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  1. Preoperative chemoradiotherapy with capecitabine is considered as a standard of care for locally advanced rectal cancer. The “Tratamiento de Tumores Digestivos” group (TTD) previously reported in a randomized ...

    Authors: Ramón Salazar, Jaume Capdevila, Jose Luis Manzano, Carles Pericay, Mercedes Martínez-Villacampa, Carlos López, Ferrán Losa, María José Safont, Auxiliadora Gómez-España, Vicente Alonso-Orduña, Pilar Escudero, Javier Gallego, Beatriz García-Paredes, Amalia Palacios, Sebastiano Biondo, Cristina Grávalos…

    Citation: BMC Cancer 2020 20:1164

    Content type: Research article

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  2. Transforming growth factor-β (TGF-β) signaling is a double-edged sword in cancer development and progression. TGF-β signaling plays a tumor suppressive role during the early stages of tumor development but pro...

    Authors: Hwa-Kyung Son, Dokyeong Kim, Yongwoon Lim, Jin Kim and Iha Park

    Citation: BMC Cancer 2020 20:1163

    Content type: Research article

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  3. Aggressive systemic mastocytosis (ASM) is a rare malignant disease characterized by disordered mast cell accumulation in various organs. We here describe a female ASM patient with a previous history of ovarian...

    Authors: Makiko Tsutsumi, Hiroki Miura, Hidehito Inagaki, Yasuko Shinkai, Asuka Kato, Takema Kato, Susumu Hamada-Tsutsumi, Makito Tanaka, Kazuko Kudo, Tetsushi Yoshikawa and Hiroki Kurahashi

    Citation: BMC Cancer 2020 20:1162

    Content type: Research article

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  4. Surgical resection is the major way to cure pancreatic ductal adenocarcinoma (PDAC). However, this operation is complex, and the peri-operative risk is high, making patients more likely to be admitted to the i...

    Authors: Yijue Zhang, Sibo Zhu, Zhiqing Yuan, Qiwei Li, Ruifeng Ding, Xunxia Bao, Timing Zhen, Zhiliang Fu, Hailong Fu, Kaichen Xing, Hongbin Yuan and Tao Chen

    Citation: BMC Cancer 2020 20:1161

    Content type: Research article

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  5. Despite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involve...

    Authors: Xiao-Han Cui, Shu-Yi Hu, Chun-Fu Zhu and Xi-Hu Qin

    Citation: BMC Cancer 2020 20:1160

    Content type: Research article

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  6. Strong evidences support the critical role of Jumonji domain containing 6 (JMJD6) in progression of breast cancer. Here we explore potential partners that coregulate gene expression, to understand additional p...

    Authors: Antara Biswas, Geetashree Mukherjee, Paturu Kondaiah and Kartiki V. Desai

    Citation: BMC Cancer 2020 20:1159

    Content type: Research article

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  7. Human CD133+ hematopoietic progenitor cells (HPCs) are a specific subset of cells that can regulate tumor malignancy. However, the mechanism by which CD133+ HPCs affect the malignancy of human breast cancer ha...

    Authors: Zhe Zhang, Qinglian Zheng, Yonghui Liu, Lianqing Sun, Pingping Han, Rui Wang, Jiao Zhao, Shan Hu and Xinhan Zhao

    Citation: BMC Cancer 2020 20:1158

    Content type: Research article

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  8. Patients with relapsed or refractory peripheral T-cell lymphoma (R/R PTCL) treated with pralatrexate have previously shown superior overall survival (OS) compared to those who underwent conventional chemothera...

    Authors: Seonyoung Park, Ah-Young Kim, Hyeonseok Cho, Deborah Baik, Hankil Lee, Sunghwa Cho and Hye-Young Kang

    Citation: BMC Cancer 2020 20:1157

    Content type: Research article

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  9. To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), and to investigate the role of radiotherapy (RT) in patients with pT1–2N1M0 breast cancer.

