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  1. Breast cancer survivors have a unique risk for negative health outcomes. Engaging in routine physical activity (PA) can reduce these risks. However, PA levels are low among this population. Narrative visualiza...

    Authors: Jason R. Bentley, Xiaoying Yu, Amol M. Karmarkar, Brian Downer, John Prochaska and Elizabeth J. Lyons
    Citation: BMC Cancer 2022 22:553
  2. Homologous recombination deficiency (HRD) is a molecular biomarker for administrating PARP inhibitor (PARPi) or platinum-based (Pt) chemotherapy. The most well-studied mechanism of causing HRD is pathogenic BRCA1...

    Authors: Hao Wen, Zheng Feng, Yutong Ma, Rui Liu, Qiuxiang Ou, Qinhao Guo, Yi Shen, Xue Wu, Yang Shao, Hua Bao and Xiaohua Wu
    Citation: BMC Cancer 2022 22:550
  3. This study was conducted to evaluate the prognostic significance of different molecular typing methods and immune status based on RNA sequencing (RNA-seq) in hormone receptor (HR)-positive and human epidermal ...

    Authors: Xinyu Ren, Yu Song, Yanna zhang, Huanwen Wu, Longyun Chen, Junyi Pang, Liangrui Zhou, Songjie Shen and Zhiyong Liang
    Citation: BMC Cancer 2022 22:548
  4. During the cancer treatment path, cancer patients use numerous drugs, including anticancer, supportive, and other prescribed medications, along with herbs and certain products. This puts them at risk of signif...

    Authors: Amer A. Koni, Maisa A. Nazzal, Bushra A. Suwan, Samah S. Sobuh, Najiya T. Abuhazeem, Asil N. Salman, Husam T. Salameh, Riad Amer and Sa’ed H. Zyoud
    Citation: BMC Cancer 2022 22:547
  5. Body mass index (BMI) and cardiometabolic comorbidities such as cardiovascular disease and type 2 diabetes have been studied as negative prognostic factors in cancer survival, but possible dependencies in the ...

    Authors: Mirjam Kohls, Heinz Freisling, Hadrien Charvat, Isabelle Soerjomataram, Vivian Viallon, Veronica Davila-Batista, Rudolf Kaaks, Renée Turzanski-Fortner, Krasimira Aleksandrova, Matthias B. Schulze, Christina C. Dahm, Helene Tilma Vistisen, Agnetha Linn Rostgaard-Hansen, Anne Tjønneland, Catalina Bonet, Maria-Jose Sánchez…
    Citation: BMC Cancer 2022 22:546
  6. Laryngeal squamous cell carcinoma (LSCC) is the most common squamous cell carcinoma. Though significant effort has been focused on molecular pathogenesis, development, and recurrence of LSCC, little is known ...

    Authors: Lvsheng Qian, Tingting Ni, Bing Fei, Hui Sun and Haosheng Ni
    Citation: BMC Cancer 2022 22:545
  7. The interaction between tumor microenvironment (TME) and tumors offers various targets in mounting anti-tumor immunotherapies. However, the prognostic biomarkers in endometrial carcinoma (EC) are still limited...

    Authors: Heng Ma, Peng-hui Feng, Shuang-ni Yu, Zhao-hui Lu, Qi Yu and Jie Chen
    Citation: BMC Cancer 2022 22:543

    The Correction to this article has been published in BMC Cancer 2022 22:592

  8. To investigate pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) safety and efficacy in preventing hematological toxicity during concurrent chemoradiotherapy (CCRT) for small-cell...

    Authors: Cunliang Wang, Shouhui Zhu, Chuanwang Miao, Yu Wang, Jiazhen Chen, Shuanghu Yuan and Xudong Hu
    Citation: BMC Cancer 2022 22:542
  9. Pleural invasion (PL) has been regarded as an unfavorable prognostic factor for non-small cell lung cancer (NSCLC). But there was no agreement on the optimal surgical extent in NSCLC patients with PL. We aimed...

    Authors: Xue Song, Yangyang Xie, Yurou Zhu and Yafang Lou
    Citation: BMC Cancer 2022 22:541
  10. Several studies investigated the utility of inflammation and nutritional markers in predicting the prognosis in patients with gastric cancer; however, the markers with the best predictive ability remain unclea...

