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  1. The loss of a single copy of adenomatous polyposis coli (Apc) in leucine-rich repeats and immunoglobulin-like domains 1 (Lrig1)-expressing colonic progenitor cells induces rapid growth of adenomas in mice with hi...

    Authors: Jessica L. Preston and Nicholas Stiffler

    Citation: BMC Cancer 2020 20:126

    Content type: Research article

    Published on:

  2. Patients with human papillomavirus-positive (HPV+) oropharyngeal squamous cell carcinoma (OPC) have substantially better treatment response and overall survival (OS) than patients with HPV-negative disease. Tr...

    Authors: Anthony C. Nichols, Pencilla Lang, Eitan Prisman, Eric Berthelet, Eric Tran, Sarah Hamilton, Jonn Wu, Kevin Fung, John R. de Almeida, Andrew Bayley, David P. Goldstein, Antoine Eskander, Zain Husain, Houda Bahig, Apostolos Christopoulous, Michael Hier…

    Citation: BMC Cancer 2020 20:125

    Content type: Study protocol

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  3. Colorectal cancer (CRC) is the second leading cancer killer in the US today and patients with metastatic disease have only a 14% 5-year survival. One of the most impactful recent advances in cancer therapy, im...

    Authors: Yuanyuan Shen, Yue Guan, Justin J. Hummel, Chi-Ren Shyu and Jonathan B. Mitchem

    Citation: BMC Cancer 2020 20:124

    Content type: Research article

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  4. Melanoma can be lethal if not detected early and treated. Early detection can be facilitated via skin self-examination (SSE) and as such, SSE is part of melanoma follow-up care for individuals with a prior his...

    Authors: Adina Coroiu, Chelsea Moran, Catherine Bergeron, Martin Drapeau, Beatrice Wang, Abbas Kezouh, Jochen Ernst, Gerald Batist and Annett Körner

    Citation: BMC Cancer 2020 20:123

    Content type: Research article

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  5. Currently, complete surgical resection represents the only potentially curative treatment option for Biliary Tract Cancer (BTC) including Gallbladder Cancer (GBC). Even after curative resection, 5-year OS is o...

    Authors: Thorsten O. Goetze, Wolf O. Bechstein, Ulli Simone Bankstahl, Tobias Keck, Alfred Königsrainer, Sven A. Lang, Claudia Pauligk, Pompiliu Piso, Arndt Vogel and Salah-Eddin Al-Batran

    Citation: BMC Cancer 2020 20:122

    Content type: Study protocol

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  7. The interaction of programmed death-1 protein (PD-1) and programmed death-1 ligand (PD-L1) produces immunosuppressive activity, protecting tumor cells from anti-tumor immunity and possibly releasing soluble PD...

    Authors: Inju Cho, Hansang Lee, Sang Eun Yoon, Kyung Ju Ryu, Young Hyeh Ko, Won Seog Kim and Seok Jin Kim

    Citation: BMC Cancer 2020 20:120

    Content type: Research article

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  8. Ductal carcinoma in situ is a non-obligate precursor of invasive breast carcinoma and presents a potential risk of over or undertreatment. Finding molecular biomarkers of disease progression could allow for mo...

    Authors: Raquel Spinassé Dettogni, Elaine Stur, Ana Carolina Laus, René Aloísio da Costa Vieira, Márcia Maria Chiquitelli Marques, Iara Viana Vidigal Santana, José Zago Pulido, Laura Fregonassi Ribeiro, Narelle de Jesus Parmanhani, Lidiane Pignaton Agostini, Raquel Silva dos Reis, Eldamária de Vargas Wolfgramm dos Santos, Lyvia Neves Rebello Alves, Fernanda Mariano Garcia, Jéssica Aflávio Santos, Diego do Prado Ventorim…

    Citation: BMC Cancer 2020 20:119

    Content type: Research article

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  9. Although shear wave elastography (SWE) is reported to be useful in detecting malignant thyroid nodules, it shows a wide range of cut-off values of elasticity index (EI) in detecting malignant nodules. The caus...

