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  1. Content type: Research article

    The mTOR/S6K1 signaling pathway is often activated in cervical cancer, and thus considered a molecular target for cervical cancer therapies. Inhibiting mTOR is cytotoxic to cervical cancer cells and creates a ...

    Authors: Ki Hong Nam, Sang Ah Yi, Gibeom Nam, Jae Sung Noh, Jong Woo Park, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Kang Ro Lee, Hyun-Ju Park, Jaecheol Lee and Jeung-Whan Han

    Citation: BMC Cancer 2019 19:773

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  2. Content type: Research article

    Multiple primary melanomas (MPM) occur up to 8% of patients with cutaneous malignant melanoma (CMM). They are often sporadic harbouring several somatic mutations, but also familial cases harbouring a CDKN2A germl...

    Authors: Milena Casula, Panagiotis Paliogiannis, Fabrizio Ayala, Vincenzo De Giorgi, Ignazio Stanganelli, Mario Mandalà, Maria Colombino, Antonella Manca, Maria Cristina Sini, Corrado Caracò, Paolo Antonio Ascierto, Rosanna Rita Satta, Amelia Lissia, Antonio Cossu and Giuseppe Palmieri

    Citation: BMC Cancer 2019 19:772

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  3. Content type: Research article

    Long non-coding RNAs (lncRNAs) represent a substantial portion of the human transcriptome. LncRNAs present a very stringent cell-type/tissue specificity being potential candidates for therapeutical application...

    Authors: Carla Pereira Gomes, Sandrina Nóbrega-Pereira, Beatriz Domingues-Silva, Kenny Rebelo, Catarina Alves-Vale, Sérgio Pires Marinho, Tânia Carvalho, Sérgio Dias and Bruno Bernardes de Jesus

    Citation: BMC Cancer 2019 19:771

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  4. Content type: Research article

    Etoposide (E) at 100 mg/m2 combined with Cisplatin (P) at 20 mg/m2 represents an induction 2-day regimen embedded in our clinical practice for patients with advanced GCT or TN at high risk of early death. We eval...

    Authors: Charleen Chan Wah Hak, Christopher Coyle, Arwa Kocache, Dee Short, Naveed Sarwar, Michael J. Seckl and Michael A. Gonzalez

    Citation: BMC Cancer 2019 19:770

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  5. Content type: Case report

    ROS1 rearrangements are validated drivers in lung cancer, which have been identified in a small subset (1–2%) of patients with non-small cell lung cancer (NSCLC). To date, 18 fusion genes of ROS1 have been identi...

    Authors: Shuguang Xu, Wenxian Wang, Chunwei Xu, Xingliang Li, Junhui Ye, Youcai Zhu and Ting Ge

    Citation: BMC Cancer 2019 19:769

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  6. Content type: Research article

    Human papillomavirus is recognized as a major cause of cervical cancer. It is estimated that annually, 7,095 women are diagnosed with cervical cancer and 4,732 die from the disease in Ethiopia. Understanding that...

    Authors: Kirubel Eshetu Ali, Ibrahim Ali Mohammed, Mesfin Nigussie Difabachew, Dawit Solomon Demeke, Tasew Haile, Robert-Jan ten Hove, Tsegaye Hailu Kumssa, Zufan Lakew Woldu, Eshetu Lemma Haile and Kassu Desta Tullu

    Citation: BMC Cancer 2019 19:768

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  7. Content type: Research article

    Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analys...

    Authors: Jiarui Xiao, Yizi Jin, Ji Nie, Fukun Chen and Xuelei Ma

    Citation: BMC Cancer 2019 19:767

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  8. Content type: Research article

    To describe the patterns of second-line treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) after docetaxel treatment in a Spanish population, to identify the factors associated ...

    Authors: Javier Puente, Aranzazu González-del-Alba, Núria Sala-Gonzalez, María José Méndez-Vidal, Alvaro Pinto, Ángel Rodríguez, José Miguel Cuevas Sanz, Jacobo Rodrigo Muñoz del Toro, Eduardo Useros Rodríguez, Ángela García García-Porrero and Sergio Vázquez

    Citation: BMC Cancer 2019 19:766

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  9. Content type: Study protocol

    Worldwide, over 500,000 people are diagnosed with head and neck cancer each year, a disease with major impact on life expectancy and quality of life. The purpose of the Netherlands Quality of life and Biomedic...

