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  1. Breast cancer (BC) is one of the most prevalent cancers worldwide but its etiology remains unclear. Obesity is recognized as a risk factor for BC, and many obesity-related genes may be involved in its occurren...

    Authors: Liyuan Liu, Wenli Zhai, Fei Wang, Lixiang Yu, Fei Zhou, Yujuan Xiang, Shuya Huang, Chao Zheng, Zhongshang Yuan, Yong He, Zhigang Yu and Jiadong Ji
    Citation: BMC Cancer 2022 22:1070
  2. The protein kinases CK2 and PIM-1 are involved in cell proliferation and survival, the cell cycle, and drug resistance, and they are found overexpressed in virtually all types of human cancer, including breast...

    Authors: Mirosława Koronkiewicz, Zygmunt Kazimierczuk and Andrzej Orzeszko
    Citation: BMC Cancer 2022 22:1069
  3. Tumor necrosis factor alpha-induced protein 2 (TNFAIP2), a TNFα-inducible gene, appears to participate in inflammation, immune response, hematopoiesis, and carcinogenesis. However, the potential role of TNFAIP2 i...

    Authors: Mei-si Lin, Hui-Yun Zhong, Rita Lok-Hay Yim, Qi-Yan Chen, Hong-ling Du, Hao-qi He, Ke Lin, Peng Zhao, Ru Gao, Fei Gao and Min-Yue Zhang
    Citation: BMC Cancer 2022 22:1068
  4. Tamoxifen is one of the fundamental pillars of adjuvant endocrine therapy for hormone receptor-positive breast cancer; however, 30–50% of patients receiving tamoxifen experience tumor relapse. CYP2D6, encoded ...

    Authors: Wouroud Ismail Al-khalil, Lana Al-Salhi, Sara Rijjal, Majd Aljamali and Lama A. Youssef
    Citation: BMC Cancer 2022 22:1067
  5. Pulmonary pleomorphic carcinoma (PPC) is a rare type of non-small cell lung cancer characterized by high malignancy and a poor prognosis. PPC is associated with a high frequency of postoperative relapse, and s...

    Authors: Kensuke Kojima, Saki Imai, Hironobu Samejima, Ayako Fujiwara, Toshiteru Tokunaga, Hyungeun Yoon and Kyoichi Okishio
    Citation: BMC Cancer 2022 22:1066
  6. Activated mutations in NOTCH1 are drivers of T-cell type acute lymphoblastic leukemia/lymphoma. The γ-secretase inhibitor (GSI), which suppresses the function of NOTCH1, is expected to be a molecular-targeted age...

    Authors: Shinsuke Suzuki, Sawako Hourai, Kimiharu Uozumi, Yuichirou Uchida, Makoto Yoshimitsu, Hachiman Miho, Naomichi Arima, Shin-ichi Ueno and Kenji Ishitsuka
    Citation: BMC Cancer 2022 22:1065
  7. C–C chemokine receptor type 7 (CCR7) participates in chemotactic and metastatic responses in various cancers, including in esophageal squamous cell carcinoma (ESCC). The microRNA (miRNA) let-7a suppresses migr...

    Authors: Masahiro Yura, Kazumasa Fukuda, Satoru Matsuda, Tomoyuki Irino, Rieko Nakamura, Hirofumi Kawakubo, Hiroya Takeuchi and Yuko Kitagawa
    Citation: BMC Cancer 2022 22:1064
  8. Although penile cancer (PC) is uncommon in developed countries, it is widespread in developing countries. The state of Maranhão (Northeast, Brazil) has the highest global incidence recorded for PC, and, despit...

    Authors: Antonio Augusto Lima Teixeira Júnior, Syomara Pereira da Costa Melo, Jaqueline Diniz Pinho, Thaís Bastos Moraes Sobrinho, Thalita Moura Silva Rocha, Denner Rodrigo Diniz Duarte, Liseana de Oliveira Barbosa, Wesliany Everton Duarte, Marta Regina de Castro Belfort, Kelly Gomes Duarte, Antonio Lima da Silva Neto, José de Ribamar Rodrigues Calixto, Lúcio Cristiano Paiva Paiva, Francisco Sérgio Moura Silva do Nascimento, Antonio Machado Alencar Junior, André Salim Khayat…
    Citation: BMC Cancer 2022 22:1063
  9. Current pre-operative Sentinel Lymph Node (SLN) mapping using dual tracing is associated with drawbacks (radiation exposure, logistic challenges). Superparamagnetic iron oxide (SPIO) is a non-inferior alternat...