    Authors: Myung Hi Yoo, Hye Jeong Kim, In Ho Choi, Suyeon Park, Sang Jin Kim, Hyeong Kyu Park, Dong Won Byun and Kyoil Suh

    Citation: BMC Cancer 2020 20:118

    Content type: Research article

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  10. Brain metastases from sarcomatous lesions pose a management challenge owing to their rarity and the histopathological heterogeneity. Prognostic indices such as the Graded Prognostic Assessment (GPA) index have...

    Authors: Anna Patrikidou, Loic Chaigneau, Nicolas Isambert, Kyriaki Kitikidou, Ryan Shanley, Isabelle Ray-Coquard, Thibaud Valentin, Bettina Malivoir, Maryline Laigre, Jacques-Olivier Bay, Laurence Moureau-Zabotto, Emmanuelle Bompas, Sophie Piperno-Neumann, Nicolas Penel, Thierry Alcindor, Cécile Guillemet…

    Citation: BMC Cancer 2020 20:117

    Content type: Research article

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  11. Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-associated deaths and a majority of its histological type is manifested as serous ovarian cancer (SOC). In this study, we investigat...

    Authors: Yijing He, Ting Li, Jue Liu, Qiong Ou and Junlin Zhou

    Citation: BMC Cancer 2020 20:116

    Content type: Research article

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  12. The aim of this study was to evaluate the efficacy and safety of nab-paclitaxel plus cisplatin in chemotherapy-naïve patients with advanced non-small-cell lung cancer (NSCLC).

    Authors: Yoshihiro Hattori, Yuko Kono, Shoichi Itoh, Takako Inoue, Yoshiko Urata, Yoshitaka Kawa, Rie Tohnai, Toru Kumagai, Kazumi Nishino, Ryuji Uozumi, Satoshi Morita, Shunichi Negoro, Fumio Imamura and Miyako Satouchi

    Citation: BMC Cancer 2020 20:115

    Content type: Research article

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  13. The HER2 extracellular domain shed in blood (HER2ECD) is reported to rise and fall in parallel with HER2+ breast cancer behavior. In this study, we evaluated the clinical relevance of plasma HER2ECD values in pat...

    Authors: Serenella Eppenberger-Castori, Dirk Klingbiel, Thomas Ruhstaller, Daniel Dietrich, Daniel Alexander Rufle, Karin Rothgiesser, Olivia Pagani and Beat Thürlimann

    Citation: BMC Cancer 2020 20:114

    Content type: Research article

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  14. Soluble Fms-like tyrosine kinase-1 (sFLT1) as an anti-angiogenic factor is abundantly expressed in placental trophoblasts. Choriocarcinoma, a malignant tumor derived from trophoblasts, is known to be highly an...

    Authors: Tadashi Sasagawa, Atsushi Jinno-Oue, Takeshi Nagamatsu, Kazuki Morita, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Tomoyuki Fujii and Masabumi Shibuya

    Citation: BMC Cancer 2020 20:112

    Content type: Research article

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  15. Invasive pancreatic neoplasms have a high propensity for recurrence even after curative resection. Recently, patients who underwent pancreatectomy have an opportunity of undergoing secondary pancreatic resecti...

    Authors: Shigetsugu Takano, Hideyuki Yoshitomi, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Takashi Mishima, Eri Nakadai, Masaru Miyazaki and Masayuki Ohtsuka

    Citation: BMC Cancer 2020 20:111

    Content type: Research article

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  16. TP53 mutations occur in only about 3% of primary and 10–20% of relapse B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). However, alternative mechanisms may contribute to functionally impairing the p53 pa...

    Authors: Lixian Oh, Pierre Hainaut, Sandrine Blanchet and Hany Ariffin

    Citation: BMC Cancer 2020 20:110

    Content type: Research article

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  17. This study aims to understand the factors that influence whether patients receive potentially curative treatment for early stage lung cancer. A key question was whether indigenous Māori patients were less like...

