Skip to main content

Articles

Page 4 of 312

  1. Glioblastoma patients commonly develop resistance to temozolomide chemotherapy. Hypoxia, which supports chemotherapy resistance, favors the expansion of glioblastoma stem cells (GSC), contributing to tumor rel...

    Authors: Nadia Sousa, Carsten Geiß, Laura Bindila, Ingo Lieberwirth, Ella Kim and Anne Régnier-Vigouroux
    Citation: BMC Cancer 2023 23:762
    Content type: Research Published on:

  3. Lung cancer is reported to be the leading cause of death in males and females, globally. Increasing evidence highlights the paramount importance of Lactate dehydrogenase D (LDHD) in different types of cancers,...

    Authors: Yu Zhang, Tianyi Zhang, Yingdong Zhao, Hongdi Wu, Qiang Zhen, Suwei Zhu and Shaoshuai Hou
    Citation: BMC Cancer 2023 23:759
    Content type: Research Published on:

  6. This project aimed to research the significance of THRIL in the diagnosis of benign and malignant solitary pulmonary nodules (SPNs) and to investigate the role of THRIL/miR-99a in malignant SPNs.

    Authors: Xinyu Chen, Xianji Zhu, Wenjun Yan, Luan Wang, Dongming Xue, Shouying Zhu, Jiajun Pan, Yufeng Li, Qixiang Zhao and Dong Han
    Citation: BMC Cancer 2023 23:755
    Content type: Research Published on:

  7. Spatial analysis can identify communities where men are at risk for aggressive prostate cancer (PCan) and need intervention. However, there are several definitions for aggressive PCan. In this study, we evalua...

    Authors: Daniel Wiese, Tesla D. DuBois, Kristen A. Sorice, Carolyn Y. Fang, Camille Ragin, Mary B. Daly, Adam C. Reese, Kevin A. Henry and Shannon M. Lynch
    Citation: BMC Cancer 2023 23:754
    Content type: Research Published on:

  8. Small-cell lung cancer (SCLC) is a highly aggressive and lethal malignancy that accounts for 10–15% of lung cancers, and it is generally divided into limited and extensive stage. The standard of care for patie...

    Authors: Deyu Li, Zhangzhou Huang, Jiangming Zhong, Li Lin, Guifeng Zhang, Wu Zhuang and Zhenhua Liu
    Citation: BMC Cancer 2023 23:753
    Content type: Study protocol Published on:

  9. An increasing amount of research has speculated that necroptosis could be a therapeutic strategy for treating cancer. However, understanding the prognostic value of the necroptosis-related long non-coding RNAs...

    Authors: Jianlan Liu, Binlin Luo, Pengpeng Zhang, Keyu Jiang, Zuoqiong Hou, Xiaojian Cao and Jian Tang
    Citation: BMC Cancer 2023 23:752
    Content type: Research Published on:

  10. This study aims to investigate the predictive value of the combined index smni(skeletal muscle index (SMI)-prognostic nutrition index(PNI)) for the postoperative survival of patients with advanced gastric canc...

    Authors: Yubo Han, Ju Wu, Rui Ji, Hao Tan, Simiao Tian, Jiajun Yin, Jian Xu, Xi Chen, Wenfei Liu and Hongzhang Cui
    Citation: BMC Cancer 2023 23:751
    Content type: Research Published on:

  11. 3D culture is increasingly used in cancer research, as it allows the growth of cells in an environment that mimics in vivo conditions. Metastases are the primary cause of morbidity and mortality in cancer pati...

    Authors: Erika Naakka, Wafa Wahbi, Riia Tiikkaja, Krista Juurikka, Toni Sandvik, Petri Koivunen, Timo Autio, Jukka Tikanto, Janne Väisänen, Hannu Tuominen, Anne Talvensaari-Mattila, Ahmed Al-Samadi, Rabah Soliymani, Pirjo Åström, Maija Risteli and Tuula Salo
    Citation: BMC Cancer 2023 23:750
    Content type: Research Published on:

  12. Glioblastoma (GBM) is a type of highly malignant brain tumor that is known for its significant intratumoral heterogeneity, meaning that there can be a high degree of variability within the tumor tissue. Despit...

    Authors: Nannan Zhao, Siyuan Weng, Zaoqu Liu, Hui Xu, Yuqin Ren, Chunguang Guo, Long Liu, Zhenyu Zhang, Yuchen Ji and Xinwei Han
    Citation: BMC Cancer 2023 23:749
    Content type: Research Published on:

  13. Patients with advanced pancreatic cancer have a poor prognosis and high burden of cancer-related symptoms. It is necessary to assess the trade-off of clinical benefits and possible harms of treatments with ant...

