In France, a Pap test for cervical cancer screening is recommended every three years for all sexually active women aged 25 to 65 years. Modes of contraception (any or no contraception, with or without a visit to ...
Authors: Stéphanie Mignot, Virginie Ringa, Solène Vigoureux, Marie Zins, Henri Panjo, Pierre-Jean Saulnier and Xavier Fritel
Different strains of Newcastle disease virus (NDV) worldwide proved to have tumouricidal activity in several types of cancer cells. However, the possible anti-cancer activity of Malaysian NDV AF2240 strain and...
Authors: Juraimi Raihan, Umar Ahmad, Yoke Keong Yong, Zolkapli Eshak, Fauziah Othman and Aini Ideris
Mean platelet volume (MPV) is a marker of platelet activation. MPV and platelet count (PC) are negatively correlated, and their ratio (MPV/PC) is informative for the diagnosis of malignant tumors. However, the...
Authors: Yang-Yang Wu, Xuan Zhang, Yuan-Yuan Qin, Jin-Qiu Qin and Fa-Quan Lin
In the majority of familial breast cancer (BC) families, the etiology of the disease remains unresolved. To identify missing BC heritability resulting from relatively rare variants (minor allele frequency ≤ 1%...
Authors: Rajendra Bahadur Shahi, Sylvia De Brakeleer, Ben Caljon, Ingrid Pauwels, Maryse Bonduelle, Sofie Joris, Christel Fontaine, Marian Vanhoeij, Sonia Van Dooren, Erik Teugels and Jacques De Grève
The tumour microenvironment is a critical regulator of malignant cancer progression. While endothelial cells have been widely studied in the context of tumour angiogenesis, their role as modulators of cancer c...
Authors: Daniela A. Ferraro, Francesca Patella, Sara Zanivan, Cinzia Donato, Nicola Aceto, Monica Giannotta, Elisabetta Dejana, Maren Diepenbruck, Gerhard Christofori and Martin Buess
Feline injection-site sarcoma (FISS), an aggressive iatrogenic subcutaneous malignancy, is challenging to manage clinically and little is known about the molecular basis of its pathogenesis. Tumor transcriptom...
Authors: Qi Wei, Stephen A. Ramsey, Maureen K. Larson, Noah E. Berlow, Donasian Ochola, Christopher Shiprack, Amita Kashyap, Bernard Séguin, Charles Keller and Christiane V. Löhr
Colorectal cancer (CRC) is the second cause of tumour mortality in Spain and Europe. To date, no studies have been conducted in Spain to evaluate the spatial and temporal distribution of the excess risk of dea...
Authors: J. M. García-Torrecillas, M. C. Olvera-Porcel, M. Ferrer-Márquez, F. Rubio-Gil, M J. Sánchez and M. Rodríguez-Barranco
To evaluate the diagnostic value of MR imaging for the differentiation of lipomas and atypical lipomatous tumors (ALT) in comparison with histology and MDM2 amplification status.
Authors: Carolin Knebel, Jan Neumann, Benedikt J. Schwaiger, Dimitris C. Karampinos, Daniela Pfeiffer, Katja Specht, Ulrich Lenze, Rüdiger von Eisenhart-Rothe, Ernst J. Rummeny, Klaus Woertler and Alexandra S. Gersing
Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involve...
Authors: Rinako Miura, Ako Yokoi, Toshihide Matsumoto, Yasuko Oguri, Miki Hashimura, Masataka Tochimoto, Sabine Kajita and Makoto Saegusa
The transcription factor hypoxia inducible factor (HIF) -1 drives tumor growth and metastasis and is associated with poor prognosis in breast cancer. Ascorbate can moderate HIF-1 activity in vitro and is assoc...
Authors: Elizabeth J. Campbell, Gabi U. Dachs, Helen R. Morrin, Valerie C. Davey, Bridget A. Robinson and Margreet C. M. Vissers
Neoadjuvant chemotherapy (NAC) is increasingly used to treat locally advanced breast cancer (LABC). Improved response to NAC correlates with better survival outcomes. The dual purpose of this study is to repor...
Authors: Jonathan Klein, William Tran, Elyse Watkins, Danny Vesprini, Frances C. Wright, Nicole J. Look Hong, Sonal Ghandi, Alex Kiss and Gregory J. Czarnota
In stage III non-small cell lung cancer (NSCLC) treated with concomitant chemoradiotherapy, there is a high rate of relapse. Some of these relapses are only local and can be treated by stereotactic ablative ra...
