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  1. Although many intratumoral biomarkers have been reported to predict clear cell renal cell carcinoma (ccRCC) patient prognosis, combining intratumoral and clinical indicators could predict ccRCC prognosis more ...

    Authors: Chao Wang, Keqin Dong, Yuning Wang, Guang Peng, Xu Song, Yongwei Yu, Pei Shen and Xingang Cui

    Citation: BMC Cancer 2021 21:890

    Content type: Research

    Published on:

  2. The prognostic roles of three lymph node classifications, number of positive lymph nodes (NPLN), log odds of positive lymph nodes (LODDS), and lymph node ratio (LNR) in lung adenocarcinoma are unclear. We aim ...

    Authors: Suyu Wang, Yue Yu, Wenting Xu, Xin Lv, Yufeng Zhang and Meiyun Liu

    Citation: BMC Cancer 2021 21:653

    Content type: Research

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  3. Identifying ineffective practices that have been used in oncology is important in reducing wasted resources and harm. We sought to examine the prevalence of practices that are being used but have been shown in...

    Authors: Alyson Haslam, Jennifer Gill, Tyler Crain, Diana Herrera-Perez, Emerson Y. Chen, Talal Hilal, Myung S. Kim and Vinay Prasad

    Citation: BMC Cancer 2021 21:889

    Content type: Research

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  4. The study aimed to assess resilience and its associated factors in head and neck cancer patients, post-treatment in a low middle income country (LMIC) such as Pakistan.

    Authors: Nida Zahid, Wajeeha Zahid, Wardah Khalid, Iqbal Azam, Mubasher Ikram, Aneesa Hassan, Haissan Iftikar, Shireen Shehzad Bhamani, Adnan Abdul Jabbar, Shabbir Akhtar, Moghira Iqbaluddin Siddiqui, Mohammad Sohail Awan, Nargis Asad and Khabir Ahmad

    Citation: BMC Cancer 2021 21:888

    Content type: Research

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  5. We have proposed a modified, completely intrafascial radical cysprostatectomy (RC) to treat bladder cancer patients with the aim of preserving the patients’ post-surgical urinary control and erectile function....

    Authors: Xiao Wang, Jia Guo, Lei Wang, Min Wang, Xiaodong Weng, Hui Chen and Xiuheng Liu

    Citation: BMC Cancer 2021 21:887

    Content type: Research

    Published on:

  6. Considering the clinical and genetic characteristics, acute lymphoblastic leukemia (ALL) is a rather heterogeneous hematological neoplasm for which current standard diagnostics require various analyses encompa...

    Authors: Wencke Walter, Rabia Shahswar, Anna Stengel, Manja Meggendorfer, Wolfgang Kern, Torsten Haferlach and Claudia Haferlach

    Citation: BMC Cancer 2021 21:886

    Content type: Research

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  7. Up to now, limited researches focused on the association between transcription factor 7-like 2 gene (TF7L2) gene single nucleotide polymorphisms (SNPs) and breast cancer (BC) risk. The aim of this study was to ev...

    Authors: Yang Wang, Xiaojuan Men, Yongxue Gu, Huidong Wang and Zhicai Xu

    Citation: BMC Cancer 2021 21:885

    Content type: Research

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  8. Neuroligin1 (NLGN1) is a main component of excitatory glutamatergic synapses complex and is important for synapse assembly and function. The clinical value of NLGN1 in colorectal cancer (CRC) is not clear.

    Authors: Qian Yu, Xiaojie Wang, Yinghong Yang, Pan Chi, Jianping Huang, Shengliang Qiu, Xin Zheng and Xiaowen Chen

    Citation: BMC Cancer 2021 21:884

    Content type: Research

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  9. To identify subgroups of female breast cancer patients with distinct self-reported employment interference (EI) profiles and determine which demographic, clinical, and symptom characteristics, and quality of l...

