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  1. Testosterone implants have been used for over eighty years to treat symptoms of hormone deficiency in pre and postmenopausal women. Evidence supports that androgens are breast protective. However, there is a l...

    Authors: Rebecca L. Glaser, Anne E. York and Constantine Dimitrakakis

    Citation: BMC Cancer 2019 19:1271

    Content type: Research article

    Published on:

  2. Nausea can be particularly prominent during the delayed period. Therefore, we performed a meta-analysis of the available randomised evidence to assess the average effect of palonosetron plus one-day dexamethas...

    Authors: Luigi Celio, Erminio Bonizzoni, Emma Zattarin, Paolo Codega, Filippo de Braud and Matti Aapro

    Citation: BMC Cancer 2019 19:1268

    Content type: Research article

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  3. Invasive mammary carcinomas that spontaneously develop in female cats are associated with high mortality, and resemble the most aggressive human breast cancers, especially triple-negative breast cancer (TNBC)....

    Authors: Elie Dagher, Violette Royer, Paul Buchet, Jérôme Abadie, Delphine Loussouarn, Mario Campone and Frédérique Nguyen

    Citation: BMC Cancer 2019 19:1267

    Content type: Research article

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  4. The clinical significance of hematogenous and lymphatic metastasis in ovarian cancer has been increasingly addressed, as it plays an imperative role in the formation of both intraperitoneal and distant metasta...

    Authors: Huiran Yue, Jieyu Wang, Ruifang Chen, Xiaoman Hou, Jun Li and Xin Lu

    Citation: BMC Cancer 2019 19:1266

    Content type: Research article

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  5. Esophageal squamous cell carcinoma (ESCC) is a fatal disease with poor prognosis. The predominant reason for ESCC-related death is distal metastasis. A comprehensive understanding of the molecular mechanism un...

    Authors: Yanan Jiang, Jing Zhang, Jimin Zhao, Zhenzhen Li, Hanyong Chen, Yan Qiao, Xinhuan Chen, Kangdong Liu and Ziming Dong

    Citation: BMC Cancer 2019 19:1264

    Content type: Research article

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  6. To date, patients with metastasized pancreatic ductal adenocarcinoma (PDAC M1) are regarded as a uniform collective. We hypothesize the existence of oligometastatic disease (OMD): a state of PDAC M1 disease wi...

    Authors: Alexander I. Damanakis, Luisa Ostertag, Dirk Waldschmidt, Fabian Kütting, Alexander Quaas, Patrick Plum, Christiane J. Bruns, Florian Gebauer and Felix Popp

    Citation: BMC Cancer 2019 19:1261

    Content type: Research article

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  7. SPINK4 is known as a gastrointestinal peptide in the gastrointestinal tract and is abundantly expressed in human goblet cells. The clinical significance of SPINK4 in colorectal cancer (CRC) is largely unknown.

    Authors: Xiaojie Wang, Qian Yu, Waleed M. Ghareeb, Yiyi Zhang, Xingrong Lu, Ying Huang, Shenghui Huang, Yanwu Sun, Jiayi Lin, Jin Liu and Pan Chi

    Citation: BMC Cancer 2019 19:1258

    Content type: Research article

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  8. Breast cancer risk, development, and treatment are influenced by genetic variation in certain genes, namely those involved in cell proliferation, tumor suppression, and drug metabolism. In turn, the relevance ...

    Authors: Laith N. AL-Eitan, Doaa M. Rababa’h, Mansour A. Alghamdi and Rame H. Khasawneh

    Citation: BMC Cancer 2019 19:1257

    Content type: Research article

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  9. Following publication of the original article [1], the authors reported that during the production process, Table 1 was omitted.

    Authors: Siaw Shi Boon, Zigui Chen, Jintao Li, Karen Y. C. Lee, Liuyang Cai, Rugang Zhong and Paul K. S. Chan

    Citation: BMC Cancer 2019 19:1255

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2019 19:1211

  10. Bag-1 (Bcl-2-associated athanogene) is a multifunctional anti-apoptotic protein frequently overexpressed in cancer. Bag-1 interacts with a variety of cellular targets including Hsp70/Hsc70 chaperones, Bcl-2, n...

    Authors: Tugba Kizilboga, Emine Arzu Baskale, Jale Yildiz, Izzet Mehmet Akcay, Ebru Zemheri, Nisan Denizce Can, Can Ozden, Salih Demir, Fikret Ezberci and Gizem Dinler-Doganay

    Citation: BMC Cancer 2019 19:1254

    Content type: Research article

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  11. A previous phase I/II C-TASK FORCE study of trifluridine/tipiracil plus bevacizumab for patients with heavily pretreated metastatic colorectal cancer (mCRC) showed promising activity with an acceptable toxicit...

