A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy options are limited in salvage therapy. This is the first study to evaluate a bendamu...
Authors: Therasa Kim, He Yun Choi, Hyun-Seo Lee, Sung-Hoon Jung, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee, Hee-Doo Yoo and Deok-Hwan Yang
The phenomenon of chemotherapy-resistant cancers has necessitated the development of new therapeutics as well as the identification of specific prognostic markers to predict the response to novel drugs. Primar...
Authors: Anna A. Nushtaeva, Grigory A. Stepanov, Dmitry V. Semenov, Evgeny S. Juravlev, Evgenia A. Balahonova, Alexey V. Gerasimov, Sergey V. Sidorov, Eugeniy I. Savelyev, Elena V. Kuligina, Vladimir A. Richter and Olga A. Koval
Medication adherence refers to whether a patient takes medication according to the frequency prescribed, or continues to take a prescribed medication. Inadequate adherence to medication may cause alterations i...
Authors: Yunxin He, Eng Hooi Tan, Andrea Li Ann Wong, Chuan Chien Tan, Patrick Wong, Soo Chin Lee and Bee Choo Tai
Telomerase activity is required for both initiation and maintenance of tumorigenesis and over 90% cancers overexpress telomerase. Therefore, telomerase targeting has emerged as a potential strategy for cancer ...
Authors: Peter Solomon, Yuying Dong, Shaillay Dogra and Romi Gupta
Multiple myeloma (MM) patients with t(14;20) have a poor prognosis and their outcome has not improved following the introduction of bortezomib (Bzb). The mechanism underlying the resistance to proteasome inhib...
Authors: Ya-Wei Qiang, Shiqiao Ye, Yuhua Huang, Yu Chen, Frits Van Rhee, Joshua Epstein, Brian A. Walker, Gareth J. Morgan and Faith E. Davies
Infiltration into lymphatic vessels is a critical step in breast cancer metastasis. Lymphatics undergo changes that facilitate metastasis as a result of activation of the cells lining lymphatic vessels, lympha...
Authors: Alexandra R. Harris, Matthew J. Perez and Jennifer M. Munson
Interleukin-2 (IL-2) is an important immunotherapy cytokine for various diseases including cancer. Some studies reported the efficacy and safety on cisplatin combined with IL-2 versus cisplatin alone for treat...
Authors: Liping Han, Qiufang Jiang, Wei Yao, Tian Fu and Qingdi Zeng
The theory of field effect suggests that the tumor-adjacent area, besides histopathologically normal, undergoes genetic and epigenetic changes that can eventually affect epithelial homeostasis, predisposing th...
Authors: Camile B. Lopes, Leandro L. Magalhães, Carolina R. Teófilo, Ana Paula N. N. Alves, Raquel C. Montenegro, Massimo Negrini and Ândrea Ribeiro-dos-Santos
Epithelial-to-mesenchymal transition (EMT) is one mechanism of carcinoma migration, while complex tumour migration or bulk migration is another - best demontrated by tumour cells invading blood vessels.
Authors: Martin Zacharias, Luka Brcic, Sylvia Eidenhammer and Helmut Popper
Approximately 900 children/adolescents are treated with radiotherapy (RT) every year in France. However, among the 80% of survivors, the cumulative incidence of long-term morbidity – including second malignanc...
Authors: Valérie Bernier-chastagner, Liza Hettal, Véronique Gillon, Laurinda Fernandes, Cécile Huin-schohn, Marion Vazel, Priscillia Tosti, Julia Salleron, Aurélie François, Elise Cérimèle, Sandrine Perreira, Didier Peiffert, Pascal Chastagner and Guillaume Vogin
High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggest...
Authors: Christopher Platais, Raghu Radhakrishnan, Sven Niklander Ebensberger, Richard Morgan, Daniel W. Lambert and Keith D. Hunter
LIM and SH3 protein 1 (LASP1) is upregulated in several types of human cancer and implicated in cancer progression. However, the expression and intrinsic function of LASP1 in glioblastoma (GBM) remains unclear.
Authors: Chuanhong Zhong, Yitian Chen, Bei Tao, Lilei Peng, Tangming Peng, Xiaobo Yang, Xiangguo Xia and Ligang Chen
People aged 40–60 years with a family history (FH) of colorectal cancer (CRC) in 1st degree relatives (FDRs) have a 2- to 4-fold increased risk of CRC compared to the average risk population. Therefore, expert...