    Authors: I.M. Verdonck-de Leeuw, F. Jansen, R. H. Brakenhoff, J. A. Langendijk, R. Takes, C. H. J. Terhaard, R. J. Baatenburg de Jong, J. H. Smit and C. R. Leemans

    Citation: BMC Cancer 2019 19:765

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  10. Content type: Research article

    MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers. A plethora of drugs wer...

    Authors: Ning Wang, Yanhua Fan, Chun-Mao Yuan, Jialei Song, Yao Yao, Wuling Liu, Babu Gajendran, Eldad Zacksenhaus, Yanmei Li, Jielin Liu, Xiao Jiang Hao and Yaacov Ben-David

    Citation: BMC Cancer 2019 19:764

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  11. Content type: Case report

    Bladder leiomyosarcoma is the most frequent mesenchymal neoplasm of the bladder. However, the rarity of the disease and some morphological aspects could give serious problems to differential diagnosis.

    Authors: Vincenzo Fiorentino, Francesco Pierconti, Niccolò Lenci, Martina Calicchia, Giuseppe Palermo, Pierfrancesco Bassi, Luigi Maria Larocca and Maurizio Martini

    Citation: BMC Cancer 2019 19:763

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  12. Content type: Case report

    Acquired immunodeficiency associated with thymoma is a rare disorder. Here we reported a case of acquired immunodeficiency with thymoma, with an unusual pattern of low CD4+ count with normal gammaglobulin levels.

    Authors: Takahisa Kawamura, Tateaki Naito, Haruki Kobayashi, Kazuhisa Nakashima, Shota Omori, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo and Toshiaki Takahashi

    Citation: BMC Cancer 2019 19:762

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  13. Content type: Research article

    The role of sphere-forming culture in enriching subpopulations with stem-cell properties in hepatocellular carcinoma (HCC) is unclear. The present study investigates its value in enriching cancer stem cells (C...

    Authors: Xiao-Lu Ma, Yun-Fan Sun, Bei-Li Wang, Min-Na Shen, Yan Zhou, Jian-Wen Chen, Bo Hu, Zi-Jun Gong, Xin Zhang, Ya Cao, Bai-shen Pan, Jian Zhou, Jia Fan, Wei Guo and Xin-Rong Yang

    Citation: BMC Cancer 2019 19:760

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  14. Content type: Research article

    Efficacy of treatments for colorectal liver metastases after failure of first-line chemotherapy is limited. The aim of this study was to prospectively evaluate the feasibility, tolerability, and pharmacokineti...

    Authors: Toshihiro Tanaka, Takeshi Sato, Hideyuki Nishiofuku, Tetsuya Masada, Shota Tatsumoto, Nagaaki Marugami, Toshio Otsuji, Masatoshi Kanno, Fumikazu Koyama, Masayuki Sho and Kimihiko Kichikawa

    Citation: BMC Cancer 2019 19:758

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  15. Content type: Research article

    Doxorubicin is currently the most effective chemotherapeutic drug used to treat breast cancer. It has, however, been shown that doxorubicin can induce drug resistance resulting in poor patient prognosis and su...

    Authors: Claudia Christowitz, Tanja Davis, Ashwin Isaacs, Gustav van Niekerk, Suzel Hattingh and Anna-Mart Engelbrecht

    Citation: BMC Cancer 2019 19:757

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  16. Content type: Research article

    Glioblastoma multiforme (GBM) is the most severe type of primary brain tumor with a high mortality rate. Although extensive treatments for GBM, including resection, irradiation, chemotherapy and immunotherapy,...

    Authors: Jui-Chieh Chen, I-Neng Lee, Cheng Huang, Yu-Ping Wu, Chiu-Yen Chung, Ming-Hsueh Lee, Martin Hsiu-Chu Lin and Jen-Tsung Yang

    Citation: BMC Cancer 2019 19:756

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  17. Content type: Research article

    For brain metastases from non-specific primary tumors, the most frequently used and validated clinical prognostic assessment tool is Karnofsky performance status (KPS). Given the lack of prognostic factors of ...

