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  1. Contradictory and limited data are available about the presentation and outcomes of patients with RET-fusion positive metastatic NSCLC as compared to patients without RET fusions. This observational study utilizi...

    Authors: Lisa M. Hess, Yimei Han, Yajun Emily Zhu, Naleen Raj Bhandari and Anthony Sireci

    Citation: BMC Cancer 2021 21:28

    Content type: Research article

    Published on:

  2. Ataxia telangiectasia-mutated (ATM) gene contributes to repair damaged DNA and to regulate cell cycle; therefore, ATM variants seem to increase breast cancer risk; however, the results are controversial. So we...

    Authors: Masoumeh Moslemi, Yousef Moradi, Hojat Dehghanbanadaki, Hamed Afkhami, Mansoor Khaledi, Najmeh Sedighimehr, Javad Fathi and Ehsan Sohrabi

    Citation: BMC Cancer 2021 21:27

    Content type: Research article

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  3. In Mainland China, advance directives (ADs) and end-of-life care for patients with tumours, especially patients with brain tumours who may have lost consciousness or the ability to speak at the early stage of ...

    Authors: Yixin Wang, Yongkang Zhang, Yang Hong, Ping Zeng, Zongtao Hu, Xiuli Xu and Hongzhi Wang

    Citation: BMC Cancer 2021 21:25

    Content type: Research article

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  4. The growth- and plasticity-associated protein-43 (GAP43) is biasedly expressed in indigestive system and nervous system. Recent study has shown that GAP43 is responsible for the development of neuronal growth ...

    Authors: Xi Chen, Hongjin Wu, Jia Feng, Ying Li, Jiao Lv, Weikai Shi, Weiwei Fan, Li Xiao, Danmeng Sun, Mingfeng Jiang and Ming Shi

    Citation: BMC Cancer 2021 21:24

    Content type: Research article

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  5. Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 an...

    Authors: Keisuke Miwa, Eiji Oki, Masanobu Enomoto, Keisuke Ihara, Koji Ando, Fumihiko Fujita, Masahiro Tominaga, Shinichiro Mori, Goro Nakayama, Mototsugu Shimokawa, Hiroshi Saeki, Hideo Baba, Masaki Mori and Yoshito Akagi

    Citation: BMC Cancer 2021 21:23

    Content type: Research article

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  6. An accurate intraoperative prediction of lymph node metastatic risk can help surgeons in choosing precise surgical procedures. We aimed to develop and validate nomograms to intraoperatively predict patterns of...

    Authors: Fei Zhao, Rong-Xin Lu, Jin-Yuan Liu, Jun Fan, Hao-Ran Lin, Xiao-Yu Yang, Shu-Hui You, Qian-Ge Wu, Xue-Yun Qin, Yi Liu, Fu-Xi Zhen, Jin-Hua Luo and Wei Wang

    Citation: BMC Cancer 2021 21:22

    Content type: Research article

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  7. Curing locally advanced gastric cancer through surgery alone is difficult. Adjuvant and neoadjuvant chemotherapy bring potential benefits to more patients with gastric cancer based on several clinical trials. ...

    Authors: Xinxin Wang, Shuo Li, Yihong Sun, Kai Li, Xian Shen, Yingwei Xue, Pin Liang, Guoli Li, Luchuan Chen, Qun Zhao, Guoxin Li, Weihua Fu, Han Liang, Hairong Xin, Jian Suo, Xuedong Fang…

    Citation: BMC Cancer 2021 21:20

    Content type: Study protocol

    Published on:

  8. Immune checkpoint blockades (ICBs) are characterized by a durable clinical response and better tolerability in patients with a variety of advanced solid tumors. However, we not infrequently encounter patients ...

    Authors: Seo Ree Kim, Sang Hoon Chun, Joo Ri Kim, Sang-Yeob Kim, Jun Young Seo, Chan Kwon Jung, Bo-Mi Gil, Jeong-Oh Kim, Yoon Ho Ko, In Sook Woo, Byoung Yong Shim, Sook-Hee Hong and Jin Hyoung Kang

    Citation: BMC Cancer 2021 21:19

    Content type: Research article

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  9. Clear cell renal cell carcinoma is susceptible to ferroptosis, and immunotherapy is recently recommended as a priority for the initial treatment of metastatic clear cell renal carcinoma. Increased ferroptosis ...

