The Zc3h8 gene encodes a protein with three zinc finger motifs in the C-terminal region. The protein has been identified as a component of the Little Elongation Complex, involved in transcription of small nuclear...
Authors: John A. Schmidt, Keith G. Danielson, Emily R. Duffner, Sara G. Radecki, Gerard T. Walker, Amber Shelton, Tianjiao Wang and Janice E. Knepper
The impact of sarcopenia on the prognosis of patients with hepatocellular carcinoma (HCC) who receive transcatheter intra-arterial therapies, including transcatheter arterial chemoembolization and transcathete...
Cancer-related fatigue (CRF) is a common and distressing symptom of cancer and/or cancer treatment that persists for years after treatment completion in approximately one third of cancer survivors. Exercise is...
Authors: Rosie Twomey, Tristan Martin, John Temesi, S. Nicole Culos-Reed and Guillaume Y. Millet
At time of diagnosis, less than 10% of patients with pancreatic adenocarcinomas (PDAC) are considered to be immediately operable (i.e. resectable). Considering their poor overall survival (OS), only tumours wi...
Authors: Lilian Schwarz, Dewi Vernerey, Jean-Baptiste Bachet, Jean-Jacques Tuech, Fabienne Portales, Pierre Michel and Antonio Sa Cunha
Controversy exists for the use of Ki67 protein expression as a predictive marker to select patients who do or do not derive benefit from adjuvant endocrine therapy. Whether other proliferation markers, like Cy...
Authors: Karin Beelen, Mark Opdam, Tesa Severson, Rutger Koornstra, Andrew Vincent, Jelle Wesseling, Joyce Sanders, Jan Vermorken, Paul van Diest and Sabine Linn
With the development of sequencing technologies, there may be some disputes on sequencing analysis. The aim of this study was to investigate different allele frequency thresholds of mutations in targeted genes...
Authors: Jie Ma, Yong Fu, Yao-yao Tu, Ying Liu, Yi-ran Tan, Wu-tong Ju, Curtis R. Pickering, Jeffrey N. Myers, Zhi-yuan Zhang and Lai-ping Zhong
Maximum (MIP) and average intensity projection (AIP) CTs allow rapid definition of internal target volumes in a 4D-CT. The purpose of this study was to assess the accuracy of these techniques in a large patien...
Authors: Kai Joachim Borm, Markus Oechsner, Moritz Wiegandt, Andreas Hofmeister, Stephanie E. Combs and Marciana Nona Duma
This meta-analysis was performed to explore the impact of minimal residual disease (MRD) prior to transplantation on the prognosis for patients with acute lymphoblastic leukemia (ALL).
Authors: Zhenglei Shen, Xuezhong Gu, Wenwen Mao, Liefen Yin, Ling Yang, Zhe Zhang, Kunmei Liu, Lilan Wang and Yunchao Huang
Disulfiram (DS), an antialcoholism medicine, demonstrated strong anticancer activity in the laboratory but did not show promising results in clinical trials. The anticancer activity of DS is copper dependent. ...
Authors: Kate Butcher, Vinodh Kannappan, Rajagopal Sharada Kilari, Mark R. Morris, Christopher McConville, Angel L. Armesilla and Weiguang Wang
Lung cancer is the leading cause of cancer mortality worldwide. Early diagnosis and treatment is a key factor in reducing mortality and improving patient outcomes. To achieve this, it is important to understan...
Authors: Danielle Mazza, Xiaoping Lin, Fiona M. Walter, Jane M. Young, David J. Barnes, Paul Mitchell, Bianca Brijnath, Andrew Martin and Jon D. Emery
Colorectal cancer (CRC) patients with metastatic disease can become cured if neoadjuvant treatment can enable a resection. The search for predictive biomarkers is often performed on primary tumours tissue. In ...
Authors: M. B. Mogensen, M. Rossing, O. Østrup, P. N. Larsen, P. J. Heiberg Engel, L. N. Jørgensen, E. V. Hogdall, J. Eriksen, P. Ibsen, P. Jess, M. Grauslund, H. J. Nielsen, F. C. Nielsen, B. Vainer and K. Osterlind
This prospective multicentre-study aimed to analyze return to work (RTW) among prostate cancer survivors 12 months after having attended a cancer rehabilitation program and to identify risk factors for no and ...
