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  1. Patients with triple-negative breast cancer (TNBC) are generally younger and more likely to experience disease recurrence and have the shortest survival among all breast cancer patients. Recently, neoadjuvant ...

    Authors: Javier Cortes, Amin Haiderali, Min Huang, Wilbur Pan, Peter Schmid, Katherine G. Akers, Julie E. Park, Andrew M. Frederickson, Peter A. Fasching and Joyce O’Shaughnessy
    Citation: BMC Cancer 2023 23:792
    Content type: Research Published on:

  2. The optimal first-line immunotherapy regimen for advanced non-squamous non-small cell lung cancer (NS-NSCLC) patients with programmed cell death ligand 1 (PD-L1) expression ≥ 50% remains unclear. Our aim is to...

    Authors: Wei Chen, Jiayi Chen, Lin Zhang, Sheng Cheng and Junxian Yu
    Citation: BMC Cancer 2023 23:791
    Content type: Research Published on:

  3. To improve prediction, the AJCC staging system was revised to be consistent with upfront surgery (UFS) and neoadjuvant therapy (NAT) for PDAC.

    Authors: Lingyu Zhu, Shuo Shen, Huan Wang, Guoxiao Zhang, Xiaoyi Yin, Xiaohan Shi, Suizhi Gao, Jiawei Han, Yiwei Ren, Jian Wang, Hui Jiang, Shiwei Guo and Gang Jin
    Citation: BMC Cancer 2023 23:790
    Content type: Research Published on:

  4. This study aimed to evaluate the potential of exosomes from cancer cells to predict chemoresistance in pancreatic cancer (PC) and explore the molecular mechanisms through RNA-sequencing and mass spectrometry. ...

    Authors: Yuhan Yang, Haitao Gu, Kundong Zhang, Zengya Guo, Xiaofeng Wang, Qingyun Wei, Ling Weng, Xuan Han, Yan Lv, Meng Cao, Peng Cao, Chen Huang and Zhengjun Qiu
    Citation: BMC Cancer 2023 23:789
    Content type: Research Published on:

  5. Clinical trials have shown that anti-PD1 therapy, either as a monotherapy or in combination, is effective and well-tolerated in patients with recurrent or unresectable hepatocellular carcinoma (HCC). In this s...

    Authors: Xindan Kang, Jing Wang, Xue Kang and Li Bai
    Citation: BMC Cancer 2023 23:787
    Content type: Research Published on:

  6. There is a need for biomarkers that improve accuracy compared with current demographic risk indices to detect individuals at the highest lung cancer risk. Improved risk determination will enable more effective...

    Authors: Daniel J. Craig, Erin L. Crawford, Heidi Chen, Eric L. Grogan, Steven A. Deppen, Thomas Morrison, Sanja L. Antic, Pierre P. Massion and James C. Willey
    Citation: BMC Cancer 2023 23:783
    Content type: Research Published on:

  8. Ultra-hypofractionated image-guided stereotactic body radiotherapy (SBRT) is increasingly used for definitive treatment of localized prostate cancer. Magnetic resonance imaging-guided radiotherapy (MRgRT) faci...

    Authors: Ariel E. Marciscano, Sydney Wolfe, Xi Kathy Zhou, Christopher E. Barbieri, Silvia C. Formenti, Jim C. Hu, Ana M. Molina, David M. Nanus, Jones T. Nauseef, Douglas S. Scherr, Cora N. Sternberg, Scott T. Tagawa and Himanshu Nagar
    Citation: BMC Cancer 2023 23:781
    Content type: Study Protocol Published on:

  9. Although the standard therapy for advanced-stage hepatocellular carcinoma (HCC) is systemic chemotherapy, the combination of atezolizumab and bevacizumab (atezo + bev) with a high objective response rate may l...

    Authors: Masayuki Okuno, Takamichi Ishii, Akihiko Ichida, Akihiko Soyama, Nobuyuki Takemura, Seiko Hirono, Susumu Eguchi, Kiyoshi Hasegawa, Yasuharu Sasaki, Kohei Uemura, Norihiro Kokudo and Etsuro Hatano
    Citation: BMC Cancer 2023 23:780
    Content type: Study Protocol Published on:

  10. The optimal treatment strategy for resectable BRAF V600E mutant colorectal oligometastases (CRM) has not been established due to the rarity and rapid progression of the disease. Since the unresectable recurrence ...

