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  1. Acquired resistance to approved tyrosine kinase inhibitors limits their clinical use in patients with gastrointestinal stromal tumor (GIST). This study investigated the safety, tolerability and efficacy of alp...

    Authors: Maria A. Pantaleo, Michael C. Heinrich, Antoine Italiano, Claudia Valverde, Patrick Schöffski, Giovanni Grignani, Anna K. L. Reyners, Sebastian Bauer, Peter Reichardt, Daniel Stark, Ghimja Berhanu, Ulrike Brandt, Tommaso Stefanelli and Hans Gelderblom
    Citation: BMC Cancer 2022 22:511
  2. Atypical teratoid/rhabdoid tumor (AT/RT) is a malignant pediatric tumor of the central nervous system (CNS) with high recurrence and low survival rates that is often misdiagnosed. MicroRNAs (miRNAs) are involv...

    Authors: Xinke Xu, Hongyao Yuan, Junping Pan, Wei Chen, Cheng Chen, Yang Li and Fangcheng Li
    Citation: BMC Cancer 2022 22:499
  3. Current cancer immunotherapies have made tremendous impacts but generally lack high response rates, especially in ovarian cancer. New therapies are needed to provide increased benefits. One understudied approa...

    Authors: Evan B. Glass, Alyssa A. Hoover, Kennady K. Bullock, Matthew Z. Madden, Bradley I. Reinfeld, Whitney Harris, Dominique Parker, Demetra H. Hufnagel, Marta A. Crispens, Dineo Khabele, W. Kimryn Rathmell, Jeffrey C. Rathmell, Andrew J. Wilson, Todd D. Giorgio and Fiona E. Yull
    Citation: BMC Cancer 2022 22:497
  4. To rethink the clinical significance of standardized uptake values (SUVs) of nasopharyngeal carcinoma (NPC) on 18F-fluorodeoxyglucose (18F-FDG) positron-emission tomography (PET).

    Authors: Xiufang Qiu, Haixia Wu, Ting Xu, Shihan Xie, Ziqing You, Yixin Hu, Yinghong Zheng, Zewei Liang, Chaoxiong Huang, Li Yi, Li Li, Jing Liu, Zhaodong Fei and Chuanben Chen
    Citation: BMC Cancer 2022 22:495
  5. TMPRSS2-ERG gene rearrangement, the most common E26 transformation specific (ETS) gene fusion within prostate cancer, is known to contribute to the pathogenesis of this disease and carries diagnostic annotations ...

    Authors: Vipulkumar Dadhania, Daniel Gonzalez, Mustafa Yousif, Jerome Cheng, Todd M. Morgan, Daniel E. Spratt, Zachery R. Reichert, Rahul Mannan, Xiaoming Wang, Anya Chinnaiyan, Xuhong Cao, Saravana M. Dhanasekaran, Arul M. Chinnaiyan, Liron Pantanowitz and Rohit Mehra
    Citation: BMC Cancer 2022 22:494
  6. Breast cancer (BC) has particular characteristics in young women, with diagnosis at more advanced stages, a poorer prognosis and highly aggressive tumors. In NeoFit, we will use an activity tracker to identify...

    Authors: Lidia Delrieu, Anne-Sophie Hamy, Florence Coussy, Amyn Kassara, Bernard Asselain, Juliana Antero, Paul De Villèle, Elise Dumas, Nicolas Forstmann, Julien Guérin, Judicael Hotton, Christelle Jouannaud, Maud Milder, Armand Leopold, Adrien Sedeaud, Pauline Soibinet…
    Citation: BMC Cancer 2022 22:493
  7. The management of meningiomas is challenging, and the role of postoperative radiotherapy is not standardized.