    Authors: Yanhua Mou, Jinchun Wu, Yao Zhang, Omar Abdihamid, Chaojun Duan and Bin Li

    Citation: BMC Cancer 2021 21:18

    Content type: Research article

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  10. Sequential inhibition of the vascular endothelial growth factor (VEGF) pathway with sorafenib could be useful for patients with metastatic renal cell carcinoma (RCC). Our aim was to determine the activity and ...

    Authors: Ana Elena Martín-Aguilar, Haidé Núñez-López and Juan C. Ramirez-Sandoval

    Citation: BMC Cancer 2021 21:16

    Content type: Research article

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  11. Autophagy is a highly conserved homeostatic process in the human body that is responsible for the elimination of aggregated proteins and damaged organelles. Several autophagy-related genes (ARGs) contribute to...

    Authors: Lei Wu, Wen Quan, Guojun Yue, Qiong Luo, Dongxu Peng, Ying Pan and Guihai Zhang

    Citation: BMC Cancer 2021 21:15

    Content type: Research article

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  12. Chronic obstructive pulmonary disease (COPD) and lung cancer are associated diseases. COPD is underdiagnosed and thus undertreated, but there is limited data on COPD diagnosis in the setting of lung cancer. We...

    Authors: Sophie Corriveau, Gregory R. Pond, Grace H. Tang and John R. Goffin

    Citation: BMC Cancer 2021 21:14

    Content type: Research article

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  13. Kidney cancer (KC) is associated with cardiovascular regulation disorder and easily leads to cardiovascular and cerebrovascular death (CCD), which is one of the major causes of death in patients with KC, espec...

    Authors: Xiaofei Mo, Mingge Zhou, Hui Yan, Xueqin Chen and Yuetao Wang

    Citation: BMC Cancer 2021 21:13

    Content type: Research article

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  14. We hypothesized that portal vein tumor thrombosis (PVTT) in hepatocellular carcinoma (HCC) increases portal pressure and causes esophageal varices and variceal bleedings. We examined the incidence of high-risk...

    Authors: Jihye Lim, Ha Il Kim, Eunju Kim, Jiyoon Kim, Jihyun An, Seheon Chang, Seon-Ok Kim, Han chu Lee, Yung Sang Lee and Ju Hyun Shim

    Citation: BMC Cancer 2021 21:11

    Content type: Research article

    Published on:

  15. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a heterogenous group of tumors. Findings from the phase III NETTER-1 trial showed that treatment of unresectable/metastatic progressive gastroi...

    Authors: J. Smith-Palmer, O. R. Leeuwenkamp, J. Virk and N. Reed

    Citation: BMC Cancer 2021 21:10

    Content type: Research article

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  16. At intensive care unit (ICU) admission, the issue about prognosis of critically ill cancer patients is of clinical interest, especially after ICU discharge. Our objective was to assess the factors associated w...

    Authors: Hubert Gheerbrant, Jean-François Timsit, Nicolas Terzi, Stéphane Ruckly, Mathieu Laramas, Matteo Giaj Levra, Emmanuelle Jacquet, Loic Falque, Denis Moro-Sibilot and Anne-Claire Toffart

    Citation: BMC Cancer 2021 21:9

    Content type: Research article

    Published on:

  17. Reproducible, high-quality surgery is a key point in the management of cancer patients. Quality indicators for surgical treatment of melanoma has been presented with benchmarks but data on morbidity are still ...

    Authors: Antonella Vecchiato, Simone Mocellin, Paolo Del Fiore, Giulio Tosti, Paolo A. Ascierto, Maria Teresa Corradin, Vincenzo De Giorgi, Giuseppe Giudice, Paola Queirolo, Caterina Ferreli, Marcella Occelli, Monica Giordano, Giusto Trevisan, Luigi Mascheroni, Alessandro Testori, Romina Spina…

    Citation: BMC Cancer 2021 21:8

    Content type: Research article

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  18. The continual reassessment method (CRM) identifies the maximum tolerated dose (MTD) more efficiently and identifies the true MTD more frequently compared to standard methods such as the 3 + 3 method. An initia...

