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  1. In patients undergoing major liver resection, portal vein embolization (PVE) has been widely used to induce hypertrophy of the non-embolized liver in order to prevent post-hepatectomy liver failure. PVE is a s...

    Authors: Emmanuel Deshayes, Lauranne Piron, Antoine Bouvier, Bruno Lapuyade, Emilie Lermite, Laurent Vervueren, Christophe Laurent, Jean-Baptiste Pinaquy, Patrick Chevallier, Anthony Dohan, Agnès Rode, Christian Sengel, Chloé Guillot, François Quenet and Boris Guiu

    Citation: BMC Cancer 2020 20:574

    Content type: Study protocol

    Published on:

  2. This study aims to determine the real incidence of pericolic lymph nodes metastasis beyond 10 cm proximal to the tumor (pPCN) and its prognostic significance in rectal cancer patients.

    Authors: Xuyang Yang, Erliang Zheng, Lina Ye, Chaoyang Gu, Tao Hu, Dan Jiang, Du He, Bing Wu, Qinbing Wu, Tinghan Yang, Mingtian Wei, Wenjian Meng, Xiangbing Deng, Ziqiang Wang and Zongguang Zhou

    Citation: BMC Cancer 2020 20:573

    Content type: Research article

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  3. Despite recent advances in cancer immunotherapy, the efficacy of these therapies for the treatment of human prostate cancer patients is low due to the complex immune evasion mechanisms (IEMs) of prostate cance...

    Authors: Mayassa J. Bou-Dargham, Linlin Sha, Qing-Xiang Amy Sang and Jinfeng Zhang

    Citation: BMC Cancer 2020 20:572

    Content type: Research article

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  4. The resistance of lung cancer to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) is one of the unconquered frontiers in chemotherapy. Mitogen-inducible gene 6 (Mig-6) is known to inhibit ...

    Authors: Da Hyun Kang, Sung Soo Jung, Min-Kyung Yeo, Da Hye Lee, Geon Yoo, Sang Yeon Cho, In-Jae Oh, Ju-Ock Kim, Hee Sun Park, Chaeuk Chung and Jeong Eun Lee

    Citation: BMC Cancer 2020 20:571

    Content type: Research article

    Published on:

  5. In principle, risk-stratification as a routine part of the NHS Breast Screening Programme (NHSBSP) should produce a better balance of benefits and harms. The main benefit is the offer of NICE-approved more fre...

    Authors: David P. French, Susan Astley, Adam R. Brentnall, Jack Cuzick, Richard Dobrashian, Stephen W. Duffy, Louise S. Gorman, Elaine F. Harkness, Fiona Harrison, Michelle Harvie, Anthony Howell, Andrew Jerrison, Matthew Machin, Anthony J. Maxwell, Lorna McWilliams, Katherine Payne…

    Citation: BMC Cancer 2020 20:570

    Content type: Study protocol

    Published on:

  6. KRAS mutations are prevalent in 40–45% of patients with colorectal cancer (CRC) and targeting this gene has remained elusive. Viruses are well known immune sensitizing agents. The therapeutic efficacy of oncolyti...

    Authors: Ruwan Parakrama, Elisha Fogel, Carol Chandy, Titto Augustine, Matt Coffey, Lydia Tesfa, Sanjay Goel and Radhashree Maitra

    Citation: BMC Cancer 2020 20:569

    Content type: Research article

    Published on:

  7. Prognostic biomarkers provide essential information about a patient’s overall outcome. However, existing biomarkers are limited in terms of either sample collection, such as requiring tissue specimens, or the ...

    Authors: Takumi Hasegawa, Tomoya Iga, Daisuke Takeda, Rika Amano, Izumi Saito, Yasumasa Kakei, Junya Kusumoto, Akira Kimoto, Akiko Sakakibara and Masaya Akashi

    Citation: BMC Cancer 2020 20:568

    Content type: Research article

    Published on:

  8. Skin cancer is the most common cancer worldwide and commonly classified into malignant melanoma (MM) and Nonmelanoma skin cancers (NMSCs), which mainly include basal cell carcinoma (BCC) and squamous cell carc...