    Authors: Galina Farina Fischer, Detlef Brügge, Nicolaus Andratschke, Brigitta Gertrud Baumert, Davide Giovanni Bosetti, Francesca Caparrotti, Evelyn Herrmann, Alexandros Papachristofilou, Susanne Rogers, Lucia Schwyzer, Daniel Rudolf Zwahlen, Thomas Hundsberger and Paul Martin Putora
    Citation: BMC Cancer 2022 22:492
  8. High medication literacy is the basis of rational medication application and is essential for the management of severe adverse drug reactions. The objective of the present study was to assess the level of medi...

    Authors: Ruofei Du, Huashan Yang, Huiyue Zhou, Lixia Ma, Mikiyas Amare Getu, Changying Chen and Tao Wang
    Citation: BMC Cancer 2022 22:491
  9. Sonic Hedgehog (SHH) pathway dysregulation is implicated in basal cell carcinoma (BCC) development. To evaluate the possible wider role of SHH gene variants in skin carcinogenesis, we assessed associations of ...

    Authors: Astrid J. Rodriguez-Acevedo, Annika Antonsson, Upekha E. Liyanage, Maria Celia Hughes, Scott Gordon, Jolieke van der Pols and Adele C. Green
    Citation: BMC Cancer 2022 22:490
  10. Pancreatic cancer is one of the most lethal tumors. The aim of this study is to provide an effective therapeutic discovery platform for pancreatic cancer by establishing and characterizing patient-derived orga...

    Authors: Sadanori Watanabe, Akitada Yogo, Tsuguteru Otsubo, Hiroki Umehara, Jun Oishi, Toru Kodo, Toshihiko Masui, Shigeo Takaishi, Hiroshi Seno, Shinji Uemoto and Etsuro Hatano
    Citation: BMC Cancer 2022 22:489
  11. Emerging evidence has identified miR-138 as a tumor suppressor that can suppress the proliferation of various cancers. Meanwhile, the cause of abnormal miR-138 expression in cervical cancer remains uncertain. ...

    Authors: Rui Chen, Qiyu Gan, Shuting Zhao, Dongrui Zhang, Shunli Wang, Lili Yao, Min Yuan and Jingxin Cheng
    Citation: BMC Cancer 2022 22:488
  12. Several studies have demonstrated that right-sided tumors have poorer prognosis than left-sided tumors in patients with unresectable colorectal cancer (CRC). The predictive ability of the tumor sidedness in CR...

    Authors: Shinya Abe, Kazushige Kawai, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Tsuyoshi Ozawa, Yuichiro Yokoyama, Yuzo Nagai, Hiroyuki Anzai, Hirofumi Sonoda, Shinichi Yamauchi, Kenichi Sugihara and Soichiro Ishihara
    Citation: BMC Cancer 2022 22:486
  13. The capacity for invasive tissue biopsies followed by histopathology diagnosis in sub-Saharan Africa is severely limited. Consequently, many cancer patients are diagnosed late and outcomes are poor. Here, we p...

    Authors: Ismail D. Legason, Martin D. Ogwang, Clara Chamba, Elifuraha Mkwizu, Claire El Mouden, Hadija Mwinula, Lulu Chirande, Anna Schuh and Faraja Chiwanga
    Citation: BMC Cancer 2022 22:484
  14. A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse. The year-lo...

    Authors: Linea Natalie Toksvang, Bodil Als-Nielsen, Christopher Bacon, Ruta Bertasiute, Ximo Duarte, Gabriele Escherich, Elín Anna Helgadottir, Inga Rinvoll Johannsdottir, Ólafur G. Jónsson, Piotr Kozlowski, Cecilia Langenskjöld, Kristi Lepik, Riitta Niinimäki, Ulrik Malthe Overgaard, Mari Punab, Riikka Räty…
    Citation: BMC Cancer 2022 22:483
  15. More than 60% of oligo-recurrent prostate cancer (PCa) patients treated with metastasis-directed radiotherapy (MDRT) develop biochemical recurrence within 2 years. This recurrence rate emphasises the need for ...

