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  1. As the number of PET/CT scanners increases and FDG PET/CT becomes a common imaging modality for oncology, the demands for automated detection systems on artificial intelligence (AI) to prevent human oversight ...

    Authors: Keisuke Kawauchi, Sho Furuya, Kenji Hirata, Chietsugu Katoh, Osamu Manabe, Kentaro Kobayashi, Shiro Watanabe and Tohru Shiga

    Citation: BMC Cancer 2020 20:227

    Content type: Research article

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  2. Even though treatment modalities such as adjuvant systemic radio-chemotherapy and neoadjuvant chemotherapy (NAC) have individually have improved overall survival (OS) and progression-free survival (PFS) rates ...

    Authors: Maneesh Kumarsing Beeharry, Zhen-Tian Ni, Zhong Yin Yang, Ya Nan Zheng, Run Hua Feng, Wen-Tao Liu, Chao Yan, Xue Xin Yao, Chen Li, Min Yan and Zheng-Gang Zhu

    Citation: BMC Cancer 2020 20:224

    Content type: Study protocol

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  3. The burden of disease due to cancer remains substantial. Since the value of real-world evidence has also been recognised by regulatory agencies, we established a Research Ethics Committee (REC) approved resear...

    Authors: C. Moss, A. Haire, F. Cahill, D. Enting, S. Hughes, D. Smith, E. Sawyer, A. Davies, J. Zylstra, K. Haire, A. Rigg and M. Van Hemelrijck

    Citation: BMC Cancer 2020 20:187

    Content type: Database

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  4. Cognitive therapy has been shown to reduce fear of cancer recurrence (FCR), mainly in breast cancer survivors. The accessibility of cognitive behavioural interventions could be further improved by Internet del...

    Authors: Johanne Dam Lyhne, Allan ‘ Ben’ Smith, Lisbeth Frostholm, Per Fink and Lars Henrik Jensen

    Citation: BMC Cancer 2020 20:223

    Content type: Study protocol

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  5. Following publication of the original article [1], the authors reported that they had misspelt the name of a cell line and supplied the incorrect Fig. 7 for publication.

    Authors: Minhua Rong, Gang Chen and Yiwu Dang

    Citation: BMC Cancer 2020 20:221

    Content type: Correction

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    The original article was published in BMC Cancer 2013 13:21

  6. To retrospectively investigate the clinical characteristics, initial treatment, relapse, therapy outcome, and prognosis of Chinese patients with primary testicular lymphoma (PTL) through analysis of the cases ...

    Authors: Bo Chen, De-Hong Cao, Li Lai, Jian-Bing Guo, Ze-Yu Chen, Yin Huang, Shi Qiu, Tian-Hai Lin, Yue Gou, Na Ma, Lu Yang, Liang-Ren Liu and Qiang Wei

    Citation: BMC Cancer 2020 20:220

    Content type: Research article

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  7. We performed a pooled analysis of the COMPARZ study assessing efficacy and safety of pazopanib versus sunitinib in treatment-naïve Chinese patients with locally advanced and/or metastatic renal cell carcinoma ...

    Authors: Xinan Sheng, Jie Jin, Zhisong He, Yiran Huang, Aiping Zhou, Jinwan Wang, Xiubao Ren, Dingwei Ye, Xu Zhang, Shukui Qin, Fangjian Zhou, Binhui Wang and Jun Guo

    Citation: BMC Cancer 2020 20:219

    Content type: Research article

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  8. Oral squamous cell carcinoma (OSCC) is an aggressive human malignancy. Because of late diagnosis and recurrence of OSCC, the treatment of patients with OSCC is often ineffective. Thus, finding novel biomarkers...

    Authors: Ratakorn Srisuttee, Areeya Arayataweegool, Patnarin Mahattanasakul, Napadon Tangjaturonrasme, Virachai Kerekhanjanarong, Somboon Keelawat, Apiwat Mutirangura and Nakarin Kitkumthorn

    Citation: BMC Cancer 2020 20:218

    Content type: Research article

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  9. Colorectal cancer (CRC) is the most common cancer and a leading cause of death worldwide. Extracellular matrix (ECM) proteins regulate tumor growth and development in CRC. Elastin (ELN) is a component of ECM p...

