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  1. Aromatase inhibitors (AI) are frequently used to treat hormone-receptor-positive breast cancer, but they have multiple adverse effects (e.g., osteoporosis, arthralgia), resulting in premature therapy discontin...

    Authors: Eliana V. Carraça, Bruno Rodrigues, Sofia Franco, Inês Nobre, Flávio Jerónimo, Vítor Ilharco, Fernanda Gabriel, Leonor Ribeiro, António L. Palmeira and Marlene N. Silva
    Citation: BMC Cancer 2023 23:632
    Content type: Study Protocol Published on:

  2. Multiple myeloma is a heterogeneous disorder and the intratumor genetic heterogeneity contributes to emergency of drug resistance. Dexamethasone has been used clinically for decades for MM. Nevertheless, their...

    Authors: Yuyue Ren, Yijun Liu, Wanting He, Weiwei Zhao, Jiaqi Pan, Haiyan Gao, Yuying Li, Ying Zhang and Wei Wang
    Citation: BMC Cancer 2023 23:630
    Content type: Research Published on:

  3. To include the patient perspective in the assessment of adverse events in oncology, a patient-reported outcomes (PRO) version of the Common Terminology Criteria for Adverse Events (CTCAE) was developed by the ...

    Authors: Maximilian Günther, Leopold Hentschel, Markus Schuler, Theresa Müller, Katharina Schütte, Yon-Dschun Ko, Ingo Schmidt-Wolf and Ulrich Jaehde
    Citation: BMC Cancer 2023 23:629
    Content type: Research Published on:

  5. CXC-chemokine receptor 2 (CXCR2) expression was found to be down-regulated on circulating monocytes of cancer patients. Here, we analyze the percentage of CD14+CXCR2+ monocyte subsets in hepatocellular carcinoma ...

    Authors: Chong Zhong Liu, Xing Bao Liu, Jun Sun, Chao Qun Yu, Jing Chun Yao, Zhong Liu and Jing Cheng Hao
    Citation: BMC Cancer 2023 23:626
    Content type: Research Published on:

  6. Adjuvant endocrine treatment is essential for treating luminal subtypes of breast cancer, which constitute 75% of all breast malignancies. However, the detrimental side effects of treatment make it difficult f...

    Authors: Finn Magnus Eliassen, Vibeke Blåfjelldal, Thomas Helland, Cathrine Fonnesbech Hjorth, Kari Hølland, Lise Lode, Bjørn-Erik Bertelsen, Emiel A. M. Janssen, Gunnar Mellgren, Jan Terje Kvaløy, Håvard Søiland and Tone Hoel Lende
    Citation: BMC Cancer 2023 23:625
    Content type: Research Published on:

  7. Locally advanced pancreatic ductal adenocarcinoma (PDAC), accounting for about 30% of PDAC patients, is difficult to cure by radical resection or systemic chemotherapy alone. A multidisciplinary strategy is re...

    Authors: Osamu Shimomura, Masato Endo, Hirokazu Makishima, Takeshi Yamada, Shinji Hashimoto, Haruko Numajiri, Yoshihiro Miyazaki, Manami Doi, Kinji Furuya, Kazuhiro Takahashi, Toshikazu Moriwaki, Naoyuki Hasegawa, Yoshiyuki Yamamoto, Yusuke Niisato, Mariko Kobayashi, Masashi Mizumoto…
    Citation: BMC Cancer 2023 23:624
    Content type: Study protocol Published on:

  8. Cancer is highly prevalent worldwide. Family resilience is a positive variable that helps families burdened by advanced cancer to cope effectively. This study aimed to describe the family resilience of advance...

    Authors: Panpan Cui, Jiaoxia Shi, Shifeng Li, Mikiyas Amare Getu, Ruibo Wang and Changying Chen
    Citation: BMC Cancer 2023 23:623
    Content type: Research Published on:

  9. Lymph node metastasis (LNM) is an important factor affecting endometrial cancer (EC) prognosis. Current controversy exists as to how to accurately assess the risk of lymphatic metastasis. Metabolic syndrome ha...

