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  1. Chemotherapeutics can stimulate immune antitumor response by inducing immunogenic cell death (ICD), which is activated by Damage-Associated Molecular Patterns (DAMPs) like the exposure of calreticulin (CRT) on...

    Authors: José Ignácio Gonzalez Solari, Eduardo Filippi-Chiela, Emily Salles Pilar, Vitória Nunes, Esteban Alberto Gonzalez, Fabrício Figueiró, Cristiano Feijó Andrade and Fábio Klamt

    Citation: BMC Cancer 2020 20:474

    Content type: Research article

    Published on:

  2. Self-sampling for HPV testing, as an alternative to the conventional speculum based sampling, is highly acceptable to women of screening ages. The aim of this study was to describe older women’s (60 to 75 year...

    Authors: Ruth S. Hermansson, Matts Olovsson, Catharina Gustavsson and Annika Kristina Lindström

    Citation: BMC Cancer 2020 20:473

    Content type: Research article

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  3. Acute myeloid leukemia (AML) is a common hematopoietic malignancy that has a high relapse rate, and the number of regulatory T cells (Tregs) in AML patients is significantly increased. The aim of this study wa...

    Authors: Yuling Wan, Congxiao Zhang, Yingxi Xu, Min Wang, Qing Rao, Haiyan Xing, Zheng Tian, Kejing Tang, Yingchang Mi, Ying Wang and Jianxiang Wang

    Citation: BMC Cancer 2020 20:472

    Content type: Research article

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  4. Glutamine serves as an important nutrient with many cancer types displaying glutamine dependence. Following cellular uptake glutamine is converted to glutamate in a reaction catalysed by mitochondrial glutamin...

    Authors: Dean C. Singleton, Anne-Lise Dechaume, Pamela M. Murray, William P. Katt, Bruce C. Baguley and Euphemia Y. Leung

    Citation: BMC Cancer 2020 20:470

    Content type: Research article

    Published on:

  5. Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progres...

    Authors: Maxine G. B. Tran, Becky A. S. Bibby, Lingjian Yang, Franklin Lo, Anne Y. Warren, Deepa Shukla, Michelle Osborne, James Hadfield, Thomas Carroll, Rory Stark, Helen Scott, Antonio Ramos-Montoya, Charlie Massie, Patrick Maxwell, Catharine M. L. West, Ian G. Mills…

    Citation: BMC Cancer 2020 20:469

    Content type: Research article

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  6. Neoadjuvant chemotherapy is a promising treatment option for potential resectable gastric cancer, but patients’ responses vary. We aimed to develop and validate a radiomics score (rad_score) to predict treatme...

    Authors: Kai-Yu Sun, Hang-Tong Hu, Shu-Ling Chen, Jin-Ning Ye, Guang-Hua Li, Li-Da Chen, Jian-Jun Peng, Shi-Ting Feng, Yu-Jie Yuan, Xun Hou, Hui Wu, Xin Li, Ting-Fan Wu, Wei Wang and Jian-Bo Xu

    Citation: BMC Cancer 2020 20:468

    Content type: Research article

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  7. The mitochondrial fission protein, Dynamin related protein 1 (Drp1), and its upstream protein calcium/calmodulin–dependent protein kinase I (CaMKI) play a critical role in chemoresistance in ovarian cancer (OV...

    Authors: Hideaki Tsuyoshi, Makoto Orisaka, Yuko Fujita, Meshach Asare-Werehene, Benjamin K. Tsang and Yoshio Yoshida

    Citation: BMC Cancer 2020 20:467

    Content type: Research article

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  8. There are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasi...

    Authors: Espen Thiis-Evensen, Amalie Christine Poole, Hong-Thien Thi Nguyen and Jon Sponheim

    Citation: BMC Cancer 2020 20:466

    Content type: Research article

    Published on:

  9. The preoperative peripheral blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR) have been reported to be associated with the prognosis of various cancer...

    Authors: Rong Cong, Fanfei Kong, Jian Ma, Qing Li, Qijun Wu and Xiaoxin Ma

    Citation: BMC Cancer 2020 20:464

    Content type: Research article

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  10. Urothelial cancer (UC) includes carcinomas of the bladder, ureters, and renal pelvis. New treatments and biomarkers of UC emerged in this decade. To identify the key information in a vast amount of literature ...