    Authors: Shin Kobayashi, Hideaki Bando, Akinobu Taketomi, Takeshi Takamoto, Eiji Shinozaki, Manabu Shiozawa, Hiroki Hara, Kentaro Yamazaki, Koji Komori, Nobuhisa Matsuhashi, Takeshi Kato, Yoshinori Kagawa, Mitsuru Yokota, Eiji Oki, Keigo Komine, Shinichiro Takahashi…
    Citation: BMC Cancer 2023 23:779
    Content type: Study Protocol Published on:

  11. Skeletal muscle indices have been associated with improved peri-operative outcomes after surgical resection of non-small-cell lung cancer (NSCLC). However, it is unclear if these indices can predict long term ...

    Authors: Yeshwanth Vedire, Lindsay Nitsche, Madeline Tiadjeri, Victor McCutcheon, Jack Hall, Joseph Barbi, Sai Yendamuri and Andrew D. Ray
    Citation: BMC Cancer 2023 23:778
    Content type: Research Published on:

  12. Prehabilitation with exercise interventions during neoadjuvant chemotherapy (NACT) is effective in reducing physical and psychosocial chemotherapy-related adverse events in patients with cancer. In preclinical...

    Authors: Eva Kjeldsted, Gunn Ammitzbøll, Lars Bo Jørgensen, Alexey Lodin, Rasmus Dahlin Bojesen, Silvia Gonzalez Ceballos, Susanne Rosthøj, Anne-Vibeke Lænkholm, Søren T. Skou, Sandy Jack, Julie Gehl and Susanne Oksbjerg Dalton
    Citation: BMC Cancer 2023 23:777
    Content type: Study Protocol Published on:

  14. Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells. Although these agents extend progr...

    Authors: Shane O’Brien, Michael Butticello, Christine Thompson, Boris Wilson, Anastasia Wyce, Vivek Mahajan, Ryan Kruger, Helai Mohammad and Andy Fedoriw
    Citation: BMC Cancer 2023 23:775
    Content type: Research Published on:

  15. The tumor microenvironment (TME) plays a crucial role in tumorigenesis, progression, and therapeutic response in many cancers. This study aimed to comprehensively investigate the role of TME in colorectal canc...

    Authors: Xian-wen Guo, Rong-e Lei, Qing-nan Zhou, Guo Zhang, Bang-li Hu and Yun-xiao Liang
    Citation: BMC Cancer 2023 23:773
    Content type: Research Published on:

  16. Population based cancer registries (PBCRs) are accepted as the gold standard for estimating cancer incidence in any population. However, only 15% of the world’s population is covered by high quality cancer reg...

    Authors: Annet Nakaganda, Angela Spencer, Jackson Orem, Collins Mpamani, Henry Wabinga, Sarah Nambooze, Gertrude N. Kiwanuka, Raymond Atwine, Isla Gemmell, Andrew Jones and Arpana Verma
    Citation: BMC Cancer 2023 23:772
    Content type: Research Published on:

  17. High dose unilobar radioembolization (also termed ‘radiation lobectomy’)—the transarterial unilobar infusion of radioactive microspheres as a means of controlling tumour growth while concomitantly inducing fut...

    Authors: Daan Andel, Marnix G. E. H. Lam, Joep de Bruijne, Maarten L. J. Smits, Arthur J. A. T. Braat, Adriaan Moelker, Erik Vegt, Simeon J. S. Ruiter, Walter Noordzij, Gianluca Grazi, Giulio E. Vallati, Roel J. Bennink, Otto M. van Delden, Onno W. Kranenburg, Jan N. M. Ijzermans, Maarten W. Nijkamp…
    Citation: BMC Cancer 2023 23:771
    Content type: Study protocol Published on:

  18. Adjuvant chemotherapy is recommended as the standard treatment for patients with stage II/III resected gastric cancer. However, it is unclear whether older patients also benefit from an adjuvant chemotherapy s...

    Authors: Yu-Hsuan Shih, Hsin-Chen Lin, Po-Wei Liao, Cheng-Wei Chou, Cheng-Hsien Lin, Chiann-Yi Hsu, Chieh-Lin Jerry Teng, Feng-Hsu Wu, Shao-Ciao Luo and Shao-Hsuan Kao
    Citation: BMC Cancer 2023 23:770
    Content type: Research Published on:

  21. Older primary central nervous system lymphoma (PCNSL) patients have an inferior prognosis compared to younger patients because available evidence on best treatment is scarce and treatment delivery is challengi...

