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  1. Precision oncology, defined as treatment of patients with targeted therapies matched to specific molecular alterations, has entered routine clinical practice. Particularly in patients with advanced cancer or h...

    Authors: Uwe M. Martens, Jan Schröder, Fee Bengsch, Ludger Sellmann, Sabine Busies, Stefanie Frank-Gleich, Matthias Zaiss, Thomas Decker, Andreas Schneeweiss, Martin Schuler, Sina Grebhardt, Stefan Zacharias, Norbert Marschner, Benjamin Kasenda, Karin Potthoff and Corinne Vannier
    Citation: BMC Cancer 2023 23:543
    Content type: Study protocol Published on:

  3. Radiotherapy (RT) is the standard of care for most advanced head and neck squamous cell carcinoma (HNSCC) and results in an unfavorable 5-year overall survival of 40%. Despite strong biological rationale, comb...

    Authors: Joris B. W. Elbers, Pascal A. Gunsch, Reno Debets, Stijn Keereweer, Esther van Meerten, Jaap Zindler, Yvette van Norden, Mischa S. Hoogeman, Gerda M. Verduijn, Michiel Kroesen and Remi A. Nout
    Citation: BMC Cancer 2023 23:541
    Content type: Study Protocol Published on:

  4. The current management of lung cancer patients has reached a high level of complexity. Indeed, besides the traditional clinical variables (e.g., age, sex, TNM stage), new omics data have recently been introduc...

    Authors: Filippo Lococo, Luca Boldrini, Charles-Davies Diepriye, Jessica Evangelista, Camilla Nero, Sara Flamini, Angelo Minucci, Elisa De Paolis, Emanuele Vita, Alfredo Cesario, Salvatore Annunziata, Maria Lucia Calcagni, Marco Chiappetta, Alessandra Cancellieri, Anna Rita Larici, Giuseppe Cicchetti…
    Citation: BMC Cancer 2023 23:540
    Content type: Study Protocol Published on:

  5. Patients with locally advanced irresectable or clinically node positive urothelial cancer (UC) have a poor outcome. Currently, these patients can only be cured by receiving induction chemotherapy and, if an ad...

    Authors: V. C. Rutten, Y. Salhi, G. J. Robbrecht, R. de Wit, G. J.L.H. van Leenders, T. C.M. Zuiverloon and J. L. Boormans
    Citation: BMC Cancer 2023 23:539
    Content type: Study Protocol Published on:

  6. The CARD trial was conducted in patients with metastatic castration-resistant prostate cancer (mCRPC) who had received docetaxel and experienced disease progression within 1 year on an androgen receptor-axis-t...

    Authors: Hideyasu Matsuyama, Nobuaki Matsubara, Hirotaka Kazama, Takeshi Seto, Yoshinori Sunaga and Kazuhiro Suzuki
    Citation: BMC Cancer 2023 23:538
    Content type: Research Published on:

  8. Lymph node size is considered as a criterion for possible lymph node metastasis in imageology. Micro lymph nodes are easily overlooked by surgeons and pathologists. This study investigated the influencing fact...

    Authors: Yuan Tian, Yue Pang, Pei-Gang Yang, Hong-Hai Guo, Yang Liu, Ze Zhang, Ping-An Ding, Tao Zheng, Yong Li, Li-Qiao Fan, Zhi-Dong Zhang, Dong Wang, Xue-Feng Zhao, Bi-Bo Tan, Yu Liu and Qun Zhao
    Citation: BMC Cancer 2023 23:536
    Content type: Research Published on:

  9. Our study was to investigate the correlation correlation between FDG uptake and PD-L1 expression of liver metastasis in patients with colon cancer, and to determine the value of FDG-PET in predicting PD-L1 exp...

    Authors: Yan Qiao, Xiaomeng Li, Yongquan Hu, Pu Guo, Hengchao Liu and Hong Sun
    Citation: BMC Cancer 2023 23:535
    Content type: Research Published on:

  10. Vulvar squamous cell carcinoma (VSCC) is a relatively rare gynecologic cancer. Unlike cervical squamous cell carcinoma (CSCC), in which nearly all cases are caused by HPV infection, most VSCCs are HPV-independ...

