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  1. Stonin1 (STON1) is an endocytic protein but its role in cancer remains unclear. Here, we investigated the immune role of STON1 in kidney renal clear cell carcinoma (KIRC).

    Authors: Axiu Zheng, Jianrong Bai, Yanping Ha, Yaping Yu, Yonghao Fan, Meihua Liang, Yanda Lu, Zhihua Shen, Botao Luo and Wei Jie
    Citation: BMC Cancer 2023 23:135
    Content type: Research Published on:

  2. Breast tumors show heterogeneity containing cancer stem cells as a small subpopulation of a tumor mass. CD44 as a cancer stem cells antigen is abnormally expressed by carcinomas of epithelial origin. Also, ove...

    Authors: Elaheh Gheybi, Ahmad Asoodeh and Jafar Amani
    Citation: BMC Cancer 2023 23:134
    Content type: Research Published on:

  3. Transporter associated with antigen processing 1 (TAP1) is a molecule involved in processing and presentation of major histocompatibility complex class I restricted antigens, including tumor-associated antigen...

    Authors: Zewei Tu, Kuangxun Li, Qiankun Ji, Yuyang Huang, Shigang Lv, Jingying Li, Lei Wu, Kai Huang and Xingen Zhu
    Citation: BMC Cancer 2023 23:133
    Content type: Research Published on:

  4. The ProtonCare Study Group (PCSG) was formed with the purpose to develop and implement a framework for evaluation of proton beam therapy (PBT) and the related care at a novel clinic (Skandionkliniken), based o...

    Authors: K Sjövall, U Langegård, P Fransson, E Nevo-Ohlsson, I Kristensen, K Ahlberg and B Johansson
    Citation: BMC Cancer 2023 23:132
    Content type: Research Published on:

  5. To explore the correlation of tumor necrosis factor-α-induced protein 8-like protein 3 (TIPE3) expressions in colorectal cancer (CRC) with tumor-immune infiltration and patient prognosis.

    Authors: Yue Xu, Yong Zhu, Hengbo Xia, Yanan Wang, Lin Li, Hong Wan, Shuping Zhang, Aman Xu, Liecheng Wang, Jiao Gong and Pingping Zhang
    Citation: BMC Cancer 2023 23:131
    Content type: Research Published on:

  6. Radiotherapy is an important treatment for lung cancer, mainly by triggering DNA double-strand breaks to induce cell death. Blocking DNA damage repair can increase the radiosensitivity of tumor cells. Recent s...

    Authors: Zhipeng Du, Fangxiao Zhang, Lei Liu, Hui Shen, Tingting Liu, Jing Jin, Nanxi Yu, Zhijie Wan, Hang Wang, Xuguang Hu, Yuanyuan Chen and Jianming Cai
    Citation: BMC Cancer 2023 23:130
    Content type: Research Published on:

  7. The tumor microenvironment (TME) in breast cancer plays a vital role in occurrence, development, and therapeutic responses. However, immune and stroma constituents in the TME are major obstacles to understandi...

    Authors: Xiao Chen, Jianzhong Zhang, Xinhan Lei, Lei Yang, Wanwan Li, Lu Zheng, Shuai Zhang, Yihan Ding, Jianing Shi, Lei Zhang, Jia Li, Tong Tang and WenJun Jia
    Citation: BMC Cancer 2023 23:129
    Content type: Research Published on:

  8. Few highly accurate tests can diagnose central lymph node metastasis (CLNM) of papillary thyroid cancer (PTC). Genetic sequencing of tumor tissue has allowed the targeting of certain genetic variants for perso...

    Authors: Zhongzhi Wang, Limeng Qu, Qitong Chen, Yong Zhou, Hongtao Duan, Baifeng Li, Yao Weng, Juan Su and Wenjun Yi
    Citation: BMC Cancer 2023 23:128
    Content type: Research Published on:

  9. Metastasis of cancer causes more than 90% of cancer deaths and is severely damaging to human health. In recent years, several studies have linked sarcopenia to shorter survival in patients with metastatic canc...

    Authors: Lingli Luo, Xiangru Shen, Shuai Fang, Teng Wan, Pan Liu, Peiling Li, Haifeng Tan, Yong Fu, Weiming Guo and Xiaojun Tang
    Citation: BMC Cancer 2023 23:127
    Content type: Research Published on:

  10. The prognostic significance of the relapse interval in patients with resected oral cavity squamous cell carcinoma (OCSCC) is a matter of ongoing debate. In this large-scale, registry-based, nationwide study, w...

