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  1. Osteosarcoma (OS) mainly happens in children and youths. Surgery, radiotherapy and chemotherapy are the common therapies for osteosarcoma treatment but all their anti-tumor effects are limited. In recent years...

    Authors: Qian Zhang, Zhiqiang Zhang, Guodi Liu, Dehua Li, Zhangjie Gu, Linsong Zhang, Yingjiao Pan, Xingbing Cui, Lu Wang, Guoping Liu, Xiaoli Tian and Ziming Zhang
    Citation: BMC Cancer 2022 22:1124
    Content type: Research Published on:

  2. IQ motif-containing GTPase-activating proteins (IQGAPs) are a group of scaffold proteins which have been identified to be involved in tumor initiation and progression in diverse types of cancer. Clinical studi...

    Authors: Qingqing Dai, Fei Song, Xincheng Li, Fan Huang and Hongchuan Zhao
    Citation: BMC Cancer 2022 22:1121
    Content type: Research Published on:

  3. Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated.

    Authors: Sehui Kim, Jaemoon Koh, Seung Geun Song, Jeemin Yim, Miso Kim, Bhumsuk Keam, Young Tae Kim, Jihun Kim, Doo Hyun Chung and Yoon Kyung Jeon
    Citation: BMC Cancer 2022 22:1120
    Content type: Research Published on:

  4. Colorectal cancer remains the second leading cause of cancer death in North America. Fluorouracil and oxaliplatin based adjuvant chemotherapy for resected colon cancer (CC) reduces cancer recurrence, but also ...

    Authors: Daniel Breadner, Jonathan M. Loree, Winson Y. Cheung, Meghan Gipson, Suganija Lakkunarajah, Karen E. Mulder, Jennifer L. Spartlin, Shiying Kong, Philip Q. Ding, Sharlene Gill and Stephen A. Welch
    Citation: BMC Cancer 2022 22:1119
    Content type: Research Published on:

  5. Solid pulmonary nodules are different from subsolid nodules and the diagnosis is much more challenging. We intended to evaluate the diagnostic and prognostic value of radiomics and deep learning technologies f...

    Authors: Rui Zhang, Ying Wei, Feng Shi, Jing Ren, Qing Zhou, Weimin Li and Bojiang Chen
    Citation: BMC Cancer 2022 22:1118
    Content type: Research Published on:

  6. The aim of this prospective study was to investigate the prognostic value of metabolic tumor volume (MTV) and apparent diffusion coefficient (ADC) from baseline FDG PET/MRI compared to established clinical ris...

    Authors: Trine Husby, Håkon Johansen, Trond Velde Bogsrud, Kari Vekseth Hustad, Birte Veslemøy Evensen, Ronald Boellaard, Guro F. Giskeødegård, Unn-Merete Fagerli and Live Eikenes
    Citation: BMC Cancer 2022 22:1117
    Content type: Research Published on:

  7. The linkage between IDO2 expression and cancer progression is still unclear, particularly in medullary thyroid carcinoma (MTC). Our purpose is to unveil the potential correlations between IDO2 status, clinical...

    Authors: Pengfei Gu, Bin Ling, Weike Ma, Jinming Zhang, Wei Zhang, Yu Zeng, Yu Liu, Jiadong Chi, Xianhui Ruan, Xiangqian Zheng, Songfeng Wei and Ming Gao
    Citation: BMC Cancer 2022 22:1116
    Content type: Research Published on:

  8. Women with breast cancer are at risk for the development of sarcopenia and occurrence of fractures. The initial and periodic screening of these conditions can prevent the risks of disability, poor quality of l...

    Authors: Rayne de Almeida Marques Bernabé, Mariana de Souza Vieira, Vanusa Felício de Souza, Luana Gomes Fontana, Ben-Hur Albergaria, José Luiz Marques-Rocha and Valdete Regina Guandalini
    Citation: BMC Cancer 2022 22:1115
    Content type: Research Published on:

  9. This study aimed to report the prevalence of HER2-neu in newly diagnosed early or metastatic gastric cancer (GC) patients, to determine the percentage of patients achieving various IHC scores correlating with ...

    Authors: Joseph Kattan, Fady el Karak, Fadi Farhat, Dany Abi Gerges, Walid Mokaddem, Georges Chahine, Saad Khairallah, Najla Fakhruddin, Jawad Makarem and Fadi Nasr
    Citation: BMC Cancer 2022 22:1114
    Content type: Research Published on:

  10. Overall survival of advanced colorectal cancer (CRC) patients remains poor, and gene expression analysis could potentially complement detection of clinically relevant mutations to personalize CRC treatments.