    Authors: Tomoyuki Matsunaga, Hiroaki Saito, Tomohiro Osaki, Sadamu Takahashi, Akemi Iwamoto, Kenji Fukuda, Kenjiro Taniguchi, Hirohiko Kuroda, Tsutomu Takeuchi, Kenji Sugamura, Kenichi Sumi, Kuniyuki Katano, Yuji Shishido, Kozo Miyatani and Yoshiyuki Fujiwara
    Citation: BMC Cancer 2022 22:540
  11. Bronchoscopy can be a distress for the patient. There have been few studies on the combination of sedatives and opioids. The aim of this study was to demonstrate the usefulness and safety of administration of ...

    Authors: Masahiro Katsurada, Motoko Tachihara, Naoko Katsurada, Naoya Takata, Hiroki Sato, Chihiro Mimura, Junya Yoshioka, Koichi Furukawa, Masako Yumura, Takehiro Otoshi, Yuichiro Yasuda, Tatsunori Kiriu, Daisuke Hazama, Tatsuya Nagano, Masatsugu Yamamoto, Yoshihiro Nishimura…
    Citation: BMC Cancer 2022 22:539
  12. The standard of care treatment for soft tissue sarcoma of the extremities is a wide resection in combination with pre- or postoperative radiotherapy with high local control rates, sparing patients the necessit...

    Authors: D. Brügemann, B. Lehner, M. Kieser, J. Krisam, A. Hommertgen, C. Jaekel, S. B. Harrabi, K. Herfarth, G. Mechtesheimer, O. Sedlaczek, G. Egerer, A. Geisbüsch, M. Uhl, J. Debus and K. Seidensaal
    Citation: BMC Cancer 2022 22:538
  13. Perioperative chemotherapy and surgery are a standard of care for patients with resectable gastric or gastroesophageal junction (GEJ) adenocarcinoma. However, the prognosis remains poor for this population. Th...

    Authors: Mélanie Dos Santos, Justine Lequesne, Alexandra Leconte, Stéphane Corbinais, Aurélie Parzy, Jean-Marc Guilloit, Sharmini Varatharajah, Pierre-Emmanuel Brachet, Marine Dorbeau, Dominique Vaur, Louis-Bastien Weiswald, Laurent Poulain, Corentin Le Gallic, Marie Castera-Tellier, Marie-Pierre Galais and Bénédicte Clarisse
    Citation: BMC Cancer 2022 22:537
  14. The French PRODIGE 7 trial, published on January 2021, has raised doubts about the specific survival benefit provided by HIPEC with oxaliplatin 460 mg/m2 (30 minutes) for the treatment of peritoneal metastases fr...

    Authors: Fernando Pereira, Angel Serrano, Israel Manzanedo, Estibalitz Pérez-Viejo, Santiago González-Moreno, Luis González-Bayón, Alvaro Arjona-Sánchez, Juan Torres, Isabel Ramos, Maria E. Barrios, Pedro Cascales, Rafael Morales, Enrique Boldó, Alfonso García-Fadrique, Xabier Arteaga, Alberto Gutierrez-Calvo…
    Citation: BMC Cancer 2022 22:536
  15. As opposed to observation of the neck, elective neck dissection has a survival benefit for cN0 oropharyngeal squamous cell carcinoma (OPSCC). However, there are limited date on level IV neck dissection in huma...

    Authors: Zirong Huo, Shuiting Fu, Chunyue Ma and Surui Sheng
    Citation: BMC Cancer 2022 22:535
  16. Several studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined effect of cardiovascular risk factors on the risk of breast cancer is stil...

    Authors: Xiaoqi Zeng, Shanshan Jiang, Simin Ruan, Lijun Zhu, Huining Lian, Minfeng Liu, Zhaoze Guo, Jingyun Guo, Changsheng Ye, Yunjiu Cheng and Jianyu Dong
    Citation: BMC Cancer 2022 22:534
  17. As a metastasis-related protein, NEDD9 has been reported in breast cancer (BC) metastasis research. However, there are few studies on the upstream regulators of NEDD9, especially involving the potential role o...

    Authors: Jiamin Zhou, Xianglin Sun, Xinyu Zhang, Huan Yang, Zhenglin Jiang, Qianqian Luo, Yifei Liu and Guohua Wang
    Citation: BMC Cancer 2022 22:533
  18. Access to cancer care is a problem that continues to plague refugees displaced from their home countries. The turbulent political crisis in Syria, which has led to millions of refugees seeking asylum in Turkey...

    Authors: Mutlay Sayan, Mehmet Fuat Eren, Sarah Sabrine Kilic, Ayse Kotek, Sedenay Oskeroglu Kaplan, Ozge Duran, Funda Cukurcayır, Ibrahim Babalıoglu, Ozlem Derinalp Or, Gul Aysen Ozturk, Celalettin Eroglu, Fatma Teke, Neslihan Kurtul, Tugce Kutuk, Beyhan Ceylaner Bicakci, Sukran Senyurek…
    Citation: BMC Cancer 2022 22:532
  19. Racial and ethnic disparities in outcomes for Black and Hispanic children with acute leukemia have been well documented, however little is known about the determinants of diagnostic delays in pediatric leukemi...

