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  1. Galectin-9 is a member of the galectin family and has been reported to have a tumor-promoting or antitumor effect in response to the immune microenvironment. However, the immunomodulatory effect of galectin-9 ...

    Authors: Yang Wang, Ruizhi Zheng, Yanhui Zhang, Yuhong Guo, Zhenzhen Hui, Peijing Wang and Yan Sun
    Citation: BMC Cancer 2022 22:1319
    Content type: Research Published on:

  2. Large-scale trials have shown that hypofractionated adjuvant breast radiotherapy was as effective in terms of survival and local control as conventional fractionated radiotherapy, and acute toxicity was reduce...

    Authors: Marie Bruand, Julia Salleron, Sébastien Guihard, Charles Marchand Crety, Xavier Liem, David Pasquier, Assia Lamrani-Ghaouti, Claire Charra-Brunaud, Didier Peiffert, Jean-Baptiste Clavier, Emmanuel Desandes and Jean-Christophe Faivre
    Citation: BMC Cancer 2022 22:1318
    Content type: Research Published on:

  3. To explore the value of preoperative prognostic immune and nutritional index (PINI) in predicting postoperative complications and long-term outcomes in patients with stage I–III colorectal cancer (CRC).

    Authors: Hailun Xie, Lishuang Wei, Mingxiang Liu, Yanren Liang, Guanghui Yuan, Shunhui Gao, Qiwen Wang, Xin Lin, Shuangyi Tang and Jialiang Gan
    Citation: BMC Cancer 2022 22:1316
    Content type: Research Published on:

  5. Cancer chemotherapy indications for patients with poor performance status and advanced lung cancer are limited. Molecular targeted drugs, including epidermal growth factor receptor (EGFR)-tyrosine kinase inhib...

    Authors: Tomoya Fukui, Jiichiro Sasaki, Satoshi Igawa, Akiko Kada, Toshiki I. Saito, Yoshihito Kogure, Hiroaki Okamoto and Katsuhiko Naoki
    Citation: BMC Cancer 2022 22:1314
    Content type: Study protocol Published on:

  6. Prostate cancer is a major health issue affecting the male population worldwide, and its etiology remains relatively unknown. As presented on the Gene Expression Profiling Interactive Analysis database, acetyl...

    Authors: Jingqian Guan, Xizi Jiang, Yaoxing Guo, Wenhui Zhao, Ji Li, Yizhuo Li, Ming Cheng, Lin Fu, Yue Zhao and Qingchang Li
    Citation: BMC Cancer 2022 22:1313
    Content type: Research Published on:

  7. We describe the association between initial treatment and end-of-life (EOL) outcomes among patients with pancreatic ductal adenocarcinoma (PDAC).

    Authors: Rishad Khan, Misbah Salim, Peter Tanuseputro, Amy T. Hsu, Natalie Coburn, Julie Hallet, Robert Talarico and Paul D. James
    Citation: BMC Cancer 2022 22:1312
    Content type: Research Published on:

  8. This study aimed to develop an innovative inflammation-nutrition biomarker score (INS) system to stratify the prognoses of patients with cancer.

    Authors: Hailun Xie, Guotian Ruan, Lishuang Wei, Heyang Zhang, Qi Zhang, Yizhong Ge, Shiqi Lin, Mengmeng Song, Xi Zhang, Xiaoyue Liu, Xiaowei Zhang, Xiangrui Li, Kangping Zhang, Ming Yang, Meng Tang, Li Deng…
    Citation: BMC Cancer 2022 22:1311
    Content type: Research Published on:

  9. We evaluated the performance of single-nucleotide polymorphism (SNP) genotyping arrays OncoScan (Thermo Fisher Scientific, San Diego, CA) and Infinium CytoSNP-850K (CytoSNP; Illumina, Waltham, MA) for assessin...

    Authors: Razvan Cristescu, Xiao Qiao Liu, Gladys Arreaza, Cai Chen, Andrew Albright, Ping Qiu and Matthew J. Marton
    Citation: BMC Cancer 2022 22:1310
    Content type: Research Published on:

  10. In many middle-income countries, cancer incidence and mortality are rapidly increasing, but data for developing a strategy of cancer control are rarely collected or analyzed. This study aimed to identify facto...

    Authors: Lady Margaretha Febriany Sirait, Nobuyuki Hamajima, Yunosuke Suzuki, Endang Sri Wahyuningsih, Dwi Oktavia, Widyastuti, Souphalak Inthaphatha, Kimihiro Nishino and Eiko Yamamoto
    Citation: BMC Cancer 2022 22:1309
    Content type: Research Published on:

  11. The discovery of the importance of the immune system and its role in oncogenesis led to the development of immunotherapy, a treatment that represents a major advance in oncology management. Due to the recent n...

