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  1. Chemoradiotherapy (CRT), which might affect the autonomic system, is the mainstay therapy for advanced esophageal squamous cell carcinoma (ESCC). Autonomic dysfunction has been found to possibly lead to cancer...

    Authors: Chen-Ling Tang, Wei-Chung Tsai, Jui-Ying Lee, Yao-Kuang Wang, Yi-Hsun Chen, Yu-Wei Liu, Ming-Chieh Lin, Pen-Tzu Fang, Yu-Ling Huang and I-Chen Wu
    Citation: BMC Cancer 2022 22:1086
  2. Cancer therapy has evolved from non-specific cytotoxic agents to a selective, mechanism-based approach that includes targeted agents and immunotherapy. Although the response to targeted therapies for unresecta...

    Authors: Teng-Kai Yang, Ya-Fang Yu, Chiao-Ling Tsai, Hsing-Ju Li, Po-Sheng Yang, Kai-Wen Huang and Jason Chia-Hsien Cheng
    Citation: BMC Cancer 2022 22:1085
  3. This study aimed to determine whether drug doses per kilogram of lean body mass (LBM) were associated with dose-limiting toxicity (DLT) events in head and neck cancer (HNC) patients.

    Authors: Chuan-Jen Hung, Bor-Hwang Kang, Keng-Ming Chang, Ying-Ying Kang, Chun-Hao Yin and Ching-Chih Lee
    Citation: BMC Cancer 2022 22:1084
  4. To review our long-term clinical experience, analyze the failure patterns, and give suggestions for target volume delineation of carcinoma showing thymus-like differentiation (CASTLE) treated with intensity-mo...

    Authors: Fang-Fang Kong, Guang-Sen Pan, Rui-Ping Zhai, Cheng-Run Du, Xia-Yun He, Chun-Ying Shen, Xue-Guan Lu, Tuan-Qi Sun, Yu Wang, Qing-Hai Ji, Chao-Su Hu and Hong-Mei Ying
    Citation: BMC Cancer 2022 22:1083
  5. The tumour–stroma ratio (TSR) is identified as a promising prognostic parameter for breast cancer, but the cutoff TSR value is mostly assessed by visual assessment, which lacks objective measurement. The aims ...

    Authors: Dandan Yan, Xianli Ju, Bin Luo, Feng Guan, Huihua He, Honglin Yan and Jingping Yuan
    Citation: BMC Cancer 2022 22:1082
  6. HER2 expression has a prognostic and predictive impact in early-stage breast cancer (BC). HER2 positive BC (immunohistochemistry (IHC) score 3 + or 2 + with in situ hybridization (ISH) amplification) are treat...

    Authors: François Cherifi, Angélique Da Silva, Alison Johnson, Cécile Blanc-Fournier, Olivia Abramovici, Antonin Broyelle, Christelle Levy, Djelila Allouache, Ioana Hrab, Carine Segura, Adeline Morel, Maud Villemin, Clémence Boscher, Coraline Dubot-Poitelon, Pauline Rottier, Justine Lequesne…
    Citation: BMC Cancer 2022 22:1081
  7. Systemic inflammation is currently regarded as a hallmark of cancer. This study aimed to accurately clarify the prognostic value of various inflammatory markers in patients with stage IV cancer.

    Authors: He-Yang Zhang, Hai-Lun Xie, Guo-Tian Ruan, Qi Zhang, Yi-Zhong Ge, Xiao-Yue Liu, Meng Tang, Meng-Meng Song, Shi-Qi Lin, Ming Yang, Xiao-Wei Zhang, Hong-Xia Xu, Chun-Hua Song and Han-Ping Shi
    Citation: BMC Cancer 2022 22:1080
  8. Radiation therapy is one of the standard methods in the treatment of breast cancer. Radiotherapy-induced dermatitis (RID) is a common complication of radiotherapy (RT) resulting in less tolerance in RT and eve...

    Authors: Mohsen Nabi-Meybodi, Adeleh Sahebnasagh, Zahra Hakimi, Masoud Shabani, Ali Asghar Shakeri and Fatemeh Saghafi
    Citation: BMC Cancer 2022 22:1079
  9. The surgical efficacy and prognostic outcomes of patients with unspecific malignant bone tumors (UMBTs) remain unclear. The study is to address: 1) What are the clinicopathological features and prognostic dete...

