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  1. There are differences in survival between high-and low-grade Upper Tract Urothelial Carcinoma (UTUC). Our study aimed to develop a nomogram to predict overall survival (OS) of patients with high- and low-grade...

    Authors: Mengmeng Wang, Xin Ren, Ge Wang, Xiaomin Sun, Shifeng Tang, Baogang Zhang, Xiaoming Xing, Wenfeng Zhang, Guojun Gao, Jing Du, Shukun Zhang, Lijuan Liu, Xia Zheng, Zhenkun Zhang and Changgang Sun

    Citation: BMC Cancer 2021 21:999

    Content type: Research

    Published on:

  2. Cancer mortality in the U.S. has fallen in recent decades; however, individuals with lower levels of education experienced a smaller decline than more highly educated individuals. This analysis aimed to measur...

    Authors: Alberto Barcelo, Linda Duffett-Leger, Maria Pastor-Valero, Juliana Pereira, Fernando A. B. Colugnati and Edward Trapido

    Citation: BMC Cancer 2021 21:907

    Content type: Research

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  3. Esophageal cancer is a common malignant tumor and its 5-year survival rate is much lower than 30% due to its invasiveness and pronounced metastasis ability, as well as the difficulty in early diagnosis. This s...

    Authors: Rong Li, Xing-Feng Pang, Zhi-Guang Huang, Li-Hua Yang, Zhi-Gang Peng, Jie Ma and Rong-Quan He

    Citation: BMC Cancer 2021 21:996

    Content type: Research

    Published on:

  4. Many clinical trials have assessed the effect and safety of monoclonal antibodies (MAbs) in combination with proteasome inhibitors or immunomodulators plus dexamethasone/prednisone for the treatment of multipl...

    Authors: Wu Ye, Xia Wu, Xiaoyan Liu, Xue Zheng, Jili Deng and Yuping Gong

    Citation: BMC Cancer 2021 21:994

    Content type: Research article

    Published on:

  5. Selinexor is an oral, selective nuclear export inhibitor. STORM was a phase 2b, single-arm, open-label, multicenter trial of selinexor with low dose dexamethasone in patients with penta-exposed relapsed/refrac...

    Authors: Gabriel Tremblay, Patrick Daniele, Janis Breeze, Lingling Li, Jatin Shah, Sharon Shacham, Michael Kauffman, Monika Engelhardt, Ajaj Chari, Ajay Nooka, Dan Vogl, Maria Gavriatopoulou, Meletios-Athanasios Dimopoulos, Paul Richardson, Noa Biran, David Siegel…

    Citation: BMC Cancer 2021 21:993

    Content type: Research article

    Published on:

  6. Syntaxin4 (STX4) gene encodes the protein STX4, a member of soluble N-ethylmaleimide-sensitive factor attachment protein receptors protein, playing a vital role in cell invadopodium formation and invasion, whi...

    Authors: Lishan He, Huiming Jiang, Zhenqiang Lai, Zhixiong Zhong and Zhanqin Huang

    Citation: BMC Cancer 2021 21:992

    Content type: Research

    Published on:

  7. The study here investigated quantitative ultrasound (QUS) parameters to assess tumour response to ultrasound-stimulated microbubbles (USMB) and hyperthermia (HT) treatment in vivo. Mice bearing prostate cancer xe...

    Authors: Deepa Sharma, Laurentius Oscar Osapoetra, Mateusz Faltyn, Anoja Giles, Martin Stanisz and Gregory J. Czarnota

    Citation: BMC Cancer 2021 21:991

    Content type: Research

    Published on:

  8. A low tissue oxygen level, < 1% O2, is a typical characteristic inside of solid tumors in head and neck cancer (HNSCC) affecting a wide array of cell populations, such as macrophages. However, the mechanisms of h...

    Authors: Tamiko Ishizu, Dominik Eichin, Artur Padzik, Sanni Tuominen, Reidar Grénman, Marko Salmi, Tove J. Grönroos and Johanna M. Tuomela

    Citation: BMC Cancer 2021 21:990

    Content type: Research

    Published on:

  9. Gastrointestinal tumors are a leading cause of mortality worldwide. As shown in our previous study, miR-1290 is overexpressed in colorectal cancer (CRC) and promotes tumor progression. We therefore aimed to ex...