    Authors: Maxim Sorokin, Marianna Zolotovskaia, Daniil Nikitin, Maria Suntsova, Elena Poddubskaya, Alexander Glusker, Andrew Garazha, Alexey Moisseev, Xinmin Li, Marina Sekacheva, David Naskhletashvili, Alexander Seryakov, Ye Wang and Anton Buzdin
    Citation: BMC Cancer 2022 22:1113
    Content type: Research Published on:

  11. Worldwide, esophageal cancer (EC) is a common cancer in term of incidence and mortality and is the 4th common cancer in Afghanistan. Current study aimed to evaluate the profile of risk factors for EC among pat...

    Authors: Ramin Saadaat, Jamshid Abdul-Ghafar, Ahmed Nasir Hanifi, Saifullah Khalid, Abdul Latif Khairy, Abdul Sami Ibrahimkhil, Haider Ali Malakzai, Esmatullah Esmat, Mujtaba Haidari, Nasrin Hussaini, Najla Nasir, Sarah Noor and Ahmed Maseh Haidary
    Citation: BMC Cancer 2022 22:1112
    Content type: Research Published on:

  12. This study investigated site-specific differences in clinical factors for recurrence in patients who were newly diagnosed and treated for endometrial cancer. A model for predicting recurrence sites was generated.

    Authors: Wonkyo Shin, Seong J. Yang, Sang-Yoon Park, Sokbom Kang, Dong Ock Lee, Myong Cheol Lim and Sang-Soo Seo
    Citation: BMC Cancer 2022 22:1111
    Content type: Research Published on:

  13. Lung cancer is currently the most frequent cancer in Jiangsu Province, China, and the features of cancer distribution have changed continuously in the last decade. The aim of this study was to analyse the tren...

    Authors: Yuchen Jiang, Renqiang Han, Jian Su, Xikang Fan, Hao Yu, Ran Tao and Jinyi Zhou
    Citation: BMC Cancer 2022 22:1110
    Content type: Research Published on:

  14. Most patients with cancer and their caregivers desire honest, clear prognostic communication, yet oncologists often disclose prognosis inconsistently. Prognostic communication becomes even more challenging whe...

    Authors: Amy S. Porter, Cameka Woods, Melanie Stall, Srilakshmi Velrajan, Justin N. Baker, Jennifer W. Mack and Erica C. Kaye
    Citation: BMC Cancer 2022 22:1109
    Content type: Research Published on:

  15. The clinical significance of tertiary lymphoid structures (TLSs) is not well-documented in early oral tongue squamous cell carcinoma (OTSCC).

    Authors: Alhadi Almangush, Ibrahim O. Bello, Amr Elseragy, Jaana Hagström, Caj Haglund, Luiz Paulo Kowalski, Pentti Nieminen, Ricardo D. Coletta, Antti A. Mäkitie, Tuula Salo and Ilmo Leivo
    Citation: BMC Cancer 2022 22:1108
    Content type: Research Published on:

  16. AZD0156 is an oral inhibitor of ATM, a serine threonine kinase that plays a key role in DNA damage response (DDR) associated with double-strand breaks. Topoisomerase-I inhibitor irinotecan is used clinically t...

    Authors: S. Lindsey Davis, Sarah J. Hartman, Stacey M. Bagby, Marina Schlaepfer, Betelehem W. Yacob, Tonia Tse, Dennis M. Simmons, Jennifer R. Diamond, Christopher H. Lieu, Alexis D. Leal, Elaine B. Cadogan, Gareth D. Hughes, Stephen T. Durant, Wells A. Messersmith and Todd M. Pitts
    Citation: BMC Cancer 2022 22:1107
    Content type: Research article Published on:

  17. Hepatocellular carcinoma (HCC) is a global health problem with regional differences in epidemiological statistics. Co-assembling the drug nanoparticles and targeting moieties could improve the therapeutic deli...

    Authors: Ahmed A. Abd-Rabou, Hanaa H. Ahmed and Mohamed S. Kishta
    Citation: BMC Cancer 2022 22:1106
    Content type: Research Published on:

  18. Endoscopic screening is the widely accepted screening strategy for esophageal squmaous cell carcinoma (ESCC). However, massive endoscopic screening is expensive and not cost-efficient, and novel pre-endoscopy ...

