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  1. Double reading (DR) in screening mammography increases cancer detection and lowers recall rates, but has sustainability challenges due to workforce shortages. Artificial intelligence (AI) as an independent rea...

    Authors: Nisha Sharma, Annie Y. Ng, Jonathan J. James, Galvin Khara, Éva Ambrózay, Christopher C. Austin, Gábor Forrai, Georgia Fox, Ben Glocker, Andreas Heindl, Edit Karpati, Tobias M. Rijken, Vignesh Venkataraman, Joseph E. Yearsley and Peter D. Kecskemethy
    Citation: BMC Cancer 2023 23:460
  2. Triple negative BCa (TNBC) is defined by a lack of expression of estrogen (ERα), progesterone (PgR) receptors and human epidermal growth factor receptor 2 (HER2) as assessed by protein expression and/or gene a...

    Authors: Elena A. Takano, Melissa M. Younes, Katie Meehan, Lisa Spalding, Max Yan, Prue Allan, Stephen B. Fox, Andy Redfern, David Clouston, Graham G. Giles, Elizabeth L. Christie, Robin L. Anderson, Magnus Zethoven, Kelly-Anne Phillips, Kylie Gorringe and Kara L. Britt
    Citation: BMC Cancer 2023 23:459
  3. Pembrolizumab has become an integral first line therapeutic agent for non-small cell lung cancer (NSCLC), but its potential predictive role in clinical and molecular characteristics remains to be clarified. Ac...

    Authors: Wenjie Liu, Gengwei Huo and Peng Chen
    Citation: BMC Cancer 2023 23:458
  4. Smoking, alcohol consumption, and human papillomavirus (HPV) infection are known risk factors for oral squamous cell carcinoma (OSCC) including SCC of oropharynx (SCCOP) and SCC of oral cavity (SCCOC). Researc...

    Authors: Zheng Yang, Peng Sun, Kristina R. Dahlstrom, Neil Gross and Guojun Li
    Citation: BMC Cancer 2023 23:457
  5. To evaluate the feasibility and quality of biliary-enteric reconstruction (BER) in laparoscopic radical resection of hilar cholangiocarcinoma (LsRRH) versus open surgery and propose technical recommendations.

    Authors: Wenzheng Liu, Fei Xiong, Guanhua Wu, Qi Wang, Bing Wang and Yongjun Chen
    Citation: BMC Cancer 2023 23:456
  6. PVT1, a previously uncharacterized lncRNA, was identified as a critical regulator involved in multiple functions in tumor, including cell proliferation, cell motility, angiogenesis and so on. However, the clin...

    Authors: Yusheng Chen, Fengjin Ma, Zhe Zhang, Yang Guo, Hanwei Shen and Hang Chen
    Citation: BMC Cancer 2023 23:455
  7. Histone lysine demethylases (KDMs) have been reported in various malignances, which affect transcriptional regulation of tumor suppressor or oncogenes. However, the relationship between KDMs and formation of tumo...

    Authors: Haichao Zhang, Haoran Wang, Li Ye, Suyun Bao, Ruijia Zhang, Ji Che, Wenqin Luo, Cheng Yu and Wei Wang
    Citation: BMC Cancer 2023 23:454
  8. The cancer burden is a global public health concern associated with high morbidities and mortalities. Low and middle-income countries are more affected including South Africa. Limited access to oncology servic...

    Authors: Lumkile Wilmot Jojo and Nonyaniso Trustina Nkutu
    Citation: BMC Cancer 2023 23:453
  9. Tumour perineural invasion (PNI) is a predictor of poor prognosis, but its effect on the prognosis of patients with colorectal cancer (CRC) has not yet been elucidated.

    Authors: Le Qin, Yixin Heng, Shenghe Deng, Junnan Gu, Fuwei Mao, Yifan Xue, Zhenxing Jiang, Jun Wang, Denglong Cheng, Ke Wu, Yinghao Cao and Kailin Cai
    Citation: BMC Cancer 2023 23:452
  10. Selenium metabolism has been implicated in human health. This study aimed to identify a selenium metabolism regulator-based prognostic signature for hepatocellular carcinoma (HCC) and validate the role of INMT...