Authors: Shakeel Sumodhee, Pierre-Yves Bondiau, Michel Poudenx, Charlotte Cohen, Arash O. Naghavi, Bernard Padovani, Daniel Maneval, Jocelyn Gal, Axel Leysalle, Hannah Ghalloussi, Josiane Otto and Jérôme Doyen
Adjuvant therapy improves the prognosis of stage II & III colon cancer patients. Unfortunately, most patients do not benefit from this treatment. PePITA (NCT00994864) is a prospective, multicenter, non-randomi...
Authors: Françoise Rothé, Marion Maetens, Ghizlane Rouas, Marianne Paesmans, Marc Van den Eynde, Jean-Luc Van Laethem, Philippe Vergauwe, Guido Deboever, Yacine Bareche, Caroline Vandeputte, Michail Ignatiadis and Alain Hendlisz
Many factors influence bone metastases of lung cancer, and several studies report about survival of skeletal metastasis. However, few studies have focused on identifying the prognostic factors for skeletal met...
Authors: Yong Jin Cho, Yung Min Cho, Sung Hyun Kim, Kyoo-Ho Shin, Sung-Taek Jung and Hyo Song Kim
Upregulation of SLC2A genes that encode glucose transporter (GLUT) protein is associated with poor prognosis in many cancers. In colorectal cancer, studies reporting the association between overexpression of GLUT...
Authors: Eunyoung Kim, Sohee Jung, Won Seo Park, Joon-Hyop Lee, Rumi Shin, Seung Chul Heo, Eun Kyung Choe, Jae Hyun Lee, Kwangsoo Kim and Young Jun Chai
Genetic alterations, including mutation of epidermal growth factor receptor or v-Ki-ras2 kirsten rat sarcoma viral oncogene homolog and fusion of anaplastic lymphoma kinase (ALK), RET proto-oncogene (RET), or v-r...
Authors: Koh Furugaki, Marie Mochizuki, Mirei Kohno, Sei Shu, Naoki Harada and Yasushi Yoshimura
Solid tumours are less oxygenated than normal tissues. This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. The molecular mechanisms underlying such resistance have been inve...
Authors: Sophie Cowman, Yuen Ngan Fan, Barry Pizer and Violaine Sée
Most tumor cells show aberrantly activated Akt which leads to increased cell survival and resistance to cancer radiotherapy. Therefore, targeting Akt can be a promising strategy for radiosensitization. Here, w...
Authors: Cholpon S. Djuzenova, Vanessa Fiedler, Simon Memmel, Astrid Katzer, Dmitri Sisario, Philippa K. Brosch, Alexander Göhrung, Svenja Frister, Heiko Zimmermann, Michael Flentje and Vladimir L. Sukhorukov
We reported previously the usefulness of 18F-2-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) to predict prognosis of renal cell carcinoma (RCC) treated with molecular targ...
Papillary thyroid cancer (PTC) is the most frequent type of thyroid malignancy. In this study, we investigated the mechanisms whereby long non-coding RNAs (lncRNAs) are associated with PTC pathogenesis.
Authors: Bin Song, Rurun Li, Zhihua Zuo, Juan Tan, Ling Liu, Dafa Ding, Yibing Lu and Dawei Hou
High-grade serous ovarian cancer is a detrimental disease. Treatment options in patients with a recurrent disease are dependent on BRCA1/2 mutation status since only patients with known BRCA mutation are eligible...
Authors: Andreja Gornjec, Srdjan Novakovic, Vida Stegel, Marko Hocevar, Ziva Pohar Marinsek, Barbara Gazic, Mateja Krajc and Erik Skof
Early gastric cancer is associated with a much better prognosis than advanced disease, and strategies to improve prognosis is strictly dependent on earlier detection and accurate diagnosis. Therefore, a label-...
Thyroid cancer is the most frequent endocrine neoplasia worldwide. Information from Andean countries is scarce. In Ecuador there is no reports available of the epidemiology of this type of cancer. The aim of t...
Authors: Jorge Salazar-Vega, Esteban Ortiz-Prado, Paola Solis-Pazmino, Lenin Gómez-Barreno, Katherine Simbaña-Rivera, Aquiles R. Henriquez-Trujillo, Juan P. Brito, Theofilos Toulkeridis and Marco Coral-Almeida
Lysosomal-associated protein transmembrane-4 beta (LAPTM4B), a novel oncogene, promotes tumorigenesis and may be a potential prognostic biomarker in several cancers. This study was to determine the clinical si...
Triple Negative breast cancer (TNBC) is a poor outcome subgroup of breast cancer defined based on the absence of expression of ERα and PR and HER2 amplification. These hard to treat cancers lack targeted treat...