    Authors: Yadong Feng, Bin Wang, Liang Pan, Bin Yao, Bin Deng, Yan Liang, Yongzhen Sun, Juncai Zang, Xinyi Xu, Jie Song, Mengjie Li, Guangpeng Xu, Kai Zhao, Cui-E. Cheng and Ruihua Shi
    Citation: BMC Cancer 2022 22:1105
    Content type: Study protocol Published on:

  19. An over-expression of the epidermal growth factor receptor (EGFR) has been observed in colorectal cancer and is associated with aggressive disease and poor prognosis. SCT200 is a newly developed recombinant, f...

    Authors: Wen Zhang, Xiaohong Han, Lin Yang, Yuanyuan Song, Liangzhi Xie, Wenlin Gai, Yan Wang and Yuankai Shi
    Citation: BMC Cancer 2022 22:1104
    Content type: Research Published on:

  20. The specific differentiation potential, unlimited proliferation, and self-renewal capacity of cancer stem cells (CSCs) are closely related to the occurrence, recurrence, and drug resistance of hepatocellular c...

    Authors: Genhao Zhang, Kai Zhang, Yanteng Zhao, Qiankun Yang and Xianping Lv
    Citation: BMC Cancer 2022 22:1103
    Content type: Research Published on:

  22. Postoperative chemoradiotherapy (CRT) is a standard therapy for patients with high-risk factors for head and neck squamous cell carcinoma, including positive margin and extra-nodal extension (ENE). However, th...

    Authors: Ari Nishimura, Tomoya Yokota, Satoshi Hamauchi, Yusuke Onozawa, Akifumi Notsu, Fuyuki Sato, Takeshi Kawakami, Hirofumi Ogawa, Tsuyoshi Onoe and Takashi Mukaigawa
    Citation: BMC Cancer 2022 22:1101
    Content type: Research Published on:

  23. Increasing evidence has convincingly shown that abnormal pre-mRNA splicing is implicated in the development of most human malignancies. Serine/arginine-rich protein kinase 1 (SRPK1), a key splicing regulator, ...

    Authors: Cuiying He, Beichen Liu, Huan-You Wang, Lili Wu, Guimin Zhao, Chen Huang, Yueping Liu, Baoen Shan and Lihong Liu
    Citation: BMC Cancer 2022 22:1100
    Content type: Research Published on:

  24. IMpassion130 led to the approval of atezolizumab plus nab-paclitaxel as first-line treatment for patients with unresectable locally advanced or metastatic triple-negative, PD-L1 immune-cell positive breast can...

    Authors: Christine Deutschmann, Rupert Bartsch, Christian F Singer, Daphne Gschwantler-Kaulich, Michael Seifert, Carmen Leser, Maximilian Marhold, Zsuzsanna Bago-Horvath and Georg Pfeiler
    Citation: BMC Cancer 2022 22:1099
    Content type: Research Published on:

  25. Increasing evidence shows that liver-specific long non-coding RNAs (lncRNAs) play important roles in the development of hepatocellular carcinoma (HCC). We identified a novel liver-specific lncRNA, FAM99A, and ...

    Authors: Meile Mo, Xiaoyun Ma, Yihuan Luo, Chao Tan, Bihu Liu, Peng Tang, Qian Liao, Shun Liu, Hongping Yu, Dongping Huang, Xiaoyun Zeng and Xiaoqiang Qiu
    Citation: BMC Cancer 2022 22:1098
    Content type: Research Published on:

  26. Existing research on the perspectives of patients with cancer and health care professionals indicates that patient decision making on cancer clinical trial participation is a complex process and may be poorly ...

    Authors: Line Hillersdal, Zandra Engelbak Nielsen, Ane Taudorf Nørmark, Ann Knoop and Karin Piil
    Citation: BMC Cancer 2022 22:1097
    Content type: Research Published on:

  27. Cervical cancer (CC) is the number one leading cause of death among women in Malawi. However, it is generally viewed as preventable and treatable if diagnosed in an early stage. Despite the burden, Malawi regi...

    Authors: Felistas Mpachika-Mfipa, Lucy Ida Kululanga, Abigail Kazembe and Dumisani Mfipa
    Citation: BMC Cancer 2022 22:1096
    Content type: Research Published on:

  28. Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, with overall survival remaining poor despite ongoing efforts to explore new treatment paradigms. Given these outcomes, efforts hav...

    Authors: Matthew Gallitto, Michelle Savacool, Albert Lee, Tony J. C. Wang and Michael B. Sisti
    Citation: BMC Cancer 2022 22:1095
    Content type: Research Published on:

  30. As a human tumor disease, head and neck squamous cell carcinoma (HNSCC) is associated with a high mortality rate worldwide. Nicotinic acetylcholine receptors (nAChRs) are transmembrane receptor proteins and ex...