Authors: Anneke Ullrich, Hilke Maria Rath, Ullrich Otto, Christa Kerschgens, Martin Raida, Christa Hagen-Aukamp and Corinna Bergelt
We previously observed that T-bet+ tumor-infiltrating T lymphocytes (T-bet+ TILs) in primary breast tumors were associated with adverse clinicopathological features, yet favorable clinical outcome. We identifi...
Authors: Minji Lee, Farnoosh Tayyari, Dushanthi Pinnaduwage, Jane Bayani, John M. S. Bartlett, Anna Marie Mulligan, Shelley B. Bull and Irene L. Andrulis
After publication of the original article [1], the authors found that Fig. 3 contained an incorrect version of Fig. 3c. This does not affect the Figure legend, results and conclusions of the article.
Authors: Jessica A. Gibbons, Jagat R. Kanwar and Rupinder K. Kanwar
Anaplastic thyroid cancer (ATC) is one of the most aggressive of all solid tumors for which no effective therapies are currently available. Oncolytic Newcastle disease virus (NDV) has shown the potential to in...
Authors: Ke Jiang, Cuiping Song, Lingkai Kong, Lulu Hu, Guibin Lin, Tian Ye, Gang Yao, Yupeng Wang, Haibo Chen, Wei Cheng, Martin P. Barr, Quentin Liu, Guirong Zhang, Chan Ding and Songshu Meng
Despite the significant, empirically supported benefits of physical activity, the majority of breast cancer survivors do not meet recommended guidelines for physical activity. A variety of effective strategies...
Authors: Chad D. Rethorst, Heidi A. Hamann, Thomas J. Carmody, Kendall J. Sharp, Keith E. Argenbright, Barbara B. Haley, Celette Sugg Skinner and Madhukar H. Trivedi
Approximately one third of the colorectal cancer survivors (CRCS) experience high levels of psychological distress. Common concerns experienced by CRCS include distress related to physical problems, anxiety, f...
Authors: L. Leermakers, S. Döking, B. Thewes, A. M. J. Braamse, M. F. M. Gielissen, J. H. W. de Wilt, E. H. Collette, J. Dekker and J. B. Prins
Cervical cancer is the most common cancer among women in Kenya. However, only 3% of women are routinely screened. This study aimed to assess women’s knowledge and attitudes towards cervical cancer and cervical...
Authors: Murithi Gatumo, Susan Gacheri, Abdul-Rauf Sayed and Andrew Scheibe
In the group of elderly patients (≥70 years) with metastatic pancreatic ductal adenocarcinoma (mPDAC), it is not known who benefits from intensive 1st line nab-paclitaxel/gemcitabine (nab-p/gem) combination ch...
Authors: Johannes Betge, Jing Chi-Kern, Nadine Schulte, Sebastian Belle, Tobias Gutting, Elke Burgermeister, Ralf Jesenofsky, Martin Maenz, Ulrich Wedding, Matthias P. Ebert and Nicolai Haertel
The receptor CXCR4 and its ligand CXCL12 play crucial roles in breast cancer. Despite the fact that the spontaneous feline mammary carcinoma (FMC) is considered a suitable model for breast cancer studies, the ...
Authors: Cláudia S. Marques, Ana Rita Santos, Andreia Gameiro, Jorge Correia and Fernando Ferreira
Previous studies have reported radiotherapy interruption (RTI) is associated with poor local control in two-dimensional radiotherapy (2DRT) era. However, it remains unclear whether RTI still affects local cont...
Authors: Ji-Jin Yao, Ya-Nan Jin, Si-Yang Wang, Fan Zhang, Guan-Qun Zhou, Wang-Jian Zhang, Zhi-Bin, Cheng, Jun Ma, Zhen-Yu Qi and Ying Sun
Aberrant AKT activation is prevalent across human cancer lineages, providing an important therapeutic target. AKT comprises three isoforms that mediate critical non-redundant, even opposing functions in cancer...
Authors: Jue Wang, Wei Zhao, Huifang Guo, Yong Fang, Sarah Elizabeth Stockman, Shanshan Bai, Patrick Kwok-Shing Ng, Yang Li, Qinghua Yu, Yiling Lu, Kang Jin Jeong, Xiaohua Chen, Meng Gao, Jiyong Liang, Wentao Li, Xingsong Tian…
HER2 positive (HER2+) breast cancers involve chromosomal structural alterations that act as oncogenic driver events.