    Authors: Chi-Ying Tsai, Yu-Wen Wen, Shu-Ru Lee, Shu-Hang Ng, Chung-Jan Kang, Li-Yu Lee, Chuen Hsueh, Chien-Yu Lin, Kang-Hsing Fan, Hung-Ming Wang, Chia-Hsun Hsieh, Chih-Hua Yeh, Chih-Hung Lin, Chung-Kan Tsao, Tuan-Jen Fang, Shiang-Fu Huang…
    Citation: BMC Cancer 2023 23:126
    Content type: Research Published on:

  11. Gliomas are the most frequent type of central nervous system tumor, accounting for more than 70% of all malignant CNS tumors. Recent research suggests that the hyaluronan-mediated motility receptor (HMMR) coul...

    Authors: Huaxin Zhu, Jiacong Tan, Xinyi Pan, Hengyang Ouyang, Zhixiong Zhang, Meihua Li and Yeyu Zhao
    Citation: BMC Cancer 2023 23:125
    Content type: Research Published on:

  13. B cell maturation antigen (BCMA) targeted immunotherapies have demonstrated remarkable clinical efficacy in multiple myeloma (MM). Here, we evaluated the BCMA expression in MM and other plasma cell dyscrasias ...

    Authors: Yanjie Xu, Xia Mao, Yimei Que, Menglei Xu, Chunhui Li, Varlene Daniela Fernandes Almeida, Di Wang and Chunrui Li
    Citation: BMC Cancer 2023 23:123
    Content type: Research Published on:

  14. Precursor B-cell acute lymphoblastic leukemia (pre-B ALL) is the most common hematological malignancy in children. Cellular metabolic reorganization is closely related to the progression and treatment of leuke...

    Authors: Huasu Zhu, Huixian Ma, Na Dong, Min Wu, Dong Li, Linghong Liu, Qing Shi and Xiuli Ju
    Citation: BMC Cancer 2023 23:122
    Content type: Research Published on:

  15. Pucotenlimab is a novel recombinant humanized anti-PD-1 (Programmed death-1) monoclonal antibody, which belongs to the human IgG4/kappa subtype, and can selectively block the binding of PD-1 with its ligands P...

    Authors: Chuanliang Cui, Yu Chen, Zhiguo Luo, Zhengyun Zou, Yu Jiang, Hongming Pan, Qingxia Fan, Jianfu Zhao, Qing Xu, Renbing Jiang, Xuan Wang, Taiyang Ma, Zhen Guo, Lu Si, Zhihong Chi, Xinan Sheng…
    Citation: BMC Cancer 2023 23:121
    Content type: Research Published on:

  16. Glioma is characterized by high morbidity, high mortality, and poor prognosis. Despite tremendous advances in the treatment of glioma, the prognosis of patients with glioma is still unsatisfactory. There is an...

    Authors: Xuqiang Zhu, Di Chen, Yiyu Sun, Shuo Yang, Weiguang Wang, Bing Liu, Peng Gao, Xueyuan Li, Lixin Wu, Siqi Ma, Wenyang Lin, Jiwei Ma and Dongming Yan
    Citation: BMC Cancer 2023 23:120
    Content type: Research Published on:

  17. To evaluate the diagnostic value of a multiparameter model based on 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) metabolic parameters and clinical variables in differentiating nonmetastatic g...

    Authors: Can Li, Xiaohui Luan, Xiao Bi, Shengxin Chen, Yue Pan, Jingfeng Zhang, Yun Han, Xiaodan Xu, Guanyun Wang and Baixuan Xu
    Citation: BMC Cancer 2023 23:119
    Content type: Research Published on:

  18. Conventional differential expression (DE) testing compares the grouped mean value of tumour samples to the grouped mean value of the normal samples, and may miss out dysregulated genes in small subgroup of pat...

    Authors: Ah-Jung Jeon, Yue-Yang Teo, Karthik Sekar, Shay Lee Chong, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Adaikalavan Ramasamy, Gokce Oguz, Alexander Yaw-Fui Chung, Chung Yip Chan…
    Citation: BMC Cancer 2023 23:118
    Content type: Research Published on:

  19. Recurrence due to the development of radioresistance remains a major challenge in the clinical management of nasopharyngeal carcinoma. The objective of this study was to increase the sensitivity of nasopharyng...

