This study assessed the health related quality of life of family caregivers (FCs) of leukemia patients by using the health utility scores derived from the EuroQol five-dimensional (EQ-5D) questionnaire.
Authors: Hongjuan Yu, Huan Zhang, Jinjin Yang, Chaojie Liu, Chengfang Lu, Hongbin Yang, Weidong Huang, Jin Zhou, Wenqi Fu, Linmei Shi, Yan Yan, Guoxiang Liu and Limin Li
Epithelial ovarian cancer is a common malignancy, with no clinically approved diagnostic biomarker. Engrailed-2 (EN2) is a homeodomain-containing transcription factor, essential during embryological neural dev...
Authors: Sophie Elena McGrath, Nicola Annels, Thumuluru K. Madhuri, Anil Tailor, Simon A. Butler-Manuel, Richard Morgan, Hardev Pandha and Agnieszka Michael
The safety of laparoscopic total gastrectomy (LTG) for the treatment of gastric cancer remains lack of clinical evidence. The Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group recently launched...
The analysis of tumour-infiltrating immune cells within patients’ tumour samples in colorectal cancer (CRC) has become an independent predictor of patient survival. The tumour microenvironment and the immune c...
Authors: Ramón Cantero-Cid, José Casas-Martin, Enrique Hernández-Jiménez, Carolina Cubillos-Zapata, Aníbal Varela-Serrano, José Avendaño-Ortiz, Marta Casarrubios, Karla Montalbán-Hernández, Ignacio Villacañas-Gil, Laura Guerra-Pastrián, Begoña Peinado, Cristóbal Marcano, Luis A Aguirre and Eduardo López-Collazo
Survival of esophageal cancer in Linzhou was seen to increase over the past few decades and is higher than the average level of China due to the implementation of comprehensive prevention and control measures....
Authors: Shuzheng Liu, Lanwei Guo, Qiong Chen, Liang Yu, Bianyun Li, Xiaoqin Cao and Xibin Sun
The rs2147578 C > G polymorphism in the long non-coding RNA gene Lnc-LAMC2–1:1 is associated with increased susceptibility to a few types of cancers. However, its role in neuroblastoma has not been evaluated yet.
Authors: Tianyou Yang, Zhuorong Zhang, Jiao Zhang, Tianbao Tan, Jiliang Yang, Jing Pan, Chao Hu, Jiahao Li, Huimin Xia, Jing He and Yan Zou
Immune checkpoint inhibitors (ICIs) have emerged as promising therapeutic agents in non-small cell lung cancer (NSCLC). However, the duration for which ICIs should be continued remains a clinical problem.
Chronic active Epstein-Barr virus (EBV) infection (CAEBV) of the T-/NK-cell type, systemic form is a rare and potentially life-threatening illness caused by persistent EBV infection. The highest incidence is f...
Authors: Maxi Wass, Marcus Bauer, Roald Pfannes, Kerstin Lorenz, Andreas Odparlik, Lutz P Müller and Claudia Wickenhauser
Coagulation and nutrition play important roles in cancer progression. The aim of the present study is to evaluate the prognostic value of the preoperative fibrinogen/albumin ratio (FAR) in surgical patients wi...
Authors: Yao Liang, Wei Wang, Yi Que, Yuanxiang Guan, Wei Xiao, Cheng Fang, Xing Zhang and Zhiwei Zhou
Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting p...
Authors: András Folyovich, Viktória Varga, György Várallyay, Lajos Kozák, Mária Bakos, Erika Scheidl, Katalin Anna Béres-Molnár, Zita Kajdácsi and Dániel Bereczki
Clonal VDJ rearrangement of B/T cell receptors (B/TCRs) occurring during B/T lymphocyte development has been used as a marker to track the clonality of B/T cell populations.
Authors: Kar-Tong Tan, Ling-Wen Ding, Qiao-Yang Sun, Zhen-Tang Lao, Wenwen Chien, Xi Ren, Jin-Fen Xiao, Xin Yi Loh, Liang Xu, Michael Lill, Anand Mayakonda, De-Chen Lin, Henry Yang and H. Phillip Koeffler
In many types of solid tumours, the aberrant expression of the cell adhesion molecule N-cadherin is a hallmark of epithelial-to-mesenchymal transition, resulting in the acquisition of an aggressive tumour phen...
Authors: Krzysztof Marek Mrozik, Orest William Blaschuk, Chee Man Cheong, Andrew Christopher William Zannettino and Kate Vandyke
Carcinogenesis and tumor growth are associated with chronic inflammation and the host immune system. Here, we investigated the clinical significance and relationship between tumor-infiltrating lymphocytes (TIL...
