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  1. Pancreatic cancer is the foremost contributor to cancer-related deaths globally, and its prevalence continues to rise annually. Nevertheless, the underlying mechanisms behind its development remain unclear and...

    Authors: Feng Zhao, Anli Chen, Xiaotian Wu, Xiangyu Deng, Jiali Yang and Jianjiang Xue
    Citation: BMC Cancer 2024 24:478
    Content type: Research Published on:

  2. Limited evidence exists on the population attributable fraction (PAF) of cancer cases and deaths in Latin America. In Peru several studies have been published regarding the PAF of various risk factors and thei...

    Authors: Jhony A. De La Cruz-Vargas, Willy Ramos, Willer Chanduví, Lucy E. Correa-López, Nadia Guerrero, Joan Loayza-Castro, Irene Tami-Maury and Diego Venegas
    Citation: BMC Cancer 2024 24:477
    Content type: Research Published on:

  3. In recent years, there has been extensive research on the role of exercise as an adjunctive therapy for cancer. However, the potential mechanisms underlying the anti-tumor therapy of exercise in lung cancer re...

    Authors: Sai-Nan Miao, Meng-Qi Chai, Xiang-Yu Liu, Cheng-Yu Wei, Cun-Cun Zhang, Ning-Ning Sun, Qing-Ze Fei, Lin-Lin Peng and Huan Qiu
    Citation: BMC Cancer 2024 24:474
    Content type: Research Published on:

  4. Prostate cancer (PCa) is becoming the most common malignancy in men worldwide. We investigated the effect of astragaloside IV combined with PESV on the gut microbiota and metabolite of PCa mice and the process...

    Authors: Xujun You, Junfeng Qiu, Qixin Li, Qing Zhang, Wen Sheng, Yiguo Cao and Wei Fu
    Citation: BMC Cancer 2024 24:472
    Content type: Research Published on:

  5. Clear cell renal cell carcinoma (ccRCC) is associated with a high prevalence of cancer-related deaths. The survival rates of patients are significantly lower in late-stage ccRCC than in early-stage ccRCC, due ...

    Authors: Jun Wang, Xiaoming He, Yuanyuan Mi, Yong Q. Chen, Jie Li and Rong Wang
    Citation: BMC Cancer 2024 24:463
    Content type: Research Published on:

  6. Patients with metastatic gastric cancer (mGC) have poor prognosis. This real-world study aimed to describe treatment regimens and survival of mGC patients.

    Authors: Jaime Luna, Nils Picker, Thomas Wilke, Magnus Lutz, Jürgen Hess, Bernhard Mörtl, Yan Xiong and Thorsten Oliver Götze
    Citation: BMC Cancer 2024 24:462
    Content type: Research Published on:

  7. Despite numerous studies on racial/ethnic disparities among patients with breast cancer, there is a paucity of literature evaluating racial/ethnic differences in 21-gene recurrence score (RS) and survival diff...

    Authors: Jasmin Gill, Keerti Yendamuri, Udit Chatterjee, Song Yao, Oluwadamilola T. Oladeru, Anurag K. Singh and Sung Jun Ma
    Citation: BMC Cancer 2024 24:461
    Content type: Research Published on:

  8. To predict pathological complete response (pCR) in patients receiving neoadjuvant immunochemotherapy (nICT) for esophageal squamous cell carcinoma (ESCC), we explored the factors that influence pCR after nICT ...

    Authors: Yu Yang, Yan Yi, Zhongtang Wang, Shanshan Li, Bin Zhang, Zheng Sang, Lili Zhang, Qiang Cao and Baosheng Li
    Citation: BMC Cancer 2024 24:460
    Content type: Research Published on:

  9. Head and neck squamous cell carcinoma (HNSCC) represents a common and heterogeneous malignancy of the oral cavity, pharynx and larynx. Surgery and radio(chemo)therapy are the standard treatment options and als...

    Authors: Christian Idel, Jonas Fleckner, Kirstin Plötze-Martin, Lotte Werner, Dirk Rades, Marie-Nicole Theodoraki, Linda Hofmann, Diana Huber, Anke Leichtle, Thomas K. Hoffmann, Karl-Ludwig Bruchhage and Ralph Pries
    Citation: BMC Cancer 2024 24:459
    Content type: Research Published on:

  10. The identification of survival predictors is crucial for early intervention to improve outcome in acute myeloid leukemia (AML). This study aim to identify chest computed tomography (CT)-derived features to pre...