    Authors: Lisa K Isbell, Roswitha Uibeleisen, Alexander Friedl, Elvira Burger, Tatja Dopatka, Florian Scherer, Andras Orban, Eliza Lauer, Natalie Malenica, Inna Semenova, Annika Vreden, Elke Valk, Julia Wendler, Simone Neumaier, Heidi Fricker, Abed Al Hadi El Rabih…
    Citation: BMC Cancer 2023 23:767
    Content type: Study Protocol Published on:

  22. Women with early breast cancer who meet guideline-based criteria should be offered breast conserving surgery (BCS) with adjuvant radiotherapy as an alternative to mastectomy. New Zealand (NZ) has documented et...

    Authors: Karen Bartholomew, Mazin Ghafel, Sandar Tin Tin, Phyu S Aye, J Mark Elwood, Claire Hardie, Nina Scott, Jacquie Kidd, Reena Ramsaroop and Ian Campbell
    Citation: BMC Cancer 2023 23:766
    Content type: Research Published on:

  23. Although anaplastic lymphoma kinase (ALK) is overexpressed in several primary solid tumor types, its role in endometrial carcinoma (Em Ca) remains unclear.

    Authors: Ako Yokoi, Yusaku Nakamura, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Youhei Harada, Naomi Fukagawa and Makoto Saegusa
    Citation: BMC Cancer 2023 23:765
    Content type: Research Published on:

  24. Currently, there is no standard treatment for managing relapse in patients with acute myeloid leukemia and myelodysplastic syndrome (AML/MDS) after allogeneic hematopoietic cell transplantation. Venetoclax-bas...

    Authors: Yufeng Du, Chunhong Li, Zhijia Zhao, Yikun Liu, Chengtao Zhang and Jinsong Yan
    Citation: BMC Cancer 2023 23:764
    Content type: Research Published on:

  25. In the tumor microenvironment (TME), the dynamic interaction between tumor cells and immune cells plays a critical role in predicting the prognosis of colorectal cancer. This study introduces a novel approach ...

    Authors: Qicong Chen, Ming Cai, Xinjuan Fan, Wenbin Liu, Gang Fang, Su Yao, Yao Xu, Qian Li, Yingnan Zhao, Ke Zhao, Zaiyi Liu and Zhihua Chen
    Citation: BMC Cancer 2023 23:763
    Content type: Research Published on:

  26. Glioblastoma patients commonly develop resistance to temozolomide chemotherapy. Hypoxia, which supports chemotherapy resistance, favors the expansion of glioblastoma stem cells (GSC), contributing to tumor rel...

    Authors: Nadia Sousa, Carsten Geiß, Laura Bindila, Ingo Lieberwirth, Ella Kim and Anne Régnier-Vigouroux
    Citation: BMC Cancer 2023 23:762
    Content type: Research Published on:

  27. This study aims to evaluate the relationship between age, period, and birth cohort with the incidence trends of Nasopharyngeal Carcinoma (NPC) in Hong Kong, make projections through 2030 and parse the drivers ...

    Authors: Xiaoyan Wang, Haifeng Sun, Linchang Li, Zhenhai Gan, Xiaoming Wu and Jianqiang Du
    Citation: BMC Cancer 2023 23:761
    Content type: Research Published on:

  29. Lung cancer is reported to be the leading cause of death in males and females, globally. Increasing evidence highlights the paramount importance of Lactate dehydrogenase D (LDHD) in different types of cancers,...

    Authors: Yu Zhang, Tianyi Zhang, Yingdong Zhao, Hongdi Wu, Qiang Zhen, Suwei Zhu and Shaoshuai Hou
    Citation: BMC Cancer 2023 23:759
    Content type: Research Published on:

  30. Alcohol consumption has been associated with increased risks of certain site-specific cancers and decreased risks of some other cancers. There is, however, little reliable evidence as to whether the alcohol-as...

    Authors: Sarah Floud, Carol Hermon, Rachel F Simpson and Gillian K Reeves
    Citation: BMC Cancer 2023 23:758
    Content type: Research Published on:

  33. This project aimed to research the significance of THRIL in the diagnosis of benign and malignant solitary pulmonary nodules (SPNs) and to investigate the role of THRIL/miR-99a in malignant SPNs.