Authors: George Vasmatzis, Xue Wang, James B. Smadbeck, Stephen J. Murphy, Katherine B. Geiersbach, Sarah H. Johnson, Athanasios G. Gaitatzes, Yan W. Asmann, Farhad Kosari, Mitesh J. Borad, Daniel J. Serie, Sarah A. McLaughlin, Jennifer M. Kachergus, Brian M. Necela and E. Aubrey Thompson
Bone and soft tissue masses of the foot and ankle are not particularly rare but true neoplasia has to be strictly differentiated from pseudotumorous lesions. Diagnosis is often delayed as diagnostic errors are...
Authors: Andreas Toepfer, Norbert Harrasser, Maximiliane Recker, Ulrich Lenze, Florian Pohlig, Ludger Gerdesmeyer and Rüdiger von Eisenhart-Rothe
The development of both chronic obstructive pulmonary disease (COPD) and lung cancer (LC) is influenced by smoking related chronic pulmonary inflammation caused by an excessive innate immune response to smoke ...
Authors: Janna Berg, Ann Rita Halvorsen, May-Bente Bengtson, Kristin A. Taskén, Gunhild M. Mælandsmo, Arne Yndestad, Bente Halvorsen, Odd Terje Brustugun, Pål Aukrust, Thor Ueland and Åslaug Helland
The incidence of recurrent laryngeal nerve (RLN) injury has increased due to RLN lymph node dissection. The aim of this study was to evaluate the ability of intraoperative ultrasonography (IU) to detect RLN no...
Authors: Jianwei Wang, Min Liu, Jingxian Shen, Haichao Ouyang, Xiuying Xie, Ting Lin, Anhua Li and Hong Yang
MLKL is the most important executor of necroptosis pathway. Recent studies have demonstrated that MLKL could serve as a potential prognostic biomarker for cancer patients. However, most studies reported so far...
Authors: Binwu Hu, Deyao Shi, Xiao Lv, Songfeng Chen, Qin Huang, Mao Xie and Zengwu Shao
Early diagnosis of head and neck squamous cell carcinoma (HNSCCs) is an appealing way to increase survival rates in these patients as well as to improve quality of life post-surgery. Angiogenesis is a hallmark...
Authors: L. van der Merwe, Y. Wan, H. J. Cheong, C. Perry and C. Punyadeera
Quality of cancer care (QoCC) has become an important item for providers, regulators and purchasers of care worldwide. Aim of this study is to present the results of some evidence-based quality indicators (QI)...
Authors: Laura Ortelli, Alessandra Spitale, Luca Mazzucchelli and Andrea Bordoni
Targeted therapy has always been the focus in developing therapeutic approaches in cancer, especially in the treatment of acute myeloid leukemia (AML). A new small molecular inhibitor, JQ1, targeting BRD4, whi...
Authors: Yafeng Zhou, Jianbiao Zhou, Xiao Lu, Tuan-Zea Tan and Wee-Joo Chng
Adjuvant endocrine therapy (AET) significantly decreases the risk of breast cancer recurrence and mortality. Notwithstanding the demonstrated efficacy of AET, 31–73% of breast cancer survivors do not persist w...
Authors: Leah K. Lambert, Lynda G. Balneaves, A. Fuchsia Howard, Stephen K. Chia and Carolyn C. Gotay
A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy options are limited in salvage therapy. This is the first study to evaluate a bendamu...
Authors: Therasa Kim, He Yun Choi, Hyun-Seo Lee, Sung-Hoon Jung, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee, Hee-Doo Yoo and Deok-Hwan Yang
The phenomenon of chemotherapy-resistant cancers has necessitated the development of new therapeutics as well as the identification of specific prognostic markers to predict the response to novel drugs. Primar...
Authors: Anna A. Nushtaeva, Grigory A. Stepanov, Dmitry V. Semenov, Evgeny S. Juravlev, Evgenia A. Balahonova, Alexey V. Gerasimov, Sergey V. Sidorov, Eugeniy I. Savelyev, Elena V. Kuligina, Vladimir A. Richter and Olga A. Koval
Medication adherence refers to whether a patient takes medication according to the frequency prescribed, or continues to take a prescribed medication. Inadequate adherence to medication may cause alterations i...
Authors: Yunxin He, Eng Hooi Tan, Andrea Li Ann Wong, Chuan Chien Tan, Patrick Wong, Soo Chin Lee and Bee Choo Tai
Telomerase activity is required for both initiation and maintenance of tumorigenesis and over 90% cancers overexpress telomerase. Therefore, telomerase targeting has emerged as a potential strategy for cancer ...
