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  1. In advanced Renal Cell Carcinoma (aRCC), systemic therapy is the mainstay of treatment, with no or little role for surgery in these patients. Tyrosine kinase inhibitors (TKIs) and immune-oncological (IOs) ther...

    Authors: Tarini Prasad Sahoo, Chirag Desai, Shyam Agarwal, Amit Rauthan, Boman Dhabhar, Ghanshyam Biswas, Sandeep Batra, Rajat Saha, Arun Philip, Vijay Agarwal, Palanki Satya Dattatreya, PN Mohapatra, Chetan Deshmukh, Sagar Bhagat, Saiprasad Patil and Hanmant Barkate
    Citation: BMC Cancer 2023 23:737
    Content type: Research Published on:

  2. Non-metastatic breast cancer treatment is mainly based on surgery, with or without chemotherapy, radiotherapy and/or hormone therapy. To reduce the risk of hormone receptor positive (HR+) disease recurrence, h...

    Authors: François Gernier, Jean-Michel Grellard, Charlotte Dupont, Hervé Castel, Marie Fernette, François Lahaye, Rose-Marie Charles, Tiphaine Leroux, Céline Ory, Audrey Faveyrial, Adeline Morel, George Emile, Christelle Levy, Carine Segura, Djelila Allouache, Alison Johnson…
    Citation: BMC Cancer 2023 23:736
    Content type: Study Protocol Published on:

  3. The centromere protein O (CENPO) is an important member of the centromere protein family. However, the role of CENPO in pan–cancer and immune infiltration has not been reported. Here, we investigated the role ...

    Authors: Yuanbiao Wang, Daowen Ye, Ying Li, Fenghong Lv, Wanbo Shen, Hui Li, Linghan Tian, Zongling Fan, Yanling Li, Yan wang, Feng Li and Yan Chen
    Citation: BMC Cancer 2023 23:735
    Content type: Research Published on:

  4. For locally advanced rectal cancer (LARC), total neoadjuvant therapy (TNT) may enhance tumour response, reduce recurrence, and improve patient compliance compared to upfront surgery. Recent studies have shown ...

    Authors: Min Jung Kim, Dae Won Lee, Hyun-Cheol Kang, Ji Won Park, Seung-Bum Ryoo, Sae-Won Han, Kyung Su Kim, Eui Kyu Chie, Jae Hwan Oh, Woon Kyung Jeong, Byoung Hyuck Kim, Eun Mi Nam and Seung-Yong Jeong
    Citation: BMC Cancer 2023 23:734
    Content type: Study Protocol Published on:

  5. Histone acetylation (HA) is an important and common epigenetic pathway, which could be hijacked by tumor cells during carcinogenesis and cancer progression. However, the important role of HA across human cance...

    Authors: Congkuan Song, Xinfei Liu, Weichen Lin, Kai Lai, Shize Pan, Zilong Lu, Donghang Li, Ning Li and Qing Geng
    Citation: BMC Cancer 2023 23:733
    Content type: Research Published on:

  6. Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation often obtain de novo resistance or develop secondary resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs), wh...

    Authors: Yaya Yu, Zhenzhen Xiao, Chenjing Lei, Changju Ma, Lina Ding, Qing Tang, Yihan He, Yadong Chen, Xuesong Chang, Yanjuan Zhu and Haibo Zhang
    Citation: BMC Cancer 2023 23:732
    Content type: Research Published on:

  7. To assess the cost-effectiveness of cetuximab in combination with chemotherapy fluorouracil, oxaliplatin, and leucovorin (FOLFOX) or fluorouracil, irinotecan and leucovorin (FOLFIRI) compared to standard chemo...

    Authors: Septiara Putri, Siti Rizny F. Saldi, Levina Chandra Khoe, Ery Setiawan, Amila Megraini, Benjarin Santatiwongchai, Ryan R. Nugraha, Vetty Y. Permanasari, Mardiati Nadjib, Sudigdo Sastroasmoro and Armansyah Armansyah
    Citation: BMC Cancer 2023 23:731
    Content type: Research Published on:

  8. Cervical cancer (CC) can be prevented through early detection facilitated by screening as well as an early diagnosis and effective treatment of the precancerous lesions. The present research aimed to determine...

    Authors: Sara Dadipoor, Azin Alavi, Zainab Kader, Shokrollah Mohseni, Hadi Eshaghi Sani Kakhaki and Nahid Shahabi
    Citation: BMC Cancer 2023 23:730
    Content type: Research Published on:

  9. Biliary tract cancer (BTC) is a relatively rare but highly aggressive malignancy. However, there is currently no satisfactory second-line regimen for patients without specific genetic mutations. Nanoparticle a...

