A subset of lung adenocarcinoma with EGFR-tyrosine kinase inhibitor sensitizing mutations (mEGFR) is common in non-smokers and women, suggesting that mutational stressors other than smoking are involved.
Authors: Eun Young Kim, Arum Kim, Gaeun Lee, Hangsuck Lee and Yoon Soo Chang
microRNAs (miRNAs) are crucially important in the development of cancer. Their dysregulation, commonly observed in various types of cancer, is largely cancer-dependent. Thus, to understand the tumor biology an...
Authors: Aaron L. Sarver, Anne E. Sarver, Ce Yuan and Subbaya Subramanian
In case of high grade non-muscle invasive bladder cancer (HG-NMIBC), intravesical BCG represents the first-line treatment; despite the “gold” standard therapy, up to 50% of patients relapse, needing radical cy...
Authors: Marco Racioppi, Luca Di Gianfrancesco, Mauro Ragonese, Giuseppe Palermo, Emilio Sacco and Pier Francesco Bassi
The Body Image Scale (BIS) is a 10-item mono-factorial scale, designed to capture distress and symptoms related to body image in cancer patients. This paper describes the conversion and psychometric evaluation...
Authors: Maria Antonietta Annunziata, Barbara Muzzatti, Francesca Bomben, Cristiana Flaiban, Marika Piccinin and Valentina Solfrini
Myeloid-derived suppressor cells (MDSCs) is a heterogeneous population of immature myeloid cells, inhibiting both the innate and adaptive immunity. Recent studies validated that MDSCs caused immune suppression...
Authors: Lisha Ai, Shidai Mu, Yadan Wang, Huafang Wang, Li Cai, Wenzhu Li and Yu Hu
pN stage in the TNM classification has been the “gold standard” for lymph node staging of colorectal carcinomas, but this system recommends collecting at least 12 lymph nodes for the staging to be reliable. Ho...
Authors: Carlos Fortea-Sanchis, David Martínez-Ramos and Javier Escrig-Sos
Agarose encapsulated murine renal adenocarcinoma cells (RENCA macrobeads) are currently being investigated in clinical trials as a treatment for therapy-resistant metastatic colorectal cancer. We have previous...
Authors: Prithy C. Martis, Atira T. Dudley, Melissa A. Bemrose, Hunter L. Gazda, Barry H. Smith and Lawrence S. Gazda
More colon cancer patients are expected to fully recover after treatment due to earlier detection of cancer and improvements in general health- and cancer care. The objective of this study was to gather partic...
Authors: C. M. den Bakker, F. G. Schaafsma, J. A. F. Huirne, E. C. J. Consten, H. B. A. C. Stockmann, C. J. Rodenburg, G. J. de Klerk, H. J. Bonjer and J. R. Anema
The growing numbers of cancer survivors challenge delivery of high-quality survivorship care by healthcare systems. Innovative ways to improve care coordination for patients with cancer and multiple chronic co...
Authors: Simon J. Craddock Lee, Katelyn K. Jetelina, Emily Marks, Eric Shaw, Kevin Oeffinger, Deborah Cohen, Noel O. Santini, John V. Cox and Bijal A. Balasubramanian
There are racial/ethnic disparities in breast cancer mortality may be attributed to differences in receipt of adjuvant cancer treatment. Our purpose was to determine whether the mortality disparities could be ...
Authors: Albert J. Farias, Wen-Hsing Wu and Xianglin L. Du
Colorectal cancer (CRC) remains the second most common cancer in women worldwide. Physical activity (PA) has been associated with reduced risk of CRC; however, this has been demonstrated more consistently in m...
Metastatic melanoma is one of the most aggressive forms of cancer in humans. Among its types, mucosal melanomas represent one of the most highly metastatic and aggressive forms, with a very poor prognosis. Bec...
Authors: Zacharie Segaoula, Aline Primot, Frederic Lepretre, Benoit Hedan, Emmanuel Bouchaert, Kevin Minier, Laurent Marescaux, François Serres, Sylvie Galiègue-Zouitina, Catherine André, Bruno Quesnel, Xavier Thuru and Dominique Tierny
Glioblastoma (GB) is a highly invasive primary brain tumor that nearly always systematically recurs at the site of resection despite aggressive radio-chemotherapy. Previously, we reported a gene expression sig...