    Authors: Shaohui He, Runyi Jiang, Haitao Sun, Jian Yang, Chen Ye, Weibo Liu, Xinghai Yang, Xiaopan Cai and Jianru Xiao
    Citation: BMC Cancer 2022 22:1078
  10. Various cancer stem cell (CSC) biomarkers and the genes encoding them in head and neck squamous cell carcinoma (HNSCC) have been identified and evaluated. However, the validity of these factors in the prognosi...

    Authors: Su Il Kim, Seon Rang Woo, Joo Kyung Noh, Min Kyeong Lee, Young Chan Lee, Jung Woo Lee, Moonkyoo Kong, Seong-Gyu Ko and Young-Gyu Eun
    Citation: BMC Cancer 2022 22:1077
  11. There is growing interest in the collection and use of patient-reported outcome measures (PROMs) to support clinical decision making in patients with non-small cell lung cancer (NSCLC). However, an overview of...

    Authors: Kuan Liao, Tianxiao Wang, Jake Coomber-Moore, David C Wong, Fabio Gomes, Corinne Faivre-Finn, Matthew Sperrin, Janelle Yorke and Sabine N van der Veer
    Citation: BMC Cancer 2022 22:1076
  12. Coagulation and fibrinolysis are distinct processes that are highly correlated. Cells control coagulation and fibrinolysis by expression of tissue factor and urokinase-type plasminogen activator receptor on th...

    Authors: Kunihiro Asanuma, Tomoki Nakamura, Takayuki Okamoto, Tomohito Hagi, Kouji Kita, Koichi Nakamura, Yumi Matsuyama, Keisuke Yoshida, Yumiko Asanuma and Akihiro Sudo
    Citation: BMC Cancer 2022 22:1075
  13. Microbiome dysbiosis is an important contributing factor in tumor development and thus may be a risk predictor for human malignancies. In the United States, women with Hispanic/Latina (HIS) and African America...

    Authors: Kunwar Somesh Vikramdeo, Shashi Anand, Jennifer Young Pierce, Ajay Pratap Singh, Seema Singh and Santanu Dasgupta
    Citation: BMC Cancer 2022 22:1074
  14. Paclitaxel (PTX), a first-line therapy for triple negative breast cancers (TNBC) induces anti-tumor activity by microtubule stabilization and inhibition of cell division. Its dose-limiting toxicity and short h...

    Authors: Brittany M. Haynes, Kristen Cunningham and Malathy P. V. Shekhar
    Citation: BMC Cancer 2022 22:1073
  15. Although there is broad consensus that only a subset of CIN3 will progress to cancer, there is currently no surefire way to predict which CIN3 will regress. Understanding the natural history of CIN3 is importa...

    Authors: Maria Teresa Bruno, Nazario Cassaro, Gabriele Mazza, Arianna Guaita and Sara Boemi
    Citation: BMC Cancer 2022 22:1072
  16. We recently reported the relapse-free survival (RFS) significance of the combination of CD4+ and forkhead box P3+ (FOXP3) T-cell densities identified by immunohistochemistry in patients with stage I, II, and III ...

    Authors: Yuki Nakagami, Shoichi Hazama, Nobuaki Suzuki, Shin Yoshida, Shinobu Tomochika, Hiroto Matsui, Yoshitaro Shindo, Yukio Tokumitsu, Satoshi Matsukuma, Yusaku Watanabe, Michihisa Iida, Ryouichi Tsunedomi, Shigeru Takeda, Tomonobu Fujita, Yutaka Kawakami, Hiroyuki Ogihara…
    Citation: BMC Cancer 2022 22:1071
  17. Breast cancer (BC) is one of the most prevalent cancers worldwide but its etiology remains unclear. Obesity is recognized as a risk factor for BC, and many obesity-related genes may be involved in its occurren...

    Authors: Liyuan Liu, Wenli Zhai, Fei Wang, Lixiang Yu, Fei Zhou, Yujuan Xiang, Shuya Huang, Chao Zheng, Zhongshang Yuan, Yong He, Zhigang Yu and Jiadong Ji
    Citation: BMC Cancer 2022 22:1070
  18. The protein kinases CK2 and PIM-1 are involved in cell proliferation and survival, the cell cycle, and drug resistance, and they are found overexpressed in virtually all types of human cancer, including breast...

