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  1. Whether tumour-infiltrating lymphocytes (TILs) play different roles in different molecular subtypes of breast cancer remains unknown. Additionally, their prognostic and predictive value in different molecular ...

    Authors: Zhao-hua Gao, Cun-xin Li, Ming Liu and Jia-yuan Jiang

    Citation: BMC Cancer 2020 20:1150

    Content type: Research article

    Published on:

  2. Population-based analysis for the short-term non-bladder cancer related mortality among patients with non-metastatic bladder cancer is currently lacking. The objective of the current study was to assess and qu...

    Authors: Menghe Zhai, Chenye Tang, Ming Li, Xin Chen, Yigang Jin, Xiangjun Ying, Zhiling Tang, Xiao Wang, Yuntao Wu, Chun Sun, Kean Chen and Xiao Guo

    Citation: BMC Cancer 2020 20:1148

    Content type: Research article

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  3. Breast cancer is the most common malignancy in women, and it is also the leading cause of death in female patients; the most common pathological type of BC is infiltrating duct carcinoma (IDC). Some nomograms ...

    Authors: Zhangheng Huang, Chuan Hu, Kewen Liu, Luolin Yuan, Yinglun Li, Chengliang Zhao and Chanchan Hu

    Citation: BMC Cancer 2020 20:1145

    Content type: Research article

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  4. In order to obtain a high dose conformal index of tumor and steep dose fall-off in healthy tissues for brain metastasis stereotactic radiosurgery (SRS), the aim of this study was to investigate SRS planning op...

    Authors: Xuyao Yu, Yuwen Wang, Zhiyong Yuan, Hui Yu, Yongchun Song, Lujun Zhao and Ping Wang

    Citation: BMC Cancer 2020 20:1144

    Content type: Research article

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  5. Interleukin-1 receptor antagonist (IL1RN) has been reported as a biomarker of many cancers. However, the biological function of IL1RN in papillary thyroid carcinoma (PTC) remains undetermined.

    Authors: Zhenyu Xie, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Yu Lun, Shijie Xin and Jian Zhang

    Citation: BMC Cancer 2020 20:1143

    Content type: Research article

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  6. Prehabilitation with regular exercise and nutritional care for patients undergoing surgeries for malignant disease was recently introduced to increase physiologic reserve prior to the procedure, accelerate rec...

    Authors: Erik Rupnik, Matevz Skerget, Matjaz Sever, Irena Preloznik Zupan, Maja Ogrinec, Barbara Ursic, Natasa Kos, Peter Cernelc and Samo Zver

    Citation: BMC Cancer 2020 20:1142

    Content type: Research article

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  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Zhenhua Yin, Dejun Wu, Jianping Shi, Xiyi Wei, Nuyun Jin, Xiaolan Lu and Xiaohan Ren

    Citation: BMC Cancer 2020 20:1141

    Content type: Correction

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    The original article was published in BMC Cancer 2020 20:1062

  8. Allogeneic stem cell transplantation from haploidentical donor using an unmanipulated graft and post-transplantation cyclophosphamide (PT-Cy) is growing. Haploidentical transplantation with PT-Cy showed a majo...

    Authors: Luca Castagna, Alessandro Busca, Stefania Bramanti, Maria Raiola Anna, Michele Malagola, Fabio Ciceri, William Arcese, Daniele Vallisa, Francesca Patriarca, Giorgina Specchia, Roberto Raimondi, Raynier Devillier, Sabine Furst, Laura Giordano, Barbara Sarina, Jacopo Mariotti…

    Citation: BMC Cancer 2020 20:1140

    Content type: Research article

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  9. The recommended cumulative doxorubicin dose in soft tissue sarcoma (STS) treatment was based on cardiotoxicity data from retrospective studies of breast cancer patients. However, the treatment and prognosis of...

    Authors: Zhichao Tian, Yang Yang, Yonghao Yang, Fan Zhang, Po Li, Jiaqiang Wang, Jinpo Yang, Peng Zhang, Weitao Yao and Xin Wang

    Citation: BMC Cancer 2020 20:1139

    Content type: Research article

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  10. Women with an advantaged socioeconomic position (SEP) have a higher risk of developing breast cancer (BC). The reasons for this association do not seem to be limited to reproductive factors and remain to be un...