    Authors: Nan Zhou, Xiaofen Li, Yu Yang, Sirui Tan, Shunyu Zhang, Qiyue Huang and Hongfeng Gou
    Citation: BMC Cancer 2023 23:729
    Content type: Study Protocol Published on:

  10. Surgical resection followed by adjuvant mFOLFIRINOX (5-fluorouracil with leucovorin, irinotecan, and oxaliplatin) is currently the standard of care for patients with resectable pancreatic cancer. The main conc...

    Authors: J. L. van Dam, E. M. M. Verkolf, E. N. Dekker, B. A. Bonsing, S. O. Bratlie, L. A. A. Brosens, O. R. Busch, L. M. J. W. van Driel, C. H. J. van Eijck, S. Feshtali, P. Ghorbani, D. J. A. de Groot, J. W. B. de Groot, B. C. M. Haberkorn, I. H. de Hingh, B. van der Holt…
    Citation: BMC Cancer 2023 23:728
    Content type: Study Protocol Published on:

  11. Low grade glioma (LGG) is considered a heterogeneous tumor with highly variable survival and limited efficacy of immunotherapy. To identify high-risk subsets and apply immunotherapy effectively in LGG, the sta...

    Authors: Jinna Li, Qing Guo and Rui Xing
    Citation: BMC Cancer 2023 23:727
    Content type: Research Published on:

  12. Trifluridine/tipiracil (FTD/TPI) prolongs survival in the third- or later-line treatment for advanced gastric cancer (GC), esophagogastric junction (EGJ) adenocarcinoma, and colorectal cancer. While single-arm...

    Authors: Naoki Takahashi, Hiroki Hara, Kengo Nagashima, Kenro Hirata, Toshiki Masuishi, Toshihiko Matsumoto, Hisato Kawakami, Kentaro Yamazaki, Shuichi Hironaka, Narikazu Boku and Kei Muro
    Citation: BMC Cancer 2023 23:726
    Content type: Study Protocol Published on:

  13. Bladder cancer (BLCA) represents a highly heterogeneous disease characterized by distinct histological, molecular, and clinical features, whose tumorigenesis and progression require aberrant metabolic reprogra...

    Authors: Yun Cai, Yifei Cheng, Ziyu Wang, Lu Li, Zhengtao Qian, Wei Xia and Weiwei Yu
    Citation: BMC Cancer 2023 23:725
    Content type: Research Published on:

  14. Current radiotherapy guidelines and consensus statements uniformly recommend elective region irradiation (ERI) as the standard strategy for nasopharyngeal carcinoma (NPC). However, given the scarcity of skip-m...

    Authors: Yang Liu, Yaqian Han, Feng Liu, Desheng Hu, Zhijian Chen, Peiguo Wang, Jingao Li, Jiyong Qin, Feng Jin, Yexiong Li, Jingbo Wang and Junlin Yi
    Citation: BMC Cancer 2023 23:724
    Content type: Study protocol Published on:

  16. It is widely accepted that chronic inflammatory bowel diseases significantly higher a risk for colorectal cancer development. Among different types of treatments for patients with colon cancer, novel protein-b...

    Authors: Mariam Al-Omari, Tareq Al-Omari, Nesreen Batainah, Khaled Al-Qauod, Beata Olejnicka and Sabina Janciauskiene
    Citation: BMC Cancer 2023 23:722
    Content type: Research Published on:

  17. SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss an...

    Authors: Hira Javaid, Alessandro Barberis, Olga Chervova, Isar Nassiri, Vitaly Voloshin, Yusuke Sato, Seishi Ogawa, Benjamin Fairfax, Francesca Buffa and Timothy C. Humphrey
    Citation: BMC Cancer 2023 23:721
    Content type: Research Published on:

  18. The molecular subtypes of endometrial carcinoma are significantly correlated with survival outcomes and can guide surgical methods and postoperative adjuvant therapy. Among them, the TP53mut subtype has the wo...

    Authors: Wei Wang, Xiaoting Li, Yunong Gao, Hong Zheng and Min Gao
    Citation: BMC Cancer 2023 23:720
    Content type: Research Published on:

  19. To determine the role and rational application of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) adjuvant therapy in patients with completely resected stage IB-IIIA EGFR-mutant non-small...