    Authors: Mirosława Koronkiewicz, Zygmunt Kazimierczuk and Andrzej Orzeszko
    Citation: BMC Cancer 2022 22:1069
  19. Tumor necrosis factor alpha-induced protein 2 (TNFAIP2), a TNFα-inducible gene, appears to participate in inflammation, immune response, hematopoiesis, and carcinogenesis. However, the potential role of TNFAIP2 i...

    Authors: Mei-si Lin, Hui-Yun Zhong, Rita Lok-Hay Yim, Qi-Yan Chen, Hong-ling Du, Hao-qi He, Ke Lin, Peng Zhao, Ru Gao, Fei Gao and Min-Yue Zhang
    Citation: BMC Cancer 2022 22:1068
  20. Tamoxifen is one of the fundamental pillars of adjuvant endocrine therapy for hormone receptor-positive breast cancer; however, 30–50% of patients receiving tamoxifen experience tumor relapse. CYP2D6, encoded ...

    Authors: Wouroud Ismail Al-khalil, Lana Al-Salhi, Sara Rijjal, Majd Aljamali and Lama A. Youssef
    Citation: BMC Cancer 2022 22:1067
  21. Pulmonary pleomorphic carcinoma (PPC) is a rare type of non-small cell lung cancer characterized by high malignancy and a poor prognosis. PPC is associated with a high frequency of postoperative relapse, and s...

    Authors: Kensuke Kojima, Saki Imai, Hironobu Samejima, Ayako Fujiwara, Toshiteru Tokunaga, Hyungeun Yoon and Kyoichi Okishio
    Citation: BMC Cancer 2022 22:1066
  22. Activated mutations in NOTCH1 are drivers of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which suppresses the function of NOTCH1, is expected to be a molecular-targeted age...

    Authors: Shinsuke Suzuki, Sawako Hourai, Kimiharu Uozumi, Yuichirou Uchida, Makoto Yoshimitsu, Hachiman Miho, Naomichi Arima, Shin-ichi Ueno and Kenji Ishitsuka
    Citation: BMC Cancer 2022 22:1065
  23. C–C chemokine receptor type 7 (CCR7) participates in chemotactic and metastatic responses in various cancers, including in esophageal squamous cell carcinoma (ESCC). The microRNA (miRNA) let-7a suppresses migr...

    Authors: Masahiro Yura, Kazumasa Fukuda, Satoru Matsuda, Tomoyuki Irino, Rieko Nakamura, Hirofumi Kawakubo, Hiroya Takeuchi and Yuko Kitagawa
    Citation: BMC Cancer 2022 22:1064
  24. Although penile cancer (PC) is uncommon in developed countries, it is widespread in developing countries. The state of Maranhão (Northeast, Brazil) has the highest global incidence recorded for PC, and, despit...

    Authors: Antonio Augusto Lima Teixeira Júnior, Syomara Pereira da Costa Melo, Jaqueline Diniz Pinho, Thaís Bastos Moraes Sobrinho, Thalita Moura Silva Rocha, Denner Rodrigo Diniz Duarte, Liseana de Oliveira Barbosa, Wesliany Everton Duarte, Marta Regina de Castro Belfort, Kelly Gomes Duarte, Antonio Lima da Silva Neto, José de Ribamar Rodrigues Calixto, Lúcio Cristiano Paiva Paiva, Francisco Sérgio Moura Silva do Nascimento, Antonio Machado Alencar Junior, André Salim Khayat…
    Citation: BMC Cancer 2022 22:1063
  25. Current pre-operative Sentinel Lymph Node (SLN) mapping using dual tracing is associated with drawbacks (radiation exposure, logistic challenges). Superparamagnetic iron oxide (SPIO) is a non-inferior alternat...

    Authors: Loeki Aldenhoven, Caroline Frotscher, Rachelle Körver-Steeman, Milou H. Martens, Damir Kuburic, Alfred Janssen, Geerard L. Beets and James van Bastelaar
    Citation: BMC Cancer 2022 22:1062
  26. The purpose of this study was to compare the diagnostic value of serum oligosaccharide chain (G-test), alpha-fetoprotein (AFP) and aspartic aminotransferase to alanine aminotransferase ratios (AAR), both alone...

