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  1. Bortezomib (BZM), alone or in combination with other chemotherapies, has displayed strong anticancer effects in several cancers. The efficacy of the combination of BZM and mitoxantrone (MTX) in treating prosta...

    Authors: Ying Zhang, Qiuzi Liu, Wei Wei, Guoan Zhang, Siyuan Yan, Rongrong Dai, Ying Sun, Dubo Su, Shun Lv, Yong Xia, Jing Li and Changlin Li

    Citation: BMC Cancer 2021 21:1101

    Content type: Research

    Published on:

  2. This study aimed to develop a reliable immune signature based on B-cell proportion to predict the prognosis and benefit of immunotherapy in LUAD.

    Authors: Yi Zhang, Xuewen Yin, Qi Wang, Xuming Song, Wenjie Xia, Qixing Mao, Bing Chen, Yingkuan Liang, Te Zhang, Lin Xu, Feng Jiang, Xinyu Xu and Gaochao Dong

    Citation: BMC Cancer 2021 21:1098

    Content type: Research

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  3. Pancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and recurrence after successful tumour resection. Intraoperative radiation th...

    Authors: Yun Sun Lee, Hyung Sun Kim, Yeona Cho, Ik Jae Lee, Hyo Jung Kim, Da Eun Lee, Hyeon Woong Kang and Joon Seong Park

    Citation: BMC Cancer 2021 21:1097

    Content type: Research

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  4. Lung adenocarcinoma (LUAD) is the most prevalent non-small cell lung cancer (NSCLC). Patients with LUAD have a poor 5-year survival rate. The use of immune checkpoint inhibitors (ICIs) for the treatment of LUA...

    Authors: Weishuang Ma, Jiaming Liang, Junjian Mo, Siyuan Zhang, Ningdong Hu, Dongbo Tian and Zisheng Chen

    Citation: BMC Cancer 2021 21:1096

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:1146

  5. We aimed to analyze the clinicopathological features and outcomes of patients with gastric-type of HPV-independent endocervical adenocarcinoma (GAS HPVI ECA), and compare them with non-GAS HPVI ECA cases.

    Authors: Lili Chen, Yizhen Niu, Xiaoyun Wan, Lina Yu, Xiaofei Zhang, Amanda Louise Strickland, Liya Dong, Feng Zhou and Weiguo Lu

    Citation: BMC Cancer 2021 21:1095

    Content type: Research

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  6. To ensure safe delivery of oncologic care during the COVID-19 pandemic, telemedicine has been rapidly adopted. However, little data exist on the impact of telemedicine on quality and accessibility of oncologic...

    Authors: Vivek Nimgaonkar, Charu Aggarwal, Abigail T. Berman, Peter Gabriel, Lawrence N. Shulman, John Kucharczuk, Megan Roy, Joshua M. Bauml, Aditi P. Singh, Roger B. Cohen, Corey J. Langer and Melina E. Marmarelis

    Citation: BMC Cancer 2021 21:1094

    Content type: Research article

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  7. An underlying cause of solid tumor resistance to chemotherapy treatment is diminished tumor blood supply, which leads to a hypoxic microenvironment, dependence on anaerobic energy metabolism, and impaired deli...

    Authors: Amy A. Kirkham, Karen King, Anil A. Joy, André B. Pelletier, John R. Mackey, Kelvin Young, Xiaofu Zhu, Judith Meza-Junco, Sanraj K. Basi, Julie Price Hiller, Tina Brkin, Bonnie Michalowski, Edith Pituskin, D. Ian Paterson, Kerry S. Courneya, Richard B. Thompson…

    Citation: BMC Cancer 2021 21:1093

    Content type: Study protocol

    Published on:

  8. In oncology, liquid biopsy is of major relevance from theranostic point of view. The searching for mutations in circulating tumor DNA (ctDNA) in case of colorectal cancers (CRCs) allows the optimization of pat...

    Authors: Alexis Overs, Mylène Flammang, Eric Hervouet, Laurent Bermont, Jean-Luc Pretet, Borg Christophe and Zohair Selmani

    Citation: BMC Cancer 2021 21:1092

    Content type: Research

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  9. Current opinions on whether surgical patients with cervical cancer should undergo para-aortic lymphadenectomy at the same time are inconsistent. The present study examined differences in survival outcomes with...

