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  1. The GTPase KRas4B has been utilized as a principal target in the development of anticancer drugs. PDE6δ transports KRas4B to the plasma membrane, where it is released to activate various signaling pathways req...

    Authors: Diana Casique-Aguirre, Paola Briseño-Díaz, Ponciano García-Gutiérrez, Claudia Haydée González-de la Rosa, Reyna Sara Quintero-Barceinas, Arturo Rojo-Domínguez, Irene Vergara, Luis Alberto Medina, José Correa-Basurto, Martiniano Bello, Rosaura Hernández-Rivas, María del RocioThompson-Bonilla and Miguel Vargas
    Citation: BMC Cancer 2018 18:1299
    Content type: Research article Published on:

  2. Although tenosynovial giant cell tumor (TGCT) is classified as a benign tumor, it may undergo malignant transformation and metastasize in extremely rare occasions. High aberrant expression of CSF1 has been imp...

    Authors: Robert Nakayama, Jyothi Priya Jagannathan, Nikhil Ramaiya, Marco L. Ferrone, Chandrajit P. Raut, John E. Ready, Jason L. Hornick and Andrew J. Wagner
    Citation: BMC Cancer 2018 18:1296
    Content type: Case report Published on:

  3. MLH1 plays a critical role in maintaining the fidelity of DNA replication, and defects in human MLH1 have been reported. However, the role of MLH1 in endometrial carcinoma has not been fully investigated. Ther...

    Authors: Yue Li, Shihong Zhang, Yuanjian Wang, Jin Peng, Fang Fang and Xingsheng Yang
    Citation: BMC Cancer 2018 18:1294
    Content type: Research article Published on:

  4. The Epstein-Barr virus (EBV) is closely associated with several types of malignancies. EBV is normally present in the latent state in the peripheral blood B cell compartment. The EBV latent-to-lytic switch is ...

    Authors: Pengfei Cao, Meili Zhang, Lujuan Wang, Buqing Sai, Jiuqi Tang, Zhaohui Luo, Cijun Shuai, Liyang Zhang, Zheng Li, Yanjin Wang, Guiyuan Li and Juanjuan Xiang
    Citation: BMC Cancer 2018 18:1293
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:189

  5. Olaratumab is a platelet-derived growth factor receptor-α (PDGFRα)-targeting monoclonal antibody blocking PDGFRα signaling. PDGFRα expression is associated with a more aggressive phenotype and poor ovarian can...

    Authors: William P. McGuire, Richard T. Penson, Martin Gore, Antonio Casado Herraez, Patrick Peterson, Ashwin Shahir and Robert Ilaria Jr
    Citation: BMC Cancer 2018 18:1292
    Content type: Research article Published on:

  6. There are no published studies on the simultaneous effect of extent and location of positive surgical margins (PSMs) on biochemical recurrence (BCR) after robot-assisted laparoscopic prostatectomy (RALP). The ...

    Authors: Gautier Marcq, Aude Michelet, Gerjon Hannink, Jerome Rizk, Jean Sauvain, Arnauld Villers, Mo Saffarini and Charles H. Rochat
    Citation: BMC Cancer 2018 18:1291
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:124

  7. Estrogen receptor (ER) expression is important for treatment selection and prognostication of breast cancer patients. Although the metastases are the main targets of endocrine therapy, ER status is often based...

    Authors: Juan Zhao, Chunxiu Hu, Cheng Wang, Wei Yu, Yinglu Guo, Minghan Shi, Yongjie Shui and Qichun Wei
    Citation: BMC Cancer 2018 18:1290
    Content type: Research article Published on:

  8. Physical fitness and psychosocial function is often reduced in children during or shortly after cancer treatment. This study evaluates the effect of a combined physical exercise and psychosocial intervention o...

    Authors: Katja I. Braam, Elisabeth M. van Dijk-Lokkart, Gertjan J. L. Kaspers, Tim Takken, Jaap Huisman, Laurien M. Buffart, Marc B. Bierings, Johannes H. M. Merks, Marry M. van den Heuvel-Eibrink, Margreet A. Veening and Eline van Dulmen-den Broeder
    Citation: BMC Cancer 2018 18:1289
    Content type: Research article Published on:

  10. Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load (PVL) and HBZ as viral elements and AKT1, BAD,

    Authors: Hanieh Tarokhian, Hossein Rahimi, Arman Mosavat, Abbas Shirdel, Houshang Rafatpanah, Mohammad Mehdi Akbarin, Alireza Bari, Samaneh Ramezani and Seyed Abdolrahim Rezaee
    Citation: BMC Cancer 2018 18:1287
    Content type: Research article Published on:

  11. Ras is a control switch of ERK1/2 pathway, and hyperactivation of Ras-ERK1/2 signaling appears frequently in human cancers. However, the molecular regulation following by Ras-ERK1/2 activation is still unclear...

