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  1. Recent studies have shown that chemotherapy destabilizes the blood vasculature and increases circulating tumor cell (CTC) influx into the circulation of metastatic cancer patients (Met-pa). CTCs are a precurso...

    Authors: Nerymar Ortiz-Otero, Jocelyn R. Marshall, Bradley Lash and Michael R. King

    Citation: BMC Cancer 2020 20:873

    Content type: Research article

    Published on:

  2. 5α-reductase inhibitors (5-ARIs) inhibit the pathway of converting the testosterone to dihydrotestosterone and are widely used in benign prostatic hyperplasia patients. Since androgen receptor activation may p...

    Authors: Chien-Sheng Wang, Ching-Chia Li, Yung-Shun Juan, Wen-Jeng Wu and Hsiang-Ying Lee

    Citation: BMC Cancer 2020 20:872

    Content type: Research article

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  3. Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin and sulindac are effective for colorectal cancer prevention in humans and some animal models, but concerns over gastro-intestinal (GI) ulceration ...

    Authors: Jennifer S. Davis, Preeti Kanikarla-Marie, Mihai Gagea, Patrick L. Yu, Dexing Fang, Manu Sebastian, Peiying Yang, Ernest Hawk, Roderick Dashwood, Lenard M. Lichtenberger, David Menter and Scott Kopetz

    Citation: BMC Cancer 2020 20:871

    Content type: Research article

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  4. BRAF-activated noncoding RNA (BANCR) is aberrantly expressed in various tumor tissues and has been confirmed to function as a tumor suppressor or oncogene in many types of cancers. Considering the conflicting ...

    Authors: Shixu Fang, Zhou Liu, Qiang Guo, Cheng Chen, Xixian Ke and Gang Xu

    Citation: BMC Cancer 2020 20:870

    Content type: Research article

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  5. Indoleamine 2, 3-dioxygenase-1 (IDO1) is a promising target for immunotherapy in bladder cancer (BC). IDO1 breaks-down tryptophan to generate kynurenine derivatives, which may activate the aryl hydrocarbon rec...

    Authors: Luiz Henrique Gomes Matheus, Stephanie Vanin Dalmazzo, Rodrigo Barbosa Oliveira Brito, Lucas Alves Pereira, Robson José de Almeida, Cleber Pinto Camacho and Humberto Dellê

    Citation: BMC Cancer 2020 20:869

    Content type: Research article

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  6. The standard chemotherapy regimens for soft tissue sarcoma are doxorubicin-based. This retrospective study aimed to assess the efficacy and safety of pirarubicin, ifosfamide, and etoposide combination therapy ...

    Authors: Shiro Saito, Hisaki Aiba, Satoshi Yamada, Hideki Okamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Takanobu Otsuka and Hideki Murakami

    Citation: BMC Cancer 2020 20:868

    Content type: Research article

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  7. Terminal-stage solid tumors are one of the main causes of disseminated intravascular coagulation (DIC); effective therapeutic strategies are therefore warranted. This study aimed to investigate the association...

    Authors: Kohei Taniguchi, Hiroyuki Ohbe, Kazuma Yamakawa, Hiroki Matsui, Kiyohide Fushimi and Hideo Yasunaga

    Citation: BMC Cancer 2020 20:867

    Content type: Research article

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  8. An increasing number of studies have described the aberrant expression of homeobox (HOX) proteins in gastric cancer (GC), which is critically associated with the prognosis and clinicopathological characteristi...

    Authors: Xiao Jin, Lu Dai, Yilan Ma, Jiayan Wang, Haihao Yan, Ye Jin, Xiaojuan Zhu and Zheng Liu

    Citation: BMC Cancer 2020 20:866

    Content type: Research article

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  11. Melanoma has the highest mortality rate of all skin tumors, and metastases are the major cause of death from it. The molecular mechanism leading to melanoma metastasis is currently unclear.

    Authors: Wenxing Su, Yi Guan, Biao Huang, Juanjuan Wang, Yuqian Wei, Ying Zhao, Qingqing Jiao, Jiang Ji, Daojiang Yu and Longjiang Xu

    Citation: BMC Cancer 2020 20:863

    Content type: Research article

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  12. The aim of this study is to assess biplane transrectal ultrasonography (TRUS) plus ultrasonic elastosonography (UE) and contrast-enhanced ultrasonography (CEUS) in T staging of rectal cancer.