    Authors: Xiaoping Yi, Huien Zhan, Jun Lyu, Juan Du, Min Dai, Min Zhao, Yu Zhang, Cheng Zhou, Xin Xu, Yi Fan, Lin Li, Baoxia Dong, Xinya Jiang, Zeyu Xiao, Jihao Zhou, Minyi Zhao…
    Citation: BMC Cancer 2024 24:458
    Content type: Research Published on:

  11. The SARS-CoV-2 (COVID-19) pandemic has strained healthcare systems and presented unique challenges for children requiring cancer care, particularly in low- and middle-income countries. This study aimed to asse...

    Authors: Yotham Gwanika, Hannah E. Rice, Madeline Metcalf, Pamela Espinoza, Happiness D. Kajoka, Henry E. Rice, Catherine Staton, Blandina T. Mmbaga, Esther Majaliwa, Emily R. Smith and Cesia Cotache-Condor
    Citation: BMC Cancer 2024 24:457
    Content type: Research Published on:

  12. The incidence of early-onset colorectal cancer (EOCRC), diagnosed before age 50, has been rising in many countries in the past few decades. This study aims to evaluate this trend in Aotearoa New Zealand and as...

    Authors: Oliver Waddell, John Pearson, Andrew McCombie, Harriet Marshall, Rachel Purcell, Jacqueline Keenan, Tamara Glyn and Frank Frizelle
    Citation: BMC Cancer 2024 24:456
    Content type: Research Published on:

  15. Evidence from observational studies suggests an association between chronic obstructive pulmonary disease (COPD) and lung cancer. The potential interactions between the immune system and the lungs may play a c...

    Authors: Dengfeng Zhang, Haitao Liu, Fangchao Zhao, Pengfei Guo, Jing Li, Tianxing Lu, Zhirong Li and Shujun Li
    Citation: BMC Cancer 2024 24:453
    Content type: Research Published on:

  16. Establishment of sister chromatid cohesion N-acetyltransferase 2 (ESCO2) is involved in the mitotic S-phase adhesins acetylation and is responsible for bridging two sister chromatids. However, present ESCO2 ca...

    Authors: Yue Huang, Dapeng Chen, Yi Bai, Yamin Zhang, Zhiwen Zheng, Qingfeng Fu, Bocun Yi, Yuchen Jiang, Zhihong Zhang and Jianqiang Zhu
    Citation: BMC Cancer 2024 24:452
    Content type: Research Published on:

  17. Clear cell renal cell carcinoma (ccRCC) is the prevailing histological subtype of renal cell carcinoma and has unique metabolic reprogramming during its occurrence and development. Cell senescence is one of th...

    Authors: Lijie Zhou, Youmiao Zeng, Yuanhao Liu, Kaixuan Du, Yongbo Luo, Yiheng Dai, Wenbang Pan, Lailai Zhang, Lei Zhang, Fengyan Tian and Chaohui Gu
    Citation: BMC Cancer 2024 24:451
    Content type: Research Published on:

  18. Knowledge of risk factors and symptoms of cervical cancer has been found to promote uptake of screening of cervical cancer. Most interventions targeted women without much involvement of men (husbands/decision ...

    Authors: Carolyn Nakisige, Marlieke de Fouw, Miriam Nakalembe, Jackson Orem, Dan Atukonyera, Mwalimu Musheshe, Jaap Koot, Janine de Zeeuw, Jogchum Beltman and Jelle Stekelenburg
    Citation: BMC Cancer 2024 24:450
    Content type: Research Published on:

  19. While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to sur...

    Authors: Maximilian Y. Deng, Amanda Salviano da Silva, Pauline Carlotta Göller, Laila König, Henning Schäfer, Cecile Maire, Adriane Lentz-Hommertgen, Thomas Held, Sebastian Regnery, Tanja Eichkorn, Florian Stritzke, Lukas Bauer, Daniel Schnell, Klaus Herfarth, Andreas von Deimling, Sandro Krieg…
    Citation: BMC Cancer 2024 24:449
    Content type: Study Protocol Published on:

  21. High rates of negative intrusive thoughts have been reported among cancer patients. Prevalent users of beta-blocker therapy have reported lower levels of cancer related intrusive thoughts than non-user. The ai...

    Authors: Carolina Ehrencrona, Ying Li, Eva Angenete, Eva Haglind, Stefan Franzén, Anna Grimby-Ekman and David Bock
    Citation: BMC Cancer 2024 24:447
    Content type: Research Published on:

  22. In patients with previously treated RAS-mutated microsatellite-stable (MSS) metastatic colorectal cancer (mCRC), a multicenter open-label phase 1b/2 trial was conducted to define the safety and efficacy of the ME...