    Authors: Daisuke Kotani, Yasutoshi Kuboki, Satoshi Horasawa, Asumi Kaneko, Yoshiaki Nakamura, Akihito Kawazoe, Hideaki Bando, Hiroya Taniguchi, Kohei Shitara, Takashi Kojima, Akihito Tsuji and Takayuki Yoshino

    Citation: BMC Cancer 2019 19:1253

    Content type: Research article

    Published on:

  12. Acute Myeloid Leukemia (AML) is a malignancy of myeloid precursor cells that arise from genomic alterations in the expression of key growth regulatory genes causing cells to assume an undifferentiated state an...

    Authors: Justin J. Montoya, Megan A. Turnidge, Daniel H. Wai, Apurvi R. Patel, David W. Lee, Vijay Gokhale, Laurence H. Hurley, Robert J. Arceci, Cynthia Wetmore and David O. Azorsa

    Citation: BMC Cancer 2019 19:1251

    Content type: Research article

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  13. Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Up to 50% will be refractory to conventional chemotherapy. It is now known that the majority of PLGG have activation of the MA...

    Authors: Sébastien Perreault, Valérie Larouche, Uri Tabori, Cynthia Hawkin, Sarah Lippé, Benjamin Ellezam, Jean-Claude Décarie, Yves Théoret, Marie-Élaine Métras, Serge Sultan, Édith Cantin, Marie-Ève Routhier, Maxime Caru, Geneviève Legault, Éric Bouffet, Lucie Lafay-Cousin…

    Citation: BMC Cancer 2019 19:1250

    Content type: Study protocol

    Published on:

  14. Following publication of the original article [1], the authors reported errors in Figure 3, Figure 14a, Figure 18, Figure 19b, Additional file 3 and Additional file 7.

    Authors: Shailima Rampogu, Ayoung Baek, Amir Zeb and Keun Woo Lee

    Citation: BMC Cancer 2019 19:1249

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2018 18:264

  15. The potential risk for cognitive impairment following surgery and anesthesia is a common concern, especially in the elderly and more fragile patients. The risk for various neurocognitive effects is thus an are...

    Authors: Haitao Sun, Guohua Zhang, Bolun Ai, Huimin Zhang, Xiangyi Kong, Wan-Ting Lee, Hui Zheng, Tao Yan and Li Sun

    Citation: BMC Cancer 2019 19:1248

    Content type: Research article

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  16. Previous studies have indicated that accompanying socially underserved cancer patients through Patient Navigator (PN) or PN-derived procedures improves therapy management and reassurance. At the Cancer Institu...

    Authors: K. G. Koffi, D. A. Silué, C. Laurent, K. Boidy, S. Koui, G. Compaci, Z. H. Adeba, I. Kamara, R. P. Botty, A. S. Bognini, I. Sanogo, F. Despas and G. Laurent

    Citation: BMC Cancer 2019 19:1247

    Content type: Research article

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  17. Myeloma cells retain B cell functions, considered to be potential antigen presenting cells, yet there is little information regarding promoting Th2 cell proliferation or the direct effects to myeloma on the Th...

    Authors: Faqing Tian, Bo Lu, Ziren Chen, Junru Liu, Delan Ji, Juheng Li, Meiqin Tang, Wei Zhu and Juan Li

    Citation: BMC Cancer 2019 19:1246

    Content type: Research article

    Published on:

  18. Formaldehyde, a widely used chemical, is considered a human carcinogen. We report the results of a meta-analyses of studies on the relationship between occupational exposure to formaldehyde and risk of non-Hod...

    Authors: Simona Catalani, Francesca Donato, Egidio Madeo, Pietro Apostoli, Giuseppe De Palma, Enrico Pira, Kenneth A. Mundt and Paolo Boffetta

    Citation: BMC Cancer 2019 19:1245

    Content type: Research article

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  19. The application of multiparametric magnetic resonance imaging (mpMRI) for diagnosis of prostate cancer has been recommended by the European Association of Urology (EAU), National Comprehensive Cancer Network (...

    Authors: Liang Zhen, Xiaoqiang Liu, Chen Yegang, Yang Yongjiao, Xu Yawei, Kang Jiaqi, Wang Xianhao, Song Yuxuan, Hu Rui, Zhang Wei and Ou Ningjing

    Citation: BMC Cancer 2019 19:1244

    Content type: Research article

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  20. The gut microbiota is an important modulator of immune, metabolic, psychological and cognitive mechanisms. Chemotherapy adversely affects the gut microbiota, inducing acute dysbiosis, and alters physiological ...