    Authors: Yanru Feng, Chanjuan Peng, Yuan Zhu and Luying Liu

    Citation: BMC Cancer 2020 20:862

    Content type: Research article

    Published on:

  13. Breast Cancer (BC) is associated with inherited gene mutations. High throughput genotyping of BC samples has led to the identification and characterization of biomarkers for the diagnosis of BC. The most commo...

    Authors: Divya Bakshi, Ashna Nagpal, Varun Sharma, Indu Sharma, Ruchi Shah, Bhanu Sharma, Amrita Bhat, Sonali Verma, Gh. Rasool Bhat, Deepak Abrol, Rahul Sharma, Samantha Vaishnavi and Rakesh Kumar

    Citation: BMC Cancer 2020 20:861

    Content type: Research article

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  14. Gastric/gastroesophageal junction (GEJ) adenocarcinomas are heterogeneous, comprising four molecularly distinct subtypes, namely EBV-positive, microsatellite instability (MSI), chromosomal instability (CIN) an...

    Authors: Ju-Yoon Yoon, Christine Brezden-Masley and Catherine J. Streutker

    Citation: BMC Cancer 2020 20:860

    Content type: Research article

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  15. To date, the contribution of BRCA1/2 mutations in Moroccan early onset breast cancer patients remains unknown. Here we assess these genetic alterations for the first time in a cohort from North of Morocco.

    Authors: Joaira Bakkach, Mohamed Mansouri, Touria Derkaoui, Ali Loudiyi, ElMostafa El Fahime, Amina Barakat, Naima Ghailani Nourouti, Jaime Martinez De Villarreal, Carlos Cortijo Bringas and Mohcine Bennani Mechita

    Citation: BMC Cancer 2020 20:859

    Content type: Research article

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  16. Worldwide cervical cancer is the third most common malignancy in women. It usually arises from the cervical area which is susceptible to Human Papilloma virus induced malignancy changes. In low-resource settin...

    Authors: Gebretsadik Hailemariam, Hailay Gebreyesus, Tewolde Wubayehu, Tsgehana Gebregyorgis, Kidanemariam Gebrecherkos, Mebrahtu Teweldemedhin and Manaye Kifle

    Citation: BMC Cancer 2020 20:858

    Content type: Research article

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  17. Endometrial cancer (EC) is the most common gynecologic cancer in women, and the incidence of EC has increased by about 1% per year in the U. S over the last 10 years. Although 5-year survival rates for early-s...

    Authors: Daniel G. Piqué, John M. Greally and Jessica C. Mar

    Citation: BMC Cancer 2020 20:857

    Content type: Research article

    Published on:

  18. Germline copy number variants (CNVs) increase risk for many diseases, yet detection of CNVs and quantifying their contribution to disease risk in large-scale studies is challenging due to biological and techni...

    Authors: Stephen Cristiano, David McKean, Jacob Carey, Paige Bracci, Paul Brennan, Michael Chou, Mengmeng Du, Steven Gallinger, Michael G. Goggins, Manal M. Hassan, Rayjean J. Hung, Robert C. Kurtz, Donghui Li, Lingeng Lu, Rachel Neale, Sara Olson…

    Citation: BMC Cancer 2020 20:856

    Content type: Research article

    Published on:

  19. Endocrine therapy (ET)-based regimens are the mainstay of treatment for patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2−) advanced breast cancer. With the in...

    Authors: Alison Davie, Gebra Cuyun Carter, Alex Rider, James Pike, Katie Lewis, Abigail Bailey, Gregory L. Price, Francois Ringeisen and Xavier Pivot

    Citation: BMC Cancer 2020 20:855

    Content type: Research article

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  21. Excision Repair Cross-Complementation group 6-like (ERCC6L) has been shown to exhibit carcinogenic effect in several malignant tumors. However, the function and molecular mechanism of the ERCC6L in hepatocellu...

    Authors: Han Chen, Hengxiao Wang, Xiqiao Yu, Shuping Zhou, Yueying Zhang, Zhaopeng Wang, Shuhong Huang and Zhaoxia Wang

    Citation: BMC Cancer 2020 20:853

    Content type: Research article

    Published on:

  22. As inadequate pain communication contributes to difficulties in optimizing outcomes of outpatients, we investigated the effect of reinforced education using WeChat App to the opioid titration treatment of canc...