    Authors: Alvan Amos, Ning Jiang, Dan Zong, Jiajia Gu, Jiawei Zhou, Li Yin, Xia He, Yong Xu and Lirong Wu
    Citation: BMC Cancer 2023 23:117
    Content type: Research Published on:

  21. Childhood cancer survivors (CCS) are at increased risk of cardiomyopathy during pregnancy if they have prior cardiotoxic exposure. Currently, there is no consensus on the necessity, timing and modality of card...

    Authors: Julius C. Heemelaar, Steffie Heemelaar, Svenja N. Hertel, J. Wouter Jukema, Marieke Sueters, Marloes Louwerens and M. Louisa Antoni
    Citation: BMC Cancer 2023 23:115
    Content type: Research Published on:

  22. In low-resource settings with weak health systems, the WHO recommends clinical breast examination (CBE) as the most cost-effective breast screening modality for women. Evidence shows that biennial CBE leads to...

    Authors: Agani Afaya, Timothy Tienbia Laari, Abdul Aziz Seidu, Richard Adongo Afaya, Silas Selorm Daniels-Donkor, Vida Nyagre Yakong and Bright Opoku Ahinkorah
    Citation: BMC Cancer 2023 23:114
    Content type: Research Published on:

  23. Immune checkpoint inhibitor (ICI) therapy has become a viable treatment strategy in bladder cancer. However, treatment responses vary, and improved biomarkers are needed. Crucially, the characteristics of immu...

    Authors: Max Jung, Michael Rose, Ruth Knuechel, Chiara Loeffler, Hannah Muti, Jakob Nikolas Kather and Nadine T. Gaisa
    Citation: BMC Cancer 2023 23:113
    Content type: Research Published on:

  24. The TROIKA trial established that HD201 and trastuzumab were equivalent in terms of primary endpoints (total pathological complete response) following neoadjuvant treatment. The objective of the present analys...

    Authors: Xavier Pivot, Alexey Georgievitch Manikhas, Volodymyr Shamrai, Giorgi Dzagnidze, Hwoei Fen Soo Hoo, Viriya Kaewkangsadan, Fausto Petrelli, Cristian Villanueva, Jamie Kim, Sumita Pradhan, Litha Jaison, Peggy Feyaerts, Leonard Kaufman, Marie-Paule Derde, Filip Deforce and David G. Cox
    Citation: BMC Cancer 2023 23:112
    Content type: Research Published on:

  26. Early diagnosis of lung adenocarcinoma (LUAD), one of the most common types of lung cancer, is very important to improve the prognosis of patients. The current methods can’t meet the requirements of early diag...

    Authors: Junfeng Li, Jianjie Li, Huifeng Hao, Fangliang Lu, Jia Wang, Menglei Ma, Bo Jia, Minglei Zhuo, Jingjing Wang, Yujia Chi, Xiaoyu Zhai, Yuyan Wang, Meina Wu, Tongtong An, Jun Zhao, Fan Yang…
    Citation: BMC Cancer 2023 23:110
    Content type: Research Published on:

  27. Transcatheter arterial embolization (TAE) has long been used for hemostasis of traumatic or postoperative hemorrhage and embolization of tumors. Previous retrospective studies of TAE for painful bone metastase...

    Authors: Sadamoto Zenda, Yasunori Arai, Shunsuke Sugawara, Yoshitaka Inaba, Kazuki Hashimoto, Kouji Yamamoto, Yusuke Saigusa, Takashi Kawaguchi, Sanae Shimada, Marie Yokoyama, Tempei Miyaji, Tomoka Okano, Naoki Nakamura, Eisuke Kobayashi, Tatsuya Takagi, Yoshihisa Matsumoto…
    Citation: BMC Cancer 2023 23:109
    Content type: Study protocol Published on:

  28. As the dominant component of the tumor microenvironment, cancer-associated fibroblasts (CAFs), play a vital role in tumor progression. An increasing number of studies have confirmed that CAFs are involved in a...

    Authors: Zhiyang Zhou, Sixuan Guo, Shuhui Lai, Tao Wang, Yao Du, Junping Deng, Shun Zhang, Ge Gao and Jiangnan Zhang
    Citation: BMC Cancer 2023 23:108
    Content type: Research Published on:

  30. A more effective immune response against glioblastoma is needed in order to achieve better tumor control. Radiotherapy can induce anti-tumor mediated immune reactions, in addition to its dose response effects....