Authors: Peter Solomon, Yuying Dong, Shaillay Dogra and Romi Gupta
Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metas...
Authors: Ashleigh C. McEvoy, Lydia Warburton, Zeyad Al-Ogaili, Liesl Celliers, Leslie Calapre, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Melanie Ziman and Elin S. Gray
Multiple myeloma (MM) patients with t(14;20) have a poor prognosis and their outcome has not improved following the introduction of bortezomib (Bzb). The mechanism underlying the resistance to proteasome inhib...
Authors: Ya-Wei Qiang, Shiqiao Ye, Yuhua Huang, Yu Chen, Frits Van Rhee, Joshua Epstein, Brian A. Walker, Gareth J. Morgan and Faith E. Davies
Infiltration into lymphatic vessels is a critical step in breast cancer metastasis. Lymphatics undergo changes that facilitate metastasis as a result of activation of the cells lining lymphatic vessels, lympha...
Authors: Alexandra R. Harris, Matthew J. Perez and Jennifer M. Munson
Interleukin-2 (IL-2) is an important immunotherapy cytokine for various diseases including cancer. Some studies reported the efficacy and safety on cisplatin combined with IL-2 versus cisplatin alone for treat...
Authors: Liping Han, Qiufang Jiang, Wei Yao, Tian Fu and Qingdi Zeng
The theory of field effect suggests that the tumor-adjacent area, besides histopathologically normal, undergoes genetic and epigenetic changes that can eventually affect epithelial homeostasis, predisposing th...
Authors: Camile B. Lopes, Leandro L. Magalhães, Carolina R. Teófilo, Ana Paula N. N. Alves, Raquel C. Montenegro, Massimo Negrini and Ândrea Ribeiro-dos-Santos
Epithelial-to-mesenchymal transition (EMT) is one mechanism of carcinoma migration, while complex tumour migration or bulk migration is another - best demontrated by tumour cells invading blood vessels.
Authors: Martin Zacharias, Luka Brcic, Sylvia Eidenhammer and Helmut Popper
Approximately 900 children/adolescents are treated with radiotherapy (RT) every year in France. However, among the 80% of survivors, the cumulative incidence of long-term morbidity – including second malignanc...
Authors: Valérie Bernier-chastagner, Liza Hettal, Véronique Gillon, Laurinda Fernandes, Cécile Huin-schohn, Marion Vazel, Priscillia Tosti, Julia Salleron, Aurélie François, Elise Cérimèle, Sandrine Perreira, Didier Peiffert, Pascal Chastagner and Guillaume Vogin
High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggest...
Authors: Christopher Platais, Raghu Radhakrishnan, Sven Niklander Ebensberger, Richard Morgan, Daniel W. Lambert and Keith D. Hunter
LIM and SH3 protein 1 (LASP1) is upregulated in several types of human cancer and implicated in cancer progression. However, the expression and intrinsic function of LASP1 in glioblastoma (GBM) remains unclear.
Authors: Chuanhong Zhong, Yitian Chen, Bei Tao, Lilei Peng, Tangming Peng, Xiaobo Yang, Xiangguo Xia and Ligang Chen
People aged 40–60 years with a family history (FH) of colorectal cancer (CRC) in 1st degree relatives (FDRs) have a 2- to 4-fold increased risk of CRC compared to the average risk population. Therefore, expert...
Authors: Kaja Tikk, Korbinian Weigl, Michael Hoffmeister, Svitlana Igel, Matthias Schwab, Jochen Hampe, Stefanie J. Klug, Ulrich Mansmann, Frank Kolligs and Hermann Brenner
Trans-arterial radio-embolization (TARE) is an emerging treatment for the management of hepatocellular carcinoma (HCC). TARE may compete with systemic chemotherapy, sorafenib, in intermediate stage patients wi...
Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O
Authors: Jeon Hwang-Bo, Mun Gyeong Bae, Jong-Hwa Park and In Sik Chung
Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the a...
Authors: Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, Jeong Su Oh and Jae-Sung Kim
Usually misdiagnosed, Inflammatory Breast Cancer (IBC) is the most aggressive form of non-metastatic breast cancer. This orphan disease is more frequent in North Africa. Despite intensive treatment, the surviv...
Authors: Meriem Slaoui, Abdou Azaque Zoure, Fatima Zahra Mouh, Youssef Bensouda, Mohammed El Mzibri, Youssef Bakri and Mariam Amrani