    Authors: Elena Elez, Antonio Cubillo, Pilar Garcia Alfonso, Mark R. Middleton, Ian Chau, Baha Alkuzweny, Ann Alcasid, Xiaosong Zhang and Eric Van Cutsem
    Citation: BMC Cancer 2024 24:446
    Content type: Research Published on:

  23. Proprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic regulator of low-density lipoprotein (LDL) by interacting with low-density lip...

    Authors: Hanbing Wang, Xin Zhang, Yipeng Zhang, Tao Shi, Yue Zhang, Xueru Song, Baorui Liu, Yue Wang and Jia Wei
    Citation: BMC Cancer 2024 24:445
    Content type: Research Published on:

  24. Transforming growth factor-β (TGF-β) is a cytokine with multiple functions, including cell growth regulation, extracellular matrix production, angiogenesis homeostasis adjustment and et al. TGF-β pathway activ...

    Authors: Ye Guo, Zishu Wang, Huan Zhou, Hongming Pan, Weidong Han, Yanhong Deng, Qun Li, Junli Xue, Xiaoxiao Ge, Shuang Wang, Jing Wang, Yue Zhang, Congqiao Zhao, Huaqiang Zhu, Yu Wang, Haige Shen…
    Citation: BMC Cancer 2024 24:444
    Content type: Research Published on:

  25. Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and ...

    Authors: E Routila, R Mahran, S Salminen, H Irjala, E Haapio, E Kytö, S Ventelä, K Petterson, J Routila, K Gidwani and J Leivo
    Citation: BMC Cancer 2024 24:443
    Content type: Research Published on:

  26. Head and neck cancers, particularly oropharyngeal cancers (OPC), have been increasingly associated with human papillomavirus (HPV) infections, specifically HPV16. The current methods for HPV16 detection primar...

    Authors: Fiona Deutsch, Dayna Sais, Ni Keatinge, Meredith Hill, Ngoc Ha Tran, Michael Elliott and Nham Tran
    Citation: BMC Cancer 2024 24:442
    Content type: Research Published on:

  27. We recently found that epiplakin 1 (EPPK1) alterations were present in 12% of lung adenocarcinoma (LUAD) cases and were associated with a poor prognosis in early-stage LUAD when combined with other molecular a...

    Authors: Ken Arimura, Michael Kammer, S. M. Jamshedur Rahman, Chen Sheau-Chiann, Shilin Zhao, Chen Heidi, Rosana Eisenberg, Yong Zou, Sanja Antic, Bradley Richmond, Etsuko Tagaya, Eric Grogan, Pierre Massion and Fabien Maldonado
    Citation: BMC Cancer 2024 24:441
    Content type: Research Published on:

  28. Triple-negative breast cancer (TNBC) is a life-threatening subtype of breast cancer with limited treatment options. Therefore, this network meta-analysis (NMA) aimed to evaluate and compare the effect of vario...

    Authors: Zhilin Liu, Jinming Li, Fuxing Zhao, Dengfeng Ren, Zitao Li, Yongzhi Chen, Shifen Huang, Zhen Liu, Yi Zhao, Miaozhou Wang, Huihui Li, ZhengBo Xu, Guoshuang Shen and Jiuda Zhao
    Citation: BMC Cancer 2024 24:440
    Content type: Research Published on:

  29. Renal cell carcinoma (RCC) is a prevalent and extensively immune-infiltrated malignancy of the urinary system. Immune cells play a crucial role in both the progression and therapeutic interventions targeting R...

    Authors: Zhongwen Lu, Yu Yin, Tian Rao, Xinchi Xu, Kai Zhao, Zhanpeng Liu, Chao Qin and Min Tang
    Citation: BMC Cancer 2024 24:439
    Content type: Research Published on:

  30. Based on the quantitative and qualitative features of CT imaging, a model for predicting the invasiveness of ground-glass nodules (GGNs) was constructed, which could provide a reference value for preoperative ...

    Authors: Yantao Yang, Jing Xu, Wei Wang, Mingsheng Ma, Qiubo Huang, Chen Zhou, Jie Zhao, Yaowu Duan, Jia Luo, Jiezhi Jiang and Lianhua Ye
    Citation: BMC Cancer 2024 24:438
    Content type: Research Published on:

  31. Soft tissue sarcomas (STS), have significant inter- and intra-tumoral heterogeneity, with poor response to standard neoadjuvant radiotherapy (RT). Achieving a favorable pathologic response (FPR ≥ 95%) from RT ...

