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  1. Content type: Research article

    Greater family size measured with total fertility rate (TFR) and with household size, may offer more life satisfaction to the family members. Positive psychological well-being has been postulated to decrease c...

    Authors: Wenpeng You, Frank J Rühli, Renata J Henneberg and Maciej Henneberg

    Citation: BMC Cancer 2018 18:924

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  2. Content type: Study protocol

    There is a pressing need to reduce the burden of chronic disease and improve healthcare system sustainability through improved cancer and chronic disease prevention and screening (CCDPS) in primary care. We ai...

    Authors: Donna Patricia Manca, Carolina Fernandes, Eva Grunfeld, Kris Aubrey-Bassler, Melissa Shea-Budgell, Aisha Lofters, Denise Campbell-Scherer, Nicolette Sopcak, Mary Ann O’Brien, Christopher Meaney, Rahim Moineddin, Kerry McBrien, Ginetta Salvalaggio and Paul Krueger

    Citation: BMC Cancer 2018 18:927

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  3. Content type: Study protocol

    Improved risk stratification, more effective therapy and better supportive care have resulted in survival rates after childhood cancer of around 80% in developed countries. Treatment however can be harsh, and ...

    Authors: Anne-Lotte L. F. van der Kooi, Eva Clemens, Linda Broer, Oliver Zolk, Julianne Byrne, Helen Campbell, Marleen van den Berg, Claire Berger, Gabriele Calaminus, Uta Dirksen, Jeanette Falck Winther, Sophie D Fosså, Desiree Grabow, Riccardo Haupt, Melanie Kaiser, Tomas Kepak…

    Citation: BMC Cancer 2018 18:930

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  4. Content type: Research article

    Cancer stem cells (CSC) are characterized by deregulated self-renewal, tumorigenicity, metastatic potential, aberrant stemness signaling pathways, resistance to conventional therapy, and the ability to give ri...

    Authors: Gabriele Davide Bigoni-Ordóñez, Elizabeth Ortiz-Sánchez, Pedro Rosendo-Chalma, Heriberto A Valencia-González, Carmen Aceves and Alejandro García-Carrancá

    Citation: BMC Cancer 2018 18:928

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  5. Content type: Research article

    PRKAA1 encodes α-subunit of 5-AMP-activated protein kinase (AMPK), which has been implicated in the pathogenesis of carcinoma of the stomach. Previous works have suggested that polymorphisms in the PRKAA1 may be ...

    Authors: Minbin Chen, Baohu Jiang, Bangshun He, Min Tang, Ping Wang, Li Chen, Jianwei Lu and Peihua Lu

    Citation: BMC Cancer 2018 18:923

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  6. Content type: Research article

    Protein kinase inhibitors (PKIs) are currently tested in clinical studies (phase I-III) as an alternative strategy against (recurrent) ovarian cancer. Besides their anti-tumour efficacy, several PKIs have also...

    Authors: Dennis Lindenblatt, Nastassja Terraneo, Giovanni Pellegrini, Susan Cohrs, Philipp René Spycher, David Vukovic, Martin Béhé, Roger Schibli and Jürgen Grünberg

    Citation: BMC Cancer 2018 18:922

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  7. Content type: Research article

    Hospitalized cancer patients undergoing intensive or high-dose chemotherapy often experience a considerable decline in functional performance associated with the increased risk of adverse health events. Exerci...

    Authors: Antonia Pahl, Anja Wehrle, Sarah Kneis, Albert Gollhofer and Hartmut Bertz

    Citation: BMC Cancer 2018 18:920

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  8. Content type: Case report

    Perianal Paget’s disease (PPD) is a rare intraepithelial adenocarcinoma of the anal margin. Primary PPD likely represents intra-epithelial neoplasm from an apocrine source, whereas secondary disease may repres...

    Authors: Jéssica Silva dos Santos, Gabriel Alves Bonafé, José Aires Pereira, Danilo Toshio Kanno, Carlos Augusto Real Martinez and Manoela Marques Ortega

    Citation: BMC Cancer 2018 18:921

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  9. Content type: Study protocol

    Patients undergoing chemotherapy are highly burdened by side effects. These may be caused by the pharmacodynamics of the drug or be driven by psychological factors such as negative expectations or pre-conditio...