    Authors: Raymond Javan Chan, Bruce Cooper, Louisa Gordon, Nicolas Hart, Chia Jie Tan, Bogda Koczwara, Kord M. Kober, Alexandre Chan, Yvette P. Conley, Steven M. Paul and Christine Miaskowski

    Citation: BMC Cancer 2021 21:883

    Content type: Research

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  10. Human papilloma virus infection and tobacco smoking are the major risk factors for cervical cancer. There are limited studies searching other risk factors for cervical cancer and the results are not consistent...

    Authors: Ji Young Kim, Dae Woo Lee, Min Jeong Kim, Jae Eun Shin, Yeun Joo Shin and Hae Nam Lee

    Citation: BMC Cancer 2021 21:880

    Content type: Research

    Published on:

  11. Pralatrexate (PDX) is a novel antifolate approved for the treatment of patients with relapsed/refractory peripheral T-cell lymphoma, but some patients exhibit intrinsic resistance or develop acquired resistanc...

    Authors: Kana Oiwa, Naoko Hosono, Rie Nishi, Luigi Scotto, Owen A. O’Connor and Takahiro Yamauchi

    Citation: BMC Cancer 2021 21:879

    Content type: Research article

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  12. Patterns of failure after treatment of oral and squamous cell carcinomas (OSCC) are diversified, with recurrences being one of the common causes. A special group of patients are sometimes encountered in the ou...

    Authors: Yue He, Zhonglong Liu, Surui Sheng, Weijin Gao, Xiao Tang, Xiaoguang Li and Chunyue Ma

    Citation: BMC Cancer 2021 21:878

    Content type: Research article

    Published on:

  13. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib, have achieved good efficacy in EGFR mutation-positive non-small-cell lung cancer (NSCLC) patients, but eventual drug ...

    Authors: Wanjun Yu, Fei Ye, Xiao Yuan, Yali Ma, Chaoming Mao, Xiaoqin Li, Jian Li, Chunhua Dai, Fenhong Qian, Junrong Li, Xiujuan Fan, Yuepeng Zhou, Deqiang Wang, Zhenhong Guo, Huazhang An, Minghui Zhang…

    Citation: BMC Cancer 2021 21:877

    Content type: Study protocol

    Published on:

  14. m6A is the most prevalent and abundant form of mRNA modifications and is closely related to tumor proliferation, differentiation, and tumorigenesis. In this study, we try to conduct an effective prediction mod...

    Authors: Lianzi Wang, Shubing Zhang, Huimin Li, Yang Xu, Qiang Wu, Jilong Shen, Tao Li and Yuanhong Xu

    Citation: BMC Cancer 2021 21:876

    Content type: Research

    Published on:

  15. Occult metastases in axillary lymph nodes have been reported to be associated with poor prognosis in patients with breast cancer. However, studies on the prognostic value of occult metastases have shown contro...

    Authors: Guixin Wang, Shuhao Zhang, Meiling Wang, Lin Liu, Yaqian Liu, Lianjun Tang, He Bai and Haidong Zhao

    Citation: BMC Cancer 2021 21:875

    Content type: Research

    Published on:

  16. Leptomeningeal metastasis (LM) is a severe complication of advanced non-small cell lung cancer (NSCLC). This retrospective study aimed to investigate the potential use of osimertinib for preventing LM in patie...

    Authors: Xia Wang, Jing Cai, Zhimin Zeng and Anwen Liu

    Citation: BMC Cancer 2021 21:873

    Content type: Research

    Published on:

  17. Despite the progress in assessment and treatment of breast cancer, being diagnosed with it or receiving chemotherapy treatment is still conceived as a traumatic experience. Women develop negative thoughts abou...

    Authors: Aline HAJJ, Roula HACHEM, Rita KHOURY, Souheil HALLIT, Bashar ElJEBBAWI, Fady NASR, Fadi EL KARAK, Georges CHAHINE, Joseph KATTAN and Lydia RABBAA KHABBAZ

    Citation: BMC Cancer 2021 21:872

    Content type: Research

    Published on:

  18. Supervised physical activity interventions improve functional health during cancer survivorship, but remain costly and inaccessible for many. We previously reported on the benefits of a DVD-delivered physical ...

