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  1. Cancer metastasis is the main cause of mortality in cancer patients. However, the drugs targeting metastasis processes are still lacking, which is partially due to the short of effective in vitro model for cell i...

    Authors: Rongrong Jiang, Jiechun Huang, Xiaotian Sun, Xianglin Chu, Fangrui Wang, Jie Zhou, Qihui Fan and Liewen Pang
    Citation: BMC Cancer 2022 22:438
  2. Regulatory T cells (Tregs) play an important role in the antitumor immune response in epithelial ovarian cancer (EOC). To understand the immune-inhibitory networks of EOC, we addressed the association between ...

    Authors: Sho Sato, Hirokazu Matsushita, Daisuke Shintani, Yukari Kobayashi, Nao Fujieda, Akira Yabuno, Tadaaki Nishikawa, Keiichi Fujiwara, Kazuhiro Kakimi and Kosei Hasegawa
    Citation: BMC Cancer 2022 22:437
  3. While mechanisms contributing to the progression and metastasis of colorectal cancer (CRC) are well studied, cancer stage-specific mechanisms have been less comprehensively explored. This is the focus of this ...

    Authors: Sara Rahiminejad, Mano R. Maurya, Kavitha Mukund and Shankar Subramaniam
    Citation: BMC Cancer 2022 22:436
  4. Patients with oesophageal and gastric cancer have a low likelihood of being cured and suffer from a broad spectrum of symptoms and problems that negatively affect their quality-of-life (QOL). Although the majo...

    Authors: Karin Dalhammar, Jimmie Kristensson, Dan Falkenback, Birgit H. Rasmussen and Marlene Malmström
    Citation: BMC Cancer 2022 22:434
  5. Malignant pleural mesothelioma (MPM) is a rare, aggressive malignancy of the pleural cavity linked to asbestos exposure. The combination of pemetrexed and platinum is a standard first-line therapy for malignan...

    Authors: Barbara Ziółkowska, Bożena Cybulska-Stopa, Dimitrios Papantoniou and Rafał Suwiński
    Citation: BMC Cancer 2022 22:432
  6. Circulating long non-coding RNAs (lncRNAs) have been demonstrated to serve as diagnostic or prognosis biomarkers for various disease. We aimed to elucidate the diagnostic efficacy of serum lncRNA SCARNA10 for ...

    Authors: Yawei Han, Wenna Jiang, Yu Wang, Meng Zhao, Yueguo Li and Li Ren
    Citation: BMC Cancer 2022 22:431
  7. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are used in treating cardiovascular diseases. Previous studies indicated that ACEIs/ARBs may benefit cancer patients by...

    Authors: Po-Chih Li, Ru-Yu Huang, Yu-Chien Yang, Kun-Pin Hsieh and Yi-Hsin Yang
    Citation: BMC Cancer 2022 22:430
  8. To evaluate the effect of regorafenib on soluble MHC class I polypeptide-related sequence A (MICA) (sMICA) level in vitro. In addition, we clinically examined whether its plasma levels were associated with reg...

    Authors: Jun Arai, Yumi Otoyama, Ken-ichi Fujita, Kaku Goto, Masayuki Tojo, Atsushi Katagiri, Hisako Nozawa, Yutaro Kubota, Takehiro Takahashi, Hiroo Ishida, Takuya Tsunoda, Natsumi Matsumoto, Keita Ogawa, Ryo Nakagawa, Ryosuke Muroyama, Naoya Kato…
    Citation: BMC Cancer 2022 22:428
  9. Diabetes is an established risk factor for endometrial cancer development but its impact on prognosis is unclear and epidemiological studies to date have produced inconsistent results. We aimed to conduct the ...

    Authors: Lauren McVicker, Christopher R. Cardwell, Lauren Edge, W Glenn McCluggage, Declan Quinn, James Wylie and Úna C. McMenamin
    Citation: BMC Cancer 2022 22:427
  10. Quality of life (QoL) is an important patient-reported outcome that has been studied extensively as an endpoint. There is a growing interest in factors that may influence QoL, such as personality. This descrip...