    Authors: G. D. James, S. Symeonides, J. Marshall, J. Young and G. Clack

    Citation: BMC Cancer 2021 21:7

    Content type: Research article

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  19. Hepatocellular carcinoma (HCC) remains the most frequent liver cancer, accounting for approximately 90% of primary liver cancers worldwide. The recurrence-free survival (RFS) of HCC patients is a critical fact...

    Authors: Wenhua Wang, Lingchen Wang, Xinsheng Xie, Yehong Yan, Yue Li and Quqin Lu

    Citation: BMC Cancer 2021 21:6

    Content type: Research article

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  20. Cutaneous adverse drug reactions (CADR) associated with oncology therapy involve 45–100% of patients receiving kinase inhibitors. Such adverse reactions may include skin inflammation, infection, pruritus and d...

    Authors: Nicolas Joly-Tonetti, Thomas Ondet, Mario Monshouwer and Georgios N. Stamatas

    Citation: BMC Cancer 2021 21:5

    Content type: Research article

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  21. Immune checkpoint inhibitors and targeted therapies are approved for adjuvant treatment of patients with resected melanoma; however, they have not been compared in randomized controlled trials (RCTs). We compa...

    Authors: Kabirraaj Toor, Mark R. Middleton, Keith Chan, Adenike Amadi, Andriy Moshyk and Srividya Kotapati

    Citation: BMC Cancer 2021 21:3

    Content type: Research article

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  22. MicroRNA (miR)-200c has been widely reported to be involved in colon cancer progress. However, the mechanisms of miR-200c in regulating tumor metastasis and growth remain to be fully elucidated. This study aim...

    Authors: Jinchun Cong, Jian Gong, Chuanjia Yang, Zhixiu Xia and Hong Zhang

    Citation: BMC Cancer 2021 21:2

    Content type: Research article

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  23. This study examined current physical activity levels and preferences for exercise settings and activities among adult survivors of childhood cancers as a strategy to inform the feasibility and design of such p...

    Authors: Denise Rokitka, Jennifer Heffler, Michael Zevon, Caleb Kitcho, Jennifer Schweitzer, Elisa M. Rodriguez and Martin C. Mahoney

    Citation: BMC Cancer 2021 21:1

    Content type: Research article

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  24. Epithelial splicing regulatory protein 1 (ESRP1) and 2 (ESRP2) regulate alternative splicing events of various pre-mRNAs. Some of these targets play a role in cancer-associated processes, including cytoskeleto...

    Authors: Morton Freytag, Martina Kluth, Elena Bady, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Hans Heinzer, Doris Höflmayer, Sören Weidemann, Ria Uhlig, Hartwig Huland, Markus Graefen, Christian Bernreuther, Corinna Wittmer, Maria Christina Tsourlakis, Sarah Minner, David Dum…

    Citation: BMC Cancer 2020 20:1220

    Content type: Research article

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  25. Studies of epigenomic alterations associated with diseases primarily focus on methylation profiles of promoter regions of genes, but not of other genomic regions. In our past work (Das et al. 2019) on patients...

    Authors: Srija Mukhopadhyay, Sahana Ghosh, Debodipta Das, P. Arun, Bidyut Roy, Nidhan K. Biswas, Arindam Maitra and Partha P. Majumder

    Citation: BMC Cancer 2020 20:1219

    Content type: Research article

    Published on:

  26. Metastases are the leading cause of breast cancer-related deaths. The tumor microenvironment impacts cancer progression and metastatic ability. Fibrillar collagen, a major extracellular matrix component, can b...

    Authors: Danielle E. Desa, Robert L. Strawderman, Wencheng Wu, Robert L. Hill, Marcel Smid, J. W. M. Martens, Bradley M. Turner and Edward B. Brown

    Citation: BMC Cancer 2020 20:1217

    Content type: Research article

    Published on:

  27. The prognosis of advanced oral cancer remains dismal. While multimodal therapy is beneficial, maintaining the quality of life of long-term survivors is important. Therefore, risk-adapted treatment regimens nee...