    Authors: Zhiyou Peng, Lin Li, Yuan Chen, Zhiying Feng and Xiangming Fang

    Citation: BMC Cancer 2020 20:852

    Content type: Research article

    Published on:

  23. The risk of positive lymph nodes in patients with muscle-invasive bladder urothelial carcinoma (MIBC) can be used to guide treatment recommendations. However, little is known about the effect of age on lymph n...

    Authors: Zijian Tian, Lingfeng Meng, Xin Wang, Tongxiang Diao, Maolin Hu, Miao Wang, Ming Liu and Jianye Wang

    Citation: BMC Cancer 2020 20:851

    Content type: Research article

    Published on:

  24. There are profound individual differences in clinical outcomes between colorectal cancers (CRCs) presenting with identical stage of disease. Molecular stratification, in conjunction with the traditional TNM st...

    Authors: R. R. J. Coebergh van den Braak, S. ten Hoorn, A. M. Sieuwerts, J. B. Tuynman, M. Smid, S. M. Wilting, J. W. M. Martens, C. J. A. Punt, J. A. Foekens, J. P. Medema, J. N. M. IJzermans and L. Vermeulen

    Citation: BMC Cancer 2020 20:850

    Content type: Research article

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  25. Both the 7th and 8th editions of the American Joint Committee on Cancer (AJCC) staging system for perihilar cholangiocarcinoma (pCCA) had the same definition for T2a and T2b. But the value of this classificati...

    Authors: Jian Zhao, Wei Zhang, Jun Zhang, Yi Zhang, Wen-Jie Ma, Si-Yun Liu, Fu-Yu Li and Bin Song

    Citation: BMC Cancer 2020 20:849

    Content type: Research article

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  26. Screening for early detection of lung cancer has been performed in high-risk individuals with smoking history. However, researches on the distribution, clinical characteristics, and prognosis of these high-ris...

    Authors: Woo Ho Ban, Chang Dong Yeo, Solji Han, Hye Seon Kang, Chan Kwon Park, Ju Sang Kim, Jin Woo Kim, Seung Joon Kim, Sang Haak Lee and Sung Kyoung Kim

    Citation: BMC Cancer 2020 20:848

    Content type: Research article

    Published on:

  27. Oncotype DX® (ODX) is used to assess risk of disease recurrence in hormone receptor positive, HER2-negative breast cancer and to guide decisions regarding adjuvant chemotherapy. Little is known about how physi...

    Authors: Thomas M. Schwedhelm, Judy R. Rees, Tracy Onega, Ronnie J. Zipkin, Andrew Schaefer, Maria O. Celaya and Erika L. Moen

    Citation: BMC Cancer 2020 20:847

    Content type: Research article

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  28. It is essential to have information on the disease burden of lung cancer at an individual level throughout the life; however, few such results have been reported. Thus, this study aimed to assess the lifetime ...

    Authors: Hae-Young Park, Jinseub Hwang, Do-Hyang Kim, Soo Min Jeon, Sun Ha Choi and Jin-Won Kwon

    Citation: BMC Cancer 2020 20:846

    Content type: Research article

    Published on:

  29. Endometrial cancer, one of the most common malignant tumors, is a serious threat to women’s health. Endometrial hyperplasia is a precursor of endometrial cancer. S100 calcium binding protein P (S100P) has been...

    Authors: Dan Zhang, Xiuying Chen, Hexia Xia, Lu Wang, Hongbo Zhao, Bufang Xu, Aijun Zhang and Wei Zhang

    Citation: BMC Cancer 2020 20:845

    Content type: Research article

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  30. We aimed to identify which part of the patients with metastatic renal cell carcinoma (mRCC) is not suitable for cytoreductive nephrectomy (CN).

    Authors: Zhao Zhang, Hongliang Wu, Tong Yang, Yaohai Wu, Nengwang Yu and Zhonghua Xu

    Citation: BMC Cancer 2020 20:844

    Content type: Research article

    Published on:

  31. Cell-in-cell structures (caused by cell cannibalistic activity) have been related to prognosis of many cancers. This is the first multi-institutional study to assess the prognostic impact of cell-in-cell struc...

    Authors: Alhadi Almangush, Antti A. Mäkitie, Jaana Hagström, Caj Haglund, Luiz Paulo Kowalski, Pentti Nieminen, Ricardo D. Coletta, Tuula Salo and Ilmo Leivo

    Citation: BMC Cancer 2020 20:843

    Content type: Research article

    Published on:

  32. Fibrosis surrounding cancer cells has been shown to affect cancer cell metastatic behavior. The present study aimed to explore the utility of myxoid stroma as a predictive factor for postoperative relapse in p...