    Authors: Huishan Sun, Junyu Long, Bangyou Zuo, Yiran Li, Yu Song, Minghang Yu, Ziyu Xun, Yanyu Wang, Xi Wang, Xinting Sang and Haitao Zhao
    Citation: BMC Cancer 2023 23:451
  11. Total neoadjuvant therapy (TNT) is a novel treatment strategy that is an alternative to preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). However, an optimal protocol for TNT has ...

    Authors: Shinya Abe, Kazushige Kawai, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Hiroyuki Matsuzaki, Yuzo Nagai, Yuichiro Yoshioka, Takahide Shinagawa, Hirofumi Sonoda, Yoko Yamamoto, Koji Oba and Soichiro Ishihara
    Citation: BMC Cancer 2023 23:450
  12. Up to 70% of breast cancer patients report symptoms of insomnia during and after treatment. Despite the ubiquity of insomnia symptoms, they are under-screened, under-diagnosed and poorly managed in breast canc...

    Authors: Chloé Drozd, Elsa Curtit, Quentin Jacquinot, Charlène Marquine, Laura Mansi, Loïc Chaigneau, Erion Dobi, Julien Viot, Guillaume Meynard, Marie-Justine Paillard, Morgan Goujon, Pauline Roux, Dewi Vernerey, Valérie Gillet, Hubert Bourdin, Silvio Galli…
    Citation: BMC Cancer 2023 23:449
  13. Suboptimal treatment upon progression may affect overall survival (OS) results in oncology randomized controlled trials (RCTs). We aim to assess the proportion of trials reporting post-progression treatment.

    Authors: Timothée Olivier, Alyson Haslam and Vinay Prasad
    Citation: BMC Cancer 2023 23:448
  14. Leukemic cell metabolism plays significant roles in their proliferation and survival. These metabolic adaptations are under regulation by different factors. Programmed Death Ligand -1 (CD-274) is one of the im...

    Authors: Mojdeh Soltani, Mustafa Ghanadian, Behrooz Ghezelbash, Abolfazl Shokouhi, Andrey A. Zamyatnin Jr, Alexandr V. Bazhin and Mazdak Ganjalikhani-Hakemi
    Citation: BMC Cancer 2023 23:447
  15. Upfront high-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) remains a profitable strategy for newly diagnosed multiple myeloma (MM) patients in the context of novel agents. However,...

    Authors: Chi-Maw Lin, Lih-Chyun Chang, Wen-Yi Shau, Chi-Ling Chen, Chi-Yuan Yao and Feng-Ming Tien
    Citation: BMC Cancer 2023 23:446
  16. Cholangiocarcinoma (CHOL) is the second most common primary hepatic malignant tumor, following hepatocellular carcinoma (HCC). CHOL is highly aggressive and heterogeneous resulting in poor prognosis. The diagn...

    Authors: Shuochen Liu, Shilong Fan, Yirui Wang, Ruixiang Chen, Ziyi Wang, Yaodong Zhang, Wangjie Jiang, Yananlan Chen, Xiao Xu, Yue Yu, Changxian Li and Xiangcheng Li
    Citation: BMC Cancer 2023 23:444
  17. Immune checkpoint inhibitors (ICI)-based combination strategies have improved the survival outcomes in advanced non-small cell lung cancers; however, data regarding their efficacy remains limited for uncommon ...

    Authors: Lianxi Song, Fei Zhou, Tian Xu, Liang Zeng, Qing Xia, Zhan Wang, Li Deng, Yizhi Li, Haoyue Qin, Huan Yan, Zhe Huang, Jinye Mi, Qinqin Xu, Nong Yang, Caicun Zhou and Yongchang Zhang
    Citation: BMC Cancer 2023 23:443
  18. Many studies have explored the cost-effectiveness of immunotherapy versus chemotherapy alone. However, there is paucity of evidence on direct pharmacoeconomic studies related to immunotherapy combinations. Thu...

    Authors: Wen Hui, Ruomeng Song, Hongyu Tao, Zhixiang Gao, Min Zhu, Mingyue Zhang, Huazhang Wu, Daichen Gong, Xiyan Zhang and Yuanyi Cai
    Citation: BMC Cancer 2023 23:442
  19. The CDH1 gene codes for the epithelial-cadherin (E-cad) protein, which is embedded in the plasma membrane of epithelial cells to form adherens junctions. E-cad is known to be essential for maintaining the integri...