    Authors: Julie M. Deleemans, Faye Chleilat, Raylene A. Reimer, Jan-Willem Henning, Mohamad Baydoun, Katherine-Ann Piedalue, Andrew McLennan and Linda E. Carlson

    Citation: BMC Cancer 2019 19:1243

    Content type: Study protocol

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  21. Cell cycle analysis is important for cancer research. However, available methodologies have drawbacks including limited categorisation and reliance on fixation, staining or transformation. Multispectral analys...

    Authors: Jared M. Campbell, Abbas Habibalahi, Saabah Mahbub, Martin Gosnell, Ayad G. Anwer, Sharon Paton, Stan Gronthos and Ewa Goldys

    Citation: BMC Cancer 2019 19:1242

    Content type: Research article

    Published on:

  22. To investigate the incidence of non-cancer mortalities and prognostic factors associated with competitive causes of death in a homogeneous cohort of patients with locally advanced head and neck cancer treated ...

    Authors: I. Zapata, M. Alvarez, R. Hidalgo, B. Pajares, M. J. Garcia-Anaya, M. D. Toledo, J. M. Trigo, Y. Lupiañez-Perez, J. A. Medina and J. Jaime Gomez-Millan

    Citation: BMC Cancer 2019 19:1241

    Content type: Research article

    Published on:

  23. Tumor angiogenesis is vital for tumor growth. Recent evidence indicated that bone marrow-derived mesenchymal stem cells (BMSCs) can migrate to tumor sites and exert critical effects on tumor growth through dir...

    Authors: Chao Sun, Xingliang Dai, Dongliang Zhao, Haiyang Wang, Xiaoci Rong, Qiang Huang and Qing Lan

    Citation: BMC Cancer 2019 19:1240

    Content type: Research article

    Published on:

  24. Colorectal cancer (CRC) is still a leading cause of death worldwide. Recent studies have pointed to an important role of microRNAs in carcinogenesis. Several microRNAs are described as aberrantly expressed in ...

    Authors: Danuta Sastre, João Baiochi, Ildercilio Mota de Souza Lima, Felipe Canto de Souza, Amanda Cristina Corveloni, Carolina Hassib Thomé, Vitor Marcel Faça, Josiane Lilian dos Santos Schiavinato, Dimas Tadeu Covas and Rodrigo Alexandre Panepucci

    Citation: BMC Cancer 2019 19:1239

    Content type: Research article

    Published on:

  25. As a result of an author oversight in the original article [1], the legend of Figure 5A and C is inaccurate and one panel in Figure 5C (FOXM1N H929 cells shown in the top row, left) is wrong.

    Authors: Chunyan Gu, Xuefang Jing, Carol Holman, Ramakrishna Sompallae, Fenghuang Zhan, Guido Tricot, Ye Yang and Siegfried Janz

    Citation: BMC Cancer 2019 19:1238

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2018 18:1152

  26. Stereotactic irradiation (SBRT) is a standard of care for inoperable stage I lung cancer and brain oligometastases from lung cancer but is controversial for extracranial oligometastases. We assessed outcomes o...

    Authors: Manon Kissel, Isabelle Martel-Lafay, Justine Lequesne, Jean-Christophe Faivre, Cécile Le Péchoux, Dinu Stefan, Victor Barraux, Cédric Loiseau, Jean-Michel Grellard, Serge Danhier, Delphine Lerouge, Christos Chouaid, Radj Gervais and Juliette Thariat

    Citation: BMC Cancer 2019 19:1237

    Content type: Research article

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  27. The mechanistic (or mammalian) target of rapamycin (mTOR), a Ser/Thr kinase, associates with different subunits forming two functionally distinct complexes, mTORC1 and mTORC2, regulating a diverse set of cellu...

    Authors: Mehraj-U-Din Lone, Javed Miyan, Mohammad Asif, Showkat A. Malik, Parul Dubey, Varsha Singh, Kavita Singh, Kalyan Mitra, Deepali Pandey, Wahajul Haq, Himanshi Amita, Prince Kumar Singh, Wieland Kiess, Franziska Kaessner, Antje Garten and Smrati Bhadauria

    Citation: BMC Cancer 2019 19:1236

    Content type: Research article

    Published on:

  28. The aim of this study was to investigate how much the risks of recurrence and death are increased as a consequence of selecting fertility-sparing surgery (FSS) in young women with epithelial ovarian cancer (EOC).