    Authors: J. Janssen, F. H. E. Staal, C. L. Brouwer, J. A. Langendijk, I. J. de Jong, R. J. A. van Moorselaar, E. Schuit, J. F. Verzijlbergen, R. J. Smeenk and S. Aluwini
    Citation: BMC Cancer 2022 22:482
  16. Acute promyelocytic leukaemia (APL) is a unique subtype of acute myeloid leukaemia (AML) characterized by haematopoietic failure caused by the accumulation of abnormal promyelocytic cells in bone marrow (BM). ...

    Authors: Guiran Wang, Guiling Yan, Kanru Sang, Huijie Yang, Ni Sun, Yuanyuan Bai, Feng Xu, Xiaoqun Zheng and Zhanguo Chen
    Citation: BMC Cancer 2022 22:481
  17. We conducted a Pattern-of-care (POC) study at two premier-most public-funded oncology centers in Morocco to evaluate delays in care continuum and adherence to internationally accepted treatment guidelines of c...

    Authors: Abdellatif Benider, Karima Bendahhou, Catherine Sauvaget, Hind Mrabti, Farida Selmouni, Richard Muwonge, Leila Alaoui, Eric Lucas, Youssef Chami, Loubna Abousselham, Maria Bennani, Hassan Errihani, Rengaswamy Sankaranarayanan, Rachid Bekkali and Partha Basu
    Citation: BMC Cancer 2022 22:479
  18. Mutations and fusions in Fibroblast Growth Factor Receptor 3 (FGFR3) occur in 10–20% of metastatic urothelial carcinomas and confer sensitivity to FGFR inhibitors. However, responses to these agents are often sho...

    Authors: Andrew J. Weickhardt, David K. Lau, Margeaux Hodgson-Garms, Austen Lavis, Laura J. Jenkins, Natalia Vukelic, Paul Ioannidis, Ian Y. Luk and John M. Mariadason
    Citation: BMC Cancer 2022 22:478
  19. Platelet counts varied over time after induction chemotherapy. We aimed to investigate the different trajectories of platelet counts after the first cycle of induction chemotherapy in patients newly diagnosed ...

    Authors: Yazhen Bi, Zhaohui Wang, Saran Feng, Yan Wang, Yang Zhao, Hong Li, Jingyi Yu, Qian Liu, Chuansheng Zhu and Mingzhuo Li
    Citation: BMC Cancer 2022 22:477

    The Correction to this article has been published in BMC Cancer 2022 22:647

  20. Prognostic indicators, treatments, and survival estimates vary by cancer type. Therefore, disease-specific models are needed to estimate patient survival. Our primary aim was to develop models to estimate surv...

    Authors: Ashley B. Anderson, Clare Grazal, Rikard Wedin, Claire Kuo, Yongmei Chen, Bryce R. Christensen, Jennifer Cullen and Jonathan A. Forsberg
    Citation: BMC Cancer 2022 22:476
  21. Social media platforms are increasingly being used by stakeholders to generate, access, and share health-related information and experiences. Lung cancer is the most common cancer, impacting > 2 million patien...

    Authors: Ana Rodrigues, Jyoti Chauhan, Alexandros Sagkriotis, Sathyaraj Aasaithambi and Michele Montrone
    Citation: BMC Cancer 2022 22:475
  22. The Lauren classification of gastric tumors strongly correlates with prognosis. The purpose of this study was to explore the specific molecular mechanism of Lauren classification of gastric cancer and provide ...

    Authors: Yuen Tan, Qingchuan Chen, Siwei Pan, Wen An, Huimian Xu, Yao Xing and Jianjun Zhang
    Citation: BMC Cancer 2022 22:474
  23. Gastric cancer (GC) is the fifth most common cancer and the third cause of cancer deaths globally, with late diagnosis, low survival rate, and poor prognosis. This case-control study aimed to evaluate the expr...