    Authors: Marie Lange, Bénédicte Clarisse, Alexandra Leconte, Kléouforo-Paul Dembélé, Justine Lequesne, Celeste Nicola, Martine Dubois, Laurence Derues, Yori Gidron, Hélène Castel and Florence Joly
    Citation: BMC Cancer 2022 22:1308
    Content type: Study protocol Published on:

  12. Extrahepatic disease progression limits clinical efficacy of Yttrium-90 (90Y) radioembolization (TARE) for patients with chemotherapy-refractory metastatic colorectal cancer (mCRC). Trifluridine and tipiracil (TA...

    Authors: Nicholas Fidelman, Chloe E. Atreya, Madeline Griffith, M. Alexandra Milloy, Julia Carnevale, Pelin Cinar, Alan P. Venook and Katherine Van Loon
    Citation: BMC Cancer 2022 22:1307
    Content type: Research Published on:

  13. The safety and short-term outcomes of gastrectomy after preoperative chemotherapy plus immunotherapy (PCIT) versus preoperative chemotherapy (PCT) in patients with advanced gastric cancer (AGC) remain unclear....

    Authors: Yinkui Wang, Xiaokang Lei, Fei Shan, Shuangxi Li, Yongning Jia, Rulin Miao, Kan Xue, Zhemin Li, Jiafu Ji and Ziyu Li
    Citation: BMC Cancer 2022 22:1306
    Content type: Research Published on:

  14. Separating benign from malignant soft-tissue masses often requires a biopsy. The objective of this study was to assess whether shear-wave elastography (SWE) helped to separate benign from malignant soft-tissue...

    Authors: Sylvain Bodard, Louis Lassalle, Frédérique Larousserie, Sylvain Guinebert, Thomas Hacquart, Raphael Campagna, David Biau, Noreddine Regnard and Antoine Feydy
    Citation: BMC Cancer 2022 22:1305
    Content type: Research Published on:

  15. Esophageal squamous cell carcinoma (ESCC) remains one of the most lethal cancers worldwide accompany with an extremely poor prognosis. Therefore, this study aims to screen for new molecules affecting ESCC and ...

    Authors: Yanqun Liu, Rong Xiong, Ting Xiao, Li Xiong, Jialin Wu, Junfeng Li, Gang Feng, Guiqin Song and Kang Liu
    Citation: BMC Cancer 2022 22:1304
    Content type: Research Published on:

  16. The coronavirus disease 2019 (COVID-19) pandemic has rapidly and dramatically influenced healthcare across Japan. However, the influence of the COVID-19 pandemic on the number of newly diagnosed cancer, surgic...

    Authors: Takeshi Terashima, Hiroshi Konishi, Yasunori Sato, Muneki Igarashi, Takafumi Yanagibashi, Ryo Konno, Hideyuki Saya, Yuichiro Doki and Tadao Kakizoe
    Citation: BMC Cancer 2022 22:1303
    Content type: Research Published on:

  17. Ripretinib is a novel switch-control kinase inhibitor that inhibits KIT and PDGFRA signaling. In the INVICTUS phase 3 trial, ripretinib increased median progression-free survival and prolonged overall survival...

    Authors: Patrick Schöffski, Suzanne George, Michael C. Heinrich, John R. Zalcberg, Sebastian Bauer, Hans Gelderblom, César Serrano, Robin L. Jones, Steven Attia, Gina D’Amato, Ping Chi, Peter Reichardt, Claus Becker, Kelvin Shi, Julie Meade, Rodrigo Ruiz-Soto…
    Citation: BMC Cancer 2022 22:1302
    Content type: Research Published on:

  18. Neoadjuvant chemotherapy (NAC) before radical cystectomy is associated with pathological downstaging (DS) and improved overall survival (OS) in patients with muscle-invasive bladder cancer (MIBC). Population-b...

    Authors: Christina Tanem Møller, Nathalie C. Støer, Augun Blindheim, Viktor Berge, Gunnar Tafjord, Sophie D. Fosså and Bettina Kulle Andreassen
    Citation: BMC Cancer 2022 22:1301
    Content type: Research Published on:

  20. Many screening programs for colorectal cancer (CRC) use the fecal immunochemical test (FIT) to triage individuals for colonoscopy. Although these programs reduce CRC incidence and CRC-related mortality, the de...

