum response and survival in ovarian clear cell carcinoma

This study aims to evaluate the role of the fibrinogen/albumin ratio (FAR) in predicting platinum resistance and survival outcomes of patients with ovarian clear cell carcinoma (OCCC).

Authors: Wei Chen, Boer Shan, Shuling Zhou, Huijuan Yang and Shuang Ye

Statin use is associated with the reduction in hepatocellular carcinoma recurrence after liver surgery

Hepatocellular carcinoma (HCC) is the sixth most common form of cancer worldwide. Although surgical treatments have an acceptable cure rate, tumor recurrence is still a challenging issue. In this meta-analysis...

Authors: Elias Khajeh, Arash Dooghaie Moghadam, Pegah Eslami, Sadeq Ali-Hasan-Al-Saegh, Ali Ramouz, Saeed Shafiei, Omid Ghamarnejad, Sepehr Abbasi Dezfouli, Christian Rupp, Christoph Springfeld, Carlos Carvalho, Pascal Probst, Seyed Mostafa Mousavizadeh and Arianeb Mehrabi

Effects of an oral mucosa protective formulation on chemotherapy- and/or radiotherapy-induced oral mucositis: a prospective study

Oral mucositis (OM) associated with cancer treatment not only impairs patients’ quality of life but also causes treatment delays or changes. This prospective exploratory study was conducted to evaluate the eff...

Authors: Takao Ueno, Wakako Yatsuoka, Hiroto Ishiki, Kanako Miyano and Yasuhito Uezono

Metabolic phenotypes and risk of colorectal cancer: a systematic review and meta-analysis of cohort studies

The association of obesity with colorectal cancer (CRC) may vary depending on metabolic status.

Authors: Golnoosh Goodarzi, Hadis Mozaffari, Tahereh Raeisi, Fatemeh Mehravar, Bahman Razi, Maryam Lafzi Ghazi, Nazila Garousi, Shahab Alizadeh and Parisa Janmohammadi

Extracellular vesicles mediated proinflammatory macrophage phenotype induced by radiotherapy in cervical cancer

Radiotherapy is a highly effective treatment for cervical cancer. Recent studies focused on the radiotherapy induced anti-tumor immunity. Whether tumor-derived extracellular vesicles (EVs) play roles in radiot...

Authors: Junli Ren, Lili Li, Baofeng Yu, Enwei Xu, Naiping Sun, Xiaoning Li, Zihan Xing, Xiaodong Han, Yaqin Cui, Xiaoyan Wang, Xiaoxue Zhang and Guoliang Wang

Comparative analysis of the value of amide proton transfer-weighted imaging and diffusion kurtosis imaging in evaluating the histological grade of cervical squamous carcinoma

Uterine cervical cancer (UCC) was the fourth leading cause of cancer death among women worldwide. The conventional MRI hardly revealing the microstructure information. This study aimed to compare the value of ...

Authors: Mengyan Hou, Kai Song, Jipeng Ren, Kaiyu Wang, Jinxia Guo, Yongchao Niu, Zhenyu Li and Dongming Han

Deep learning identified glioblastoma subtypes based on internal genomic expression ranks

Glioblastoma (GBM) can be divided into subtypes according to their genomic features, including Proneural (PN), Neural (NE), Classical (CL) and Mesenchymal (ME). However, it is a difficult task to unify various...

Authors: Xing-gang Mao, Xiao-yan Xue, Ling Wang, Wei Lin and Xiang Zhang

Whole genome deep sequencing analysis of cell-free DNA in samples with low tumour content

Circulating cell-free DNA (cfDNA) in the plasma of cancer patients contains cell-free tumour DNA (ctDNA) derived from tumour cells and it has been widely recognized as a non-invasive source of tumour DNA for d...

Authors: Devika Ganesamoorthy, Alan James Robertson, Wenhan Chen, Michael B. Hall, Minh Duc Cao, Kaltin Ferguson, Sunil R. Lakhani, Katia Nones, Peter T. Simpson and Lachlan J. M. Coin

Identification of an ACK1/TNK2-based prognostic signature for colon cancer to predict survival and inflammatory landscapes

Activated Cdc42-associated kinase 1 (ACK1), a kind of tyrosine kinase, is considered to be an oncogene in many cancers, and it is likely to become a potential target for cancer treatment. We found that the exp...