    Authors: Veerle Marieke Wintraecken, Sophie Vulik, Sabine de Wild, Carmen Dirksen, Linetta B. Koppert, Jolanda de Vries and Marjolein L. Smidt
    Citation: BMC Cancer 2022 22:426
  11. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Sorafenib is the first-line treatment for advanced HCC, but the anti-cancer effects remain to be improved as indi...

    Authors: Zibo Chen, Tao Yuan, Fangjie Yan, Song Ye, Qin Xie, Bo Zhang, Nengmin Lin, Qiaojun He, Bo Yang and Hong Zhu
    Citation: BMC Cancer 2022 22:425
  12. Liver cancer is a major global health concern due to the steady increases in its incidence and mortality. Transcription factors, yes-associated protein (YAP) and WW domain-containing transcription regulator pr...

    Authors: Hyuk Moon, Hyunjung Park, Min Jee Chae, Hye Jin Choi, Do Young Kim and Simon Weonsang Ro
    Citation: BMC Cancer 2022 22:423
  13. Authors: Lenny Gallardo-Alvarado, David Cantú-de León, Rebeca Ramirez-Morales, Gabriel Santiago-Concha, Salim Barquet-Muñoz, Rosa Salcedo-Hernandez, Cinthya Reyes, Sandra Perez-Alvarez, Delia Perez-Montiel, Carlos Perez-Plasencia, Elizabeth Trejo-Duran and Juan Pablo Galicia
    Citation: BMC Cancer 2022 22:422

    The original article was published in BMC Cancer 2022 22:401

  14. The architectural transcriptional regulator high-mobility group AT-hook 2 (HMGA2) is an oncofetal protein which has been reported to be ectopically expressed in a variety of cancers. A high expression of HMGA2...

    Authors: Ying Liu, Guangyao Lv, Jianxin Bai, Lingling Song, Elizabeth Ding, Lin Liu, Yuqin Tian, Qian Chen, Kai Li, Xianfeng Liu and Yan Ding
    Citation: BMC Cancer 2022 22:421
  15. The purpose of this study was to investigate and validate multiparametric magnetic resonance imaging (MRI)-based machine learning classifiers for early identification of poor responders after neoadjuvant chemo...

    Authors: Jia Wang, Jingjing Chen, Ruizhi Zhou, Yuanxiang Gao and Jie Li
    Citation: BMC Cancer 2022 22:420
  16. Globally cervical cancer incidence rate has been declining continuously. However, an unfavorable trend has been observed in China during the past decades, and the underlying reasons remain unclear. We hereby e...

    Authors: Ke Li, Huan Xu, Suixiang Wang, Pengzhe Qin and Boheng Liang
    Citation: BMC Cancer 2022 22:419
  17. Immune-check point inhibitors (ICPIs) for treatment of cancer patients sometimes induce potentially life-threatening immune-related adverse events (irAEs), which predict ICPIs treatment efficacy. Prediction of...

    Authors: Tomoyuki Matsunaga, Hiroaki Saito, Hirohiko Kuroda, Tomohiro Osaki, Sadamu Takahashi, Akemi Iwamoto, Yoji Fukumoto, Kenjiro Taniguchi, Kenji Fukuda, Wataru Miyauchi, Yuji Shishido, Kozo Miyatani and Yoshiyuki Fujiwara
    Citation: BMC Cancer 2022 22:418
  18. Benzamide-based radioligands targeting melanin were first developed for imaging melanoma and then for therapeutic purpose with targeted radionuclide therapy (TRT).

    Authors: Emilie Thivat, Jacques Rouanet, Philippe Auzeloux, Nicolas Sas, Elodie Jouberton, Sophie Levesque, Tommy Billoux, Sandrine Mansard, Ioana Molnar, Marion Chanchou, Giovanna Fois, Lydia Maigne, Jean-Michel Chezal, Elisabeth Miot-Noirault, Michel D’Incan, Xavier Durando…
    Citation: BMC Cancer 2022 22:417
  19. Salvage external beam radiotherapy (sEBRT) for patients with a biochemical recurrence (BCR) after radical prostatectomy provides a 5-year biochemical progression-free survival up to 60%. Multiple studies have ...