    Authors: Hiroaki Kajiyama, Shiro Suzuki, Nobuhisa Yoshikawa, Michiyasu Kawai, Kimio Mizuno, Osamu Yamamuro, Tetsuro Nagasaka, Kiyosumi Shibata and Fumitaka Kikkawa

    Citation: BMC Cancer 2019 19:1235

    Content type: Research article

    Published on:

  29. Esophageal neuroendocrine carcinomas (NECs) are exceedingly rare and poorly understood. The aims of the retrospective study were to delineate the clinicopathologic features and prognosis of patients with the d...

    Authors: Lei Ye, Heng Lu, Lin Wu, Lei Zhang, Hui Shi, Hui Min Wu, Pin Tu, De Min Li and Fang Yu Wang

    Citation: BMC Cancer 2019 19:1234

    Content type: Research article

    Published on:

  30. Mouse and human studies support the promise of dry beans to improve metabolic health and to lower cancer risk. In overweight/obese patients with a history of colorectal polyps or cancer, the Beans to Enrich th...

    Authors: Xiaotao Zhang, Gladys Browman, Wesley Siu, Karen M. Basen-Engquist, Samir M. Hanash, Kristi L. Hoffman, Pablo C. Okhuysen, Paul Scheet, Joseph F. Petrosino, Scott Kopetz and Carrie R. Daniel

    Citation: BMC Cancer 2019 19:1233

    Content type: Study protocol

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  31. We sought to assess the prognostic significance of lymph node ratio (LNR) and N stage in patients undergoing D2 gastrectomy and adjuvant chemotherapy, S-1, and XELOX and to compare the efficacy of them accordi...

    Authors: Kabsoo Shin, Se Jun Park, Jinsoo Lee, Cho Hyun Park, Kyo Young Song, Han Hong Lee, Ho Seok Seo, Yoon Ju Jung, Jae Myung Park, Sung Hak Lee, Sang Young Roh and In-Ho Kim

    Citation: BMC Cancer 2019 19:1232

    Content type: Research article

    Published on:

  32. Genome-wide association studies (GWAS) have identified more than 40 colorectal cancer susceptibility loci, but only a small fraction of heritability was explained. To account for missing heritability, we inves...

    Authors: Nan Song, Jeeyoo Lee, Sooyoung Cho, Jeongseon Kim, Jae Hwan Oh and Aesun Shin

    Citation: BMC Cancer 2019 19:1231

    Content type: Research article

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  33. Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and re...

    Authors: Michael B. Jameson, Kirsten Gormly, David Espinoza, Wendy Hague, Gholamreza Asghari, Grahame Mark Jeffery, Timothy Jay Price, Christos Stelios Karapetis, Michael Arendse, James Armstrong, John Childs, Frank A. Frizelle, Sam Ngan, Andrew Stevenson, Martinus Oostendorp and Stephen P. Ackland

    Citation: BMC Cancer 2019 19:1229

    Content type: Study protocol

    Published on:

  34. To explain the association between adjuvant radiation therapy after breast conserving surgery (BCS RT) and overall survival (OS) by quantifying bias due to confounding in a sample of elderly breast cancer bene...

    Authors: Fabian Camacho, Roger Anderson and Gretchen Kimmick

    Citation: BMC Cancer 2019 19:1228

    Content type: Research article

    Published on:

  35. Following publication of the original article [1], the authors reported an error in Figure 2, where the color code of the text boxes is reversed. Figure 2-amended shows the correct color association between the t...

    Authors: Ainara Ruiz de Sabando, Edurne Urrutia Lafuente, Fermín García-Amigot, Angel Alonso Sánchez, Lourdes Morales Garofalo, Sira Moreno, Eva Ardanaz and Maria A. Ramos-Arroyo

    Citation: BMC Cancer 2019 19:1227

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2019 19:1145

  36. Neuroendocrine tumours (NETs) are rare malignancies characterised by its capacity to synthesise and secrete monoamines, due to its neuroendocrine origin. Its varied locations and symptoms have traditionally be...

    Authors: Josep Darbà and Alicia Marsà

    Citation: BMC Cancer 2019 19:1226

    Content type: Research article

    Published on:

  37. Mitochondria are considered a primary intracellular site of reactive oxygen species (ROS) generation. Generally, cancer cells with mitochondrial genetic abnormalities (copy number change and mutations) have es...

    Authors: Tarek Zaidieh, James R. Smith, Karen E. Ball and Qian An

    Citation: BMC Cancer 2019 19:1224

    Content type: Research article

    Published on:

  38. Texture analysis of medical images has been reported to be a reliable method for differential diagnosis of neoplasms. This study was to investigate the performance of textural features and the combined perform...