    Authors: Guang-Yi Sun, Ge Wen, Yu-Jing Zhang, Yu Tang, Hao Jing, Jian-Yang Wang, Jiang-Hu Zhang, Yong Yang, Xu-Ran Zhao, Si-Ye Chen, Jing Jin, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Hua Ren, Yuan Tang…

    Citation: BMC Cancer 2020 20:1155

    Content type: Research article

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  10. We compared outcomes and toxicities between concurrent retrograde super-selective intra-arterial chemoradiotherapy (IACRT) and concurrent systemic chemoradiotherapy (SCRT) for gingival carcinoma (GC).

    Authors: Yuki Mukai, Yuichiro Hayashi, Izumi Koike, Toshiyuki Koizumi, Madoka Sugiura, Senri Oguri, Shoko Takano, Mitomu Kioi, Mizuki Sato, Kenji Mitsudo and Masaharu Hata

    Citation: BMC Cancer 2020 20:1154

    Content type: Research article

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  11. The aim of this study was to translate and linguistically validate the U.S. National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) into...

    Authors: Cheng KKF, S. A. Mitchell, N. Chan, E. Ang, W. Tam and R. Kanesvaran

    Citation: BMC Cancer 2020 20:1153

    Content type: Research article

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  12. Progressive lung cancer is associated with abnormal coagulation. Platelets play a vital part in evading immune surveillance and angiogenesis in the case of tumor metastasis. The study aimed to analyze the pred...

    Authors: Lu Xu, Fangzhou Xu, Haobo Kong, Meiling Zhao, Yuanzi Ye and Yanbei Zhang

    Citation: BMC Cancer 2020 20:1152

    Content type: Research article

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  13. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alexander Arnold, Moritz Tronser, Christine Sers, Aysel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Matthias Kloor and Hendrik Bläker

    Citation: BMC Cancer 2020 20:1151

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:1038

  14. Whether tumour-infiltrating lymphocytes (TILs) play different roles in different molecular subtypes of breast cancer remains unknown. Additionally, their prognostic and predictive value in different molecular ...

    Authors: Zhao-hua Gao, Cun-xin Li, Ming Liu and Jia-yuan Jiang

    Citation: BMC Cancer 2020 20:1150

    Content type: Research article

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  15. Metastatic colorectal cancer (mCRC) remains a lethal disease. Survival, however, is increasing due to a growing number of treatment options. Yet due to the number of prognostic factors and their interactions, ...

    Authors: Holger Rumpold, Dora Niedersüß-Beke, Cordula Heiler, David Falch, Helwig Valenting Wundsam, Sigrid Metz-Gercek, Gudrun Piringer and Josef Thaler

    Citation: BMC Cancer 2020 20:1149

    Content type: Research article

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  16. Population-based analysis for the short-term non-bladder cancer related mortality among patients with non-metastatic bladder cancer is currently lacking. The objective of the current study was to assess and qu...

    Authors: Menghe Zhai, Chenye Tang, Ming Li, Xin Chen, Yigang Jin, Xiangjun Ying, Zhiling Tang, Xiao Wang, Yuntao Wu, Chun Sun, Kean Chen and Xiao Guo

    Citation: BMC Cancer 2020 20:1148

    Content type: Research article

    Published on:

  17. When the resected specimen is sent for intraoperative margin assessment, all margins are grossly checked, and selected margins undergo a frozen section (FS) examination. Therefore, there is a possibility of sa...

    Authors: Hana’a Hezam Algadi, Amany Abd-Elhameed Abou-Bakr, Omer Mohammed Jamali and Louloua Mohamed Fathy

    Citation: BMC Cancer 2020 20:1147

    Content type: Research article

    Published on:

  18. The value of postmastectomy radiotherapy (PMRT) for pathological node-positive triple-negative breast cancers (TNBC) remains debatable. The aim of this population-based retrospective study was to evaluate the ...

    Authors: Lei Zhang, Ru Tang, Jia-Peng Deng, Wen-Wen Zhang, Huan-Xin Lin, San-Gang Wu and Zhen-Yu He

    Citation: BMC Cancer 2020 20:1146

    Content type: Database

    Published on:

  19. Breast cancer is the most common malignancy in women, and it is also the leading cause of death in female patients; the most common pathological type of BC is infiltrating duct carcinoma (IDC). Some nomograms ...