    Authors: Takashi Okuyama, Shinichi Sameshima, Emiko Takeshita, Takashi Mitsui, Takuji Noro, Yuko Ono, Tamaki Noie, Shinichi Ban and Masatoshi Oya

    Citation: BMC Cancer 2020 20:842

    Content type: Research article

    Published on:

  33. Long noncoding RNAs (lncRNA) play a role in leukemogenesis, maintenance, development, and therapeutic resistance of AML. While few studies have focused on the prognostic significance of LINC00649 in AML, which...

    Authors: Chao Guo, Ya-yue Gao, Qian-qian Ju, Chun-xia Zhang, Ming Gong and Zhen-ling Li

    Citation: BMC Cancer 2020 20:841

    Content type: Research article

    Published on:

  34. Genomic instability is a hallmark of cancer. The G1 checkpoint allows cells to repair damaged DNA that may lead to genomic instability. The high-risk human papillomavirus (HPV) E7 gene can abrogate the G1 chec...

    Authors: Yunying Zhou, Fengyan Pei, Mingyu Ji, Fang Zhang, Yingshuo Sun, Qianqian Zhao, Xiao Wang, Yatian Hong, Juanjuan Tian, Yunshan Wang and Jason J. Chen

    Citation: BMC Cancer 2020 20:840

    Content type: Research article

    Published on:

  36. Breast cancer (BC) is a malignant tumor that occurs in the epithelial tissue of the breast gland. Long non-coding RNA (lncRNA) small nucleolar RNA host gene 3 (SNHG3) has been found to promote BC cell prolifer...

    Authors: Hongnan Jiang, Xiaojun Li, Wei Wang and Honglin Dong

    Citation: BMC Cancer 2020 20:838

    Content type: Research article

    Published on:

  37. In 1997, the Radiation Therapy Oncology Group (RTOG) put forward the recursive partitioning analysis classification for the prognosis of brain metastases (BMs), but this system does not take into account the epid...

    Authors: Jing Wang, Zhiyan Liu, Qingsong Pang, Tian Zhang, Xi Chen, Puchun Er, Yuwen Wang, Ping Wang and Jun Wang

    Citation: BMC Cancer 2020 20:837

    Content type: Research article

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  38. Interaction between microenvironment and breast cancer cells often is not considered at the early stages of drug development leading to failure of many drugs at later clinical stages. Etanercept is a TNF-alpha...

    Authors: Elnaz Shirmohammadi, Seyed-Esmaeil Sadat Ebrahimi, Amir Farshchi and Mona Salimi

    Citation: BMC Cancer 2020 20:836

    Content type: Research article

    Published on:

  39. To investigate the differences in plasma metabolomic characteristics between pathological complete response (pCR) and non-pCR patients and identify biomarker candidates for predicting the response to neoadjuva...

    Authors: Yaowen Zhang, Jianpo Wang, Ningtao Dai, Peng Han, Jian Li, Jiangman Zhao, Weilan Yuan, Jiahuan Zhou and Fuyou Zhou

    Citation: BMC Cancer 2020 20:835

    Content type: Research article

    Published on:

  40. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Khayal Al-Khayal, Mansoor-Ali Vaali-Mohammed, Mohammed Elwatidy, Thamer Bin Traiki, Omar Al-Obeed, Mohammad Azam, Zahid Khan, Maha Abdulla and Rehan Ahmad

    Citation: BMC Cancer 2020 20:834

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:685

  41. Cervical cancer has long been a common malignance troubling women. However, there are few studies developing nomogram with comprehensive factors for the prognosis of cervical cancer. Hence, we aimed to build a...

    Authors: Guilan Xie, Ruiqi Wang, Li Shang, Cuifang Qi, Liren Yang, Liyan Huang, Wenfang Yang and Mei Chun Chung

    Citation: BMC Cancer 2020 20:833

    Content type: Research article

    Published on:

  42. Phase 3 studies suggest that induction chemotherapy (ICT) of cisplatin and 5-fluorouracil plus docetaxel (TPF) is effective but toxic for patients with squamous-cell carcinoma of the head and neck (SCCHN). Dos...