Authors: Kwan Ho Lee, Eun Young Kim, Ji Sup Yun, Yong Lai Park, Sung-Im Do, Seoung Wan Chae and Chan Heun Park
The tyrosine kinase inhibitor pazopanib is used for treatment of sarcoma. Recent studies have suggested that the use of pazopanib may lead to the development of pneumothorax, an unexpected adverse effect in pa...
Authors: Bruce Sabath, Hasan A Muhammad, Amulya Balagani, David E Ost, Erik Vakil, Tahreem Ahmed, Macarena R Vial and Horiana B Grosu
Breast cancer related lymphoedema (BCRL) occurs in a substantial proportion of breast cancer survivors and is a major contributor to patients’ disability. Regrettably, there are no validated predictive biomark...
Authors: Marco Invernizzi, Chiara Corti, Gianluca Lopez, Anna Michelotti, Luca Despini, Donatella Gambini, Daniele Lorenzini, Elena Guerini-Rocco, Stefania Maggi, Marianna Noale and Nicola Fusco
Cancer research has made great progress in the recent years. With the increasing number of options in diagnosis and therapy the implementation of tumorboards (TUBs) has become standard procedure in the treatme...
Authors: S. Hollunder, U. Herrlinger, M. Zipfel, J. Schmolders, V. Janzen, T. Thiesler, E. Güresir, A. Schröck, F. Far, T. Pietsch, D. Pantelis, D. Thomas, S. Vornholt, N. Ernstmann, T. Manser, M. Neumann…
Several trials evaluated the role of ovarian function suppression for the adjuvant treatment of premenopausal patients with hormone receptor-positive early breast cancer. Based on the results of the SOFT and T...
Authors: Giacomo Pelizzari, Grazia Arpino, Laura Biganzoli, Saverio Cinieri, Michelino De Laurentiis, Lucia Del Mastro, Angelo Di Leo, Stefania Gori, Valentina Guarneri, Paolo Marchetti and Fabio Puglisi
Organizations that issue guidance on breast cancer recommend the use of immunohistochemistry (IHC) for providing appropriate and precise care. However, little focus has been directed to the identification of m...
Authors: Arturo López-Pineda, Mario F Rodríguez-Moran, Cleto Álvarez-Aguilar, Sarah M Fuentes Valle, Román Acosta-Rosales, Ami S Bhatt, Shruti N Sheth and Carlos D Bustamante
Several intervention studies have demonstrated that exercise training has beneficial effects among cancer patients. However, older cancer patients are underrepresented in clinical trials, and only few exercise...
Authors: Marta Kramer Mikkelsen, Cecilia Margareta Lund, Anders Vinther, Anders Tolver, Anne-Mette Ragle, Julia Sidenius Johansen, Inna Chen, Lotte Engell-Noerregaard, Finn Ole Larsen, Bo Zerahn, Dorte Lisbet Nielsen and Mary Jarden
Initial primary colorectal cancer (IPCRC) has a high risk of developing into second primary colorectal cancer (SPCRC). Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) have different characteri...
Authors: Lin Yang, Zhenchong Xiong, Qian Kun Xie, Wenzhuo He, Shousheng Liu, Pengfei Kong, Chang Jiang, Xiaojun Xia and Liangping Xia
Greater family size measured with total fertility rate (TFR) and with household size, may offer more life satisfaction to the family members. Positive psychological well-being has been postulated to decrease c...
Authors: Wenpeng You, Frank J Rühli, Renata J Henneberg and Maciej Henneberg
There is a pressing need to reduce the burden of chronic disease and improve healthcare system sustainability through improved cancer and chronic disease prevention and screening (CCDPS) in primary care. We ai...
Authors: Donna Patricia Manca, Carolina Fernandes, Eva Grunfeld, Kris Aubrey-Bassler, Melissa Shea-Budgell, Aisha Lofters, Denise Campbell-Scherer, Nicolette Sopcak, Mary Ann O’Brien, Christopher Meaney, Rahim Moineddin, Kerry McBrien, Ginetta Salvalaggio and Paul Krueger
Improved risk stratification, more effective therapy and better supportive care have resulted in survival rates after childhood cancer of around 80% in developed countries. Treatment however can be harsh, and ...
Authors: Anne-Lotte L. F. van der Kooi, Eva Clemens, Linda Broer, Oliver Zolk, Julianne Byrne, Helen Campbell, Marleen van den Berg, Claire Berger, Gabriele Calaminus, Uta Dirksen, Jeanette Falck Winther, Sophie D Fosså, Desiree Grabow, Riccardo Haupt, Melanie Kaiser, Tomas Kepak…
Cancer stem cells (CSC) are characterized by deregulated self-renewal, tumorigenicity, metastatic potential, aberrant stemness signaling pathways, resistance to conventional therapy, and the ability to give ri...