    Authors: Julia Quidde, Yiqi Pan, Melanie Salm, Armin Hendi, Sven Nilsson, Karin Oechsle, Alexander Stein and Yvonne Nestoriuc

    Citation: BMC Cancer 2018 18:916

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  10. Content type: Study protocol

    Immunochemical fecal occult blood tests (iFOBTs) are increasingly used for colorectal cancer (CRC) screening. In our preceding observational study, sensitivity for detecting advanced colorectal neoplasms by iF...

    Authors: Kaja Tikk, David Czock, Walter E. Haefeli, Annette Kopp-Schneider and Hermann Brenner

    Citation: BMC Cancer 2018 18:914

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  11. Content type: Research article

    Total P16 methylation (P16M), including P16 hydroxymethylation (P16H) and true-P16M, correlates with malignant transformation of oral epithelial dysplasia (OED). Both true-P16M and P16H are early events in carcin...

    Authors: Hongwei Liu, Zhaojun Liu, Xue-wei Liu, Si Xu, Lei Wang, Yang Liu, Jing Zhou, Liankun Gu, Yan Gao, Xiao-yong Liu, Huidong Shi, Zheng Sun and Dajun Deng

    Citation: BMC Cancer 2018 18:918

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  12. Content type: Study protocol

    Biannual ultrasound (US)—with or without alpha-fetoprotein (AFP)—is recommended by current guidelines for the surveillance of hepatocellular carcinoma (HCC). However, the inadequate sensitivity of US has been ...

    Authors: Chansik An, Do Young Kim, Jin-Young Choi, Kwang Hyub Han, Yun Ho Roh and Myeong-Jin Kim

    Citation: BMC Cancer 2018 18:915

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  13. Content type: Research article

    Hepatocellular carcinoma (HCC) is a common malignant tumor with high fatality rate. Recent studies reported that up-regulation of long non-coding RNA antisense non-coding RNA in the INK4 locus (lncRNA ANRIL) w...

    Authors: Deyu Huang, Chunhua Bi, Qingxi Zhao, Xueli Ding, Cheng Bian, Hui Wang, Ting Wang and Hua Liu

    Citation: BMC Cancer 2018 18:919

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  14. Content type: Study protocol

    Soft tissue sarcomas are a heterogeneous and rare group of solid tumors of mesenchymal origin that can arise anywhere in the body. Although surgical resection is the mainstay of treatment for patients with loc...

    Authors: Emily Z. Keung, Alexander J. Lazar, Keila E. Torres, Wei-Lien Wang, Janice N. Cormier, B. Ashleigh Guadagnolo, Andrew J. Bishop, Heather Lin, Kelly K. Hunt, Justin Bird, Valerae O. Lewis, Shreyaskumar R. Patel, Jennifer A. Wargo, Neeta Somaiah and Christina L. Roland

    Citation: BMC Cancer 2018 18:913

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  15. Content type: Study protocol

    Febrile neutropenia (FN) is a common occurrence during chemotherapy. Granulocyte colony-stimulating factors (G-CSFs) can significantly reduce the risk of FN. International guidelines recommend G-CSF for patien...

    Authors: Bernardo Leon Rapoport, Matti Aapro, Marianne Paesmans, Ronwyn van Eeden, Teresa Smit, Andriy Krendyukov and Jean Klastersky

    Citation: BMC Cancer 2018 18:917

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  16. Content type: Review

    Traditional therapeutics have encountered a bottleneck caused by diagnosis delay and subjective and unreliable assessment. Biomarkers can overcome this bottleneck and guide us toward personalized precision med...

    Authors: Liang Zhong, Yutong Liu, Kai Wang, Zhijing He, Zhaojian Gong, Zhili Zhao, Yaocheng Yang, Xiaofei Gao, Fangjie Li, Hanjiang Wu, Sheng Zhang and Lin Chen

    Citation: BMC Cancer 2018 18:911

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  17. Content type: Research article

    The combination of chemotherapy and L-asparaginase (L-ASP) treatment significantly increased survival rate in an adult patient with extranodal natural killer (NK)/T-cell lymphoma (NKTCL). However, hypersensitivit...

    Authors: Wen Zheng, Yuhuan Gao, Xiaoyan Ke, Weijing Zhang, Liping Su, Hanyun Ren, Ningjing Lin, Yan Xie, Meifeng Tu, Weiping Liu, Lingyan Ping, Zhitao Ying, Chen Zhang, Lijuan Deng, Xiaopei Wang, Yuqin Song…

    Citation: BMC Cancer 2018 18:910

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  18. Content type: Research article

    Women diagnosed with gynaecological cancer experience supportive care needs that require care provision to reduce the impact on their lives. International evidence suggests supportive care needs of women with ...