    Authors: Tomohiro Katagiri, Yoshio Ohyama, Hideo Miyamoto, Yuki Egawa, Toshiaki Moriki and Kazuki Hasegawa

    Citation: BMC Cancer 2020 20:1216

    Content type: Research article

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  28. Iron is required for the proliferation of cancer cells, and its depletion suppresses tumor growth. Eribulin mesylate (eribulin), a non-taxane microtubule inhibitor, disrupts the tumor microenvironment via vasc...

    Authors: Wataru Goto, Shinichiro Kashiwagi, Yuka Asano, Koji Takada, Tamami Morisaki, Katsuyuki Takahashi, Hisakazu Fujita, Masatsune Shibutani, Ryosuke Amano, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2020 20:1215

    Content type: Research article

    Published on:

  29. Glypican-1 is a heparan sulfate proteoglycan that is overexpressed in prostate cancer (PCa), and a variety of solid tumors. Importantly, expression is restricted in normal tissue, making it an ideal tumor targ...

    Authors: Maria E. Lund, Christopher B. Howard, Kristofer J. Thurecht, Douglas H. Campbell, Stephen M. Mahler and Bradley J. Walsh

    Citation: BMC Cancer 2020 20:1214

    Content type: Research article

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  30. Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic propert...

    Authors: Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer and John R. Henley

    Citation: BMC Cancer 2020 20:1213

    Content type: Research article

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  31. Little is known about treatment expectations of patients with spinal metastases undergoing radiotherapy and/or surgery. Assuming that patients with spinal metastases share characteristics with patients who had...

    Authors: R. Gal, D. Oostinga, H. Wessels, J. J. Verlaan, R. Charest-Morin, C. G. Fisher, H. M. Verkooijen and A. L. Versteeg

    Citation: BMC Cancer 2020 20:1212

    Content type: Research article

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  32. Tetraspanin CD82 is a tumor metastasis suppressor that is known to down regulate in various metastatic cancers. However, the exact mechanism by which CD82 prevents cancer metastasis is unclear. This study aims...

    Authors: Pushpaja Dodla, Vanitha Bhoopalan, Sok Kean Khoo, Cindy Miranti and Suganthi Sridhar

    Citation: BMC Cancer 2020 20:1211

    Content type: Research article

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  33. Malignant pleural mesothelioma (MPM) is traditionally characterized by local destructive spread of the pleura and surrounding tissues. Patient outcomes in MPM with distant metastatic dissemination are lacking.

    Authors: Dearbhaile Catherine Collins, Raghav Sundar, Anastasia Constantidinou, David Dolling, Timothy Anthony Yap, Sanjay Popat, Mary E. O’Brien, Udai Banerji, Johann Sebastian de Bono, Juanita Suzanne Lopez, Nina Tunariu and Anna Minchom

    Citation: BMC Cancer 2020 20:1210

    Content type: Research article

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  34. There were scarcely germline variants of familial lung cancer (LC) identified. We conducted an study with whole-exome sequencing of pedigrees with familial lung cancer to analyze the potential genetic suscepti...

    Authors: Huan Lin, Gong Zhang, Xu-chao Zhang, Xin-lei Lian, Wen-zhao Zhong, Jian Su, Shi-liang Chen and Yi-long Wu

    Citation: BMC Cancer 2020 20:1209

    Content type: Research article

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  35. To investigate the clinicopathological characteristics of head and neck small cell carcinoma (H&NSmCC) and identify prognostic factors on the basis of the Surveillance, Epidemiology and End Results (SEER) data...

    Authors: Chen-xi Yu, Feiluore Yibulayin, Lei Feng, Meng Wang, Meng-meng Lu, Yuan Luo, Hui Liu, Zhi-cheng Yang and Alimujiang Wushou

    Citation: BMC Cancer 2020 20:1208

    Content type: Research article

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  36. Glycolysis is a central metabolic pathway for tumor cells. However, the potential roles of glycolysis-related genes in renal cell carcinoma (RCC) have not been investigated.

    Authors: Fangshi Xu, Yibing Guan, Li Xue, Shanlong Huang, Ke Gao, Zhen Yang and Tie Chong

    Citation: BMC Cancer 2020 20:1207

    Content type: Research article

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  37. We aimed to identify whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are more useful predictors after initial intention to treat than at the time of diagnosis.