    Authors: Yujie Shen, Qiang Huang, Mengyou Ji, Chi-Yao Hsueh and Liang Zhou
    Citation: BMC Cancer 2022 22:1093
    Content type: Research Published on:

  31. Antibodies and derivative drugs targeting immune checkpoints have been approved for the treatment of several malignancies, but there are fewer responses in patients with pancreatic cancer. Here, we designed a ...

    Authors: Shuai Hao, Shuyi Xu, Liangzhu Li, Yaxian Li, Meiqi Zhao, Junsheng Chen, Shunying Zhu, Yueqing Xie, Hua Jiang, Jianwei Zhu and Mingyuan Wu
    Citation: BMC Cancer 2022 22:1092
    Content type: Research Published on:

  34. A large proportion of indigenous African (IA) colorectal cancer (CRC) patients in South Africa are young (< 50 years), with no unique histopathological or molecular characteristics. Anatomical site as well as ...

    Authors: Michelle McCabe, Clement Penny, Pumza Magangane, Sheefa Mirza and Yvonne Perner
    Citation: BMC Cancer 2022 22:1089
    Content type: Research Published on:

  35. To study the pattern and treatment outcome of rectal cancer (RC) with concurrent locoregional recurrence (LR) and distant metastasis (DM) after total mesorectal excision (TME) and to identify patient-, disease...

    Authors: Yikuan Chen, Yaqi Li, Shaobo Mo, Xiang Hu, Fangqi Liu, Sanjun Cai, Xiaoji Ma and Junjie Peng
    Citation: BMC Cancer 2022 22:1088
    Content type: Research Published on:

  36. The number of persons who have survived cancer has been increasing in India as elsewhere due to advances in detection and treatment of this disease. However, evidence on the standardised number of cancer survi...

    Authors: Aravinda Meera Guntupalli, Y. Selvamani, Sara J. Maclennan and T. R. Dilip
    Citation: BMC Cancer 2022 22:1087
    Content type: Research Published on:

  37. Chemoradiotherapy (CRT), which might affect the autonomic system, is the mainstay therapy for advanced esophageal squamous cell carcinoma (ESCC). Autonomic dysfunction has been found to possibly lead to cancer...

    Authors: Chen-Ling Tang, Wei-Chung Tsai, Jui-Ying Lee, Yao-Kuang Wang, Yi-Hsun Chen, Yu-Wei Liu, Ming-Chieh Lin, Pen-Tzu Fang, Yu-Ling Huang and I-Chen Wu
    Citation: BMC Cancer 2022 22:1086
    Content type: Research Published on:

  38. Cancer therapy has evolved from non-specific cytotoxic agents to a selective, mechanism-based approach that includes targeted agents and immunotherapy. Although the response to targeted therapies for unresecta...

    Authors: Teng-Kai Yang, Ya-Fang Yu, Chiao-Ling Tsai, Hsing-Ju Li, Po-Sheng Yang, Kai-Wen Huang and Jason Chia-Hsien Cheng
    Citation: BMC Cancer 2022 22:1085
    Content type: Research Published on:

  39. This study aimed to determine whether drug doses per kilogram of lean body mass (LBM) were associated with dose-limiting toxicity (DLT) events in head and neck cancer (HNC) patients.

    Authors: Chuan-Jen Hung, Bor-Hwang Kang, Keng-Ming Chang, Ying-Ying Kang, Chun-Hao Yin and Ching-Chih Lee
    Citation: BMC Cancer 2022 22:1084
    Content type: Research article Published on:

  40. To review our long-term clinical experience, analyze the failure patterns, and give suggestions for target volume delineation of carcinoma showing thymus-like differentiation (CASTLE) treated with intensity-mo...

    Authors: Fang-Fang Kong, Guang-Sen Pan, Rui-Ping Zhai, Cheng-Run Du, Xia-Yun He, Chun-Ying Shen, Xue-Guan Lu, Tuan-Qi Sun, Yu Wang, Qing-Hai Ji, Chao-Su Hu and Hong-Mei Ying
    Citation: BMC Cancer 2022 22:1083
    Content type: Research Published on:

  41. The tumour–stroma ratio (TSR) is identified as a promising prognostic parameter for breast cancer, but the cutoff TSR value is mostly assessed by visual assessment, which lacks objective measurement. The aims ...

