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  1. Lymphovascular invasion (LVI) is a crucial predictor of lymph node metastasis (LNM). However, few studies have investigated the LVI positivity rate and its clinical significance in pT1b esophageal squamous cel...

    Authors: Linxiu Liu, Hua Lin, Guihua Shen, Yong Liu, Xiumin Qin, Yanling Yuan, Bingzhi Wang and Liyan Xue
    Citation: BMC Cancer 2023 23:370
    Content type: Research Published on:

  2. Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC). BRCA1 alterations can lead to impaired homologous recombination rep...

    Authors: Nicola Bassi, Henrikke Nilsen Hovland, Kashif Rasheed, Elisabeth Jarhelle, Nikara Pedersen, Eunice Kabanyana Mchaina, Sara Marie Engelsvold Bakkan, Nina Iversen, Hildegunn Høberg-Vetti, Bjørn Ivar Haukanes, Per Morten Knappskog, Ingvild Aukrust, Elisabet Ognedal and Marijke Van Ghelue
    Citation: BMC Cancer 2023 23:368
    Content type: Research Published on:

  3. The scavenger receptor CD36 was reported to be highly expressed on tumor-infiltrating CD8+ T cells, but the clinical role remains obscure. This study aims to explore the infiltration and clinical value of CD36+CD...

    Authors: Yong-Qiang Ao, Jian Gao, Ling-Xian Zhang, Jie Deng, Shuai Wang, Miao Lin, Hai-Kun Wang, Jian-Yong Ding and Jia-Hao Jiang
    Citation: BMC Cancer 2023 23:367
    Content type: Research Published on:

  5. In this study, we aimed to investigate the predictive efficacy of magnetic resonance imaging (MRI) radiomics features at different time points of neoadjuvant therapy for rectal cancer in patients with patholog...

    Authors: Jiaxuan Peng, Wei Wang, Hui Jin, Xue Qin, Jie Hou, Zhang Yang and Zhenyu Shu
    Citation: BMC Cancer 2023 23:365
    Content type: Research Published on:

  6. Homo sapiens chromosome 2 clone RP11-339H12 (AC010883.5) is a dysregulated long non-coding RNA (lncRNA) that has never been investigated in cervical cancer (CC). Thus, the potential function and molecular mechani...

    Authors: Qiyu Gan, Xia Huang, Wenrong Zhao, Hui Liu, Yan Xu, Xiaohua Zhang, Jingxin Cheng and Rui Chen
    Citation: BMC Cancer 2023 23:364
    Content type: Research Published on:

  7. Thyroid cancer is the most frequent malignancy of the endocrine system, of which papillary thyroid cancer (PTC) is the predominant form with a rapid increasing incidence worldwide. Rearranged during transfection ...

    Authors: Mengke Chen, Junyu Xue, Ye Sang, Wenting Jiang, Weiman He, Shubin Hong, Weiming Lv, Haipeng Xiao and Rengyun Liu
    Citation: BMC Cancer 2023 23:363
    Content type: Research Published on:

  8. Isolated local failure (ILF) can occur in patients who initially receive definitive radiation therapy for prostate cancer. Salvage therapy for ILF includes high dose rate (HDR) brachytherapy. Prostate Specific...

    Authors: Lucas C. Mendez, Aneesh Dhar, David Laidley, Madeleine Moussa, Jose A. Gomez, Joseph Chin, T-Y Lee, Jonathan D. Thiessen, Douglas Hoover, Kathleen Surrey, Joelle Helou, Vikram Velker, Rohann J. Correa, David D’Souza, Jane Bayani and Glenn Bauman
    Citation: BMC Cancer 2023 23:362
    Content type: Study Protocol Published on:

  9. Severe lymphedema presents a challenge in terms of treatment due to the significant formation of scar tissue that accompanies it. The aim of this study was to identify intraoperative and preoperative risk fact...

    Authors: Xiaozhen Liu, Kewang Sun, Hongjian Yang, Lingli Xia, Kefeng Lu, Xuli Meng and Yongfeng Li
    Citation: BMC Cancer 2023 23:361
    Content type: Research Published on:

  10. Over the past decade, there has been increasing availability of novel therapeutics with improved tolerability and efficacy for advanced non-small cell lung cancer (NSCLC). The study goals were: to compare the ...