    Authors: Jinzhi Li, Xiaoyue Xu, Yanyan Jiang, Nicole G. Hansbro, Philip M. Hansbro, Jincheng Xu and Gang Liu

    Citation: BMC Cancer 2020 20:217

    Content type: Research article

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  10. Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging ca...

    Authors: Yosep Chong, Nishant Thakur, Kwang Yeol Paik, Eun Jung Lee and Chang Suk Kang

    Citation: BMC Cancer 2020 20:216

    Content type: Research article

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  11. Poly (ADP-ribose) polymerase (PARP) inhibitors are approved for the treatment of breast cancer susceptibility genes 1 and 2 (BRCA1/2) mutant ovarian and breast cancers, and are now being evaluated in metastatic c...

    Authors: Andrew D. Simmons, Minh Nguyen and Elias Pintus

    Citation: BMC Cancer 2020 20:215

    Content type: Case report

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  12. Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer. Ubiquitin-specific protease (USP)44 has been reported to be involved in various cancers. We investigated the function, ro...

    Authors: Jiangqiao Zhou, Tianyu Wang, Tao Qiu, Zhongbao Chen, Xiaoxiong Ma, Long Zhang and Jilin Zou

    Citation: BMC Cancer 2020 20:214

    Content type: Research article

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  13. Tumor mutational burden (TMB) is a potential biomarker for immune checkpoint therapy and prognosis. The impact of TMB on clinical outcomes and the correlation coefficient between exome sequencing and targeted ...

    Authors: Lihong Wang, Jia Ge, Yang Lan, Yu Shi, Ying Luo, Yuhuan Tan, Mei Liang, Song Deng, Xia Zhang, Wenying Wang, Yaoyao Tan, Yuanyuan Xu and Tao Luo

    Citation: BMC Cancer 2020 20:213

    Content type: Research article

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  14. The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, sugge...

    Authors: Nicole E. Mealey, Dylan E. O’Sullivan, Joy Pader, Yibing Ruan, Edwin Wang, May Lynn Quan and Darren R. Brenner

    Citation: BMC Cancer 2020 20:212

    Content type: Research article

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  15. Acute lymphoblastic leukemia (ALL), the most common childhood malignancy, is characterized by recurring structural chromosomal alterations and genetic alterations, whose detection is critical in diagnosis, ris...

    Authors: Honghong Zhang, Hongsheng Wang, Xiaowen Qian, Shuai Gao, Jieqi Xia, Junwen Liu, Yanqin Cheng, Jie Man and Xiaowen Zhai

    Citation: BMC Cancer 2020 20:211

    Content type: Research article

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  16. Following publication of the original article [1], the authors reported an error in Fig. 1f.

    Authors: Chaoyang Sun, Ensong Guo, Bo Zhou, Wanying Shan, Jia Huang, Danhui Weng, Peng Wu, Changyu Wang, Shixuan Wang, Wei Zhang, Qinglei Gao, Xiaoyan Xu, Beibei Wang, Junbo Hu, Ding Ma and Gang Chen

    Citation: BMC Cancer 2020 20:210

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2019 19:1061

  17. Tumor budding (TB) is used as an indicator of poor prognosis in various cancers. However, studies on TB in perihilar cholangiocarcinoma are still limited. We examined the significance of TB in resected perihil...

    Authors: Takahiro Ito, Naohisa Kuriyama, Yuji Kozuka, Haruna Komatsubara, Ken Ichikawa, Daisuke Noguchi, Aoi Hayasaki, Tekehiro Fujii, Yusuke Iizawa, Hiroyuki Kato, Akihiro Tanemura, Yasuhiro Murata, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai…

    Citation: BMC Cancer 2020 20:209

    Content type: Research article

    Published on:

  18. Inflammation-related parameters have been revealed to have prognostic value in multiple caners. However, the significance of some inflammation-related parameters, including the peripheral blood neutrophil-to-l...

    Authors: Li-jian Xia, Wen Li, Jian-cheng Zhai, Chuan-wang Yan, Jing-bo Chen and Hui Yang

    Citation: BMC Cancer 2020 20:208

    Content type: Research article

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  19. Dissociated responses (DR) are phenomena in which some tumors shrink, whereas others progress during treatment of patients with cancer. The purpose of the present study was to evaluate the frequency and progno...