    Authors: Zhangheng Huang, Chuan Hu, Kewen Liu, Luolin Yuan, Yinglun Li, Chengliang Zhao and Chanchan Hu

    Citation: BMC Cancer 2020 20:1145

    Content type: Research article

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  20. In order to obtain a high dose conformal index of tumor and steep dose fall-off in healthy tissues for brain metastasis stereotactic radiosurgery (SRS), the aim of this study was to investigate SRS planning op...

    Authors: Xuyao Yu, Yuwen Wang, Zhiyong Yuan, Hui Yu, Yongchun Song, Lujun Zhao and Ping Wang

    Citation: BMC Cancer 2020 20:1144

    Content type: Research article

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  21. Interleukin-1 receptor antagonist (IL1RN) has been reported as a biomarker of many cancers. However, the biological function of IL1RN in papillary thyroid carcinoma (PTC) remains undetermined.

    Authors: Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Shijie Xin and Jian Zhang

    Citation: BMC Cancer 2020 20:1143

    Content type: Research article

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  22. Prehabilitation with regular exercise and nutritional care for patients undergoing surgeries for malignant disease was recently introduced to increase physiologic reserve prior to the procedure, accelerate rec...

    Authors: Erik Rupnik, Matevz Skerget, Matjaz Sever, Irena Preloznik Zupan, Maja Ogrinec, Barbara Ursic, Natasa Kos, Peter Cernelc and Samo Zver

    Citation: BMC Cancer 2020 20:1142

    Content type: Research article

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  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhenhua Yin, Dejun Wu, Jianping Shi, Xiyi Wei, Nuyun Jin, Xiaolan Lu and Xiaohan Ren

    Citation: BMC Cancer 2020 20:1141

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:1062

  24. Allogeneic stem cell transplantation from haploidentical donor using an unmanipulated graft and post-transplantation cyclophosphamide (PT-Cy) is growing. Haploidentical transplantation with PT-Cy showed a majo...

    Authors: Luca Castagna, Alessandro Busca, Stefania Bramanti, Maria Raiola Anna, Michele Malagola, Fabio Ciceri, William Arcese, Daniele Vallisa, Francesca Patriarca, Giorgina Specchia, Roberto Raimondi, Raynier Devillier, Sabine Furst, Laura Giordano, Barbara Sarina, Jacopo Mariotti…

    Citation: BMC Cancer 2020 20:1140

    Content type: Research article

    Published on:

  25. The recommended cumulative doxorubicin dose in soft tissue sarcoma (STS) treatment was based on cardiotoxicity data from retrospective studies of breast cancer patients. However, the treatment and prognosis of...

    Authors: Zhichao Tian, Yang Yang, Yonghao Yang, Fan Zhang, Po Li, Jiaqiang Wang, Jinpo Yang, Peng Zhang, Weitao Yao and Xin Wang

    Citation: BMC Cancer 2020 20:1139

    Content type: Research article

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  26. Women with an advantaged socioeconomic position (SEP) have a higher risk of developing breast cancer (BC). The reasons for this association do not seem to be limited to reproductive factors and remain to be un...

    Authors: Eloïse Berger, Noële Maitre, Francesca Romana Mancini, Laura Baglietto, Vittorio Perduca, Hélène Colineaux, Sabina Sieri, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Paolo Vineis, Marie-Christine Boutron-Ruault, Gianluca Severi, Raphaële Castagné and Cyrille Delpierre

    Citation: BMC Cancer 2020 20:1138

    Content type: Research article

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  27. Hepatocellular carcinoma (HCC) is among the deadliest forms of cancer. While RNA-binding proteins (RBPs) have been shown to be key regulators of oncogenesis and tumor progression, their dysregulation in the co...

    Authors: Min Wang, Shan Huang, Zefeng Chen, Zhiwei Han, Kezhi Li, Chuang Chen, Guobin Wu and Yinnong Zhao

    Citation: BMC Cancer 2020 20:1136

    Content type: Research article

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  28. The epithelial-mesenchymal transition (EMT) plays a pivotal role in various physiological processes, such as embryonic development, tissue morphogenesis, and wound healing. EMT also plays an important role in ...