    Authors: Natalie Williams, Georgia Griffin, Victoria Farrell, Alethea Rea, Kevin Murray and Yvonne L. Hauck

    Citation: BMC Cancer 2018 18:912

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  19. Content type: Research article

    The treatment recommendations for Low-grade Gliomas (LGG) underwent profound changes due to results from RTOG 9802 published in April 2016. This work aims to investigate whether the results from the trial were...

    Authors: Christoph Straube, Kerstin A. Kessel, Friederike Schmidt-Graf, Sandro M. Krieg, Bernhard Meyer, Jens Gempt and Stephanie E. Combs

    Citation: BMC Cancer 2018 18:907

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  20. Content type: Research article

    This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC).

    Authors: Ruo-Xi Wang, Sheng Chen, Liang Huang and Zhi-Ming Shao

    Citation: BMC Cancer 2018 18:909

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  21. Content type: Research article

    Although there has been marked development in surgical techniques, there is no easy and fast method of predicting complications in minimally invasive surgeries. We evaluated whether the modified surgical Apgar...

    Authors: Seon Hee Park, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim

    Citation: BMC Cancer 2018 18:908

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  22. Content type: Research article

    Colorectal cancer (CRC) is an illness strongly influenced by sex and gender, with mortality rates in males significantly higher than females. There is still a dearth of understanding on where sex differences e...

    Authors: Alan White, Lucy Ironmonger, Robert J. C. Steele, Nick Ormiston-Smith, Carina Crawford and Amanda Seims

    Citation: BMC Cancer 2018 18:906

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  23. Content type: Research article

    There is an urgent need for more novel and efficacious therapeutic agents and strategies for the treatment of ovarian cancer - one of the most formidable female malignancies. These approaches should be based o...

    Authors: Vsevolod I. Kiselev, Levon A. Ashrafyan, Ekaterina L. Muyzhnek, Evgeniya V. Gerfanova, Irina B. Antonova, Olga I. Aleshikova and Fazlul H. Sarkar

    Citation: BMC Cancer 2018 18:904

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  24. Content type: Case report

    Endometriosis is a relatively common condition in women of reproductive age. Malignant transformation of intestinal endometriosis is a very rare event. We report a case in which a patient with a history of end...

    Authors: Ningning Li, Weixun Zhou, Lin Zhao and Jiaolin Zhou

    Citation: BMC Cancer 2018 18:905

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  25. Content type: Study protocol

    Magnetic resonance imaging (MRI) has improved capacity to visualize tumor and soft tissue involvement in head and neck cancers. Using advanced MRI, we can interrogate cell density using diffusion weighted imag...

    Authors: Sweet Ping Ng, Houda Bahig, Jihong Wang, Carlos E. Cardenas, Anthony Lucci, Carolyn S. Hall, Salyna Meas, Vanessa N. Sarli, Ying Yuan, Diana L. Urbauer, Yao Ding, Shane Ikner, Vi Dinh, Baher A. Elgohari, Jason M. Johnson, Heath D. Skinner…

    Citation: BMC Cancer 2018 18:903

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  26. Content type: Research article

    Interactions between cancer cells and the surrounding microenvironment are crucial determinants of cancer progression. During this process, bi-directional communication among tumor cells and cancer associated ...

    Authors: Francesca Andriani, Elena Landoni, Mavis Mensah, Federica Facchinetti, Rosalba Miceli, Elda Tagliabue, Marta Giussani, Maurizio Callari, Loris De Cecco, Mario Paolo Colombo, Luca Roz, Ugo Pastorino and Gabriella Sozzi

    Citation: BMC Cancer 2018 18:899

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  27. Content type: Research article

    Triple Negative Breast Cancer (TNBC) is an aggressive form of breast cancer, that represents 10–20% of all breast carcinomas and characterized by the lack of a specific cell surface marker compared to other br...

    Authors: Farah Jouali, Nabila Marchoudi, Salwa Talbi, Basma Bilal, Mohamed El Khasmi, Houria Rhaissi and Jamal Fekkak

    Citation: BMC Cancer 2018 18:900

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  28. Content type: Research article

    Accelerated malignant behaviors induced by insufficient thermal ablation have been increasingly reported, however, the exact mechanisms are still unclear. Here, we investigated the importance of the extracellu...