    Authors: Tao Zhang, Yingfan Zhu, Jie Luo, Juanqing Li, Shuang Niu, Hao Chen and Feng Zhou
    Citation: BMC Cancer 2023 23:534
    Content type: Research Published on:

  11. This study aims to (1) identify preoperative testing-based characteristics associated with enhanced prognosis and survival for cholangiocarcinoma patients, and (2)create a distinctive nomogram to anticipate ea...

    Authors: Shurui Zhou, Yue Zhao, Yanzong Lu, Weiling Liang, Jianmin Ruan, Lijun Lin, Haoming Lin and Kaihong Huang
    Citation: BMC Cancer 2023 23:533
    Content type: Research Published on:

  12. Cancer patients with newly created ostomies face complications that reduce quality of life (QOL) and increase morbidity and mortality. This proof-of-concept study examined the feasibility, usability, acceptabi...

    Authors: Shenmeng Xu, Xianming Tan, Chunxuan Ma, Rebecca S. McElyea, Karl Shieh, Angela M. Stover, Angela Smith, Karyn Stitzenberg, Ethan Basch and Lixin Song
    Citation: BMC Cancer 2023 23:532
    Content type: Research Published on:

  13. Venous thromboembolism (VTE) and cancer are strongly associated. In France, evidence on patients with pancreatic, upper GI [gastrointestinal], lower GI, lung, or breast cancer-associated VTE and their hospital...

    Authors: F. Couturaud, I. Mahé, J. Schmidt, J-C. Gleize, T. Lafon, A. Saighi, F. Sedjelmaci, L. Bertoletti and P. Mismetti
    Citation: BMC Cancer 2023 23:531
    Content type: Research Published on:

  14. Tumor necrosis (TN) was associated with poor prognosis. However, the traditional classification of TN ignored spatial intratumor heterogeneity, which may be associated with important prognosis. The purpose of ...

    Authors: Jianhua Chen, Zhijun Li, Zhonghua Han, Deyong Kang, Jianli Ma, Yu Yi, Fangmeng Fu, Wenhui Guo, Liqin Zheng, Gangqin Xi, Jiajia He, Lida Qiu, Lianhuang Li, Qingyuan Zhang, Chuan Wang and Jianxin Chen
    Citation: BMC Cancer 2023 23:530
    Content type: Research Published on:

  15. Pancreatic neuroendocrine tumors (PNETs) are one of the most common endocrine tumors, and liver metastasis (LMs) are the most common location of metastasis from PNETS; However, there is no valid nomogram to pr...

    Authors: Jianbo Li, Long Huang, Chengyu Liao, Guozhong Liu, Yifeng Tian and Shi Chen
    Citation: BMC Cancer 2023 23:529
    Content type: Research Published on:

  16. New immunotherapeutic strategies based on predictors are urgently needed. Toll-like receptor adaptor interacting with SLC15A4 on the lysosome (TASL) was recently confirmed to fulfill an important role in the i...

    Authors: Huanyu Li, Xiaoyu Sun, Yanyun Zhao, Changzhu Zhang, Kai Jiang, Jie Ren, Lijuan Xing and Miao He
    Citation: BMC Cancer 2023 23:528
    Content type: Research Published on:

  17. Whether isocitrate dehydrogenase 2 (IDH2) R140 and R172 gene mutations affect the prognosis of patients with acute myeloid leukemia (AML) is controversial. Here, we performed a meta-analysis to assess their pr...

    Authors: Yao Qin, Kai Shen, Ting Liu and Hongbing Ma
    Citation: BMC Cancer 2023 23:527
    Content type: Research Published on:

  18. NEDD4 family represent an important group of E3 ligases, which regulate various cellular pathways of cell proliferation, cell junction and inflammation. Emerging evidence suggested that NEDD4 family members pa...

    Authors: Liangzi Cao, Hao Li, Xiaofang Liu, Yubang Wang, Bowen Zheng, Chengzhong Xing, Naijin Zhang and Jingwei Liu
    Citation: BMC Cancer 2023 23:526
    Content type: Research Published on:

  19. Cancer stemness has been proven to affect tumorigenesis, metastasis, and drug resistance in various cancers, including lung squamous cell carcinoma (LUSC). We intended to develop a clinically applicable stemne...