Authors: Paul B. Mullan, Victoria Bingham, Paula Haddock, Gareth W. Irwin, Elaine Kay, Stephen McQuaid and Niamh E. Buckley
Although sorafenib is the global standard first-line systemic treatment for unresectable hepatocellular carcinoma (HCC), it does not have reliable predictive or prognostic biomarkers. Circulating cell-free DNA...
Authors: Chung Ryul Oh, Sun-Young Kong, Hyeon-Su Im, Hwa Jung Kim, Min Kyeong Kim, Kyong-Ah Yoon, Eun-Hae Cho, Ja-Hyun Jang, Junnam Lee, Jihoon Kang, Sook Ryun Park and Baek-Yeol Ryoo
The treatment paradigm for metastatic hormone-sensitive prostate cancer (mHSPC) patients is evolving. PET/CT now offers improved sensitivity and accuracy in staging. Recent randomized trial data supports escal...
Authors: Neil R. Parikh, Claudia Huiza, Jill S. Patel, Sonny Tsai, Nathisha Kalpage, May Thein, Sage Pitcher, Steve P. Lee, Warren S. Inouye, Mark L. Jordan, Homayoon Sanati, Lida Jafari, Carol J. Bennett, Greg E. Gin, Amar U. Kishan, Robert E. Reiter…
Human papillomavirus (HPV) vaccines are indicated for the prevention of cancers and genital warts caused by vaccine-covered HPV types. Although the standard regimen requires a two or three-dose vaccine series,...
Authors: Yi Zeng, Anna-Barbara Moscicki, Vikrant V. Sahasrabuddhe, Francisco Garcia, Heide Woo, Chiu-Hsieh Hsu, Eva Szabo, Eileen Dimond, Susan Vanzzini, Angelica Mondragon, Valerie Butler, Hillary DeRose and H.-H. Sherry Chow
This study aimed to identify potential predictive factors for the survival of advanced non small-cell lung cancer (NSCLC) patients undergoing first-line platinum-based chemotherapy.
Authors: Jun Ying, Danfei Zhou, Tongjie Gu, Jianda Huang and Haijian Liu
Primary central nervous system lymphoma (PCNSL) is a diffuse large B-cell lymphoma (DLBCL) confined to the central nervous system (CNS) with rising incidence among patients > 65 years. Although elderly patient...
Authors: Elisabeth Schorb, Juergen Finke, Gabriele Ihorst, Benjamin Kasenda, Heidi Fricker and Gerald Illerhaus
Recently, the concept of “late presentation with viral hepatitis” was introduced to help quantify the proportion of patients missing timely diagnosis and treatment for viral hepatitis. The clinical implication...
Authors: Dong Hyun Sinn, Danbee Kang, Minwoong Kang, Seung Woon Paik, Eliseo Guallar, Juhee Cho and Geum-Youn Gwak
Venous thromboembolism (VTE) is a common problem in cancer patients and the incidence is increasing, especially for patients with lung cancer. Common features of these patients, like advanced stage, male gende...
Authors: Yungu Chen, Yiu Sing Tsang, Xiaoxia Chou, Jiong Hu and Qing Xia
The tumor microenvironment has a critical role in regulating cancer cell behavior. Tumors with high stromal content are associated with poor patient outcome. The tumor-stroma ratio (TSR) identifies colorectal ...
Authors: Tessa P. Sandberg, Maaike P. M. E. Stuart, Jan Oosting, Rob A. E. M. Tollenaar, Cornelis F. M. Sier and Wilma E. Mesker
Platinum/fluoropyrimidine regimens are the backbone of first-line chemotherapy for advanced gastric cancer (AGC). However response rates to first line chemotherapy range from 30 to 50% and disease progression ...
Authors: Maria Di Bartolomeo, Monica Niger, Federica Morano, Salvatore Corallo, Maria Antista, Stefano Tamberi, Sara Lonardi, Samantha Di Donato, Rossana Berardi, Mario Scartozzi, Giovanni Gerardo Cardellino, Francesco Di Costanzo, Lorenza Rimassa, Alberto Gianluigi Luporini, Raffaella Longarini, Alberto Zaniboni…
Hypopharyngeal and laryngeal neoplasms are both fatal and hard to catch in early stages. Yet which treatment is the most efficacious one still remain unanswered. This network meta-analysis (NMA) was conducted ...