Authors: Annabelle Monnier, Rachel Boniface, Régis Bouvet, Amandine Etcheverry, Marc Aubry, Tony Avril, Véronique Quillien, Eric Chevet and Jean Mosser
Analysis of high microsatellite instability (MSI-H) phenotype in colorectal carcinoma (CRC) is important for evaluating prognosis and choosing a proper adjuvant therapy. Although the conventional MSI analysis ...
Authors: Mi Jang, Yujin Kwon, Hoguen Kim, Hyunki Kim, Byung Soh Min, Yehyun Park, Tae Il Kim, Sung Pil Hong and Won Kyu Kim
Timely assessment of cancer risk from current radiation exposure among medical radiation workers can contribute to the development of strategies to prevent excessive occupational radiation exposure. The purpos...
Authors: Won Jin Lee, Yeongchull Choi, Seulki Ko, Eun Shil Cha, Jaeyoung Kim, Young Min Kim, Kyoung Ae Kong, Songwon Seo, Ye Jin Bang and Yae Won Ha
Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of G...
Authors: Li Li, Yulun Huang, Yuge Gao, Tengfei Shi, Yunyun Xu, Huini Li, Marko Hyytiäinen, Jorma Keski-Oja, Qiuying Jiang, Yizhou Hu and Zhimin Du
Breast neoplasms are the most common cancer among women in Taiwan. Cognitive deficits are common complications of breast cancer survivors treated with chemotherapy. The most frequently observed disorders invol...
Authors: Tsung-Yuan Li, Vincent Chin-Hung Chen, Dah-Cherng Yeh, Shu-Ling Huang, Cheng-Nan Chen, Jyh-Wen Chai, Clayton Chi-Chang Chen and Jun-Cheng Weng
Impaired physical function due to chemotherapy-induced peripheral neuropathy (CIPN) symptoms may lead to diminished quality of life. However, even with the knowledge of the effects of CIPN on physical function...
Authors: Robert Knoerl, Edie Weller, Barbara Halpenny and Donna Berry
Epidemiological studies and cardiovascular prevention trials have shown that low-dose aspirin can reduce colorectal cancer (CRC) incidence and mortality, including inhibition of distant metastases. Metformin h...
Authors: Marilena Petrera, Laura Paleari, Matteo Clavarezza, Matteo Puntoni, Silvia Caviglia, Irene Maria Briata, Massimo Oppezzi, Eva Mihajlovic Mislej, Borut Stabuc, Michael Gnant, Thomas Bachleitner-Hofmann, Wilfried Roth, Dominique Scherer, Walter-E. Haefeli, Cornelia M. Ulrich and Andrea DeCensi
Prostate biopsy is the most common method for the diagnosis of prostate cancer and the basis for further treatment. Confirmation using radical prostatectomy specimens is the most reliable method for verifying ...
Authors: Zhipeng Mai, Zhien Zhou, Weigang Yan, Yu Xiao, Yi Zhou, Zhiyong Liang, Zhigang Ji and Hanzhong Li
Hodgkin’s lymphoma (HL) is characterized by a high background of inflammatory cells which play an important role for the pathogenesis of the disease. T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a...
Authors: Wenchao Li, Niclas C. Blessin, Ronald Simon, Martina Kluth, Kristine Fischer, Claudia Hube-Magg, Georgia Makrypidi-Fraune, Björn Wellge, Tim Mandelkow, Nicolaus F. Debatin, Laura Pott, Doris Höflmayer, Maximilian Lennartz, Guido Sauter, Jakob R. Izbicki, Sarah Minner…
Funnel chest is the most common chest deformity, occurring in 0.06–0.3% of the general population. When it occurs concomitantly with esophageal cancer, it hinders intrathoracic surgery that is necessary for tr...
The incidence of colorectal cancer (CRC) is expected to increase by 80% in year 2035. Even though advantages in treatment of CRC have being made over the last decades, the outcome remains poor. Recently, sever...
Authors: Nikoletta Dimitriou, Evangelos Felekouras, Ioannis Karavokyros, Andreas Alexandrou, Emmanuel Pikoulis and John Griniatsos
A change of cervical cancer screening algorithms to an HPV-based screening setting is discussed in many countries, due to higher sensitivity of HPV testing compared to cytology. Reliable triage methods are, ho...
Authors: Martina Schmitz, Kristin Eichelkraut, Dana Schmidt, Ilona Zeiser, Ziad Hilal, Zena Tettenborn, Alfred Hansel and Hans Ikenberg
The aim of the present study was to investigate the association between matrix metalloproteinase-9 (MMP-9) expression with BRAF V600E mutation and clinicopathological features, in Iranian papillary thyroid can...