    Authors: F. H. E. Staal, J. Janssen, C. L. Brouwer, J. A. Langendijk, K. Ng Wei Siang, E. Schuit, I. J. de Jong, J. F. Verzijlbergen, R. J. Smeenk and S. Aluwini
    Citation: BMC Cancer 2022 22:416
  20. Several bone-seeking radionuclides have been developed for palliation of metastatic bone pain since 1956, however, so far radium-223 dichloride is the first and only Food and Drug Administration (FDA) approved...

    Authors: Zin W. Myint, Riham El Khouli, Bryan Lemieux, Donglin Yan, William H. St. Clair, Xiaoqi Liu and Charles A. Kunos
    Citation: BMC Cancer 2022 22:415
  21. Stomach cancer is one the most common neoplasms with high mortality. However, fear of cancer recurrence (FCR) in stomach cancer survivors has been scarcely evaluated. Thus, the aim of this study was to evaluat...

    Authors: Jinyoung Shin, Dong Wook Shin, Jungkwon Lee, JiHye Hwang, Ji Eun Lee, BeLong Cho and Yun–Mi Song
    Citation: BMC Cancer 2022 22:414
  22. This study was to determine the prevalence and clinical significance of clonal hematopoiesis (CH)-related variants, and somatic and germline mutations in cancer patients and healthy individuals.

    Authors: Chieh-Min Chang, Kuei-Ching Lin, Nien-En Hsiao, Wei-An Hong, Chia-Yu Lin, Ta-Chih Liu, Ya-Sian Chang and Jan-Gowth Chang
    Citation: BMC Cancer 2022 22:413
  23. Routine measurement of tumor markers is not recommended in daily clinical practice for patients with cancer of unknown primary (CUP). We evaluated the diagnostic value of tumor markers in identifying favorable...

    Authors: Shigemasa Takamizawa, Tatsunori Shimoi, Masayuki Yoshida, Momoko Tokura, Shu Yazaki, Chiharu Mizoguchi, Ayumi Saito, Shosuke Kita, Kasumi Yamamoto, Yuki Kojima, Hitomi Sumiyoshi-Okuma, Tadaaki Nishikawa, Emi Noguchi, Kazuki Sudo and Kan Yonemori
    Citation: BMC Cancer 2022 22:412
  24. Genomic instability and chemoresistance can arise in cancer due to a unique form of plasticity: that of polyploid giant cancer cells (PGCCs). These cells form under the stress of chemotherapy and have higher t...

    Authors: Robert R. Bowers, Maya F. Andrade, Christian M. Jones, Shai White-Gilbertson, Christina Voelkel-Johnson and Joe R. Delaney
    Citation: BMC Cancer 2022 22:410
  25. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12885-019-5656-7.

    Authors: Qi Wang, Zixiang Wu, Tianwei Zhan, Shuai Fang, Sai Zhang, Gang Shen and Ming Wu
    Citation: BMC Cancer 2022 22:409
  26. Although uveal melanoma (UM) at the early stage is controllable to some extent, it inevitably ultimately leads to death due to its metastasis. At present, the difficulty is that there is no way to effectively ...

    Authors: Xifeng Fei, Xiangtong Xie, Ruwei Qin, Anqi Wang, Xuan Meng, Fei Sun, Yifan Zhao, Dongyi Jiang, Hanchun Chen, Qiang Huang, Xiaoyan Ji and Zhimin Wang
    Citation: BMC Cancer 2022 22:408
  27. Immune checkpoint inhibitor (ICI) therapies represent a major advance in treating a variety of advanced-stage malignancies. Nevertheless, only a subset of patients benefit, even when selected based on approved...

    Authors: Harsha Ranganath, Amit L. Jain, Justin R. Smith, Julie Ryder, Amina Chaudry, Emily Miller, Felicia Hare, Poojitha Valasareddy, Robert S. Seitz, David R. Hout, Matthew G. Varga, Brock L. Schweitzer, Tyler J. Nielsen, Janice Mullins, Douglas T. Ross, David R. Gandara…
    Citation: BMC Cancer 2022 22:407
  28. The SNCA gene is a critical gene in Parkinson’s disease (PD) pathology. Accumulating evidence indicates that SNCA is involved in tumorigenesis; however, the role of SNCA in lung adenocarcinoma (LUAD) remains uncl...