    Authors: P. H. A. Wisse, W. de Klaver, F. van Wifferen, L. Meiqari, M. Bierkens, M. J. E. Greuter, B. Carvalho, M. E. van Leerdam, M. C. W. Spaander, E. Dekker, V. M. H. Coupé, M. de Wit and G. A. Meijer
    Citation: BMC Cancer 2022 22:1299
    Content type: Study protocol Published on:

  21. Metaplastic breast cancer (MpBC) is an aggressive subtype of breast carcinoma that is often resistant to conventional chemotherapy. Therefore, novel treatment strategies are urgently needed. Immune check point...

    Authors: S. Voutilainen, P. Heikkilä, J. Bartkova, H. Nevanlinna, C. Blomqvist, J. Bartek and J. Mattson
    Citation: BMC Cancer 2022 22:1298
    Content type: Research article Published on:

  22. Juvenile Pilocytic Astrocytomas (JPAs) are one of the most common pediatric brain tumors, and they are driven by aberrant activation of the mitogen-activated protein kinase (MAPK) signaling pathway. RAF-fusions a...

    Authors: Melissa Zwaig, Audrey Baguette, Bo Hu, Michael Johnston, Hussein Lakkis, Emily M. Nakada, Damien Faury, Nikoleta Juretic, Benjamin Ellezam, Alexandre G. Weil, Jason Karamchandani, Jacek Majewski, Mathieu Blanchette, Michael D. Taylor, Marco Gallo, Claudia L. Kleinman…
    Citation: BMC Cancer 2022 22:1297
    Content type: Research article Published on:

  23. Intrahepatic cholangiocarcinoma (CCA) is amongst the most common primary liver tumors worldwide. CCA carries a bad prognosis prompting research to establish new treatment modalities other than surgery and the ...

    Authors: Charbel Elias, Youssef H. Zeidan, Youssef Bouferraa, Deborah Mukherji, Sally Temraz, Maya Charafeddine, Monita Al Darazi and Ali Shamseddine
    Citation: BMC Cancer 2022 22:1296
    Content type: Study protocol Published on:

  24. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) combined with cytotoxic chemotherapy are highly effective in the treatment of advanced non–small-cell lung cancer (NSCLC) with EGFR mutat...

    Authors: Kai Shang, Hongxiang Huang, Yongkang Xu, Yangyang Liu, Zhihui Lu and Li Chen
    Citation: BMC Cancer 2022 22:1295
    Content type: Research article Published on:

  25. Metastasis-directed therapy (MDT) significantly delays the initiation of palliative androgen deprivation therapy (pADT) in patients with oligorecurrent prostate cancer (PCa) with a positive impact on patient’s...

    Authors: Kato Rans, Berghen Charlien, Ameye Filip, De Hertogh Olivier, den Hartog Julie, Draulans Céderic, Dumez Herlinde, Engels Benedikt, Goffin Karolien, Laenen Annouschka, Liefhooghe Nick, Poels Kenneth, Salembier Carl, Slabbaert Koen, Vandendriessche Hans, Vanneste Ben…
    Citation: BMC Cancer 2022 22:1294
    Content type: Study protocol Published on:

  26. Although the human papillomavirus (HPV) vaccine has been recommended in Germany for girls since 2007, no organised vaccination programme was introduced and HPV vaccine coverage remains low. We investigated the...

    Authors: Vanesa Osmani, Sandra Fett, Martin Tauscher, Ewan Donnachie, Antonius Schneider and Stefanie J. Klug
    Citation: BMC Cancer 2022 22:1293
    Content type: Research article Published on:

  27. Previous clinical trials have demonstrated the potential efficacy of poly (ADP-ribose) polymerase (PARP) inhibitors (PARPis) in patients with cancer involving homologous recombination repair (HRR) gene-mutatio...

    Authors: Taigo Kato, Nobuaki Matsubara, Masaki Shiota, Masatoshi Eto, Takahiro Osawa, Takashige Abe, Nobuo Shinohara, Yota Yasumizu, Nobuyuki Tanaka, Mototsugu Oya, Koshiro Nishimoto, Takuji Hayashi, Masashi Nakayama, Takahiro Kojima, Kenjiro Namikawa, Takao Fujisawa…
    Citation: BMC Cancer 2022 22:1292
    Content type: Study protocol Published on:

  29. Metabolic reprogramming is a hallmark of cancer, alteration of nucleotide metabolism of hepatocellular carcinoma (HCC) is not well-understood. MYBL2 regulates cell cycle progression and hepatocarcinogenesis, i...