    Authors: Arash O. Naghavi, J. M. Bryant, Youngchul Kim, Joseph Weygand, Gage Redler, Austin J. Sim, Justin Miller, Kaitlyn Coucoules, Lauren Taylor Michael, Warren E. Gloria, George Yang, Stephen A. Rosenberg, Kamran Ahmed, Marilyn M. Bui, Evita B. Henderson-Jackson, Andrew Lee…
    Citation: BMC Cancer 2024 24:437
    Content type: Study Protocol Published on:

  32. Biliary tract cancers (BTCs) are rare and lethal cancers, with a 5-year survival inferior to 20%(1–3). The only potential curative treatment is surgical resection. However, despite complex surgical procedures ...

    Authors: Monica Niger, Federico Nichetti, Lorenzo Fornaro, Chiara Pircher, Federica Morano, Federica Palermo, Lorenza Rimassa, Tiziana Pressiani, Rossana Berardi, Andrea Casadei Gardini, Elisa Sperti, Lisa Salvatore, Davide Melisi, Francesca Bergamo, Salvatore Siena, Stefania Mosconi…
    Citation: BMC Cancer 2024 24:436
    Content type: Study Protocol Published on:

  33. To establish and validate a predictive model combining pretreatment multiparametric MRI-based radiomic signatures and clinical characteristics for the risk evaluation of early rapid metastasis in nasopharyngea...

    Authors: Xiujuan Cao, Xiaowen Wang, Jian Song, Ya Su, Lizhen Wang and Yong Yin
    Citation: BMC Cancer 2024 24:435
    Content type: Research Published on:

  34. Lung adenocarcinoma, a leading cause of cancer-related mortality, demands precise prognostic indicators for effective management. The presence of spread through air space (STAS) indicates adverse tumor behavio...

    Authors: Haijun Li, Lifeng Li, Yumeng Liu, Yingke Deng, Yu Zhu, Ling Huang, Ting Long, Li Zeng, Yongqiang Shu and Dechang Peng
    Citation: BMC Cancer 2024 24:434
    Content type: Research Published on:

  35. Perineural invasion (PNI) is the invasion of nerves by cancer cells and is associated with poor survival in stage II colorectal cancer. However, PNI can be further subdivided according to the depth of invasion...

    Authors: Hao Chen, Chao Wang, Zexian Chen, Tianze Huang, Yanyun Lin, Junguo Chen, Bin Zhang and Xiaosheng He
    Citation: BMC Cancer 2024 24:433
    Content type: Research Published on:

  36. One-third of diffuse large B-cell lymphoma (DLBCL) patients suffer relapse after standard treatment. Eukaryotic initiation factor 3a (eIF3a) is a key player in the initial stage of translation, which has been ...

    Authors: Hongkun Sun, Juanjuan Shang, Xiao Liu, Shuai Ren, Shunfeng Hu and Xin Wang
    Citation: BMC Cancer 2024 24:432
    Content type: Research Published on:

  37. Dose-escalated radiotherapy is known to improve progression free survival in patients with localized prostate cancer, and recent advances have led to the standardization of ultrahypofractionated stereotactic a...

    Authors: Elisha Fredman, Oded Icht, Assaf Moore, Dimitri Bragilovski, Jonathan Kindler, Shay Golan and Dror Limon
    Citation: BMC Cancer 2024 24:431
    Content type: Study Protocol Published on:

  38. The KEYNOTE-048 trial showed that pembrolizumab-based first-line treatment for R/M HNSCC led to improved OS in the PD-L1 CPS ≥ 1 population when compared to the EXTREME regimen. However, the R/M HNSCC real-world ...

    Authors: Alessio Cirillo, Daniele Marinelli, Umberto Romeo, Daniela Messineo, Francesca De Felice, Marco De Vincentiis, Valentino Valentini, Silvia Mezi, Filippo Valentini, Luca Vivona, Antonella Chiavassa, Bruna Cerbelli, Daniele Santini, Paolo Bossi, Antonella Polimeni, Paolo Marchetti…
    Citation: BMC Cancer 2024 24:430
    Content type: Research Published on:

    The Correction to this article has been published in BMC Cancer 2024 24:487

  39. Prophylactic cranial irradiation (PCI) is part of standard care in limited-stage small cell lung cancer (SCLC) at present. As evidence from retrospective studies increases, the benefits of PCI for limited-stag...