    Authors: Xiuao Zhang, Zhengcun Wu and Kaili Ma
    Citation: BMC Cancer 2022 22:406

    The Correction to this article has been published in BMC Cancer 2022 22:485

  29. There is strong evidence that disease progression, drug response and overall clinical outcomes of CML disease are not only decided by BCR/ABL1 oncoprotein but depend on accumulation of additional genetic and e...

    Authors: Sameer Ahmad Guru, Mamta Pervin Sumi, Rashid Mir, Mirza Masroor Ali Beg, Bidhan Chandra koner and Alpana Saxena
    Citation: BMC Cancer 2022 22:405

    The Correction to this article has been published in BMC Cancer 2022 22:439

  30. In this study, we performed a molecular evaluation of primary pancreatic adenocarcinoma (PAAD) based on the comprehensive analysis of energy metabolism-related gene (EMRG) expression profiles.

    Authors: Cong Tan, Xin Wang, Xu Wang, Weiwei Weng, Shu-juan Ni, Meng Zhang, Hesheng Jiang, Lei Wang, Dan Huang, Weiqi Sheng and Mi-die Xu
    Citation: BMC Cancer 2022 22:404
  31. R-CHOP with or without radiotherapy is the standard treatment for limited-stage diffuse large B-cell lymphoma (DLBCL). To prevent overtreatment, we assessed whether four cycles of CHOP plus six applications of...

    Authors: Jia Jin, Dongmei Ji, Zuguang Xia, Kai Xue, Qunling Zhang, Yizhen Liu, Junning Cao, Xiaonan Hong, Juan J. Gu, Ye Guo and Fangfang Lv
    Citation: BMC Cancer 2022 22:403
  32. Extranodal extension (ENE) is a poor prognostic factor for oral squamous cell carcinoma (OSCC). Identifying ENE by clinical and/or radiological examination is difficult, thereby leading to unnecessary neck dis...

    Authors: Yuri Noda, Mitsuaki Ishida, Yasuhiro Ueno, Takuo Fujisawa, Hiroshi Iwai and Koji Tsuta
    Citation: BMC Cancer 2022 22:402
  33. Even with different histologic origins, squamous cell carcinoma (SCC) and adenocarcinoma (AC) are considered a single entity, and the first-line treatment is the same. Locally advanced disease at the diagnosis...

    Authors: Lenny Gallardo-Alvarado, David Cantú-de León, Rebeca Ramirez-Morales, Gabriel Santiago-Concha, Salim Barquet-Muñoz, Rosa Salcedo-Hernandez, Cinthya Reyes, Sandra Perez-Alvarez, Delia Perez-Montiel, Carlos Perez-Plasencia, Elizabeth Trejo-Duran and Juan Pablo Galicia
    Citation: BMC Cancer 2022 22:401

    The Correction to this article has been published in BMC Cancer 2022 22:422

  34. Glioblastoma multiforme (GBM) is the most common high-grade malignant brain tumour in adults and arises from the glial cells in the brain. The prognosis of treated GBM remains very poor with 5-year survival ra...

    Authors: Einthavy Arunachalam, William Rogers, Guy R. Simpson, Carla Möller-Levet, Gemma Bolton, Mohammed Ismael, Christopher Smith, Karl Keegen, Izhar Bagwan, Tim Brend, Susan C. Short, Bangxing Hong, Yoshihiro Otani, Balveen Kaur, Nicola Annels, Richard Morgan…
    Citation: BMC Cancer 2022 22:400
  35. Cancer of Unknown Primary (CUP) is a metastatic cancer for which the primary lesion remains unidentifiable during life and little is also known about the modifiable risk factors that contribute to its developm...

    Authors: Karlijn E. P. E. Hermans, Piet A. van den Brandt, Caroline Loef, Rob L. H. Jansen and Leo J. Schouten
    Citation: BMC Cancer 2022 22:399
  36. A more extensive surgical resection of glioma contributes to improved overall survival (OS) and progression-free survival (PFS). However, some patients miss the chance of surgical resection when the tumor invo...