    Authors: Jinzhi Lai, Xinyi Lin, Huangna Zheng, Bilan Xie and Deqiang Fu
    Citation: BMC Cancer 2023 23:525
    Content type: Research Published on:

  20. Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers based on five-year survival rates. Genes contributing to chemoresistance represent novel therapeutic targets that can improve treatment r...

    Authors: Emily R. Gordon, Carter A. Wright, Mikayla James and Sara J. Cooper
    Citation: BMC Cancer 2023 23:524
    Content type: Research Published on:

  21. We conducted a systematic review and meta-analysis to summarize the predictive and prognostic ability of the log odds of positive lymph nodes (LODDS) staging system and compare it with pathological N (pN) clas...

    Authors: Yiding Li, Guiling Wu, Jinqiang Liu, Yujie Zhang, Wanli Yang, Xiaoqian Wang, Lili Duan, Liaoran Niu, Junfeng Chen, Wei Zhou, Weili Han, Jing Wang, Helun Zhong, Gang Ji, Daiming Fan and Liu Hong
    Citation: BMC Cancer 2023 23:523
    Content type: Research Published on:

  22. Hepatocellular carcinoma (HCC) is considered one of the most common cancers, characterized by low early detection and high mortality rates, and is a global health challenge. Immunogenic cell death (ICD) is def...

    Authors: Cai-Feng Lin, Zhi-Wen Chen, Feng-Ping Kang, Jian-Fei Hu, Long Huang, Cheng-Yu Liao, Jian-Lin Lai, Yi Huang, Zu-Wei Wang, Yi-Feng Tian and Shi Chen
    Citation: BMC Cancer 2023 23:522
    Content type: Research Published on:

  23. We aim to clarify the controversial associations between EBV-related antibodies and gastric cancer risk.

    Authors: Yun Du, Xia Yu, Ellen T. Chang, Li Yin, Shifeng Lian, Biaohua Wu, Fugui Li, Zhiheng Liang, Yumei Zeng, Bing Chu, Kuangrong Wei, Jiyun Zhan, Xuejun Liang, Weimin Ye and Mingfang Ji
    Citation: BMC Cancer 2023 23:521
    Content type: Research Published on:

  25. Melanoma differentiation-associated gene 7 (Mda-7) encodes IL-24, which can induce apoptosis in cancer cells. A novel gene therapy approach to treat deadly brain tumors, recombinant mda-7 adenovirus (Ad/mda-7)...

    Authors: Seyedeh Maliheh Babazadeh, Mohammad Reza Zolfaghari, Mohsen Zargar, Kazem Baesi, Sayed Younes Hosseini and Amir Ghaemi
    Citation: BMC Cancer 2023 23:519
    Content type: Research Published on:

  26. Size and number of lymph nodes (LNs) were reported to be associated with the prognosis of stage II colorectal cancer (CRC). The purpose of this study was to determine the prognostic role of the size of LNs (SL...

    Authors: Shanyou Tong, Menglei Li, Yichao Bao, Long Zhang, Ping Lu, Tong Tong and Junjie Peng
    Citation: BMC Cancer 2023 23:518
    Content type: Research Published on:

  27. We aimed to evaluate the safety and efficacy of intraluminal iodine-125 seed strand brachytherapy and percutaneous nephrostomy in patients with ureteral carcinoma.

    Authors: Yonghua Bi, Dechao Jiao, Jianhao Zhang, Yang Wang, Mengdan Su, Jianzhuang Ren and Xinwei Han
    Citation: BMC Cancer 2023 23:517
    Content type: Research Published on:

  28. The aquaporin (AQP) family of proteins has been implicated in the proliferation and growth of gliomas. Expression of AQP8 is higher in human glioma tissues than in normal brain tissues and is positively correl...

    Authors: Zhang Hao, Sheng Huajun, Guo Zhen, Xing Yu, Liu Qian, Cai Ziling, Shen Zihao, Xia Qingqian and Zhu Shujuan
    Citation: BMC Cancer 2023 23:516
    Content type: Research Published on:

  29. Our purpose was to ensure that the dose constraints of the organs at risk (OARs) were not exceeded while increasing the prescription dose to the planning target volume (PTV) from 45 to 50.4 Gray (Gy) with the ...

