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  1. Ovarian cancer is a common cancer type in women and is often associated with onset of malnutrition. Total parenteral nutrition (TPN) is a nutritional intervention method that has been reported to have controve...

    Authors: Xin Yan, Sanyuan Zhang, Junmei Jia, Jiaolin Yang, Yilai Song and Haoran Duan

    Citation: BMC Cancer 2021 21:799

    Content type: Research

    Published on:

  2. Tamoxifen (TAM) and Toremifene (TOR), two kinds of selective estrogen receptor modulators (SERMs), have equal efficacy in breast cancer patients. However, TAM has been proved to affect serum lipid profiles and...

    Authors: Dandan Song, Yingying Hu, Biyu Diao, Rongrong Miao, Baodan Zhang, Yangjun Cai, Hanqian Zeng, Yuru Zhang and Xiaoqu Hu

    Citation: BMC Cancer 2021 21:798

    Content type: Research article

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  3. MutL Homolog 1 (MLH1) promotor methylation is associated with microsatellite instability high colorectal cancer (CRC). The strong correlation between methylation status and cancer development and progression has ...

    Authors: Danyi Wang, Dennis O’Rourke, Jorge F. Sanchez-Garcia, Ti Cai, Juergen Scheuenpflug and Zheng Feng

    Citation: BMC Cancer 2021 21:797

    Content type: Research

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  4. Adjuvant chemotherapy has changed the paradigm in resectable gastric cancer. S-1 is an oral chemotherapeutic with promising efficacy in Asia. However, comparisons with close observation or platinum-based doubl...

    Authors: Chih-Chieh Yen, Yan-Shen Shan, Ying-Jui Chao, Ting-Kai Liao, I-Shu Chen, Hsuan-Yi Huang, I-Ting Liu and Chia-Jui Yen

    Citation: BMC Cancer 2021 21:796

    Content type: Research

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  5. Trastuzumab emtansine (T-DM1) is a second-line standard therapy for patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer. Evidence regarding post–T-DM1 treatments is ...

    Authors: Takahiro Nakayama, Tetsuhiro Yoshinami, Hiroyuki Yasojima, Nobuyoshi Kittaka, Masato Takahashi, Shoichiro Ohtani, Seung Jin Kim, Hiroyuki Kurakami, Naoko Yamamoto, Tomomi Yamada, Takehiko Takata and Norikazu Masuda

    Citation: BMC Cancer 2021 21:795

    Content type: Research

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  7. The evolving nature of multiple myeloma (MM) therapies, including the introduction of novel oral agents, has produced a shift in the delivery of care from hospital to home. Within this context, patients and th...

    Authors: Cheryl Pritlove, Mobin Jassi, Bridget Burns and Arleigh McCurdy

    Citation: BMC Cancer 2021 21:793

    Content type: Research article

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  8. The effects of adjuvant chemotherapy in patients with stage II colorectal cancer (CRC) has been in controversy for a long time. Our study aimed to find an effective inflammatory marker to predict the effects o...

    Authors: Yu Fu, Xiaowan Chen, Yongxi Song, Xuanzhang Huang, Quan Chen, Xinger Lv, Peng Gao and Zhenning Wang

    Citation: BMC Cancer 2021 21:792

    Content type: Research article

    Published on:

  9. Liver cancer is the sixth most commonly diagnosed cancer and the fourth most common cause of cancer death. The purpose of this work is to find new diagnostic biomarkers or prognostic biomarkers and explore the...

    Authors: Shiyong Gao, Jian Gang, Miao Yu, Guosong Xin and Huixin Tan

    Citation: BMC Cancer 2021 21:791

    Content type: Research article

    Published on:

  10. Currently it is unclear how in situ breast cancer progresses to invasive disease; therefore, a better understanding of the events that occur during the transition to invasive carcinoma is warranted. Here we ha...

    Authors: Julia Samson, Magdalina Derlipanska, Oza Zaheed and Kellie Dean

    Citation: BMC Cancer 2021 21:790

    Content type: Research article

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  11. Despite the introduction of targeted therapies, most patients with myeloid malignancies will not be cured and progress. Genomics is useful to elucidate the mutational landscape but remains limited in the predi...