    Authors: Shu-Ling Zhang, Xiao-Fang Yi, Le-Tian Huang, Li Sun, Jie-Tao Ma and Cheng-Bo Han
    Citation: BMC Cancer 2023 23:719
    Content type: Research Published on:

  21. The treatment of non-small cell lung cancer (NSCLC) is challenging due to immune tolerance and evasion. Salidroside (SAL) is an extract in traditional Chinese medicine and has a potential antitumor effect. How...

    Authors: Zexin Wen, Tong Liu, Yanli Zhang, Qiujuan Yue, Hang Meng, Yijie He, Yi Yang, Minghao Li, Jianwen Zheng and Wei Lin
    Citation: BMC Cancer 2023 23:717
    Content type: Research Published on:

  22. TUBA1C is an α-tubulin isoform involved in mitosis, and its dysregulation has been implicated in tumor progression. There is still no clear understanding of its role in bladder urothelial carcinoma (BLCA).

    Authors: Yi Jiang, Chao Zhu, Haoxuan Huang, Gaomin Huang, Bin Fu and Xiaoqing Xi
    Citation: BMC Cancer 2023 23:716
    Content type: Research Published on:

  23. Radical resection plus lymph node dissection is a common treatment for patients with T1-3N0M0 non-small cell lung cancer (NSCLC). Few models predicted the survival outcomes of these patients. This study aimed to ...

    Authors: Weijian Mei, Wang Yao, Zhengbo Song, Wenjie Jiao, Lianxin Zhu, Qinghua Huang, Chaolun An, Jianguang Shi, Guiping Yu, Pingli Sun, Yinbin Zhang, Jianfei Shen, Chunwei Xu, Han Yang, Qian Wang and Zhihua Zhu
    Citation: BMC Cancer 2023 23:715
    Content type: Research Published on:

  24. Precise prognostication is the key to optimum and effective treatment planning for early-stage hormone receptor (HR) positive, HER2/neu negative breast cancer patients. Differences in the breast cancer inciden...

    Authors: Purvish Parikh, Govind Babu, Randeep Singh, Vamshi Krishna, Amit Bhatt, Indu Bansal, Senthil Rajappa, Tarini Prasad Sahoo, Shyam Aggarwal, Ajay Bapna, Ghanshyam Biswas, SP Somashekhar, Jyoti Bajpai, Vashishtha Maniar, Sharad Desai, T Raja…
    Citation: BMC Cancer 2023 23:714
    Content type: Research Published on:

  25. Glioblastoma (GBM), a malignant brain tumor, has poor survival outcomes due to recurrence or drug resistance. We found that SH3GLB1 is a crucial factor for cells to evade temozolomide (TMZ) cytotoxicity throug...

    Authors: Chia-Hung Chien, Chien-Cheng Lai, Jian-Ying Chuang, Jui-Mei Chu, Chan-Chuan Liu and Kwang-Yu Chang
    Citation: BMC Cancer 2023 23:713
    Content type: Research Published on:

  26. Endometrial Cancer (EC) is one of the most prevalent malignancies that affect the female population globally. In the context of immunotherapy, Tumor Mutation Burden (TMB) in the DNA polymerase epsilon (POLE) s...

    Authors: Qing Tan, Qian Wang, Suoqin Jin, Fuling Zhou and Xiufen Zou
    Citation: BMC Cancer 2023 23:712
    Content type: Research Published on:

  27. Nanoliposomal irinotecan (nal-IRI) plus 5-fluorouracil (5-FU)/levo-leucovorin (Levo-LV) was approved for unresectable pancreatic cancer (UR-PC) in March 2020 in Japan. Levo-LV is administered by intravenous infus...

    Authors: Ryoji Takada, Kenji Ikezawa, Takuo Yamai, Ko Watsuji, Yusuke Seiki, Yasuharu Kawamoto, Takeru Hirao, Sena Higashi, Makiko Urabe, Yugo Kai, Tasuku Nakabori, Hiroyuki Uehara, Michiyo Kotani, Toshinari Yagi, Miho Kimura, Keisuke Nozaki…
    Citation: BMC Cancer 2023 23:711
    Content type: Research Published on:

  28. Several cancer immunotherapies that target the PD-L1/PD-1 pathway show promising clinical activity in patients with hepatocellular carcinoma (HCC). However, the standard of care in first-line treatment with at...