    Authors: Xuan Feng, Xing Chen Li, Xiao Yang, Yuan Cheng, Yang Yang Dong, Jing Yuan Wang, Jing Yi Zhou and Jian Liu Wang
    Citation: BMC Cancer 2023 23:622
    Content type: Research Published on:

  10. Sensitive and reproducible detection of residual disease after treatment is a major challenge for patients with locally advanced head and neck cancer. Indeed, the current imaging techniques are not always reli...

    Authors: Angeline Ginzac, Marie-Céleste Ferreira, Anne Cayre, Clément Bouvet, Julian Biau, Ioana Molnar, Nicolas Saroul, Nathalie Pham-Dang, Xavier Durando and Maureen Bernadach
    Citation: BMC Cancer 2023 23:621
    Content type: Study Protocol Published on:

  11. Metabolic derangements and systemic inflammation are related to the progression of colorectal cancer (CRC) and the prognoses of these patients. The survival of stage II and III CRC patients existed considerabl...

    Authors: Jinming Fu, Fenqi Du, Tian Tian, Hao Huang, Lei Zhang, Dapeng Li, Yupeng Liu, Ding Zhang, Lijing Gao, Ting Zheng, Yanlong Liu and Yashuang Zhao
    Citation: BMC Cancer 2023 23:620
    Content type: Research Published on:

  13. Gene fusions are important cancer drivers in pediatric cancer and their accurate detection is essential for diagnosis and treatment. Clinical decision-making requires high confidence and precision of detection...

    Authors: Ianthe A. E. M. van Belzen, Casey Cai, Marc van Tuil, Shashi Badloe, Eric Strengman, Alex Janse, Eugène T. P. Verwiel, Douwe F. M. van der Leest, Lennart Kester, Jan J. Molenaar, Jules Meijerink, Jarno Drost, Weng Chuan Peng, Hindrik H. D. Kerstens, Bastiaan B. J. Tops, Frank C. P. Holstege…
    Citation: BMC Cancer 2023 23:618
    Content type: Research article Published on:

  14. The prognosis of patients with colorectal cancer is related to early detection. However, commonly used screening markers lack sensitivity and specificity. In this study, we identified diagnostic methylation si...

    Authors: Zhen Ye, Guangle Song, Jianwei Liang, Shuying Yi, Yuqi Gao and Hanming Jiang
    Citation: BMC Cancer 2023 23:617
    Content type: Research Published on:

  15. To investigate the relationship among 18 heavy metals, microsatellite instability (MSI) status, ERCC1, XRCC1 (rs25487), BRAF V600E and 5 tumor markers and their role in the development of colorectal cancer (CRC).

    Authors: Yongsheng Li, Jingwei Lou, Shaozhong Hong, Dengfeng Hou, Yandong Lv, Zhiqiang Guo, Kai Wang, Yue Xu, Yufeng Zhai and Hongzhou Liu
    Citation: BMC Cancer 2023 23:616
    Content type: Research Published on:

  16. Insulin resistance is an overlapping risk factor for both heart and breast cancer, while its interaction with cardiotoxicity in breast cancer (BC) patients is not clear. This study investigated the impact of i...

    Authors: Yunjing Shi, Zeping Qiu, Jing Yu, Zhuojin Li, Sha Hua, Yanjia Chen, Xiaosong Chen, Kunwei Shen and Wei Jin
    Citation: BMC Cancer 2023 23:615
    Content type: Research Published on:

  17. Small extracellular vesicles (sEVs) have great potential as new biomarkers in liquid biopsy. However, due to the limitations of sEVs extraction and component analysis procedures, further clinical applications ...

    Authors: Yifan Sun, Miao Li, Xiaoshan Zhang, Dongjie Xu, Jie Wu, Xinrui Gu, Adeel Khan, Han Shen and Zhiyang Li
    Citation: BMC Cancer 2023 23:614
    Content type: Research Published on:

  18. Ovarian clear cell carcinomas (OCCCs) are rare, aggressive and chemoresistant tumors. Geographical and ethnic differences in the incidence of OCCC have been reported with a higher incidence in Asiatic countrie...

