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  1. Content type: Study protocol

    Despite the fact that the cost-effectiveness of robot-assisted radical cystectomy (RARC) is not yet proven, and open radical (ORC) cystectomy is recommended as the standard of care in patients with high-risk n...

    Authors: C. J. Wijburg, C. T. J. Michels, J. R. Oddens, J. P. C. Grutters, J. A. Witjes and M. M. Rovers

    Citation: BMC Cancer 2018 18:861

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  2. Content type: Research article

    The Ki67 Index has been extensively studied as a prognostic biomarker in breast cancer. However, its clinical adoption is largely hampered by the lack of a standardized method to assess Ki67 that limits inter-...

    Authors: Muhammad Khalid Khan Niazi, Caglar Senaras, Michael Pennell, Vidya Arole, Gary Tozbikian and Metin N. Gurcan

    Citation: BMC Cancer 2018 18:867

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  3. Content type: Research article

    Cancer risk is associated with serum iron levels. The aim of this study was to evaluate whether haematological parameters reflect serum iron levels and may also be associated with cancer risk.

    Authors: Niwansa Adris, Anita Chai Geik Chua, Matthew William Knuiman, Mark Laurence Divitini, Debbie Trinder and John Kevin Olynyk

    Citation: BMC Cancer 2018 18:863

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  4. Content type: Research article

    The MRE11/RAD50/NBS1 (MRN) complex plays an essential role in detecting and repairing double-stranded breaks, and thus the potential roles of MRE11, RAD50 and NBS1 proteins in the pathogenesis of various cance...

    Authors: Vincent Ho, Liping Chung, Amandeep Singh, Vivienne Lea, Askar Abubakar, Stephanie H. Lim, Weng Ng, Mark Lee, Paul de Souza, Joo-Shik Shin and Cheok Soon Lee

    Citation: BMC Cancer 2018 18:869

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  5. Content type: Study protocol

    Anthracycline chemotherapy agents are commonly used to treat breast cancer, but also result in cardiac injury, and potentially detrimental effects to vascular and skeletal muscle. Preclinical evidence demonstr...

    Authors: Amy A. Kirkham, D. Ian Paterson, Carla M. Prado, John M. Mackey, Kerry S. Courneya, Edith Pituskin and Richard B. Thompson

    Citation: BMC Cancer 2018 18:864

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  6. Content type: Research article

    Observational studies have reported conflicting results on the impact of mammography service screening programmes on the advanced breast cancer rate (ABCR), a correlation that was firmly established in randomi...

    Authors: M. J. M. Broeders, P. Allgood, S. W. Duffy, S. Hofvind, I. D. Nagtegaal, E. Paci, S. M. Moss and L. Bucchi

    Citation: BMC Cancer 2018 18:860

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  7. Content type: Research article

    The preoperative growth of human glioblastomas (GBMs) has been shown to vary among patients. In animal studies, angiogenesis has been linked to hypoxia and faster growth of GBM, however, its relation to the gr...

    Authors: Vilde Elisabeth Mikkelsen, Anne Line Stensjøen, Unn Sophie Granli, Erik Magnus Berntsen, Øyvind Salvesen, Ole Solheim and Sverre Helge Torp

    Citation: BMC Cancer 2018 18:862

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  8. Content type: Study protocol

    Breast cancer (BC) is the most frequent cancer in women with more than 70% of BC patients being treated with hormonal therapy (HT). Among these patients, some report difficulties in remembering what they are s...

    Authors: Mylène Duivon, Joy Perrier, Florence Joly, Idlir Licaj, Jean-Michel Grellard, Bénédicte Clarisse, Christelle Lévy, Philippe Fleury, Sophie Madeleine, Nicolas Lefèvre, Géraldine Rauchs, Grégory Lecouvey, Florence Fraisse, Fausto Viader, Francis Eustache, Béatrice Desgranges…

    Citation: BMC Cancer 2018 18:866

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  9. Content type: Research article

    Pulmonary imaging often identifies suspicious abnormalities resulting in supplementary diagnostic procedures. This study aims to investigate whether the metabolic fingerprint of plasma allows to discriminate b...

    Authors: K. Vanhove, P. Giesen, O. E. Owokotomo, L. Mesotten, E. Louis, Z. Shkedy, M. Thomeer and P. Adriaensens

    Citation: BMC Cancer 2018 18:868

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  10. Content type: Research article

    Although our previous study revealed lumbar punctured resveratrol could remarkably prolong the survival of rats bearing orthotopic glioblastomas, it also suggested the administration did not completely suppres...