    Authors: Angélique Vienot, Marion Jacquin, Magali Rebucci-Peixoto, Dimitri Pureur, François Ghiringhelli, Eric Assenat, Pascal Hammel, Olivier Rosmorduc, Morgane Stouvenot, Manon Allaire, Mohamed Bouattour, Hélène Regnault, Serge Fratte, Eric Raymond, Emilie Soularue, Stéphanie Husson-Wetzel…
    Citation: BMC Cancer 2023 23:710
    Content type: Study Protocol Published on:

  29. The brain is a common site for cancer metastases. In case of large and/or symptomatic brain metastases, neurosurgical resection is performed. Adjuvant radiotherapy is a standard procedure to minimize the risk ...

    Authors: Maria Waltenberger, Denise Bernhardt, Christian Diehl, Jens Gempt, Bernhard Meyer, Christoph Straube, Benedikt Wiestler, Jan J. Wilkens, Claus Zimmer and Stephanie E. Combs
    Citation: BMC Cancer 2023 23:709
    Content type: Study protocol Published on:

  30. In this phase Ib/II open-label study, tumor immune suppression was targeted in patients with advanced refractory solid tumors and patients with recurrent/refractory non-small cell lung cancer (NSCLC) using gal...

    Authors: Ernest Nadal, Mansoor Saleh, Santiago Ponce Aix, Maria Ochoa-de-Olza, Sandip Pravin Patel, Scott Antonia, Yumin Zhao, Ivelina Gueorguieva, Michael Man, Shawn T. Estrem, Jiangang Liu, Emin Avsar, Wen Hong Lin, Karim A. Benhadji, Leena Gandhi, Susan C. Guba…
    Citation: BMC Cancer 2023 23:708
    Content type: Research Published on:

  31. Circulating tumor cells (CTCs) have been a non-invasive technique which allows investigation of tumor characteristics. The purpose of this study was to investigate the relationship between circulating tumor ce...

    Authors: Yuhao He, Xinxin He, Yubo Zhou and Shanshan Luo
    Citation: BMC Cancer 2023 23:707
    Content type: Research Published on:

  32. This study examines prognostic value of preoperative serum bilirubin, including unconjugated bilirubin (UCB), conjugated bilirubin (CB), and total bilirubin (TB), in esophageal squamous cell carcinoma (ESCC) p...

    Authors: Xiancong Huang, Yang Chen, Huan Yang, Ruting Wang and Zhongjian Chen
    Citation: BMC Cancer 2023 23:706
    Content type: Research Published on:

  33. In breast cancer patients body image (BI) is a crucial aspect of quality of life (QoL). This study examined the postoperative impact of different surgical approaches on long-term BI analyzing real-world data t...

    Authors: Melissa Afshar-Bakshloo, Sarah Albers, Chiara Richter, Ottilia Berninger, Jens-Uwe Blohmer, Robert Roehle, Dorothee Speiser and Maria Margarete Karsten
    Citation: BMC Cancer 2023 23:705
    Content type: Research Published on:

  35. Overexpression of Twist1, one of the epithelial-mesenchymal transition-transcription factors (EMT-TFs), is associated with hepatocellular carcinoma (HCC) metastasis. Pelitinib is known to be an irreversible ep...

    Authors: Sewoong Lee, Eunjeong Kang, Unju Lee and Sayeon Cho
    Citation: BMC Cancer 2023 23:703
    Content type: Research Published on:

  36. To compare the clinical value of recombinant human granulocyte colony-stimulating factor (rhG-CSF) and pegylated rhG-CSF(PEG-rhG-CSF) in early-stage breast cancer (EBC) patients receiving adjuvant chemotherapy...

    Authors: Yantao Jiang, Ju Zhang, Jianxin Zhong, Hao Liao, Jiayang Zhang, Yaxin Liu, Yuehua Liang and Huiping Li
    Citation: BMC Cancer 2023 23:702
    Content type: Research Published on:

  38. The COVID-19 pandemic was managed in Aotearoa New Zealand (NZ) by a COVID-19 elimination policy, involving border closure and an initial national lockdown. This was different to most other countries including ...

    Authors: Helen Mitchell, Jennifer Mclean, Anna T Gavin, Otto Visser, Elinor Millar, Tessa Luff and Damien Bennett
    Citation: BMC Cancer 2023 23:700
    Content type: Research Published on:

  39. Drug resistance is a major cause of the inefficacy of conventional cancer therapies, and often accompanied by severe side effects. Thus, there is an urgent need to develop novel drugs with low cytotoxicity, hi...