    Authors: Loeki Aldenhoven, Caroline Frotscher, Rachelle Körver-Steeman, Milou H. Martens, Damir Kuburic, Alfred Janssen, Geerard L. Beets and James van Bastelaar
    Citation: BMC Cancer 2022 22:1062
  10. The purpose of this study was to compare the diagnostic value of serum oligosaccharide chain (G-test), alpha-fetoprotein (AFP) and aspartic aminotransferase to alanine aminotransferase ratios (AAR), both alone...

    Authors: Wentao Zhu, Pei Shi, An Liang, Ying Zhu, Jiwei Fu, Songsong Yuan and Xiaoping Wu
    Citation: BMC Cancer 2022 22:1061
  11. We investigated whether partner (spouse or intimate partner) engagement in colorectal cancer (CRC) surveillance is associated with patient receipt of surveillance.

    Authors: Christine M. Veenstra, Katrina R. Ellis, Paul Abrahamse, Kevin C. Ward, Arden M. Morris and Sarah T. Hawley
    Citation: BMC Cancer 2022 22:1060
  12. The distribution of lymphoma subtypes differs strikingly by geographic variations. However, there is limited information on this research in northern Iran. This study aims to evaluate the incidence, subtype, a...

    Authors: Javad Jalili, Amir Vahedi, Amin Danandehmehr, Parya Aynechi, Ali Esfahani, Yousef Roosta, Hooman Nateghian, Amirhosein Ghafouri Asbagh and Fateme Hajihoseinlou
    Citation: BMC Cancer 2022 22:1059
  13. It is crucial to determine feasibility of risk-stratified screening to facilitate successful implementation. We introduced risk-stratification (BC-Predict) into the NHS Breast Screening Programme (NHSBSP) at t...

    Authors: Rachel Hawkins, Lorna McWilliams, Fiona Ulph, D Gareth Evans and David P French
    Citation: BMC Cancer 2022 22:1058
  14. Despite today’s advances in the treatment of cancer, breast cancer-related mortality remains high, in part due to the lack of effective targeted therapies against breast tumor types that do not respond to stan...

    Authors: Carolina Di Benedetto, Justin Oh, Zainab Choudhery, Weiquan Shi, Gilmer Valdes and Paola Betancur
    Citation: BMC Cancer 2022 22:1056
  15. Increasing evidence suggests that cancer-derived extracellular vesicles (EVs) alter the phenotype and functions of fibroblasts and trigger the reprogramming of normal fibroblasts into cancer-associated fibrobl...

    Authors: Lilite Sadovska, Pawel Zayakin, Cristina Bajo-Santos, Edgars Endzeliņš, Jānis Auders, Laura Keiša, Juris Jansons, Vilnis Lietuvietis and Aija Linē
    Citation: BMC Cancer 2022 22:1055
  16. A majority of patients undergoing curative intent surgery for pancreatic ductal adenocarcinoma (PDAC) will unfortunately develop recurrent disease. Treatment outcomes for patients with metastatic disease remai...

    Authors: Laura Miotke, Christopher Nevala-Plagemann, Jian Ying, Vaia Florou, Benjamin Haaland and Ignacio Garrido-Laguna
    Citation: BMC Cancer 2022 22:1054
  17. As a negative co-stimulatory molecule of the B7 family, B7-H4 has recently attracted increased attention. However, the clinical value of B7-H4 in colorectal cancer (CRC) remains controversial and requires furt...

    Authors: Xiaotian Yan, Bo Hong, Jie Feng, Yuanqing Jin, Mengting Chen, Fugang Li and Yun Qian
    Citation: BMC Cancer 2022 22:1053
  18.  Screening recommendations for colorectal cancer (CRC) are mainly based on family history rather than lifestyle risk factors. We aimed to assess and compare risk factors for colorectal neoplasm (CRN) and evalu...

    Authors: Shuyuan Wang, Zhen Yuan, Yuqi Wang, Xuanzhu Zhao, Weifeng Gao, Hongzhou Li, Yuanshun Zhao, Zili Zhang, Shuiqing Liang, Zhaoce Liu, Qinghuai Zhang, Hong Ma, Xipeng Zhang, Wei Cui and Chunze Zhang
    Citation: BMC Cancer 2022 22:1051
  19. Uterine sarcomas are rare and aggressive gynaecologic malignancies, characterized by a relatively high recurrence rate and poor prognosis. The aim of this study was to investigate the clinicopathological featu...