    Authors: Brihget Sicairos, Shorna Alam and Yuchun Du
    Citation: BMC Cancer 2023 23:441
  20. COVID-19 has impacted both society and medical care. While Germany entered the first lockdown in spring 2020, the PIKKO study (Patient information, communication and competence empowerment in oncology) was sti...

    Authors: Nico Schneider, Bernhard Strauss, Jutta Hübner, Christian Keinki, Florian Brandt, Sabine Rubai and Uwe Altmann
    Citation: BMC Cancer 2023 23:439
  21. Breast cancer is highly heterogeneous, suggesting that small but relevant subsets have been under-recognized. Rare and mainly triple-negative breast cancers (TNBCs) were recently found to exhibit tuft cell-lik...

    Authors: Yosuke Yamada, Ronald Simon, Kosuke Iwane, Yuki Nakanishi, Yasuhide Takeuchi, Akihiko Yoshizawa, Masahiro Takada, Masakazu Toi, Hironori Haga, Alexander Marx and Guido Sauter
    Citation: BMC Cancer 2023 23:438
  22. The most common subtype of ovarian cancer (OC) showing immunogenic potential is represented by the high-grade serous ovarian cancer (HGSOC), which is characterized by the presence of tumor-infiltrating immune ...

    Authors: Daniele Fanale, Chiara Brando, Lidia Rita Corsini, Sofia Cutaia, Mariano Catello Di Donna, Ugo Randazzo, Clarissa Filorizzo, Chiara Lisanti, Luigi Magrin, Vittorio Gurrera, Raffaella Romano, Alessandra Dimino, Tancredi Didier Bazan Russo, Daniel Olive, Salvatore Vieni, Gianni Pantuso…
    Citation: BMC Cancer 2023 23:437
  23. Liver metastasis is a poor prognostic factor for treatment of advanced cutaneous melanoma with either immunotherapy or targeted therapies. In this study we focused on NRAS mutated melanoma, a cohort with high unm...

    Authors: Bianca Dietsch, Céline Weller, Carsten Sticht, Carolina de la Torre, Martin Kramer, Sergij Goerdt, Cyrill Géraud and Sebastian A. Wohlfeil
    Citation: BMC Cancer 2023 23:436
  24. Gemcitabine (Gem) has been a standard first-line drug for pancreatic cancer (PCa) treatment; however, Gem's rapid metabolism and systemic instability (short half-life) limit its clinical outcome. The objective...

    Authors: Andriana Inkoom, Nkafu Bechem Ndemazie, Taylor Smith, Esther Frimpong, Raviteja Bulusu, Rosemary Poku, Xue Zhu, Bo Han, Jose Trevino and Edward Agyare
    Citation: BMC Cancer 2023 23:435
  25. Breast cancer is associated with alterations in lipid metabolism. The treatment of breast cancer can also affect serum lipid composition. The purpose of this study was the examination of serum fatty acids (FAs...

    Authors: Alicja Pakiet, Agata Jędrzejewska, Katarzyna Duzowska, Alina Wacławska, Patrycja Jabłońska, Jacek Zieliński, Adriana Mika, Tomasz Śledziński and Ewa Słomińska
    Citation: BMC Cancer 2023 23:433
  26. In recent years, an increasing number of studies have revealed that patients’ preoperative inflammatory response, coagulation function, and nutritional status are all linked to the occurrence, development, ang...

    Authors: Xiaozong Duan, Bo Yang, Chengbin Zhao, Boran Tie, Lei Cao and Yuyuan Gao
    Citation: BMC Cancer 2023 23:432
  27. Neoadjuvant chemotherapy (NAC) has become the standard therapeutic option for early high-risk and locally advanced breast cancer. However, response rates to NAC vary between patients, causing delays in treatme...

    Authors: Jieqiu Zhang, Qi Wu, Wei Yin, Lu Yang, Bo Xiao, Jianmei Wang and Xiaopeng Yao
    Citation: BMC Cancer 2023 23:431
  28. Pancreatic adenocarcinoma (PAAD) is a leading cause of malignancy-related deaths worldwide, and the efficacy of immunotherapy on PAAD is limited. Studies report that long non-coding RNAs (lncRNAs) play an impo...