    Authors: Elizabeth A. Salerno, Neha P. Gothe, Jason Fanning, Lindsay L. Peterson, Graham A. Colditz and Edward McAuley

    Citation: BMC Cancer 2021 21:870

    Content type: Research article

    Published on:

  19. Although colorectal cancer (CRC) screening programs reduce CRC incidence and mortality, they are associated with risks in healthy subjects. However, the risk of overtreatment and overdiagnosis has not been det...

    Authors: Joaquín Cubiella, Antía González, Raquel Almazán, Elena Rodríguez-Camacho, Raquel Zubizarreta and Isabel Peña-Rey Lorenzo

    Citation: BMC Cancer 2021 21:869

    Content type: Research article

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  20. Currently, no clinically useful biomarkers for radioresistance are available in head and neck squamous cell carcinoma (HNSCC). This study assesses the usefulness of Cell Line Microarray (CMA) method to enhance...

    Authors: Johannes Routila, Karri Suvila, Reidar Grénman, Ilmo Leivo, Jukka Westermarck and Sami Ventelä

    Citation: BMC Cancer 2021 21:868

    Content type: Research

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  21. This investigator-initiated, open-label, single-arm, single-institute study was conducted to investigate the effectiveness of induction combination chemoradiotherapy and long-term maintenance therapy with temo...

    Authors: Kenichiro Asano, Toshio Fumoto, Masashi Matsuzaka, Seiko Hasegawa, Naoya Suzuki, Kenichi Akasaka, Kosuke Katayama, Akihisa Kamataki, Akira Kurose and Hiroki Ohkuma

    Citation: BMC Cancer 2021 21:867

    Content type: Research article

    Published on:

  22. Lymphovascular space invasion is an independent prognostic factor in early-stage cervical cancer. However, there is a lack of non-invasive methods to detect lymphovascular space invasion. Some researchers foun...

    Authors: Xiaoran Li, Chen Xu, Yang Yu, Yan Guo and Hongzan Sun

    Citation: BMC Cancer 2021 21:866

    Content type: Research article

    Published on:

  23. Cholangiocarcinoma (CCA) is an aggressive disease with poor prognosis. A molecular classification based on mutational, methylation and transcriptomic features could allow identifying tailored therapies to impr...

    Authors: Giuliana Cavalloni, Caterina Peraldo-Neia, Annamaria Massa, Carlo Bergamini, Alessandro Trentini, Giovanni De Rosa, Lorenzo Daniele, Fabiola Ciccosanti, Carlo Cervellati, Francesco Leone and Massimo Aglietta

    Citation: BMC Cancer 2021 21:865

    Content type: Research

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  24. Surgery is an important therapeutic option for brain metastases. Currently, postoperative stereotactic radiosurgery (SRT) leads to 6-month and 1-year local control estimated at 70 and 62% respectively. However...

    Authors: Angeline Ginzac, Guillaume Dupic, Lucie Brun, Ioana Molnar, Mélanie Casile, Xavier Durando, Pierre Verrelle, Jean-Jacques Lemaire, Toufic Khalil and Julian Biau

    Citation: BMC Cancer 2021 21:864

    Content type: Study protocol

    Published on:

  25. Cell-to-cell fusion is emerging as a key element of the metastatic process in various cancer types. We recently showed that hybrids made from the spontaneous merging of pre-malignant (IMR90 E6E7, i.e. E6E7) an...

    Authors: Ariadna Brito, Candice Merle, Pauline Lagarde, Benjamin Faustin, Anne Devin, Lydia Lartigue and Frederic Chibon

    Citation: BMC Cancer 2021 21:863

    Content type: Research

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  26. Here we evaluated the feasibility, efficacy, tolerability, and treatment-mediated immune modulation of neoadjuvant everolimus plus letrozole versus chemotherapy in treating postmenopausal patients with ER-posi...