    Authors: Mahmoud Hallal, Sophie Braga-Lagache, Jovana Jankovic, Cedric Simillion, Rémy Bruggmann, Anne-Christine Uldry, Ramanjaneyulu Allam, Manfred Heller and Nicolas Bonadies

    Citation: BMC Cancer 2021 21:789

    Content type: Technical advance

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  12. The purpose of this study was to analyze the association between next-generation sequencing (NGS) genotypic profiles and conventional clinicopathologic characteristics in patients with acute myeloid leukemia (...

    Authors: Biao Wang, Bin Yang, Wei Wu, Xuan Liu and Haiqian Li

    Citation: BMC Cancer 2021 21:788

    Content type: Research article

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  13. Chest wall abnormalities are a poorly studied complication after treatment for childhood cancer. Chest wall abnormalities are not well-described in the literature, and little is known on the impact on daily li...

    Authors: Rahel Kasteler, Christa Lichtensteiger, Christina Schindera, Marc Ansari and Claudia E. Kuehni

    Citation: BMC Cancer 2021 21:787

    Content type: Research article

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  14. The clinical pathologic stages (stage I, II, III-IV) of hepatocellular carcinoma (HCC) are closely linked to the clinical prognosis of patients. This study aims at investigating the gene expression and mutatio...

    Authors: Xingjie Gao, Chunyan Zhao, Nan Zhang, Xiaoteng Cui, Yuanyuan Ren, Chao Su, Shaoyuan Wu, Zhi Yao and Jie Yang

    Citation: BMC Cancer 2021 21:786

    Content type: Research

    Published on:

  15. There are no epidemiological studies describing rare cancers in Western Australia (WA). We aimed to fill this gap by estimating the incidence and five-year survival of rare, less common and common cancers in W...

    Authors: Gemma A. Bilkey, Richard W. Trevithick, Emily P. Coles, Jennifer Girschik and Kristen J. Nowak

    Citation: BMC Cancer 2021 21:779

    Content type: Research

    Published on:

  16. Irreversible electroporation (IRE) is a local ablation technique utilizing high voltage, low energy direct current to create nanopores in cell membrane which disrupt homeostasis and leads to cell death. Previo...

    Authors: Govindarajan Narayanan, Malcolm M. Bilimoria, Peter J. Hosein, Zhaohui Su, Kathleen M. Mortimer and Robert C. G. Martin II

    Citation: BMC Cancer 2021 21:785

    Content type: Study protocol

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  17. Minichromosome maintenance complex component 6 (MCM6), as an important replication permission factor, is involved in the pathogenesis of various tumors. Here we studied the expression of MCM6 in neuroblastoma ...

    Authors: Yaoyao Gu, Xiaoxiao Hu, Xiaowei Liu, Cheng Cheng, Kai Chen, Yeming Wu and Zhixiang Wu

    Citation: BMC Cancer 2021 21:784

    Content type: Research article

    Published on:

  18. Lung cancer is one of the dominant causes of cancer-related deaths worldwide. Ferroptosis, an iron-dependent form of programmed cell death, plays a key role in cancer immunotherapy. However, the role of immuni...

    Authors: Taisheng Liu, Honglian Luo, Jinye Zhang, Xiaoshan Hu and Jian Zhang

    Citation: BMC Cancer 2021 21:783

    Content type: Research article

    Published on:

  19. Accumulated studies indicate that aberrant expression of long noncoding RNAs (lncRNAs) is associated with tumorigenesis and progression of colon cancer. In the present study, long intergenic non-protein coding...

    Authors: Dazhi Fu, Yongjun Ren, Chunxiao Wang, Lei Yu and Rui Yu

    Citation: BMC Cancer 2021 21:782

    Content type: Research article

    Published on:

  21. Hepatic metastases occur frequently in the context of many tumor entities. Patients with colorectal carcinoma have already developed liver metastases in 20% at the time of diagnosis, and 25–50% develop metasta...

    Authors: Theresa Voglhuber, Kerstin A. Eitz, Markus Oechsner, Marco M. E. Vogel and Stephanie E. Combs

    Citation: BMC Cancer 2021 21:780

    Content type: Research

    Published on:

  23. The overwhelming majority of dose-escalation clinical trials use methods that seek a maximum tolerable dose, including rule-based methods like the 3+3, and model-based methods like CRM and EWOC. These methods ...

