Interaction between cancer cells and fibroblasts mediated by extracellular matrix metalloproteinase inducer (emmprin, CD147) is important in the invasion and proliferation of cancer cells. However, the exact m...
Authors: M. Aoki, K. Koga, M. Miyazaki, M. Hamasaki, N. Koshikawa, M. Oyama, H. Kozuka-Hata, M. Seiki, B. P. Toole and K. Nabeshima
Gliomas account for the majority of primary human brain tumors and remain a challenging neoplasm for cure due to limited therapeutic options. Cell adhesion molecules play pivotal roles in the growth and progre...
Oligosaccharides of glycoprotein, particularly negatively-charged sialylated N-glycans, on the surface of lymphomas play important roles in cell–cell interactions and bind immunoglobulin-like lectins, causing inf...
Older patients with HER2-positive metastatic breast (HER2 + MBC) cancer are underrepresented in clinical trials. We aim to describe the treatment patterns and overall survival (OS) for older women receiving tr...
Authors: Benjamin Daniels, Belinda E. Kiely, Monica Tang, Hanna Tervonen and Sallie-Anne Pearson
This study aimed to evaluate the prognostic value of maximal standard uptake values (SUVmax) of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (PET) comparing with Epstein-Barr virus (EBV) DNA levels i...
Oncoplastic surgery techniques lead to a rearrangement of the breast tissue and impede target definition during adjuvant radiotherapy (RT). The aim of this study was to assess local control rates after immedia...
Authors: Kai Joachim Borm, Christine Schönknecht, Andrea Nestler, Markus Oechsner, Birgit Waschulzik, Stephanie Elisabeth Combs, Stefan Münch, Markus Niemeyer and Marciana Nona Duma
Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial ...
Authors: Marissa B. Savoie, Angela Laffan, Cristina Brickman, Bevin Daniels, Anna Levin, Tami Rowen, James Smith, Erin L. Van Blarigan, Thomas A. Hope, J. Michael Berry-Lawhorn, Mekhail Anwar and Katherine Van Loon
As splenectomy and spleen-preserving lymphadenectomy are performed only in some proximal gastric cancer patients, it is difficult to identify patients who have undergone radical gastrectomy with or without spl...
Authors: Peng Ding, Ziming Gao, Chen Zheng, Junqing Chen, Kai Li and Shan Gao
Appropriate assessment is essential for the management of chemotherapy-induced peripheral neuropathy (CIPN), an intractable symptom that cannot yet be palliated, which is high on the list of causes of distress...
Authors: K. Kanda, K. Fujimoto, R. Mochizuki, K. Ishida and B. Lee
Prostate cancer (PCa) is the second most common cancer among men. New imaging-modalities have increased the diagnosed patients with limited number of metastasis after primary curative therapy, introducing so-c...
Authors: Giulia Marvaso, Delia Ciardo, Giulia Corrao, Sara Gandini, Cristiana Fodor, Dario Zerini, Damaris Patricia Rojas, Matteo Augugliaro, Giuseppina Bonizzi, Salvatore Pece, Federica Cattani, Ketti Mazzocco, Francesco Alessandro Mistretta, Gennaro Musi, Sarah Alessi, Giuseppe Petralia…
The impact of HER2-targeted therapy alone followed by the addition of chemotherapy at disease progression (PD) versus upfront combination was investigated by the SAKK 22/99 trial. The aim of this exploratory a...
Authors: Sabine Schmid, Dirk Klingbiel, Stefan Aebi, Aron Goldhirsch, Christoph Mamot, Elisabetta Munzone, Franco Nolè, Christian Oehlschlegel, Olivia Pagani, Bernhard Pestalozzi, Christoph Rochlitz, Beat Thürlimann, Roger von Moos, Patrik Weder, Khalil Zaman and Thomas Ruhstaller
Poly (ADP-ribose) Polymerase (PARP) inhibitors are promising novel radiosensitisers. Pre-clinical models have demonstrated potent and tumour-specific radiosensitisation by PARP inhibitors. Olaparib is a PARP i...
Authors: R. de Haan, E. van Werkhoven, M.M. van den Heuvel, H. M. U. Peulen, G. S. Sonke, P. Elkhuizen, M. W. M. van den Brekel, M. E. T. Tesselaar, C. Vens, J. H. M. Schellens, B. van Triest and M. Verheij
The sensitivity of endoscopic ultrasound (EUS) in staging gastro-oesophageal cancers (GOCs) has been widely studied. However, the economic evidence of EUS staging in the management of patients with GOCs is sca...