    Authors: Lucky Ding, Julia E. Szymczak, Erica Evans, Emma Canepa, Ashley E. Martin, Farah Contractor, Richard Aplenc, Galen Joseph and Lena E. Winestone
    Citation: BMC Cancer 2022 22:531
  20. Salivary biomarkers hold huge potential for the non-invasive diagnosis of oral squamous cell carcinoma. Angiogenic factors and matrix-metalloproteinases (MMPs) are highly expressed in OSCC tissue, but their ex...

    Authors: Meijuan Cai, Zhichao Zheng, Zhibao Bai, Kexiong Ouyang, Qiuyu Wu, Shaofen Xu, Lihuan Huang, Yingtong Jiang, Lijing Wang, Jie Gao, Janak L. Pathak and Lihong Wu
    Citation: BMC Cancer 2022 22:530
  21. There is a paucity of data regarding the prognostic influence of peripheral blood CD4+ T lymphopenia in non-small cell lung cancer (NSCLC). Therefore, we investigated the prognostic value of T lymphopenia in N...

    Authors: Guillaume Eberst, Dewi Vernerey, Caroline Laheurte, Aurélia Meurisse, Vincent Kaulek, Laurie Cuche, Pascale Jacoulet, Hamadi Almotlak, Jean Lahourcade, Marie Gainet-Brun, Elizabeth Fabre, Françoise Le Pimpec-Barthes, Olivier Adotevi and Virginie Westeel
    Citation: BMC Cancer 2022 22:529
  22. Soft tissue sarcomas (STSs) are a heterogeneous group of cancers with over 100 described subtypes. While these cancers are infrequent, the prognosis is quite poor, particularly for those with stage IV metastat...

    Authors: Akira Kawai, Hiroyuki Narahara, Shunji Takahashi, Tomoki Nakamura, Hiroshi Kobayashi, Yasunori Megumi, Toshiyuki Matsuoka and Eisuke Kobayashi
    Citation: BMC Cancer 2022 22:528
  23. Cancer is the major cause of morbidity and mortality worldwide. The cancer burden varies within the regions of India posing great challenges in its prevention and control. The national burden assessment remain...

    Authors: Vaitheeswaran Kulothungan, Krishnan Sathishkumar, Sravya Leburu, Thilagavathi Ramamoorthy, Santhappan Stephen, Dharmappa Basavarajappa, Nifty Tomy, Rohith Mohan, Geetha R. Menon and Prashant Mathur
    Citation: BMC Cancer 2022 22:527
  24. A current critical need remains in the identification of prognostic and predictive markers in early breast cancer. It appears that a distinctive trait of cancer cells is their addiction to hyperactivation of r...

    Authors: Flora Nguyen Van Long, Audrey Lardy-Cleaud, Dimitri Carène, Caroline Rossoni, Frédéric Catez, Paul Rollet, Nathalie Pion, Déborah Monchiet, Agathe Dolbeau, Marjorie Martin, Valentin Simioni, Susan Bray, Doris Le Beherec, Fernanda Mosele, Ibrahim Bouakka, Amélie Colombe-Vermorel…
    Citation: BMC Cancer 2022 22:526
  25. Preoperative prediction of microsatellite instability (MSI) status in colorectal cancer (CRC) patients is of great significance for clinicians to perform further treatment strategies and prognostic evaluation....

    Authors: Mingliang Ying, Jiangfeng Pan, Guanghong Lu, Shaobin Zhou, Jianfei Fu, Qinghua Wang, Lixia Wang, Bin Hu, Yuguo Wei and Junkang Shen
    Citation: BMC Cancer 2022 22:524
  26. Runt-related transcription factor 1 (RUNX1) is a vital regulator of mammalian expression. Despite multiple pieces of evidence indicating that dysregulation of RUNX1 is a common phenomenon in human cancers, the...

    Authors: Zhouting Tuo, Ying Zhang, Xin Wang, Shuxin Dai, Kun Liu, Dian Xia, Jinyou Wang and Liangkuan Bi
    Citation: BMC Cancer 2022 22:523
  27. Cervical screening saves approximately 5000 lives annually in England. However, screening rates have been falling continuously, and coverage in London is particularly low (64.7%). While demographic predictors ...