    Authors: Mariana de Paiva Batista, Martín Roffé, Ignacio Romero, José Antonio López-Guerrero, Carmen Illueca, Raquel Lopez, Alexandre André Balieiro Anastácio da Costa, Louise De Brot, Juan Pablo Molina, Laura Barboza, Fernanda Maris Peria, Fernando Chaud, Ana Silvia Gouvêa Yamada, Andres Poveda and Eduardo Magalhães Rego
    Citation: BMC Cancer 2023 23:613
    Content type: Research Published on:

  22. Even though chemotherapy-induced nausea and vomiting (CINV) can be well controlled in the acute phase, the incidence of delayed CINV remains high. In this study, we intend to investigate whether prolonged use ...

    Authors: Ai Gao, Shasha Guan, Yinjuan Sun, Lingling Wang, Fanlu Meng, Xia Liu, Liyan Gu, Guo Li, Diansheng Zhong and Linlin Zhang
    Citation: BMC Cancer 2023 23:609
    Content type: Research Published on:

  23. To assess the clinical characteristics and the risk factors related to the unfavorable prognosis of endometrioid ovarian carcinoma (EOVC) based on data from the Surveillance, Epidemiology, and End Results (SEE...

    Authors: Shuangfeng Chen, Huaiwu Lu, Shan Jiang, Min Li, Haiyan Weng, Jing Zhu, Tianjiao Zhang, Yingying Wang, Weidong Zhao, Dabao Wu, Zhen Shen, Zhenye Yang and Ying Zhou
    Citation: BMC Cancer 2023 23:608
    Content type: Research Published on:

  24. Single nucleotide polymorphism (SNP) is a genetic variation that occurs when a single nucleotide base in the DNA sequence varies between individuals and is present in at least 1% of the population. Genetic var...

    Authors: Ming-Ju Hsieh, Yu-Sheng Lo, Yun-Jung Tsai, Hsin-Yu Ho, Chia-Chieh Lin, Yi-Ching Chuang, Shu-Hui Lin and Mu-Kuan Chen
    Citation: BMC Cancer 2023 23:607
    Content type: Research Published on:

  25. Extending adjuvant endocrine therapy (ET) beyond the standard 5 years offers added protection against late breast cancer recurrences in women with early-stage hormone receptor-positive (HR +) breast cancer. Li...

    Authors: Julia Foldi, Anastasia Tsagianni, Max Salganik, Catherine A. Schnabel, Adam Brufsky, G. J. van Londen, Lajos Pusztai and Tara Sanft
    Citation: BMC Cancer 2023 23:606
    Content type: Research article Published on:

  26. Urothelial bladder cancer is most frequently diagnosed at the non-muscle-invasive stage (NMIBC). However, recurrences and interventions for intermediate and high-risk NMIBC patients impact the quality of life....

    Authors: Iliana K. Kerzeli, Alexandros Kostakis, Polat Türker, Per-Uno Malmström, Tammer Hemdan, Artur Mezheyeuski, Douglas G. Ward, Richard T. Bryan, Ulrika Segersten, Martin Lord and Sara M. Mangsbo
    Citation: BMC Cancer 2023 23:605
    Content type: Research Published on:

  27. Aspartoacylase (ASPA) is a gene that plays an important role in the metabolic reprogramming of cancer. However, the clinical relevance of ASPA in gastric cancer (GC) has not been demonstrated.

    Authors: Yalin Han, Xuning Wang, Maolin Xu, Zhipeng Teng, Rui Qin, Guodong Tan, Peng Li, Peng Sun, Hongyi Liu, Li Chen and Baoqing Jia
    Citation: BMC Cancer 2023 23:604
    Content type: Research Published on:

  28. The landscape of non-small cell lung cancer (NSCLC) therapy is rapidly changing. This analysis aimed to understand patient characteristics, diagnosis and treatment patterns in patients with metastatic NSCLC (m...

    Authors: Hollie Bailey, Adam Lee, Laura Eccles, Yong Yuan, Helen Burlison, Cameron Forshaw and Nebibe Varol
    Citation: BMC Cancer 2023 23:603
    Content type: Research Published on:

  29. The discovery of new anti-melanoma drugs with low side effect is urgently required in the clinic. Recent studies showed that morusin, a flavonoid compound isolated from the root bark of Morus Alba, has the pot...