    Authors: Peng Tian, Yanfei Zhu, Chao Zhang, Xinyu Guo, Peng Zhang and Huanzhou Xue
    Citation: BMC Cancer 2018 18:1286
    Content type: Research article Published on:

    The Retraction Note to this article has been published in BMC Cancer 2021 21:594

  12. The prevalence and distribution of histologically diagnosed breast disease are not well documented in low income countries, Uganda inclusive. Although the greater majority of breast lesions globally are benign...

    Authors: Salvatore Ssemmanda, Eric Katagirya, Phiona Bukirwa, David Alele, Robert Lukande and Samuel Kalungi
    Citation: BMC Cancer 2018 18:1285
    Content type: Research article Published on:

  13. Cisplatin has been widely used for the treatment of cancer and its antitumour activity is attributed to its capacity to form DNA adducts, predominantly at guanine residues, which impede cellular processes such...

    Authors: Ben W. Johnson, Mark W. Burgess, Vincent Murray, Janice R. Aldrich-Wright and Mark D. Temple
    Citation: BMC Cancer 2018 18:1284
    Content type: Research article Published on:

  14. Pancreatic cancer (PC) is a highly aggressive disease, and the lethality of this disease stems from early metastatic dissemination where surgical removal cannot provide a cure. Improvement of the therapeutic o...

    Authors: Sugandha Saxena, Abhilasha Purohit, Michelle L. Varney, Yuri Hayashi and Rakesh K. Singh
    Citation: BMC Cancer 2018 18:1283
    Content type: Research article Published on:

  15. Male breast cancer (MBC) is rare, accounting for only around 1% of all breast cancers. Most MBCs are hormone-driven. Not only the estrogen receptor (ER), but also other steroid hormone receptors, including the...

    Authors: Haruko Takuwa, Wakako Tsuji, Masayuki Shintaku and Fumiaki Yotsumoto
    Citation: BMC Cancer 2018 18:1282
    Content type: Case report Published on:

  16. Palliative care, as a relatively young field within medicine, has increasingly used original research to validate and standardize its practice. In particular, palliative care has been incorporated into oncolog...

    Authors: Corbin Eule, Nizar Bhulani, Elizabeth Paulk, Ramona Rhodes and Muhammad Shaalan Beg
    Citation: BMC Cancer 2018 18:1281
    Content type: Research article Published on:

  18. We wished to evaluate the efficacy and safety of liposomal paclitaxel and docetaxel for induction chemotherapy (IC) for nasopharyngeal carcinoma (NPC).

    Authors: Sai-Lan Liu, Xue-Song Sun, Xiao-Yun Li, Qiu-Yan Chen, Huan-Xin Lin, Yue-Feng Wen, Shan-Shan Guo, Li-Ting Liu, Hao-Jun Xie, Qing-Nan Tang, Yu-Jing Liang, Jin-Jie Yan, Chao Lin, Zhen-Chong Yang, Lin-Quan Tang, Ling Guo…
    Citation: BMC Cancer 2018 18:1279
    Content type: Research article Published on:

  19. Regulatory T cells (Treg) suppress cytotoxic T cell anti-tumoral immune responses and thereby promote tumor progression. Prevention of intratumoral Treg accumulation by inhibition of their migration to the tum...

    Authors: Benjamin Kuehnemuth, Ignazio Piseddu, Gabriela M. Wiedemann, Michael Lauseker, Christina Kuhn, Simone Hofmann, Elisa Schmoeckel, Stefan Endres, Doris Mayr, Udo Jeschke and David Anz
    Citation: BMC Cancer 2018 18:1278
    Content type: Research article Published on:

  20. Ventana ALK (D5F3) screening of anaplastic lymphoma kinase (ALK) gene rearrangement in tissue specimens has been approved by US FDA (Food and Drug Administration) to select treatment for non–small-cell lung ca...

    Authors: Hui Qin Guo, Jia Jia, Lin Lin Zhao, Huan Zhao, Cong Wang, Yue Sun, Jian Ming Ying, Lei Guo, Jian Cao and Zhi Hui Zhang
    Citation: BMC Cancer 2018 18:1277
    Content type: Research article Published on:

  21. The role of pretreatment Epstein-Barr virus DNA (pre-DNA) for individualized induction chemotherapy (IC) in locoregionally advanced nasopharyngeal carcinoma (LA-NPC) still remains unknown. We aimed to address ...