    Authors: Wentao Zhu, Pei Shi, An Liang, Ying Zhu, Jiwei Fu, Songsong Yuan and Xiaoping Wu
    Citation: BMC Cancer 2022 22:1061
  27. We investigated whether partner (spouse or intimate partner) engagement in colorectal cancer (CRC) surveillance is associated with patient receipt of surveillance.

    Authors: Christine M. Veenstra, Katrina R. Ellis, Paul Abrahamse, Kevin C. Ward, Arden M. Morris and Sarah T. Hawley
    Citation: BMC Cancer 2022 22:1060
  28. The distribution of lymphoma subtypes differs strikingly by geographic variations. However, there is limited information on this research in northern Iran. This study aims to evaluate the incidence, subtype, a...

    Authors: Javad Jalili, Amir Vahedi, Amin Danandehmehr, Parya Aynechi, Ali Esfahani, Yousef Roosta, Hooman Nateghian, Amirhosein Ghafouri Asbagh and Fateme Hajihoseinlou
    Citation: BMC Cancer 2022 22:1059
  29. It is crucial to determine feasibility of risk-stratified screening to facilitate successful implementation. We introduced risk-stratification (BC-Predict) into the NHS Breast Screening Programme (NHSBSP) at t...

    Authors: Rachel Hawkins, Lorna McWilliams, Fiona Ulph, D Gareth Evans and David P French
    Citation: BMC Cancer 2022 22:1058
  30. Despite today’s advances in the treatment of cancer, breast cancer-related mortality remains high, in part due to the lack of effective targeted therapies against breast tumor types that do not respond to stan...

    Authors: Carolina Di Benedetto, Justin Oh, Zainab Choudhery, Weiquan Shi, Gilmer Valdes and Paola Betancur
    Citation: BMC Cancer 2022 22:1056
  31. Increasing evidence suggests that cancer-derived extracellular vesicles (EVs) alter the phenotype and functions of fibroblasts and trigger the reprogramming of normal fibroblasts into cancer-associated fibrobl...

    Authors: Lilite Sadovska, Pawel Zayakin, Cristina Bajo-Santos, Edgars Endzeliņš, Jānis Auders, Laura Keiša, Juris Jansons, Vilnis Lietuvietis and Aija Linē
    Citation: BMC Cancer 2022 22:1055
  32. A majority of patients undergoing curative intent surgery for pancreatic ductal adenocarcinoma (PDAC) will unfortunately develop recurrent disease. Treatment outcomes for patients with metastatic disease remai...

    Authors: Laura Miotke, Christopher Nevala-Plagemann, Jian Ying, Vaia Florou, Benjamin Haaland and Ignacio Garrido-Laguna
    Citation: BMC Cancer 2022 22:1054
  33. As a negative co-stimulatory molecule of the B7 family, B7-H4 has recently attracted increased attention. However, the clinical value of B7-H4 in colorectal cancer (CRC) remains controversial and requires furt...

    Authors: Xiaotian Yan, Bo Hong, Jie Feng, Yuanqing Jin, Mengting Chen, Fugang Li and Yun Qian
    Citation: BMC Cancer 2022 22:1053
  34.  Screening recommendations for colorectal cancer (CRC) are mainly based on family history rather than lifestyle risk factors. We aimed to assess and compare risk factors for colorectal neoplasm (CRN) and evalu...

    Authors: Shuyuan Wang, Zhen Yuan, Yuqi Wang, Xuanzhu Zhao, Weifeng Gao, Hongzhou Li, Yuanshun Zhao, Zili Zhang, Shuiqing Liang, Zhaoce Liu, Qinghuai Zhang, Hong Ma, Xipeng Zhang, Wei Cui and Chunze Zhang
    Citation: BMC Cancer 2022 22:1051
  35. Uterine sarcomas are rare and aggressive gynaecologic malignancies, characterized by a relatively high recurrence rate and poor prognosis. The aim of this study was to investigate the clinicopathological featu...

    Authors: Fang Wang, Xinyue Dai, Huijun Chen, Xiaoli Hu and Yuanqiu Wang
    Citation: BMC Cancer 2022 22:1050
  36. Cholesterol and lipids play an important role in sustaining tumor growth and metastasis in a large variety of cancers. ANGPTL3 and PCSK9 modify circulating cholesterol levels, thus availability of lipids to pe...