    Authors: Xue Song, Xiao-Hong Shu, Mo-Li Wu, Xu Zheng, Bin Jia, Qing-You Kong, Jia Liu and Hong Li

    Citation: BMC Cancer 2018 18:871

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  11. Content type: Research article

    This was a prespecified secondary analysis of a randomized trial, which analyzed bone density following stereotactic body radiotherapy (SBRT) versus conventional three-dimensional conformal radiotherapy (3DCRT...

    Authors: Tanja Sprave, Vivek Verma, Robert Förster, Ingmar Schlampp, Katharina Hees, Thomas Bruckner, Tilman Bostel, Rami Ateyah El Shafie, Thomas Welzel, Nils Henrik Nicolay, Jürgen Debus and Harald Rief

    Citation: BMC Cancer 2018 18:859

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  12. Content type: Research article

    The value of hospital registries for describing treatment and survival outcomes for vulval cancer was investigated. Hospital registry data from four major public hospitals in 1984–2016 were used because popula...

    Authors: David Roder, Margaret Davy, Sid Selva-Nayagam, Sellvakumaram Paramasivam, Jacqui Adams, Dorothy Keefe, Ian Olver, Caroline Miller, Elizabeth Buckley, Kate Powell, Kellie Fusco, Dianne Buranyi-Trevarton and Martin K. Oehler

    Citation: BMC Cancer 2018 18:858

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  13. Content type: Research article

    Metastatic melanoma is an aggressive form of skin cancer that evades various anti-cancer treatments including surgery, radio-,immuno- and chemo-therapy. TRAIL-induced apoptosis is a desirable method to treat m...

    Authors: Radhika S. Saraf, Aniruddha Datta, Chao Sima, Jianping Hua, Rosana Lopes and Michael Bittner

    Citation: BMC Cancer 2018 18:855

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  14. Content type: Research article

    Melanoma is one of the most invasive and aggressive types of cancer with a very poor prognosis. Surgery remains the most efficient treatment prior melanoma invasion and metastasis formation. However, therapy b...

    Authors: Myra O. Villareal, Yuki Sato, Kyoko Matsuyama and Hiroko Isoda

    Citation: BMC Cancer 2018 18:856

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    The Correction to this article has been published in BMC Cancer 2018 18:902

  15. Content type: Research article

    Gastric cancer (GC) is one of the most common malignant diseases with high morbidity and mortality, especially in Asian countries. During the GC developing progress, TIPE2, a member of TNF-alpha induced protei...

    Authors: Wenming Liu, Yanyun Fan, Ying Shi, Zhenhe Lin, Xiaoxiao Huang, Wei Huang, Dongyan Shen and Zhongquan Qi

    Citation: BMC Cancer 2018 18:857

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  16. Content type: Research article

    It has been shown that the expression of potassium channel tetramerization domain containing 12 (KCTD12) as a regulator of GABAB receptor signaling is reversely associated with gastrointestinal stromal tumors....

    Authors: Mohammad Reza Abbaszadegan, Negin Taghehchian, Liping Li, Azadeh Aarabi and Meysam Moghbeli

    Citation: BMC Cancer 2018 18:853

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  17. Content type: Study protocol

    Bleomycin, etoposide, and cisplatin (BEP) chemotherapy administered every 3 weeks for 4 cycles remains the standard first line treatment for patients with intermediate- and poor-risk metastatic germ cell tumou...

    Authors: Nicola J. Lawrence, Howard Chan, Guy Toner, Martin R. Stockler, Andrew Martin, Sonia Yip, Nicole Wong, Annie Yeung, Danish Mazhar, Farzana Pashankar, Lindsay Frazier, Ray McDermott, Roderick Walker, Hsiang Tan, Ian D. Davis and Peter Grimison

    Citation: BMC Cancer 2018 18:854

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  18. Content type: Study protocol

    Neoadjuvant chemotherapy (NACT) is a standard approach of the multidisciplinary treatment of breast cancer. Depending on the biological subtype a pathological complete response in the breast (bpCR) can be achi...

    Authors: Joerg Heil, Peter Sinn, Hannah Richter, André Pfob, Benedikt Schaefgen, André Hennigs, Fabian Riedel, Bettina Thomas, Marc Thill, Markus Hahn, Jens-Uwe Blohmer, Sherko Kuemmel, Maria Margarete Karsten, Mattea Reinisch, John Hackmann, Toralf Reimer…

    Citation: BMC Cancer 2018 18:851

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  19. Content type: Research article

    Efficiency of colorectal carcinoma treatment by chemotherapy is diminished as the resistance develops over time in patients. The same holds true for 5-fluorouracil, the drug used in first line chemotherapy of ...