Authors: Kaja Tikk, Korbinian Weigl, Michael Hoffmeister, Svitlana Igel, Matthias Schwab, Jochen Hampe, Stefanie J. Klug, Ulrich Mansmann, Frank Kolligs and Hermann Brenner
Trans-arterial radio-embolization (TARE) is an emerging treatment for the management of hepatocellular carcinoma (HCC). TARE may compete with systemic chemotherapy, sorafenib, in intermediate stage patients wi...
Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O
Authors: Jeon Hwang-Bo, Mun Gyeong Bae, Jong-Hwa Park and In Sik Chung
Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the a...
Authors: Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, Jeong Su Oh and Jae-Sung Kim
Usually misdiagnosed, Inflammatory Breast Cancer (IBC) is the most aggressive form of non-metastatic breast cancer. This orphan disease is more frequent in North Africa. Despite intensive treatment, the surviv...
Authors: Meriem Slaoui, Abdou Azaque Zoure, Fatima Zahra Mouh, Youssef Bensouda, Mohammed El Mzibri, Youssef Bakri and Mariam Amrani
Cancer is the second leading cause of death in the Caribbean, including the islands of Trinidad and Tobago (TT). The population of TT consists of over 1.3 million people with diverse ancestral and sociocultura...
Authors: Wayne A. Warner, Tammy Y. Lee, Kimberly Badal, Tanisha M. Williams, Smriti Bajracharya, Vasavi Sundaram, Nigel A. Bascombe, Ravi Maharaj, Marjorie Lamont-Greene, Allana Roach, Melissa Bondy, Matthew J. Ellis, Timothy R. Rebbeck, Simeon Slovacek, Jingqin Luo, Adetunji T. Toriola…
HER2 over-expression is related with a poor prognosis in patients with invasive breast cancer tumors. Clinical associations have reported that somatic mutations of p53 more frequently detected in cases of spor...
Authors: A. A. Román-Rosales, E. García-Villa, L. A. Herrera, P. Gariglio and J. Díaz-Chávez
A major challenge for those living with cancers of the upper gastrointestinal tract (oesophagus, stomach and pancreas), is the impact of the disease and treatment on nutritional status and quality of life. People...
Authors: Lauren Hanna, Catherine E. Huggins, Kate Furness, Mary Anne Silvers, June Savva, Helena Frawley, Daniel Croagh, Paul Cashin, Liang Low, Judith Bauer, Helen Truby and Terrence Haines
The Union for International Cancer Control (UICC) tumor-node-metastasis (TNM) classification is a key gastric cancer prognosis system. This study aimed to create a new TNM system to provide a reference for the...
Authors: Zhiqiong Wang, Mo Li, Zhen Xu, Yanlin Jiang, Huizi Gu, Ying Yu, Haitao Zhu, Hao Zhang, Ping Lu, Junchang Xin, Hong Xu and Caigang Liu
The purpose of this case report is to describe a conjunctiva and eyelid Kaposi’s sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infect...
Authors: Filipe Sousa Neves, Joana Braga, João Cardoso da Costa, Joaquim Sequeira and Sandra Prazeres
The role of forkhead-box A1 (FOXA1) and Androgen receptor (AR) in breast cancer (BC) has been extensively studied. However, the prognostic role of their co-expression in Estrogen receptor positive (ER+) BC has...
Authors: Nelson Rangel, Nicoletta Fortunati, Simona Osella-Abate, Laura Annaratone, Claudio Isella, Maria Graziella Catalano, Letizia Rinella, Jasna Metovic, Renzo Boldorini, Davide Balmativola, Pietro Ferrando, Francesca Marano, Paola Cassoni, Anna Sapino and Isabella Castellano
Anti-PD-1 and BRAF-inhibitors (BRAFi) have been approved as first-line treatments in advanced melanoma. To date, no prospective data are available to give the best sequence of treatment. The objective of this ...
Authors: M. Amini-Adle, N. Khanafer, M. Le-Bouar, G. Duru, S. Dalle and L. Thomas
Although originally identified as a putative metastasis suppressor, increasing studies have confirmed a possible role for Nm23-H1 in DNA repair, through the base excision repair and nucleotide excision repair ...
Authors: Ya Sheng, Mingfang Xu, Chongyi Li, Yanli Xiong, Yi Yang, Xunjie Kuang, Dong Wang and Xueqin Yang
