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  1. Total neoadjuvant therapy (TNT) is a novel treatment strategy that is an alternative to preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). However, an optimal protocol for TNT has ...

    Authors: Shinya Abe, Kazushige Kawai, Hiroaki Nozawa, Kazuhito Sasaki, Koji Murono, Shigenobu Emoto, Yuichiro Yokoyama, Hiroyuki Matsuzaki, Yuzo Nagai, Yuichiro Yoshioka, Takahide Shinagawa, Hirofumi Sonoda, Yoko Yamamoto, Koji Oba and Soichiro Ishihara
    Citation: BMC Cancer 2023 23:450
    Content type: Study Protocol Published on:

  2. Up to 70% of breast cancer patients report symptoms of insomnia during and after treatment. Despite the ubiquity of insomnia symptoms, they are under-screened, under-diagnosed and poorly managed in breast canc...

    Authors: Chloé Drozd, Elsa Curtit, Quentin Jacquinot, Charlène Marquine, Laura Mansi, Loïc Chaigneau, Erion Dobi, Julien Viot, Guillaume Meynard, Marie-Justine Paillard, Morgan Goujon, Pauline Roux, Dewi Vernerey, Valérie Gillet, Hubert Bourdin, Silvio Galli…
    Citation: BMC Cancer 2023 23:449
    Content type: Study Protocol Published on:

  3. Suboptimal treatment upon progression may affect overall survival (OS) results in oncology randomized controlled trials (RCTs). We aim to assess the proportion of trials reporting post-progression treatment.

    Authors: Timothée Olivier, Alyson Haslam and Vinay Prasad
    Citation: BMC Cancer 2023 23:448
    Content type: Research Published on:

  4. Leukemic cell metabolism plays significant roles in their proliferation and survival. These metabolic adaptations are under regulation by different factors. Programmed Death Ligand -1 (CD-274) is one of the im...

    Authors: Mojdeh Soltani, Mustafa Ghanadian, Behrooz Ghezelbash, Abolfazl Shokouhi, Andrey A. Zamyatnin Jr, Alexandr V. Bazhin and Mazdak Ganjalikhani-Hakemi
    Citation: BMC Cancer 2023 23:447
    Content type: Research article Published on:

  5. Upfront high-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) remains a profitable strategy for newly diagnosed multiple myeloma (MM) patients in the context of novel agents. However,...

    Authors: Chi-Maw Lin, Lih-Chyun Chang, Wen-Yi Shau, Chi-Ling Chen, Chi-Yuan Yao and Feng-Ming Tien
    Citation: BMC Cancer 2023 23:446
    Content type: Research Published on:

  7. Cholangiocarcinoma (CHOL) is the second most common primary hepatic malignant tumor, following hepatocellular carcinoma (HCC). CHOL is highly aggressive and heterogeneous resulting in poor prognosis. The diagn...

    Authors: Shuochen Liu, Shilong Fan, Yirui Wang, Ruixiang Chen, Ziyi Wang, Yaodong Zhang, Wangjie Jiang, Yananlan Chen, Xiao Xu, Yue Yu, Changxian Li and Xiangcheng Li
    Citation: BMC Cancer 2023 23:444
    Content type: Research Published on:

  8. Immune checkpoint inhibitors (ICI)-based combination strategies have improved the survival outcomes in advanced non-small cell lung cancers; however, data regarding their efficacy remains limited for uncommon ...

    Authors: Lianxi Song, Fei Zhou, Tian Xu, Liang Zeng, Qing Xia, Zhan Wang, Li Deng, Yizhi Li, Haoyue Qin, Huan Yan, Zhe Huang, Jinye Mi, Qinqin Xu, Nong Yang, Caicun Zhou and Yongchang Zhang
    Citation: BMC Cancer 2023 23:443
    Content type: Research Published on:

  9. Many studies have explored the cost-effectiveness of immunotherapy versus chemotherapy alone. However, there is paucity of evidence on direct pharmacoeconomic studies related to immunotherapy combinations. Thu...

    Authors: Wen Hui, Ruomeng Song, Hongyu Tao, Zhixiang Gao, Min Zhu, Mingyue Zhang, Huazhang Wu, Daichen Gong, Xiyan Zhang and Yuanyi Cai
    Citation: BMC Cancer 2023 23:442
    Content type: Research Published on:

  10. The CDH1 gene codes for the epithelial-cadherin (E-cad) protein, which is embedded in the plasma membrane of epithelial cells to form adherens junctions. E-cad is known to be essential for maintaining the integri...