    Authors: Wei Wu, Jiewen Chen, Heran Deng, Liang Jin, Zhanghai He, Nanyan Rao, Yan Nie, Yandan Yao, Yaping Yang, Fengxi Su and Jieqiong Liu

    Citation: BMC Cancer 2021 21:862

    Content type: Research

    Published on:

  27. To investigate the global expression profile of miRNAs, their impact on cellular signaling pathways, and their association with poor prognostic parameters in African-American (AA) patients with triple negative...

    Authors: Safaa Turkistani, Bruna M. Sugita, Paolo Fadda, Rafael Marchi, Ali Afsari, Tammey Naab, Victor Apprey, Robert L. Copeland Jr, Michael C. Campbell, Luciane R. Cavalli and Yasmine Kanaan

    Citation: BMC Cancer 2021 21:861

    Content type: Research

    Published on:

  28. The psychometric properties of the simplified Chinese version of the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE) have not been assessed. Therefore, we ai...

    Authors: Shan-Shan Yang, Lei Chen, Ying Liu, Hai-Jun Lu, Bo-Jie Huang, Ai-Hua Lin, Ying Sun, Jun Ma, Fang-Yun Xie and Yan-Ping Mao

    Citation: BMC Cancer 2021 21:860

    Content type: Research

    Published on:

  29. Afatinib is one of the standard treatments for patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC). However, data on the use of afatinib in patients with poor performa...

    Authors: Chiao-En Wu, Ching-Fu Chang, Chen-Yang Huang, Cheng-Ta Yang, Chih-Hsi Scott Kuo, Ping-Chih Hsu and John Wen-Cheng Chang

    Citation: BMC Cancer 2021 21:859

    Content type: Research article

    Published on:

  30. Bladder cancer (BC) is a common malignancy neoplasm diagnosed in advanced stages in most cases. It is crucial to screen ideal biomarkers and construct a more accurate prognostic model than conventional clinica...

    Authors: Jianpeng Li, Jinlong Cao, Pan Li, Zhiqiang Yao, Ran Deng, Lijun Ying and Junqiang Tian

    Citation: BMC Cancer 2021 21:858

    Content type: Research

    Published on:

  31. Primary urethral carcinoma (PUC) is a rare genitourinary malignancy with a relatively poor prognosis. The aim of this study was to examine the impact of surgery on survival of patients diagnosed with PUC.

    Authors: Jie Wu, Yu-Chen Wang, Wen-Jie Luo, Bo-Dai, Ding-Wei Ye and Yi-Ping Zhu

    Citation: BMC Cancer 2021 21:857

    Content type: Research article

    Published on:

  32. PTEN is the most frequently lost tumor suppressor in primary prostate cancer (PCa) and its loss is associated with aggressive disease. However, the transcriptional changes associated with PTEN loss in PCa have...

    Authors: Eddie Luidy Imada, Diego Fernando Sanchez, Wikum Dinalankara, Thiago Vidotto, Ericka M. Ebot, Svitlana Tyekucheva, Gloria Regina Franco, Lorelei Ann Mucci, Massimo Loda, Edward Matthew Schaeffer, Tamara Lotan and Luigi Marchionni

    Citation: BMC Cancer 2021 21:856

    Content type: Research article

    Published on:

  33. Fatigue is one of the most common and burdensome symptoms experienced by cancer patients. In interventions intended to reduce fatigue in such patients, fatigability, or perception of fatigue contextualized to ...

    Authors: Min Kyeong Jang, Jeehee Han, Sung Hae Kim, Yun Hee Ko, Soo Yeon Kim and Sue Kim

    Citation: BMC Cancer 2021 21:855

    Content type: Research

    Published on:

  34. Although current therapy for patients with early-stage squamous cell carcinoma of the head and neck (SCCHN) is potentially curative, the recurrence rate is high. Patients with recurrent or metastatic (R/M) SCC...