    Authors: Ross Lawrenson, Chunhuan Lao, Leonie Brown, Lucia Moosa, Lynne Chepulis, Rawiri Keenan, Jacquie Kidd, Karen Middleton, Paul Conaglen, Charles de Groot, Denise Aitken and Janice Wong

    Citation: BMC Cancer 2020 20:109

    Content type: Research article

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  18. Colorectal cancer (CRC) in patients aged under 55 years is on the rise, constituting approximately 10% of cases. Our aim was to determine the survival and clinico-pathological details of young-onset CRC (yCRC)...

    Authors: Sarah Perrott, Kirsten Laurie, Kirsten Laws, Annie Johnes, Zosia Miedzybrodzka and Leslie Samuel

    Citation: BMC Cancer 2020 20:108

    Content type: Research article

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  19. Increasing studies have demonstrated that long non-coding RNAs (lncRNAs) play an important role in tumor progression. However, the potential biological functions and clinical importance of Linc01234 in oral sq...

    Authors: Deyu Liu, Xinchun Jian, Pu Xu, Rong Zhu and Yuan Wang

    Citation: BMC Cancer 2020 20:107

    Content type: Research article

    Published on:

  20. Solitary pulmonary nodules (SPNs) is a common radiographic finding and require further evaluation because of the possibility of lung cancer. This study aimed to determine the sensitivity and specificity of cir...

    Authors: Jian Zheng, Xiong Ye, Yanan Liu, Yuxia Zhao, Mudan He and Hui Xiao

    Citation: BMC Cancer 2020 20:106

    Content type: Research article

    Published on:

  21. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is used in the palliative treatment of peritoneal metastasis. The combination of intraperitoneal and systemic chemotherapy seems rational, and the aim o...

    Authors: Magnus Ploug, Martin Graversen, Per Pfeiffer and Michael Bau Mortensen

    Citation: BMC Cancer 2020 20:105

    Content type: Research article

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  22. Recent studies indicate the benefit of treatment with osimertinib over that with conventional epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) for untreated EGFR-mutated non-small cell lun...

    Authors: Mariko Kogo, Daichi Fujimoto, Kazutaka Hosoya, Kazuma Nagata, Atsushi Nakagawa, Ryo Tachikawa, Daisuke Yamashita, Yuka Kitamura, Yukihiro Imai and Keisuke Tomii

    Citation: BMC Cancer 2020 20:104

    Content type: Research article

    Published on:

  23. Epidermal growth factor receptor (EGFR)-sensitizing mutation, exon 19 deletion consists of several molecular variants. Influences of these variants on clinical response to EGFR tyrosine kinase inhibitors remain e...

    Authors: Nahomi Tokudome, Yasuhiro Koh, Hiroaki Akamatsu, Daichi Fujimoto, Isamu Okamoto, Kazuhiko Nakagawa, Toyoaki Hida, Fumio Imamura, Satoshi Morita and Nobuyuki Yamamoto

    Citation: BMC Cancer 2020 20:103

    Content type: Research article

    Published on:

  24. Neuroblastoma is the most common extracranial solid tumor of childhood. The high rate of recurrence is associated with a low survival rate for patients with high-risk neuroblastoma. There is thus an urgent nee...

    Authors: Yan Su, Lijun Wang, Chiyi Jiang, Zhixia Yue, Hongjun Fan, Huimin Hong, Chao Duan, Mei Jin, Dawei Zhang, Lihua Qiu, Xianfeng Cheng, Zhong Xu and Xiaoli Ma

    Citation: BMC Cancer 2020 20:102

    Content type: Research article

    Published on:

  25. Epidemiological studies on the association between coffee intake and cancer risk have yielded inconsistent results. To summarize and appraise the quality of the current evidence, we conducted an umbrella revie...

    Authors: Long-Gang Zhao, Zhuo-Ying Li, Guo-Shan Feng, Xiao-Wei Ji, Yu-Ting Tan, Hong-Lan Li, Marc J. Gunter and Yong-Bing Xiang

    Citation: BMC Cancer 2020 20:101

    Content type: Research article

    Published on:

  26. The purpose of this study was to investigate the value of wavelet-transformed radiomic MRI in predicting the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) for patients with locally adv...