    Authors: Emma Liljedahl, Elise Konradsson, Emma Gustafsson, Karolina Förnvik Jonsson, Jill K. Olofsson, Kurt Osther, Crister Ceberg and Henrietta Nittby Redebrandt
    Citation: BMC Cancer 2023 23:106
    Content type: Research Published on:

  31. Cuproptosis, an emerging form of programmed cell death, has recently been identified. However, the association between cuproptosis-related long non-coding RNA (lncRNA) signature and the prognosis in prostate c...

    Authors: Xiaofeng Cheng, Zhenhao Zeng, Heng Yang, Yujun Chen, Yifu Liu, Xiaochen Zhou, Cheng Zhang and Gongxian Wang
    Citation: BMC Cancer 2023 23:105
    Content type: Research Published on:

  32. To explore the potential pathogenesis and clinical features of second primary glioblastoma (spGBM) following first primary renal cell carcinoma (fpRCC).

    Authors: Guang-Tao Zhang, Qi Liu, Fu-Xing Zuo, Hou-Jie Liu, Song-Quan Wang, Qing Yuan, Ang-Si Liu, Ke Hu, Xiao-Li Meng, Wei-Jia Wang, Hai-Peng Qian, Jing-Hai Wan and Hong-Qing Cai
    Citation: BMC Cancer 2023 23:104
    Content type: Research Published on:

  33. Real-world data of Palbociclib are insufficient in China. This study aimed to investigate the treatment pattern and real-world outcomes in hormone receptor positive and human epidermal growth factor 2 receptor...

    Authors: Jiao Yang, Bing Zhao, Xiaoling Ling, Donghui Li, Jiuda Zhao, Yonggang Lv, Guangxi Wang, Xinlan Liu, Nanlin Li and Jin Yang
    Citation: BMC Cancer 2023 23:103
    Content type: Research Published on:

  34. CD276 (also known as B7-H3) is one of the most important immune checkpoints of the CD28 and B7 superfamily, and its abnormal expression is closely associated with various types of cancer. It has been shown that C...

    Authors: Lirui Dai, Xuyang Guo, Zhe Xing, Yiran Tao, Wulong Liang, Zimin Shi, Weihua Hu, Shaolong Zhou and Xinjun Wang
    Citation: BMC Cancer 2023 23:102
    Content type: Research Published on:

  35. Systemic inflammation is crucial for the development and progression of cancers. The advanced lung cancer inflammation index (ALI) is considered to be a better indicator of systemic inflammation than current b...

    Authors: Lilong Zhang, Kailiang Zhao, Tianrui kuang, Kunpeng Wang, Dongqi Chai, Zhendong Qiu, Rongqiang Liu, Wenhong Deng and Weixing Wang
    Citation: BMC Cancer 2023 23:101
    Content type: Research Published on:

  36. The aim of this paper was to clarify the optimal minimum number of lymph node for CEA-elevated (≥ 5 ng/ml) colon cancer patients.

    Authors: Hao Zhang, Chunlin Wang, Yunxiao Liu, Hanqing Hu, Qingchao Tang, Rui Huang, Meng Wang and Guiyu Wang
    Citation: BMC Cancer 2023 23:100
    Content type: Research Published on:

  37. Both Red Blood Cell (RBC) transfusion and anemia are thought to negatively impact cancer survival. These effects have been reported with mixed findings in cancer of the esophagus. The potential impact of the a...

    Authors: Joseph P. Connor, Eric Destrampe, Daniel Robbins, Aaron S. Hess, Daniel McCarthy and James Maloney
    Citation: BMC Cancer 2023 23:99
    Content type: Research Published on:

  38. To compare the effectiveness of high-resolution dermal ultrasound (US) guided superficial radiotherapy (SRT) to non-image-guided radiotherapy in the treatment of early-stage Non-Melanoma Skin Cancer (NMSC).

    Authors: Lio Yu, Mairead Moloney, Songzhu Zheng and James Rogers
    Citation: BMC Cancer 2023 23:98
    Content type: Research Published on:

  39. Distant metastasis remains the main cause of death in breast cancer. Breast cancer risk is strongly influenced by pathogenic mutation.This study was designed to develop a multiple-feature model using clinicopa...

