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  1. Research article

    Impact of comorbid conditions on participation in an organised colorectal cancer screening programme: a cross-sectional study

    There is controversy regarding how comorbidity impacts on colorectal cancer screening, especially in the context of organised programmes. The aim of this study is to assess the effect of comorbidities on parti...

    Carolina Guiriguet, Guillem Pera, Antoni Castells, Pere Toran, Jaume Grau, Irene Rivero, Andrea Buron, Francesc Macià, Carmen Vela-Vallespín, Mercedes Vilarrubí-Estrella and Mercedes Marzo-Castillejo

    BMC Cancer 2017 17:524

    Published on: 7 August 2017

  2. Case report

    The clonal evolution of two distinct T315I-positive BCR-ABL1 subclones in a Philadelphia-positive acute lymphoblastic leukemia failing multiple lines of therapy: a case report

    The treatment of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) patients who harbor the T315I BCR-ABL1 mutation or who have two or more mutations in the same BCR-ABL1 molecule is parti...

    Caterina De Benedittis, Cristina Papayannidis, Claudia Venturi, Maria Chiara Abbenante, Stefania Paolini, Sarah Parisi, Chiara Sartor, Michele Cavo, Giovanni Martinelli and Simona Soverini

    BMC Cancer 2017 17:523

    Published on: 5 August 2017

  3. Research article

    Clinicopathological features and prognostic validity of WHO grading classification of SI-NENs

    The clinicopathological characteristics of small intestinal neuroendocrine neoplasms (SI-NENs) and the prognostic validity of WHO grading classification for SI-NENs are still unknown in Asian patients.

    Luohai Chen, Lin Zhou, Meng Zhang, Liang Shang, Panpan Zhang, Wei Wang, Cheng Fang, Jingnan Li, Tianming Xu, Huangying Tan, Pan Zhang, Meng Qiu, Xianjun Yu, Kaizhou Jin, Ye Chen, Huishan Chen…

    BMC Cancer 2017 17:521

    Published on: 4 August 2017

  4. Research article

    Outcome after resection of Adrenocortical Carcinoma liver metastases: a retrospective study

    Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (<15%). A surgical approach is recommended in selected patients if complete resection of distant metastasis can b...

    Johannes Baur, Tjark-Ole Büntemeyer, Felix Megerle, Timo Deutschbein, Christine Spitzweg, Marcus Quinkler, Peter Nawroth, Matthias Kroiss, Christoph-Thomas Germer, Martin Fassnacht and Ulrich Steger

    BMC Cancer 2017 17:522

    Published on: 4 August 2017

  5. Research article

    Complete surgical resection improves outcome in INRG high-risk patients with localized neuroblastoma older than 18 months

    Although several studies have been conducted on the role of surgery in localized neuroblastoma, the impact of surgical timing and extent of primary tumor resection on outcome in high-risk patients remains cont...

    Janina Fischer, Alexandra Pohl, Ruth Volland, Barbara Hero, Martin Dübbers, Grigore Cernaianu, Frank Berthold, Dietrich von Schweinitz and Thorsten Simon

    BMC Cancer 2017 17:520

    Published on: 4 August 2017

  6. Research article

    Frequency of Human papillomavirus in women attending cervical cancer screening program in Chile

    Human papillomavirus (HPV) is the etiological factor for cervical cancer and its precursor lesions. The characterization of HPV genotypes in preneoplastic lesions and cervical cancer c...

    Priscilla Brebi, Carmen Gloria Ili, Alejandra Andana, Doris Menzel, Jaime Lopez, Pablo Guzman, Angelica Melo, Kurt Buchegger and Juan C. Roa

    BMC Cancer 2017 17:518

    Published on: 3 August 2017

  7. Research article

    Pretreatment glycemic control status is an independent prognostic factor for cervical cancer patients receiving neoadjuvant chemotherapy for locally advanced disease

    To investigate whether poor glycemic control status has a negative impact on survival outcomes and tumor response to chemotherapy in patients receiving neoadjuvant chemotherapy (NACT) for locally advanced cerv...