    Authors: Jun-Zhang Zhao, Wei Wang, Tao Liu, Lei Zhang, De-Zheng Lin, Jia-Yin Yao, Xiang Peng, Gang Jin, Tian-Tian Ma, Jin-Bo Gao, Fang Huang, Jun Nie and Qing Lv
    Citation: BMC Cancer 2022 22:1290
    Content type: Research Published on:

  30. Prostate cancer (PrCa) is one of the most genetically driven solid cancers with heritability estimates as high as 57%. Men of African ancestry are at an increased risk of PrCa; however, current polygenic risk ...

    Authors: Meghana S. Pagadala, Joshua A. Linscott, James V. Talwar, Tyler M. Seibert, Brent Rose, Julie Lynch, Matthew Panizzon, Richard Hauger, Moritz H. Hansen, Jesse D. Sammon, Matthew H. Hayn, Karim Kader, Hannah Carter and Stephen T. Ryan
    Citation: BMC Cancer 2022 22:1289
    Content type: Research article Published on:

  31. The purpose was to provide a practical and effective method for performing reliable 90Y dosimetry based on 99mTc-MAA and SPEC/CT. The impact of scatter correction (SC) and attenuation correction (AC) on the injec...

    Authors: Mohammad Abuqbeitah, Özgür Taylan Akdağ, Mustafa Demir, Sertaç Asa and Kerim Sönmezoğlu
    Citation: BMC Cancer 2022 22:1288
    Content type: Research Published on:

  33. The complications of radical surgery for cervical cancer can increase patient suffering and affect their quality of life. This retrospective study assessed the safety of radical hysterectomy (RH) with pelvic l...

    Authors: Huang Jing, Wu Xiuhong, Yu Ying, Cheng Xiyun, Luo Deping, Shen Changmei, Wang Qi, Peng Tao and Pan Yiyun
    Citation: BMC Cancer 2022 22:1286
    Content type: Research Published on:

  34. Evaluation of treated tumors according to Response Evaluation Criteria in Solid Tumors (RECIST) criteria is an important but time-consuming task in medical imaging. Deep learning methods are expected to automa...

    Authors: Xiang Liu, Rui Wang, Zemin Zhu, Kexin Wang, Yue Gao, Jialun Li, Yaofeng Zhang, Xiangpeng Wang, Xiaodong Zhang and Xiaoying Wang
    Citation: BMC Cancer 2022 22:1285
    Content type: Research Published on:

  36. As the main isoforms of membranous glucose transporters (GLUT), GLUT1 involves tumorigenesis, metastasis and prognosis in a variety of cancers. However, its role in breast cancer metastasis remains to be eluci...

    Authors: Ping Zhu, Guoping Liu, Xue Wang, Jingjing Lu, Yue Zhou, Shuyi Chen, Yabiao Gao, Chaofu Wang, Jerry Yu, Yangbai Sun and Ping Zhou
    Citation: BMC Cancer 2022 22:1283
    Content type: Research Published on:

  37. Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal develop...

    Authors: Hassan Yousefi, Afshin Bahramy, Narges Zafari, Mahsa Rostamian Delavar, Khoa Nguyen, Atousa Haghi, Tahmineh Kandelouei, Cecilia Vittori, Parham Jazireian, Sajad Maleki, Danyal Imani, Amin Moshksar, Amirreza Bitaraf and Sadegh Babashah
    Citation: BMC Cancer 2022 22:1282
    Content type: Research Published on:

  38. The Tn antigen (CD175) is an O-glycan expressed in various types of human adenocarcinomas, including colorectal cancer (CRC), though prior studies have relied heavily upon poorly characterized in-house generat...

    Authors: Gabrielle E. Dombek, Ana Sofia Ore, Jane Cheng, Yasuyuki Matsumoto, Jonathan N. Glickman, Aaron Fleishman, Jamie Heimburg-Molinaro, Vitaliy Y. Poylin, Anne Fabrizio, Thomas Cataldo, Evangelos Messaris and Richard D. Cummings
    Citation: BMC Cancer 2022 22:1281
    Content type: Research Published on:

  39. Histological grade has been demonstrated to be an important factor of breast cancer outcome and is associated with cell differentiation and is currently being evaluated via H&E-stained sections. Molecular biom...

    Authors: Mei Li, Yanan Zheng, Xujun Li, Xiaohan Shen, Tingxia Zhang, Bowen Weng, Haijiao Mao and Jiyuan Zhao
    Citation: BMC Cancer 2022 22:1280
    Content type: Research Published on:

  40. In India, breast and cervical cancers account for two-fifths of all cancers and are predominantly prevalent among women in the reproductive age group. The Government of India recommended screening of breast an...