    Authors: Eloïse Berger, Noële Maitre, Francesca Romana Mancini, Laura Baglietto, Vittorio Perduca, Hélène Colineaux, Sabina Sieri, Salvatore Panico, Carlotta Sacerdote, Rosario Tumino, Paolo Vineis, Marie-Christine Boutron-Ruault, Gianluca Severi, Raphaële Castagné and Cyrille Delpierre

    Citation: BMC Cancer 2020 20:1138

    Content type: Research article

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  12. Hepatocellular carcinoma (HCC) is among the deadliest forms of cancer. While RNA-binding proteins (RBPs) have been shown to be key regulators of oncogenesis and tumor progression, their dysregulation in the co...

    Authors: Min Wang, Shan Huang, Zefeng Chen, Zhiwei Han, Kezhi Li, Chuang Chen, Guobin Wu and Yinnong Zhao

    Citation: BMC Cancer 2020 20:1136

    Content type: Research article

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  13. The epithelial-mesenchymal transition (EMT) plays a pivotal role in various physiological processes, such as embryonic development, tissue morphogenesis, and wound healing. EMT also plays an important role in ...

    Authors: Zizhen Zhang, Sheng Zheng, Yifeng Lin, Jiawei Sun, Ning Ding, Jingyu Chen, Jing Zhong, Liuhong Shi and Meng Xue

    Citation: BMC Cancer 2020 20:1135

    Content type: Research article

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  14. Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysi...

    Authors: Citrawati Dyah Kencono Wungu, Fis Citra Ariyanto, Gwenny Ichsan Prabowo, Soetjipto and Retno Handajani

    Citation: BMC Cancer 2020 20:1134

    Content type: Research article

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  15. Cervical cancer (CC) is one of the most common gynaecological cancers. The gene signature is believed to be reliable for predicting cancer patient survival. However, there is no relevant study on the relations...

    Authors: Luya Cai, Chuan Hu, Shanshan Yu, Lixiao Liu, Xiaobo Yu, Jiahua Chen, Xuan Liu, Fan Lin, Cheng Zhang, Wenfeng Li and Xiaojian Yan

    Citation: BMC Cancer 2020 20:1133

    Content type: Research article

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  16. Previous studies have revealed that nearly 15–20% of selected high-risk T1–2N0 breast cancers developed LRR after mastectomy. This study is aim to indentify the risk factors of locoregional recurrence (LRR) in...

    Authors: Jianyang Wang, Yu Tang, Hao Jing, Guangyi Sun, Jing Jin, Yueping Liu, Yongwen Song, Weihu Wang, Hui Fang, Bo Chen, Shunan Qi, Hua Ren, Ning Li, Yuan Tang, Ningning Lu, Yong Yang…

    Citation: BMC Cancer 2020 20:1132

    Content type: Research article

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  17. Hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) are malignancies with a leading lethality. With reference to interferons (IFNs) known to mediate antitumor activities, this study inve...

    Authors: Henriette Huschka and Sabine Mihm

    Citation: BMC Cancer 2020 20:1131

    Content type: Research article

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  18. The translational interest in the intratumoral heterogeneity of hepatocellular carcinoma (HCC) has been increasing. The dismal prognosis of this pathology is linked to the features of the HCC harbouring cancer...

    Authors: Jenny Krause, Johann von Felden, Christian Casar, Thorben W. Fründt, Johanna Galaski, Constantin Schmidt, Caroline Jung, Harald Ittrich, Sören A. Weidemann, Till Krech, Asmus Heumann, Jun Li, Lutz Fischer, Guido Sauter, Ansgar W. Lohse, Henning Wege…

    Citation: BMC Cancer 2020 20:1130

    Content type: Research article

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  19. The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for gallbladder carcinoma (GBC) came into force since 2018. However, the prognostic precision of this staging system has not been...