    Authors: Xinyu Chen, Xianji Zhu, Wenjun Yan, Luan Wang, Dongming Xue, Shouying Zhu, Jiajun Pan, Yufeng Li, Qixiang Zhao and Dong Han
    Citation: BMC Cancer 2023 23:755
    Content type: Research Published on:

  34. Spatial analysis can identify communities where men are at risk for aggressive prostate cancer (PCan) and need intervention. However, there are several definitions for aggressive PCan. In this study, we evalua...

    Authors: Daniel Wiese, Tesla D. DuBois, Kristen A. Sorice, Carolyn Y. Fang, Camille Ragin, Mary B. Daly, Adam C. Reese, Kevin A. Henry and Shannon M. Lynch
    Citation: BMC Cancer 2023 23:754
    Content type: Research Published on:

  35. Small-cell lung cancer (SCLC) is a highly aggressive and lethal malignancy that accounts for 10–15% of lung cancers, and it is generally divided into limited and extensive stage. The standard of care for patie...

    Authors: Deyu Li, Zhangzhou Huang, Jiangming Zhong, Li Lin, Guifeng Zhang, Wu Zhuang and Zhenhua Liu
    Citation: BMC Cancer 2023 23:753
    Content type: Study protocol Published on:

  36. An increasing amount of research has speculated that necroptosis could be a therapeutic strategy for treating cancer. However, understanding the prognostic value of the necroptosis-related long non-coding RNAs...

    Authors: Jianlan Liu, Binlin Luo, Pengpeng Zhang, Keyu Jiang, Zuoqiong Hou, Xiaojian Cao and Jian Tang
    Citation: BMC Cancer 2023 23:752
    Content type: Research Published on:

  37. This study aims to investigate the predictive value of the combined index smni(skeletal muscle index (SMI)-prognostic nutrition index(PNI)) for the postoperative survival of patients with advanced gastric canc...

    Authors: Yubo Han, Ju Wu, Rui Ji, Hao Tan, Simiao Tian, Jiajun Yin, Jian Xu, Xi Chen, Wenfei Liu and Hongzhang Cui
    Citation: BMC Cancer 2023 23:751
    Content type: Research Published on:

  38. 3D culture is increasingly used in cancer research, as it allows the growth of cells in an environment that mimics in vivo conditions. Metastases are the primary cause of morbidity and mortality in cancer pati...

    Authors: Erika Naakka, Wafa Wahbi, Riia Tiikkaja, Krista Juurikka, Toni Sandvik, Petri Koivunen, Timo Autio, Jukka Tikanto, Janne Väisänen, Hannu Tuominen, Anne Talvensaari-Mattila, Ahmed Al-Samadi, Rabah Soliymani, Pirjo Åström, Maija Risteli and Tuula Salo
    Citation: BMC Cancer 2023 23:750
    Content type: Research Published on:

  39. Glioblastoma (GBM) is a type of highly malignant brain tumor that is known for its significant intratumoral heterogeneity, meaning that there can be a high degree of variability within the tumor tissue. Despit...

    Authors: Nannan Zhao, Siyuan Weng, Zaoqu Liu, Hui Xu, Yuqin Ren, Chunguang Guo, Long Liu, Zhenyu Zhang, Yuchen Ji and Xinwei Han
    Citation: BMC Cancer 2023 23:749
    Content type: Research Published on:

  40. Patients with advanced pancreatic cancer have a poor prognosis and high burden of cancer-related symptoms. It is necessary to assess the trade-off of clinical benefits and possible harms of treatments with ant...

    Authors: Josefina Salazar, Javier Bracchiglione, Olga Savall-Esteve, Alba Antequera, David Bottaro-Parra, Marta Gutiérrez-Valencia, Susana Martínez-Peralta, Carles Pericay, Ariadna Tibau and Xavier Bonfill
    Citation: BMC Cancer 2023 23:748
    Content type: Research Published on:

  41. Lung cancer is the third most common type of cancer in the UK. Treatment outcomes are poor and UK deaths from lung cancer are higher than any other cancer. Prehabilitation has shown to be an important means of...