    Authors: Brihget Sicairos, Shorna Alam and Yuchun Du
    Citation: BMC Cancer 2023 23:441
    Content type: Research Published on:

  12. COVID-19 has impacted both society and medical care. While Germany entered the first lockdown in spring 2020, the PIKKO study (Patient information, communication and competence empowerment in oncology) was sti...

    Authors: Nico Schneider, Bernhard Strauss, Jutta Hübner, Christian Keinki, Florian Brandt, Sabine Rubai and Uwe Altmann
    Citation: BMC Cancer 2023 23:439
    Content type: Research Published on:

  13. Breast cancer is highly heterogeneous, suggesting that small but relevant subsets have been under-recognized. Rare and mainly triple-negative breast cancers (TNBCs) were recently found to exhibit tuft cell-lik...

    Authors: Yosuke Yamada, Ronald Simon, Kosuke Iwane, Yuki Nakanishi, Yasuhide Takeuchi, Akihiko Yoshizawa, Masahiro Takada, Masakazu Toi, Hironori Haga, Alexander Marx and Guido Sauter
    Citation: BMC Cancer 2023 23:438
    Content type: Research Published on:

  14. The most common subtype of ovarian cancer (OC) showing immunogenic potential is represented by the high-grade serous ovarian cancer (HGSOC), which is characterized by the presence of tumor-infiltrating immune ...

    Authors: Daniele Fanale, Chiara Brando, Lidia Rita Corsini, Sofia Cutaia, Mariano Catello Di Donna, Ugo Randazzo, Clarissa Filorizzo, Chiara Lisanti, Luigi Magrin, Vittorio Gurrera, Raffaella Romano, Alessandra Dimino, Tancredi Didier Bazan Russo, Daniel Olive, Salvatore Vieni, Gianni Pantuso…
    Citation: BMC Cancer 2023 23:437
    Content type: Research Published on:

  15. Liver metastasis is a poor prognostic factor for treatment of advanced cutaneous melanoma with either immunotherapy or targeted therapies. In this study we focused on NRAS mutated melanoma, a cohort with high unm...

    Authors: Bianca Dietsch, Céline Weller, Carsten Sticht, Carolina de la Torre, Martin Kramer, Sergij Goerdt, Cyrill Géraud and Sebastian A. Wohlfeil
    Citation: BMC Cancer 2023 23:436
    Content type: Research Published on:

  16. Gemcitabine (Gem) has been a standard first-line drug for pancreatic cancer (PCa) treatment; however, Gem's rapid metabolism and systemic instability (short half-life) limit its clinical outcome. The objective...

    Authors: Andriana Inkoom, Nkafu Bechem Ndemazie, Taylor Smith, Esther Frimpong, Raviteja Bulusu, Rosemary Poku, Xue Zhu, Bo Han, Jose Trevino and Edward Agyare
    Citation: BMC Cancer 2023 23:435
    Content type: Research Published on:

  18. Breast cancer is associated with alterations in lipid metabolism. The treatment of breast cancer can also affect serum lipid composition. The purpose of this study was the examination of serum fatty acids (FAs...

    Authors: Alicja Pakiet, Agata Jędrzejewska, Katarzyna Duzowska, Alina Wacławska, Patrycja Jabłońska, Jacek Zieliński, Adriana Mika, Tomasz Śledziński and Ewa Słomińska
    Citation: BMC Cancer 2023 23:433
    Content type: Research Published on:

  19. In recent years, an increasing number of studies have revealed that patients’ preoperative inflammatory response, coagulation function, and nutritional status are all linked to the occurrence, development, ang...

    Authors: Xiaozong Duan, Bo Yang, Chengbin Zhao, Boran Tie, Lei Cao and Yuyuan Gao
    Citation: BMC Cancer 2023 23:432
    Content type: Research Published on:

  20. Neoadjuvant chemotherapy (NAC) has become the standard therapeutic option for early high-risk and locally advanced breast cancer. However, response rates to NAC vary between patients, causing delays in treatme...

    Authors: Jieqiu Zhang, Qi Wu, Wei Yin, Lu Yang, Bo Xiao, Jianmei Wang and Xiaopeng Yao
    Citation: BMC Cancer 2023 23:431
    Content type: Research Published on:

  21. Pancreatic adenocarcinoma (PAAD) is a leading cause of malignancy-related deaths worldwide, and the efficacy of immunotherapy on PAAD is limited. Studies report that long non-coding RNAs (lncRNAs) play an impo...