    Authors: Wei Liu, Yacong Ji, Feng Wang, Chongyang Li, Shaomin Shi, Ruochen Liu, Qian Li, Leiyang Guo, Yaling Liu and Hongjuan Cui
    Citation: BMC Cancer 2023 23:602
    Content type: Research Published on:

  30. Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by challenging early diagnosis and poor prognosis. It is believed that coagulation has an impact on the tumor microenvironment of PDAC. The...

    Authors: Di Wang, Song-ping Cui, Qing Chen, Zhang-yong Ren, Shao-cheng Lyu, Xin Zhao and Ren Lang
    Citation: BMC Cancer 2023 23:601
    Content type: Research Published on:

  31. An assessment is being conducted to determine the safety and effectiveness of using Cone-beam computed tomography (CBCT)-guided transcatheter arterial chemoembolization (TACE) and microwave ablation (MWA) sequ...

    Authors: Zhaonan Li, Kaihao Xu, Xueliang Zhou, Dechao Jiao and Xinwei Han
    Citation: BMC Cancer 2023 23:600
    Content type: Research Published on:

  32. Dihydropyrimidinase-like 3 (DPYSL3) is a cytosolic phosphoprotein expressed in the nervous system and is crucial for neurogenesis. A previous study showed that increased DPYSL3 expression promotes tumour aggre...

    Authors: Peir-In Liang, Hong-Yue Lai, Ti-Chun Chan, Wei-Ming Li, Chung-Hsi Hsing, Steven K. Huang, Kun-Lin Hsieh, Wen-Hsin Tseng, Tzu-Ju Chen, Wan-Shan Li, Huan-Da Chen, Yu-Hsuan Kuo and Chien-Feng Li
    Citation: BMC Cancer 2023 23:599
    Content type: Research Published on:

  33. Over past decades, epidemiological patterns of liver cancer (LC) have changed dramatically. The Global Burden of Disease (GBD) study provides an opportunity for tracking the progress in cancer control with its...

    Authors: Yongzhi Li, Zejin Ou, Danfeng Yu, Huan He, Liting Zheng, Jiaqi Chen, Caiyun Chen, Hushen Xiong and Qing Chen
    Citation: BMC Cancer 2023 23:598
    Content type: Research Published on:

  34. The nutritional status of cancer patients is a crucial factor in determining their prognosis. The objective of this study was to investigate and compare the prognostic value of pretreatment nutrition-related i...

    Authors: Jianjian Qiu, Jun Yang, Yilin Yu, Zhiping Wang, Hancui Lin, Dongmei Ke, Hongying Zheng, Jiancheng Li and Qiwei Yao
    Citation: BMC Cancer 2023 23:597
    Content type: Research Published on:

  35. Glioma is the most common malignant primary brain tumor and is characterized by a poor prognosis and limited therapeutic options. ISG20 expression is induced by interferons or double-stranded RNA and is associ...

    Authors: Yaojun Peng, Hongyu Liu, Qiyan Wu, Lingxiong Wang, Yanju Yu, Fan Yin, Cong Feng, Xuewen Ren, Tianyi Liu, Ling Chen and Haiyan Zhu
    Citation: BMC Cancer 2023 23:596
    Content type: Research Published on:

  36. Although the incidence of late-onset colorectal cancer (LOCRC) has decreased, the incidence of early-onset colorectal cancer (EOCRC) is still rising dramatically. Heterogeneity in the genomic, biological, and ...

    Authors: Meijuan Xiang, Yuan Gao, Yue Zhou, Muqing Wang and Xueqing Yao
    Citation: BMC Cancer 2023 23:595
    Content type: Research Published on:

  37. The detailed molecular mechanism between type 2 diabetes mellitus (T2DM) and colorectal cancer (CRC) is still uncertain. Bone morphogenetic protein 4 (BMP4) dysregulation is implicated in T2DM and CRC, respect...

    Authors: Bingwei Ma, Xingchun Wang, Hui Ren, Yingying Li, Haijiao Zhang, Muqing Yang and Jiyu Li
    Citation: BMC Cancer 2023 23:594
    Content type: Research Published on:

  38. The lack of effective and accurate predictive indicators remains a major bottleneck for the improvement of the prognosis of patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Hepatit...