Authors: Maryam Zarkesh, Azita Zadeh-Vakili, Mahdi Akbarzadeh, S. Ahmad Fanaei, Mehdi Hedayati and Fereidoun Azizi
Peritoneal dissemination is a critical prognostic factor in ovarian cancer. Although stabilized spheroid formation promotes cancer cell peritoneal dissemination in ovarian cancer, the associated oncogenes are ...
Pazopanib is a tyrosine kinase inhibitor indicated for the treatment of renal cell carcinoma and soft tissue sarcoma. Despite the high inter-patient variability in pharmacokinetic exposure, pazopanib is admini...
Authors: Stefanie L. Groenland, Daniela Katz, Alwin D. R. Huitema and Neeltje Steeghs
Afatinib is an oral irreversible epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitor (TKI) indicated in first-line treatment of advanced EGFR-mutant (EGFRm+) non-small cell lung cancer (NSCLC). D...
Authors: Wan-Ling Tan, Quan Sing Ng, Cindy Lim, Eng Huat Tan, Chee Keong Toh, Mei-Kim Ang, Ravindran Kanesvaran, Amit Jain, Daniel S. W. Tan and Darren Wan-Teck Lim
Treatment with nab-paclitaxel plus gemcitabine increases survival in patients with metastatic pancreatic cancer. However, the assessment of treatment efficacy and safety in non-selected patients in a real-life...
Authors: Ana Fernández, Mercedes Salgado, Adelaida García, Elvira Buxò, Ruth Vera, Jorge Adeva, Paula Jiménez-Fonseca, Guillermo Quintero, Cristina Llorca, Mamen Cañabate, Luis Jesús López, Andrés Muñoz, Patricia Ramírez, Paula González, Carlos López, Margarita Reboredo…
Osteosarcoma is the most common malignant bone tumor in children and young adults that produces aberrant osteoid. The aim of this study was to assess the utility of 2-deoxy-2-[18F-] fluoro-D-glucose ([18F] FDG) a...
Authors: María Collantes, Naiara Martínez-Vélez, Marta Zalacain, Lucia Marrodán, Margarita Ecay, María José García-Velloso, Marta María Alonso, Ana Patiño-García and Iván Peñuelas
The nudix family member enzyme MutT homologue-1 (MTH1) hydrolyses the oxidized nucleotides 8-oxo-dGTP and 2-hydroxy-dATP and thus prevents the incorporation of damaged nucleotides into nuclear and mitochondria...
Authors: Mosche Pompsch, Julia Vogel, Fabian Classen, Philip Kranz, George Iliakis, Helena Riffkin, Ulf Brockmeier and Eric Metzen
Cancers of the upper gastrointestinal tract commonly result in malnutrition, which increases morbidity and mortality. Current nutrition best practice lacks a mechanism to provide early and intensive nutrition ...
Authors: Kate Furness, Catherine E. Huggins, Lauren Hanna, Mary Anne Silvers, Paul Cashin, Liang Low, Daniel Croagh and Terry P. Haines
Recently, microRNA-20a (miR-20a) has been reported to influence the clinical features and may have prognostic value in human cancers. The present meta-analysis assessed the prognostic role of miR-20a in variou...
Authors: Donghua Huang, Yizhong Peng, Kaige Ma, Xiangyu Deng, Lu Tang, Doudou Jing and Zengwu Shao
Few studies have focused on quality of life (QoL) after treatment of malignant pleural mesothelioma (MPM). There are still questions as to which surgical procedure, extrapleural pneumonectomy (EPP) or pleurect...
Authors: Rebecca M. Schwartz, Wil Lieberman-Cribbin, Andrea Wolf, Raja M. Flores and Emanuela Taioli
The presence of hypoxic areas is common in all breast lesions but no data clearly correlate low oxygenation with the acquisition of malignant features by non-invasive cells, particularly by cells from ductal c...
To explore the diagnostic value of FAM19A4 methylation in high-risk human papilloma virus (hrHPV)-positive cervical samples from Chinese women for estimating cervical cancer or its precancerous lesions.
Authors: Qiaowen Bu, Sanfeng Wang, Jian Ma, Xiangcheng Zhou, Guiying Hu, Hua Deng, Xiaoli Sun, Xiaoshan Hong, Hengying Wu, Liang Zhang and Xiping Luo
To investigate whether PET/CT-guided bone marrow biopsy adds complementary information for evaluation of bone marrow involvement (BMI) in newly diagnosed lymphomas.