Authors: Juan Che, Yanlin Wang, Xiaolin Zhang and Jun Chen
The survival of OSCC patient needs to be further improved. miR-211 is oncogenic in OSCC and its upregulation is associated with tumor progression and poor patient survival. K14-EGFP-miR-211 transgenic mice also e...
Authors: Yi-Fen Chen, Chung-Ji Liu, Li-Han Lin, Chung-Hsien Chou, Li-Yin Yeh, Shu-Chun Lin and Kuo-Wei Chang
A first-line biologic treatment for metastatic colorectal cancer (mCRC) is still controversial. We, therefore, performed a meta-analysis to determine the efficacy of first-line cetuximab versus bevacizumab for...
Authors: Bobo Zheng, Xin Wang, Mingtian Wei, Quan Wang, Jiang Li, Liang Bi, Xiangbing Deng and Ziqiang Wang
With poor prognosis and limited treatment options for advanced hepatocellular carcinoma (HCC), development of novel therapeutic agents is urgently needed. This single-arm phase I study sought to assess the saf...
Authors: Ying Fan, Shu Li, Xiaoyan Ding, Jian Yue, Jun Jiang, Hong Zhao, Rui Hao, Weiliang Qiu, Kezhen Liu, Ying Li, Shengdian Wang, Limin Zheng, Bin Ye, Kun Meng and Binghe Xu
Codrituzumab, a humanized monoclonal antibody against Glypican-3 (GPC3), which is expressed in hepatocellular carcinoma (HCC), was tested in a randomized phase II trial in advanced HCC patients who had failed ...
Authors: Melanie F. Pradier, Bernhard Reis, Lori Jukofsky, Francesca Milletti, Toshihiko Ohtomo, Fernando Perez-Cruz and Oscar Puig
In clinical oncology, only a few applications have been developed using HPV as a personalized tumor marker, a lack most probably related to the limited information obtained by the classical Polymerase Chain Re...
Authors: Alexandre Harlé, Julie Guillet, Jacques Thomas, Jessica Demange, Gilles Dolivet, Didier Peiffert, Agnès Leroux and Xavier Sastre-Garau
The efficacy of bevacizumab combined with erlotinib (B + E) for the treatment of advanced hepatocellular carcinoma, especially for sorafenib-refractory patients, has been observed and evaluated in several tria...
Authors: Liyun He, Huan Deng, Jun Lei, Fengming Yi, Jine Li, Xiu De Fan, Yiping Wei, Jianjun Xu and Wenxiong Zhang
Hepatocellular carcinoma (HCC) accounts for 75–85% of primary liver cancers and is prevalent in the Asia-Pacific region. Till now, trans-arterial chemoembolization (TACE) is still one of common modalities in m...
There is limited information on changes over time in carcinoid syndrome (CS) symptoms and quality of life (QoL). This study assessed change in CS symptoms and QoL in patients treated with somatostatin analogs ...
Authors: Daniel M. Halperin, Lynn Huynh, Jennifer L. Beaumont, Beilei Cai, Rachel H. Bhak, Sahil Narkhede, Todor Totev, Mei S. Duh, Maureen P. Neary and David Cella
Programmed cell death receptor 1 ligand 1 (PD-L1) expression in various tumors, including hematologic malignancies, has recently become a research topic of great interest. We performed a meta-analysis to evalu...
Authors: Liping Qiu, Hanlu Zheng and Xiaoying Zhao
Physical activity (PA) is a safe and effective strategy to help mitigate health challenges associated with breast cancer (BC) survivorship. However, the majority of BC survivors are not meeting the minimum rec...
Authors: Cristina M. Caperchione, Catherine M. Sabiston, Sean Stolp, Joan L. Bottorff, Kristin L. Campbell, Neil D. Eves, Susan L. Ellard, Carolyn Gotay, Paul Sharp, Tanya Pullen and Kayla M. Fitzpatrick
Atypical squamous cell of undetermined significance (ASCUS) is a common cervical cytological diagnosis. At present, HPV DNA assay is used to triage these patients, but its lower specificity brings a series of ...
Authors: Yuanhang Zhu, Chenchen Ren, Li Yang, Xiaoan Zhang, Ling Liu and Zhaoxin Wang
Cardiovascular medications may be associated with cancer development, but little is known about their association with cancer recurrence. Medications such as statins and antihypertensives may be commonly used ...
Authors: Erin J. A. Bowles, Onchee Yu, Rebecca Ziebell, Lu Chen, Denise M. Boudreau, Debra P. Ritzwoller, Rebecca A. Hubbard, Jennifer M. Boggs, Andrea N. Burnett-Hartman, Andrew Sterrett, Monica Fujii and Jessica Chubak