    Authors: Jiali Zhou, Jinghui Lu, Chen Gao, Jingjing Zeng, Changyu Zhou, Xiaobo Lai, Wenli Cai and Maosheng Xu

    Citation: BMC Cancer 2020 20:100

    Content type: Research article

    Published on:

  27. Gastrointestinal stromal tumor (GIST) initiation and evolution is commonly framed by KIT/PDGFRA oncogenic activation, and in later stages by the polyclonal expansion of resistant subpopulations harboring KIT s...

    Authors: César Serrano, Ana Vivancos, Antonio López-Pousa, Judit Matito, Francesco M. Mancuso, Claudia Valverde, Sergi Quiroga, Stefania Landolfi, Sandra Castro, Cristina Dopazo, Ana Sebio, Anna C. Virgili, María M. Menso, Javier Martín-Broto, Miriam Sansó, Alfonso García-Valverde…

    Citation: BMC Cancer 2020 20:99

    Content type: Research article

    Published on:

  28. Men who have sex with men (MSM) living with HIV are at increased risk for anal cancer. We evaluated satisfaction with first-time anal cancer screening using high resolution anoscopy (HRA) as a cross sectional ...

    Authors: Rebecca G. Nowak, Chinedu H. Nnaji, Wuese Dauda, Andrew Mitchell, Oluwole Olaomi, Paul Jibrin, Trevor A. Crowell, Stefan D. Baral, Nicaise Ndembi, Manhattan E. Charurat, Joel M. Palefsky, Søren M. Bentzen and Kevin J. Cullen

    Citation: BMC Cancer 2020 20:98

    Content type: Research article

    Published on:

  29. For selected locally advanced prostate cancer (PCa) patients, radical prostatectomy (RP) is one of the first-line treatments. We aimed to develop a preoperative nomogram to identify what kinds of patients can ...

    Authors: Xianghong Zhou, Qingyang Ning, Kun Jin, Tao Zhang and Xuelei Ma

    Citation: BMC Cancer 2020 20:97

    Content type: Research article

    Published on:

  30. A decrease in thermogenesis is suspected to be implicated in the energy expenditure reduction during breast cancer treatment. This study aimed to investigate the impact of chemotherapy on the metabolic activit...

    Authors: Angeline Ginzac, Bertrand Barres, Marion Chanchou, Emilie Gadéa, Ioana Molnar, Charles Merlin, Bruno Coudert, Emilie Thivat and Xavier Durando

    Citation: BMC Cancer 2020 20:96

    Content type: Research article

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  31. Neuromedin U (NMU) is a neuropeptide belonging to the neuromedin family. Recently, significant associations between NMU and several cancers have been reported. However, no studies have examined the association...

    Authors: Qiao Li, Lingyu Han, Shengnan Ruan, Shunli Shen, Qinghua Cao, Xiuqin Cai, Yuan Yan, Baogang Peng and Yunpeng Hua

    Citation: BMC Cancer 2020 20:95

    Content type: Research article

    Published on:

  32. Lymphovascular invasion (LVI) is a vital risk factor for prognosis across cancers. We aimed to develop a scoring system for stratifying LVI risk in patients with breast cancer.

    Authors: Ma-yi-di-li Ni-jia-ti, Di-li-a-re-mu Ai-hai-ti, Ai-si-ka-er-jiang Huo-jia, Pa-li-dan-mu Wu-mai-er, A-bu-du-ke-you-mu-jiang A-bu-li-zi, Yu Shi, Nu-er-a-mi-na Rou-zi, Wen-jing Su, Guo-zhao Dai and Mai-he-mi-ti-jiang Da-mo-la

    Citation: BMC Cancer 2020 20:94

    Content type: Research article

    Published on:

  33. Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it is not effective ...