Authors: Seow Tien Yeo, Nathan Bray, Hasan Haboubi, Zoe Hoare and Rhiannon Tudor Edwards
Combination of chemotherapies (fluoropirimidines, oxaliplatin and irinotecan) with biologic drugs (bevacizumab, panitumumab, cetuximab) have improved clinical responses and survival of metastatic colorectal ca...
Authors: Alessandro Ottaiano, Stefania Scala, Nicola Normanno, Maria Napolitano, Monica Capozzi, Anna Maria Rachiglio, Cristin Roma, Anna Maria Trotta, Crescenzo D’Alterio, Luigi Portella, Carmela Romano, Antonino Cassata, Rossana Casaretti, Lucrezia Silvestro, Anna Nappi, Salvatore Tafuto…
Although the leucine zipper-EF-hand-containing transmembrane protein 1 (LETM1) is one of the mitochondrial inner membrane proteins that is involved in cancer prognosis in various tumors, LETM1 as a biomarker f...
Authors: Longzhen Piao, Zhaoting Yang, Ying Feng, Chengye Zhang, Chunai Cui and Yanhua Xuan
We evaluated the clinical efficacy and prognosis of muscle-invasive bladder cancer according to the basal/squamous-like (BASQ) classification system based on immunohistochemical staining [CK5/6(+), CK14(+), GA...
Authors: Hyeong Dong Yuk, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Kyung Chul Moon and Ja Hyeon Ku
Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to...
Authors: Lena Andersch, Josefine Radke, Anika Klaus, Silke Schwiebert, Annika Winkler, Elisa Schumann, Laura Grunewald, Felix Zirngibl, Carina Flemmig, Michael C. Jensen, Claudia Rossig, Antonia Joussen, Anton Henssen, Angelika Eggert, Johannes H. Schulte and Annette Künkele
Heterogeneous ribonucleoproteins (hnRNPs) are involved in the metastasis-related network. Our previous study demonstrated that hnRNP K is associated with epithelial-to-mesenchymal transition (EMT) in A549 cell...
Authors: Liping Li, Songxin Yan, Hua Zhang, Min Zhang, Guofu Huang and Miaojuan Chen
To evaluate the short- and long-term outcomes of 3 different endoscopic dissection techniques for upper gastrointestinal (GI) submucosal tumours (SMTs).
Authors: Xi-Feng Jin, Wei Gai, Rong-Lian Du, Tong-Hai Chai, Ling Li and Christoph J. Auernhammer
Cancer is a leading burden of disease in Australia and worldwide, with incidence rates varying with age, sex and geographic location. As part of the Ageing, Chronic Disease and Injury study, we aimed to map th...
Authors: Stephanie P. Cowdery, Muhammad A. Sajjad, Kara L. Holloway-Kew, Mohammadreza Mohebbi, Lana J. Williams, Mark A. Kotowicz, Patricia M. Livingston, Mustafa Khasraw, Sharon Hakkennes, Trisha L. Dunning, Susan Brumby, Richard S. Page, Alasdair G Sutherland, Sharon L. Brennan-Olsen, Michael Berk, David Campbell…
Glutamate metabotropic receptors (GRM) play a variety of roles in neuronal cells. However, their clinical significance and biological functions in breast cancer remain unknown.
Authors: Bin Xiao, Daxiang Chen, Quan Zhou, Jianfeng Hang, Weiyun Zhang, Zhenzhan Kuang, Zhaohui Sun and Linhai Li
Soft-tissue sarcomas (STS) are rare malignant tumors those are resistant to chemotherapy. We have previously reported the 3-year follow-up result on the efficacy of perioperative chemotherapy with doxorubicin ...
Capacitive-resistive electric transfer (CRET) is a non-invasive therapeutic strategy that applies radiofrequency electric currents within the 400–600 kHz range to tissue repair and regeneration. Previous studi...
Authors: María Luisa Hernández-Bule, Enrique Medel, Clara Colastra, Raquel Roldán and Alejandro Úbeda
Glomus tumors in the digital nerve are extremely rare. Multiple intraneural glomus tumors in different digital nerve fascicles have not been previously reported.
Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic ce...
Authors: Miao Lu, Daniel Hartmann, Rickmer Braren, Aayush Gupta, Baocai Wang, Yang Wang, Carolin Mogler, Zhangjun Cheng, Thomas Wirth, Helmut Friess, Jörg Kleeff, Norbert Hüser and Yoshiaki Sunami
Predicting lung adenocarcinoma (LUAD) risk is crucial in determining further treatment strategies. Molecular biomarkers may improve risk stratification for LUAD.
Authors: Yin Li, Di Ge, Jie Gu, Fengkai Xu, Qiaoliang Zhu and Chunlai Lu
Suffering from cancer confronts both the patient and their partner with a number of psychosocial challenges in various aspects of their life. These challenges may differentially impact on quality of life, copi...
Authors: Inga Lorenz, Daniela Bodschwinna, Nina Hallensleben, Hartmut Döhner, Dietger Niederwieser, Tanja Zimmermann, Anja Mehnert, Harald Gündel, Jochen Ernst and Klaus Hoenig
Population-based studies suggest that emergency department visits and hospitalizations are common among patients receiving chemotherapy and that rates in routine practice are higher than expected from clinical...
Authors: Monika K. Krzyzanowska, Jim A. Julian, Melanie Powis, Doris Howell, Craig C. Earle, Katherine A. Enright, Nicole Mittmann, Maureen E. Trudeau and Eva Grunfeld
Evidences support social inequalities in cancer survival. Studies on hematological malignancies, and more specifically Acute Myeloid Leukemia (AML), are sparser. Our study assessed: 1/ the influence of patient...
Authors: Eloïse Berger, Cyrille Delpierre, Fabien Despas, Sarah Bertoli, Emilie Bérard, Oriane Bombarde, Pierre Bories, Audrey Sarry, Guy Laurent, Christian Récher and Sébastien Lamy
Bispecific T-cell engaging antibodies (BiTES), comprising dual anti-CD3 and anti-tumor antigen scFv fragments, are important therapeutic agents for the treatment of cancer. The dual scFv construct for BiTES re...
Authors: Maciej Kujawski, Lin Li, Supriyo Bhattacharya, Patty Wong, Wen-Hui Lee, Lindsay Williams, Harry Li, Junie Chea, Kofi Poku, Nicole Bowles, Nagarajan Vaidehi, Paul Yazaki and John E. Shively
Gene expression profiling of rare cancers has proven challenging due to limited access to patient materials and requirement of intact, non-degraded RNA for next-generation sequencing. We customized a gene expr...
Authors: Jasmine A. McQuerry, David F. Jenkins, Susan E. Yost, Yuqing Zhang, Daniel Schmolze, W. Evan Johnson, Yuan Yuan and Andrea H. Bild
Abrogation of growth factor-dependent signaling represents an effective therapeutic strategy for patients with colorectal cancer (CRC). Here we evaluated the effectiveness of targeting the epidermal growth fac...
Authors: Lena-Christin Conradi, Melanie Spitzner, Anna-Lena Metzger, Merle Kisly, Peter Middel, Hanibal Bohnenberger, Jochen Gaedcke, Michael B. Ghadimi, Torsten Liersch, Joseph Rüschoff, Tim Beißbarth, Alexander König and Marian Grade
Enterotoxigenic Bacteroides fragilis (ETBF) is an enterotoxin-producing bacterium that possibily has a role in the occurrence and progression of colorectal cancer (CRC) by modulating the mucosal immune response a...
Authors: Fakhri Haghi, Elshan Goli, Bahman Mirzaei and Habib Zeighami
We aimed to develop inhibitory short peptides that can prevent protein interactions of SOS1/EPS8/ABI1 tri-complex, a key component essential for ovarian cancer metastasis.
Breast cancer is the most common malignancy in women, and neoadjuvant chemotherapy has been recommended to the patients with locally advanced breast cancer as the initial treatments. Long non-coding RNA (lncRN...
Authors: Battseren Bayarmaa, Ziping Wu, Jing Peng, Yan Wang, Shuguang Xu, Tingting Yan, Wenjin Yin, Jinsong Lu and Liheng Zhou
Bone metastases represent an important source of morbidity in cancer patients, mostly due to severe pain. Radiotherapy is an established symptomatic treatment for painful bone metastases, however, when convent...