    Authors: Wei Jiang, Bingqing Zhao, Yongcheng Li, Dunfeng Qi and Daxing Wang

    Citation: BMC Cancer 2020 20:1129

    Content type: Research article

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  20. While immune-checkpoint inhibitors (ICIs) have transformed the field of oncology for advanced-stage cancers, they can lead to serious immune toxicities. Several systematic reviews have evaluated the risk of im...

    Authors: Zahra Karimian, Sandra Mavoungou, Joe-Elie Salem, Florence Tubach and Agnès Dechartres

    Citation: BMC Cancer 2020 20:1128

    Content type: Research article

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  21. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer and Birgit Luber

    Citation: BMC Cancer 2020 20:1127

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:1039

  23. An amendment to this paper has been published and can be accessed via the original article.

    Authors: E. B. Elimimian, L. Elson, E. Stone, R. S. Butler, M. Doll, S. Roshon, C. Kondaki, A. Padgett and Z. A. Nahleh

    Citation: BMC Cancer 2020 20:1125

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:899

  25. Schlafen 11 (SLFN11) was recently identified as a dominant determinant of sensitivity to DNA-targeting agents including platinum-based drugs. SLFN11 also reportedly enhances cellular radiosensitivity. In this ...

    Authors: Takuma Kagami, Mihoko Yamade, Takahiro Suzuki, Takahiro Uotani, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Satoshi Baba, Haruhiko Sugimura, Junko Murai, Yves Pommier and Takahisa Furuta

    Citation: BMC Cancer 2020 20:1123

    Content type: Research article

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  26. Peritoneal metastasis (PM) in patients with breast (BC) and endometrial cancer (EC) is rare and treatment options are limited. Pressurized IntraPeritoneal Aerosol Chemotherapy (PIPAC) has demonstrated efficacy...

    Authors: Günther A. Rezniczek, Urs Giger-Pabst, Omar Thaher and Clemens B. Tempfer

    Citation: BMC Cancer 2020 20:1122

    Content type: Research article

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  27. Lung tuberculosis (TB) and lung cancer have a complex relationship. Data concerning TB treatment in lung cancer patients are still incomplete. The aim of this study was to investigate the effects of anti-cance...

    Authors: Mei Chai and Qingming Shi

    Citation: BMC Cancer 2020 20:1121

    Content type: Research article

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  28. Previous research results on the predictive factors of neoadjuvant chemotherapy (NCT) efficacy in breast cancer are inconsistent, suggesting that the ability of a single factor to predict efficacy is insuffici...

    Authors: Shengyu Pu, Ke Wang, Yang Liu, Xiaoqin Liao, Heyan Chen, Jianjun He and Jian Zhang

    Citation: BMC Cancer 2020 20:1120

    Content type: Research article

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  29. Breast cancer (BC) is the second most common type of cancer worldwide. Among targeted therapies for Hormone Receptor-positive (HR+) and Human Epidermal growth factor Receptor 2-negative (HER2−) BC, the Cyclin-Dep...

    Authors: Oliviero Marinelli, Emanuela Romagnoli, Federica Maggi, Massimo Nabissi, Consuelo Amantini, Maria Beatrice Morelli, Matteo Santoni, Nicola Battelli and Giorgio Santoni

    Citation: BMC Cancer 2020 20:1119

    Content type: Research article

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  30. We previously reported that low-dose, short-course sunitinib prior to neoadjuvant doxorubicin-cyclophosphamide (AC) normalised tumour vasculature and improved perfusion, but resulted in neutropenia and delayed...

    Authors: Yvonne L. E. Ang, Gwo Fuang Ho, Ross A. Soo, Raghav Sundar, Sing Huang Tan, Wei Peng Yong, Samuel G. W. Ow, Joline S. J. Lim, Wan Qin Chong, Phyu Pyar Soe, Bee Choo Tai, Lingzhi Wang, Boon Cher Goh and Soo-Chin Lee

    Citation: BMC Cancer 2020 20:1118

    Content type: Research article

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  31. Novel agents such as proteasome inhibitors have been developed for several years to treat multiple myeloma. Although multiple myeloma is a low-risk disease for developing tumor lysis syndrome (TLS), treatment ...