    Authors: Erika Durinikova, Zuzana Kozovska, Martina Poturnajova, Jana Plava, Zuzana Cierna, Andrea Babelova, Roman Bohovic, Silvia Schmidtova, Miroslav Tomas, Lucia Kucerova and Miroslava Matuskova

    Citation: BMC Cancer 2018 18:848

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  20. Content type: Research article

    Numerous studies have investigated the relationship between COX-2 8473 T > C polymorphism and cancer susceptibility, however, the results remain controversial. Therefore, we carried out the present meta-analysis ...

    Authors: Qiuping Li, Chao Ma, Zhihui Zhang, Suhua Chen, Weiguo Zhi, Lei Zhang, Guoyao Zhang, Lei Shi, Fei Cao and Tianjiang Ma

    Citation: BMC Cancer 2018 18:847

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  21. Content type: Research article

    Tamoxifen treatment of estrogen receptor (ER)-positive breast cancer reduces mortality by 31%. However, over half of advanced ER-positive breast cancers are intrinsically resistant to tamoxifen and about 40% w...

    Authors: Susanne Hultsch, Matti Kankainen, Lassi Paavolainen, Ruusu-Maaria Kovanen, Elina Ikonen, Sara Kangaspeska, Vilja Pietiäinen and Olli Kallioniemi

    Citation: BMC Cancer 2018 18:850

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  22. Content type: Research article

    Chondrosarcoma is the second most frequent primary malignant bone tumor. Treatment is mainly based on surgery. In general, wide resection is advocated at least in G2 and G3 tumors. But which margins should be ...

    Authors: Julian Fromm, Alexander Klein, Andrea Baur-Melnyk, Thomas Knösel, Lars Lindner, Christof Birkenmaier, Falk Roeder, Volkmar Jansson and Hans Roland Dürr

    Citation: BMC Cancer 2018 18:849

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  23. Content type: Study protocol

    The majority of patients undergoing hepatectomy for hepatocellular carcinoma (HCC) suffer from underlying liver disease and are exposed to the risk of postoperative ascites, which is favored by an imbalance be...

    Authors: Kayvan Mohkam, Michel Rayar, Jean-Philippe Adam, Fabrice Muscari, Agnès Rode, Philippe Merle, Pierre Pradat, Stéphanie Bauler, Isabelle Delfour, Laurence Chiche, Christian Ducerf, Karim Boudjema, Mickaël Lesurtel, Christophe Laurent and Jean-Yves Mabrut

    Citation: BMC Cancer 2018 18:844

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  24. Content type: Research article

    Chronic inflammation and repeated infection with Opisthorchis viverrini (O. viverrini) induces intrahepatic cholangiocarcinoma (ICC). Inflammatory cytokines such as interleukin (IL) and tumor necrosis factor (TNF...

    Authors: Supannee Promthet, Nopparat Songserm, Somkiattiyos Woradet, Chamsai Pientong, Tipaya Ekalaksananan, Surapon Wiangnon and Akhtar Ali

    Citation: BMC Cancer 2018 18:846

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  25. Content type: Study protocol

    Routine assessment and clinical utilisation of patient-reported outcome (PRO) measures can lead to improved patient outcomes. The PROMPT-Care eHealth system facilitates PRO data capture from cancer patients, d...

    Authors: Afaf Girgis, Ivana Durcinoska, Martha Gerges, Nasreen Kaadan, Anthony Arnold, Joseph Descallar and Geoff P. Delaney

    Citation: BMC Cancer 2018 18:845

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  26. Content type: Research article

    An increase in naturally-occurring porphyrins has been described in the blood of subjects bearing different kinds of tumors, including colorectal, and this is probably related to a systemic alteration of heme ...

    Authors: Manuela Lualdi, Adalberto Cavalleri, Luigi Battaglia, Ambrogio Colombo, Giulia Garrone, Daniele Morelli, Emanuele Pignoli, Elisa Sottotetti and Ermanno Leo

    Citation: BMC Cancer 2018 18:841

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  27. Content type: Case report

    High-grade spindle cell sarcomas are a subtype of rare, undifferentiated pleomorphic sarcomas (UPSs) for which diagnosis is difficult and no specific treatment strategies have been established. The limited pub...

    Authors: Ning Zhou, Reinhold Schäfer, Tao Li, Meiyu Fang and Luying Liu

    Citation: BMC Cancer 2018 18:842

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  28. Content type: Debate

    Circular RNAs are a new class of endogenous non-coding RNA that can function as crucial regulators of diverse cellular processes. The diverse types of circular RNAs with varying cytogenetics in cancer have als...