    Authors: Josefina Salazar, Javier Bracchiglione, Olga Savall-Esteve, Alba Antequera, David Bottaro-Parra, Marta Gutiérrez-Valencia, Susana Martínez-Peralta, Carles Pericay, Ariadna Tibau and Xavier Bonfill
    Citation: BMC Cancer 2023 23:748
    Content type: Research Published on:

  14. Lung cancer is the third most common type of cancer in the UK. Treatment outcomes are poor and UK deaths from lung cancer are higher than any other cancer. Prehabilitation has shown to be an important means of...

    Authors: Kelly Wade-Mcbane, Alex King, Catherine Urch, Julian Jeyasingh-Jacob, Andrew Milne and Clair Le Boutillier
    Citation: BMC Cancer 2023 23:747
    Content type: Research Published on:

  15. This study aimed to compare the efficacy and safety of high-dose methotrexate (HD-MTX) versus teniposide (TEN) in patients with newly diagnosed immunocompetent primary central nervous system lymphomas (PCNSLs).

    Authors: Kaili Zhong, Yanyan Shi, Yuhuan Gao, Huilai Zhang, Mingzhi Zhang, Qiaohua Zhang, Xinan Cen, Mei Xue, Yan Qin, Yu Zhao, Liling Zhang, Rong Liang, Ningju Wang, Yan Xie, Yu Yang, Aichun Liu…
    Citation: BMC Cancer 2023 23:746
    Content type: Research Published on:

  17. ‘Prehabilitation’ interventions aim to enhance individuals’ physical fitness prior to cancer treatment, typically involve exercise training as a key component, and may continue to support physical activity, st...

    Authors: Rachael Powell, Amy Davies, Kirsty Rowlinson-Groves, David P French, John Moore and Zoe Merchant
    Citation: BMC Cancer 2023 23:744
    Content type: Research Published on:

  18. The prognostic role of either forkhead box A1 (FOXA1) or anterior gradient 2 (AGR2) in breast cancer has been found separately. Considering that there were interplays between them depending on ER status, we ai...

    Authors: Meng Zhou, Xing-li Gan, Yue-xiang Ren, Qian-xin Chen, Yuan-zhong Yang, Zi-jin Weng, Xiao-fang Zhang, Jie-xia Guan, Lu-ying Tang and Ze-fang Ren
    Citation: BMC Cancer 2023 23:743
    Content type: Research Published on:

  19. Bone sarcomas are rare tumors representing 0.2% of all cancers. While osteosarcoma and Ewing sarcoma mainly affect children and young adults, chondrosarcoma and chordoma have a preferential incidence in people...

    Authors: Marie-Anaïs Locquet, Mehdi Brahmi, Jean-Yves Blay and Aurélie Dutour
    Citation: BMC Cancer 2023 23:742
    Content type: Review Published on:

  20. SPOCK3 is a secreted extracellular matrix proteoglycan. This study aimed to investigate the effect of SPOCK3 on the malignant progression of prostate cancer and to construct a prognostic model to predict DFS o...

    Authors: Jiawen Luo, Cong Lai, Xiaoting Xu, Juanyi Shi, Jintao Hu, Kaixuan Guo, Yelisudan Mulati, Yunfei Xiao, Degeng Kong, Cheng Liu and Kewei Xu
    Citation: BMC Cancer 2023 23:741
    Content type: Research Published on:

  21. Authors: Farastuk Bozorgmehr, Inn Chung, Petros Christopoulos, Johannes Krisam, Marc A. Schneider, Lena Brückner, Daniel Wilhelm Mueller, Michael Thomas and Stefan Rieken
    Citation: BMC Cancer 2023 23:740
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2020 20:806

  22. Thyroid cancer (TC) overall survival at 5 years was estimated at 97% in mainland France over 2010–2015. Its prognosis is known to be affected by patient age, tumor histology, size, and extension. This study ai...

    Authors: Lyvio Lin, Thierry Almont, Murielle Beaubrun, Jonathan Macni, Aimée Pierre-Louis, Audrey Zabulon, Ciprian Draganescu, Lucien Lin, Nadia Sabbah, Moustapha Drame, Jacqueline Veronique-Baudin and Clarisse Joachim
    Citation: BMC Cancer 2023 23:739
    Content type: Research Published on:

  23. Genetic screening for pathogenic variants (PVs) in cancer predisposition genes can affect treatment strategies, risk prediction and preventive measures for patients and families. For decades, hereditary breast...