    Authors: Zhenzhen Shao, Jinpu Yu, Yanan Cheng, Wenjuan Ma, Peifang Liu and Hong Lu
    Citation: BMC Cancer 2023 23:97
    Content type: Research Published on:

  40. High expression of SETD1A, a histone methyltransferase that specifically methylates H3K4, acted as a key oncogene in several human cancers. However, the function and underlying molecular mechanism of SETD1A in...

    Authors: Hongjuan Chai, Chunpeng Pan, Mingyang Zhang, Haizhong Huo, Haiyan Shan and Jugang Wu
    Citation: BMC Cancer 2023 23:96
    Content type: Research Published on:

  41. To evaluate the overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) for primary cervical lymphoma (PCL), an extremely rare disease without treatment consensus.

    Authors: Lingyun Gao, Xiaoran Chen, Jing Zhao, Anli Xu, Meijuan Liu, Hongna Yu, Shujun Kong and Sijian Li
    Citation: BMC Cancer 2023 23:95
    Content type: Research Published on:

  42. PRECONNECT was an international, phase IIIb trial evaluating the safety and efficacy of trifluridine/tipiracil (FTD/TPI) for metastatic colorectal cancer (mCRC).

    Authors: Julien Taieb, Timothy Price, Loïck Vidot, Bénédicte Chevallier, Lucjan Wyrwicz and Jean-Baptiste Bachet
    Citation: BMC Cancer 2023 23:94
    Content type: Research Published on:

  43. This retrospective study explored the relationship between hormone receptor (HR), human epidermal growth factor receptor 2 (HER2) status, and bone involvement in the first distant metastases (DM) of Chinese br...

    Authors: Zhifeng Jia, Muwei Dai, Yuguang Shang, Yue Li and Zhensheng Li
    Citation: BMC Cancer 2023 23:93
    Content type: Research Published on:

  44. Understanding the latest global spatio-temporal pattern of prostate cancer burden attributable to smoking can help guide effective global health policy. This study aims to elucidate the trends in smoking-relat...

    Authors: Hanfei Zhang, Dingping Huang, Yingfeng Zhang, Xia Wang, Jiangtao Wu and Daqing Hong
    Citation: BMC Cancer 2023 23:92
    Content type: Research Published on:

  47. Ovarian cancer is a leading cause of female mortality. Epigenetic changes occur in early stages of carcinogenesis and represent a marker for cancer diagnosis. Protocadherin 17 (PCDH17) is a tumor suppressor gene ...

    Authors: Sherif Mohamed Elsharkawi, Dalal Elkaffash, Pacint Moez, Nour El-Etreby, Eman Sheta and Raghda Saad Zaghloul Taleb
    Citation: BMC Cancer 2023 23:89
    Content type: Research Published on:

  48. Magnetic resonance imaging (MRI) performs well in the locoregional assessment of extranodal nasal-type NK/T-cell lymphoma (ENKTCL). It’s important to assess the value of multi-modal MRI-based radiomics for est...

    Authors: Yu-Ting Zhao, Si-Ye Chen, Xin Liu, Yong Yang, Bo Chen, Yong-Wen Song, Hui Fang, Jing Jin, Yue-Ping Liu, Hao Jing, Yuan Tang, Ning Li, Ning-Ning Lu, Shu-Lian Wang, Han Ouyang, Chen Hu…
    Citation: BMC Cancer 2023 23:88
    Content type: Research Published on:

  49. Tumor micronecrosis is a histopathological feature predicting poor prognosis in patients with hepatocellular carcinoma (HCC) who underwent liver resection. However, the role of tumor micronecrosis in liver tra...

    Authors: Yangyang Wang, Wei Zhang, Hongbin Ge, Xu Han, Jiangchao Wu, Xuqi Sun, Ke Sun, Wanyue Cao, Chao Huang, Jingsong Li, Qi Zhang and Tingbo Liang
    Citation: BMC Cancer 2023 23:86
    Content type: Research Published on:

  50. Breast cancer patients of American Society of Clinical Oncology and the College of American Pathologists (ASCO/CAP) Group 2 were all HER2-negative according to the 2018 guideline, not HER2-positive as defined ...

    Authors: Shuling Zhou, Hong Lv, Anqi Li, Ming Li, Siyuan Zhong, Hongfen Lu, Xiaoyan Zhou, Qianming Bai and Wentao Yang
    Citation: BMC Cancer 2023 23:84
    Content type: Research Published on:

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