    Authors: Congxiao Wang, Chao Liu, Jun Chen, Han Jiang, Wei Zhang, Lili Yang, Xueda Li, Zixiang Li, Lijing Peng, Xiaokun Hu and Peng Sun
    Citation: BMC Cancer 2022 22:397
  37. Cancer-therapy related cardiotoxicity (CTRCT) is a significant and frequent complication of monoclonal antibody directed therapy, especially Trastuzumab, for human epidermal growth factor receptor 2 (HER2) ove...

    Authors: Mattia Lunardi, Ahmed Al-Habbaa, Mahmoud Abdelshafy, Matthew G. Davey, Ahmed Elkoumy, Sandra Ganly, Hesham Elzomor, Christian Cawley, Faisal Sharif, James Crowley, Michael Kerin, William Wijns, Aoife Lowery and Osama Soliman
    Citation: BMC Cancer 2022 22:396
  38. Saline hydration with addition of mannitol have commonly been the strategy to avoid cisplatin induced acute kidney injury (AKI). While the initial reports demonstrated that mannitol diuresis decreased cisplati...

    Authors: Andhika Rachman, Syahidatul Wafa, Pringgodigdo Nugroho and Sukamto Koesnoe
    Citation: BMC Cancer 2022 22:395
  39. Recently it has been recognized that stromal markers could be used as a clinically relevant biomarker for therapy response and prognosis. Here, we report on a serum marker for stromal activation, A Disintegrin...

    Authors: Sanne ten Hoorn, Cynthia Waasdorp, Martijn G. H. van Oijen, Helene Damhofer, Anne Trinh, Lan Zhao, Lisanne J. H. Smits, Sanne Bootsma, Gabi W. van Pelt, Wilma E. Mesker, Linda Mol, Kaitlyn K. H. Goey, Miriam Koopman, Jan Paul Medema, Jurriaan B. Tuynman, Inti Zlobec…
    Citation: BMC Cancer 2022 22:394
  40. For CD19-positive relapsed/refractory B-cell acute lymphoblastic leukemia (r/r B-ALL) after treatment with murine CD19 (mCD19) CAR-T, the reinfusion of mCD19 CAR-T cells may be ineffective due to anti-mouse si...

    Authors: Lihong An, Yuehui Lin, Biping Deng, Zhichao Yin, Defeng Zhao, Zhuojun Ling, Tong Wu, Yongqiang Zhao, Alex H. Chang, Chunrong Tong and Shuangyou Liu
    Citation: BMC Cancer 2022 22:393
  41. To present a systematic review of the literature and a meta-analysis evaluating the oncological safety of autologous fat grafting (AFG).

    Authors: Rodrigo Goncalves, Bruna Salani Mota, Bruno Sobreira-Lima, Marcos Desidério Ricci, José Maria Soares Jr, Alexandre Mendonça Munhoz, Edmund Chada Baracat and José Roberto Filassi
    Citation: BMC Cancer 2022 22:391
  42. Adjuvant chemotherapy for stage II colorectal cancer (CRC) is considered appropriate for patients with risk factors for recurrence, rather than for all patients uniformly. However, the risk factors for recurre...

    Authors: Takuki Yagyu, Manabu Yamamoto, Akimitsu Tanio, Kazushi Hara, Ken Sugezawa, Chihiro Uejima, Kyoichi Kihara, Shigeru Tatebe, Yasuro Kurisu, Shunsuke Shibata, Toshio Yamamoto, Hiroshi Nishie, Setsujo Shiota, Hiroaki Saito, Takuji Naka, Kenji Sugamura…
    Citation: BMC Cancer 2022 22:390
  43. Colposcopy alone can result in misidentification of high-grade squamous intraepithelial or worse lesions (HSIL +), especially for women with Type 3 transformation zone (TZ) lesions, where colposcopic assessmen...

    Authors: Bingrui Wei, Bo Zhang, Peng Xue, Samuel Seery, Jiaxu Wang, Qing Li, Yu Jiang and Youlin Qiao
    Citation: BMC Cancer 2022 22:388

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