    Authors: Masahiro Kondo, Yuji Hotta, Karen Yamauchi, Akimasa Sanagawa, Hirokazu Komatsu, Shinsuke Iida and Kazunori Kimura

    Citation: BMC Cancer 2020 20:1117

    Content type: Research article

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  32. FOLFOXIRI plus bevacizumab is used as a first-line therapy for patients with unresectable or metastatic colorectal cancer. However, there are no clear recommendations for second-line therapy after FOLFOXIRI pl...

    Authors: Hironaga Satake, Koji Ando, Eiji Oki, Mototsugu Shimokawa, Akitaka Makiyama, Hiroshi Saeki, Akihito Tsuji and Masaki Mori

    Citation: BMC Cancer 2020 20:1116

    Content type: Study protocol

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  33. In patients with metastatic cancer, the bone is the third-most common site of involvement. Radiation to painful bone metastases results in high rates of pain control and is an integral part of bone metastases ...

    Authors: Daniel B. Rosen, Cory D. Benjamin, Joanna C. Yang, Connor Doyle, Zhigang Zhang, Chris A. Barker, Max Vaynrub, T. Jonathan Yang and Erin F. Gillespie

    Citation: BMC Cancer 2020 20:1115

    Content type: Study protocol

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  35. Performance of urinary cytology is recommended as the part of a standard diagnostic workup and base surveillance regimens in upper tract urothelial carcinoma (UTUC). However, the effect of positive voided urin...

    Authors: Wen Liu, Zhankun Wang, Shuai Liu, Yu Yao, Yong Liu and Guiming Zhang

    Citation: BMC Cancer 2020 20:1113

    Content type: Research article

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  36. This study aimed to quantify the dosimetric differences between the planned and delivered dose to tumor and normal organs in locally advanced non-small cell lung cancer (LANSCLC) treated with hypofractionated ...

    Authors: Bin Wang, Da Quan Wang, Mao Sheng Lin, Shi Pei Lu, Jun Zhang, Li Chen, Qi Wen Li, Zhang Kai Cheng, Fang Jie Liu, Jin Yu Guo, Hui Liu and Bo Qiu

    Citation: BMC Cancer 2020 20:1112

    Content type: Research article

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  37. Nanoparticle albumin-bound paclitaxel (nab-PTX) has shown non-inferiority to paclitaxel (PTX) as second-line therapy for advanced gastric cancer (AGC) with fewer infusion-related reactions. The efficacy and sa...

    Authors: Mashiro Okunaka, Daisuke Kotani, Ken Demachi, Akihito Kawazoe, Takayuki Yoshino, Toshikatsu Kawasaki and Kohei Shitara

    Citation: BMC Cancer 2020 20:1111

    Content type: Research article

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  38. People are at a high risk of gastric cancer if their first-degree relatives suffered from atrophic gastritis (AG), intestinal metaplasia (IM), intraepithelial neoplasia (IEN), dysplasia (DYS), or gastric cance...

    Authors: Rui Wu, Cheng Yang, Lin Ji, Zhi-Ning Fan, Yu-Wen Tao and Qiang Zhan

    Citation: BMC Cancer 2020 20:1110

    Content type: Research article

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  40. There is no currently available treatment for peritoneal metastasis of gastric cancer. This phase II study aimed to evaluate the efficacy and safety of neoadjuvant systemic chemotherapy and hyperthermic intrap...

    Authors: Pengfei Yu, Zeyao Ye, Gaiguo Dai, Yanqiang Zhang, Ling Huang, Yian Du and Xiangdong Cheng

    Citation: BMC Cancer 2020 20:1108

    Content type: Research article

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  41. Pancreatic and periampullary carcinoma are aggressive tumours where preoperative assessment is challenging. Disseminated tumour cells (DTC) in the bone marrow (BM) are associated with impaired prognosis in a v...