    Authors: Jun Imaizumi, Dai Shida, Yoshitaka Narita, Yasuji Miyakita, Taro Tanabe, Atsuo Takashima, Narikazu Boku, Hiroshi Igaki, Jun Itami and Yukihide Kanemitsu

    Citation: BMC Cancer 2019 19:755

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  18. Content type: Research article

    This study explored the attitudes of patients with advanced cancer towards MTP and return of results, prior to undergoing genomic testing within a research program.

    Authors: Megan C. Best, Nicole Bartley, Chris Jacobs, Ilona Juraskova, David Goldstein, Ainsley J. Newson, Jacqueline Savard, Bettina Meiser, Mandy Ballinger, Christine Napier, David Thomas, Barbara Biesecker and Phyllis Butow

    Citation: BMC Cancer 2019 19:753

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  19. Content type: Research article

    Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are the most lethal mammary cancers. An exacerbated angiogenesis and the existence of vasculogenic mimicry (VM) are hallmarks...

    Authors: Lucía Barreno, Sara Cáceres, Ángela Alonso-Diez, Ana Vicente-Montaña, María Luisa García, Mónica Clemente, Juan Carlos Illera and Laura Peña

    Citation: BMC Cancer 2019 19:750

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  20. Content type: Research article

    Evidence is emerging that older women may tolerate breast cancer therapies equally well as the young ones, providing that they receive good supportive care. It has also been reported that these patients remain...

    Authors: Janusz Kocik, Małgorzata Pajączek and Tomasz Kryczka

    Citation: BMC Cancer 2019 19:749

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  21. Content type: Case report

    Primary retroperitoneal serous adenocarcinoma (PRSA) is an extremely uncommon malignancy exclusively reported in females. Due to the rarity of the disease, it is difficult to establish a standardized treatment.

    Authors: Young Kwang Chae, Naira Saleem, Yoonhwan Roh, Haris Bilal, Pedro Viveiros, Bhoomika Sukhadia, Xiaoqi Lin, Muhammad Mubbashir Sheikh and Lee Chun Park

    Citation: BMC Cancer 2019 19:748

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  22. Content type: Research article

    Phospholipase Cγ1 (PLCγ1) is highly expressed in human tumours. Our previous studies reported that both stable and inducible PLCγ1 down-regulation can inhibit formation of breast-cancer-derived experimental lu...

    Authors: Rossano Lattanzio, Manuela Iezzi, Gianluca Sala, Nicola Tinari, Marco Falasca, Saverio Alberti, Simonetta Buglioni, Marcella Mottolese, Letizia Perracchio, Pier Giorgio Natali and Mauro Piantelli

    Citation: BMC Cancer 2019 19:747

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  23. Content type: Research article

    Expression of human chorionic gonadotropin beta subunit by cancers is extensively documented, yet regulation of the multiple genes that can code for this protein is poorly understood. The aim of the study was ...

    Authors: Aleksandra Śliwa, Marta Kubiczak, Anna Szczerba, Grzegorz Walkowiak, Ewa Nowak-Markwitz, Beata Burczyńska, Stephen Butler, Ray Iles, Piotr Białas and Anna Jankowska

    Citation: BMC Cancer 2019 19:746

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  24. Content type: Research article

    Estrogen receptor β (ERβ) has been repeatedly suggested to play important roles in hormone-dependent cancer like in tumors of the breast, ovary or prostate. In this study, we intended to further elucidate its ...

    Authors: Oliver Treeck, Elisabeth Diepolder, Maciej Skrzypczak, Susanne Schüler-Toprak and Olaf Ortmann

    Citation: BMC Cancer 2019 19:745

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  25. Content type: Research article

    Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with...

    Authors: Philip Savage, David Monk, Jose R. Hernandez Mora, Nick van der Westhuizen, Jennifer Rauw, Anna Tinker, Wendy Robinson, Qianqian Song, Michael J. Seckl and Rosemary A. Fisher

    Citation: BMC Cancer 2019 19:744

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  26. Content type: Research article

    Salivary adenoid cystic carcinoma (SACC) can recur after removal of the primary tumor and treatment, where they can keep no clinical symptoms and dormant state for 10–15 years. NR2F1 has been demonstrated to r...