    Authors: Kristian Brock, Victoria Homer, Gurjinder Soul, Claire Potter, Cody Chiuzan and Shing Lee

    Citation: BMC Cancer 2021 21:777

    Content type: Research article

    Published on:

  24. The incidence of anal squamous cell carcinoma has been increasing, particularly in people living with HIV (PLWH). There is concern that radiosensitizing drugs, such as protease inhibitors, commonly used in the...

    Authors: Alison K. Yoder, David S. Lakomy, Yongquan Dong, Suchismita Raychaudhury, Kathryn Royse, Christine Hartman, Peter Richardson, Donna L. White, Jennifer R. Kramer, Lilie L. Lin and Elizabeth Chiao

    Citation: BMC Cancer 2021 21:776

    Content type: Research article

    Published on:

  25. Few biomarkers can predict the efficiency of PD-1 blockade in patients with hepatocellular carcinoma (HCC). This study aimed to investigate the prognostic role of AFP and PIVKA-II in HCC patients receiving ant...

    Authors: Xuqi Sun, Jie Mei, Wenping Lin, Ziliang Yang, Wei Peng, Jinbin Chen, Yaojun Zhang, Li Xu and Minshan Chen

    Citation: BMC Cancer 2021 21:775

    Content type: Research

    Published on:

  26. For stage I to II high-risk endometrioid adenocarcinoma patients, the optimal adjuvant radiotherapy modality remains controversial. The present study sought to optimize the treatment of pelvic external beam ra...

    Authors: Wenhui Wang, Lijuan Zou, Tiejun Wang, Zi Liu, Jianli He, Xiaoge Sun, Wei Zhong, Fengju Zhao, Xiaomei Li, Sha Li, Hong Zhu, Zhanshu Ma, Shuai Sun, Meng Jin, Fuquan Zhang, Xiaorong Hou…

    Citation: BMC Cancer 2021 21:774

    Content type: Research

    Published on:

  27. Synovial sarcoma is an aggressive but chemosensitive soft-tissue tumor. We retrospectively analyzed the efficacy of perioperative chemotherapy for synovial sarcoma with data from the nationwide database, Bone ...

    Authors: Gang Xu, Hisaki Aiba, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Yoshihiro Araki, Shiro Saito, Kenichi Yoshimura, Hideki Murakami, Hiroyuki Tsuchiya and Akira Kawai

    Citation: BMC Cancer 2021 21:773

    Content type: Research article

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  28. Epidermal growth factor-like domain 7 (Egfl7), a recently identified secreted protein, was significantly increased in patients with HCC by our previous studies. However, its efficacy in the diagnosis of early ...

    Authors: Meng-Yuan Yang, Fan Wu, Feng Fang, Hao Yang, Jing-Fan Zhang, Guo-Dong Chen and Lian-Yue Yang

    Citation: BMC Cancer 2021 21:772

    Content type: Research

    Published on:

  29. Due to negative results in clinical trials of postoperative chemoradiation for gastric cancer, at present, there is a tendency to move chemoradiation therapy forward in gastric and gastroesophageal junction (G...

    Authors: Yu-Jie Zhou, Xiao-Fan Lu, Jia-Lin Meng, Xin-Yuan Wang, Qing-Wei Zhang, Jin-Nan Chen, Qi-Wen Wang, Fang-Rong Yan and Xiao-Bo Li

    Citation: BMC Cancer 2021 21:771

    Content type: Research article

    Published on:

  30. Various studies investigating the clinical significance of FBXW7 mutation and/or expression have yielded inconclusive results in colorectal cancer (CRC) patients. Therefore, the present meta-analysis summarize...

    Authors: Wei Shang, Chuanwang Yan, Ran Liu, Lili Chen, Dongdong Cheng, Liang Hao, Wenguang Yuan, Jingbo Chen and Hui Yang

    Citation: BMC Cancer 2021 21:770

    Content type: Research article

    Published on:

  32. The heterogeneous subtypes and stages of epithelial ovarian cancer (EOC) differ in their biological features, invasiveness, and response to chemotherapy, but the transcriptional regulators causing their differ...