    Authors: Jian Zhang, Hao Peng, Wen-Fei Li, Yuan Zhang, Li-Zhi Liu, Li Tian, Ai-Hua Lin, Ying Sun and Jun Ma
    Citation: BMC Cancer 2018 18:1276
    Content type: Research article Published on:

  22. Few epidemiologic findings are as well established as the association between smoking and lung cancer. It is therefore somewhat surprising that there is not yet a clear consensus about the exposure-response re...

    Authors: T. Remen, J. Pintos, M. Abrahamowicz and J. Siemiatycki
    Citation: BMC Cancer 2018 18:1275
    Content type: Research article Published on:

  23. HDIL-2 is approved for advanced melanoma based on its durable antitumor activity. MAGE-A3 cancer immunotherapeutic (MAGE-A3 CI) is a recombinant MAGE-A3 protein combined with an immunostimulant adjuvant system...

    Authors: Jennifer L. McQuade, Jade Homsi, Carlos A. Torres-Cabala, Roland Bassett, Rashmi Murthy Popuri, Marihella L. James, Luis M. Vence and Wen-Jen Hwu
    Citation: BMC Cancer 2018 18:1274
    Content type: Research article Published on:

  24. Breast cancer is the most common malignancy in women affecting one out of eight females throughout their lives. Autotaxin (ATX) is upregulated in breast cancer which results in increased lysophosphatidic acid ...

    Authors: Rafael Schmid, Katharina Wolf, Jan W. Robering, Selina Strauß, Pamela L. Strissel, Reiner Strick, Matthias Rübner, Peter A. Fasching, Raymund E. Horch, Andreas E. Kremer, Anja M. Boos and Annika Weigand
    Citation: BMC Cancer 2018 18:1273
    Content type: Research article Published on:

  26. In the absence of head-to-head trials comparing axitinib with cabozantinib or everolimus, the aim of this study was to conduct an indirect comparison of their relative efficacy in patients with metastatic rena...

    Authors: Irina Proskorovsky, Agnes Benedict, Sylvie Negrier, Danielle Bargo, Rickard Sandin, Krishnan Ramaswamy, Jigar Desai, Joseph C. Cappelleri and James Larkin
    Citation: BMC Cancer 2018 18:1271
    Content type: Research article Published on:

  27. Gastric cancer (GC) ranks the second in mortality rate among all cancers. Metastases account for most of the deaths in GC patients. Yet our understanding of GC and its metastasis mechanism is still very limited.

    Authors: Jie Zhang, Weiqing Qiu, Hua Liu, Changlin Qian, Dujuan Liu, Hailong Wang, Ni Hu, Y. Tom Tang, Jianhua Sun and Zhiyong Shen
    Citation: BMC Cancer 2018 18:1270
    Content type: Research article Published on:

  28. Definite prognostic clinical factors of benefit for decitabine-based induction chemotherapy in elderly patients newly diagnosed with acute myeloid leukaemia (AML) are not identified. This study was designed to...

    Authors: Jiayu Huang, Huihui Zhao, Ming Hong, Han Zhu, Yu Zhu, Yun Lian, Shan Li, Jianyong Li and Sixuan Qian
    Citation: BMC Cancer 2018 18:1269
    Content type: Research article Published on:

  29. We previously demonstrated that knockdown of delta-5-desaturase via siRNA transfection together with dihomo-γ-linolenic acid supplementation inhibited colon cancer cell growth and migration, by promoting the p...

    Authors: Yi Xu, Xiaoyu Yang, Di Gao, Liu Yang, Keith Miskimins and Steven Y. Qian
    Citation: BMC Cancer 2018 18:1268
    Content type: Research article Published on:

  30. The purpose of this study was to evaluate the clinical impact of oxaliplatin, leucovorin, and 5-fluorouracil (FOLFOX-4) chemotherapy in terms of the response rate, progression-free/overall survival (PFS/OS) an...

    Authors: Vincenza Conteduca, Giorgia Gurioli, Lorena Rossi, Emanuela Scarpi, Cristian Lolli, Giuseppe Schepisi, Alberto Farolfi, Delia De Lisi, Valentina Gallà, Salvatore Luca Burgio, Cecilia Menna, Andrea Amadori, Lorena Losi, Dino Amadori, Maria Paola Costi and Ugo De Giorgi
    Citation: BMC Cancer 2018 18:1267
    Content type: Research article Published on:

  31. Clinical assays for the assessment of the human epidermal growth factor receptor-2 (HER2) status in breast cancer include immunohistochemistry (IHC) and in situ hybridization (ISH), both of which have limitati...