    Authors: Ming-Da Wang, Hao Xiang, Tian-Yu Hong, Abudurexiti Mierxiati, Fei-Hu Yan, Ling Zhang and Chao Wang
    Citation: BMC Cancer 2023 23:593
    Content type: Research Published on:

  39. Chemoradiotherapy (CRT) remains the standard treatment for locally advanced rectal cancer (LARC). This phase 2 clinical trial was designed to evaluate the efficacy and safety of neoadjuvant triplet chemotherap...

    Authors: Wen Zhang, Haitao Zhou, Jun Jiang, Yuelu Zhu, Shuangmei Zou, Liming Jiang, Yuan Tang, Jianwei Liang, Yongkun Sun, Zhichao Jiang, Wang Qu, Ying Li and Aiping Zhou
    Citation: BMC Cancer 2023 23:592
    Content type: Research Published on:

  40. Cancer-associated fibroblasts (CAFs) have significant tumor regulatory functions, and CAFs-derived exosomes (CAFs-Exo) released from CAFs play an important role in the progression of oral squamous cell carcino...

    Authors: Wei-Zhou Wang, Xue Cao, Li Bian, Yue Gao, Ming Yu, Yi-Ting Li, Jian-Guo Xu, Yang-Hao Wang, He-Feng Yang, Ding-Yun You and Yong-Wen He
    Citation: BMC Cancer 2023 23:591
    Content type: Research Published on:

  41. Women with inherited mutations in the BRCA1 or BRCA2 genes have increased lifetime risks for developing breast and/or ovarian cancer and may develop these cancers around the age of 30 years. Therefore, prevention...

    Authors: Lára R. Hallsson, Gaby Sroczynski, Jutta Engel and Uwe Siebert
    Citation: BMC Cancer 2023 23:590
    Content type: Research Published on:

  42. Solute carrier family 25 member 32 (SLC25A32) is an important member of SLC25A family and plays a role in folate transport metabolism. However, the mechanism and function of SLC25A32 in the progression of huma...

    Authors: Zhiwei Xue, Jiwei Wang, Zide Wang, Junzhi Liu, Jiangli Zhao, Xuchen Liu, Yan Zhang, Guowei Liu, Zhimin Zhao, Wenjie Li, Qing Zhang, Xingang Li, Bin Huang and Xinyu Wang
    Citation: BMC Cancer 2023 23:589
    Content type: Research Published on:

  45. Histone acetyltransferases (HATs) of the MYST family are associated with a variety of human cancers. However, the relationship between MYST HATs and their clinical significance in kidney renal clear cell carci...

    Authors: Fan Liang, Xiangke Li, Xiaoman Shen, Runlei Yang and Chuan Chen
    Citation: BMC Cancer 2023 23:586
    Content type: Research Published on:

  46. Although polypharmacy has been described among cancer patients, very few studies have focused on those with lung cancer. We aimed to assess whether polypharmacy and comorbidity have an impact on systemic paren...

    Authors: Hélène Pluchart, Sébastien Bailly, Sébastien Chanoine, Denis Moro-Sibilot, Pierrick Bedouch and Anne-Claire Toffart
    Citation: BMC Cancer 2023 23:585
    Content type: Research Published on:

  48. Breast cancer is a malignant tumour that seriously threatens women’s life and health and exhibits high inter-individual heterogeneity, emphasising the need for more in-depth research on its pathogenesis. While...

    Authors: Qinghua Huang, Jianlan Mo, Huawei Yang, Yinan Ji, Rong Huang, Yan Liu and You Pan
    Citation: BMC Cancer 2023 23:583
    Content type: Research Published on:

  50. Treatment decisions in prostate cancer (PCa) rely on disease stratification between localised and metastatic stages, but current imaging staging technologies are not sensitive to micro-metastatic disease. Circ...

    Authors: Tarek Al-Hammouri, Ricardo Almeida-Magana, Rachel Lawrence, Tom Duffy, Laura White, Edwina Burke, Sakunthala Kudahetti, Justin Collins, Prabhakar Rajan, Daniel Berney, Rhian Gabe, Greg Shaw and Yong-Jie Lu
    Citation: BMC Cancer 2023 23:581
    Content type: Study Protocol Published on:

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