    Authors: Chunlin Chen, Hui Duan, Wenling Zhang, Hongwei Zhao, Li Wang, Shan Kang, Lihong Lin, Weidong Zhao, Yan Ni, Donglin Li, Jiaming Chen, Huijian Fan, Xiaolin Chen, Xiaonong Bin, Jinghe Lang and Ping Liu

    Citation: BMC Cancer 2021 21:1091

    Content type: Research

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  11. Genetic alterations are common in non-small cell lung cancer (NSCLC), and DNA mutations and translocations are targets for therapy. Copy number aberrations occur frequently in NSCLC tumors and may influence ge...

    Authors: Maria Moksnes Bjaanæs, Gro Nilsen, Ann Rita Halvorsen, Hege G. Russnes, Steinar Solberg, Lars Jørgensen, Odd Terje Brustugun, Ole Christian Lingjærde and Åslaug Helland

    Citation: BMC Cancer 2021 21:1089

    Content type: Research

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  12. The aminoisoquinoline FX-9 shows pro-apoptotic and antimitotic effects against lymphoblastic leukemia cells and prostate adenocarcinoma cells. In contrast, decreased cytotoxic effects against non-neoplastic bl...

    Authors: F. Weiner, J. T. Schille, D. Koczan, X.-F. Wu, M. Beller, C. Junghanss, M. Hewicker-Trautwein, H. Murua Escobar and I. Nolte

    Citation: BMC Cancer 2021 21:1088

    Content type: Research

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  13. Cancer remains one of the leading causes of death worldwide, despite the possibilities to detect early onset of the most common cancer types. The search for the optimal therapy is complicated by the cancer div...

    Authors: Zane Simsone, Tālivaldis Freivalds, Dina Bēma, Indra Miķelsone, Liene Patetko, Juris Bērziņš, Līga Harju and Indulis Buiķis

    Citation: BMC Cancer 2021 21:1087

    Content type: Research

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  14. Perioperative FLOT (5-fluorouracil, oxaliplatin and docetaxel) has recently become the gold standard treatment for fit patients with operable gastric (GC) or gastroesophageal (GEJ) adenocarcinoma, getting a 5-...

    Authors: Elisa Giommoni, Daniele Lavacchi, Giuseppe Tirino, Lorenzo Fornaro, Francesco Iachetta, Carmelo Pozzo, Maria Antonietta Satolli, Andrea Spallanzani, Marco Puzzoni, Silvia Stragliotto, Michele Sisani, Vincenzo Formica, Filippo Giovanardi, Antonia Strippoli, Michele Prisciandaro, Samantha Di Donato…

    Citation: BMC Cancer 2021 21:1086

    Content type: Research

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  15. Circular RNAs (circRNAs) are implicated in the development of oral squamous cell carcinoma (OSCC). The aim of current research is to elucidate the role and mechanism of circ_0011946 in the functional behaviors...

    Authors: Ying Zhou, Shuhong Zhang, Zhonghan Min, Zhongwei Yu, Huaiwei Zhang and Jiao Jiao

    Citation: BMC Cancer 2021 21:1085

    Content type: Research article

    Published on:

  16. Little is known on the gender-specific effect and potential role of non-linear associations between metabolic syndrome (MetS) components and liver cancer risk. We evaluated these associations based on the UK B...

    Authors: Bin Xia, Jianjun Peng, De Toni Enrico, Kuiqing Lu, Eddie C. Cheung, Zichong Kuo, Qiangsheng He, Yan Tang, Anran Liu, Die Fan, Changhua Zhang, Yulong He, Yihang Pan and Jinqiu Yuan

    Citation: BMC Cancer 2021 21:1084

    Content type: Research

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  17. The aim of the study was to estimate the minimally important difference (MID) for interpreting group-level change over time, both within a group and between groups, for the European Organisation for Research a...

    Authors: Eva M. Gamper, Jammbe Z. Musoro, Corneel Coens, Jean-Jacques Stelmes, Claudette Falato, Mogens Groenvold, Galina Velikova, Kim Cocks, Hans-Henning Flechtner, Madeleine T. King and Andrew Bottomley

    Citation: BMC Cancer 2021 21:1083

    Content type: Research article

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  18. Alcohol consumption and smoking are the leading risk factors for laryngeal cancer (LC). Understanding the variations in disease burden of LC attributable to alcohol use and smoking is critical for LC prevention.

    Authors: Qiang-Wei Zhang, Jing-Yuan Wang, Xiao-Feng Qiao, Tong-Li Li and Xin Li

    Citation: BMC Cancer 2021 21:1082

    Content type: Research

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  19. Text message-delivered interventions have potential to prevent weight regain and maintain diet and physical activity behaviours through extending contact with participants following initial weight loss, lifest...