    Authors: David G. Hicks, Brandon Buscaglia, Hideki Goda, Loralee McMahon, Takako Natori, Bradley Turner, Armen Soukiazian, Hisatake Okada and Yasushi Nakano
    Citation: BMC Cancer 2018 18:1266
    Content type: Technical advance Published on:

  32. Broad copy number aberrations (BCNAs) represent a common form of genome instability in colorectal cancer (CRC). CRCs show large variations in their level of aneuploidy: microsatellite-instable (MSI) tumors are...

    Authors: Vincenza Barresi, Giacomo Cinnirella, Giovanna Valenti, Giorgia Spampinato, Nicolò Musso, Sergio Castorina and Daniele F. Condorelli
    Citation: BMC Cancer 2018 18:1265
    Content type: Research article Published on:

  33. Obesity is associated with oxidative stress, a major factor in carcinogenesis, and with high leptin concentration. The aim of this study was to determine the effects of leptin on the antioxidant response in th...

    Authors: Sinda Mahbouli, Jérémie Talvas, Audrey der Vartanian, Sophie Ortega, Stéphanie Rougé, Marie-Paule Vasson and Adrien Rossary
    Citation: BMC Cancer 2018 18:1264
    Content type: Research article Published on:

  34. Glucose regulated protein 78 (GRP78) is a resident chaperone of the endoplasmic reticulum and a master regulator of the unfolded protein response under physiological and pathological cell stress conditions. GR...

    Authors: Christopher N. Cultrara, Stephen D. Kozuch, Poornema Ramasundaram, Claudia J. Heller, Sunil Shah, Adah E. Beck, David Sabatino and Jenny Zilberberg
    Citation: BMC Cancer 2018 18:1263
    Content type: Research article Published on:

  35. Ocular melanoma is a rare but often deadly malignancy that arises in the uvea (commonest primary site), conjunctiva or the orbit. Primary orbital melanoma (POM) is exceedingly rare, with approximately 60 cases...

    Authors: Anna M. Rose, Rong Luo, Utsav K. Radia, Helen Kalirai, Sophie Thornton, Philip J. Luthert, Channa N. Jayasena, David H. Verity, Sarah E. Coupland and Geoffrey E. Rose
    Citation: BMC Cancer 2018 18:1262
    Content type: Research article Published on:

  36. The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) are associated with poor prognoses in patients with gastric cancer; however, few studies have focused on the dynamic changes ...

    Authors: Mikito Mori, Kiyohiko Shuto, Chihiro Kosugi, Kazuo Narushima, Hideki Hayashi, Hisahiro Matsubara and Keiji Koda
    Citation: BMC Cancer 2018 18:1261
    Content type: Research article Published on:

  37. This study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive factors for VTE were a...

    Authors: Jung Sun Kim, Eun Joo Kang, Dae Sik Kim, Yoon Ji Choi, Suk Young Lee, Hong Jun Kim, Hee Yeon Seo and Jun Suk Kim
    Citation: BMC Cancer 2018 18:1260
    Content type: Research article Published on:

  38. Genetic alterations in pediatric primary brain tumors can be used as diagnostic and prognostic markers and are the basis for the development of new target therapies that, ideally, would be associated with lowe...

    Authors: Laura Frazão, Maria do Carmo Martins, Vasco Moura Nunes, José Pimentel, Claudia Faria, José Miguéns, Amets Sagarribay, Mário Matos, Duarte Salgado, Sofia Nunes, Manuela Mafra and Lúcia Roque
    Citation: BMC Cancer 2018 18:1259
    Content type: Research article Published on:

  39. Kaposi’s sarcoma (KS) is a multifocal angioproliferative tumor involving blood and lymphatic vessels, caused by Human Herpes Virus-8 (HHV-8). KS is an important AIDS-defining tumor with high prevalence in Sub-...

    Authors: George P. Semango, Renard M. Charles, Consolata I. Swai, Alex Mremi, Patrick Amsi, Tolbert Sonda, Elichilia R. Shao, Daudi R. Mavura, Leo A. B. Joosten, Elingarami Sauli and Mramba Nyindo
    Citation: BMC Cancer 2018 18:1258
    Content type: Research article Published on:

  40. FGD4 (Frabin) is an F-actin binding protein with GTP/GDP exchange activity specific for CDC42. It is involved in reorganization of the actin cytoskeleton, which requires both actin binding and CDC42 activating...