    Authors: Maryam Koopaie, Marjan Ghafourian, Soheila Manifar, Shima Younespour, Mansour Davoudi, Sajad Kolahdooz and Mohammad Shirkhoda
    Citation: BMC Cancer 2022 22:473
  24. Poor cancer prognosis has been observed in patients with pre-existing psychiatric disorders. Therefore, we need better knowledge about the diagnosis of cancer in this patient group. The aim of the study was to...

    Authors: Line Flytkjær Virgilsen, Peter Vedsted, Alina Zalounina Falborg, Anette Fischer Pedersen, Anders Prior and Henry Jensen
    Citation: BMC Cancer 2022 22:472
  25. Scalable, multiple behavior change interventions are needed to address poor diet, inactivity, and excess adiposity among the rising number of cancer survivors. Efficacy-tested diet (RENEW) and exercise (BEAT C...

    Authors: Dori Pekmezi, Kevin Fontaine, Laura Q. Rogers, Maria Pisu, Michelle Y. Martin, Yu-Mei Schoenberger-Godwin, Robert A. Oster, Kelly Kenzik, Nataliya V. Ivankova and Wendy Demark-Wahnefried
    Citation: BMC Cancer 2022 22:471
  26. We aimed to evaluate relationships between clinical outcomes and explanatory variables by network clustering analysis using data from a post marketing surveillance (PMS) study of castration-resistant prostate ...

    Authors: Hirotaka Kazama, Osamu Kawaguchi, Takeshi Seto, Kazuhiro Suzuki, Hideyasu Matsuyama, Nobuaki Matsubara, Yuki Tajima and Taro Fukao
    Citation: BMC Cancer 2022 22:470
  27. The prognosis of patients with lung cancer who demonstrate pleural plaques intraoperatively, which may be associated with exposure to asbestos, is unclear. Here, we compared the clinicopathological characteris...

    Authors: Atsushi Kagimoto, Takeshi Mimura, Atsushi Kamigaichi and Yoshinori Yamashita
    Citation: BMC Cancer 2022 22:469
  28. Research in treatment of non-small cell lung cancer (NSCLC) has shown promising results with stereotactic ablative radiotherapy (SABR) of oligometastatic disease, wherein distant disease may be limited to one ...

    Authors: Inderdeep Dhaliwal, Shayan Kassirian, Michael A. Mitchell, Mehdi Qiabi, Andrew Warner, Alexander V. Louie, Harvey H. Wong, Christine M. McDonald, Jason Rajchgot and David A. Palma
    Citation: BMC Cancer 2022 22:468
  29. Laryngeal cancer represents a common malignancy that originates from the larynx, with unfavorable prognosis. Herein, this study systematically analyzed the immune signatures of laryngeal cancer and to evaluate...

    Authors: Li Ren, Ping Li, Zhouping Li and Quan Chen
    Citation: BMC Cancer 2022 22:465
  30. At Silkeborg Regional Hospital, Denmark, the number of stage IA lung cancer increased after implementation of increased use of CT investigations and a corresponding reduction in chest X-ray. The aim of the pre...

    Authors: Charlotte Hyldgaard, Christian Trolle, Stefan Markus Walbom Harders, Henriette Engberg, Torben Riis Rasmussen and Henrik Møller
    Citation: BMC Cancer 2022 22:464
  31. Long course radiotherapy plus neoadjuvant chemotherapy followed by resection (total mesorectal excision, TME) has accepted widespread recognized in the treatment of locally advanced rectal cancer (LARC). Tisle...

    Authors: Zhengyang Yang, Xiao Zhang, Jie Zhang, Jiale Gao, Zhigang Bai, Wei Deng, Guangyong Chen, Yongbo An, Yishan Liu, Qi Wei, Jiagang Han, Ang Li, Gang Liu, Yi Sun, Dalu Kong, Hongwei Yao…
    Citation: BMC Cancer 2022 22:462
  32. The advantages of prophylactic central lymph node dissection (CLND) for clinically node-negative patients remained a great deal of controversies. Our research was aimed to analyze the relationship between cerv...