    Authors: Gaby Judah, Faisal Dilib, Ara Darzi and Sarah Huf
    Citation: BMC Cancer 2022 22:522
  28. Patients have significantly lower QoL scores after pancreatic resection due to cancer in the physical and psychological domains compared to healthy controls or other cancer patients. Intensified physiotherapy ...

    Authors: Dirk Weyhe, Dennis Obonyo, Verena Uslar and Navid Tabriz
    Citation: BMC Cancer 2022 22:520
  29. Cytochrome P450 (CYP) and glutathione S transferases (GSTs) are important biotransforming enzymes responsible for detoxification of anticancer drugs and carcinogens. Polymorphisms in these enzymes may greatly ...

    Authors: Samina Naz Mukry, Aneeta Shahni, Uzma Zaidi and Tahir Sultan Shamsi
    Citation: BMC Cancer 2022 22:519
  30. Hepatocellular carcinoma (HCC) is one of the most prevalent types of cancer and is responsible for close to one million annual deaths globally. In Pakistan, HCC accounts for 10.7% of cancer incidence. Prior st...

    Authors: Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Janeen H. Trembley, Areeb Rizwan, Fatima Faraz, Syeda Alveena Shah, Mahrukh Farooqi, Naeem Mahmood Ashraf, Tayyaba Afsar, Ali Almajwal, Nawaf W. Alruwaili and Suhail Razak
    Citation: BMC Cancer 2022 22:518
  31. Transarterial chemoembolization (TACE) is the standard treatment for intermediate stage hepatocellular carcinoma (HCC) (Barcelona Clinic Liver Cancer [BCLC] B). However, it often leads to a poor prognosis and ...

    Authors: Satoshi Kobayashi, Taito Fukushima, Makoto Ueno, Satoshi Moriya, Makoto Chuma, Kazushi Numata, Kota Tsuruya, Shunji Hirose, Tatehiro Kagawa, Nobuhiro Hattori, Tsunamasa Watanabe, Kotaro Matsunaga, Michihiro Suzuki, Haruki Uojima, Hisashi Hidaka, Chika Kusano…
    Citation: BMC Cancer 2022 22:517
  32. Approximately 20–33% of all cancer patients are treated with acid-reducing agents (ARAs), most commonly proton pump inhibitors (PPIs), to reduce gastroesophageal reflux disease symptoms. Palbociclib and riboci...

    Authors: Kadir Eser, Arif Hakan Önder, Emel Sezer, Timuçin Çil, Ali İnal, Banu Öztürk, Vehbi Erçolak, Berna Bozkurt Duman, Halil Çelik, Tolga Köşeci and Oğuzhan Kesen
    Citation: BMC Cancer 2022 22:516
  33. Monitoring proteinuria is important for the management of patients with cancer treated with anti-vascular endothelial growth factor (VEGF) or anti-VEGF receptor (VEGFR) inhibitors (VEGF/Ri). Here we investigat...

    Authors: Michio Nakamura, Taro Funakoshi, Shigeki Kataoka, Takahiro Horimatsu, Yoshitaka Nishikawa, Takeshi Matsubara, Takuro Mizukami, Tomoyuki Goto, Kenji Tsuchihashi, Eishi Baba, Takehiko Tsumura, Yoshiaki Mihara, Tetsuya Hamaguchi, Motoko Yanagita and Manabu Muto
    Citation: BMC Cancer 2022 22:515
  34. Epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) are the current standard of care for advanced or metastatic non-small cell lung cancer (NSCLC) patients harboring EGFR activating mutation...

    Authors: Ziyi Xu, Chengcheng Liu, Yixiang Zhu, Zihua Zou, Tongji Xie, Puyuan Xing, Le Wang and Junling Li
    Citation: BMC Cancer 2022 22:514
  35. The revised 8th Edition American Joint Committee on Cancer (AJCC) Head and Neck Staging Manual distinguishes HPV-mediated from non-HPV-mediated oropharyngeal cancer (OpSCC). The objective was to analyze OpSCC ...

    Authors: X. J. David Lu, Emmanuel Jackson, Jason Chew, Sally Nguyen, Jonn Wu, Catherine F. Poh and Eitan Prisman
    Citation: BMC Cancer 2022 22:513
  36. Indian natural products have been anecdotally used for cancer treatment but with limited efficacy. To better understand their mechanism, we examined the publicly available data for the activity of Indian natur...

    Authors: Hari Sankaran, Simarjeet Negi, Lisa M. McShane, Yingdong Zhao and Julia Krushkal
    Citation: BMC Cancer 2022 22:512
  37. Better prognostic outcome is closely correlated with early detection of bladder cancer. Current non-invasive urianalysis relies on simultaneously testing multiple methylation markers to achieve relatively high...