    Authors: Alparslan Serarslan, Yalçın Daştan, Telat Aksu, Rana Elif Yıldız, Bilge Gürsel, Deniz Meydan and Nilgün Özbek Okumuş
    Citation: BMC Cancer 2023 23:515
    Content type: Research Published on:

  30. The association involving mismatch repair (MMR) genes, molecular subtype and specific immune cell group in tumor microenvironment has been focused by more recent studies. Its prognosis value in lung adenocarci...

    Authors: Liangliang Cai, Hujia Hua, Xingyu Jiang, Xintian Xu, Hua Bai, Li Qian and Jianchun Duan
    Citation: BMC Cancer 2023 23:514
    Content type: Research Published on:

  31. Cancer cachexia, occurring in ~ 80% pancreatic cancer (PC) patients overall, is a paraneoplastic syndrome mediated by cancer-induced systemic inflammation and characterized by weight loss and skeletal muscle w...

    Authors: Wei-Chih Liao, Chih-Ta Chen, You-Shu Tsai, Xin-Ya Wang, Yen-Tzu Chang, Ming-Shiang Wu and Lu-Ping Chow
    Citation: BMC Cancer 2023 23:513
    Content type: Research Published on:

  32. Colorectal cancer (CRC) is the third most widespread cancer and the fourth leading lethal disease among different societies. It is thought that CRC accounts for about 10% of all newly diagnosed cancer cases wi...

    Authors: Marziyeh Sadat Moslehian, Roya Shabkhizan, Mohammad Reza Asadi, Ahad Bazmani, Mahdi Mahdipour, Sanya Haiaty, Reza Rahbarghazi and Ebrahim Sakhinia
    Citation: BMC Cancer 2023 23:512
    Content type: Research Published on:

  33. This study aimed to identify the biological functions, expression modes, and possible mechanisms underlying the relationship between metastatic human hepatocellular carcinoma (HCC) and MicroRNA-188-5p (miR-188...

    Authors: Yan-hui Wu, Bin Yu, Jiang-min Zhou, Xue-han Shen, Wei-xun Chen, Xi Ai, Chao Leng, Bin-yong Liang and Ya-jie Shao
    Citation: BMC Cancer 2023 23:511
    Content type: Research Published on:

  34. Uterine sarcoma is an uncommon aggressive malignancy. Optimal management and prognostic factors have yet to be well recognized due to their rarity and various histological subtypes. This study aims to investig...

    Authors: Saqib Raza Khan, Salman Muhammad Soomar, Tamana Asghari, Arsalan Ahmed and Munira Shabbir Moosajee
    Citation: BMC Cancer 2023 23:510
    Content type: Research Published on:

  35. E2F1 has been confirmed to be highly expressed in a variety of cancers. To better understand the prognostic value of E2F1 in cancer patients, this study was conducted to comprehensively evaluate the prognostic...

    Authors: Jingjing Li, Wen Bi, Fang Lu, Bei Pan, Mengqiu Xiong, Lubanga Nasifu, Zhenlin Nie and Bangshun He
    Citation: BMC Cancer 2023 23:509
    Content type: Research Published on:

  36. Benefit finding (BF) - the occurrence of positive life-changes in the aftermath of traumatic live events - has been repeatedly reported in prostate cancer (PCa) survivors, but it remains unclear in which way B...

    Authors: Matthias Jahnen, Patrick Bayer, Valentin H. Meissner, Stefan Schiele, Helga Schulwitz, Jürgen E. Gschwend, Kathleen Herkommer and Andreas Dinkel
    Citation: BMC Cancer 2023 23:508
    Content type: Research Published on:

  38. Osteosarcoma is the most common primary malignant bone tumor. The current study was conducted to describe the general condition of patients with primary osteosarcoma in a single cancer center in Tianjin, China...

    Authors: Chao Zhang, Haixiao Wu, Guijun Xu, Yao Xu, Wenjuan Ma, Zhijun Li and Jin Zhang
    Citation: BMC Cancer 2023 23:506
    Content type: Research Published on:

  39. The systemic inflammation score (SIS), based on serum albumin (Alb) and lymphocyte-to-monocyte ratio (LMR), is a novel prognostic tool for some tumours. Studies indicate that the SIS can be used as a postopera...