    Authors: Mitsunori Morita, Motohiro Tamiya, Daichi Fujimoto, Akihiro Tamiya, Hidekazu Suzuki, Katsuya Hirano, Yasushi Fukuda, Toshihide Yokoyama, Ryota Kominami, Masaki Kanazu, Junji Uchida, Satoshi Hara, Shuji Yamashita and Hiromi Tomioka

    Citation: BMC Cancer 2020 20:93

    Content type: Research article

    Published on:

  34. Colorectal cancer (CRC) is a major killer. Host immunity is important in tumorigenesis. Direct comparison among IL-36α, IL-36β and IL-36γ in the prognosis of CRC is unclear.

    Authors: Feier Chen, Meng Qu, Feng Zhang, Zhenyu Tan, Qinghua Xia, Brett D. Hambly, Shisan Bao and Kun Tao

    Citation: BMC Cancer 2020 20:92

    Content type: Research article

    Published on:

  35. The standard first- and second- line chemotherapy backbone regimens for metastatic colorectal cancer (mCRC) are 5-fluorouracil (5-FU)/capecitabine-based with addition of irinotecan or oxaliplatin. Until recent...

    Authors: Timothy Iveson, Angela M. Carter, Kai-Keen Shiu, Clare Spooner, Daniel Stevens and Saifee Mullamitha

    Citation: BMC Cancer 2020 20:91

    Content type: Research article

    Published on:

  36. It has been hypothesized that radiotherapy (RT) techniques delivering radiations to larger volumes (IMRT, VMAT) are potentially associated with a higher risk of second primary tumors. The aim of this study was...

    Authors: Milly BUWENGE, Erica SCIROCCO, Francesco DEODATO, Gabriella MACCHIA, Maria NTRETA, Silvia BISELLO, Giambattista SIEPE, Savino CILLA, Anna Rita ALITTO, Vincenzo VALENTINI, Lidia STRIGARI, Alessio G. MORGANTI and Silvia CAMMELLI

    Citation: BMC Cancer 2020 20:90

    Content type: Research article

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  37. We compared the efficacy and toxicity of three IC regimens (TPF: taxanes, cisplatin, and 5-fluorouracil; TP: taxanes and cisplatin; and PF: cisplatin and 5-fluorouracil) followed by CCRT in locoregionally adva...

    Authors: Sai-Lan Liu, Xue-Song Sun, Hao-Jun Xie, Qiu-Yan Chen, Huan-Xin Lin, Hu Liang, Yu-Jing Liang, Xiao-Yun Li, Jin-Jie Yan, Chao Lin, Zhen-Chong Yang, Shan-Shan Guo, Li-Ting Liu, Qing-Nan Tang, Yu-Yun Du, Lin-Quan Tang…

    Citation: BMC Cancer 2020 20:89

    Content type: Research article

    Published on:

  38. This planning study compares different radiotherapy techniques for patients with pituitary adenoma, including flatness filter free mode (FFF), concerning plan quality and secondary malignancies for potentially...

    Authors: Marius Treutwein, Felix Steger, Rainer Loeschel, Oliver Koelbl and Barbara Dobler

    Citation: BMC Cancer 2020 20:88

    Content type: Research article

    Published on:

  39. Following publication of the original article [1], an error was reported in the author group. The correct author group should read as follows:

    Authors: Anita Feller, Katarina L. Matthes, Andrea Bordoni, Christine Bouchardy, Jean-Luc Bulliard, Christian Herrmann, Isabelle Konzelmann, Manuela Maspoli, Mohsen Mousavi, Sabine Rohrmann, Katharina Staehelin and Volker Arndt

    Citation: BMC Cancer 2020 20:87

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:51

  41. Interrogation of site-specific CpG methylation in circulating tumor DNAs (ctDNAs) has been employed in a number of studies for early detection of breast cancer (BrCa). In many of these studies, the markers wer...

    Authors: Manny D. Bacolod, Jianmin Huang, Sarah F. Giardina, Philip B. Feinberg, Aashiq H. Mirza, Alexander Swistel, Steven A. Soper and Francis Barany

    Citation: BMC Cancer 2020 20:85

    Content type: Research article

    Published on:

  42. Cancer subtyping has mainly relied on pathological and molecular means. Massively parallel sequencing-enabled subtyping requires genomic markers to be developed based on global features rather than individual ...