    Authors: Jennifer R. Job, Elizabeth G. Eakin, Marina M. Reeves and Brianna S. Fjeldsoe

    Citation: BMC Cancer 2021 21:1081

    Content type: Research

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  20. To compare the value of fluorodeoxyglucose positron emission tomography (FDG-PET)/computed tomography (CT) and magnetic resonance imaging (MRI) in differentiating benign and malignant ovarian or adnexal tumors.

    Authors: Xianwen Hu, Dandan Li, Zhigang Liang, Yan Liao, Ling Yang, Rui Wang, Pan Wang and Jiong Cai

    Citation: BMC Cancer 2021 21:1080

    Content type: Research

    Published on:

  21. Activation of the oncogene yes-associated protein (YAP) is frequently detected in intrahepatic cholangiocarcinoma (iCCA); however, the expression pattern and the functional impact of its paralogue WW domain-conta...

    Authors: Marcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M. E. Weiler, Carsten Sticht, Carolina De La Torre, Melina Rausch, Thomas Albrecht, Niels Grabe, Lea Duwe, Jesper B. Andersen, Bruno C. Köhler, Christoph Springfeld, Arianeb Mehrabi…

    Citation: BMC Cancer 2021 21:1079

    Content type: Research

    Published on:

  22. Cervical cancer is a common malignancy of the female genital tract. Treatment options for cervical cancer patients diagnosed at FIGO (2009) stage IB2 and IIA2 remains controversial.

    Authors: Jing Cheng, Beibei Liu, Biao Wang, Xicui Long, Zhihong Li, Ruili Chen, Ruiting Wu and Lin Xu

    Citation: BMC Cancer 2021 21:1078

    Content type: Research

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  23. The benefits of postoperative chemotherapy in patients with estrogen receptor (ER)-positive breast cancer remain unclear. The use of tumor grade, Ki-67, or ER expression failed to provide an accurate prognosis...

    Authors: Fumine Tsukamoto, Koji Arihiro, Mina Takahashi, Ken-ichi Ito, Shozo Ohsumi, Seiki Takashima, Takaaki Oba, Masayuki Yoshida, Kazuki Kishi, Keisuke Yamagishi and Takayuki Kinoshita

    Citation: BMC Cancer 2021 21:1077

    Content type: Research article

    Published on:

  24. Approximately 20% of MM patients harbor glucocorticoid (GC) resistance and are not responsive to therapeutic effect. Chaperoneheat-shock proteins Hsp90 is needed for ligand docking, The imbalance of Hsp90/GRα ...

    Authors: Shenghao Wu, Yuemiao Chen, Xueshuang Wang, Shanshan Weng, Wenjin Zhou and Zhen Liu

    Citation: BMC Cancer 2021 21:1076

    Content type: Research

    Published on:

  25. Monitoring circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs), known as liquid biopsies, continue to be developed as diagnostic and prognostic markers for a wide variety of cancer indications, ma...

    Authors: Nidal Muhanna, Donovan Eu, Harley H. L. Chan, Catriona Douglas, Jason L. Townson, Marco A. Di Grappa, Reza M. Mohamadi, Shana O. Kelley, Scott V. Bratman and Jonathan C. Irish

    Citation: BMC Cancer 2021 21:1075

    Content type: Research article

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  26. The human miR-17-92 polycistron is the first reported and most well-studied onco-miRNA with a cluster of seven miRNAs. miR-17-5p, a member of the miR-17-92 family, plays an important role in tumor cell prolife...

    Authors: Qiang Huang, Yu-Jie Shen, Chi-Yao Hsueh, Yang Guo, Yi-Fan Zhang, Jiao-Yu Li and Liang Zhou

    Citation: BMC Cancer 2021 21:1074

    Content type: Research

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  27. This study aimed to evaluate the feasibility, safety, and efficacy of postoperative adjuvant chemotherapy with docetaxel/cisplatin/S-1 (DCS) following S-1 therapy in patients with stage III gastric cancer afte...

    Authors: Noriyuki Hirahara, Takeshi Matsubara, Shunsuke Kaji, Tetsu Yamamoto, Ryoji Hyakudomi, Kiyoe Takai, Kazunari Ishitobi, Yuki Uchida and Yoshitsugu Tajima

    Citation: BMC Cancer 2021 21:1073

    Content type: Research

    Published on:

  29. The incidence of head and neck squamous cell carcinoma (HNSCC) in the French West Indies (FWI) is relatively high, despite a low prevalence of tobacco smoking and alcohol drinking. Little is known about other ...