    Authors: Ching-Yun Hsieh, Ming-Yuh Lein, Shih-Neng Yang, Yao-Ching Wang, Yin-Jun Lin, Chen-Yuan Lin, Chun-Hung Hua, Ming-Hsul Tsai and Ching-Chan Lin

    Citation: BMC Cancer 2020 20:832

    Content type: Research article

    Published on:

  43. Current standard practice for locally advanced rectal cancer (LARC) entails a multidisciplinary approach that includes preoperative chemoradiotherapy, followed by total mesorectal excision, and then adjuvant c...

    Authors: Ali Shamseddine, Youssef H. Zeidan, Malek Kreidieh, Ibrahim Khalifeh, Rim Turfa, Joseph Kattan, Deborah Mukherji, Sally Temraz, Kholoud Alqasem, Rula Amarin, Tala Al Awabdeh, Samer Deeba, Faek Jamali, Issa Mohamad, Mousa Elkhaldi, Faiez Daoud…

    Citation: BMC Cancer 2020 20:831

    Content type: Study protocol

    Published on:

  44. Our objective was to assess racial differences in the 5-year relative survival rates (RSRs) of Cervical Cancer (CerCancer) by stage at diagnosis, between Black and White women, living in Alabama, USA.

    Authors: Ehsan Abdalla, Roberta Troy, Souleymane Fall, Isra Elhussin, Oyoyo Egiebor-Aiwan and David Nganwa

    Citation: BMC Cancer 2020 20:830

    Content type: Research article

    Published on:

  45. Tyrosine-kinase inhibitors (TKIs) have become the cornerstone treatment of patients with non-small cell lung cancer that harbor oncogenic EGFR mutations. The counterpart of these drugs is the financial burden ...

    Authors: Oscar Arrieta, Rodrigo Catalán, Silvia Guzmán-Vazquez, Feliciano Barrón, Luis Lara-Mejía, Herman Soto-Molina, Maritza Ramos-Ramírez, Diana Flores-Estrada and Jaime de la Garza

    Citation: BMC Cancer 2020 20:829

    Content type: Research article

    Published on:

  46. Existing imaging techniques have a low ability to detect lymph node metastasis (LNM) of gallbladder cancer (GBC). Gallbladder removal by laparoscopic cholecystectomy can provide pathological information regard...

    Authors: Yingnan Yang, Zhuolong Tu, Huajie Cai, Bingren Hu, Chentao Ye and Jinfu Tu

    Citation: BMC Cancer 2020 20:828

    Content type: Research article

    Published on:

  47. Peritoneal metastasis is the most frequent failure in gastric cancer. This study evaluated the role of prophylactic chemotherapeutic hyperthermic intraperitoneal perfusion (CHIP) in patients after D2 dissection.

    Authors: Lucheng Zhu, Zhizheng Xu, Yajun Wu, Pengyuan Liu, Jianing Qian, Shuhuan Yu, Bing Xia, Jianjun Lai, Shenglin Ma and Zhibing Wu

    Citation: BMC Cancer 2020 20:827

    Content type: Research article

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  48. Role of tumor markers in gall bladder carcinoma (GBC) is not well established. We evaluated the prognostic value of carbohydrate antigen 19–9 (CA19–9) and carcinoma embryonic antigen (CEA) in patients with GBC.

    Authors: Ashish Sachan, Sundeep Singh Saluja, Phani Kumar Nekarakanti, Nimisha, Bhawna Mahajan, Hirdaya H. Nag and Pramod K. Mishra

    Citation: BMC Cancer 2020 20:826

    Content type: Research article

    Published on:

  49. Malignant pleural effusion (MPE) causes substantial symptomatic burden in advanced malignancy. Although pleural fluid cytology is a commonly accepted gold standard of diagnosis, its low diagnostic yield is a c...

    Authors: Hayoung Choi, Yousang Ko and Chang Youl Lee

    Citation: BMC Cancer 2020 20:825

    Content type: Research article

    Published on:

  50. FOLFOXIRI (fluorouracil, leucovorin, oxaliplatin, and irinotecan) plus bevacizumab has shown to be one of the therapeutic regimens in first line with the highest activity in patients (pts.) with metastatic col...

    Authors: Angela Damato, Francesco Iachetta, Lorenzo Antonuzzo, Guglielmo Nasti, Francesca Bergamo, Roberto Bordonaro, Evaristo Maiello, Alberto Zaniboni, Giuseppe Tonini, Alessandra Romagnani, Annalisa Berselli, Nicola Normanno and Carmine Pinto

    Citation: BMC Cancer 2020 20:822

    Content type: Study protocol

    Published on:

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