    Authors: Hsuan-Jen Lin, Phillip C.-Y. Sheu, Jeffrey J. P. Tsai, Charles C. N. Wang and Che-Yi Chou

    Citation: BMC Cancer 2020 20:462

    Content type: Research article

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  11. Venous thromboembolism (VTE) is highly prevalent in cancer patients and can cause severe morbidity. VTE treatment is essential, but anticoagulation increases the risk of major bleeding. The purpose was to eval...

    Authors: Jennifer Howlett, Eric Benzenine, Jonathan Cottenet, Pascal Foucher, Philippe Fagnoni and Catherine Quantin

    Citation: BMC Cancer 2020 20:461

    Content type: Research article

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  12. Individuals with pathogenic germline variants in DNA mismatch repair (MMR) genes are at increased risk of developing colorectal, endometrial and other cancers (Lynch syndrome, LS). While previous studies have ...

    Authors: Karolin Bucksch, Silke Zachariae, Stefan Aretz, Reinhard Büttner, Elke Holinski-Feder, Stefanie Holzapfel, Robert Hüneburg, Matthias Kloor, Magnus von Knebel Doeberitz, Monika Morak, Gabriela Möslein, Jacob Nattermann, Claudia Perne, Nils Rahner, Wolff Schmiegel, Karsten Schulmann…

    Citation: BMC Cancer 2020 20:460

    Content type: Research article

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  13. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) copy number alterations and unbalanced gene recombination events have been reported to occur in breast cancer. Importantly, LRIG1 loss was recently s...

    Authors: Mahmood Faraz, Andreas Tellström, Christina Edwinsdotter Ardnor, Kjell Grankvist, Lukasz Huminiecki, Björn Tavelin, Roger Henriksson, Håkan Hedman and Ingrid Ljuslinder

    Citation: BMC Cancer 2020 20:459

    Content type: Research article

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  14. Although cancer-related fatigue (CRF) has gained increased attention in the past decade, therapy remains a challenge. Treatment programs are more likely to be effective if the needs and interests of the person...

    Authors: Claudia Canella, Michael Mikolasek, Matthias Rostock, Matthias Guckenberger, Josef Jenewein, Esther Linka, Claudia Six, Sarah Stoll, Roger Stupp and Claudia M. Witt

    Citation: BMC Cancer 2020 20:458

    Content type: Research article

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  15. Patients diagnosed with metastatic castration-refractory prostate cancer (mCRPC) rely on a limited number of therapeutic agents resulting in a median survival of 2–3 years. A subgroup of those patients with mC...

    Authors: Charlien Berghen, Steven Joniau, Kato Rans, Gaëtan Devos, Kenneth Poels, Koen Slabbaert, Herlinde Dumez, Maarten Albersen, Karolien Goffin, Karin Haustermans and Gert De Meerleer

    Citation: BMC Cancer 2020 20:457

    Content type: Study protocol

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  16. Despite the embedding of bladder cancer management in European guidelines, large variation in clinical practice exists for applied diagnostics and treatments. This variation may affect patients’ outcomes inclu...

    Authors: T. M. Ripping, L. A. Kiemeney, L. M. C. van Hoogstraten, J. A. Witjes and K. K. H. Aben

    Citation: BMC Cancer 2020 20:455

    Content type: Study protocol

    Published on:

  17. Activated eosinophils have been deemed to affect carcinogenesis and tumor progression via various mechanisms in tumor microenvironment. However, the prognostic role of tumor-associated tissue eosinophilia (TAT...

    Authors: Guoming Hu, Shimin Wang, Kefang Zhong, Feng Xu, Liming Huang, Wei Chen and Pu Cheng

    Citation: BMC Cancer 2020 20:454

    Content type: Research article

    Published on:

  18. As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an ad...

    Authors: Kristiina Vuolukka, Päivi Auvinen, Jan-Erik Palmgren, Sirpa Aaltomaa and Vesa Kataja

    Citation: BMC Cancer 2020 20:453

    Content type: Research article

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  19. UK national guidelines suggest women at high-risk of breast cancer should be offered more frequent screening or preventative medications. Currently, only 1 in 6 high-risk women are identified. One route to ide...

    Authors: Victoria G. Woof, Helen Ruane, David P. French, Fiona Ulph, Nadeem Qureshi, Nasaim Khan, D. Gareth Evans and Louise S. Donnelly

    Citation: BMC Cancer 2020 20:452

    Content type: Research article

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  20. The aim of the current study was to report a single-institution experience using breast-conserving surgery after neoadjuvant chemotherapy (NACT), focusing on the association between microscopic resection margi...