    Authors: Liyi Xu, Yangke Cai, Xiao Chen, Yongliang Zhu and Jianting Cai

    Citation: BMC Cancer 2021 21:989

    Content type: Research article

    Published on:

  10. In clinical studies, it has been observed that esophageal cancer (EC) patient prognosis can be very different even for those patients with tumors of the same TNM stage. Tumor length has been analysed as a poss...

    Authors: Zhao Yang Wang, Yuan Zhu Jiang, Wen Xiao, Xian Biao Xue, Xiang Wei Zhang and Lin Zhang

    Citation: BMC Cancer 2021 21:988

    Content type: Research article

    Published on:

  11. Pneumocystis jirovecii pneumonia (PCP)-related risk factors among patients with solid tumors are not completely defined. Thus, we aimed to characterize PCP cases with underlying solid tumors, to highlight the fac...

    Authors: Koichi Takeda, Sohei Harada, Brian Hayama, Kosuke Hoashi, Taisuke Enokida, Toshiharu Sasaki, Koh Okamoto, Kenji Nakano and Daisuke Ohkushi

    Citation: BMC Cancer 2021 21:987

    Content type: Research article

    Published on:

  12. Prosthesis-related complications, after knee reconstruction with endoprosthesis during operation for tumors around the knee, remain an unresolved problem which necessitate a revision or even an amputational su...

    Authors: Cheng-gang Pang, Xiong-gang Yang, Yun-long Zhao, Yan-cheng Liu and Yong-cheng Hu

    Citation: BMC Cancer 2021 21:986

    Content type: Research article

    Published on:

  13. Lung cancer incidence and prevalence is increasing worldwide and there is a focus on prevention, early detection, and development of new treatments which will impact the epidemiological patterns of lung cancer...

    Authors: Erik Jakobsen, Karen Ege Olsen, Mette Bliddal, Malene Hornbak, Gitte F. Persson and Anders Green

    Citation: BMC Cancer 2021 21:985

    Content type: Research

    Published on:

  14. Acute lymphoid leukaemia (ALL) is the commonest childhood cancer whose incidence is rising in many nations. In the USA, between 1975 and 2016, ALL rates (ALLRs) rose 93.51% from 1.91 to 3.70/100,000 <  20 year...

    Authors: Albert Stuart Reece and Gary Kenneth Hulse

    Citation: BMC Cancer 2021 21:984

    Content type: Research article

    Published on:

  15. The aim of this study was to assess the diagnostic utility of metabolic parameters on fluorine-18-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET)/computed tomography (CT) for predicting lymph n...

    Authors: Keita Nakanishi, Shota Nakamura, Tomoshi Sugiyama, Yuka Kadomatsu, Harushi Ueno, Masaki Goto, Naoki Ozeki, Takayuki Fukui, Shingo Iwano and Toyofumi Fengshi Chen-Yoshikawa

    Citation: BMC Cancer 2021 21:983

    Content type: Research

    Published on:

  16. B vitamins and methionine are essential substrates in the one-carbon metabolism pathway involved in DNA synthesis and methylation. They may have essential roles in cancer development. We aimed to evaluate the ...

    Authors: Paramita Khairan, Tomotaka Sobue, Ehab Salah Eshak, Ling Zha, Tetsuhisa Kitamura, Norie Sawada, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Taichi Shimazu, Hiroyasu Iso and Shoichiro Tsugane

    Citation: BMC Cancer 2021 21:982

    Content type: Research

    Published on:

  17. Paclitaxel (Taxol) is a microtubule-stabilizing drug used to treat several solid tumors, including ovarian, breast, non-small cell lung, and pancreatic cancers. The current treatment of ovarian cancer is chemo...

    Authors: Celina Amaya, Shihua Luo, Julio Baigorri, Rogelio Baucells, Elizabeth R. Smith and Xiang-Xi Xu

    Citation: BMC Cancer 2021 21:981

    Content type: Research

    Published on:

  18. Ubiquitously transcribed tetratricopeptide repeat on chromosome X (UTX) has been identified as a histone 3 lysine 27 (H3K27) demethylase and acted as a tumor suppressor gene or oncogenic function. The current ...