    Authors: Rui Zhang, Min Ma, Xia-Hui Lin, Hua-Hua Liu, Jie Chen, Jun Chen, Dong-Mei Gao, Jie-Feng Cui, Zheng-Gang Ren and Rong-Xin Chen

    Citation: BMC Cancer 2018 18:901

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  29. Content type: Study protocol

    Definitive chemoradiotherapy is standard of care in locally advanced cervical cancer (LACC). Both toxicity and local relapse remain major concerns in this treatment. We hypothesize that a magnetic resonance im...

    Authors: Katrien Vandecasteele, Philippe Tummers, Mieke Van Bockstal, Pieter De Visschere, Tom Vercauteren, Werner De Gersem, Hannelore Denys, Eline Naert, Amin Makar and Wilfried De Neve

    Citation: BMC Cancer 2018 18:898

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  30. Content type: Research article

    The only available predictive models for the outcome of breast cancer patients in New Zealand (NZ) are based on data in other countries. We aimed to develop and validate a predictive model using NZ data for th...

    Authors: J. Mark Elwood, Essa Tawfiq, Sandar TinTin, Roger J. Marshall, Tung M. Phung, Ian Campbell, Vernon Harvey and Ross Lawrenson

    Citation: BMC Cancer 2018 18:897

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  31. Content type: Research article

    Intestinal-type sinonasal adenocarcinomas (ITACs) are aggressive malignancies related to wood dust and leather exposure. ITACs are generally associated with advanced stage at presentation due to the insidious ...

    Authors: Marco Tomasetti, Massimo Re, Federica Monaco, Simona Gaetani, Corrado Rubini, Andrea Bertini, Ernesto Pasquini, Cristiana Bersaglieri, Massimo Bracci, Sara Staffolani, Mariastella Colomba, Armando Gregorini, Matteo Valentino, Adriano Tagliabracci, Massimo Bovenzi, Jiri Neuzil…

    Citation: BMC Cancer 2018 18:896

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  32. Content type: Research article

    An emerging immunotherapy is infusion of tumor infiltrating Lymphocytes (TIL), with objective response rates of around 50% versus 19% for ipilimumab. As an Advanced Therapeutic Medicinal Products (ATMP), TIL i...

    Authors: Valesca P. Retèl, Lotte M. G. Steuten, Marnix H. Geukes Foppen, Janne C. Mewes, Melanie A. Lindenberg, John B. A. G. Haanen and Wim H. van Harten

    Citation: BMC Cancer 2018 18:895

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  33. Content type: Research article

    Pseudogenes are RNA transcripts with high homology with its parent protein-coding genes. Although pseudogenes lost the ability to produce protein, it still exert import biological function, and play important ...

    Authors: Fengqiong Liu, Ruijie Gong, Baochang He, Fa Chen and Zhijian Hu

    Citation: BMC Cancer 2018 18:894

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  34. Content type: Research article

    Our goal was to investigate the prevalence of the epidermal growth factor receptor (EGFR) mutation in Middle East and African countries and to compare its prevalence with that shown in other populations.

    Authors: Zineb Benbrahim, Teresita Antonia and Nawfel Mellas

    Citation: BMC Cancer 2018 18:891

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  35. Content type: Research article

    Frailty is an indicator of physiological reserve in older people. In non-cancer settings, frailty indices are reliable predictors of adverse health outcomes. The aims of this study were to 1) derive and valida...

    Authors: A. L. McCarthy, N. M. Peel, K. M. Gillespie, R. Berry, E. Walpole, P. Yates and R. E. Hubbard

    Citation: BMC Cancer 2018 18:892

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  36. Content type: Research article

    Physical exercise and nutritional treatment are promising measures to prevent muscle wasting that is frequently observed in advanced-stage cancer patients. However, conventional exercise is not always suitable...

    Authors: Kristin Schink, Hans J. Herrmann, Raphaela Schwappacher, Julia Meyer, Till Orlemann, Elisabeth Waldmann, Bernd Wullich, Andreas Kahlmeyer, Rainer Fietkau, Dorota Lubgan, Matthias W. Beckmann, Carolin Hack, Wolfgang Kemmler, Jürgen Siebler, Markus F. Neurath and Yurdagül Zopf

    Citation: BMC Cancer 2018 18:886

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  37. Content type: Study protocol

    Treatment with programmed cell death receptor (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors is a promising strategy to lift tumour-induced immune response suppression. However, the current syste...

    Authors: J. Rotman, C. H. Mom, E. S. Jordanova, T. D. de Gruijl and G. G. Kenter

    Citation: BMC Cancer 2018 18:888

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  38. Content type: Case report

    Ameloblastoma is a slow-growing neoplasm of the jaw, for which the standard treatment is surgical removal of the lesion with high recurrence rates and elevated morbidity. Systemic therapy is not established in...