    Authors: Fang Wang, Xinyue Dai, Huijun Chen, Xiaoli Hu and Yuanqiu Wang
    Citation: BMC Cancer 2022 22:1050
  20. Cholesterol and lipids play an important role in sustaining tumor growth and metastasis in a large variety of cancers. ANGPTL3 and PCSK9 modify circulating cholesterol levels, thus availability of lipids to pe...

    Authors: Emilie Wong Chong, France-Hélène Joncas, Nabil G. Seidah, Frédéric Calon, Caroline Diorio and Anne Gangloff
    Citation: BMC Cancer 2022 22:1049
  21. The combination of immune-checkpoint inhibitors with chemotherapy has become the standard of treatment for non-small cell lung cancer (NSCLC) patients. However, the association between therapeutic efficacy and...

    Authors: Kana Kurokawa, Yoichiro Mitsuishi, Naoko Shimada, Yuta Kawakami, Keita Miura, Taichi Miyawaki, Tetsuhiko Asao, Ryo Ko, Takehito Shukuya, Rina Shibayama, Shuko Nojiri and Kazuhisa Takahashi
    Citation: BMC Cancer 2022 22:1047
  22. Multiple mutation (MM) within a single gene has recently been reported as a mechanism involved in carcinogenesis. The present study investigated the clinical significance of MMs in hepatocellular carcinoma (HCC).

    Authors: Taisuke Imamura, Yukiyasu Okamura, Keiichi Ohshima, Katsuhiko Uesaka, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Katsuhisa Ohgi, Shimpei Otsuka, Sumiko Ohnami, Takeshi Nagashima, Keiichi Hatakeyama, Takashi Sugino, Kenichi Urakami, Yasuto Akiyama…
    Citation: BMC Cancer 2022 22:1046
  23. Prediction of patient survival from tumor molecular ‘-omics’ data is a key step toward personalized medicine. Cox models performed on RNA profiling datasets are popular for clinical outcome predictions. But th...

    Authors: Rémy Jardillier, Dzenis Koca, Florent Chatelain and Laurent Guyon
    Citation: BMC Cancer 2022 22:1045
  24. Pancreatic adenocarcinoma (PAAD) is a leading cause of cancer-related mortality in adults. Syndecan-4 (SDC4) is involved in cancer pathogenesis. Therefore, this study aimed to explore the expression and clinic...

    Authors: Yufei Zhu, Dijie Zheng, Linhan Lei, Kun Cai, Huahua Xie, Jian Zheng and Chao Yu
    Citation: BMC Cancer 2022 22:1042
  25. Adjuvant therapies such as radiation therapy, chemotherapy, and immunotherapy are usually given after cancer surgery to improve the survival of cancer patients. However, despite advances in several adjuvant th...

    Authors: Hye Won Kwak, So-Hee Hong, Hyo-Jung Park, Hyeong-Jun Park, Yoo-Jin Bang, Jae-Yong Kim, Yu-Sun Lee, Seo-Hyeon Bae, Hyunho Yoon and Jae-Hwan Nam
    Citation: BMC Cancer 2022 22:1041
  26. Overexpression of the EVI1 (ecotropic viral integration site 1) oncogene has recently been implicated as a prognostic factor in breast cancer (BC), particularly in triple-negative BC (TNBC). In this study we a...

    Authors: Jonas Leichsenring, Valentina Vladimirova, Christine Solbach, Thomas Karn, Beyhan Ataseven, Bruno Valentin Sinn, Jana Barinoff, Volkmar Müller, Jens-Uwe Blohmer, Christian Schem, Knut Engels, Frederik Marmé, Annette Fisseler-Eckhoff, Peter A. Fasching, Elmar Stickeler, Marion van Mackelenbergh…
    Citation: BMC Cancer 2022 22:1040
  27. Although evidence has revealed that miR-200a-3p is involved in the malignant progression of various tumors, the regulatory mechanism of miR-200a-3p in the development of cervical cancer (CC) cells with differe...