    Authors: Yen-Hao Chen, Chang-Han Chen, Chih-Yen Chien, Yan-Ye Su, Sheng-Dean Luo and Shau-Hsuan Li

    Citation: BMC Cancer 2021 21:979

    Content type: Research

    Published on:

  19. The efficacy and safety of bevacizumab-containing chemotherapy for patients with metastatic duodenal and jejunal adenocarcinoma (mDJA) are unclear. The present study aimed to evaluate the efficacy of bevacizum...

    Authors: Takahiro Amano, Hideki Iijima, Shinichiro Shinzaki, Taku Tashiro, Shuko Iwatani, Mizuki Tani, Yuriko Otake, Takeo Yoshihara, Aya Sugimoto, Satoshi Egawa, Shinjiro Yamaguchi, Kazuo Kinoshita, Manabu Araki, Motohiro Hirao, Yuko Sakakibara, Satoshi Hiyama…

    Citation: BMC Cancer 2021 21:978

    Content type: Research

    Published on:

  20. There is a lack of useful diagnostic tools to identify EGFR mutated NSCLC patients with long-term survival. This study develops a prognostic model using real world data to assist clinicians to predict survival...

    Authors: Lourdes Gutiérrez, Ana Royuela, Enric Carcereny, Rafael López-Castro, Delvys Rodríguez-Abreu, Bartomeu Massuti, José Luis González-Larriba, Rosario García-Campelo, Joaquim Bosch-Barrera, María Guirado, Carlos Camps, Manuel Dómine, Reyes Bernabé, Joaquín Casal, Juana Oramas, Ana Laura Ortega…

    Citation: BMC Cancer 2021 21:977

    Content type: Research

    Published on:

  21. Optic nerve astrocytomas (ONAs) are neurological neoplasms in the central nervous system (CNS), and they have the highest incidence rate among all the tumor types in the visual pathway. In this study, we condu...

    Authors: Mingui Zhang, Tao Chen and Yisheng Zhong

    Citation: BMC Cancer 2021 21:976

    Content type: Research

    Published on:

  22. Breast cancer in men accounts for fewer than 1 % of all breast cancer cases diagnosed in men and women. Genes which predispose to male breast cancer include BRCA1 and BRCA2. The role of other genes is less clear....

    Authors: Marek Szwiec, Joanna Tomiczek-Szwiec, Wojciech Kluźniak, Dominika Wokołorczyk, Karolina Osowiecka, Robert Sibilski, Małgorzata Wachowiak, Jacek Gronwald, Helena Gronwald, Jan Lubiński, Cezary Cybulski, Steven A. Narod and Tomasz Huzarski

    Citation: BMC Cancer 2021 21:975

    Content type: Research article

    Published on:

  23. This study compared the long-term efficacy of different durations of adjuvant chemotherapy for patients with gastric cancer after radical gastrectomy with D2 lymphadenectomy.

    Authors: Lei Chen, Chenghai Zhang, Zhendan Yao, Ming Cui, Jiadi Xing, Hong Yang, Nan Zhang, Maoxing Liu, Kai Xu, Fei Tan, Yuzhe Li, Beihai Jiang and Xiangqian Su

    Citation: BMC Cancer 2021 21:974

    Content type: Research article

    Published on:

  24. The prognosis of advanced laryngeal cancer is unfavorable despite advances in multidisciplinary therapy. Dendritic cells (DCs) play a central role in antitumor immunity. Tumor-infiltrating CD1a+ DCs have been rep...

    Authors: Akimichi Minesaki, Keita Kai, Yuichiro Kuratomi and Shinichi Aishima

    Citation: BMC Cancer 2021 21:973

    Content type: Research article

    Published on:

  25. Tumor mutation burden is an emerging biomarker for immunotherapy. Although several clinical trials for immunotherapy in lymphoma have been carried out, the mutation burden of various lymphomas is not well know...

    Authors: Junhun Cho, Sang Eun Yoon, Seok Jin Kim, Young Hyeh Ko and Won Seog Kim

    Citation: BMC Cancer 2021 21:972

    Content type: Research

    Published on:

  26. Photodynamic therapy with a photosensitizer such as protoporphyrin-IX, a light sensitive metabolite of heme synthesis, is a highly selective treatment for various carcinomas. In previous studies, we found a si...