Authors: Gabriele Davide Bigoni-Ordóñez, Elizabeth Ortiz-Sánchez, Pedro Rosendo-Chalma, Heriberto A Valencia-González, Carmen Aceves and Alejandro García-Carrancá
Chimeric antigen receptor T (CAR T) cells immunotherapy is rapidly developed in treating cancers, especially relapsed or refractory B-cell malignancies.
Authors: Hui Zhou, Yuling Luo, Sha Zhu, Xi Wang, Yunuo Zhao, Xuejin Ou, Tao Zhang and Xuelei Ma
Breast cancer is the most common cancer in women. 12–15% of all tumors are triple-negative breast cancers (TNBC). So far, TNBC has been mainly associated with mutations in BRCA1. The presence of other predispo...
Authors: Juliane Hoyer, Georgia Vasileiou, Steffen Uebe, Marius Wunderle, Cornelia Kraus, Peter A. Fasching, Christian T. Thiel, Arndt Hartmann, Matthias W. Beckmann, Michael P. Lux and André Reis
Cervical cancer incidence and mortality is high in Uyghur ethnics. Their life style and dietary habit were different from other ethnics living together. Study on the role of trace elements in HPV infection and...
PRKAA1 encodes α-subunit of 5-AMP-activated protein kinase (AMPK), which has been implicated in the pathogenesis of carcinoma of the stomach. Previous works have suggested that polymorphisms in the PRKAA1 may be ...
Authors: Minbin Chen, Baohu Jiang, Bangshun He, Min Tang, Ping Wang, Li Chen, Jianwei Lu and Peihua Lu
Protein kinase inhibitors (PKIs) are currently tested in clinical studies (phase I-III) as an alternative strategy against (recurrent) ovarian cancer. Besides their anti-tumour efficacy, several PKIs have also...
Authors: Dennis Lindenblatt, Nastassja Terraneo, Giovanni Pellegrini, Susan Cohrs, Philipp René Spycher, David Vukovic, Martin Béhé, Roger Schibli and Jürgen Grünberg
Hospitalized cancer patients undergoing intensive or high-dose chemotherapy often experience a considerable decline in functional performance associated with the increased risk of adverse health events. Exerci...
Authors: Antonia Pahl, Anja Wehrle, Sarah Kneis, Albert Gollhofer and Hartmut Bertz
Perianal Paget’s disease (PPD) is a rare intraepithelial adenocarcinoma of the anal margin. Primary PPD likely represents intra-epithelial neoplasm from an apocrine source, whereas secondary disease may repres...
Authors: Jéssica Silva dos Santos, Gabriel Alves Bonafé, José Aires Pereira, Danilo Toshio Kanno, Carlos Augusto Real Martinez and Manoela Marques Ortega
Patients undergoing chemotherapy are highly burdened by side effects. These may be caused by the pharmacodynamics of the drug or be driven by psychological factors such as negative expectations or pre-conditio...
Authors: Julia Quidde, Yiqi Pan, Melanie Salm, Armin Hendi, Sven Nilsson, Karin Oechsle, Alexander Stein and Yvonne Nestoriuc
Immunochemical fecal occult blood tests (iFOBTs) are increasingly used for colorectal cancer (CRC) screening. In our preceding observational study, sensitivity for detecting advanced colorectal neoplasms by iF...
Authors: Kaja Tikk, David Czock, Walter E. Haefeli, Annette Kopp-Schneider and Hermann Brenner
Total P16 methylation (P16M), including P16 hydroxymethylation (P16H) and true-P16M, correlates with malignant transformation of oral epithelial dysplasia (OED). Both true-P16M and P16H are early events in carcin...
Authors: Hongwei Liu, Zhaojun Liu, Xue-wei Liu, Si Xu, Lei Wang, Yang Liu, Jing Zhou, Liankun Gu, Yan Gao, Xiao-yong Liu, Huidong Shi, Zheng Sun and Dajun Deng
Biannual ultrasound (US)—with or without alpha-fetoprotein (AFP)—is recommended by current guidelines for the surveillance of hepatocellular carcinoma (HCC). However, the inadequate sensitivity of US has been ...
Authors: Chansik An, Do Young Kim, Jin-Young Choi, Kwang Hyub Han, Yun Ho Roh and Myeong-Jin Kim
Hepatocellular carcinoma (HCC) is a common malignant tumor with high fatality rate. Recent studies reported that up-regulation of long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) w...