Authors: Defeng Kong, Guoliang Li, Zhenrong Yang, Shujun Cheng, Wen Zhang, Lin Feng and Kaitai Zhang

Overexpression of PFKFB3 promotes cell glycolysis and proliferation in renal cell carcinoma

Cancer cells prefer utilizing aerobic glycolysis in order to exacerbate tumor mass and maintain un-regulated proliferative rates. As a key glycolytic activator, phosphofructo-2-kinase/fructose-2,6-bisphosphata...

Authors: Jun Li, Shiqiang Zhang, Dingzhun Liao, Qian Zhang, Chujie Chen, Xiangwei Yang, Donggen Jiang and Jun Pang

Treatment outcomes of esophageal cancer in Eastern Africa: protocol of a multi-center, prospective, observational, open cohort study

Esophageal squamous cell carcinoma (ESCC) is a major cause of cancer morbidity and mortality in Eastern Africa. The majority of patients with ESCC in Eastern Africa present with advanced disease at the time of...

Authors: Geoffrey C. Buckle, Alita Mrema, Michael Mwachiro, Yona Ringo, Msiba Selekwa, Gift Mulima, Fatma F. Some, Blandina T. Mmbaga, Gita N. Mody, Li Zhang, Alan Paciorek, Larry Akoko, Paul Ayuo, Stephen Burgert, Elizabeth Bukusi, Anthony Charles…

Alpha-1 antitrypsin deficiency and risk of lung cancer in never-smokers: a multicentre case–control study

Lung cancer (LC) is the most commonly diagnosed cancer and the leading cause of cancer-related death in both sexes worldwide. Although the principal risk factor in the western world is tobacco smoking, genetic...

Authors: Ramón Antonio Tubío-Pérez, María Torres-Durán, María Esmeralda García-Rodríguez, Cristina Candal-Pedreira, Julia Rey-Brandariz, Mónica Pérez-Ríos, Juan Barros-Dios, Alberto Fernández-Villar and Alberto Ruano-Raviña

Modulation of chemoimmunotherapy efficacy in non-small cell lung cancer by sex and histology: a real-world, patient-level analysis

It has been postulated that patient’s sex impacts response to immunotherapy. Sex modulation of immunotherapy benefit, however, has not yet been explored using patient-level data, where potential confounders, a...

Authors: Stephanie Tuminello, Naomi Alpert, Rajwanth R. Veluswamy, Arvind Kumar, Jorge E. Gomez, Raja Flores and Emanuela Taioli

Radiosynthesis of a novel antisense imaging probe targeting LncRNA HOTAIR in malignant glioma

Long non-coding RNA (LncRNA) HOTAIR was amplified and overexpressed in many human carcinomas, which could serve as a useful target for cancer early detection and treatment. The ^99mTc radiolabeled antisense oligon...

Authors: Jiongyu Ren, Xiyuan Zhang, Jiang Cao, Jiali Tian, Jin Luo, Yaping Yu, Fengkui Wang and Qian Zhao

HoSAGE: sarcopenia in older patient with intermediate / high-risk prostate cancer, prevalence and incidence after androgen deprivation therapy: study protocol for a cohort trial

Sarcopenia is defined by a loss of muscle strength associated to a decrease in skeletal muscle mass. Ageing greatly contributes to sarcopenia as may many other factors such as cancer or androgen deprivation th...

Authors: Anne-Laure Couderc, Patrick Villani, Julie Berbis, Emilie Nouguerède, Dominique Rey, Dominique Rossi, Éric Lechevallier, Delphine Badinand, Cyrille Bastide, Gilles Karsenty, Romain Boissier, Kahena Amichi and Xavier Muracciole

High expression of S100A2 predicts poor prognosis in patients with endometrial carcinoma

S100A2, a member of the S100 protein family, is abnormally expressed and plays a vital role in multiple cancers. However, little is known about the clinical significance of S100A2 in endometrial carcinoma.

Authors: Qinzhen Zhang, Tianxiang Xia, Chenxiang Qi, Jun Du and Chunping Ye

The role of liver resection in metastatic nephroblastoma: a systematic review and Meta-regression analysis

The impact of hepatic resection for liver metastases (LM) on the survival of pediatric patients with Wilms’ tumor (WT) is unclear. So far, there is a lack of studies investigating the best suited treatment for...