    Authors: Bernhard Gillissen, Antje Richter, Frank Essmann and Wolfgang Kemmner

    Citation: BMC Cancer 2021 21:971

    Content type: Research article

    Published on:

  27. Ovarian cancer is the leading cause of death among gynecological malignancies. Immunotherapy has demonstrated potential effects in ovarian cancer. However, few studies on immune-related prognostic signatures i...

    Authors: Rongjia Su, Chengjuan Jin, Lina Zhou, Yannan Cao, Menghua Kuang, Linxia Li and Jiangdong Xiang

    Citation: BMC Cancer 2021 21:970

    Content type: Research article

    Published on:

  28. Treatment with immune checkpoint inhibitors (ICIs) targeting CTLA-4 and the PD-1/PD-L1 axis is effective against many cancer types. However, due in part to unresponsiveness or acquired resistance, not all pati...

    Authors: Reid P. Bissonnette, Rosemary M. Cesario, Bob Goodenow, Farbod Shojaei and Mireille Gillings

    Citation: BMC Cancer 2021 21:969

    Content type: Research

    Published on:

  29. The advent of immune checkpoint inhibitors (ICIs) therapy has resulted in significant survival benefits in patients with non-small-cell lung cancer (NSCLC) without increasing toxicity. However, the utilisation...

    Authors: Chengdi Wang, Jingwei Li, Qiran Zhang, Jiayang Wu, Yuxuan Xiao, Lujia Song, Hanlin Gong and Yalun Li

    Citation: BMC Cancer 2021 21:968

    Content type: Research article

    Published on:

  30. Patients with breast cancer who overexpress the human epidermal growth factor receptor 2 (HER2) and subsequently develop brain metastasis (BM) typically experience poor quality of life and low survival. We con...

    Authors: Michelle D. Hackshaw, Heather E. Danysh, Mackenzie Henderson, Eric Wang, Nora Tu, Zahidul Islam, Amy Ladner, Mary E. Ritchey and Maribel Salas

    Citation: BMC Cancer 2021 21:967

    Content type: Research article

    Published on:

  31. Adherence to colorectal cancer screening in the United States is suboptimal, particularly in medically underserved populations due to significant barriers to care. Unique accessible, low-cost, and non-invasive...

    Authors: Stephanie Ioannou, Kyle Sutherland, Daniel A. Sussman and Amar R. Deshpande

    Citation: BMC Cancer 2021 21:966

    Content type: Research article

    Published on:

  32. The main aim of this study was to ascertain the effectiveness of ultrasound-guided fine needle aspiration cytology (US-FNAC) in the diagnosis of para-aortic lymph node (PALN) metastasis in uterine cervical can...

    Authors: Junping Liu, Xin Liu, Zhengying Guo, Xiaojuan Lv, Weimin Mao, Dong Xu and Lijing Wang

    Citation: BMC Cancer 2021 21:964

    Content type: Research

    Published on:

  33. Receiving a cancer diagnosis may trigger immediate fatal non-cancer health outcomes in addition to dying of cancer itself. We aim to investigate the full pattern of non-cancer deaths in patients within a year ...

    Authors: Pengcheng Yang, Yongqiang Zheng, Jiayuan Chen, Haotian Ma, Kaixu Yu, Ying Chen, Yun Yang and Bian Wu

    Citation: BMC Cancer 2021 21:963

    Content type: Research

    Published on:

  34. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in the world owing to limitations in its prognosis. The current prognosis approaches include radiological examination and detection o...

    Authors: Rajinder Gupta, Jos Kleinjans and Florian Caiment

    Citation: BMC Cancer 2021 21:962

    Content type: Research

    Published on:

  35. Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with a poor prognosis. Given the limited treatment options, prognostic assessment of ACC is increasingly crucial. In this study, we aim to ass...

    Authors: Fuxun Zhang, Zhihong Liu, Jiayu Liang, Shengzhuo Liu, Kan Wu, Fan Zhang, Chuan Zhou, Yiping Lu, Yuchun Zhu and Xianding Wang

    Citation: BMC Cancer 2021 21:961

    Content type: Research article

    Published on:

  36. The impact of smokeless tobacco (SLT) use on the risk of oral cavity cancer (OCC) has been confirmed; however, the sex-based difference in this association remains inconclusive. Therefore, this study aimed to ...