    Authors: Kelly Wade-Mcbane, Alex King, Catherine Urch, Julian Jeyasingh-Jacob, Andrew Milne and Clair Le Boutillier
    Citation: BMC Cancer 2023 23:747
    Content type: Research Published on:

  42. This study aimed to compare the efficacy and safety of high-dose methotrexate (HD-MTX) versus teniposide (TEN) in patients with newly diagnosed immunocompetent primary central nervous system lymphomas (PCNSLs).

    Authors: Kaili Zhong, Yanyan Shi, Yuhuan Gao, Huilai Zhang, Mingzhi Zhang, Qiaohua Zhang, Xinan Cen, Mei Xue, Yan Qin, Yu Zhao, Liling Zhang, Rong Liang, Ningju Wang, Yan Xie, Yu Yang, Aichun Liu…
    Citation: BMC Cancer 2023 23:746
    Content type: Research Published on:

  44. ‘Prehabilitation’ interventions aim to enhance individuals’ physical fitness prior to cancer treatment, typically involve exercise training as a key component, and may continue to support physical activity, st...

    Authors: Rachael Powell, Amy Davies, Kirsty Rowlinson-Groves, David P French, John Moore and Zoe Merchant
    Citation: BMC Cancer 2023 23:744
    Content type: Research Published on:

  45. The prognostic role of either forkhead box A1 (FOXA1) or anterior gradient 2 (AGR2) in breast cancer has been found separately. Considering that there were interplays between them depending on ER status, we ai...

    Authors: Meng Zhou, Xing-li Gan, Yue-xiang Ren, Qian-xin Chen, Yuan-zhong Yang, Zi-jin Weng, Xiao-fang Zhang, Jie-xia Guan, Lu-ying Tang and Ze-fang Ren
    Citation: BMC Cancer 2023 23:743
    Content type: Research Published on:

  46. Bone sarcomas are rare tumors representing 0.2% of all cancers. While osteosarcoma and Ewing sarcoma mainly affect children and young adults, chondrosarcoma and chordoma have a preferential incidence in people...

    Authors: Marie-Anaïs Locquet, Mehdi Brahmi, Jean-Yves Blay and Aurélie Dutour
    Citation: BMC Cancer 2023 23:742
    Content type: Review Published on:

  47. SPOCK3 is a secreted extracellular matrix proteoglycan. This study aimed to investigate the effect of SPOCK3 on the malignant progression of prostate cancer and to construct a prognostic model to predict DFS o...

    Authors: Jiawen Luo, Cong Lai, Xiaoting Xu, Juanyi Shi, Jintao Hu, Kaixuan Guo, Yelisudan Mulati, Yunfei Xiao, Degeng Kong, Cheng Liu and Kewei Xu
    Citation: BMC Cancer 2023 23:741
    Content type: Research Published on:

  48. Authors: Farastuk Bozorgmehr, Inn Chung, Petros Christopoulos, Johannes Krisam, Marc A. Schneider, Lena Brückner, Daniel Wilhelm Mueller, Michael Thomas and Stefan Rieken
    Citation: BMC Cancer 2023 23:740
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2020 20:806

  49. Thyroid cancer (TC) overall survival at 5 years was estimated at 97% in mainland France over 2010–2015. Its prognosis is known to be affected by patient age, tumor histology, size, and extension. This study ai...

    Authors: Lyvio Lin, Thierry Almont, Murielle Beaubrun, Jonathan Macni, Aimée Pierre-Louis, Audrey Zabulon, Ciprian Draganescu, Lucien Lin, Nadia Sabbah, Moustapha Drame, Jacqueline Veronique-Baudin and Clarisse Joachim
    Citation: BMC Cancer 2023 23:739
    Content type: Research Published on:

  50. Genetic screening for pathogenic variants (PVs) in cancer predisposition genes can affect treatment strategies, risk prediction and preventive measures for patients and families. For decades, hereditary breast...

    Authors: Anna Öfverholm, Therese Törngren, Anna Rosén, Brita Arver, Zakaria Einbeigi, Karin Haraldsson, Anne Kinhult StÃ¥hlbom, Ekaterina Kuchinskaya, Annika Lindblom, Beatrice Melin, Ylva Paulsson-Karlsson, Marie Stenmark-Askmalm, Emma Tham, Anna von Wachenfeldt, Anders Kvist, Ã…ke Borg…
    Citation: BMC Cancer 2023 23:738
    Content type: Research article Published on:

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