    Authors: Anna Öfverholm, Therese Törngren, Anna Rosén, Brita Arver, Zakaria Einbeigi, Karin Haraldsson, Anne Kinhult StÃ¥hlbom, Ekaterina Kuchinskaya, Annika Lindblom, Beatrice Melin, Ylva Paulsson-Karlsson, Marie Stenmark-Askmalm, Emma Tham, Anna von Wachenfeldt, Anders Kvist, Ã…ke Borg…
    Citation: BMC Cancer 2023 23:738
    Content type: Research article Published on:

  24. In advanced Renal Cell Carcinoma (aRCC), systemic therapy is the mainstay of treatment, with no or little role for surgery in these patients. Tyrosine kinase inhibitors (TKIs) and immune-oncological (IOs) ther...

    Authors: Tarini Prasad Sahoo, Chirag Desai, Shyam Agarwal, Amit Rauthan, Boman Dhabhar, Ghanshyam Biswas, Sandeep Batra, Rajat Saha, Arun Philip, Vijay Agarwal, Palanki Satya Dattatreya, PN Mohapatra, Chetan Deshmukh, Sagar Bhagat, Saiprasad Patil and Hanmant Barkate
    Citation: BMC Cancer 2023 23:737
    Content type: Research Published on:

  25. Non-metastatic breast cancer treatment is mainly based on surgery, with or without chemotherapy, radiotherapy and/or hormone therapy. To reduce the risk of hormone receptor positive (HR+) disease recurrence, h...

    Authors: François Gernier, Jean-Michel Grellard, Charlotte Dupont, Hervé Castel, Marie Fernette, François Lahaye, Rose-Marie Charles, Tiphaine Leroux, Céline Ory, Audrey Faveyrial, Adeline Morel, George Emile, Christelle Levy, Carine Segura, Djelila Allouache, Alison Johnson…
    Citation: BMC Cancer 2023 23:736
    Content type: Study Protocol Published on:

  26. The centromere protein O (CENPO) is an important member of the centromere protein family. However, the role of CENPO in pan–cancer and immune infiltration has not been reported. Here, we investigated the role ...

    Authors: Yuanbiao Wang, Daowen Ye, Ying Li, Fenghong Lv, Wanbo Shen, Hui Li, Linghan Tian, Zongling Fan, Yanling Li, Yan wang, Feng Li and Yan Chen
    Citation: BMC Cancer 2023 23:735
    Content type: Research Published on:

  27. For locally advanced rectal cancer (LARC), total neoadjuvant therapy (TNT) may enhance tumour response, reduce recurrence, and improve patient compliance compared to upfront surgery. Recent studies have shown ...

    Authors: Min Jung Kim, Dae Won Lee, Hyun-Cheol Kang, Ji Won Park, Seung-Bum Ryoo, Sae-Won Han, Kyung Su Kim, Eui Kyu Chie, Jae Hwan Oh, Woon Kyung Jeong, Byoung Hyuck Kim, Eun Mi Nam and Seung-Yong Jeong
    Citation: BMC Cancer 2023 23:734
    Content type: Study Protocol Published on:

  28. Histone acetylation (HA) is an important and common epigenetic pathway, which could be hijacked by tumor cells during carcinogenesis and cancer progression. However, the important role of HA across human cance...

    Authors: Congkuan Song, Xinfei Liu, Weichen Lin, Kai Lai, Shize Pan, Zilong Lu, Donghang Li, Ning Li and Qing Geng
    Citation: BMC Cancer 2023 23:733
    Content type: Research Published on:

  29. Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation often obtain de novo resistance or develop secondary resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs), wh...

    Authors: Yaya Yu, Zhenzhen Xiao, Chenjing Lei, Changju Ma, Lina Ding, Qing Tang, Yihan He, Yadong Chen, Xuesong Chang, Yanjuan Zhu and Haibo Zhang
    Citation: BMC Cancer 2023 23:732
    Content type: Research Published on:

  30. To assess the cost-effectiveness of cetuximab in combination with chemotherapy fluorouracil, oxaliplatin, and leucovorin (FOLFOX) or fluorouracil, irinotecan and leucovorin (FOLFIRI) compared to standard chemo...

    Authors: Septiara Putri, Siti Rizny F. Saldi, Levina Chandra Khoe, Ery Setiawan, Amila Megraini, Benjarin Santatiwongchai, Ryan R. Nugraha, Vetty Y. Permanasari, Mardiati Nadjib, Sudigdo Sastroasmoro and Armansyah Armansyah
    Citation: BMC Cancer 2023 23:731
    Content type: Research Published on:

  31. Cervical cancer (CC) can be prevented through early detection facilitated by screening as well as an early diagnosis and effective treatment of the precancerous lesions. The present research aimed to determine...