    Authors: Xiao-lei Gao, Min Zheng, Hao-fan Wang, Lu-ling Dai, Xiang-hua Yu, Xiao Yang, Xin Pang, Li Li, Mei Zhang, Sha-sha Wang, Jing-biao Wu, Ya-Jie Tang, Xin-hua Liang and Ya-ling Tang

    Citation: BMC Cancer 2019 19:743

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  27. Content type: Research article

    There are different contouring guidelines for the clinical target volume (CTV) in anal cancer (AC) which vary concerning recommendations for radiation margins in different anatomical regions, especially on ing...

    Authors: Hendrik Dapper, Kilian Schiller, Stefan Münch, Jan C. Peeken, Kai Borm, Wolfgang Weber and Stephanie E. Combs

    Citation: BMC Cancer 2019 19:742

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  28. Content type: Research article

    The overall prognosis of non-small cell lung cancer (NSCLC) is poor, and currently only patients with localized disease are potentially curable. Therefore, preferably non-invasively determined biomarkers that ...

    Authors: Dijana Djureinovic, Victor Pontén, Per Landelius, Sahar Al Sayegh, Kai Kappert, Masood Kamali-Moghaddam, Patrick Micke and Elisabeth Ståhle

    Citation: BMC Cancer 2019 19:741

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  29. Content type: Research article

    Emerging evidence has shown that miR-1275 plays a critical role in tumour metastasis and the progression of various types of cancer. In this study, we analysed the role and mechanism of miR-1275 in the progres...

    Authors: Jia-Wei Mei, Zi-Yi Yang, Hong-Gang Xiang, Runfa Bao, Yuan-Yuan Ye, Tai Ren, Xue-Feng Wang and Yi-Jun Shu

    Citation: BMC Cancer 2019 19:740

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  30. Content type: Research article

    Genipin is a compound derived from gardenia fruit extract. Although Genipin has anti-tumor effects in various cancers, its effect and mechanism in gastric cancer remain unclear. Here, we investigated the relat...

    Authors: Min Jee Jo, Soyeon Jeong, Hye Kyeong Yun, Dae Yeong Kim, Bo Ram Kim, Jung Lim Kim, Yoo Jin Na, Seong Hye Park, Yoon A. Jeong, Bu Gyeom Kim, Hassan Ashktorab, Duane T. Smoot, Jun Young Heo, Jeongsu Han, Dae-Hee Lee and Sang Cheul Oh

    Citation: BMC Cancer 2019 19:739

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  31. Content type: Research article

    Breast cancer is the most common cancer type in female. As microRNAs play vital role in breast cancer, this study aimed to explore the molecular mechanism and clinical value of miR-21 in breast cancer.

    Authors: Hui Wang, Zheqiong Tan, Hui Hu, Hongzhou Liu, Tangwei Wu, Chao Zheng, Xiuling Wang, Zhenzhao Luo, Jing Wang, Shuiyi Liu, Zhongxin Lu and Jiancheng Tu

    Citation: BMC Cancer 2019 19:738

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  32. Content type: Research article

    Patients with breast cancer undergoing chemotherapy and radiotherapy experience fatigue and other treatment side effects. Integrative therapies combining physical activity and dietary counseling are recommende...

    Authors: Marion Carayol, Gregory Ninot, Pierre Senesse, Jean-Pierre Bleuse, Sophie Gourgou, Hélène Sancho-Garnier, Chakib Sari, Isabelle Romieu, Gilles Romieu and William Jacot

    Citation: BMC Cancer 2019 19:737

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  33. Content type: Research article

    SET domain containing 5 (SETD5) is related to the aggressiveness of prostate and mammary cancers, but its association with non-small cell lung cancer (NSCLC) is unknown. Therefore, the purpose of this research...

    Authors: Hairu Yu, Jiayi Sun, Congxuan Zhao, Haotian Wang, Yeqiu Liu, Jiajia Xiong, Jing Chang, Mixue Wang, Wenhui Wang, Dongman Ye, Hongyan Zhou and Tao Yu

    Citation: BMC Cancer 2019 19:736

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  34. Content type: Research article

    Many older patients don’t receive appropriate oncological treatment. Our aim was to analyse whether there are age differences in the use of adjuvant chemotherapy and preoperative radiotherapy in patients with ...