    Authors: Zikang Zhang, Qing Xie, Dongmei He, Yuan Ling, Yuchao Li, Jiangbin Li and Hua Zhang

    Citation: BMC Cancer 2018 18:834

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  29. Content type: Research article

    Breast (mammary) cancers in human (BC) and canine (CMT) patients share clinical, pathological, and molecular similarities that suggest dogs may be a useful translational model. Many cancers, including BC, shed...

    Authors: Eric J. Fish, Kristopher J. Irizarry, Patricia DeInnocentes, Connor J. Ellis, Nripesh Prasad, Anthony G. Moss and R. Curt Bird

    Citation: BMC Cancer 2018 18:832

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  30. Content type: Research article

    To evaluate the role of blood vascular endothelial growth factor (VEGF) kinetics in patients with locally advanced esophageal squamous cell carcinoma (ESCC) receiving curative concurrent chemoradiotherapy (CCRT).

    Authors: Yen-Hao Chen, Hung-I Lu, Chien-Ming Lo, Yu-Ming Wang, Shang-Yu Chou, Chang-Chun Hsiao, Chao-Cheng Huang, Li-Hsueh Shih, Su-Wei Chen and Shau-Hsuan Li

    Citation: BMC Cancer 2018 18:837

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  31. Content type: Research article

    The aim of this study was to evaluate the early anti-tumor efficiency of different therapeutic agents with a combination of multi-b-value DWI, DCE-MRI and texture analysis.

    Authors: Ming Meng, Huadan Xue, Jing Lei, Qin Wang, Jingjuan Liu, Yuan Li, Ting Sun, Haiyan Xu and Zhengyu Jin

    Citation: BMC Cancer 2018 18:833

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  32. Content type: Research article

    Oxidative stress induces various intracellular damage, which might be correlated with tumorigenesis. Accumulated oxidative stresses might inactivate protein tyrosine phosphatase (PTP) by oxidizing it, and indu...

    Authors: Usama Khamis Hussein, Ho Sung Park, Jun Sang Bae, Kyoung Min Kim, Yun Jo Chong, Chan Young Kim, Keun Sang Kwon, Myoung Ja Chung, Ho Lee, Myoung Jae Kang, Woo Sung Moon and Kyu Yun Jang

    Citation: BMC Cancer 2018 18:836

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  33. Content type: Research article

    Pleomorphic liposarcoma (PLPS) is a rare, heterogeneous and an aggressive variant of liposarcoma. Therefore, individualized therapy is urgently needed. Our recent reports suggest that trabectedin (TRAB) is eff...

    Authors: Tasuku Kiyuna, Yasunori Tome, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Kentaro Miyake, Masuyo Miyake, Yunfeng Li, Scott D. Nelson, Sarah M. Dry, Arun S. Singh, Tara A. Russell, Irmina Elliott, Shree Ram Singh, Fuminori Kanaya, Fritz C. Eilber…

    Citation: BMC Cancer 2018 18:840

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  34. Content type: Research article

    This study explored the effect of liver resection on perioperative circulating tumor cells (CTCs) and found that the prognostic significance of surgery was associated with changes in CTC counts in patients wit...

    Authors: Jing-jing Yu, Wei Xiao, Shui-lin Dong, Hui-fang Liang, Zhi-wei Zhang, Bi-xiang Zhang, Zhi-yong Huang, Yi-fa Chen, Wan-guang Zhang, Hong-ping Luo, Qian Chen and Xiao-ping Chen

    Citation: BMC Cancer 2018 18:835

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  35. Content type: Case report

    Metastatic breast cancer (MBC) rest an incurably disease associated with bad prognosis and a median overall survival of 23–31 months. There are several treatment options including chemotherapy and sometimes en...

    Authors: Jean-David Fumet, Mark Wickre, Jean-Philippe Jacquot, Marie-Helene Bizollon, Adrien Melis, André Vanoli and Erika Viel

    Citation: BMC Cancer 2018 18:839

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  36. Content type: Research article

    Nucleophosmin is a non-ribosomal nucleolar phosphoprotein that is found primarily in the nucleolus region of cell nucleus, plays multiple important roles in tumor processes. Accumulated previous studies have r...

    Authors: Siying Chen, Hairong He, Yan Wang, Leichao Liu, Yang Liu, Haisheng You, Yalin Dong and Jun Lyu

    Citation: BMC Cancer 2018 18:838

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  37. Content type: Study protocol

    Seroma formation is a common complication after mastectomy and is associated with delayed wound healing, infection, skin flap necrosis, patient discomfort and repeated visits to the out patient clinic to deal ...