    Authors: Mohammad Ali Zolfaghari, Abbas Karimi, Elham Kalantari, Alireza Korourian, Alireza Ghanadan, Kambiz Kamyab, Nafiseh Esmaili, Amir Nader Emami Razavi and Zahra Madjd

    Citation: BMC Cancer 2020 20:567

    Content type: Research article

    Published on:

  9. Only 10–30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and angiogenic mediators in the tumour microenvironm...

    Authors: Maria E. Morrissey, Róisín Byrne, Celina Nulty, Niamh H. McCabe, Niamh Lynam-Lennon, Clare T. Butler, Susan Kennedy, Dermot O’Toole, John Larkin, Paul McCormick, Brian Mehigan, Mary-Clare Cathcart, Joanne Lysaght, John V. Reynolds, Elizabeth J. Ryan, Margaret R. Dunne…

    Citation: BMC Cancer 2020 20:566

    Content type: Research article

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  10. It may be impossible to perform cancer surgery with free margins in the presence of an unresectable structure. Local drug treatment after surgery has been proposed to increase the rate of tumor control.

    Authors: Iman Al Dybiat, Alibi Baitukha, Cynthia Pimpie, Rachid Kaci, Marc Pocard, Farzaneh Arefi Khonsari and Massoud Mirshahi

    Citation: BMC Cancer 2020 20:565

    Content type: Research article

    Published on:

  11. Differentiation of suprasellar meningiomas (SSMs) from non-functioning pituitary macroadenomas (NFPMAs) is useful for clinical management. We investigated the utility of 13N-ammonia combined with 18F-FDG positron...

    Authors: Lei Ding, Fangling Zhang, Qiao He, Zhoulei Li, Xinchong Shi, Ruocheng Li and Xiangsong Zhang

    Citation: BMC Cancer 2020 20:564

    Content type: Research article

    Published on:

  12. Cervical cancer is the fourth most common cancer among women worldwide. Sub- Saharan Africa has a high incidence, prevalence and mortality due to shortage and underutilization of screening facilities. This stu...

    Authors: Friederike Ruddies, Muluken Gizaw, Brhanu Teka, Sarah Thies, Andreas Wienke, Andreas M. Kaufmann, Tamrat Abebe, Adamu Addissie and Eva Johanna Kantelhardt

    Citation: BMC Cancer 2020 20:563

    Content type: Research article

    Published on:

  13. The prognosis is very poor for lung cancer patients with bone metastasis. Unfortunately, a suitable method has yet to become available for the early diagnosis of bone metastasis in lung cancer patients. The pr...

    Authors: Xiaoyan Teng, Lirong Wei, Liming Han, Daliu Min and Yuzhen Du

    Citation: BMC Cancer 2020 20:562

    Content type: Research article

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  14. Racial disparities are well-documented in preventive cancer care, but they have not been fully explored in the context of lung cancer screening. We sought to explore racial differences in lung cancer screening...

    Authors: Michael Lake, Christine S. Shusted, Hee-Soon Juon, Russell K. McIntire, Charnita Zeigler-Johnson, Nathaniel R. Evans, Gregory C. Kane and Julie A. Barta

    Citation: BMC Cancer 2020 20:561

    Content type: Research article

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  15. 5-Fluorouracil (5-FU) and capecitabine are fluoropyrimidine derivatives that mainly metabolized with dihydropyrimidine dehydrogenase enzyme (DPD). The genetic polymorphism in the genes encoding this enzyme may...

    Authors: Reza Negarandeh, Ebrahim Salehifar, Fatemeh Saghafi, Hossein Jalali, Ghasem Janbabaei, Mohammad Javad Abdhaghighi and Anahita Nosrati

    Citation: BMC Cancer 2020 20:560

    Content type: Research article

    Published on:

  16. Pain self-management support interventions were effective in controlled clinical trials and meta analyses. However, implementation of these complex interventions may not translate into identical effects. This ...

    Authors: Silvia Raphaelis, Florian Frommlet, Hanna Mayer and Antje Koller

    Citation: BMC Cancer 2020 20:559

    Content type: Research article

    Published on:

  17. A prognostic model combining biomarkers of metaphase-anaphase transition of the cell cycle was developed for invasive breast cancer. The prognostic value and clinical applicability of the model was evaluated i...