    Authors: Dandan Yan, Xianli Ju, Bin Luo, Feng Guan, Huihua He, Honglin Yan and Jingping Yuan
    Citation: BMC Cancer 2022 22:1082
    Content type: Research Published on:

  42. HER2 expression has a prognostic and predictive impact in early-stage breast cancer (BC). HER2 positive BC (immunohistochemistry (IHC) score 3 + or 2 + with in situ hybridization (ISH) amplification) are treat...

    Authors: François Cherifi, Angélique Da Silva, Alison Johnson, Cécile Blanc-Fournier, Olivia Abramovici, Antonin Broyelle, Christelle Levy, Djelila Allouache, Ioana Hrab, Carine Segura, Adeline Morel, Maud Villemin, Clémence Boscher, Coraline Dubot-Poitelon, Pauline Rottier, Justine Lequesne…
    Citation: BMC Cancer 2022 22:1081
    Content type: Research Published on:

  43. Systemic inflammation is currently regarded as a hallmark of cancer. This study aimed to accurately clarify the prognostic value of various inflammatory markers in patients with stage IV cancer.

    Authors: He-Yang Zhang, Hai-Lun Xie, Guo-Tian Ruan, Qi Zhang, Yi-Zhong Ge, Xiao-Yue Liu, Meng Tang, Meng-Meng Song, Shi-Qi Lin, Ming Yang, Xiao-Wei Zhang, Hong-Xia Xu, Chun-Hua Song and Han-Ping Shi
    Citation: BMC Cancer 2022 22:1080
    Content type: Research Published on:

  44. Radiation therapy is one of the standard methods in the treatment of breast cancer. Radiotherapy-induced dermatitis (RID) is a common complication of radiotherapy (RT) resulting in less tolerance in RT and eve...

    Authors: Mohsen Nabi-Meybodi, Adeleh Sahebnasagh, Zahra Hakimi, Masoud Shabani, Ali Asghar Shakeri and Fatemeh Saghafi
    Citation: BMC Cancer 2022 22:1079
    Content type: Research Published on:

  45. The surgical efficacy and prognostic outcomes of patients with unspecific malignant bone tumors (UMBTs) remain unclear. The study is to address: 1) What are the clinicopathological features and prognostic dete...

    Authors: Shaohui He, Runyi Jiang, Haitao Sun, Jian Yang, Chen Ye, Weibo Liu, Xinghai Yang, Xiaopan Cai and Jianru Xiao
    Citation: BMC Cancer 2022 22:1078
    Content type: Research article Published on:

  46. Various cancer stem cell (CSC) biomarkers and the genes encoding them in head and neck squamous cell carcinoma (HNSCC) have been identified and evaluated. However, the validity of these factors in the prognosi...

    Authors: Su Il Kim, Seon Rang Woo, Joo Kyung Noh, Min Kyeong Lee, Young Chan Lee, Jung Woo Lee, Moonkyoo Kong, Seong-Gyu Ko and Young-Gyu Eun
    Citation: BMC Cancer 2022 22:1077
    Content type: Research Published on:

  47. There is growing interest in the collection and use of patient-reported outcome measures (PROMs) to support clinical decision making in patients with non-small cell lung cancer (NSCLC). However, an overview of...

    Authors: Kuan Liao, Tianxiao Wang, Jake Coomber-Moore, David C Wong, Fabio Gomes, Corinne Faivre-Finn, Matthew Sperrin, Janelle Yorke and Sabine N van der Veer
    Citation: BMC Cancer 2022 22:1076
    Content type: Research Published on:

  48. Microbiome dysbiosis is an important contributing factor in tumor development and thus may be a risk predictor for human malignancies. In the United States, women with Hispanic/Latina (HIS) and African America...

    Authors: Kunwar Somesh Vikramdeo, Shashi Anand, Jennifer Young Pierce, Ajay Pratap Singh, Seema Singh and Santanu Dasgupta
    Citation: BMC Cancer 2022 22:1074
    Content type: Research Published on:

  49. Paclitaxel (PTX), a first-line therapy for triple negative breast cancers (TNBC) induces anti-tumor activity by microtubule stabilization and inhibition of cell division. Its dose-limiting toxicity and short h...

    Authors: Brittany M. Haynes, Kristen Cunningham and Malathy P. V. Shekhar
    Citation: BMC Cancer 2022 22:1073
    Content type: Research Published on:

  50. Although there is broad consensus that only a subset of CIN3 will progress to cancer, there is currently no surefire way to predict which CIN3 will regress. Understanding the natural history of CIN3 is importa...

    Authors: Maria Teresa Bruno, Nazario Cassaro, Gabriele Mazza, Arianna Guaita and Sara Boemi
    Citation: BMC Cancer 2022 22:1072
    Content type: Research Published on:

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