    Authors: Gustavo S. Fernandes, Daniel M. Girardi, João Paulo G. Bernardes, Felipe P. Fonseca and Eduardo R. Fregnani

    Citation: BMC Cancer 2018 18:887

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  39. Content type: Study protocol

    Accurate assessment of liver health prior to undertaking resectional liver surgery or chemoembolisation for primary and secondary cancers is essential for patient safety and optimal outcomes. LiverMultiScan™, an ...

    Authors: Damian J. Mole, Jonathan A. Fallowfield, Timothy J. Kendall, Fenella Welsh, Scott I. Semple, Velicia Bachtiar, Matt Kelly, Stephen J. Wigmore, O. James Garden, Henry R. Wilman, Rajarshi Banerjee, Myrddin Rees and Michael Brady

    Citation: BMC Cancer 2018 18:890

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  40. Content type: Case report

    We report on a female patient who underwent primary radical resection for a stage 2B Her-2-positive Barrett’s-type esophageal adenocarcinoma (EAC). Despite Her-2 targeted therapy, her disease recurred and requ...

    Authors: Federica Isidori, Deborah Malvi, Silvia Fittipaldi, Claudio Forcato, Isotta Bozzarelli, Claudia Sala, Giovanni Raulli, Antonia D’Errico, Michelangelo Fiorentino, Marco Seri, Kausilia K. Krishnadath, Elena Bonora and Sandro Mattioli

    Citation: BMC Cancer 2018 18:889

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  41. Content type: Research article

    Resection of the primary tumor is recommended for symptom relief in de novo stage IV breast cancer. We explored whether local surgery could provide a survival benefit in these patients and attempted to charact...

    Authors: Zhenchong Xiong, Guangzheng Deng, Jin Wang, Xing Li, Xinhua Xie, Zeyu Shuang and Xi Wang

    Citation: BMC Cancer 2018 18:885

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  42. Content type: Study protocol

    Cancer related fatigue (CRF) is one of the most prevalent and distressing long-term complaints reported by (non-) Hodgkin survivors. To date there has been no standard treatment for CRF in this population. A n...

    Authors: Daniëlle E. J. Starreveld, Laurien A. Daniels, Heiddis B. Valdimarsdottir, William H. Redd, Jessie L. de Geus, Sonia Ancoli-Israel, Susan Lutgendorf, Catharina M. Korse, Jacobien M. Kieffer, Flora E. van Leeuwen and Eveline M. A. Bleiker

    Citation: BMC Cancer 2018 18:880

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  43. Content type: Research article

    Local ablative techniques are emerging in patients with oligometastatic disease from colorectal carcinoma, commonly described as less invasive than surgical methods. This single arm cohort seeks to determine w...

    Authors: Ricarda Seidensticker, Robert Damm, Julia Enge, Max Seidensticker, Konrad Mohnike, Maciej Pech, Peter Hass, Holger Amthauer and Jens Ricke

    Citation: BMC Cancer 2018 18:882

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  44. Content type: Research article

    The aim of our study was to investigate whether an inflammation-based prognostic score, the prognostic nutritional index (PNI), was associated with clinical characteristics and prognosis in patients with high-...

    Authors: Zheng Feng, Hao Wen, Xingzhu Ju, Rui Bi, Xiaojun Chen, Wentao Yang and Xiaohua Wu

    Citation: BMC Cancer 2018 18:883

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  45. Content type: Research article

    The aim of this study was to develop nomograms for predicting the risk of locoregional recurrence or distant metastasis in esophageal cancer patients who were treated with esophagectomy and regional lymphadene...

    Authors: Wen-Yi Zhang, Xing-Xing Chen, Wen-Hao Chen, Hui Zhang and Chang-Lin Zou

    Citation: BMC Cancer 2018 18:879

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  46. Content type: Correction

    Following publication of the original article [1], the authors reported that the affiliation of author Annalisa Orenti was omitted.

    Authors: Elisabetta Venturelli, Annalisa Orenti, Aline S. C. Fabricio, Giulia Garrone, Roberto Agresti, Biagio Paolini, Chiara Bonini, Massimo Gion, Franco Berrino, Christine Desmedt, Danila Coradini and Elia Biganzoli

    Citation: BMC Cancer 2018 18:876

    Published on:

    The original article was published in BMC Cancer 2018 18:651

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