    Authors: Bonnie Leung, Aria Shokoohi, Zamzam Al-Hashami, Sara Moore, Alexandra Pender, Selina K. Wong, Ying Wang, Jonn Wu and Cheryl Ho
    Citation: BMC Cancer 2023 23:360
    Content type: Research Published on:

  12. Positron emission tomography and computed tomography (PET-CT) is currently recommended in evaluating the treatment response after (chemo)radiotherapy ([C]RT). In the larynx, post-treatment changes and physiolo...

    Authors: Heli J. Sistonen, Taru Ilmarinen, Timo Atula, Katri Aro, Jukka Schildt and Antti Markkola
    Citation: BMC Cancer 2023 23:358
    Content type: Research Published on:

  13. Polypharmacy is very common in older cancer patients and these patients are particularly vulnerable to drug-drug interactions and adverse drug reactions because they often receive chemotherapy and symptom-reli...

    Authors: Ben Schöttker, Li-Ju Chen, Reiner Caspari and Hermann Brenner
    Citation: BMC Cancer 2023 23:357
    Content type: Study Protocol Published on:

  14. Colorectal cancer (CRC) is the third most prevalent cancer in the world, yet the sensitivity and specificity of biomarkers for CRC diagnosis are insufficient. In the present study, we performed a protein micro...

    Authors: Takahiro Arasawa, Takaki Hiwasa, Akiko Kagaya, Tetsuro Maruyama, Masaya Uesato, Masayuki Kano, Sohei Kobayashi, Hirotaka Takizawa, Katsuro Iwase, Fumio Nomura, Kazuyuki Matsushita and Hisahiro Matsubara
    Citation: BMC Cancer 2023 23:356
    Content type: Research Published on:

  15. Bladder cancer (BC) is one of the most common malignant diseases and the most common causes of cancer death worldwide. Immunotherapy has opened new avenues for precision treatment of bladder tumours, and immun...

    Authors: Pengyu Hui, Feng Ni, Liang Zheng, Lei Jia and Zhe Wang
    Citation: BMC Cancer 2023 23:355
    Content type: Research Published on:

  16. Oral mucositis (OM) is one of the main problems in almost all patients undergoing head and neck radiotherapy (RT). Owning to the antioxidant and anti-inflammatory properties of curcumin, the effect of both ora...

    Authors: Vahid Ramezani, Shiva Ghadirian, Masoud Shabani, Mohammad Ali Boroumand, Reza Daneshvar and Fatemeh Saghafi
    Citation: BMC Cancer 2023 23:354
    Content type: Research Published on:

  18. KRAS mutations occur frequently in advanced non-small cell lung cancer (aNSCLC); the G12C mutation is the most prevalent. Alterations in STK11 or KEAP1 commonly co-occur with KRAS mutations in aNSCLC. Using real...

    Authors: Cristina Julian, Navdeep Pal, Anda Gershon, Marie Evangelista, Hans Purkey, Peter Lambert, Zhen Shi and Qing Zhang
    Citation: BMC Cancer 2023 23:352
    Content type: Research Published on:

  19. Pancreaticoduodenectomy (PD) is a complex and traumatic abdominal surgery with a high risk of postoperative complications. Nutritional support, including immunonutrition (IMN) with added glutamine, arginine, a...

    Authors: Yinyin Fan, Nianxing Li, Jing Zhang, Qiaomei Fu, Yudong Qiu and Yan Chen
    Citation: BMC Cancer 2023 23:351
    Content type: Research Published on:

  20. There is substantial heterogeneity in symptom management provided to pediatric patients with cancer. The primary objective was to describe the adaptation process and specific adaptation decisions related to sy...

    Authors: Emily Vettese, Farha Sherani, Allison A. King, Lolie Yu, Catherine Aftandilian, Christina Baggott, Vibhuti Agarwal, Ramamoorthy Nagasubramanian, Kara M. Kelly, David R. Freyer, Etan Orgel, Scott M. Bradfield, Wade Kyono, Michael Roth, Lisa M. Klesges, Melissa Beauchemin…
    Citation: BMC Cancer 2023 23:350
    Content type: Research Published on:

  21. As both life expectancy and cancer survival improve, the incidence of multiple primary cancer has augmented and is expected to further increase. This study describes for the first time the epidemiology of mult...

    Authors: Gilles Macq, Geert Silversmit, Freija Verdoodt and Liesbet Van Eycken
    Citation: BMC Cancer 2023 23:349
    Content type: Research Published on:

  22. The addition of qualitative methodology to randomised controlled trials evaluating complex interventions allows better understanding of contextualised factors and their potential influence on trial delivery an...