    Authors: Yinjiang Zhang, Yao Wang, Xu He, Rongfei Yao, Lu Fan, Linyi Zhao, Binan Lu and Zongran Pang
    Citation: BMC Cancer 2023 23:430
  29. Cervical cancer (CC) rates are high in Uganda, yet CC screening rates are very low. Our peer advocacy group intervention, Game Changers for Cervical Cancer Prevention (GC-CCP), was shown to increase CC screeni...

    Authors: Joseph KB Matovu, Glenn J. Wagner, Margrethe Juncker, Eve Namisango, Kathryn Bouskill, Sylvia Nakami, Jolly Beyeza-Kashesya, Emmanuel Luyirika and Rhoda K. Wanyenze
    Citation: BMC Cancer 2023 23:428
  30. Though behavioral activation (BA) has been shown to be effective for depression, evidence in patients with advanced cancer has not been established. This study aimed to examine the effectiveness of a BA progra...

    Authors: Takatoshi Hirayama, Yuko Ogawa, Asao Ogawa, Emi Igarashi, Saaya Soejima, Kotone Hata, Yusuke Utsumi, Yuki Mashiko, Kyoka Ogata, Ayako Kayano, Yuko Yanai and Shin-ichi Suzuki
    Citation: BMC Cancer 2023 23:427
  31. In previous study, we found that the content of medium-chain fatty acid Caprylic Acid (FFA C8:0) may be an important risk factor of obesity induced prostate cancer (PCa). However, the relationship between FFA ...

    Authors: Xue Li, Chenggang Yuan, Bingqi Yang, Huai Pang, Wei Li, Menghuan Li, Yihan Tang, Dingling Ma, Jianxin Xie, Jingzhou Wang and Jun Zhang
    Citation: BMC Cancer 2023 23:426
  32. Previously studies shown a potential risk of antihypertensive medicines in relation to cancer susceptibility, which creating significant debate in the scientific community and public concern. We sought to inve...

    Authors: Suna Wang, Li Xie, Jianlin Zhuang, Ying Qian, Guanglu Zhang, Xiaowei Quan, Lei Li, Herbert Yu, Weituo Zhang, Wensui Zhao and Biyun Qian
    Citation: BMC Cancer 2023 23:425
  33. The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a cancer biomarker. Furthermore, fusion of the MALAT1 gene with glioma-associated oncogene 1 (GLI1) is a diagnostic marke...

    Authors: Taiji Hamada, Michiyo Higashi, Seiya Yokoyama, Toshiaki Akahane, Masanori Hisaoka, Hirotsugu Noguchi, Tatsuhiko Furukawa and Akihide Tanimoto
    Citation: BMC Cancer 2023 23:424
  34. Postoperative adjuvant chemotherapy (AC) is now well-accepted as standard for high-risk stage II and stage III colorectal cancer (CRC) patients, however the optimal time to initiate AC remains elusive.

    Authors: Yuchong Yang, Yao Lu, Hui Tan, Ming Bai, Xia Wang, Shaohua Ge, Tao Ning, Le Zhang, Jingjing Duan, Yansha Sun, Rui Liu, Hongli Li, Yi Ba and Ting Deng
    Citation: BMC Cancer 2023 23:422
  35. To compare the oncological outcomes of patients with FIGO 2018 stage IIIC cervical cancer (CC) involving different local tumor factors who underwent abdominal radical hysterectomy (ARH), neoadjuvant chemothera...

    Authors: Yanna Ye, Zhiqiang Li, Shan Kang, Yongxiu Yang, Bin Ling, Li Wang, Jilong Yao, Pengfei Li, Xueqin Wang, Shipeng Gong, Huijian Fan, Yanxiang Kong, Yuye Cao, Jinghe Lang, Ping Liu and Chunlin Chen
    Citation: BMC Cancer 2023 23:421
  36. Glioma is the most common and aggressive tumor in the adult brain. Recent studies have indicated that Zinc finger DHHC-type palmitoyltransferases (ZDHHCs) play vital roles in regulating the progression of glio...