    Authors: Youssef T. Abdou, Sheri M. Saleeb, Khaled M. A. Abdel-Raouf, Mohamed Allam, Mustafa Adel and Asma Amleh
    Citation: BMC Cancer 2023 23:699
    Content type: Research Published on:

  41. Authors: Qingwu Du, Xiaoyue Wu, Kunning Zhang, Fuliang Cao, Gang Zhao, Xiaoying Wei, Zhoubo Guo, Yang Li, Jie Dong, Tian Zhang, Wencheng Zhang, Ping Wang, Xi Chen and Qingsong Pang
    Citation: BMC Cancer 2023 23:697
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2023 23:681

  42. Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with a high prevalence and poor prognosis. It is an urgent problem to deeply understand the molecular mechanism of ESCC and ...

    Authors: Honggang Liu, Menglong Jiang, Fenghui Ma, Jiapei Qin, Xin Zhou, Liqun Xu, Xiaolong Yan and Tao Jiang
    Citation: BMC Cancer 2023 23:696
    Content type: Research Published on:

  43. The site of lymph node metastasis (LNM) may affect the prognosis of patients with esophageal squamous cell carcinoma (ESCC). To investigate the prognoses of pararespiratory and paradigestive LNM and to propose...

    Authors: Dong Tian, Kai-Yuan Jiang, Yu-Shang Yang, Hao-Ji Yan, Rui-Xuan Yu, Heng Huang, Shun-Hai Jian, Hai-Ning Zhou, Hong-Ying Wen and Long-Qi Chen
    Citation: BMC Cancer 2023 23:695
    Content type: Research Published on:

  44. The Pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) has longer half-life and is given once only, which is more comfortable for patients. We aimed to evaluate the efficacy of mec...

    Authors: Jingjing Wen, Qiaolin Zhou, Lin Shi, Fang Xu, Yiping Liu, Jing Su, Ya Zhang, Wen Qu and Jing Yue
    Citation: BMC Cancer 2023 23:694
    Content type: Research Published on:

  46. As a component of membrane lipids and the precursor of oxysterols and steroid hormones, reprogrammed cholesterol metabolism contributes to the initiation and progression of multiple cancers. Thus, we aim to fu...

    Authors: Rui Tao, Ruoyu Huang, Jingchen Yang, Jiangfei Wang and Kuanyu Wang
    Citation: BMC Cancer 2023 23:692
    Content type: Research Published on:

  47. Although 80% of patients with metastatic colorectal cancer (CRC) experience liver metastases, only 10–25% undergo resection at the time of diagnosis. Even in initially unresectable conditions, if appropriate t...

    Authors: Ji Su Kim, Hyunwook Kim, Seo Young Lee, Yoon Dae Han, Kichang Han, Byung Soh Min, Man-Deuk Kim, Jong Yun Won, Seung-Hoon Beom, Sang Joon Shin, Han Sang Kim, Dai Hoon Han and Joong Bae Ahn
    Citation: BMC Cancer 2023 23:691
    Content type: Study protocol Published on:

  48. Our previous work showed that KRAS activation in gastric cancer cells leads to activation of an epithelial-to-mesenchymal transition (EMT) program and generation of cancer stem-like cells (CSCs). Here we analy...

    Authors: Changhwan Yoon, Jun Lu, Yukyung Jun, Yun-Suhk Suh, Bang-Jin Kim, Jacob E. Till, Jong Hyun Kim, Sara H. Keshavjee, Sandra Ryeom and Sam S. Yoon
    Citation: BMC Cancer 2023 23:690
    Content type: Research Published on:

  49. Despite recent advances in research, there are still critical lacunae in our basic understanding of the cause, pathogenesis, and natural history of many cancers, especially heterogeneity in patient response to...

    Authors: Swati Chitrangi, Pooja Vaity, Aishwarya Jamdar and Shweta Bhatt
    Citation: BMC Cancer 2023 23:689
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2023 23:768

  50. SETD2 protects against genomic instability via maintenance of homologous recombination repair (HRR) and mismatch repair (MMR) in neoplastic cells. However, it remains unclear whether SETD2 dysfunction is a comple...

    Authors: Xiaobin Zheng, Jing Lin, Jiani Xiong, Yanfang Guan, Bin Lan, Yi Li, Xuan Gao, Zhaodong Fei, Lisha Chen, Lizhu Chen, Ling Chen, Gang Chen, Zengqing Guo, Xin Yi, Weiguo Cao, Xinghao Ai…
    Citation: BMC Cancer 2023 23:686
    Content type: Research Published on:

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