    Authors: Hong Chen, Lingling Gu, Min Zhang, Huifen Chen, Hong Liao, Xueping Cao, Lu Yu and Jun Zhang
    Citation: BMC Cancer 2022 22:1039
  28. The incidence of colorectal cancer (CRC) is considered to be the third-highest malignant tumor among all carcinomas. The alterations in cellular bioenergetics (metabolic reprogramming) are associated with seve...

    Authors: Jiaxin Liu, Yimin Li, Qing Xiao, Yuanyuan Li, Yuqian Peng, Yaqi Gan, Guang Shu, Hanxi Yi and Gang Yin
    Citation: BMC Cancer 2022 22:1038
  29. Fatty acid (FA) metabolism is considered the emerging cause of tumor development and metastasis, driving poor prognosis. Long non-coding RNAs (lncRNAs) are closely related to cancer progression and play import...

    Authors: Erbao Chen, Jing Yi, Jing Jiang, Zhilin Zou, Yuqian Mo, Qingqi Ren, Zewei Lin, Yi Lu, Jian Zhang and Jikui Liu
    Citation: BMC Cancer 2022 22:1037
  30. The global burden of hepatocellular carcinoma (HCC) is increasing, negatively impacting social health and economies. The discovery of novel and valuable biomarkers for the early diagnosis and therapeutic guida...

    Authors: Guozhi Wu, Yuan Yang, Rong Ye, Hanxun Yue, Huiyun Zhang, Taobi Huang, Min Liu, Ya Zheng, Yuping Wang, Yongning Zhou and Qinghong Guo
    Citation: BMC Cancer 2022 22:1036
  31. This study aimed to determine the effectiveness of liquid biopsy in detecting epidermal growth factor receptor (EGFR) mutations at diagnosis, disease progression, and intermediate stages.

    Authors: Hiroaki Fujii, Hideyuki Nagakura, Nobuaki Kobayashi, Sousuke Kubo, Katsushi Tanaka, Keisuke Watanabe, Nobuyuki Horita, Yu Hara, Masanori Nishikawa, Kenji Miura, Harumi Koizumi, Yu Ito, Motofumi Tsubakihara, Naoki Miyazawa, Makoto Kudo, Masaharu Shinkai…
    Citation: BMC Cancer 2022 22:1035
  32. This French nationwide NETSARC exhaustive prospective cohort aims to explore the impact of systematic re-excision (RE) as adjuvant care on overall survival (OS), local recurrence free survival (LRFS), and loca...

    Authors: Francois Gouin, Eberhard Stoeckle, Charles Honoré, Mickael Ropars, Mehrdad Jafari, Jean Camille Mattei, Alexandre Rochwerger, Sébastien Carrere, Denis Waast, Gwenaël Ferron, Jean-Christophe Machiavello, Philippe Anract, Frédéric Marchal, François Sirveaux, Oren Marco, Jérôme Guiramand…
    Citation: BMC Cancer 2022 22:1034
  33. Trastuzumab is an important targeted drug for HER2-positive gastric cancer. The treatment efficacy of a more cost-effective and accessible trastuzumab biosimilar, HLX02, was not well investigated, especially w...

    Authors: Jianye Liang, Wei Dai, Zhipeng Li, Xiangjing Liang, Mingjia Xiao, Chuanmiao Xie and Xinming Li
    Citation: BMC Cancer 2022 22:1033
  34. Multiple myeloma (MM) is the third most common hematologic malignancy with increasing importance due to improving treatment strategies and long-term outcomes in an aging population. This study aims to analyse ...

    Authors: Julia Fischer, Stefan Knop, Sophia Danhof, Hermann Einsele, Daniela Keller and Claudia Löffler
    Citation: BMC Cancer 2022 22:1032
  35. Both Response Evaluation Criteria in Solid Tumors (RECIST) and tumor regression grade (TRG) play key roles in evaluating tumor response. We analyzed the consistency of TRG and RECIST 1.1 for gastric cancer (GC...

    Authors: Ming-Yu Lai, Shi-Yang Kang, Yu-Ting Sun, Ting-Ting Quan, Shi-Xun Lu, Cai-Yun He, Zhi-Wei Zhou, Li-Qiong Yang, Hui-Yan Luo, Feng-Hua Wang, Yu-Hong Li, Rui-Hua Xu, Wen-Long Guan and Miao-Zhen Qiu
    Citation: BMC Cancer 2022 22:1031
  36. Emerging proof shows that abnormal lipometabolism affects invasion, metastasis, stemness and tumor microenvironment in carcinoma cells. However, molecular markers related to lipometabolism have not been furthe...