    Authors: Harald Hugenschmidt, Knut Jørgen Labori, Cathrine Brunborg, Caroline Sophie Verbeke, Lars Thomas Seeberg, Cecilie Bendigtsen Schirmer, Anne Renolen, Elin Borgen, Bjørn Naume and Gro Wiedswang

    Citation: BMC Cancer 2020 20:1107

    Content type: Research article

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  42. Pathologic complete response (pCR) after neoadjuvant chemotherapy (NAC) is a predictor of improved outcomes in breast cancer. In patients with hormone receptor (HR)-positive, human epidermal growth factor rece...

    Authors: In Hee Lee, Soo Jung Lee, Jeeyeon Lee, Jin Hyang Jung, Ho Yong Park, Shin Young Jeong, Sang-woo Lee and Yee Soo Chae

    Citation: BMC Cancer 2020 20:1106

    Content type: Research article

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  43. Biliary tract cancer (BTC) has a poor prognosis and lacks a standardized second-line therapy. Vascular endothelial growth factor (VEGF), fibroblast growth factor receptor (FGFR) 4, and platelet-derived growth ...

    Authors: Makoto Ueno, Masafumi Ikeda, Takashi Sasaki, Fumio Nagashima, Nobumasa Mizuno, Satoshi Shimizu, Hiroki Ikezawa, Nozomi Hayata, Ryo Nakajima and Chigusa Morizane

    Citation: BMC Cancer 2020 20:1105

    Content type: Research article

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  44. The worldwide prevalence and incidence of neuroendocrine neoplasms (NEN) have been increasing recently, although few studies have analyzed data on the current situation of NENs in Japan. Here, the Japan Neuroe...

    Authors: Toshihiko Masui, Tetsuhide Ito, Izumi Komoto and Shinji Uemoto

    Citation: BMC Cancer 2020 20:1104

    Content type: Research article

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  45. Objectives were to build a machine learning algorithm to identify bloodstream infection (BSI) among pediatric patients with cancer and hematopoietic stem cell transplantation (HSCT) recipients, and to compare ...

    Authors: Lillian Sung, Conor Corbin, Ethan Steinberg, Emily Vettese, Aaron Campigotto, Loreto Lecce, George A. Tomlinson and Nigam Shah

    Citation: BMC Cancer 2020 20:1103

    Content type: Research article

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  46. Tumour subtype has a significant effect on bone metastasis in breast cancer, but population-based estimates of the prognosis of patients with bone metastases at breast cancer diagnosis are lacking. The aim of ...

    Authors: Xiao Li, Xiaoli Zhang, Jie Liu and Yinzhong Shen

    Citation: BMC Cancer 2020 20:1102

    Content type: Research article

    Published on:

  48. AminoIndex™ Cancer Screening (AICS (lung)) was developed as a screening test for lung cancer using a multivariate analysis of plasma-free amino acid (PFAA) profiles. According to the developed index composed o...

    Authors: Masahiko Higashiyama, Ryohei Miyazaki, Hiroshi Yamamoto, Takashi Anayama, Shinya Kikuchi, Kentaro Hirohashi, Jiro Okami, Tomohiro Maniwa, Toru Kimura, Kazumasa Orihashi and Fumio Imamura

    Citation: BMC Cancer 2020 20:1100

    Content type: Research article

    Published on:

  49. Identifying the mutation status of KRAS is important for optimizing treatment in patients with colorectal cancer (CRC). The aim of this study was to investigate the predictive value of haematological parameter...

    Authors: Yinghao Cao, Junnan Gu, Lizhao Yan, Shenghe Deng, Fuwei Mao, Wentai Cai, Hang Li, Xinghua Liu, Jiliang Wang, Ke Wu and Kailin Cai

    Citation: BMC Cancer 2020 20:1099

    Content type: Research article

    Published on:

  50. Follow-up after curative surgery is increasingly recognized as an important component of breast cancer care. Although current guideline regulates the follow-ups, there are no relevant studies on the adherence ...

    Authors: Ran Feng, Jingfeng Jing, Xiaojun Zhang, Ming Li and Jinnan Gao

    Citation: BMC Cancer 2020 20:1098

    Content type: Research article

    Published on:

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