    Authors: Zizhen Zhang, Sheng Zheng, Yifeng Lin, Jiawei Sun, Ning Ding, Jingyu Chen, Jing Zhong, Liuhong Shi and Meng Xue

    Citation: BMC Cancer 2020 20:1135

    Content type: Research article

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  29. Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysi...

    Authors: Citrawati Dyah Kencono Wungu, Fis Citra Ariyanto, Gwenny Ichsan Prabowo, Soetjipto and Retno Handajani

    Citation: BMC Cancer 2020 20:1134

    Content type: Research article

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  30. Cervical cancer (CC) is one of the most common gynaecological cancers. The gene signature is believed to be reliable for predicting cancer patient survival. However, there is no relevant study on the relations...

    Authors: Luya Cai, Chuan Hu, Shanshan Yu, Lixiao Liu, Xiaobo Yu, Jiahua Chen, Xuan Liu, Fan Lin, Cheng Zhang, Wenfeng Li and Xiaojian Yan

    Citation: BMC Cancer 2020 20:1133

    Content type: Research article

    Published on:

  31. Previous studies have revealed that nearly 15–20% of selected high-risk T1–2N0 breast cancers developed LRR after mastectomy. This study is aim to indentify the risk factors of locoregional recurrence (LRR) in...

    Authors: Jianyang Wang, Yu Tang, Hao Jing, Guangyi Sun, Jing Jin, Yueping Liu, Yongwen Song, Weihu Wang, Hui Fang, Bo Chen, Shunan Qi, Hua Ren, Ning Li, Yuan Tang, Ningning Lu, Yong Yang…

    Citation: BMC Cancer 2020 20:1132

    Content type: Research article

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  32. Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are malignancies with a leading lethality. With reference to interferons (IFNs) known to mediate antitumor activities, this study inve...

    Authors: Henriette Huschka and Sabine Mihm

    Citation: BMC Cancer 2020 20:1131

    Content type: Research article

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  33. The translational interest in the intratumoral heterogeneity of hepatocellular carcinoma (HCC) has been increasing. The dismal prognosis of this pathology is linked to the features of the HCC harbouring cancer...

    Authors: Jenny Krause, Johann von Felden, Christian Casar, Thorben W. Fründt, Johanna Galaski, Constantin Schmidt, Caroline Jung, Harald Ittrich, Sören A. Weidemann, Till Krech, Asmus Heumann, Jun Li, Lutz Fischer, Guido Sauter, Ansgar W. Lohse, Henning Wege…

    Citation: BMC Cancer 2020 20:1130

    Content type: Research article

    Published on:

  34. The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for gallbladder carcinoma (GBC) came into force since 2018. However, the prognostic precision of this staging system has not been...

    Authors: Wei Jiang, Bingqing Zhao, Yongcheng Li, Dunfeng Qi and Daxing Wang

    Citation: BMC Cancer 2020 20:1129

    Content type: Research article

    Published on:

  35. While immune-checkpoint inhibitors (ICIs) have transformed the field of oncology for advanced-stage cancers, they can lead to serious immune toxicities. Several systematic reviews have evaluated the risk of im...

    Authors: Zahra Karimian, Sandra Mavoungou, Joe-Elie Salem, Florence Tubach and Agnès Dechartres

    Citation: BMC Cancer 2020 20:1128

    Content type: Research article

    Published on:

  36. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer and Birgit Luber

    Citation: BMC Cancer 2020 20:1127

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:1039

  37. An amendment to this paper has been published and can be accessed via the original article.

    Authors: E. B. Elimimian, L. Elson, E. Stone, R. S. Butler, M. Doll, S. Roshon, C. Kondaki, A. Padgett and Z. A. Nahleh

    Citation: BMC Cancer 2020 20:1125

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:899

  38. Schlafen 11 (SLFN11) was recently identified as a dominant determinant of sensitivity to DNA-targeting agents including platinum-based drugs. SLFN11 also reportedly enhances cellular radiosensitivity. In this ...

