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  1. Content type: Research article

    Bladder cancer is the 7th cause of death from cancer in men and 10th in women. Metastatic patients have a poor prognosis with a median overall survival of 14 months. Until recently, vinflunine was the only sec...

    Authors: Marina Pulido, Guilhem Roubaud, Anne-Laure Cazeau, Hakim Mahammedi, Lionel Vedrine, Florence Joly, Loic Mourey, Christian Pfister, Alejandro Goberna, Barbara Lortal, Carine Bellera, Philippe Pourquier and Nadine Houédé

    Citation: BMC Cancer 2018 18:194

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  2. Content type: Research article

    Treatment with Bacillus Calmette-Guérin (BCG) is the gold standard adjuvant immunotherapy of non-muscle invasive bladder cancer (NMIBC), although it fails in one third of the patients. NMIBC expresses two tumor-a...

    Authors: Paulo F. Severino, Mariana Silva, Mylene Carrascal, Nadia Malagolini, Mariella Chiricolo, Giulia Venturi, Roberto Barbaro Forleo, Annalisa Astolfi, Mariangela Catera, Paula A. Videira and Fabio Dall’Olio

    Citation: BMC Cancer 2018 18:198

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  3. Content type: Research article

    Lung cancer patients with an activating mutation in the EGFR (epidermal growth factor receptor) can develop resistance to erlotinib treatment, which is often mediated by the T790M resistance mutation in EGFR. ...

    Authors: Christina Demuth, Anne Tranberg Madsen, Britta Weber, Lin Wu, Peter Meldgaard and Boe Sandahl Sorensen

    Citation: BMC Cancer 2018 18:191

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  4. Content type: Research article

    Physical activity has been implicated as a risk factor in the development of testicular cancer (TC), but the relationship remains controversial. This systematic review pooled available evidence regarding this ...

    Authors: Stephanie Huang, Virginia Signal, Diana Sarfati, Caroline Shaw, James Stanley, Katherine McGlynn and Jason Gurney

    Citation: BMC Cancer 2018 18:189

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  5. Content type: Research article

    Subjects with elevated Epstein-Barr virus (EBV) immunoglobulin A (IgA) titers have a higher risk of developing nasopharyngeal carcinoma (NPC), indicating that reactivation of EBV in the local mucosa might be i...

    Authors: Yufeng Chen, Yifei Xu, Weilin Zhao, Xue Xiao, Xiaoying Zhou, Longde Lin, Tingting Huang, Jian Liao, Yancheng Li, Xiaoyun Zeng, Guangwu Huang, Weimin Ye and Zhe Zhang

    Citation: BMC Cancer 2018 18:190

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  6. Content type: Research article

    To evaluate survival data and local tumor control after transarterial chemoembolization in two groups with different embolization protocols for the treatment of HCC patients.

    Authors: Tatjana Gruber-Rouh, Cornelia Schmitt, Nagy N. N. Naguib, N. A. Nour-Eldin, Katrin Eichler, Martin Beeres and Thomas J. Vogl

    Citation: BMC Cancer 2018 18:188

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  7. Content type: Research article

    Serious neurological adverse events (NAE) have occurred during treatment with high-dose thiotepa regimens of children with high-risk solid tumours. The objective was to assess the incidence of NAE related to h...

    Authors: Christophe Maritaz, Francois Lemare, Agnes Laplanche, Sylvie Demirdjian, Dominique Valteau-Couanet and Christelle Dufour

    Citation: BMC Cancer 2018 18:177

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  8. Content type: Research article

    Several efforts have been focused on identification of pathways involved in malignancy, progression, and response to treatment in Glioblastoma (GB). Overexpression of PKCε was detected in histological samples ...

    Authors: Ewa Toton, Aleksandra Romaniuk, Natalia Konieczna, Johann Hofmann, Jan Barciszewski and Maria Rybczynska

    Citation: BMC Cancer 2018 18:185

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  9. Content type: Research article

    Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies due to sophisticated genetic mutations and epigenetic dysregulation. MicroRNAs (miRNAs), a class of small non-coding RNAs, ar...

    Authors: Laixi Bi, Bin Zhou, Haiying Li, Licai He, Chunjing Wang, Zhonggai Wang, Liqing Zhu, Mengqian Chen and Shenmeng Gao

    Citation: BMC Cancer 2018 18:182

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  10. Content type: Research article

    While a range of common genetic variants have been identified to be associated with risk of sporadic breast cancer in several Western studies, little is known about their role in South Asian populations. Our o...

    Authors: Nirmala Dushyanthi Sirisena, Adebowale Adeyemo, Anchala I. Kuruppu, Nilaksha Neththikumara, Nilakshi Samaranayake and Vajira H. W. Dissanayake

    Citation: BMC Cancer 2018 18:180

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  11. Content type: Research article

    The clinical utility and prognostic impact of presumed primary breast or ovarian cancer among patients with an unfavorable subset of cancer of unknown primary site (CUP) remains unclear. We aimed to evaluate t...

    Authors: Makoto Kodaira, Kan Yonemori, Tatsunori Shimoi, Akihiko Yoshida, Masayuki Yoshida, Atsuko Kitano, Akihiko Shimomura, Mayu Yunokawa, Chikako Shimizu, Yuichi Takiguchi, Yasuhiro Fujiwara and Kenji Tamura

    Citation: BMC Cancer 2018 18:176

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  12. Content type: Research article

    Patients with advanced lung cancer (LC) or malignant pleural mesothelioma (MPM) exhibit limitation of exercise capacities and alteration of quality of life (QoL) induced by cancer and its treatment. Few studie...