    Authors: Orla McCourt, Abigail Fisher, Joanne Land, Gita Ramdharry, Anna L Roberts, Georgios Bekris and Kwee Yong
    Citation: BMC Cancer 2023 23:348
    Content type: Research Published on:

  23. Colorectal cancer (CRC) is the fourth and third most common cancer in Iran and the world, respectively. Carbohydrates can lead to the proliferation of cancer cells, including CRC. The current study aimed to in...

    Authors: Masoud Amini Kahrizsangi, Zohreh Ebrahimi, Zainab Shateri, Fatemeh Mansouri, Ali Zangene, Milad Rajabzadeh-Dehkordi, Mehran Nouri and Bahram Rashidkhani
    Citation: BMC Cancer 2023 23:347
    Content type: Research Published on:

  24. Newcastle disease virus (NDV) is an oncolytic virus that can inhibit cancer cell proliferation and kill cancer cells. The NDV nonstructural V protein can regulate viral replication; however, whether the V prot...

    Authors: Zhili Chu, Sihui Yang, Qianru Li, Jianing Shang, Zilong Ren and Feng Ren
    Citation: BMC Cancer 2023 23:346
    Content type: Research Published on:

  25. Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment landscape of relapsed/refractory multiple myeloma (RRMM), leading to unprecedented responses in this patient population. Idecabta...

    Authors: Dilara Akhoundova Sanoyan, Katja Seipel, Ulrike Bacher, Marie-Noelle Kronig, Naomi Porret, Gertrud Wiedemann, Michael Daskalakis and Thomas Pabst
    Citation: BMC Cancer 2023 23:345
    Content type: Research Published on:

  26. Despite standard treatments including chemoradiotherapy with temozolomide (TMZ) (STUPP protocol), the prognosis of glioblastoma patients remains poor. AGuIX nanoparticles have a high radiosensitizing potential...

    Authors: Emilie Thivat, Mélanie Casile, Juliette Moreau, Ioana Molnar, Sandrine Dufort, Khalide Seddik, Géraldine Le Duc, Olivier De Beaumont, Markus Loeffler, Xavier Durando and Julian Biau
    Citation: BMC Cancer 2023 23:344
    Content type: Study Protocol Published on:

  27. Cells in every epithelium can be roughly divided in three compartments: stem cell (SC) compartment, transient amplifying cell (TA) compartment and terminally differentiated (TD) compartment. Maturation of stem...

    Authors: Benjamin Benzon, Sandra Marijan, Matij Pervan and Vedrana Čikeš Čulić
    Citation: BMC Cancer 2023 23:343
    Content type: Research Published on:

  28. This study aimed to investigate the effect of preoperative albumin-to-globulin ratio (AGR) on overall survival (OS) and health-related quality of life in patients with esophageal cell squamous carcinoma (ESCC).

    Authors: Juwei Zhang, Zheng Lin, Jinsong Zhou, Yue Huang, Siting Chen, Yuan Deng, Minglian Qiu, Yuanmei Chen and Zhijian Hu
    Citation: BMC Cancer 2023 23:342
    Content type: Research Published on:

  30. Preoperative evaluation of axillary lymph node (ALN) status is an essential part of deciding the appropriate treatment. According to ACOSOG Z0011 trials, the new goal of the ALN status evaluation is tumor burd...

    Authors: Yu Chen, Yongwei Xie, Bo Li, Hua Shao, Ziyue Na, Qiucheng Wang and Hui Jing
    Citation: BMC Cancer 2023 23:340
    Content type: Research Published on:

  31. Inherited mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 (BRCA1/2) confer high risks of breast and ovarian cancer. Because the contribution of BRCA1/2 germline mutations to BC in the Northeas...

    Authors: Rahma Melki, Marouane Melloul, Souria Aissaoui, Tijani EL Harroudi and Noureddine Boukhatem
    Citation: BMC Cancer 2023 23:339
    Content type: Research Published on:

  32. Carcinoid heart disease is a rare disease which develops in patients with functional neuroendocrine tumors in an advanced tumor state. Patients diagnosed with carcinoid heart disease have a poor longtime progn...

    Authors: Eva Grundmann, Alessandra Curioni-Fontecedro, Emanuel Christ and Alexander R. Siebenhüner
    Citation: BMC Cancer 2023 23:338
    Content type: Research Published on:

  33. The utilization of stereotactic body radiation therapy (SBRT) is increasing for primary and secondary lung neoplasms. Despite encouraging results, SBRT is associated with an increased risk of osteoradionecrosi...