    Authors: Yichao Li, Sushil K. Jaiswal, Rupleen Kaur, Dana Alsaadi, Xiaoyu Liang, Frank Drews, Julie A. DeLoia, Thomas Krivak, Hanna M. Petrykowska, Valer Gotea, Lonnie Welch and Laura Elnitski

    Citation: BMC Cancer 2021 21:768

    Content type: Research

    Published on:

  33. The change of immune cell infiltration essentially influences the process of colorectal cancer development. The infiltration of immune cells can be regulated by a variety of genes. Thus, modeling the immune mi...

    Authors: Shaokun Wang, Li Pang, Zuolong Liu and Xiangwei Meng

    Citation: BMC Cancer 2021 21:767

    Content type: Research

    Published on:

  34. The surgical management and outcomes of renal cell carcinoma (RCC) with venous tumor thrombus (VTT) have been reported in limited sample size, and there remain discrepancies over the factors that influence onc...

    Authors: Zhigang Chen, Feilong Yang, Liyuan Ge, Min Qiu, Zhuo Liu, Cheng Liu, Xiaojun Tian, Shudong Zhang and Lulin Ma

    Citation: BMC Cancer 2021 21:766

    Content type: Research article

    Published on:

  35. The formation of blood vessels within solid tumors directly contributes to cancer growth and metastasis. Until recently, tumor vasculature was thought to occur exclusively via endothelial cell (EC) lined struc...

    Authors: Carmela Martini, Mark DeNichilo, Danielle P. King, Michaelia P. Cockshell, Brenton Ebert, Brian Dale, Lisa M. Ebert, Anthony Woods and Claudine S. Bonder

    Citation: BMC Cancer 2021 21:765

    Content type: Research article

    Published on:

  36. Cement leakage into venous blood posed significant challenge to surgeons. The aim of the study was to create a Peking University First Hospital Score (PUFHS) which could evaluate the probability of vascular ce...

    Authors: Xuedong Shi, Yunpeng Cui, Yuanxing Pan, Bing Wang and Mingxing Lei

    Citation: BMC Cancer 2021 21:764

    Content type: Research

    Published on:

  37. Algorithms that use administrative health and electronic medical record (EMR) data to determine cancer recurrence have the potential to replace chart reviews. This study evaluated algorithms to determine breas...

    Authors: Pascal Lambert, Marshall Pitz, Harminder Singh and Kathleen Decker

    Citation: BMC Cancer 2021 21:763

    Content type: Research article

    Published on:

  38. Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy that most commonly affects the pleural layers. MPM has a strong association with asbestos, mainly caused by exposure to its biopersisten...

    Authors: Laura Saracino, Chandra Bortolotto, Stefano Tomaselli, Elia Fraolini, Matteo Bosio, Giulia Accordino, Francesco Agustoni, David M. Abbott, Emma Pozzi, Dimitrios Eleftheriou, Patrizia Morbini, Pietro Rinaldi, Cristiano Primiceri, Andrea Lancia, Patrizia Comoli, Andrea R. Filippi…

    Citation: BMC Cancer 2021 21:762

    Content type: Research article

    Published on:

  39. Immunotherapy is revolutionising the treatment of patients diagnosed with melanoma and other cancers. The first immune checkpoint inhibitor, ipilimumab (targeting cytotoxic T-lymphocyte-associated antigen 4 (C...

    Authors: Oliver Coen, Pippa Corrie, Helen Marshall, Ruth Plummer, Christian Ottensmeier, Jane Hook, Sue Bell, Gurdeep S. Sagoo, David Meads, Janine Bestall, Galina Velikova, Ferdia A. Gallagher, Alexandra Smith, Helen Howard, Ellen Mason, Eszter Katona…

    Citation: BMC Cancer 2021 21:761

    Content type: Study protocol

    Published on:

  40. Breast cancer is the leading cause of cancer-related deaths in females worldwide. Formin-like protein 2 (FMNL2) is a member of formin family that governs cytokinesis, cell polarity, morphogenesis and cell divi...

    Authors: Xinyan Jiao, Bo Wang, Chen Feng, Shaoran Song, Bixia Tian, Can Zhou, Xiaoqian Gao, Wei Sun and Peijun Liu

    Citation: BMC Cancer 2021 21:760

    Content type: Research article

    Published on:

  41. The Swedish healthcare is decentralised to 21 regions. Detailed information on all delivered care in the southernmost region, Skåne, is prospectively collected in the Skåne Healthcare Register (SHR). The data ...