    Authors: Guangyan Mu, Jiayi Wang, Zhiyan Liu, Hanxu Zhang, Shuang Zhou, Qian Xiang and Yimin Cui

    Citation: BMC Cancer 2021 21:960

    Content type: Research article

    Published on:

  37. It is very necessary to implement gastric cancer screening in China to reduce the mortality of gastric cancer, but there are no national screening guidelines and programs. Understanding of individual preferenc...

    Authors: Hui-qin Li, Hui Xue, Hua Yuan, Guang-ying Wan and Xiu-ying Zhang

    Citation: BMC Cancer 2021 21:959

    Content type: Research article

    Published on:

  38. The advanced hepatocellular carcinoma (HCC), such as the recurrent tumor after liver transplantation (LT), is an obstacle of HCC treatment. The aim of this study was to discover the underlying mechanism of HCC...

    Authors: Tao Liu, Qiao Shi, Lei Yang, Shusen Wang, Hongli Song, Zhenglu Wang, Xinnv Xu, Hongsheng Liu, Hong Zheng and Zhongyang Shen

    Citation: BMC Cancer 2021 21:957

    Content type: Research

    Published on:

  39. The improved prognosis of classic Hodgkin lymphoma (cHL) has been accompanied by elevated risks of non–cancer-specific death (non-CSD). The aim of this study was to verify the occurrence of non-CSD and its eff...

    Authors: Jie Gao, Yingying Chen, Pengqiang Wu, Fujue Wang, Huan Tao, Qianqing Shen, Shuoting Wang, Shuaige Gong, Xue Zhang, Zhencang Zhou, Xianmin Song and Yongqian Jia

    Citation: BMC Cancer 2021 21:955

    Content type: Research

    Published on:

  40. Colorectal cancer (CRC) is the most diagnosed cancer among males and third among females in Saudi Arabia, with up to two-third diagnosed at advanced stage. The objective of our study was to estimate CRC surviv...

    Authors: Mesnad Alyabsi, Fouad Sabatin, Majed Ramadan and Abdul Rahman Jazieh

    Citation: BMC Cancer 2021 21:954

    Content type: Research

    Published on:

  41. Abnormal activation of the coagulation system has been reported in patients with malignancies, but its prognostic significance in biliary tract cancer (BTC) remains unclear. This study aims to analyze and comp...

    Authors: Xindi Ke, Bao Jin, Wen You, Yang Chen, Haifeng Xu, Haitao Zhao, Xin Lu, Xinting Sang, Shouxian Zhong, Huayu Yang, Yilei Mao and Shunda Du

    Citation: BMC Cancer 2021 21:953

    Content type: Research

    Published on:

  42. Cervical cancer (CC) incidence remains unacceptably high in Côte d’Ivoire. In an effort to prevent this malignant condition, a national CC screening program has been scaled up in the country. This study aimed ...

    Authors: Simon P. Boni, Franck Gnahatin, Jean-Claude Comoé, Boris Tchounga, Didier Ekouevi, Apollinaire Horo, Innocent Adoubi and Antoine Jaquet

    Citation: BMC Cancer 2021 21:952

    Content type: Research

    Published on:

  43. The gasdermin E gene (GSDME, also known as DFNA5) is mutated in familial aging-related hearing loss. Recent studies have also revealed that the expression of DFNA5 is suppressed in many cancer types; however, lit...

    Authors: Zhiguo Liu, Hongyan Liu, Qian Dong, Hongyu Li, Bin Zhang, Yufeng Liu, Limei Zhong and Haikuo Tang

    Citation: BMC Cancer 2021 21:951

    Content type: Research

    Published on:

  44. Neuroblastoma (NB) is one of the most frequently diagnosed tumors in infants. NB is a neuroendocrine tumor type with various characteristics and features, and with diverse outcome. The most malignant NBs have ...

    Authors: Arman Romiani, Johan Spetz, Emman Shubbar, Dan E. Lind, Bengt Hallberg, Ruth H. Palmer and Eva Forssell-Aronsson

    Citation: BMC Cancer 2021 21:950

    Content type: Research

    Published on:

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