Authors: Bing Hao, Long Zhao, Na-na Luo, Dan Ruan, Yi-zhen Pang, Wei Guo, Hao Fu, Xiu-yu Guo, Zuo-ming Luo, Jing Wu, Hao-jun Chen, Hua Wu and Long Sun
Oesophageal carcinoma is one of the leading cancers in Sri Lanka. Recent advances in treatment modalities have drastically improved the survival of these patients. However, the quality of life (QoL) among the ...
Authors: Ishanka Ayeshwari Talagala and Carukshi Arambepola
Standard therapy for stage III non-small cell lung cancer with chemotherapy and conventional radiation has suboptimal outcomes. We hypothesized that a combination of surgery followed by stereotactic body radia...
Authors: Anurag K. Singh, Mark Hennon, Sung Jun Ma, Todd L. Demmy, Anthony Picone, Elizabeth U. Dexter, Chumy Nwogu, Kristopher Attwood, Wei Tan, Gregory M. Hermann, Simon Fung-Kee-Fung, Harish K. Malhotra, Sai Yendamuri and Jorge A. Gomez-Suescun
The aim of this study was to compare proximal fibular and proximal tibial sites regarding osteosarcoma in the proximal crus. Furthermore, we proposed a hypothesis explaining the differences.
Authors: Hao Yao, Bo Wang, Lili Wen, Qinglin Jin, Hongbo Li, Gang Huang, Junqiang Yin, Changye Zou, Xianbiao Xie and Jingnan Shen
Mammographic density is a known risk factor for breast cancer, but the underlying pathologic characteristics are not well understood. The current analysis investigated the expression of several markers of inte...
Authors: Gertraud Maskarinec, Dan Ju, Jaimie Fong, David Horio, Owen Chan, Lenora W. M. Loo and Brenda Y. Hernandez
Accurate and early prognosis of disease is essential to clinical decision making, particularly in diseases, such as HCC, that are typically diagnosed at a late stage in the course of disease and therefore carr...
Authors: Yunhong Tian, Jianlin Wu, Cristian Chagas, Yichao Du, Huan Lyu, Yunhong He, Shouliang Qi, Yong Peng and Jiani Hu
The dysregulation of miR-663a is frequently observed in many human cancers. However, the functional role and precise mechanism of miR-663a have been controversial in hepatocellular carcinoma (HCC) and need to ...
Authors: Chengshuo Zhang, Baomin Chen, Ao Jiao, Feng Li, Ning Sun, Guoqing Zhang and Jialin Zhang
Changes in cellular metabolism are now recognized as potential drivers of cancer development, rather than as secondary consequences of disease. Here, we explore the mechanism by which metabolic changes depende...
Authors: Diana Andrejeva, Jan-Michael Kugler, Hung Thanh Nguyen, Anders Malmendal, Mette Lind Holm, Birgitte Groenkaer Toft, Anand C. Loya and Stephen M. Cohen
The aim of this study was to propose a prognostic scoring system based on preoperative serum apolipoprotein A-1 and C-reactive protein (ApoA-1 and CRP, AC score) levels and to evaluate the prognostic value of ...
Authors: Minjie Mao, Xueping Wang, Hui Sheng, Yijun Liu, Lin Zhang, Shuqin Dai and Pei-dong Chi
It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterize...
Authors: Gloria Pelizzo, Veronica Veschi, Melissa Mantelli, Stefania Croce, Vincenzo Di Benedetto, Paolo D’Angelo, Alice Maltese, Laura Catenacci, Tiziana Apuzzo, Emanuela Scavo, Antonia Moretta, Matilde Todaro, Giorgio Stassi, Maria Antonietta Avanzini and Valeria Calcaterra
Previous epidemiological studies aimed at describing characteristics of breast (BC) and ovarian cancer (OC) patients tend to examine Hispanic populations using a mix of individuals that come from ethnically di...
Authors: Ariel Rodriguez-Velazquez, Rosa Velez, Jean Carlo Lafontaine, Claudia B. Colon-Echevarria, Rocio D. Lamboy-Caraballo, Ingrid Ramirez, Adalberto Mendoza, Patricia Casbas-Hernandez and Guillermo N. Armaiz-Pena
The incidence and mortality from prostate cancer is expected to increase in the next decade in Thailand. Despite the perceived lower risk in this population vs. developed, western countries, it is becoming an ...
Authors: Christian S. Alvarez, Eduardo Villamor, Rafael Meza, Laura S. Rozek, Hutcha Sriplung and Alison M. Mondul