Authors: Carole Mercier, Piet Dirix, Piet Ost, Charlotte Billiet, Ines Joye, Peter Vermeulen, Yolande Lievens and Dirk Verellen
Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignant digestive tumors around the world. We previously demonstrated that eIF3b could promote the progression of ESCC. The exact mechani...
Authors: Fengkai Xu, Shu Zhang, Zhonghe Liu, Jie Gu, Yin Li, Lin Wang, Wei Mao, Qiaoliang Zhu, Huankai Shou, Di Ge and Chunlai Lu
The ubiquitous expressed transcript (UXT) plays a key role in various tumors by regulating transcriptional activity of multiple transcription factors, including androgen receptor (AR). However, the role of UXT...
Authors: Jin Zeng, Wei Xiang, Yucong Zhang, Chunhua Huang, Ke Chen and Zhiqiang Chen
This study investigated a large number of patients to develop a predictive nomogram for survival and a web-based survival rate calculator that can dynamically predict the long-term survival of patients with pr...
Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of p...
Authors: Shinya Otani, Robert Nakayama, Tetsuya Sekita, Toru Hirozane, Naofumi Asano, Kazumasa Nishimoto, Aya Sasaki, Hajime Okita, Hideo Morioka, Masaya Nakamura and Morio Matsumoto
Metastasis of gastric cancer commonly manifests as a malignant effusion, which presents an alternative cell source for human epidermal growth factor receptor 2 (HER2) status identification. This study aimed to...
Authors: Hongsik Kim, Seung-Myoung Son, Chang Gok Woo, Ok-Jun Lee, Dae Hoon Kim, Hyo Yung Yun, Jieun Yun, Hee Kyung Kim, Yaewon Yang and Hye Sook Han
The relationship between first-degree family history of female breast cancer and prostate cancer risk in the general population remains unclear. We performed a meta-analysis to determine the association betwee...
Trauma- and stressor-related disorders pose an important threat for patients with medical conditions by negatively affecting the outcomes of the underlying somatic disease. Nevertheless, research on distress i...
Authors: Peter Esser, Katharina Kuba, Jochen Ernst and Anja Mehnert-Theuerkauf
Few studies compared cancer incidence among migrants both to their host countries and to their population of origin. We aimed to compare cancer incidence of ethnic Germans who migrated from the former Soviet U...
Authors: Philipp Jaehn, Simone Kaucher, Lidia V. Pikalova, Sofia Mazeina, Hiltraud Kajüter, Heiko Becher, Mikhail Valkov and Volker Winkler
Desmoplastic small round cell tumor (DSRCT) is a rare malignancy with poor prognosis that generally involves the peritoneum. Its diagnosis can be achieved only by immunohistochemistry and cytogenetic studies.
Authors: Yanli Tao, Lina Shi, Li Ge, Tiejun Yuan and Li Shi
MiR-221, acting as onco-miR or oncosuppressor-miR, plays an important role in tumor progression; however, the prognostic value of miR-221 in human carcinomas is controversial and inconclusive. The objective of...
Metformin is proven to improve the prognosis of various cancers, but it is unknown if metformin could ameliorate hypopharyngeal cancer in diabetes mellitus patients. This was a retrospective cohort study, and ...
Authors: Yung-An Tsou, Wen-Dien Chang, Jian-Ji Lu, Tsu-Fang Wu, Hsiao-Ling Chen, Chuan-Mu Chen and Ming Hsui Tsai
Our purpose was to examine the outcomes of patients who underwent extensive resection of periacetabular tumors involving the sacroiliac joint and joint reconstruction with a hemipelvic endoprosthesis.
Authors: Bo Wang, Changye Zou, Xiaokun Hu, Jian Tu, Hao Yao, Junqiang Yin, Gang Huang, Xianbiao Xie and Jingnan Shen
We report on our experience of ultrasound (US)-guided dual-localization for axillary nodes before and after neoadjuvant chemotherapy (NAC) with clip and activated charcoal to guide axillary surgery in breast c...
Authors: Won Hwa Kim, Hye Jung Kim, See Hyung Kim, Jin Hyang Jung, Ho Yong Park, Jeeyeon Lee, Wan Wook Kim, Ji Young Park, Yee Soo Chae and Soo Jung Lee