    Authors: Aviane Auguste, Clarisse Joachim, Jacqueline Deloumeaux, Stanie Gaete, Léah Michineau, Cécile Herrmann-Storck, Suzy Duflo and Danièle Luce

    Citation: BMC Cancer 2021 21:1071

    Content type: Research

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  30. Emerging research suggests that survivors of childhood and adolescent cancers are at risk for morbidity and mortality associated with air pollutants. However, caregiver perceptions of the effects of air pollut...

    Authors: Austin R. Waters, Echo L. Warner, Perla L. Vaca Lopez, Anne C. Kirchhoff and Judy Y. Ou

    Citation: BMC Cancer 2021 21:1070

    Content type: Research article

    Published on:

  31. Colorectal cancer (CRC) represents one of the major malignant cancers in the world. It has been demonstrated that long non-coding RNAs (lncRNAs) can cause great influences on various human cancers. Though MCF....

    Authors: Wencheng Kong, Hui Li, Lesi Xie, Guangxing Cui, Weigang Gu, Hongchen Zhang, Wencong Ma and Yifeng Zhou

    Citation: BMC Cancer 2021 21:1069

    Content type: Research article

    Published on:

  33. As a critical feature of cancers, stemness is acknowledged as a contributor to the development of drug resistance in gastric cancer (GC). LncRNAs have been revealed to participate in this process. In this stud...

    Authors: Quan Jiang, Hao Chen, Zhaoqing Tang, Jie Sun, Yuanyuan Ruan, Fenglin Liu and Yihong Sun

    Citation: BMC Cancer 2021 21:1067

    Content type: Research

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  34. Smoking increases DNA methylation and DNA damage, and DNA damage acts as a vital cause of tumor development. The DNA methyltransferase 3B (DNMT3B) enhances promoter activity and methylation of tumor suppressor...

    Authors: Chia-Chen Huang, Chung-Yu Lai, Chin-Hung Tsai, Jiun-Yao Wang and Ruey-Hong Wong

    Citation: BMC Cancer 2021 21:1066

    Content type: Research

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  35. The incidence of depression and anxiety is higher in patients with breast cancer than in the general population. We evaluated the degree of depression and anxiety and investigated the changes in patients with ...

    Authors: Jeeyeon Lee, Jin Hyang Jung, Wan Wook Kim, Byeongju Kang, Jungmin Woo, Hyo-Deog Rim, Yee Soo Chae, Soo Jung Lee, Gi Hwan Kim, Won Kee Lee and Ho Yong Park

    Citation: BMC Cancer 2021 21:1065

    Content type: Research

    Published on:

  36. The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that informs clinical decisions regarding recurrence and overall survival in most epithelial cancers. Radiotherapy for head and nec...

    Authors: Yumiko Kawashita, Masayasu Kitamura, Sakiko Soutome, Takashi Ukai, Masahiro Umeda and Thoshiyuki Saito

    Citation: BMC Cancer 2021 21:1064

    Content type: Research

    Published on:

  37. Transarterial chemoembolization (TACE) is an effective treatment for patients with hepatocellular carcinoma (HCC). However, the impact of hepatitis B viral (HBV) infection and body mass index (BMI) on TACE is ...

    Authors: Yuan-dong Sun, Hao Zhang, Ye-qiang Chen, Chun-xue Wu, Miao-ling Chen, Hui-rong Xu, Shuo Wang, Jing-zhou Liu and Jian-jun Han

    Citation: BMC Cancer 2021 21:1063

    Content type: Research article

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  38. Basic leucine zipper ATF-like transcription factor 2 (BATF2) has been reported to participate in the occurrence and development of some malignancies. Herein, we aimed to explore the expression pattern and clin...

    Authors: Yingying Lin, Xusheng Zhou, Wei Peng, Jing Wu, Xiufeng Wu, Yan Chen and Zhaolei Cui

    Citation: BMC Cancer 2021 21:1062

    Content type: Research article

    Published on:

  39. Neuroblastoma (NB) patients with MYCN amplification or overexpression respond poorly to current therapies and exhibit extremely poor clinical outcomes. PI3K-mTOR signaling-driven deregulation of protein synthe...

    Authors: Matthew J. Kling, Connor N. Griggs, Erin M. McIntyre, Gracey Alexander, Sutapa Ray, Kishore B. Challagundla, Shantaram S. Joshi, Don W. Coulter and Nagendra K. Chaturvedi

    Citation: BMC Cancer 2021 21:1061

    Content type: Research article

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  40. For patients with esophageal adenocarcinoma or cancer of the gastroesophageal junction, radical esophagectomy with 2-field lymphadenectomy is the cornerstone of the multimodality treatment with curative intent...