    Authors: Ju-Yeon Kim, Eun Jung Jung, Jae-Myung Kim, Han Shin Lee, Seung-Jin Kwag, Ji-Ho Park, Taejin Park, Sang-Ho Jeong, Chi-Young Jeong and Young-Tae Ju

    Citation: BMC Cancer 2020 20:1206

    Content type: Research article

    Published on:

  38. Hepatocellular carcinoma (HCC) is a malignancy with high incidence and mortality rates worldwide. Alcohol dehydrogenases (ADHs) are huge family of dehydrogenase enzymes and associated with the prognosis of var...

    Authors: Xiangye Liu, Tingting Li, Delong Kong, Hongjuan You, Fanyun Kong and Renxian Tang

    Citation: BMC Cancer 2020 20:1204

    Content type: Research article

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  39. While circulating tumor cells may serve as minimally invasive cancer markers for bladder cancers, the relationship between primary bladder cancers and circulating tumor cells in terms of somatic mutations is l...

    Authors: Tae-Min Kim, Jin-seon Yoo, Hyong Woo Moon, Kyung Jae Hur, Jin Bong Choi, Sung-Hoo Hong, Ji Youl Lee and U-Syn Ha

    Citation: BMC Cancer 2020 20:1203

    Content type: Research article

    Published on:

  40. Response to modern treatment strategies, which combine cytotoxic compounds with immune stimulatory agents and targeted treatment is highly variable among MCL patients. Thus, providing prognostic and predictive...

    Authors: Lavanya Lokhande, Venera Kuci Emruli, Arne Kolstad, Martin Hutchings, Riikka Räty, Mats Jerkeman and Sara Ek

    Citation: BMC Cancer 2020 20:1202

    Content type: Research article

    Published on:

  41. The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. ...

    Authors: M. V. Sheraton, G. G. Y. Chiew, V. Melnikov, E. Y. Tan, K. Q. Luo, N. Verma and P. M. A. Sloot

    Citation: BMC Cancer 2020 20:1201

    Content type: Research article

    Published on:

  42. The study aimed to propose a modified N stage of esophageal cancer (EC) on the basis of the number of positive lymph node (PLN) and the number of negative lymph node (NLN) simultaneously.

    Authors: Jinling Zhang, Hongyan Li, Liangjian Zhou, Lianling Yu, Fengyuan Che and Xueyuan Heng

    Citation: BMC Cancer 2020 20:1200

    Content type: Research article

    Published on:

  43. To determine if extended chemotherapy improves survival outcomes in patients with platinum-sensitive relapsed epithelial ovarian cancer (EOC) who have residual disease after six cycles of second-line chemother...

    Authors: Se Ik Kim, Woo Yeon Hwang, Maria Lee, Hee Seung Kim, Kidong Kim, Hyun Hoon Chung, Jae Hong No, Jae-Weon Kim, Yong Beom Kim, Noh Hyun Park, Yong-Sang Song and Dong Hoon Suh

    Citation: BMC Cancer 2020 20:1199

    Content type: Research article

    Published on:

  44. The incidence of cutaneous malignant melanoma (CMM) is increasing worldwide. In Sweden, over 4600 cases were diagnosed in 2018. The prognosis after radical surgery varies considerably with tumor stage. In rece...

    Authors: Ylva Naeser, Hildur Helgadottir, Yvonne Brandberg, Johan Hansson, Roger Olofsson Bagge, Nils O. Elander, Christian Ingvar, Karolin Isaksson, Petra Flygare, Cecilia Nilsson, Frida Jakobsson, Olga del Val Munoz, Antonis Valachis, Malin Jansson, Charlotte Sparring, Lars Ohlsson…

    Citation: BMC Cancer 2020 20:1197

    Content type: Study protocol

    Published on:

  45. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Giovanna Schiavone, Samantha Epistolio, Vittoria Martin, Francesca Molinari, Jessica Barizzi, Luca Mazzucchelli, Milo Frattini and Luciano Wannesson

    Citation: BMC Cancer 2020 20:1196

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:1085

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