    Jing Li, Ni-ya Ning, Qun-xian Rao, Rong Chen, Li-juan Wang and Zhong-qiu Lin

    BMC Cancer 2017 17:517

    Published on: 3 August 2017

  8. Study protocol

    Novel approaches to the prediction, diagnosis and treatment of cardiac late effects in survivors of childhood cancer: a multi-centre observational study

    Anthracycline-induced cardiac toxicity is a cause of significant morbidity and early mortality in survivors of childhood cancer. Current strategies for predicting which children are at greatest risk for toxici...

    Amy Skitch, Seema Mital, Luc Mertens, Peter Liu, Paul Kantor, Lars Grosse-Wortmann, Cedric Manlhiot, Mark Greenberg and Paul C Nathan

    BMC Cancer 2017 17:519

    Published on: 3 August 2017

  9. Research article

    Succinate dehydrogenase deficiency in a PDGFRA mutated GIST

    Most gastrointestinal stromal tumors (GISTs) harbor mutually exclusive gain of function mutations in the receptor tyrosine kinase (RTK) KIT (70–80%) or in the related receptor PDGFRA (~10%). These GISTs genera...

    Martin G. Belinsky, Kathy Q. Cai, Yan Zhou, Biao Luo, Jianming Pei, Lori Rink and Margaret von Mehren

    BMC Cancer 2017 17:512

    Published on: 2 August 2017

  10. Research article

    Hybrid clone cells derived from human breast epithelial cells and human breast cancer cells exhibit properties of cancer stem/initiating cells

    The biological phenomenon of cell fusion has been associated with cancer progression since it was determined that normal cell × tumor cell fusion-derived hybrid cells could exhibit novel properties, such as en...

    Daria Gauck, Silvia Keil, Bernd Niggemann, Kurt S. Zänker and Thomas Dittmar

    BMC Cancer 2017 17:515

    Published on: 2 August 2017

  11. Research article

    Lymphocyte count or percentage: which can better predict the prognosis of advanced cancer patients following palliative care?

    The lymphocytes played an important role in the natural history of cancer. The aim of this study was to explore the prognostic value of lymphocyte count and percentage for survival in advanced cancer patients ...

    Weiwei Zhao, Peng Wang, Huixun Jia, Menglei Chen, Xiaoli Gu, Minghui Liu, Zhe Zhang, Wenwu Cheng and Zhenyu Wu

    BMC Cancer 2017 17:514

    Published on: 2 August 2017

  12. Research article

    Outcome and toxicity of radical radiotherapy or concurrent Chemoradiotherapy for elderly cervical cancer women

    Concurrent chemoradiotherapy (CCRT) is the standard treatment for local advanced cervical cancer. However, for elderly patients, studies are limited and the outcomes are controversial. We retrospectively analy...

    Weiping Wang, Xiaorong Hou, Junfang Yan, Jie Shen, Xin Lian, Shuai Sun, Zhikai Liu, Qingyu Meng, Dunhuang Wang, Mei Zhao, Jie Qiu, Ke Hu and Fuquan Zhang

    BMC Cancer 2017 17:510

    Published on: 1 August 2017

  13. Study protocol

    PUREAIR protocol: randomized controlled trial of intensive pulmonary rehabilitation versus standard care in patients undergoing surgical resection for lung cancer

    Non-small cell lung cancer is the most common type of lung cancer. Surgery is proven to be the most effective treatment in early stages, despite its potential impact on quality of life. Pulmonary rehabilitatio...

    Stefania Fugazzaro, Stefania Costi, Carlotta Mainini, Besa Kopliku, Cristian Rapicetta, Roberto Piro, Roberta Bardelli, Patricia Filipa Sobral Rebelo, Carla Galeone, Giorgio Sgarbi, Filippo Lococo, Massimiliano Paci, Tommaso Ricchetti, Silvio Cavuto, Domenico Franco Merlo and Sara Tenconi

    BMC Cancer 2017 17:508

    Published on: 31 July 2017

  14. Study protocol

    Randomized controlled trial of S-1 maintenance therapy in metastatic esophagogastric cancer – the multinational MATEO study

    The optimal duration of firstline chemotherapy in metastatic esophagogastric cancer is unknown. In most clinical trials therapy was given until tumour progression or limiting toxicity. Maintenance concepts aim...