    Authors: Zheng Zhang, Xin Zhang, Yifei Yin, Shuangshuang Zhao, Keke Wang, Mengyuan Shang, Baoding Chen and Xincai Wu
    Citation: BMC Cancer 2022 22:461
  33. Whether an oxaliplatin- or cisplatin-based regimen is more optimal for treating elderly patients with advanced gastric cancer, in terms of survival and adverse events remains unclear.

    Authors: Takashi Chinen, Yusuke Sasabuchi, Hiroki Matsui, Hironori Yamaguchi and Hideo Yasunaga
    Citation: BMC Cancer 2022 22:460
  34. To independently assess the impact of mandatory testing using an extended DPYD variant panel (ToxNav®) and consequent dose adjustment of Capecitabine/5-FU on recorded quantitative toxicity, symptoms of depress...

    Authors: Apostolos Tsiachristas, Grant Vallance, Rositsa Koleva-Kolarova, Harriet Taylor, Luke Solomons, Giovanni Rizzo, Catherine Chaytor, Junel Miah, Sarah Wordsworth and A. Bassim Hassan
    Citation: BMC Cancer 2022 22:458
  35. Glioma is one of the main causes of cancer-related mortality worldwide and is associated with high heterogeneity. However, the key players determining the fate of glioma remain obscure. In the present study, w...

    Authors: Jie Zhang, Zhangchao Guo, Qiangli Xie, Chuanhong Zhong, Xiangyu Gao and Qiumei Yang
    Citation: BMC Cancer 2022 22:457
  36. Incidence of cervical cancer has been reduced by organized screening while for vaginal and vulvar cancers no systematic screening has been implemented. All these cancers are associated with human papilloma vir...

    Authors: Kari Hemminki, Anna Kanerva, Asta Försti and Akseli Hemminki
    Citation: BMC Cancer 2022 22:456
  37. The study conducted a multicenter study in China to explore the learning curve of contrast enhanced ultrasound (CEUS) for sentinel lymph nodes (SLNs), the feasibility of using this technique for the localizati...

    Authors: Juan Li, Hui Li, Ling Guan, Yun Lu, Weiwei Zhan, Yijie Dong, Peng Gu, Jian Liu, Wen Cheng, Ziyue Na, Lina Tang, Zhongshi Du, Lichun Yang, Saiping Hai, Chen Yang, Qingqiu Zheng…
    Citation: BMC Cancer 2022 22:455
  38. Syphilis is an infectious disease that is at least discussed to be premalignant. This potential, combined with its general pathological impact, raises the question if syphilis increases mortality in oral cance...

    Authors: Moritz Hertel, Leonie Hagedorn, Andrea Maria Schmidt-Westhausen, Henrik Dommisch, Max Heiland, Robert Preissner and Saskia Preissner
    Citation: BMC Cancer 2022 22:454
  39. Abnormal expression of long non-coding RNAs (lncRNAs) has been shown to be associated with the pathogenesis of cancers, including colorectal cancer (CRC). It has been reported that LINC00022 is highly expresse...

    Authors: Lingling Xu, Hongmei He, Yu Shang, Xiaona Qu and Jinghua Sun
    Citation: BMC Cancer 2022 22:453
  40. Currently the five-year survival of childhood cancer is up to 80% due to improved treatment modalities. However, the majority of childhood cancer survivors develop late effects including infertility. Survivors...

    Authors: M. E. Madeleine van der Perk, Eglė Stukaitė-Ruibienė, Žana Bumbulienė, Goda Elizabeta Vaitkevičienė, Annelies M. E. Bos, Marry M. van den Heuvel-Eibrink and Jelena Rascon
    Citation: BMC Cancer 2022 22:450

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