    Authors: Prianka Singh, Bryan Bennett, Tom Bailey, Gavin Taylor-Stokes, Ivana Rajkovic, Marta Contente, Sharon Curtis and Chris Curtis

    Citation: BMC Cancer 2021 21:854

    Content type: Research

    Published on:

  35. Modified FOLFIRINOX and gemcitabine plus nab-paclitaxel (GEM-NAB) have been recommended as first-line therapies for advanced pancreatic cancer (PC). Due to the lack of evidence to directly compare them, we con...

    Authors: Jiayuan Chen, Qingling Hua, Haihong Wang, Dejun Zhang, Lei Zhao, Dandan Yu, Guoliang Pi, Tao Zhang and Zhenyu Lin

    Citation: BMC Cancer 2021 21:853

    Content type: Research article

    Published on:

  36. This Phase 2a dose expansion study was performed to assess the safety, tolerability and preliminary efficacy of the maximum tolerated dose of the oral histone de-acetylase (HDAC) inhibitor CXD101 in patients w...

    Authors: Stephen W. Booth, Toby A. Eyre, John Whittaker, Leticia Campo, Lai Mun Wang, Elizabeth Soilleux, Daniel Royston, Gabrielle Rees, Murali Kesavan, Catherine Hildyard, Farasat Kazmi, Nick La Thangue, David Kerr, Mark R. Middleton and Graham P. Collins

    Citation: BMC Cancer 2021 21:851

    Content type: Research article

    Published on:

  37. Glioblastoma multiforme (GBM) is a highly lethal, stage IV brain tumour with a prevalence of approximately 2 per 10,000 people globally. The cell surface proteins or surfaceome serve as information gateway in ...

    Authors: Saiful Effendi Syafruddin, Wan Fahmi Wan Mohamad Nazarie, Nurshahirah Ashikin Moidu, Bee Hong Soon and M. Aiman Mohtar

    Citation: BMC Cancer 2021 21:850

    Content type: Research article

    Published on:

  38. Prostate cancer is caused by genomic aberrations in normal epithelial cells, however clinical translation of findings from analyses of cancer cells alone has been very limited. A deeper understanding of the tu...

    Authors: Stefano Mangiola, Patrick McCoy, Martin Modrak, Fernando Souza-Fonseca-Guimaraes, Daniel Blashki, Ryan Stuchbery, Simon P. Keam, Michael Kerger, Ken Chow, Chayanica Nasa, Melanie Le Page, Natalie Lister, Simon Monard, Justin Peters, Phil Dundee, Scott G. Williams…

    Citation: BMC Cancer 2021 21:846

    Content type: Research article

    Published on:

  39. The understanding of molecular changes in mCRC during treatment could be used to personalise therapeutic strategies. The aim of our study was to explore the association of circulating tumour DNA (ctDNA) with c...

    Authors: Ning Jia, Lianpeng Chang, Xin Gao, Xiaohua Shi, Xuelin Dou, Mei Guan, Yajuan Shao, Ningning Li, Yuejuan Cheng, Hongyan Ying, Zhao Sun, Yanping Zhou, Lin Zhao, Jianfeng Zhou and Chunmei Bai

    Citation: BMC Cancer 2021 21:845

    Content type: Research

    Published on:

  40. Glioma is a common type of brain tumor and is classified as low and high grades according to morphology and molecules. Growing evidence has proved that long non-coding RNAs (lncRNAs) play pivotal roles in nume...

    Authors: Tianzao Huang, Yingxian Chen, Yile Zeng, Chaoyang Xu, Jinzhong Huang, Weipeng Hu, Xiangrong Chen and Huangde Fu

    Citation: BMC Cancer 2021 21:844

    Content type: Research article

    Published on:

  41. Patients with lung cancer (LC) have a poor quality of life (QoL) and easily suffer from psychological diseases. Previous studies focused less on the relationship between genetic factors and QoL, depression, an...

    Authors: Yunxiang Tang, Ruike Zhang, Yinan Li, Shuyu Xu, Hao Wang, Jingzhou Xu, Lei Xiao, Yajing Wang, Jing Du, Yujia Huang and Tong Su

    Citation: BMC Cancer 2021 21:842

    Content type: Research

    Published on:

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