    Authors: Heli Repo, Eliisa Löyttyniemi, Samu Kurki, Lila Kallio, Teijo Kuopio, Kati Talvinen and Pauliina Kronqvist

    Citation: BMC Cancer 2020 20:558

    Content type: Research article

    Published on:

  18. About 50% of non-small cell lung cancer (NSCLC) patients have metastatic disease at initial diagnosis, which limits their treatment options and, consequently, the 5-year survival rate (15%). Immune checkpoint ...

    Authors: Relinde I. Y. Lieverse, Evert J. Van Limbergen, Cary J. G. Oberije, Esther G. C. Troost, Sine R. Hadrup, Anne-Marie C. Dingemans, Lizza E. L. Hendriks, Franziska Eckert, Crispin Hiley, Christophe Dooms, Yolande Lievens, Monique C. de Jong, Johan Bussink, Xavier Geets, Vincenzo Valentini, Giuliano Elia…

    Citation: BMC Cancer 2020 20:557

    Content type: Study protocol

    Published on:

  19. Liver fibrosis or cirrhosis is associated with the dismal prognosis of hepatocellular carcinoma (HCC), and it might also be involved in intrahepatic cholangiocarcinoma (ICC). The effect of hepatic fibrosis on ...

    Authors: Jian Xi Zhang, Peipei Li, Zhibin Chen, Huogui Lin, Zhezhen Cai, Weijia Liao and Zirong Pan

    Citation: BMC Cancer 2020 20:556

    Content type: Research article

    Published on:

  20. Prostate cancer (PC), a common malignant tumor, is the second-leading cause of cancer death among American men. Its successful treatment greatly relies on the early diagnose. Engrailed-2 (EN2) has been confirm...

    Authors: Qi Li, Yibo Shi, Rigai Sa, Jun Hao, Jinhao Hu, Mulun Xiao, Chaoliang Wang, Liang Yan, Baoping Qiao and Guoxun Chen

    Citation: BMC Cancer 2020 20:555

    Content type: Research article

    Published on:

  21. Metastatic medulloblastoma (MB) portends a poor prognosis. Amongst the 4 molecular subtypes, Group 3 and Group 4 patients have a higher incidence of metastatic disease, especially involving the neuroaxis. At p...

    Authors: Sharon Y. Y. Low, Nurfahanah Bte Syed Sulaiman, Enrica E. K. Tan, Lee Ping Ng, Chik Hong Kuick, Kenneth T. E. Chang, Phua Hwee Tang, Ru Xin Wong, Wen Shen Looi, David C. Y. Low and Wan Tew Seow

    Citation: BMC Cancer 2020 20:554

    Content type: Research article

    Published on:

  22. Pediatric acute myeloid leukemia (AML) with t(8;21) (q22;q22) is classified as a low-risk group. However, relapse is still the main factor affecting survival. We aimed to investigate the effect of allogeneic h...

    Authors: Guan-hua Hu, Yi-fei Cheng, Ai-dong Lu, Yu Wang, Ying-xi Zuo, Chen-hua Yan, Jun Wu, Yu-qian Sun, Pan Suo, Yu-hong Chen, Huan Chen, Yue-ping Jia, Kai-yan Liu, Wei Han, Lan-ping Xu, Le-ping Zhang…

    Citation: BMC Cancer 2020 20:553

    Content type: Research article

    Published on:

  23. The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular ...

    Authors: Jennifer L. S. Willoughby, Kelly George, Mark P. Roberto, Hang Gyeong Chin, Patrick Stoiber, Hyunjin Shin, Chandra Sekhar Pedamallu, Scott E. Schaus, Kevin Fitzgerald, Jagesh Shah and Ulla Hansen

    Citation: BMC Cancer 2020 20:552

    Content type: Research article

    Published on:

  24. Prostate cancer (PCa) and type 2 diabetes mellitus (T2DM) are prevalent conditions that often occur concomitantly. However, many aspects of the impact of T2DM, particularly the duration of T2DM and antidiabeti...