    Authors: Cecile Olivier, Jean-Marie Grosbois, Alexis B. Cortot, Sophie Peres, Christophe Heron, Julie Delourme, Marianne Gierczynski, Anne Hoorelbeke, Arnaud Scherpereel and Olivier Le Rouzic

    Citation: BMC Cancer 2018 18:178

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  13. Content type: Study protocol

    There is now a renewed interest in cancer vaccines. Patients responding to immune checkpoint blockade usually bear tumors that are heavily infiltrated by T cells and express a high load of neoantigens, indicat...

    Authors: Sheeba K. Thomas, Soung-chul Cha, D. Lynne Smith, Kun Hwa Kim, Sapna R. Parshottam, Sheetal Rao, Michael Popescu, Vincent Y. Lee, Sattva S. Neelapu and Larry W. Kwak

    Citation: BMC Cancer 2018 18:187

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  14. Content type: Research article

    Chronic inflammatory conditions are associated with higher tumor incidence through epigenetic and genetic alterations. Here, we focused on an association between an inflammation marker, C-reactive-protein (CRP...

    Authors: Masanori Nojima, Motoki Iwasaki, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Teruhiko Yoshida and Shoichiro Tsugane

    Citation: BMC Cancer 2018 18:184

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  15. Content type: Study protocol

    Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6...

    Authors: A. Arjona-Sánchez, P. Barrios, E. Boldo-Roda, B. Camps, J. Carrasco-Campos, V. Concepción Martín, A. García-Fadrique, A. Gutiérrez-Calvo, R. Morales, G. Ortega-Pérez, E. Pérez-Viejo, A. Prada-Villaverde, J. Torres-Melero, E. Vicente, P. Villarejo-Campos, J. M. Sánchez-Hidalgo…

    Citation: BMC Cancer 2018 18:183

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  16. Content type: Study protocol

    Recent studies demonstrated the efficacy of S-1-based adjuvant chemotherapy administered for six months after curative surgery for stage III gastric cancer; however, it is unproven whether this type of combina...

    Authors: Tsutomu Namikawa, Hiromichi Maeda, Hiroyuki Kitagawa, Koji Oba, Akihito Tsuji, Takaki Yoshikawa, Michiya Kobayashi and Kazuhiro Hanazaki

    Citation: BMC Cancer 2018 18:186

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  17. Content type: Research article

    Tumor heterogeneity in breast cancer tumors is today widely recognized. Most of the available knowledge in genetic variation however, relates to the primary tumor while metastatic lesions are much less studied...

    Authors: Una Kjällquist, Rikard Erlandsson, Nicholas P. Tobin, Amjad Alkodsi, Ikram Ullah, Gustav Stålhammar, Eva Karlsson, Thomas Hatschek, Johan Hartman, Sten Linnarsson and Jonas Bergh

    Citation: BMC Cancer 2018 18:174

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  18. Content type: Research article

    Nijmegen breakage syndrome 1 (NBS1), as a key protein in the DNA double-strand breaks (DSBs) repair pathway, plays an important role in maintaining genomic stability. Although single nucleotide polymorphisms (SNP...

    Authors: Xinmei Hu, Juan Liao, Huiliu Zhao, Feng Chen, Xuefeng Zhu, Jiangheng Li and Qingqing Nong

    Citation: BMC Cancer 2018 18:175

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  19. Content type: Case report

    Brain metastases from gastric cancer are difficult to treat and their prognosis is poor. Despite various possible treatments, the survival rate of such patients is still unsatisfactory; therefore, new treatmen...

    Authors: Min-joo Ahn, Kanghan Lee, Kyung Hwa Lee, Jin Woong Kim, In-Young Kim and Woo Kyun Bae

    Citation: BMC Cancer 2018 18:173

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  20. Content type: Research article

    In addition to tumor characteristics and lifestyle factors, cancer relapses are often related to the risk of death but have not been jointly studied. We investigate the prognostic factors of recurrent events a...

    Authors: Alexandre Lafourcade, Mathilde His, Laura Baglietto, Marie-Christine Boutron-Ruault, Laure Dossus and Virginie Rondeau

    Citation: BMC Cancer 2018 18:171

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  21. Content type: Research article

    Estimates of cancer prevalence are widely based on limited duration, often including patients living after a cancer diagnosis made in the previous 5 years and less frequently on complete prevalence (i.e., incl...

    Authors: Stefano Guzzinati, Saverio Virdone, Roberta De Angelis, Chiara Panato, Carlotta Buzzoni, Riccardo Capocaccia, Silvia Francisci, Anna Gigli, Manuel Zorzi, Giovanna Tagliabue, Diego Serraino, Fabio Falcini, Claudia Casella, Antonio Giampiero Russo, Fabrizio Stracci, Bianca Caruso…

    Citation: BMC Cancer 2018 18:169

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  22. Content type: Research article

    The optimal first-line chemotherapy for ovarian carcinosarcoma has not yet been determined. We therefore sought to determine the progression-free survival (PFS) and overall survival (OS) for patients with ovar...

    Authors: Melissa Brackmann, Marina Stasenko, Shitanshu Uppal, Jake Erba, R. Kevin Reynolds and Karen McLean

    Citation: BMC Cancer 2018 18:172

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