    Authors: Zhenggang Wu, Xi Long, Shui Ying Tsang, Taobo Hu, Jian-Feng Yang, Wai Kin Mat, Hongyang Wang and Hong Xue

    Citation: BMC Cancer 2020 20:84

    Content type: Research article

    Published on:

  43. Gene expression profiling has consistently identified three molecular subtypes of lung adenocarcinoma that have prognostic implications. To facilitate stratification of patients with this disease into similar ...

    Authors: Roberto Ruiz-Cordero, Junsheng Ma, Abha Khanna, Genevieve Lyons, Waree Rinsurongkawong, Roland Bassett, Ming Guo, Mark J. Routbort, Jianjun Zhang, Ferdinandos Skoulidis, John Heymach, Emily B. Roarty, Zhenya Tang, L. Jeffrey Medeiros, Keyur P. Patel, Rajyalakshmi Luthra…

    Citation: BMC Cancer 2020 20:83

    Content type: Research article

    Published on:

  44. Although the pancreatic ductal adenocarcinoma (PDAC) presents high mortality and metastatic potential, there is a lack of effective therapies and a low survival rate for this disease. This PDAC scenario urges ...

    Authors: Palloma Porto Almeida, Cristina Padre Cardoso and Leandro Martins de Freitas

    Citation: BMC Cancer 2020 20:82

    Content type: Software

    Published on:

  45. Increased usage of genomic risk assessment assays suggests increased reliance on data provided by these assays to guide therapy decisions. The current study aimed to assess the change in treatment decision and...

    Authors: Hatem Soliman, Varsha Shah, Gordan Srkalovic, Reshma Mahtani, Ellis Levine, Blanche Mavromatis, Jayanthi Srinivasiah, Mohamad Kassar, Robert Gabordi, Rubina Qamar, Sarah Untch, Heather M. Kling, Tina Treece and William Audeh

    Citation: BMC Cancer 2020 20:81

    Content type: Research article

    Published on:

  47. Gliomas consist of a heterogeneous group of tumors. This study aimed to report the incidences of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation, 1p19q co-deletion, isocitrate dehydrogenase (ID...

    Authors: Samantha Ya Lyn Ang, Lester Lee, Angela An Qi See, Ting Yao Ang, Beng Ti Ang and Nicolas Kon Kam King

    Citation: BMC Cancer 2020 20:79

    Content type: Research article

    Published on:

  48. Although immediate breast reconstruction has been reported to be oncologically safe, no affirmative study comparing the two reconstruction methods exists. We investigated breast cancer recurrence rates in two ...

    Authors: Jeong Hyun Ha, Ki Yong Hong, Han-Byoel Lee, Hyeong-Gon Moon, Wonshik Han, Dong-Young Noh, Joonho Lim, Sehoon Yoon, Hak Chang and Ung Sik Jin

    Citation: BMC Cancer 2020 20:78

    Content type: Research article

    Published on:

  49. Recently, accumulating evidence has suggested that the aberrant expression of SNHG6 exists in a variety of tumors and has a correlation with poor clinical outcomes across cancer patients. Considering the incon...

    Authors: Si Zhao, Hanlong Zhu, Ruonan Jiao, Xueru Wu, Guozhong Ji and Xiuhua Zhang

    Citation: BMC Cancer 2020 20:77

    Content type: Research article

    Published on:

  50. Carbon ion Radiotherapy for prostate cancer is widely used, however reports are limited from single institute or short follow up. We performed a prospective observational study (GUNMA0702) to evaluate the feas...

    Authors: Hidemasa Kawamura, Nobuteru Kubo, Hiro Sato, Tatsuji Mizukami, Hiroyuki Katoh, Hitoshi Ishikawa, Tatsuya Ohno, Hiroshi Matsui, Kazuto Ito, Kazuhiro Suzuki and Takashi Nakano

    Citation: BMC Cancer 2020 20:75

    Content type: Research article

    Published on:

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