    Authors: Takuma Kagami, Mihoko Yamade, Takahiro Suzuki, Takahiro Uotani, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Satoshi Baba, Haruhiko Sugimura, Junko Murai, Yves Pommier and Takahisa Furuta

    Citation: BMC Cancer 2020 20:1123

    Content type: Research article

    Published on:

  39. Peritoneal metastasis (PM) in patients with breast (BC) and endometrial cancer (EC) is rare and treatment options are limited. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) has demonstrated efficacy...

    Authors: Günther A. Rezniczek, Urs Giger-Pabst, Omar Thaher and Clemens B. Tempfer

    Citation: BMC Cancer 2020 20:1122

    Content type: Research article

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  40. Lung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cance...

    Authors: Mei Chai and Qingming Shi

    Citation: BMC Cancer 2020 20:1121

    Content type: Research article

    Published on:

  41. Previous research results on the predictive factors of neoadjuvant chemotherapy (NCT) efficacy in breast cancer are inconsistent, suggesting that the ability of a single factor to predict efficacy is insuffici...

    Authors: Shengyu Pu, Ke Wang, Yang Liu, Xiaoqin Liao, Heyan Chen, Jianjun He and Jian Zhang

    Citation: BMC Cancer 2020 20:1120

    Content type: Research article

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  42. Breast cancer (BC) is the second most common type of cancer worldwide. Among targeted therapies for Hormone Receptor-positive (HR+) and Human Epidermal growth factor Receptor 2-negative (HER2) BC, the Cyclin-Dep...

    Authors: Oliviero Marinelli, Emanuela Romagnoli, Federica Maggi, Massimo Nabissi, Consuelo Amantini, Maria Beatrice Morelli, Matteo Santoni, Nicola Battelli and Giorgio Santoni

    Citation: BMC Cancer 2020 20:1119

    Content type: Research article

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  43. We previously reported that low-dose, short-course sunitinib prior to neoadjuvant doxorubicin-cyclophosphamide (AC) normalised tumour vasculature and improved perfusion, but resulted in neutropenia and delayed...

    Authors: Yvonne L. E. Ang, Gwo Fuang Ho, Ross A. Soo, Raghav Sundar, Sing Huang Tan, Wei Peng Yong, Samuel G. W. Ow, Joline S. J. Lim, Wan Qin Chong, Phyu Pyar Soe, Bee Choo Tai, Lingzhi Wang, Boon Cher Goh and Soo-Chin Lee

    Citation: BMC Cancer 2020 20:1118

    Content type: Research article

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  44. Novel agents such as proteasome inhibitors have been developed for several years to treat multiple myeloma. Although multiple myeloma is a low-risk disease for developing tumor lysis syndrome (TLS), treatment ...

    Authors: Masahiro Kondo, Yuji Hotta, Karen Yamauchi, Akimasa Sanagawa, Hirokazu Komatsu, Shinsuke Iida and Kazunori Kimura

    Citation: BMC Cancer 2020 20:1117

    Content type: Research article

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  45. FOLFOXIRI plus bevacizumab is used as a first-line therapy for patients with unresectable or metastatic colorectal cancer. However, there are no clear recommendations for second-line therapy after FOLFOXIRI pl...

    Authors: Hironaga Satake, Koji Ando, Eiji Oki, Mototsugu Shimokawa, Akitaka Makiyama, Hiroshi Saeki, Akihito Tsuji and Masaki Mori

    Citation: BMC Cancer 2020 20:1116

    Content type: Study protocol

    Published on:

  46. In patients with metastatic cancer, the bone is the third-most common site of involvement. Radiation to painful bone metastases results in high rates of pain control and is an integral part of bone metastases ...

    Authors: Daniel B. Rosen, Cory D. Benjamin, Joanna C. Yang, Connor Doyle, Zhigang Zhang, Chris A. Barker, Max Vaynrub, T. Jonathan Yang and Erin F. Gillespie

    Citation: BMC Cancer 2020 20:1115

    Content type: Study protocol

    Published on:

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