    Authors: Mengyuan Chen, Runhua Li, Yue Kong, Lei Shi, Jing Wang, Yuezhen Wang, Yujin Xu, Yongling Ji and Xiao Hu
    Citation: BMC Cancer 2024 24:429
    Content type: Study Protocol Published on:

  40. This study aimed to conduct a comprehensive analysis, evaluating the prognostic significance of the baseline Advanced Lung Cancer Inflammation Index (ALI) and Gustave Roussy Immune (GRIm) Score in patients und...

    Authors: Hao Jiang, Borui Li, Min Wu, Qimei Wang and Yijin Li
    Citation: BMC Cancer 2024 24:428
    Content type: Research Published on:

  41. Although papillary thyroid cancer (PTC) patients are known to have an excellent prognosis, up to 30% of patients experience disease recurrence after initial treatment. Accurately predicting disease prognosis r...

    Authors: Hongxi Wang, Chao Zhang, Qianrui Li, Tian Tian, Rui Huang, Jiajun Qiu and Rong Tian
    Citation: BMC Cancer 2024 24:427
    Content type: Research Published on:

  42. Colorectal cancer (CRC) is the 3rd most common malignancy with the liver being the most common site of metastases. The recurrence rate of colorectal liver metastases (CRLM) after liver resection (LR) is notabl...

    Authors: Yuan Tian, Yaoqun Wang, Ningyuan Wen, Shaofeng Wang, Bei Li and Geng Liu
    Citation: BMC Cancer 2024 24:426
    Content type: Research Published on:

  43. The objective of this study was to investigate the correlation between spleen density and the prognostic outcomes of patients who underwent curative resection for colorectal cancer (CRC).

    Authors: Yunzhou Xiao, Xiaoting Wen, Yingying Ying, Xiaoyan Zhang, Luyao Li, Zhongchu Wang, Miaoguang Su and Shouliang Miao
    Citation: BMC Cancer 2024 24:425
    Content type: Research Published on:

  44. Patients from non-small cell lung cancer (NSCLC) controlled clinical trials do not always reflect real-world heterogeneous patient populations. We designed a study to describe the real-world patient characteri...

    Authors: Hozefa A. Divan, Marisa A. Bittoni, Ashok Krishna and David P. Carbone
    Citation: BMC Cancer 2024 24:424
    Content type: Research Published on:

  45. Total thyroidectomy is the main line of treatment for papillary thyroid cancer. Central lymph node dissection (CLND) is still debatable. In this study, we aimed to correlate the central lymph node status with ...

    Authors: Shadi Awny, Ahmed Abdallah, Islam H Metwally, Khaled Abdelwahab, Mohammad Zuhdy, Omar Hamdy, Ahmed M Fareed and Khalid Atallah
    Citation: BMC Cancer 2024 24:423
    Content type: Research Published on:

  46. As comprehensive surgical management for gastric cancer becomes increasingly specialized and standardized, the precise differentiation between ≤T1 and ≥T2 gastric cancer before endoscopic intervention holds pa...

    Authors: Yuan Zhong, Yan-Yan Xiao, Jie-Yi Ye, Guo-Liang Jian and Wei-Jun Huang
    Citation: BMC Cancer 2024 24:422
    Content type: Systematic Review Published on:

  47. We designed this study based on both a physician practice survey and real-world patient data to: (1) evaluate clinical management practices in extensive-stage small cell lung cancer (ES-SCLC) among medical cen...

    Authors: Bertrand Mennecier, Jonathan Khalifa, Renaud Descourt, Laurent Greillier, Charles Naltet and Lionel Falchero
    Citation: BMC Cancer 2024 24:421
    Content type: Research Published on:

  48. Clear cell carcinoma of the kidney is a common urological malignancy characterized by poor patient prognosis and treatment outcomes. Modulation of vasculogenic mimicry in tumor cells alters the tumor microenvi...

    Authors: Yuming Gu, Qinqin Huang, Yun Wang, Haixia Wang, Zhenhua Xiang, Yu Xu, Xin Wang, Weiguo Liu and Aiju Wang
    Citation: BMC Cancer 2024 24:420
    Content type: Research Published on:

  50. This study aimed to develop and validate a machine learning (ML)-based fusion model to preoperatively predict Ki-67 expression levels in patients with head and neck squamous cell carcinoma (HNSCC) using multip...

    Authors: Weiyue Chen, Guihan Lin, Yongjun Chen, Feng Cheng, Xia Li, Jiayi Ding, Yi Zhong, Chunli Kong, Minjiang Chen, Shuiwei Xia, Chenying Lu and Jiansong Ji
    Citation: BMC Cancer 2024 24:418
    Content type: Research Published on:

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