    Authors: Michael P. Carducci, Baskaran Sundaram, Benjamin A. Greenberger, Maria Werner-Wasik and Gregory C. Kane
    Citation: BMC Cancer 2023 23:337
    Content type: Research Published on:

  34. Colorectal cancer (CRC) is a common disease threatening human lives worldwide, and vitamin D receptor (VDR) contributes protective roles in this disease. However, the molecular mechanisms underlying VDR protec...

    Authors: Jie Yu, Qi Sun, Yi Hui, Jinping Xu, Pancheng Shi, Yu Chen and Yunzhao Chen
    Citation: BMC Cancer 2023 23:336
    Content type: Research Published on:

  35. Peroxisome proliferator activated receptors (PPARs) are a nuclear hormone receptors superfamily that is closely related to fatty acid (FA) metabolism and tumor progression. Solute carrier family 27 member 2 (SLC2...

    Authors: Kun Shang, Nina Ma, Juanjuan Che, Huihui Li, Jiexuan Hu, Haolin Sun and Bangwei Cao
    Citation: BMC Cancer 2023 23:335
    Content type: Research Published on:

  36. Periampullary cancer is a term for cancers arising in or in close proximity to the pancreas. Pancreatic cancer is the 3rd leading cause of cancer death for both sexes and while surgery is the only option for cure...

    Authors: Sofie Olsson Hau, Caroline Williamsson, Bodil Andersson, Jakob Eberhard and Karin Jirström
    Citation: BMC Cancer 2023 23:334
    Content type: Research Published on:

  37. Leptomeningeal metastasis (LM) is the most devastating complication of non-small cell lung cancer (NSCLC), and its incidence is increasing. There is currently no standard treatment for LM, and the efficacy of ...

    Authors: Tao Zhou, Shaofeng Zhu, Qiang Xiong, Jiongli Gan, Jianping Wei, Jing Cai and Anwen Liu
    Citation: BMC Cancer 2023 23:333
    Content type: Research Published on:

  38. The Arias-Stella reaction is a hormone-related atypical endometrial change characterized by cytomegaly, nuclear enlargement, and hyperchromasia of endometrial glands; typically associated with intrauterine or ...

    Authors: Fatemeh Nili, Masoumeh Sadri and Fereshteh Ameli
    Citation: BMC Cancer 2023 23:332
    Content type: Research Published on:

  39. As a potential target receptor tyrosine kinase, mesenchymal-epithelial transition factor (MET) exhibits high aberrant expression across various tumors. This study aimed to evaluated the safety, tolerability, effi...

    Authors: Xingsheng Hu, Xinge Cui, Ziping Wang, Yunpeng Liu, Ying Luo, Wei Zhong, Hui Zhao, Mengxing Yao, Da Jiang, Mingxia Wang, Minjiang Chen, Xin Zheng, Lieming Ding, Yang Wang, Xiaobin Yuan, Pengxiang Wu…
    Citation: BMC Cancer 2023 23:331
    Content type: Research Published on:

  40. Progesterone receptor (PR)-negative tumors have been shown to have worse prognosis and were underrepresented in recent trials on patients with estrogen receptor (ER)-positive breast cancer. The role of PR-nega...

    Authors: Sung Jun Ma, Jasmin Gill, Keerti Yendamuri, Udit Chatterjee, Olivia Waldman, Cynthia Dunne-Jaffe, Fatemeh Fekrmandi, Rohil Shekher, Austin Iovoli, Song Yao, Oluwadamilola T. Oladeru and Anurag K. Singh
    Citation: BMC Cancer 2023 23:330
    Content type: Research Published on:

  41. Most cases of lung cancer are diagnosed at advanced stage. Detection of genetic and epigenetic markers in cell-free DNA (cfDNA) is a promising tool for the diagnosis of lung cancer at an early stage. The aim o...

    Authors: Abla Abou-Zeid, Doaa Hashad, Ayman Baess, Mai Mosaad and Eman Tayae
    Citation: BMC Cancer 2023 23:329
    Content type: Research Published on:

  42. DTL has been found to be related with multiple cancers. However, comprehensive analyses, which identify the prediction value of DTL in diagnosis, prognosis, immune infiltration and treatment, have rarely been ...

    Authors: Yumei Tang, Ye Lei, Peng Gao, Junting Jia, Huijun Du, Qitong Wang, Zhixin Yan, Chen Zhang, Guojun Liang, Yanfeng Wang, Weijun Ma, Nianzeng Xing, Le Cheng and Laifeng Ren
    Citation: BMC Cancer 2023 23:328
    Content type: Research Published on:

  43. Neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy is a standard treatment for potentially curable esophageal cancer. Active surveillance in patients with a clinically complete response (cCR) 12 we...