    Authors: E. Tagkalos, P. C. van der Sluis, F. Berlth, A. Poplawski, E. Hadzijusufovic, H. Lang, M. I. van Berge Henegouwen, S. S. Gisbertz, B. P. Müller-Stich, J. P. Ruurda, M. Schiesser, P. M. Schneider, R. van Hillegersberg and P. P. Grimminger

    Citation: BMC Cancer 2021 21:1060

    Content type: Study protocol

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  42. Artificial intelligence (AI) is increasingly being used in medical imaging analysis. We aimed to evaluate the diagnostic accuracy of AI models used for detection of lymph node metastasis on pre-operative stagi...

    Authors: Sergei Bedrikovetski, Nagendra N. Dudi-Venkata, Hidde M. Kroon, Warren Seow, Ryash Vather, Gustavo Carneiro, James W. Moore and Tarik Sammour

    Citation: BMC Cancer 2021 21:1058

    Content type: Research article

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  43. Brain metastases were rare in esophageal cancer patients. Using the Surveillance, Epidemiology, and End Results (SEER) database, the present study investigated the incidence, risk and prognostic factors of bra...

    Authors: Shizhao Cheng, Lei Yang, Xin Dai, Jing Wang and Xingpeng Han

    Citation: BMC Cancer 2021 21:1057

    Content type: Research

    Published on:

  44. Advanced gastric cancer sometimes causes macroscopic serosal change (MSC) due to direct invasion or inflammation. However, the prognostic significance of MSC remains unclear.

    Authors: Masahiro Yura, Takaki Yoshikawa, Takeyuki Wada, Sho Otsuki, Tsutomu Hayashi, Yukinori Yamagata, Hitoshi Katai and Toshirou Nishida

    Citation: BMC Cancer 2021 21:1056

    Content type: Research article

    Published on:

  45. Patient medical out-of-pocket expenses are thought to be rising worldwide yet data describing trends over time is scant. We evaluated trends of out-of-pocket expenses for patients in Australia with one of five...

    Authors: Astrid J. Rodriguez-Acevedo, Raymond J. Chan, Catherine M. Olsen, Nirmala Pandeya, David C. Whiteman and Louisa G. Gordon

    Citation: BMC Cancer 2021 21:1055

    Content type: Research article

    Published on:

  46. Cervical cancer is the tenth diagnosed cancer in the world. Early-stage and locally recurrent disease may be cured with radical surgery or chemo-radiotherapy. However, if disease persists or recurs, options ar...

    Authors: Elodie Coquan, Pierre-Emmanuel Brachet, Idlir Licaj, Alexandra Leconte, Marie Castera, Justine Lequesne, Emeline Meriaux, Isabelle Bonnet, Anais Lelaidier, Bénédicte Clarisse and Florence Joly

    Citation: BMC Cancer 2021 21:1054

    Content type: Study protocol

    Published on:

  48. Breast cancer is the second leading cause of cancer in the world. It is the commonest type of cancer in Ethiopia. Cognitive problems are common among breast cancer patients. The study aimed to assess cognitive...

    Authors: Edgeit Abebe, Tesfaye Tollesa, Mathewos Assefa, Zelalem Tilahun, Yohannes Dinku, Sofonyas Abebaw and Melkalem Mamuye

    Citation: BMC Cancer 2021 21:1052

    Content type: Research

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  49. Colorectal cancer (CRC) is the third most common cancer, worldwide. Recently, much attention has been given to the association between Dietary Approaches to Stop Hypertension (DASH) and CRC, however, data on c...

    Authors: Saeede Jafari Nasab, Matin Ghanavati, Pegah Rafiee, Alireza Bahrami, Nazanin Majidi, Cain C. T. Clark, Amir Sadeghi, Mohammad Houshyari and Ehsan Hejazi

    Citation: BMC Cancer 2021 21:1050

    Content type: Research

    Published on:

  50. Cell lines are often used to assess the resistance of anticancer drugs when in vivo analysis is not possible. However, the process for establishing anti-cancer drug resistance in cell cultures in vitro and the...

    Authors: Hoon Yu, Dong-Jin Kim, Hye-Young Choi, So Myoung Kim, Md. Intazur Rahaman, Young-Hoon Kim and So Won Kim

    Citation: BMC Cancer 2021 21:1049

    Content type: Research

    Published on:

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