    Authors: Alexia Bossan, Richard Ottman, Thomas Andl, Md Faqrul Hasan, Nupam Mahajan, Domenico Coppola and Ratna Chakrabarti
    Citation: BMC Cancer 2018 18:1257
    Content type: Research article Published on:

  42. The secretion of soluble factors enables communication between tumour cells and the surrounding microenvironment and plays an important role in oncogenesis. Pancreatic ductal adenocarcinoma (PDAC) is character...

    Authors: Taoufik Nedjadi, Anthony Evans, Adnan Sheikh, Lawrence Barerra, Suliman Al-Ghamdi, Lucy Oldfield, W. Greenhalf, John P. Neoptolemos and Eithne Costello
    Citation: BMC Cancer 2018 18:1255
    Content type: Research article Published on:

  43. Salivary gland cancers are not sensitive to conventional radiotherapy or chemotherapy regimens. Therefore, the development of a new treatment strategy is of critical importance for improving the prognosis. We ...

    Authors: Yuji Makita, Naoki Kunii, Daiju Sakurai, Fumie Ihara, Shinichiro Motohashi, Akane Suzuki, Toshinori Nakayama and Yoshitaka Okamoto
    Citation: BMC Cancer 2018 18:1254
    Content type: Research article Published on:

  44. Patients with locally advanced rectal cancer (LARC) achieving a pathological complete response (pCR) to neoadjuvant treatment usually have a good prognosis, but only accounted for less than 20%.

    Authors: Zhenyu Lin, Junli Liu, Li Peng, Dejun Zhang, Ming Jin, Jing Wang, Jun Xue, Hongli Liu and Tao Zhang
    Citation: BMC Cancer 2018 18:1253
    Content type: Case report Published on:

  46. Well-designed clinical trials are of great importance in validating novel treatments and ensuring an evidence-based approach for sarcoma. This study aimed to provide a comprehensive landscape of the characteri...

    Authors: Y Que, W Xiao, BS Xu, XZ Wen, DS Weng and X Zhang
    Citation: BMC Cancer 2018 18:1251
    Content type: Research article Published on:

  47. Before the targeted therapies era, cytotoxic chemotherapy (CCT) was an option for advanced hepatocellular carcinoma (HCC), even with the lack of supporting evidence. Since the last decade, sorafenib has been e...

    Authors: Leonardo Gomes da Fonseca, Guilherme Nader Marta, Maria Ignez Freitas Melro Braghiroli, Aline Lopes Chagas, Flair Jose Carrilho, Paulo Marcelo Hoff and Jorge Sabbaga
    Citation: BMC Cancer 2018 18:1250
    Content type: Research article Published on:

  48. Thymomas are typically slow-growing tumors and AB type thymomas are considered no/low risk tumors with a better prognosis. Extra-thoracic metastases are extremely rare. To the best of our knowledge, no patient...

    Authors: Yuichi Aoki, Atsushi Miki, Tomoyuki Nakano, Hideki Sasanuma, Yasunaru Sakuma, Hisanaga Horie, Yoshinori Hosoya, Noriyoshi Fukushima, Alan Kawarai Lefor and Naohiro Sata
    Citation: BMC Cancer 2018 18:1249
    Content type: Case report Published on:

  49. Cancer patients’ survival time has obviously improved, with the development of systemic treatment techniques. However, the probability of metastases to the vertebrae has also been increased which makes some ad...

    Authors: Xiong-gang Yang, Deng-xing Lun, Yong-cheng Hu, Yong-heng Liu, Feng Wang, Jiang-tao Feng, Kun-chi Hua, Li Yang, Hao Zhang, Ming-you Xu and Hao-ran Zhang
    Citation: BMC Cancer 2018 18:1248
    Content type: Research article Published on:

  50. Uterine sarcomas consist a heterogeneous group of mesenchymal gynecological malignancies with unclear therapeutic recommendations and unspecific but poor prognosis, since they usually metastasize and tend to r...

    Authors: Anastasios Kyriazoglou, Michael Liontos, Dimitrios C Ziogas, Flora Zagouri, Kostantinos Koutsoukos, Giorgos Tsironis, Anna Tsiara, Maria Kaparelou, Roubini Zakopoulou, Nikolaos Thomakos, Dimitrios Haidopoulos, Irene Papaspyrou, Alexandros Rodolakis, Aristotelis Bamias and Meletios Athanasios Dimopoulos
    Citation: BMC Cancer 2018 18:1247
    Content type: Research article Published on:

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