    Authors: E. Lin, Hans Garmo, Mieke Van Hemelrijck, Jan Adolfsson, Pär Stattin, Björn Zethelius and Danielle Crawley

    Citation: BMC Cancer 2020 20:551

    Content type: Research article

    Published on:

  25. Regarding the longer-term recurrence rate the optimal activity for the remnant thyroid ablation in patients with differentiated thyroid cancer (DTC) is discussed controversially. For the short-term ablation su...

    Authors: I. Vardarli, F. Weidemann, M. Aboukoura, K. Herrmann, I. Binse and R. Görges

    Citation: BMC Cancer 2020 20:550

    Content type: Research article

    Published on:

  26. Glioma is the most common primary brain tumor, occurring due to the carcinogenesis of glial cells in the brain and spinal cord. Many aspects of the mechanism of its tumorigenesis remain unknown. The relationsh...

    Authors: Zehao Cai, Shoubo Yang, Xiaoyan Li, Feng Chen and Wenbin Li

    Citation: BMC Cancer 2020 20:549

    Content type: Research article

    Published on:

  27. Ramucirumab (RAM) with weekly paclitaxel (wPTX) is a standard second-line therapy for advanced or recurrent gastric cancer. Nanoparticle albumin-bound paclitaxel (nab-PTX), an albumin-bound form of PTX, was de...

    Authors: Kenro Hirata, Yasuo Hamamoto, Masahiko Ando, Chiyo K. Imamura, Kenichi Yoshimura, Kentaro Yamazaki, Shuichi Hironaka and Kei Muro

    Citation: BMC Cancer 2020 20:548

    Content type: Study protocol

    Published on:

  28. To explore the correlation of flash dual source computed tomography perfusion imaging (CTPI) and regional lymph node metastasis of non-small cell lung cancer (NSCLC), and to evaluate the value of CT perfusion ...

    Authors: Tingting Huang, Hui Sun, Xianli Luo, Xuemei Zhang, Kaiyuan Jin, Feng Wang, Lv Sun, Nianlan Cheng, Shuo Wu, Qin Lou and Bangguo Li

    Citation: BMC Cancer 2020 20:547

    Content type: Research article

    Published on:

  29. Multiple Myeloma (MM) is a cancer characterised by the proliferation of malignant plasma cells in the bone marrow. This study examined the treatment preferences of people living with MM compared to the treatme...

    Authors: Simon J. Fifer, Kerrie-Anne Ho, Sean Lybrand, Laurie J. Axford and Steve Roach

    Citation: BMC Cancer 2020 20:546

    Content type: Research article

    Published on:

  30. Unresectable esophageal cancer harbors high mortality despite chemoradiotherapy. Better patient selection for more personalized management may result in better treatment outcomes. We presume the ratio of maxim...

    Authors: Po-Jui Chen, Wing-Keen Yap, Yu-Chuan Chang, Chen-Kan Tseng, Yin-Kai Chao, Jason Chia-Hsun Hsieh, Ping-Ching Pai, Ching-Hsin Lee, Chan-Keng Yang, Albert Tsung-Ying Ho and Tsung-Min Hung

    Citation: BMC Cancer 2020 20:545

    Content type: Research article

    Published on:

  31. We conducted this study to combine the mean standardized uptake value (SUVmean) and neutrophil to lymphocyte ratio (NLR) to establish a strong predictive model for patients with esophageal squamous cell carcin...

    Authors: Chunsheng Wang, Kewei Zhao, Shanliang Hu, Yong Huang, Li Ma, Yipeng Song and Minghuan Li

    Citation: BMC Cancer 2020 20:544

    Content type: Research article

    Published on:

  32. Advances in peri-operative care of surgical oncology patients result in shorter hospital stays. Earlier discharge may bring benefits, but complications can occur while patients are recovering at home. Electron...

    Authors: H. S. Richards, J. M. Blazeby, A. Portal, R. Harding, T. Reed, T. Lander, K. A. Chalmers, R. Carter, R. Singhal, K. Absolom, G. Velikova and K. N. L. Avery

    Citation: BMC Cancer 2020 20:543

    Content type: Research article

    Published on:

  33. Novel biomarkers are required to discern between breast tumors that should be targeted for treatment from those that would never become clinically apparent and/or life threatening for patients. Moreover, thera...