    Authors: Yinjiang Zhang, Yao Wang, Xu He, Rongfei Yao, Lu Fan, Linyi Zhao, Binan Lu and Zongran Pang
    Citation: BMC Cancer 2023 23:430
    Content type: Research Published on:

  23. Cervical cancer (CC) rates are high in Uganda, yet CC screening rates are very low. Our peer advocacy group intervention, Game Changers for Cervical Cancer Prevention (GC-CCP), was shown to increase CC screeni...

    Authors: Joseph KB Matovu, Glenn J. Wagner, Margrethe Juncker, Eve Namisango, Kathryn Bouskill, Sylvia Nakami, Jolly Beyeza-Kashesya, Emmanuel Luyirika and Rhoda K. Wanyenze
    Citation: BMC Cancer 2023 23:428
    Content type: Research Published on:

  24. Though behavioral activation (BA) has been shown to be effective for depression, evidence in patients with advanced cancer has not been established. This study aimed to examine the effectiveness of a BA progra...

    Authors: Takatoshi Hirayama, Yuko Ogawa, Asao Ogawa, Emi Igarashi, Saaya Soejima, Kotone Hata, Yusuke Utsumi, Yuki Mashiko, Kyoka Ogata, Ayako Kayano, Yuko Yanai and Shin-ichi Suzuki
    Citation: BMC Cancer 2023 23:427
    Content type: Study Protocol Published on:

  25. In previous study, we found that the content of medium-chain fatty acid Caprylic Acid (FFA C8:0) may be an important risk factor of obesity induced prostate cancer (PCa). However, the relationship between FFA ...

    Authors: Xue Li, Chenggang Yuan, Bingqi Yang, Huai Pang, Wei Li, Menghuan Li, Yihan Tang, Dingling Ma, Jianxin Xie, Jingzhou Wang and Jun Zhang
    Citation: BMC Cancer 2023 23:426
    Content type: Research article Published on:

  26. Previously studies shown a potential risk of antihypertensive medicines in relation to cancer susceptibility, which creating significant debate in the scientific community and public concern. We sought to inve...

    Authors: Suna Wang, Li Xie, Jianlin Zhuang, Ying Qian, Guanglu Zhang, Xiaowei Quan, Lei Li, Herbert Yu, Weituo Zhang, Wensui Zhao and Biyun Qian
    Citation: BMC Cancer 2023 23:425
    Content type: Research Published on:

  27. The long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a cancer biomarker. Furthermore, fusion of the MALAT1 gene with glioma-associated oncogene 1 (GLI1) is a diagnostic marke...

    Authors: Taiji Hamada, Michiyo Higashi, Seiya Yokoyama, Toshiaki Akahane, Masanori Hisaoka, Hirotsugu Noguchi, Tatsuhiko Furukawa and Akihide Tanimoto
    Citation: BMC Cancer 2023 23:424
    Content type: Research Published on:

  29. Postoperative adjuvant chemotherapy (AC) is now well-accepted as standard for high-risk stage II and stage III colorectal cancer (CRC) patients, however the optimal time to initiate AC remains elusive.

    Authors: Yuchong Yang, Yao Lu, Hui Tan, Ming Bai, Xia Wang, Shaohua Ge, Tao Ning, Le Zhang, Jingjing Duan, Yansha Sun, Rui Liu, Hongli Li, Yi Ba and Ting Deng
    Citation: BMC Cancer 2023 23:422
    Content type: Research Published on:

  30. To compare the oncological outcomes of patients with FIGO 2018 stage IIIC cervical cancer (CC) involving different local tumor factors who underwent abdominal radical hysterectomy (ARH), neoadjuvant chemothera...

    Authors: Yanna Ye, Zhiqiang Li, Shan Kang, Yongxiu Yang, Bin Ling, Li Wang, Jilong Yao, Pengfei Li, Xueqin Wang, Shipeng Gong, Huijian Fan, Yanxiang Kong, Yuye Cao, Jinghe Lang, Ping Liu and Chunlin Chen
    Citation: BMC Cancer 2023 23:421
    Content type: Research Published on:

  31. Glioma is the most common and aggressive tumor in the adult brain. Recent studies have indicated that Zinc finger DHHC-type palmitoyltransferases (ZDHHCs) play vital roles in regulating the progression of glio...