    Authors: Sara Dadipoor, Azin Alavi, Zainab Kader, Shokrollah Mohseni, Hadi Eshaghi Sani Kakhaki and Nahid Shahabi
    Citation: BMC Cancer 2023 23:730
    Content type: Research Published on:

  32. Biliary tract cancer (BTC) is a relatively rare but highly aggressive malignancy. However, there is currently no satisfactory second-line regimen for patients without specific genetic mutations. Nanoparticle a...

    Authors: Nan Zhou, Xiaofen Li, Yu Yang, Sirui Tan, Shunyu Zhang, Qiyue Huang and Hongfeng Gou
    Citation: BMC Cancer 2023 23:729
    Content type: Study Protocol Published on:

  33. Surgical resection followed by adjuvant mFOLFIRINOX (5-fluorouracil with leucovorin, irinotecan, and oxaliplatin) is currently the standard of care for patients with resectable pancreatic cancer. The main conc...

    Authors: J. L. van Dam, E. M. M. Verkolf, E. N. Dekker, B. A. Bonsing, S. O. Bratlie, L. A. A. Brosens, O. R. Busch, L. M. J. W. van Driel, C. H. J. van Eijck, S. Feshtali, P. Ghorbani, D. J. A. de Groot, J. W. B. de Groot, B. C. M. Haberkorn, I. H. de Hingh, B. van der Holt…
    Citation: BMC Cancer 2023 23:728
    Content type: Study Protocol Published on:

  34. Low grade glioma (LGG) is considered a heterogeneous tumor with highly variable survival and limited efficacy of immunotherapy. To identify high-risk subsets and apply immunotherapy effectively in LGG, the sta...

    Authors: Jinna Li, Qing Guo and Rui Xing
    Citation: BMC Cancer 2023 23:727
    Content type: Research Published on:

  35. Trifluridine/tipiracil (FTD/TPI) prolongs survival in the third- or later-line treatment for advanced gastric cancer (GC), esophagogastric junction (EGJ) adenocarcinoma, and colorectal cancer. While single-arm...

    Authors: Naoki Takahashi, Hiroki Hara, Kengo Nagashima, Kenro Hirata, Toshiki Masuishi, Toshihiko Matsumoto, Hisato Kawakami, Kentaro Yamazaki, Shuichi Hironaka, Narikazu Boku and Kei Muro
    Citation: BMC Cancer 2023 23:726
    Content type: Study Protocol Published on:

  36. Bladder cancer (BLCA) represents a highly heterogeneous disease characterized by distinct histological, molecular, and clinical features, whose tumorigenesis and progression require aberrant metabolic reprogra...

    Authors: Yun Cai, Yifei Cheng, Ziyu Wang, Lu Li, Zhengtao Qian, Wei Xia and Weiwei Yu
    Citation: BMC Cancer 2023 23:725
    Content type: Research Published on:

  37. Current radiotherapy guidelines and consensus statements uniformly recommend elective region irradiation (ERI) as the standard strategy for nasopharyngeal carcinoma (NPC). However, given the scarcity of skip-m...

    Authors: Yang Liu, Yaqian Han, Feng Liu, Desheng Hu, Zhijian Chen, Peiguo Wang, Jingao Li, Jiyong Qin, Feng Jin, Yexiong Li, Jingbo Wang and Junlin Yi
    Citation: BMC Cancer 2023 23:724
    Content type: Study protocol Published on:

  39. It is widely accepted that chronic inflammatory bowel diseases significantly higher a risk for colorectal cancer development. Among different types of treatments for patients with colon cancer, novel protein-b...

    Authors: Mariam Al-Omari, Tareq Al-Omari, Nesreen Batainah, Khaled Al-Qauod, Beata Olejnicka and Sabina Janciauskiene
    Citation: BMC Cancer 2023 23:722
    Content type: Research Published on:

  40. SETD2-dependent H3 Lysine-36 trimethylation (H3K36me3) has been recently linked to the deposition of de-novo DNA methylation. SETD2 is frequently mutated in cancer, however, the functional impact of SETD2 loss an...

    Authors: Hira Javaid, Alessandro Barberis, Olga Chervova, Isar Nassiri, Vitaly Voloshin, Yusuke Sato, Seishi Ogawa, Benjamin Fairfax, Francesca Buffa and Timothy C. Humphrey
    Citation: BMC Cancer 2023 23:721
    Content type: Research Published on:

  41. The molecular subtypes of endometrial carcinoma are significantly correlated with survival outcomes and can guide surgical methods and postoperative adjuvant therapy. Among them, the TP53mut subtype has the wo...