    Authors: Zhen-Yuan Liu, Tian Lan, Feng Tang, Yong-Ze He, Jin-Sheng Liu, Jin-Zhou Yang, Xi Chen, Ze-Fen Wang and Zhi-Qiang Li
    Citation: BMC Cancer 2023 23:420
  37. Partial breast irradiation (PBI) is standard of care in low-risk breast cancer patients after breast-conserving surgery (BCS). Pre-operative PBI can result in tumor downstaging and more precise target definiti...

    Authors: Yasmin A. Civil, Arlene L. Oei, Katya M. Duvivier, Nina Bijker, Philip Meijnen, Lorraine Donkers, Sonja Verheijen, Zdenko van Kesteren, Miguel A. Palacios, Laura J. Schijf, Ellis Barbé, Inge R. H. M. Konings, C. Willemien Menke -van der Houven van Oordt, Paulien G. Westhoff, Hanneke J. M. Meijer, Gwen M. P. Diepenhorst…
    Citation: BMC Cancer 2023 23:419
  38. To evaluate the clinical efficacy of percutaneous biliary drainage (PBD) combined with 125I seed strand brachytherapy (ISSB) for the treatment of hilar cholangiocarcinoma (HCCA).

    Authors: Chengzhi Zhang, Mengyao Song, Zhanguo Sun, Yi Fang, Yiming Liu, Kaihao Xu, Xinwei Han and Dechao Jiao
    Citation: BMC Cancer 2023 23:418
  39. PTPRF interacting protein alpha 1 (PPFIA1) is reportedly related to the occurrence and progression of several kinds of malignancies. However, its role in esophageal squamous cell carcinoma (ESCC) is unclear. T...

    Authors: Yongyin Gao, Lizhao Guan, Ran Jia, Wanyi Xiao, Youming Han, Yue Li, Peng Tang, Zhentao Yu and Hongdian Zhang
    Citation: BMC Cancer 2023 23:417
  40. Pathologic complete response (pCR) following preoperative systemic therapy is associated with improved outcomes after subsequent liver transplant/resection in hepatocellular carcinoma (HCC). However, the relat...

    Authors: Cheng Huang, Xiao-Dong Zhu, Ying-Hao Shen, Bin Xu, Dong Wu, Yuan Ji, Ling-Li Chen, Tian-Qiang Song, Wei Zhang, Zhi-Ming Zeng, Hua-Sheng Huang, Kui Wang, Lan-Qing Huang, Yong-Jun Chen, Yu-Chen Yang, Le-Du Zhou…
    Citation: BMC Cancer 2023 23:416
  41. Ferroptosis is iron-dependent non-apoptotic cell death, that is characterized by the excessive accumulation of lipid peroxides. Ferroptosis-inducing therapy also shows promise in the treatment of cancers. Howe...

    Authors: Xinzhuang Wang, Hong Zhang, Mingchu Zhang, Xuezhi Zhang, Wenbin Mao and Ming Gao
    Citation: BMC Cancer 2023 23:415
  42. Recent reports suggested combining ramucirumab with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) to overcome EGFR resistance in non–small cell lung cancer (NSCLC). Nonetheless, evi...

    Authors: Chun-Yao Huang, Hui-Li Huang, Chou-Chin Lan, Yi-Chih Huang and Yao-Kuang Wu
    Citation: BMC Cancer 2023 23:413
  43. Papillary thyroid cancer (PTC) is the most frequent subtype of thyroid cancer, but 20% of cases are indeterminate (i.e., cannot be accurately diagnosed) based on preoperative cytology, which might lead to surg...

    Authors: Guochao Ye, Xiaomei Zhang, Mansheng Li, Zixiang Lin, Yongcan Xu, Haoru Dong, Jie Zhou, Jiaqi Zhang, Sheng Wang, Yunping Zhu, Xiaobo Yu and Xu Qian
    Citation: BMC Cancer 2023 23:412
  44. To increase the chances of finding efficacious anticancer drugs, improve development times and reduce costs, it is of interest to rank test compounds based on their potential for human use as early as possible...

    Authors: Marcus Baaz, Tim Cardilin, Floriane Lignet, Astrid Zimmermann, Samer El Bawab, Johan Gabrielsson and Mats Jirstrand
    Citation: BMC Cancer 2023 23:409

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