    Authors: Zhen-Yuan Liu, Tian Lan, Feng Tang, Yong-Ze He, Jin-Sheng Liu, Jin-Zhou Yang, Xi Chen, Ze-Fen Wang and Zhi-Qiang Li
    Citation: BMC Cancer 2023 23:420
    Content type: Research Published on:

  32. Partial breast irradiation (PBI) is standard of care in low-risk breast cancer patients after breast-conserving surgery (BCS). Pre-operative PBI can result in tumor downstaging and more precise target definiti...

    Authors: Yasmin A. Civil, Arlene L. Oei, Katya M. Duvivier, Nina Bijker, Philip Meijnen, Lorraine Donkers, Sonja Verheijen, Zdenko van Kesteren, Miguel A. Palacios, Laura J. Schijf, Ellis Barbé, Inge R. H. M. Konings, C. Willemien Menke -van der Houven van Oordt, Paulien G. Westhoff, Hanneke J. M. Meijer, Gwen M. P. Diepenhorst…
    Citation: BMC Cancer 2023 23:419
    Content type: Study Protocol Published on:

  33. To evaluate the clinical efficacy of percutaneous biliary drainage (PBD) combined with 125I seed strand brachytherapy (ISSB) for the treatment of hilar cholangiocarcinoma (HCCA).

    Authors: Chengzhi Zhang, Mengyao Song, Zhanguo Sun, Yi Fang, Yiming Liu, Kaihao Xu, Xinwei Han and Dechao Jiao
    Citation: BMC Cancer 2023 23:418
    Content type: Research Published on:

  34. PTPRF interacting protein alpha 1 (PPFIA1) is reportedly related to the occurrence and progression of several kinds of malignancies. However, its role in esophageal squamous cell carcinoma (ESCC) is unclear. T...

    Authors: Yongyin Gao, Lizhao Guan, Ran Jia, Wanyi Xiao, Youming Han, Yue Li, Peng Tang, Zhentao Yu and Hongdian Zhang
    Citation: BMC Cancer 2023 23:417
    Content type: Research Published on:

  35. Pathologic complete response (pCR) following preoperative systemic therapy is associated with improved outcomes after subsequent liver transplant/resection in hepatocellular carcinoma (HCC). However, the relat...

    Authors: Cheng Huang, Xiao-Dong Zhu, Ying-Hao Shen, Bin Xu, Dong Wu, Yuan Ji, Ling-Li Chen, Tian-Qiang Song, Wei Zhang, Zhi-Ming Zeng, Hua-Sheng Huang, Kui Wang, Lan-Qing Huang, Yong-Jun Chen, Yu-Chen Yang, Le-Du Zhou…
    Citation: BMC Cancer 2023 23:416
    Content type: Research Published on:

  36. Ferroptosis is iron-dependent non-apoptotic cell death, that is characterized by the excessive accumulation of lipid peroxides. Ferroptosis-inducing therapy also shows promise in the treatment of cancers. Howe...

    Authors: Xinzhuang Wang, Hong Zhang, Mingchu Zhang, Xuezhi Zhang, Wenbin Mao and Ming Gao
    Citation: BMC Cancer 2023 23:415
    Content type: Research Published on:

  38. Recent reports suggested combining ramucirumab with epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) to overcome EGFR resistance in non–small cell lung cancer (NSCLC). Nonetheless, evi...

    Authors: Chun-Yao Huang, Hui-Li Huang, Chou-Chin Lan, Yi-Chih Huang and Yao-Kuang Wu
    Citation: BMC Cancer 2023 23:413
    Content type: Research Published on:

  39. Papillary thyroid cancer (PTC) is the most frequent subtype of thyroid cancer, but 20% of cases are indeterminate (i.e., cannot be accurately diagnosed) based on preoperative cytology, which might lead to surg...

    Authors: Guochao Ye, Xiaomei Zhang, Mansheng Li, Zixiang Lin, Yongcan Xu, Haoru Dong, Jie Zhou, Jiaqi Zhang, Sheng Wang, Yunping Zhu, Xiaobo Yu and Xu Qian
    Citation: BMC Cancer 2023 23:412
    Content type: Research Published on:

  40. We used pyroptosis-related genes to establish a risk–score model for prognostic prediction of liver hepatocellular carcinoma (LIHC) patients. A total of 52 pyroptosis-associated genes were identified. Then, da...