Authors: Juri Fuchs, Anastasia Murtha-Lemekhova, Markus Kessler, Patrick Günther and Katrin Hoffmann

NSAID use and unnatural deaths after cancer diagnosis: a nationwide cohort study in Sweden

Cancer patients experience increased risk of death from accident and suicide. Cognitive impairment induced by cancer-related inflammation and stress-related psychiatric symptoms may be underlying mechanisms. W...

Authors: Qing Shen, Arvid Sjölander, Erica K. Sloan, Adam K. Walker, Katja Fall, Unnur Valdimarsdottir, Pär Sparén, Karin E. Smedby and Fang Fang

Two novel prognostic models for ovarian cancer respectively based on ferroptosis and necroptosis

Platinum-resistant cases account for 25% of ovarian cancer patients. Our aim was to construct two novel prognostic models based on gene expression data respectively from ferroptosis and necroptosis, for predic...

Authors: Yang Li, Xiaojin Gong, Tongxiu Hu and Yurong Chen

Microsatellite instability is biased in Amsterdam II-defined Lynch-related cancer cases with family history but is rare in other cancers: a summary of 1000 analyses

Microsatellite instability (MSI) is a key marker for predicting the response of immune checkpoint inhibitors (ICIs) and for screening Lynch syndrome (LS).

Authors: Hiroyuki Matsubayashi, Satomi Higashigawa, Yoshimi Kiyozumi, Takuma Oishi, Keiko Sasaki, Hirotoshi Ishiwatari, Kenichiro Imai, Kinichi Hotta, Yohei Yabuuchi, Kazuma Ishikawa, Tatsunori Satoh, Hiroyuki Ono, Akiko Todaka, Takeshi Kawakami, Hiromichi Shirasu, Hirofumi Yasui…

SMAD4–201 transcript as a putative biomarker in colorectal cancer

Transcripts with alternative 5′-untranslated regions (UTRs) result from the activity of alternative promoters and they can determine gene expression by influencing its stability and translational efficiency, t...

Authors: Tamara Babic, Sandra Dragicevic, Marko Miladinov, Zoran Krivokapic and Aleksandra Nikolic

Comparison of surgical outcomes and prognosis between wedge resection and simple Segmentectomy for GGO diameter between 2 cm and 3 cm in non-small cell lung cancer: a multicenter and propensity score matching analysis

As segmentectomy had become commonly used for Non-Small Cell Lung Cancer (NSCLC) treatment, which had the advantages of radical operation, however, it remains controversial owing to procedural complexity and r...

Authors: Yaodong Zhou, Tao Yu, Yixin Zhang, Liqiang Qian and Qing Xia

An estimate of rate of deviation from NCCN guideline recommendations for central nervous system imaging in trials forming basis for drug approval in first line advanced non-small cell lung cancer (NSCLC)

It is unknown whether and to what degree trials submitted to the US FDA to support drug approval adhere to NCCN guideline-recommended care in their baseline and surveillance CNS imaging protocols.

Authors: John Sharp and Vinay Prasad

Women’s health behaviour change after receiving breast cancer risk estimates with tailored screening and prevention recommendations

The Predicting Risk of Cancer at Screening (PROCAS) study provided women who were eligible for breast cancer screening in Greater Manchester (United Kingdom) with their 10-year risk of breast cancer, i.e., low...

Authors: Linda Rainey, Daniëlle van der Waal, Louise S. Donnelly, Jake Southworth, David P. French, D. Gareth Evans and Mireille J. M. Broeders

THUNDER 2: THeragnostic Utilities for Neoplastic DisEases of the Rectum by MRI guided radiotherapy

Neoadjuvant chemoradiation therapy (nCRT) is the standard treatment modality in locally advanced rectal cancer (LARC). Since response to radiotherapy (RT) is dose dependent in rectal cancer, dose escalation ma...

Authors: Giuditta Chiloiro, Davide Cusumano, Luca Boldrini, Angela Romano, Lorenzo Placidi, Matteo Nardini, Elisa Meldolesi, Brunella Barbaro, Claudio Coco, Antonio Crucitti, Roberto Persiani, Lucio Petruzziello, Riccardo Ricci, Lisa Salvatore, Luigi Sofo, Sergio Alfieri…