    Authors: Leihong Deng, Haichao Chao, Huanhuan Deng, Zhaojun Yu, Rongsong Zhao, Longwu Huang, Yun Gong, Yueting Zhu, Qingping Wang, Feng Li, Lirong Liu, Lei He, Zhimin Tang, Caizhi Liao, Yan Qi, Xianshu Wang…
    Citation: BMC Cancer 2022 22:510
  38. To investigate the clinicopathological characteristics, diagnoses, treatments, and outcomes of a special type of gestational trophoblastic neoplasia (GTN) which only has extrauterine metastases without uterine...

    Authors: Jingnan Li, Yu Wang, Bingjian Lu, Weiguo Lu, Xing Xie and Yuanming Shen
    Citation: BMC Cancer 2022 22:509
  39. The MyPeBS study is an ongoing randomised controlled trial testing whether a risk-stratified breast cancer screening strategy is non-inferior, or eventually superior, to standard age-based screening at reducin...

    Authors: Alexandra Roux, Rachel Cholerton, Jonathan Sicsic, Nora Moumjid, David P. French, Paolo Giorgi Rossi, Corinne Balleyguier, Michal Guindy, Fiona J. Gilbert, Jean-Benoit Burrion, Xavier Castells, David Ritchie, Debbie Keatley, Camille Baron, Suzette Delaloge and Sandrine de Montgolfier
    Citation: BMC Cancer 2022 22:507
  40. Preoperative chemoradiotherapy (CRT) with CROSS regimen has been the recommended treatment for locally advanced esophageal squamous cell carcinoma (ESCC). The addition of programmed cell death protein 1 (PD-1)...

    Authors: Yang Yang, Li Zhu, Yan Cheng, Zhichao Liu, Xiaoyue Cai, Jinchen Shao, Ming Zhang, Jun Liu, Yifeng Sun, Yin Li, Jun Yi, Bentong Yu, Hongjing Jiang, Hezhong Chen, Hong Yang, Lijie Tan…
    Citation: BMC Cancer 2022 22:506
  41. A first pilot study showed that an image-guided navigation system could improve resection margin rates in locally advanced (LARC) and locally recurrent rectal cancer (LRRC) patients. Incremental surgical innov...

    Authors: Melanie Lindenberg, Astrid Kramer, Esther Kok, Valesca Retèl, Geerard Beets, Theo Ruers and Wim van Harten
    Citation: BMC Cancer 2022 22:504
  42. Many studies have recently reported the association of concomitant medications with the response and survival in patients with non-small-cell lung cancer (NSCLC) treated with cancer immunotherapy. However, the...

    Authors: Kazuki Takada, Mototsugu Shimokawa, Shinkichi Takamori, Shinichiro Shimamatsu, Fumihiko Hirai, Tetsuzo Tagawa, Tatsuro Okamoto, Motoharu Hamatake, Yuko Tsuchiya-Kawano, Kohei Otsubo, Koji Inoue, Yasuto Yoneshima, Kentaro Tanaka, Isamu Okamoto, Yoichi Nakanishi and Masaki Mori
    Citation: BMC Cancer 2022 22:503
  43. The National Comprehensive Cancer Network recommends that patients with hormone receptor-positive early breast cancer be considered for adjuvant endocrine therapy (ET) after primary treatment like surgical exc...

    Authors: Jacqueline Brown, Savannah Scardo, Michael Method, Dan Schlauch, Amanda Misch, Shaita Picard, Erika Hamilton, Suzanne Jones, Howard Burris and David Spigel
    Citation: BMC Cancer 2022 22:502
  44. Ewing sarcoma (ES) is sensitive to systemic therapy, including chemotherapy and anti-angiogenesis Tyrosine Kinase Inhibitors(aaTKIs). However, the prognosis of patients with metastatic disease remains poor. Re...

    Authors: Jie Xu, Xin Zhi, Lu Xie, Xin Sun, Xingyu Liu, Kuisheng Liu and Wei Guo
    Citation: BMC Cancer 2022 22:500
  45. Tubulin alpha-1c chain (TUBA1C), a subtype of α-tubulin, has been shown to be involved in cell proliferation and cell cycle progression in several cancers and to influence cancer development and prognosis. How...

    Authors: Xinyao Hu, Hua Zhu, Biao Chen, Xiaoqin He, Yang Shen, Xiaoyu Zhang, Yangtao Xu and Ximing Xu
    Citation: BMC Cancer 2022 22:498

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