    Authors: Emilie Wong Chong, France-Hélène Joncas, Nabil G. Seidah, Frédéric Calon, Caroline Diorio and Anne Gangloff
    Citation: BMC Cancer 2022 22:1049
  37. The combination of immune-checkpoint inhibitors with chemotherapy has become the standard of treatment for non-small cell lung cancer (NSCLC) patients. However, the association between therapeutic efficacy and...

    Authors: Kana Kurokawa, Yoichiro Mitsuishi, Naoko Shimada, Yuta Kawakami, Keita Miura, Taichi Miyawaki, Tetsuhiko Asao, Ryo Ko, Takehito Shukuya, Rina Shibayama, Shuko Nojiri and Kazuhisa Takahashi
    Citation: BMC Cancer 2022 22:1047
  38. Multiple mutation (MM) within a single gene has recently been reported as a mechanism involved in carcinogenesis. The present study investigated the clinical significance of MMs in hepatocellular carcinoma (HCC).

    Authors: Taisuke Imamura, Yukiyasu Okamura, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhisa Ohgi, Shimpei Otsuka, Sumiko Ohnami, Takeshi Nagashima, Keiichi Hatakeyama, Takashi Sugino, Kenichi Urakami, Yasuto Akiyama…
    Citation: BMC Cancer 2022 22:1046
  39. Prediction of patient survival from tumor molecular ‘-omics’ data is a key step toward personalized medicine. Cox models performed on RNA profiling datasets are popular for clinical outcome predictions. But th...

    Authors: Rémy Jardillier, Dzenis Koca, Florent Chatelain and Laurent Guyon
    Citation: BMC Cancer 2022 22:1045
  40. Pancreatic adenocarcinoma (PAAD) is a leading cause of cancer-related mortality in adults. Syndecan-4 (SDC4) is involved in cancer pathogenesis. Therefore, this study aimed to explore the expression and clinic...

    Authors: Yufei Zhu, Dijie Zheng, Linhan Lei, Kun Cai, Huahua Xie, Jian Zheng and Chao Yu
    Citation: BMC Cancer 2022 22:1042
  41. Adjuvant therapies such as radiation therapy, chemotherapy, and immunotherapy are usually given after cancer surgery to improve the survival of cancer patients. However, despite advances in several adjuvant th...

    Authors: Hye Won Kwak, So-Hee Hong, Hyo-Jung Park, Hyeong-Jun Park, Yoo-Jin Bang, Jae-Yong Kim, Yu-Sun Lee, Seo-Hyeon Bae, Hyunho Yoon and Jae-Hwan Nam
    Citation: BMC Cancer 2022 22:1041
  42. Overexpression of the EVI1 (ecotropic viral integration site 1) oncogene has recently been implicated as a prognostic factor in breast cancer (BC), particularly in triple-negative BC (TNBC). In this study we a...

    Authors: Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh…
    Citation: BMC Cancer 2022 22:1040
  43. The incidence of colorectal cancer (CRC) is considered to be the third-highest malignant tumor among all carcinomas. The alterations in cellular bioenergetics (metabolic reprogramming) are associated with seve...

    Authors: Jiaxin Liu, Yimin Li, Qing Xiao, Yuanyuan Li, Yuqian Peng, Yaqi Gan, Guang Shu, Hanxi Yi and Gang Yin
    Citation: BMC Cancer 2022 22:1038
  44. The global burden of hepatocellular carcinoma (HCC) is increasing, negatively impacting social health and economies. The discovery of novel and valuable biomarkers for the early diagnosis and therapeutic guida...

    Authors: Guozhi Wu, Yuan Yang, Rong Ye, Hanxun Yue, Huiyun Zhang, Taobi Huang, Min Liu, Ya Zheng, Yuping Wang, Yongning Zhou and Qinghong Guo
    Citation: BMC Cancer 2022 22:1036
  45. This study aimed to determine the effectiveness of liquid biopsy in detecting epidermal growth factor receptor (EGFR) mutations at diagnosis, disease progression, and intermediate stages.

    Authors: Hiroaki Fujii, Hideyuki Nagakura, Nobuaki Kobayashi, Sousuke Kubo, Katsushi Tanaka, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Masanori Nishikawa, Kenji Miura, Harumi Koizumi, Yu Ito, Motofumi Tsubakihara, Naoki Miyazawa, Makoto Kudo, Masaharu Shinkai…
    Citation: BMC Cancer 2022 22:1035

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