    Authors: Chunyue Huang, Mengyao Wang, Liwen Chen, Hongmei Wang, Donglan Huang, Jianjun Shi, Weijun Zhang, Yunhong Tian and Yujia Zhu
    Citation: BMC Cancer 2023 23:505
    Content type: Research Published on:

  40. Molecular subtypes predict prognosis in muscle-invasive bladder cancer (MIBC) and are explored as predictive markers. To provide a common base for molecular subtyping and facilitate clinical applications, a co...

    Authors: Florestan J. Koll, Claudia Döring, Csilla Olah, Tibor Szarvas, Jens Köllermann, Benedikt Hoeh, Felix K.-H. Chun, Henning Reis and Peter J. Wild
    Citation: BMC Cancer 2023 23:504
    Content type: Research Published on:

  44. Decisions to participate in cancer trials are associated with uncertainty, distress, wanting to help find a cure, the hope for benefit, and altruism. There is a gap in the literature regarding research examini...

    Authors: Lynn Corcoran, Christine M. Friedenreich, Margaret L. McNeely, Nicole S. Culos-Reed, Gordon Bell, Leanne Dickau, Kerry S. Courneya and Jeff K. Vallance
    Citation: BMC Cancer 2023 23:500
    Content type: Research Published on:

  45. Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and is notorious for its resistance to both chemotherapy and small-molecule inhibitor targeted therapies. Subcellular targeted c...

    Authors: Stefan Mrdenovic, Yanping Wang, Lijuan Yin, Gina Chia-Yi Chu, Yan Ou, Michael S. Lewis, Marija Heffer, Edwin M. Posadas, Haiyen E. Zhau, Leland W. K. Chung, Mouad Edderkaoui, Stephen J. Pandol, Ruoxiang Wang and Yi Zhang
    Citation: BMC Cancer 2023 23:499
    Content type: Research Published on:

  46. The frailty index (FI) is one way in which frailty can be quantified. While it is measured as a continuous variable, various cut-off points have been used to categorise older adults as frail or non-frail, and ...

    Authors: James A. Fletcher, Benignus Logan, Natasha Reid, Emily H. Gordon, Rahul Ladwa and Ruth E. Hubbard
    Citation: BMC Cancer 2023 23:498
    Content type: Research Published on:

  47. Cancer’s hallmark feature is its ability to evolve, leading to metastasis and recurrence. Although genetic mutations and epigenetic changes have been implicated, they don’t fully explain the leukocytic traits ...

    Authors: Mengtao Li, John R. Basile, Sanjay Mallya and Yi-Ling Lin
    Citation: BMC Cancer 2023 23:497
    Content type: Research Published on:

  48. Breast malignancies are now the most common and deadliest type of neoplasms among women worldwide. Novel therapeutic approaches are needed to combat advanced stages of breast cancer. In this study, we aimed to...

    Authors: Mohammadhossein Pournabee, Mahsa Keshavarz-Fathi, Pooyesh Esmaeili, Pouya Mahdavi Sharif, Fatemeh Nili and Behnaz Jahanbin
    Citation: BMC Cancer 2023 23:495
    Content type: Research Published on:

  49. Neuropeptide Y (NPY) is an abundant neurohormone in human breast carcinomas that acts on a class of G-protein coupled receptors, of which NPY1R and NPY5R are the most highly expressed. This abundance is exploi...

    Authors: Sydney A. Pascetta, Sarah M. Kirsh, Makenna Cameron and James Uniacke
    Citation: BMC Cancer 2023 23:494
    Content type: Research Published on:

  50. Over the past decade, therapeutic options in head and neck supraglottic squamous cell carcinoma have constantly evolved. The classical total laryngectomy has been partially replaced by alternative organ- and f...

    Authors: S. Hassid, B. Krug, S. Deheneffe, J-F. Daisne, G. Delahaut, G. Lawson, R. Crott and S. Van der Vorst
    Citation: BMC Cancer 2023 23:493
    Content type: Study Protocol Published on:

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