    Authors: Soumendu Sen, Pijush Kanti Khan, Tabassum Wadasadawala and Sanjay K Mohanty
    Citation: BMC Cancer 2022 22:1279
    Content type: Research Published on:

  41. Prostate-specific membrane antigen (PSMA) overexpression has been observed in the endothelial neovasculature of several solid malignancies. This study aimed to identify PSMA expression in the primary tumor of ...

    Authors: Young Jae Ryu, Soo Young Lim, Yong Min Na, Min Ho Park, Seong Young Kwon and Ji Shin Lee
    Citation: BMC Cancer 2022 22:1278
    Content type: Research Published on:

  42. Speckle-type POZ protein(SPOP), a substrate adaptor of Cul3 ubiquitin ligase, plays crucial roles in solid neoplasms by promoting the ubiquitination and degradation of substrates. Limited studies have shown th...

    Authors: Zhi Chen, Zuan Li, Chunlin Li, Bingcai Li, Haojian Wang, Deyong Nong, Ximing Li, Guihai Huang, Junhao Lin and Wei Li
    Citation: BMC Cancer 2022 22:1277
    Content type: Research Published on:

  43. Nonalcoholic fatty liver disease affects about 24% of the world’s population and may progress to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma (HCC). While more common in those t...

    Authors: Emma Hymel, Kurt W. Fisher and Paraskevi A. Farazi
    Citation: BMC Cancer 2022 22:1276
    Content type: Research Published on:

  44. This study constructs a lung cancer risk index (LCRI) that incorporates many modifiable risk factors using an easily reproducible and adaptable method that relies on publicly available data.

    Authors: Ali Faghani, Lei Guo, Margaret E. Wright, M. Courtney Hughes and Mahdi Vaezi
    Citation: BMC Cancer 2022 22:1275
    Content type: Research Published on:

  45. This study aimed to use single-cell RNA-seq (scRNA-seq) to discover marker genes in endothelial cells (ECs) and construct a prognostic model for glioblastoma multiforme (GBM) patients in combination with tradi...

    Authors: Songyun Zhao, Wei Ji, Yifan Shen, Yuansheng Fan, Hui Huang, Jin Huang, Guichuan Lai, Kemiao Yuan and Chao Cheng
    Citation: BMC Cancer 2022 22:1274
    Content type: Research Published on:

  47. Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers worldwide. Overexpression of EMT master transcription factors can promote differentiated cells to undergo cancer reprogramming processe...

    Authors: Sima Ardalan Khales, Sina Mozaffari-Jovin, Dirk Geerts and Mohammad Reza Abbaszadegan
    Citation: BMC Cancer 2022 22:1272
    Content type: Research Published on:

  48. Age is an independent prognostic factor for small cell lung cancer (SCLC). We aimed to construct a nomogram survival prediction for elderly SCLC patients based on the Surveillance, Epidemiology, and End Result...

    Authors: Guangrong Lu, Jiajia Li, Yejiao Ruan, Yuning Shi, Xuchao Zhang, Yushan Xia, Zheng Zhu, Jiafeng Lin and Lili Li
    Citation: BMC Cancer 2022 22:1271
    Content type: Research Published on:

  49. The role of the immune system in locally advanced rectal cancer (LARC) following preoperative chemoradiotherapy (CRT) has been widely investigated in recent years. This study examined the prognostic significan...

    Authors: Chie Takasu, Masaaki Nishi, Kozo Yoshikawa, Takuya Tokunaga, Toshihiro Nakao, Hideya Kashihara, Yuma Wada, Toshiaki Yoshimoto, Shohei Okikawa, Shoko Yamashita and Mitsuo Shimada
    Citation: BMC Cancer 2022 22:1263
    Content type: Research article Published on:

  50. Radiobiological daily changes within tumors are considered to be quite different between stereotactic radiotherapy (SRT) (e.g., 50 Gy in 4 fractions) and conventional radiotherapy (e.g., 60 Gy in 30 fractions)...

    Authors: Natsuo Tomita, Hiromichi Ishiyama, Chiyoko Makita, Yukihiko Ohshima, Aiko Nagai, Fumiya Baba, Mayu Kuno, Shinya Otsuka, Takuhito Kondo, Chikao Sugie, Tatsuya Kawai, Taiki Takaoka, Dai Okazaki, Akira Torii, Masanari Niwa, Nozomi Kita…
    Citation: BMC Cancer 2022 22:1259
    Content type: Study protocol Published on:

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