    Authors: Takehiro Tozuka, Satoru Kitazono, Hiroaki Sakamoto, Hiroshi Yoshida, Yoshiaki Amino, Shinya Uematsu, Takahiro Yoshizawa, Tsukasa Hasegawa, Ken Uchibori, Noriko Yanagitani, Atsushi Horiike, Takeshi Horai, Masahiro Seike, Akihiko Gemma and Makoto Nishio

    Citation: BMC Cancer 2020 20:207

    Content type: Research article

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  20. Classical MPNs including ET and PMF have a chronic course and potential for leukaemic transformation. Timely diagnosis is obligatory to ensure appropriate management and positive outcomes. The aim of this stud...

    Authors: Uzma Zaidi, Gul Sufaida, Munazza Rashid, Bushra Kaleem, Sidra Maqsood, Samina Naz Mukry, Rifat Zubair Ahmed Khan, Saima Munzir, Munira Borhany and Tahir Sultan Shamsi

    Citation: BMC Cancer 2020 20:205

    Content type: Research article

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  21. Poly (ADP-ribose) polymerase inhibitors targeting BRCA1/2 mutations are available for treating patients with high-grade serous ovarian cancer. These treatments may be more appropriately directed to patients who m...

    Authors: Kyung Jin Eoh, Hye Min Kim, Jung-Yun Lee, Sunghoon Kim, Sang Wun Kim, Young Tae Kim and Eun Ji Nam

    Citation: BMC Cancer 2020 20:204

    Content type: Research article

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  22. The current study aimed to evaluate the outcomes of patients with unresectable non-metastatic locally advanced pancreatic adenocarcinoma (LAPA) who did not benefit from resection considering the treatment stra...

    Authors: Jonathan Garnier, Jacques Ewald, Ugo Marchese, Marine Gilabert, Simon Launay, Laurence Moureau-Zabotto, Flora Poizat, Marc Giovannini, Jean-Robert Delpero and Olivier Turrini

    Citation: BMC Cancer 2020 20:203

    Content type: Research article

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  23. Na+/H+ exchanger regulatory factor 1 (NHERF1) is an important scaffold protein participates in the modulation of a variety of intracellular signal pathways. NHERF1 was able to enhance the effects of chemo-drugs i...

    Authors: Fenglian Yang, Mu Hu, Siyuan Chang, Jing Huang, Yang Si, Jinghui Wang, Shan Cheng and Wen G. Jiang

    Citation: BMC Cancer 2020 20:202

    Content type: Research article

    Published on:

  24. Existing data from several reports on the association between lipid profile and ovarian tumour (OT) suggests divergent conclusions. Our aim was to examine whether circulating lipid profile: total cholesterol (...

    Authors: Justina Ucheojor Onwuka, Akinkunmi Paul Okekunle, Olaniyi Matthew Olutola, Onoja Matthew Akpa and Rennan Feng

    Citation: BMC Cancer 2020 20:200

    Content type: Research article

    Published on:

  25. The fine-needle aspiration (FNA) biopsy was broadly applied to clinical diagnostics evaluation for thyroid carcinomas nodule, while companioning with higher uncertainty rate (15~30%) to identify malignancy for...

    Authors: Dandan Wu, Shudong Hu, Yongzhong Hou, Yingying He and Shubai Liu

    Citation: BMC Cancer 2020 20:199

    Content type: Research article

    Published on:

  26. Median survival for patients with glioblastoma is less than a year. Standard treatment consists of surgical debulking if feasible followed by temozolomide chemo-radiotherapy. The immune checkpoint inhibitor ip...

    Authors: Nicholas F. Brown, Stasya M. Ng, Claire Brooks, Tim Coutts, Jane Holmes, Corran Roberts, Leena Elhussein, Peter Hoskin, Tim Maughan, Sarah Blagden and Paul Mulholland

    Citation: BMC Cancer 2020 20:198

    Content type: Study protocol

    Published on:

  27. BRCA1/2 germline mutation related cancers are candidates for new immune therapeutic interventions. This study was a hypothesis generating exploration of genomic data collected at diagnosis for 19 patients. The...

    Authors: Ewa Przybytkowski, Thomas Davis, Abdelrahman Hosny, Julia Eismann, Ursula A. Matulonis, Gerburg M. Wulf and Sheida Nabavi

    Citation: BMC Cancer 2020 20:197

    Content type: Research article

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  28. The expression of vascular endothelial growth factor (VEGF)-A/ VAGF receptors (VEGFRs) signaling plays a pivotal role in the tumor angiogenesis and the development of the immunosuppressive tumor microenvironme...