    Authors: Jing Yang, Xinli Guo, Hao Zhang, Weiwei Zhang, Jinen Song, Hui Xu and Xuelei Ma

    Citation: BMC Cancer 2019 19:1223

    Content type: Research article

    Published on:

  39. Neoadjuvant chemoradiotherapy is regarded as the standard of treatment for locally advanced lower rectal cancer, although some of these cases are systemic, and distant control may be inadequate. Neoadjuvant ch...

    Authors: Takuya Shiraishi, Takeshi Sasaki, Koji Ikeda, Yuichiro Tsukada, Yuji Nishizawa and Masaaki Ito

    Citation: BMC Cancer 2019 19:1222

    Content type: Research article

    Published on:

  40. Cervical cancer is a cancer of uterine cervix caused mostly by sexually-acquired infection called Human papillomavirus (HPV. In developing region of the globe, fewer than 50% of women with cervical malignancy ...

    Authors: Mulugeta Wassie, Zeleke Argaw, Yosief Tsige, Mesfin Abebe and Sezer Kisa

    Citation: BMC Cancer 2019 19:1221

    Content type: Research article

    Published on:

  41. Nivolumab is an immune checkpoint inhibitor (ICI) and is used for the treatment of advanced non-small cell lung cancer (NSCLC). Several immune-mediated neurological adverse events associated with ICIs have bee...

    Authors: Takashi Sakoh, Mami Kanzaki, Atsushi Miyamoto, Sayaka Mochizuki, Toshiyuki Kakumoto, Kenichiro Sato, Yoshikazu Uesaka and Kazuma Kishi

    Citation: BMC Cancer 2019 19:1220

    Content type: Case report

    Published on:

  42. The posterior-inferior border of symphysis (PIBS) point system is a novel vaginal dose-reporting method and is a simple and reliable method proposed by the Medical University of Vienna proposed for both extern...

    Authors: Juan Wang, Kai-shuo Zhang, Tao Wang, Zi Liu, Rui-hua Wang, Fu-quan Zhang, Lang Yu, Li Ran, Jian-li He, Ya-li Wang, Li-chun Wei, Mei Shi, Guo-qing Wang, Chao-qun Wu, Qi-jun Kang, Jie Yang…

    Citation: BMC Cancer 2019 19:1219

    Content type: Research article

    Published on:

  43. Consumption of moldy food has previously been identified as a risk factor for esophageal squamous cell carcinoma (ESCC) in high-risk countries; however, what contributing roles these dietary carcinogenic mycot...

    Authors: Kathy S. Xue, Lili Tang, Guiju Sun, Shaokang Wang, Xu Hu and Jia-Sheng Wang

    Citation: BMC Cancer 2019 19:1218

    Content type: Research article

    Published on:

  44. Granulocyte-colony stimulating factor (G-CSF) is increasingly been used to prevent febrile neutropenia (FN) associated with the administration of chemotherapy for various cancers. The most common adverse effec...

    Authors: Hideko Hoshina and Hiroyuki Takei

    Citation: BMC Cancer 2019 19:1217

    Content type: Case report

    Published on:

  45. Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association ...

    Authors: Eugenio Zoni, Martina Minoli, Cédric Bovet, Anne Wehrhan, Salvatore Piscuoglio, Charlotte K. Y. Ng, Peter C. Gray, Martin Spahn, George N. Thalmann and Marianna Kruithof-de Julio

    Citation: BMC Cancer 2019 19:1216

    Content type: Research article

    Published on:

  46. The optimal timing of surgery in relation to chemoradiation is still controversial. Retrospective analysis has demonstrated in the recent decades that the regression of adenocarcinoma can be slow and not compl...

    Authors: Igor Monsellato, Filippo Alongi, Elisa Bertocchi, Stefania Gori, Giacomo Ruffo, Elisa Cassinotti, Ludovica Baldarti, Luigi Boni, Graziano Pernazza, Fabio Pulighe, Carlo De Nisco, Roberto Perinotti, Emilio Morpurgo, Tania Contardo, Enzo Mammano, Ugo Elmore…

    Citation: BMC Cancer 2019 19:1215

    Content type: Study protocol

    Published on:

  47. Monocytes are a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC). However, the complex interactions between tumor cells and monocytes and their role in tumor invas...

    Authors: Christian Benzing, Hoyin Lam, Chi Man Tsang, Alexander Rimmer, Yoana Arroyo-Berdugo, Yolanda Calle and Claire M. Wells

    Citation: BMC Cancer 2019 19:1214

    Content type: Research article

    Published on:

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