Authors: Deyu Huang, Chunhua Bi, Qingxi Zhao, Xueli Ding, Cheng Bian, Hui Wang, Ting Wang and Hua Liu
Soft tissue sarcomas are a heterogeneous and rare group of solid tumors of mesenchymal origin that can arise anywhere in the body. Although surgical resection is the mainstay of treatment for patients with loc...
Authors: Emily Z. Keung, Alexander J. Lazar, Keila E. Torres, Wei-Lien Wang, Janice N. Cormier, B. Ashleigh Guadagnolo, Andrew J. Bishop, Heather Lin, Kelly K. Hunt, Justin Bird, Valerae O. Lewis, Shreyaskumar R. Patel, Jennifer A. Wargo, Neeta Somaiah and Christina L. Roland
Febrile neutropenia (FN) is a common occurrence during chemotherapy. Granulocyte colony-stimulating factors (G-CSFs) can significantly reduce the risk of FN. International guidelines recommend G-CSF for patien...
Authors: Bernardo Leon Rapoport, Matti Aapro, Marianne Paesmans, Ronwyn van Eeden, Teresa Smit, Andriy Krendyukov and Jean Klastersky
Traditional therapeutics have encountered a bottleneck caused by diagnosis delay and subjective and unreliable assessment. Biomarkers can overcome this bottleneck and guide us toward personalized precision med...
Authors: Liang Zhong, Yutong Liu, Kai Wang, Zhijing He, Zhaojian Gong, Zhili Zhao, Yaocheng Yang, Xiaofei Gao, Fangjie Li, Hanjiang Wu, Sheng Zhang and Lin Chen
The combination of chemotherapy and L-asparaginase (L-ASP) treatment significantly increased survival rate in an adult patient with extranodal natural killer (NK)/T-cell lymphoma (NKTCL). However, hypersensitivit...
Women diagnosed with gynaecological cancer experience supportive care needs that require care provision to reduce the impact on their lives. International evidence suggests supportive care needs of women with ...
Authors: Natalie Williams, Georgia Griffin, Victoria Farrell, Alethea Rea, Kevin Murray and Yvonne L. Hauck
The treatment recommendations for Low-grade Gliomas (LGG) underwent profound changes due to results from RTOG 9802 published in April 2016. This work aims to investigate whether the results from the trial were...
Authors: Christoph Straube, Kerstin A. Kessel, Friederike Schmidt-Graf, Sandro M. Krieg, Bernhard Meyer, Jens Gempt and Stephanie E. Combs
This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC).
Authors: Ruo-Xi Wang, Sheng Chen, Liang Huang and Zhi-Ming Shao
Although there has been marked development in surgical techniques, there is no easy and fast method of predicting complications in minimally invasive surgeries. We evaluated whether the modified surgical Apgar...
Authors: Seon Hee Park, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim
Colorectal cancer (CRC) is an illness strongly influenced by sex and gender, with mortality rates in males significantly higher than females. There is still a dearth of understanding on where sex differences e...
Authors: Alan White, Lucy Ironmonger, Robert J. C. Steele, Nick Ormiston-Smith, Carina Crawford and Amanda Seims
There is an urgent need for more novel and efficacious therapeutic agents and strategies for the treatment of ovarian cancer - one of the most formidable female malignancies. These approaches should be based o...
Authors: Vsevolod I. Kiselev, Levon A. Ashrafyan, Ekaterina L. Muyzhnek, Evgeniya V. Gerfanova, Irina B. Antonova, Olga I. Aleshikova and Fazlul H. Sarkar
Endometriosis is a relatively common condition in women of reproductive age. Malignant transformation of intestinal endometriosis is a very rare event. We report a case in which a patient with a history of end...
Authors: Ningning Li, Weixun Zhou, Lin Zhao and Jiaolin Zhou
Magnetic resonance imaging (MRI) has improved capacity to visualize tumor and soft tissue involvement in head and neck cancers. Using advanced MRI, we can interrogate cell density using diffusion weighted imag...
Authors: Sweet Ping Ng, Houda Bahig, Jihong Wang, Carlos E. Cardenas, Anthony Lucci, Carolyn S. Hall, Salyna Meas, Vanessa N. Sarli, Ying Yuan, Diana L. Urbauer, Yao Ding, Shane Ikner, Vi Dinh, Baher A. Elgohari, Jason M. Johnson, Heath D. Skinner…
Accelerated malignant behaviors induced by insufficient thermal ablation have been increasingly reported, however, the exact mechanisms are still unclear. Here, we investigated the importance of the extracellu...
Authors: Rui Zhang, Min Ma, Xia-Hui Lin, Hua-Hua Liu, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren and Rong-Xin Chen