    Georg-Martin Haag, Gertraud Stocker, Julia Quidde, Dirk Jaeger and Florian Lordick

    BMC Cancer 2017 17:509

    Published on: 31 July 2017

  15. Research article

    Prognostic value of total tumor volume in patients with nasopharyngeal carcinoma treated with intensity-modulated radiotherapy

    Few studies have evaluated the prognostic value of total tumor volume (TTV), which reflects both the primary tumor volume and nodal tumor volume, in NPC. Furthermore, the relationship between TTV and survival ...

    Shao-Bo Liang, Jian-Jian Teng, Xue-Feng Hu, Xing-Li Yang, Min Luo, Xiao-Na Fang, Dong-Sheng Liu, Yong Chen and Li-Wu Fu

    BMC Cancer 2017 17:506

    Published on: 28 July 2017

  16. Study protocol

    Alliance for clinical trials in oncology (ALLIANCE) trial A021501: preoperative extended chemotherapy vs. chemotherapy plus hypofractionated radiation therapy for borderline resectable adenocarcinoma of the head of the pancreas

    Borderline resectable pancreatic cancers infiltrate into adjacent vascular structures to an extent that makes an R0 resection unlikely when pancreatectomy is performed de novo. In a pilot study, Alliance for C...

    Matthew H. G. Katz, Fang-Shu Ou, Joseph M. Herman, Syed A. Ahmad, Brian Wolpin, Robert Marsh, Spencer Behr, Qian Shi, Michael Chuong, Lawrence H. Schwartz, Wendy Frankel, Eric Collisson, Eugene J. Koay, JoLeen M. Hubbard, James L. Leenstra, Jeffrey Meyerhardt…

    BMC Cancer 2017 17:505

    Published on: 27 July 2017

  17. Research article

    Increased ERCC1 expression is linked to chromosomal aberrations and adverse tumor biology in prostate cancer

    Animal model experiments have suggested a role of the DNA repair protein ERCC1 (Excision Repair Cross-Complementation Group 1) in prostate cancer progression.

    Frank Jacobsen, Billurvan Taskin, Nathaniel Melling, Charlotte Sauer, Corinna Wittmer, Claudia Hube-Magg, Martina Kluth, Ronald Simon, Dirk Pehrke, Burkhard Beyer, Thomas Steuber, Imke Thederan, Guido Sauter, Thorsten Schlomm, Waldemar Wilczak, Katharina Möller…

    BMC Cancer 2017 17:504

    Published on: 26 July 2017

  18. Research article

    Influence of chemotherapeutic drug-related gene polymorphisms on toxicity and survival of early breast cancer patients receiving adjuvant chemotherapy

    We investigated whether GSTT1 (“null” allele), GSTM1 (“null”allele), GSTP1 (A313G), RFC1 (G80A), MTHFR (C677T), TS (2R/3R) polymorphisms were associated with toxicity and survival in patients with early breast ca...

    Vienna Ludovini, Cinzia Antognelli, Antonio Rulli, Jennifer Foglietta, Lorenza Pistola, Rulli Eliana, Irene Floriani, Giuseppe Nocentini, Francesca Romana Tofanetti, Simonetta Piattoni, Elisa Minenza, Vincenzo Nicola Talesa, Angelo Sidoni, Maurizio Tonato, Lucio Crinò and Stefania Gori

    BMC Cancer 2017 17:502

    Published on: 26 July 2017

  19. Case report

    Vaginal metastasis as the initial presentation of leiomyosarcoma: a case report

    Uterine leiomyosarcomas are very rare and highly aggressive tumors that have a high rate of recurrence and poor prognosis, even when early diagnosed. Due to their relative rarity, there is limited research on ...

    Cecilia Villalaín-González, Álvaro Tejerizo-García, Patricia Lopez-Garcia, Gregorio López-González, Ma. Reyes Oliver-Perez and Jesús S. Jiménez-López

    BMC Cancer 2017 17:503

    Published on: 26 July 2017

  20. Study protocol

    Whole brain radiotherapy versus stereotactic radiosurgery for 4–10 brain metastases: a phase III randomised multicentre trial

    Maintenance of quality of life is the primary goal during treatment of brain metastases (BM). This is a protocol of an ongoing phase III randomised multicentre study. This study aims to determine the exact add...

    Jaap D. Zindler, Anna M. E. Bruynzeel, Daniëlle B. P. Eekers, Coen W. Hurkmans, Ans Swinnen and Philippe Lambin

    BMC Cancer 2017 17:500

    Published on: 25 July 2017

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