    Authors: Catharina Hagerling, Mark Owyong, Vaishnavi Sitarama, Chih-Yang Wang, Charlene Lin, Renske J. E. van den Bijgaart, Charlotte D. Koopman, Audrey Brenot, Ankitha Nanjaraj, Fredrik Wärnberg, Karin Jirström, Ophir D. Klein, Zena Werb and Vicki Plaks

    Citation: BMC Cancer 2020 20:542

    Content type: Research article

    Published on:

  34. Recent evidence suggests that albumin-to-Alkaline Phosphatase Ratio (AAPR) functions as a novel prognostic marker in several malignancies. However, whether it can predict the prognosis of unresectable pancreat...

    Authors: Ke Zhang, Shu Dong, Yan-Hua Jing, Hui-Feng Gao, Lian-Yu Chen, Yong-Qiang Hua, Hao Chen and Zhen Chen

    Citation: BMC Cancer 2020 20:541

    Content type: Research article

    Published on:

  35. Abdominal/pelvic lymph node (LN) oligometastasis, a pattern of treatment failure, is observed occasionally, and radiotherapy may work as salvage therapy. The optimal prescription dose, however, is yet to be de...

    Authors: Makoto Ito, Takeshi Kodaira, Yutaro Koide, Takahito Okuda, Shinichiro Mizumatsu, Yukihiko Oshima, Arisa Takeuchi, Toshie Mori, Souichirou Abe, Ayumi Asai and Kojiro Suzuki

    Citation: BMC Cancer 2020 20:540

    Content type: Research article

    Published on:

  36. Cervical cancer is caused by Human Papilloma viruses (HPV) and is preceded by precursor stages: Cervical Intraepithelial Neoplasia (CIN). CIN is mostly found in women in their reproductive age and treated with...

    Authors: R. L. O. van de Laar, W. Hofhuis, R. G. Duijnhoven, S. Polinder, W. J. G. Melchers, F. J. van Kemenade, R. L. M. Bekkers and H. J. Van Beekhuizen

    Citation: BMC Cancer 2020 20:539

    Content type: Study protocol

    Published on:

  37. Immunotherapy has become an essential part of cancer treatment after showing great efficacy in various malignancies. However, its effectiveness in pancreatic ductal adenocarcinoma (PDAC), especially in resecta...

    Authors: Saber Amin, Michael Baine, Jane Meza and Chi Lin

    Citation: BMC Cancer 2020 20:538

    Content type: Research article

    Published on:

  39. Adrenal gland metastases are a common diagnostic finding in various tumor diseases. Due to the increased use of imaging methods, they are diagnosed more frequently, especially in asymptomatic patients. SBRT ha...

    Authors: Theresa Voglhuber, Kerstin A. Kessel, Markus Oechsner, Marco M. E. Vogel, Jürgen E. Gschwend and Stephanie E. Combs

    Citation: BMC Cancer 2020 20:536

    Content type: Research article

    Published on:

  40. Expression of forkhead box P3 (FOXP3), a key regulator of T-cell function, in the tumor immune microenvironment is related to survival in classic Hodgkin lymphoma (CHL). Vitamin D receptor (VDR), a transcripti...

    Authors: Gaurav K. Gupta, Tanupriya Agrawal and Monika Pilichowska

    Citation: BMC Cancer 2020 20:535

    Content type: Research article

    Published on:

  41. The aim of this study was to establish a comprehensive nomogram for the cancer-specific survival (CSS) of patients with upper-tract urothelial carcinoma (UTUC) and compare it with the traditional American Join...

    Authors: Chengzhuo Li, Jin Yang, Fengshuo Xu, Didi Han, Shuai Zheng, Rahel Elishilia Kaaya, Shengpeng Wang and Jun Lyu

    Citation: BMC Cancer 2020 20:534

    Content type: Research article

    Published on:

  42. Accurate diagnosis of early lung cancer from small pulmonary nodules (SPN) is challenging in clinical setting. We aimed to develop a radiomic nomogram to differentiate lung adenocarcinoma from benign SPN.