    Authors: Charlène J. van der Zijden, Sjoerd M. Lagarde, Merel Hermus, Leonieke W. Kranenburg, J. Jan B. van Lanschot, Bianca Mostert, Joost J. M. E. Nuyttens, Lindsey Oudijk, Pieter C. van der Sluis, Manon C. W. Spaander, Maria J. Valkema, Roelf Valkema and Bas P. L. Wijnhoven
    Citation: BMC Cancer 2023 23:327
    Content type: Study protocol Published on:

  44. Despite immunotherapy’s promise in oncology, its use for sarcoma remains challenging. There are no sarcoma-specific biomarkers for immune checkpoint inhibitors (ICI). Previously, we reported our institutional ...

    Authors: Marium Husain, Dionisia Quiroga, Han Gil Kim, Scott Lenobel, Menglin Xu, Hans Iwenofu, James L. Chen, Claire Verschraegen, David Liebner and Gabriel Tinoco
    Citation: BMC Cancer 2023 23:326
    Content type: Research Published on:

  45. The survival benefit of adjuvant transarterial chemoembolization (TACE) in patients with hepatectomy for hepatocellular carcinoma (HCC) after hepatectomy remains controversial. We aimed to investigate the surv...

    Authors: Zhao Wu, Lifeng Cui, Junlin Qian, Laihui Luo, Shuju Tu, Fei Cheng, Lebin Yuan, WenJian Zhang, Wei Lin, Hongtao Tang, Xiaodong Li, Hui Li, Yang Zhang, Jisheng Zhu, Yong Li, Yuanpeng Xiong…
    Citation: BMC Cancer 2023 23:325
    Content type: Research Published on:

  46. Bladder cancer is the tenth most common cancer worldwide. For patients with T1 high-grade or T2 bladder cancer, radical cystectomy is recommended. However, radical cystectomy is associated with various complic...

    Authors: Xiangwei Yang, Shiqiang Zhang, Yajiao Cui, Yamei Li, Xinyue Song and Jun Pang
    Citation: BMC Cancer 2023 23:320
    Content type: Study Protocol Published on:

  47. Numerous studies have reported the prognostic significance of the red cell distribution width (RDW) in patients with esophageal squamous cell carcinoma (ESCC), but the relationship between the perioperative ch...

    Authors: Peng Zhang, Sheng Wang, Jun-zhou Wu and Qian Song
    Citation: BMC Cancer 2023 23:319
    Content type: Research Published on:

  48. Immunotherapy has made significant advances in the treatment of extensive-stage small-cell lung cancer (ES-SCLC), but data in combination with radiotherapy are scarce. This study aims to assess the safety and ...

    Authors: Lijuan Li, Dan Yang, Yanmei Min, Anyan Liao, Jing Zhao, Leilei Jiang, Xin Dong, Wei Deng, Huiming Yu, Rong Yu, Jun Zhao and Anhui Shi
    Citation: BMC Cancer 2023 23:318
    Content type: Research Published on:

  49. Drug-induced interstitial lung disease (ILD) is not a rare adverse event in the current chemotherapy strategy for pancreatic ductal adenocarcinoma (PDAC). Thus, we aimed to find the optimal management for PDAC...

    Authors: Hiroki Irie, Rei Suzuki, Yoshinori Okubo, Hiroyuki Asama, Naoki Konno, Yuki Noguchi, Ko Watanabe, Goro Shibukawa, Hidemichi Imamura, Tadayuki Takagi, Mitsuru Sugimoto, Yuki Sato, Jun Nakamura, Tsunetaka Kato, Minami Hashimoto, Takumi Yanagita…
    Citation: BMC Cancer 2023 23:316
    Content type: Research Published on:

  50. DNA methylation is one of the most promising biomarkers in predicting the prognosis of colorectal cancer (CRC). We aimed to develop a DNA methylation biomarker that could evaluate the prognosis of CRC.

    Authors: Xuan Li, Du Cai, Yaoyi Huang, Yumo Xie, Dingcheng Shen, Ze Yuan, Xiaoxia Liu, Meijin Huang, Yanxin Luo, Huichuan Yu and Xiaolin Wang
    Citation: BMC Cancer 2023 23:315
    Content type: Research Published on:

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