    Authors: Lei Zhang, Risheng She, Jianlin Zhu, Jin Lu, Yuan Gao, Wenhua Song, Songwang Cai and Lu Wang
    Citation: BMC Cancer 2022 22:1030
  37. Osteosarcoma (OS) is one of the malignant bone tumors with strong aggressiveness and poor prognosis. Leucine-rich repeats and immunoglobulin-like domains2 (LRIG2) is closely associated with the poor prognosis ...

    Authors: Zhi-Qiang Li, Wei-Jie Liao, Bo-Lin Sun, Zhi-Wen Luo, Nan-Shan Zhong, Jia-Bao Wu, Zhi-Li Liu and Jia-Ming Liu
    Citation: BMC Cancer 2022 22:1029
  38. S-1 adjuvant chemotherapy is the standard treatment in Asia for resectable pancreatic ductal adenocarcinoma. The relative dose intensity of adjuvant chemotherapy influences survival in pancreatic cancer but do...

    Authors: Kazuki Kobayashi, Takahiro Einama, Yasuhiro Takihata, Naoto Yonamine, Ibuki Fujinuma, Takazumi Tsunenari, Keita Kouzu, Akiko Nakazawa, Toshimitsu Iwasaki, Hideki Ueno and Yoji Kishi
    Citation: BMC Cancer 2022 22:1028
  39. The protein Talin1 encoded by the TLN1 gene is a focal adhesion-related protein that binds to various cytoskeletal proteins and plays an important role in cell adhesion and movement. Recent studies have shown tha...

    Authors: Di Cui, Xilong Cui, Xiaoliang Xu, Wenjing Zhang, Yu Yu, Yingxin Gao, Chuanzhong Mei and Weiwei Zheng
    Citation: BMC Cancer 2022 22:1027
  40. Alternative polyadenylation (APA) is emerging as a crucial regulatory mechanism in bladder cancer (BC), while it remains elusive whether APA influences the tumor immune microenvironment (TIME) in BC. We identi...

    Authors: Ming Xiong, Wencheng Li, Longwang Wang, Liang Chen, Zhaohui Chen, Chengcheng Wei, Futian Zhang, Jiawei Chen, Gallina Kazobinka, Jun Zhao and Teng Hou
    Citation: BMC Cancer 2022 22:1026
  41. The biguanide metformin has been shown to not only reduce circulating glucose levels but also suppress in vitro and in vivo growth of prostate cancer. However, the mechanisms underlying the anti-tumor effects ...

    Authors: Emuejevoke Olokpa, Sammed N. Mandape, Siddharth Pratap and La Monica V. Stewart
    Citation: BMC Cancer 2022 22:1025
  42. Telomere dysfunction results in aneuploidy, and ongoing chromosomal abnormalities. The three-dimensional (3D) nuclear organization of telomeres allows for a distinction between normal and tumor cells. On the o...

    Authors: Fábio Morato de Oliveira, Valderez Ravaglio Jamur, Lismeri Wuicik Merfort, Aline Rangel Pozzo and Sabine Mai
    Citation: BMC Cancer 2022 22:1024
  43. Cancer patients have an increased risk of developing venous thromboembolism, with up to 30% dying within a month of their development. Some cancer cells are known to induce platelet aggregation, and this inter...

    Authors: Niamh McNamee, Laura Rodriguez de la Fuente, Maria Jose Santos-Martinez and Lorraine O’Driscoll
    Citation: BMC Cancer 2022 22:1023
  44. This study aims to systematically validate the performance of surrogate endpoints in phase II and III clinical trials for NSCLC patients under various trial settings.

    Authors: Tiantian Hua, Yuan Gao, Ruyang Zhang, Yongyue Wei and Feng Chen
    Citation: BMC Cancer 2022 22:1022
  45. Salivary gland carcinomas (SGC) are extremely rare malignancies with only limited treatment options for the metastatic phase of the disease. Treatment with anti-CD47 antibodies could represent a potent therapy...

    Authors: Michal Votava, Robin Bartolini, Linda Capkova, Jitka Smetanova, Vachtenheim Jiri Jr, Martin Kuchar, David Kalfert, Jan Plzak, Jirina Bartunkova and Zuzana Strizova
    Citation: BMC Cancer 2022 22:1021

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