    Authors: J. van Bastelaar, R. Granzier, L. M. van Roozendaal, G. Beets, C. D. Dirksen and Y. Vissers

    Citation: BMC Cancer 2018 18:830

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  38. Content type: Research article

    Neck dissection is standard in surgical management of oral squamous cell carcinomas (oscc). However, the immunologic link between primary tumor and lymph nodes is insufficiently understood. Galectin 3 (Gal3) p...

    Authors: Falk Wehrhan, Maike Büttner-Herold, Luitpold Distel, Jutta Ries, Patrick Moebius, Raimund Preidl, Carol I. Geppert, Friedrich W. Neukam, Marco Kesting and Manuel Weber

    Citation: BMC Cancer 2018 18:823

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  39. Content type: Technical advance

    Gene fusion events resulting from chromosomal rearrangements play an important role in initiation of lung adenocarcinoma. The recent association of four oncogenic driver genes, ALK, ROS1, RET, and NTRK1, as lung ...

    Authors: Cecily P. Vaughn, José Luis Costa, Harriet E. Feilotter, Rosella Petraroli, Varun Bagai, Anna Maria Rachiglio, Federica Zito Marino, Bastiaan Tops, Henriette M. Kurth, Kazuko Sakai, Andrea Mafficini, Roy R. L. Bastien, Anne Reiman, Delphine Le Corre, Alexander Boag, Susan Crocker…

    Citation: BMC Cancer 2018 18:828

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  40. Content type: Research article

    Gastrin is an important gastrointestinal hormone produced primarily by G-cells in the antrum of the stomach. It normally regulates gastric acid secretion and is implicated in a number of human disease states, ...

    Authors: Li-Li Meng, Jing-Long Wang, Shu-Ping Xu, Li-Dong Zu, Zhao-Wen Yan, Jian-Bing Zhang, Ya-Qin Han and Guo-Hui Fu

    Citation: BMC Cancer 2018 18:824

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  41. Content type: Research article

    Practical and reliable genotyping procedures with a considerable number of samples are required not only for risk-adapted therapeutic strategies, but also for stratifying patients into future clinical trials f...

    Authors: Tomoya Yokota, Masakuni Serizawa, Ayumu Hosokawa, Kimihide Kusafuka, Keita Mori, Toshiro Sugiyama, Yasuhiro Tsubosa and Yasuhiro Koh

    Citation: BMC Cancer 2018 18:826

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  42. Content type: Research article

    Core needle biopsy (CNB) is a standard diagnostic procedure in the setting of breast cancer screening. However, CNB may result in the borderline diagnoses of lesion of uncertain malignant potential (B3). The a...

    Authors: Christiane Richter-Ehrenstein, Katharina Maak, Sonja Röger and Tilman Ehrenstein

    Citation: BMC Cancer 2018 18:829

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  43. Content type: Case report

    Pneumatosis intestinalis (PI) is a rare complication of chemotherapy, characterized by multiple gas accumulations within the bowel wall.

    Authors: Hironori Uruga, Shuhei Moriguchi, Yui Takahashi, Kazumasa Ogawa, Kyoko Murase, Sayaka Mochizuki, Shigeo Hanada, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa and Kazuma Kishi

    Citation: BMC Cancer 2018 18:825

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  44. Content type: Research article

    Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS...

    Authors: Seyed Hamidreza Mahmoudpour, Obul Reddy Bandapalli, Miguel Inácio da Silva Filho, Chiara Campo, Kari Hemminki, Hartmut Goldschmidt, Maximilian Merz and Asta Försti

    Citation: BMC Cancer 2018 18:820

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  45. Content type: Research article

    Colorectal cancer (CRC) remains a leading cause of death worldwide. Utilizing cisplatin in CRC is correlated with severe adverse effects and drug-resistance. Combined anticancer drug-treatment, along with, the...

    Authors: Mona M. Saber, Abdulaziz M. Al-mahallawi, Noha N. Nassar, Björn Stork and Samia A. Shouman

    Citation: BMC Cancer 2018 18:822

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  46. Content type: Research article

    Hypoxia is a hallmark of the solid tumor microenvironment and is associated with poor outcomes in cancer patients. The present study was performed to investigate mechanisms underlying the hypoxia-induced pheno...

    Authors: Myung-Chul Kim, Sung-Hyun Hwang, Na-Yon Kim, Hong-Seok Lee, Sumin Ji, Yeseul Yang and Yongbaek Kim

    Citation: BMC Cancer 2018 18:819

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