    Authors: Ryota Tamura, Yukina Morimoto, Kenzo Kosugi, Mizuto Sato, Yumiko Oishi, Ryo Ueda, Ryogo Kikuchi, Hideaki Nagashima, Shinobu Noji, Yutaka Kawakami, Hikaru Sasaki, Kazunari Yoshida and Masahiro Toda

    Citation: BMC Cancer 2020 20:196

    Content type: Research article

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  29. Donor acute lymphoblastic leukemia with recipient intact is a rare condition. We report a case of donor developing acute lymphoblastic leukemia 8 yrs after donating both bone marrow and peripheral blood hemato...

    Authors: Di Zhou, Ting Xie, Suning Chen, Yipeng Ling, Yueyi Xu, Bing Chen, Jian Ouyang and Yonggong Yang

    Citation: BMC Cancer 2020 20:195

    Content type: Case report

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  30. After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surve...

    Authors: Xiaobin Zhang, Ben M. Eyck, Yang Yang, Jun Liu, Yin-Kai Chao, Ming-Mo Hou, Tsung-Min Hung, Qingsong Pang, Zhen-Tao Yu, Hongjing Jiang, Simon Law, Ian Wong, Ka-On Lam, Berend J. van der Wilk, Ate van der Gaast, Manon C. W. Spaander…

    Citation: BMC Cancer 2020 20:194

    Content type: Study protocol

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  31. To determine the optimal timing of the first Magnetic Resonance Imaging (MRI) scan after curative-intent radiotherapy (RT) for nasopharyngeal carcinoma (NPC), and evaluate the role of MRI in surveillance for l...

    Authors: Katherine Meng, Jeremy Tey, Francis Cho Hao Ho, Hira Asim and Timothy Cheo

    Citation: BMC Cancer 2020 20:193

    Content type: Research article

    Published on:

  32. Altered glycosylation associated with hepatocellular carcinoma (HCC) is well documented. However, few reports have investigated the association between dedifferentiation and glycosylation. Therefore, the aim o...

    Authors: Hiroomi Takayama, Masayuki Ohta, Yukio Iwashita, Hiroki Uchida, Yuki Shitomi, Kazuhiro Yada and Masafumi Inomata

    Citation: BMC Cancer 2020 20:192

    Content type: Research article

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  33. This case represents the first report of malignant primary cardiac tumour in a patient with Lynch Syndrome associated with MSH2 pathogenic variant.

    Authors: Pasquale Paolisso, Giulia Saturi, Alberto Foà, Maristella Saponara, Margherita Nannini, Maria Abbondanza Pantaleo, Ornella Leone, Daniela Turchetti, Daniele Calistri, Carlo Savini, Davide Pacini, Carmine Pizzi and Nazzareno Galiè

    Citation: BMC Cancer 2020 20:191

    Content type: Case report

    Published on:

  34. The exhaustive collection of new sarcoma cases and their second histologic review offer a unique opportunity to study their incidence and time trends in France according to the major subtypes.

    Authors: Brice Amadeo, Nicolas Penel, Jean-Michel Coindre, Isabelle Ray-Coquard, Karine Ligier, Patricia Delafosse, Anne-Marie Bouvier, Sandrine Plouvier, Justine Gallet, Aude Lacourt, Gaëlle Coureau, Alain Monnereau, Simone Mathoulin-Pélissier and Emmanuel Desandes

    Citation: BMC Cancer 2020 20:190

    Content type: Research article

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  35. This study aimed to compare the survival outcomes of radio-chemotherapy (R-CT) and radical hysterectomy with postoperative standard therapy (RH) in stage IB1-IIA2 cervical cancer patients.

    Authors: Ping Liu, Lihong Lin, Yanxiang Kong, Zhifeng Huo, Lin Zhu, Xiaonong Bin, Jinghe Lang and Chunlin Chen

    Citation: BMC Cancer 2020 20:189

    Content type: Research article

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  36. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) staging classifications are two broadly used systems for pancreatic neuroendocrine tumors. This study aims to...