    Authors: Xinyi Chen, Mu Yang, Lu Wang, Yuan Wang, Jingyao Tu, Xiao Zhou and Xianglin Yuan
    Citation: BMC Cancer 2023 23:411
    Content type: Research Published on:

  41. To develop and validate a predictive nomogram for tumor residue 3–6 months after treatment based on postradiotherapy plasma Epstein–Barr virus (EBV) deoxyribonucleic acid (DNA), clinical stage, and radiotherap...

    Authors: Ying-Ying Huang, Jia-Yu Zhou, Ze-Jiang Zhan, Liang-Ru Ke, Wei-Xiong Xia, Xun Cao, Zhuo-Chen Cai, Ying Deng, Xi Chen, Lu-Lu Zhang, Hao-Yang Huang, Xiang Guo and Xing Lv
    Citation: BMC Cancer 2023 23:410
    Content type: Research Published on:

  42. To increase the chances of finding efficacious anticancer drugs, improve development times and reduce costs, it is of interest to rank test compounds based on their potential for human use as early as possible...

    Authors: Marcus Baaz, Tim Cardilin, Floriane Lignet, Astrid Zimmermann, Samer El Bawab, Johan Gabrielsson and Mats Jirstrand
    Citation: BMC Cancer 2023 23:409
    Content type: Research article Published on:

  44. Worldwide, a significant proportion of head and neck cancers is attributed to the Human papillomavirus (HPV). It is imperative that we acquire a solid understanding of the natural history of this virus in head...

    Authors: Aviane Auguste, Stanie Gaete, Léah Michineau, Cécile Herrmann-Storck, Clarisse Joachim, Suzy Duflo, Jacqueline Deloumeaux and Danièle Luce
    Citation: BMC Cancer 2023 23:407
    Content type: Research Published on:

  45. Diagnosis and treatment of diffuse malignant peritoneal mesothelioma (DMPM) are still challenging. The aim of the present study was to explore the correlation between CD74, CD10, Ki-67 and clinicopathological ...

    Authors: Yufei Liang, Chunying Li, Yingying Liu, Liang Tian and Dongliang Yang
    Citation: BMC Cancer 2023 23:406
    Content type: Research Published on:

  46. Cervical cancer incidence and mortality rates are high in older women in many developed countries, including Denmark. Therefore, Danish women aged 69 and older were invited for one additional human papilloma v...

    Authors: Berit B. Booth, Mette Tranberg, Line W. Gustafson, Anne G. Christiansen, Helle Lapirtis, Lisa M. Krogh, Ina Marie D. Hjorth and Anne Hammer
    Citation: BMC Cancer 2023 23:405
    Content type: Research Published on:

  47. Regorafenib, a multikinase inhibitor, causes a high frequency of hand-foot skin reactions (HFSRs). The present study evaluated the efficacy of topical aluminum chloride, a perspiration suppressant, in reducing...

    Authors: Aya Nishizawa, Eiji Shinozaki, Takeru Wakatsuki, Takahiro Satoh, Naoya Yamazaki, Shunsuke Oyamada, Keisuke Ariyoshi, Kota Kihara, Masahiro Tsuboi and Kensei Yamaguchi
    Citation: BMC Cancer 2023 23:401
    Content type: Research Published on:

  48. Pre-operative long-course chemoradiotherapy (CRT) for rectal cancer has resulted in improvement in rates of restorative rectal resection and local recurrence by inducing tumour downstaging and downsizing. Tota...

    Authors: Raeed Deen, Dileepa S Ediriweera, Suchintha Thillakaratne, Janaki Hewavissenthi, Sumudu K Kumarage and Pramodh C. Chandrasinghe
    Citation: BMC Cancer 2023 23:400
    Content type: Research Published on:

  49. To summarize recent evidence in terms of health-related quality of life (HRQoL), functional and oncological outcomes following radical prostatectomy (RP) compared to external beam radiotherapy (EBRT) and andro...

    Authors: Berdine L. Heesterman, Katja K. H. Aben, Igle Jan de Jong, Floris J. Pos and Olga L. van der Hel
    Citation: BMC Cancer 2023 23:398
    Content type: Research Published on:

  50. This study aimed to explore the association between drinking water source and risk of upper gastrointestinal (UGI) cancer, including esophageal cancer (EC) and gastric cancer (GC), in the Linxian General Popul...

    Authors: Huan Yang, Jian-bing Wang, Xiao-kun Wang, Jin-hu Fan and You-lin Qiao
    Citation: BMC Cancer 2023 23:397
    Content type: Research Published on:

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