    Authors: C. Sarasqueta, A. Perales, A. Escobar, M. Baré, M. Redondo, N. Fernández de Larrea, E. Briones, J. M. Piera, M. V. Zunzunegui and J. M. Quintana

    Citation: BMC Cancer 2019 19:735

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  35. Content type: Research article

    Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was to derive a predictive score of advanced colonic neo...

    Authors: Fernando Fernández-Bañares, Ramon Clèries, Jaume Boadas, Josepa Ribes, Joan Carles Oliva, Antoni Alsius, Xavier Sanz, Eva Martínez-Bauer, Sara Galter, Mar Pujals, Marta Pujol, Patricia del Pozo and Rafel Campo

    Citation: BMC Cancer 2019 19:734

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  36. Content type: Research article

    The 8th edition of the tumor-node-metastasis (TNM) classification classifies inguinal lymph nodes as regional lymph nodes for anal canal carcinoma but non-regional lymph nodes for rectal carcinoma. This differ...

    Authors: Taro Tanabe, Dai Shida, Sho Komukai, Yuya Nakamura, Shunsuke Tsukamoto and Yukihide Kanemitsu

    Citation: BMC Cancer 2019 19:733

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  37. Content type: Research article

    Angiopoietin growth factors (Angs) regulate angiogenesis and lymphangiogenesis by binding to the endothelial Tie2 receptor. Ang2 expression is elevated in tissue hypoxia and inflammation, which also induce cle...

    Authors: Leena Tiainen, Emilia A. Korhonen, Veli-Matti Leppänen, Tiina Luukkaala, Mari Hämäläinen, Minna Tanner, Outi Lahdenperä, Pia Vihinen, Arja Jukkola, Peeter Karihtala, Sonja Aho, Eeva Moilanen, Kari Alitalo and Pirkko-Liisa Kellokumpu-Lehtinen

    Citation: BMC Cancer 2019 19:732

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  38. Content type: Research article

    Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). However, whether there is a crosstalk b...

    Authors: Qiang Zhou, Wei Zhang, Zhongfeng Wang and Songyang Liu

    Citation: BMC Cancer 2019 19:731

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  39. Content type: Research article

    Local or distant relapse is the key event for the overall survival of early-stage breast cancer after initial surgery. A small subset of breast cancer cells, which share similar properties with normal stem cel...

    Authors: Yan Qiu, Liya Wang, Xiaorong Zhong, Li Li, Fei Chen, Lin Xiao, Fangyu Liu, Bo Fu, Hong Zheng, Feng Ye and Hong Bu

    Citation: BMC Cancer 2019 19:729

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  40. Content type: Research article

    Breast cancer currently is the most frequently diagnosed neoplasm and the leading cause of death from cancer in women worldwide, which is mainly due to metastatic disease. Increasing our understanding of the m...

    Authors: José Esparza-López, Juan Francisco Alvarado-Muñoz, Elizabeth Escobar-Arriaga, Alfredo Ulloa-Aguirre and María de Jesús Ibarra-Sánchez

    Citation: BMC Cancer 2019 19:728

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  41. Content type: Research article

    Prognostic markers specific to a particular cancer type can assist in the evaluation of survival probability of patients and help clinicians to assess the available treatment modalities.

    Authors: Deepankar Chakroborty, Maheswara Reddy Emani, Riku Klén, Camilla Böckelman, Jaana Hagström, Caj Haglund, Ari Ristimäki, Riitta Lahesmaa and Laura L. Elo

    Citation: BMC Cancer 2019 19:727

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  42. Content type: Study protocol

    The prognosis of patients with metastatic or advanced sarcomas is poor and there are few options for treatment. Several studies have shown that gemcitabine and docetaxel (GD) combination chemotherapy has antit...

    Authors: Hitomi Hara, Teruya Kawamoto, Naomasa Fukase, Yohei Kawakami, Toshiyuki Takemori, Shuichi Fujiwara, Kazumichi Kitayama, Kotaro Nishida, Ryosuke Kuroda and Toshihiro Akisue

    Citation: BMC Cancer 2019 19:725

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