    Authors: Wei Wang, Xiaoting Li, Yunong Gao, Hong Zheng and Min Gao
    Citation: BMC Cancer 2023 23:720
    Content type: Research Published on:

  42. To determine the role and rational application of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) adjuvant therapy in patients with completely resected stage IB-IIIA EGFR-mutant non-small...

    Authors: Shu-Ling Zhang, Xiao-Fang Yi, Le-Tian Huang, Li Sun, Jie-Tao Ma and Cheng-Bo Han
    Citation: BMC Cancer 2023 23:719
    Content type: Research Published on:

  44. The treatment of non-small cell lung cancer (NSCLC) is challenging due to immune tolerance and evasion. Salidroside (SAL) is an extract in traditional Chinese medicine and has a potential antitumor effect. How...

    Authors: Zexin Wen, Tong Liu, Yanli Zhang, Qiujuan Yue, Hang Meng, Yijie He, Yi Yang, Minghao Li, Jianwen Zheng and Wei Lin
    Citation: BMC Cancer 2023 23:717
    Content type: Research Published on:

  45. TUBA1C is an α-tubulin isoform involved in mitosis, and its dysregulation has been implicated in tumor progression. There is still no clear understanding of its role in bladder urothelial carcinoma (BLCA).

    Authors: Yi Jiang, Chao Zhu, Haoxuan Huang, Gaomin Huang, Bin Fu and Xiaoqing Xi
    Citation: BMC Cancer 2023 23:716
    Content type: Research Published on:

  46. Radical resection plus lymph node dissection is a common treatment for patients with T1-3N0M0 non-small cell lung cancer (NSCLC). Few models predicted the survival outcomes of these patients. This study aimed to ...

    Authors: Weijian Mei, Wang Yao, Zhengbo Song, Wenjie Jiao, Lianxin Zhu, Qinghua Huang, Chaolun An, Jianguang Shi, Guiping Yu, Pingli Sun, Yinbin Zhang, Jianfei Shen, Chunwei Xu, Han Yang, Qian Wang and Zhihua Zhu
    Citation: BMC Cancer 2023 23:715
    Content type: Research Published on:

  47. Precise prognostication is the key to optimum and effective treatment planning for early-stage hormone receptor (HR) positive, HER2/neu negative breast cancer patients. Differences in the breast cancer inciden...

    Authors: Purvish Parikh, Govind Babu, Randeep Singh, Vamshi Krishna, Amit Bhatt, Indu Bansal, Senthil Rajappa, Tarini Prasad Sahoo, Shyam Aggarwal, Ajay Bapna, Ghanshyam Biswas, SP Somashekhar, Jyoti Bajpai, Vashishtha Maniar, Sharad Desai, T Raja…
    Citation: BMC Cancer 2023 23:714
    Content type: Research Published on:

  48. Glioblastoma (GBM), a malignant brain tumor, has poor survival outcomes due to recurrence or drug resistance. We found that SH3GLB1 is a crucial factor for cells to evade temozolomide (TMZ) cytotoxicity throug...

    Authors: Chia-Hung Chien, Chien-Cheng Lai, Jian-Ying Chuang, Jui-Mei Chu, Chan-Chuan Liu and Kwang-Yu Chang
    Citation: BMC Cancer 2023 23:713
    Content type: Research Published on:

  49. Endometrial Cancer (EC) is one of the most prevalent malignancies that affect the female population globally. In the context of immunotherapy, Tumor Mutation Burden (TMB) in the DNA polymerase epsilon (POLE) s...

    Authors: Qing Tan, Qian Wang, Suoqin Jin, Fuling Zhou and Xiufen Zou
    Citation: BMC Cancer 2023 23:712
    Content type: Research Published on:

  50. Nanoliposomal irinotecan (nal-IRI) plus 5-fluorouracil (5-FU)/levo-leucovorin (Levo-LV) was approved for unresectable pancreatic cancer (UR-PC) in March 2020 in Japan. Levo-LV is administered by intravenous infus...

    Authors: Ryoji Takada, Kenji Ikezawa, Takuo Yamai, Ko Watsuji, Yusuke Seiki, Yasuharu Kawamoto, Takeru Hirao, Sena Higashi, Makiko Urabe, Yugo Kai, Tasuku Nakabori, Hiroyuki Uehara, Michiyo Kotani, Toshinari Yagi, Miho Kimura, Keisuke Nozaki…
    Citation: BMC Cancer 2023 23:711
    Content type: Research Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Follow

BMC Cancer

ISSN: 1471-2407

Contact us