    Authors: Qin Liu, Yan Huang, Huai Chen, Yanwen Liu, Ruihong Liang and Qingsi Zeng

    Citation: BMC Cancer 2020 20:533

    Content type: Research article

    Published on:

  43. Whole brain radiation therapy (WBRT) is the standard therapy for multiple brain metastases. However, WBRT has a poor local tumor control and is associated with a decline in neurocognitive function (NCF). Aim o...

    Authors: Anca-Ligia Grosu, Lars Frings, Iryna Bentsalo, Oliver Oehlke, Franziska Brenner, Angelika Bilger, Jamina Tara Fennell, Thomas Rothe, Sabine Schneider-Fuchs, Erika Graf, Claudia Schmoor, Jürgen Beck, Gerhild Becker, Michael Bock, Karl Egger, Horst Urbach…

    Citation: BMC Cancer 2020 20:532

    Content type: Study protocol

    Published on:

  44. Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge re...

    Authors: Tomer Boldes, Keren Merenbakh-Lamin, Shani Journo, Eliya Shachar, Doron Lipson, Adva Yeheskel, Metsada Pasmanik-Chor, Tami Rubinek and Ido Wolf

    Citation: BMC Cancer 2020 20:531

    Content type: Research article

    Published on:

  45. Formulae of estimated glomerular filtration rate (eGFR) based on serum creatinine (Scr) are routinely used in oncology patients, however, they are inaccurate in some populations. Our aim was to assess the agre...

    Authors: Yichun Cheng, Liu Huang, Yunfeng Han, Chummun Vanisha, Shuwang Ge and Gang Xu

    Citation: BMC Cancer 2020 20:530

    Content type: Research article

    Published on:

  46. Sarcomas constitute a heterogeneous group of tumors with different clinical behaviors and variable responses to systemic therapies. Recent immunotherapy studies with PD1 inhibitors (PD1i) show promising result...

    Authors: Dionisia Quiroga, David A. Liebner, Jennifer S. Philippon, Sarah Hoffman, Yubo Tan, James L. Chen, Scott Lenobel, Paul E. Wakely Jr, Raphael Pollock and Gabriel Tinoco

    Citation: BMC Cancer 2020 20:527

    Content type: Research article

    Published on:

  47. Previous researches have reported that tripartite motif-containing 44 (TRIM44) is related to the prognosis of multiple human tumors. This study was designed to systematically assess the prognostic value of TRI...

    Authors: Guoliang Xiao, Qiuxi Yang, Ziwei Bao, Haixia Mao, Yi Zhang and Shibu Lin

    Citation: BMC Cancer 2020 20:525

    Content type: Research article

    Published on:

  48. microRNAs (miRNAs) play essential roles in the development and progression of gastric cancer (GC). Although aberrant miR-874 expression has been reported in various human cancers, its role in GC remains obscure.

    Authors: Qin Hui Sun, Zong Xiu Yin, Zhi Li, Shu Bo Tian, Hong Chang Wang, Fang Xu Zhang, Le Ping Li, Chun Ning Zheng and Shuai Kong

    Citation: BMC Cancer 2020 20:522

    Content type: Research article

    Published on:

  49. According to the proportion of glandular and squamous pathological components, adenosquamous carcinoma (ASC) could be divided into adenocarcinoma (AC) and squamous cell carcinoma (SCC) predominant subtypes. Du...

    Authors: Yangli Liu, Ying Zhu, Lihong Bai, Fengjia Chen, Jue Wang and Yubiao Guo

    Citation: BMC Cancer 2020 20:520

    Content type: Research article

    Published on:

  50. Treatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a transmembrane protein that is known for its use in diagnostics and targete...

    Authors: Thomas J. W. Klein Nulent, Matthijs H. Valstar, Laura A. Smit, Ludwig E. Smeele, Nicolaas P. A. Zuithoff, Bart de Keizer, Remco de Bree, Robert J. J. van Es and Stefan M. Willems

    Citation: BMC Cancer 2020 20:519

    Content type: Research article

    Published on:

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