    Authors: Haihong Wang, Zhenyu Lin, Guiling Li, Dejun Zhang, Dandan Yu, Qili Lin, Jing Wang, Ye Zhao, Guoliang Pi and Tao Zhang

    Citation: BMC Cancer 2020 20:188

    Content type: Research article

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  37. CYP2A6 is an enzyme involved in oxidation of a number of environmental chemicals, including nicotine, pro-carcinogenic nitrosamines and polycyclic aromatic hydrocarbons (PAHs). The whole gene deletion of CYP2A...

    Authors: Maidina Abudushataer, Noriko Sato, Makiko Mieno, Motoji Sawabe, Masaaki Muramatsu and Tomio Arai

    Citation: BMC Cancer 2020 20:186

    Content type: Research article

    Published on:

  38. To analyze the effects of BRCA1/2 mutations on chemotherapy response scores (CRS) and survival in a cohort of patients with advanced-stage ovarian cancer who were treated with neoadjuvant chemotherapy (NAC) follo...

    Authors: Yong Jae Lee, Hyun-Soo Kim, John Hoon Rim, Jung-Yun Lee, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim and Young Tae Kim

    Citation: BMC Cancer 2020 20:185

    Content type: Research article

    Published on:

  39. Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be target...

    Authors: Anna Richter, Sina Sender, Annemarie Lenz, Rico Schwarz, Burkhard Hinz, Gudrun Knuebel, Anett Sekora, Hugo Murua Escobar, Christian Junghanss and Catrin Roolf

    Citation: BMC Cancer 2020 20:184

    Content type: Research article

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  40. Serum miRNA was once found as potential disease survival index,thus we investigated the role of miRNA in predicting prognosis in loco-regionally advanced NPC patients treated with CCRT.

    Authors: Zhimin Zhang, Jiangbiao Huang, Ge Wang, Feng Jin, Jijun Zheng, He Xiao, Lin Lei, Jia Luo and Chuan Chen

    Citation: BMC Cancer 2020 20:183

    Content type: Research article

    Published on:

  41. It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in ...

    Authors: Zhengwu Sun, Xiaoyan Lan, Shizhao Xu, Shen Li and Yalin Xi

    Citation: BMC Cancer 2020 20:180

    Content type: Research article

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  42. Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune syst...

    Authors: Anastasios Dimou, Gregory Barron, Daniel T. Merrick, Jason Kolfenbach and Robert C. Doebele

    Citation: BMC Cancer 2020 20:177

    Content type: Case report

    Published on:

  43. The development of tumor cells inside the lymphatics or blood vessels is known as lymphovascular invasion (LVI). The correlation between LVI, lymph node metastasis (LNM), and the diagnosis of superficial esoph...

    Authors: Jinxin Yang, Zhouyi Lu, Lintao Li, Yong Li, Yulong Tan, Dekang Zhang and An Wang

    Citation: BMC Cancer 2020 20:176

    Content type: Research article

    Published on:

  44. Programmed cell death 1 (PD-1) is one of the immune checkpoint molecules that negatively regulate the function of T cells. Although recent studies indicate that PD-1 is also expressed on other immune cells bes...

    Authors: Yusuke Kono, Hiroaki Saito, Wataru Miyauchi, Shota Shimizu, Yuki Murakami, Yuji Shishido, Kozo Miyatani, Tomoyuki Matsunaga, Yoji Fukumoto, Yuji Nakayama, Chiye Sakurai, Kiyotaka Hatsuzawa and Yoshiyuki Fujiwara

    Citation: BMC Cancer 2020 20:175

    Content type: Research article

    Published on:

  45. The European Guidelines for breast cancer screening suggest that the impact of population-based mammography screening programmes (MSP) may be assessed using the relative reduction in the incidence of advanced ...

    Authors: Laura Khil, Jan Heidrich, Ina Wellmann, Vanessa Kääb-Sanyal, Stefanie Weigel, Walter Heindel, Hans-Werner Hense and Oliver Heidinger

    Citation: BMC Cancer 2020 20:174

    Content type: Research article

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  46. Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death in women worldwide. Recently, studies have been published with inconsistent findings regarding whether sarcopenia is a ...

    Authors: Xiao-Ming Zhang, Qing-Li Dou, Yingchun Zeng, Yunzhi Yang, Andy S. K. Cheng and Wen-Wu Zhang

    Citation: BMC Cancer 2020 20:172

    Content type: Research article

    Published on:

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