    Authors: Qing Shen, Maria E. C. Schelin, Fang Fang and Anna Jöud

    Citation: BMC Cancer 2021 21:759

    Content type: Research article

    Published on:

  42. Eribulin mesylate (ERI; Halaven®) is a microtubule inhibitor approved in the United States for metastatic breast cancer patients with at least two prior chemotherapy regimens for metastatic breast cancer, and ...

    Authors: Qi Zhao, Rachel Hughes, Binod Neupane, Kristin Mickle, Yun Su, Isabelle Chabot, Marissa Betts and Ananth Kadambi

    Citation: BMC Cancer 2021 21:758

    Content type: Research article

    Published on:

  43. International differences in survival among colorectal cancer (CRC) patients may partly be explained by differences in emergency presentations (EP), waiting times and access to treatment.

    Authors: Yngvar Nilssen, Morten Tandberg Eriksen, Marianne G. Guren and Bjørn Møller

    Citation: BMC Cancer 2021 21:757

    Content type: Research

    Published on:

  44. Chemotherapy regimens that include the utilization of gemcitabine are the standard of care in pancreatic cancer patients. However, most patients with advanced pancreatic cancer die within the first 2 years aft...

    Authors: Patrick Innamarato, Jennifer Morse, Amy Mackay, Sarah Asby, Matthew Beatty, Jamie Blauvelt, Scott Kidd, John E. Mullinax, Amod A. Sarnaik and Shari Pilon-Thomas

    Citation: BMC Cancer 2021 21:756

    Content type: Research

    Published on:

  45. Almost all Koreans are covered by mandatory national health insurance and are required to undergo health screening at least once every 2 years. We aimed to develop a machine learning model to predict the risk ...

    Authors: Chansik An, Jong Won Choi, Hyung Soon Lee, Hyunsun Lim, Seok Jong Ryu, Jung Hyun Chang and Hyun Cheol Oh

    Citation: BMC Cancer 2021 21:755

    Content type: Research

    Published on:

  46. As a marker of differentiation, Killer cell lectin like receptor G1 (KLRG1) plays an inhibitory role in human NK cells and T cells. However, its clinical role remains inexplicit. This work intended to investig...

    Authors: Xiaodong Yang, Yuexin Zheng, Zhihai Han and Xiliang Zhang

    Citation: BMC Cancer 2021 21:752

    Content type: Research article

    Published on:

  47. Radiofrequency ablation (RFA) is an effective treatment option for hepatocellular carcinoma (HCC). This study aimed to analyze the prognostic factors of HCC patients treated with RFA and to develop nomograms f...

    Authors: Zhenhua Lu, Zhen Sun, Chengyu Liu, Xiaolei Shi, Rui Li, Weiwei Shao, Yangyang Zheng, Yao Li and Jinghai Song

    Citation: BMC Cancer 2021 21:751

    Content type: Research article

    Published on:

  48. Tumor microenvironment (TME) critically contributed to the malignant progression of transformed cells and the chemical responses to chemotherapy reagents. Osteopontin (OPN) is a secretory onco-protein with sev...

    Authors: Jing Huang, Mu Hu, Huan Niu, Jing Wang, Yang Si, Shan Cheng and Wei Ding

    Citation: BMC Cancer 2021 21:750

    Content type: Research

    Published on:

  49. The molecular pathogenesis of endometrial cancer is not completely understood. CypB upregulated in many cancers, however, its role in endometrial carcinoma has not been studied. Here, we determine the effect o...

    Authors: Jing Liu, Ying Zuo, Gui-Mei Qu, Xiao Song, Zhong-Hui Liu, Ting-Guo Zhang, Zhu-Hua Zheng and Hong-Kun Wang

    Citation: BMC Cancer 2021 21:747

    Content type: Research article

    Published on:

  50. Considerable evidence has indicated an association between the immune microenvironment and clinical outcome in ccRCC. The purpose of this study is to extensively figure out the influence of immune-related gene...

    Authors: Guangyao Li, Xiyi Wei, Shifeng Su, Shangqian Wang, Wei Wang, Yichun Wang, Xianghu Meng, Jiadong Xia, Ninghong Song and Chao Qin

    Citation: BMC Cancer 2021 21:746

    Content type: Research article

    Published on:

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