    Authors: Joseph Lin, Kuo-Juei Lin, Yu-Fen Wang, Ling-Hui Huang, Sam Li-Sheng Chen and Dar-Ren Chen

    Citation: BMC Cancer 2020 20:451

    Content type: Research article

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  21. The T2-FLAIR mismatch sign is an imaging finding highly suggestive of isocitrate dehydrogenase mutated (IDH-mut) 1p19q non-codeleted (non-codel) gliomas (astrocytomas). In previous studies, it has shown excellent...

    Authors: Alba Corell, Sandra Ferreyra Vega, Nickoleta Hoefling, Louise Carstam, Anja Smits, Thomas Olsson Bontell, Isabella M. Björkman-Burtscher, Helena Carén and Asgeir Store Jakola

    Citation: BMC Cancer 2020 20:450

    Content type: Research article

    Published on:

  22. There is no established second-line treatment after failure of gemcitabine plus nab-paclitaxel (GnP) therapy for metastatic pancreatic cancer (MPC). The purpose of this study was to evaluate the efficacy and t...

    Authors: Masashi Sawada, Akiyoshi Kasuga, Takafumi Mie, Takaaki Furukawa, Takanobu Taniguchi, Koshiro Fukuda, Yuto Yamada, Tsuyoshi Takeda, Ryo Kanata, Masato Matsuyama, Takashi Sasaki, Masato Ozaka and Naoki Sasahira

    Citation: BMC Cancer 2020 20:449

    Content type: Research article

    Published on:

  23. Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.

    Authors: Paula Whitmire, Cassandra R. Rickertsen, Andrea Hawkins-Daarud, Eduardo Carrasco Jr, Julia Lorence, Gustavo De Leon, Lee Curtin, Spencer Bayless, Kamala Clark-Swanson, Noah C. Peeri, Christina Corpuz, Christine Paula Lewis-de los Angeles, Bernard R. Bendok, Luis Gonzalez-Cuyar, Sujay Vora, Maciej M. Mrugala…

    Citation: BMC Cancer 2020 20:447

    Content type: Research article

    Published on:

  24. Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion. In cancer it was postulated that the fusion...

    Authors: Sera Selina Fahlbusch, Silvia Keil, Jörg T. Epplen, Kurt S. Zänker and Thomas Dittmar

    Citation: BMC Cancer 2020 20:446

    Content type: Research article

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  25. While combinations of immune checkpoint (ICP) inhibitors and neo-adjuvant chemotherapy (NAC) have begun testing in patients with breast cancer (BC), the effects of chemotherapy on ICP expression in circulating...

    Authors: Robert Wesolowski, Andrew Stiff, Dionisia Quiroga, Christopher McQuinn, Zaibo Li, Hiroaki Nitta, Himanshu Savardekar, Brooke Benner, Bhuvaneswari Ramaswamy, Maryam Lustberg, Rachel M. Layman, Erin Macrae, Mahmoud Kassem, Nicole Williams, Sagar Sardesai, Jeffrey VanDeusen…

    Citation: BMC Cancer 2020 20:445

    Content type: Research article

    Published on:

  26. Human papillomavirus (HPV) testing is more sensitive than cytology for detecting cervical cancer and its precursors. This study aimed to analyze the prevalence of high-risk HPV genotypes and evaluate the role ...

    Authors: Jing Zhang, Deyu Zhang, Zhuo Yang, Xiaobin Wang and Danbo Wang

    Citation: BMC Cancer 2020 20:443

    Content type: Research article

    Published on:

  27. The present study aims to evaluate long-term side-effects and outcomes and confirm prognostic factors after stereotactic body radiotherapy (SBRT) of pulmonary lesions. This is the first work that combines the ...

    Authors: Kerstin A. Kessel, Rebekka C. E. Grosser, Kim Melanie Kraus, Hans Hoffmann, Markus Oechsner and Stephanie E. Combs

    Citation: BMC Cancer 2020 20:442

    Content type: Research article

    Published on:

  28. For cervical cancer patients whose tumors display a combination of intermediate risk factors, postoperative radiation with or without adjuvant chemotherapy is suggested for them. However, who should be adminis...

    Authors: Hong-tao Guo, Xue-han Bi, Ting Lei, Xiao Lv, Guang Yao, Yao Chen and Chang Liu

    Citation: BMC Cancer 2020 20:441

    Content type: Research article

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  29. After neoadjuvant chemotherapy of breast cancer pathologic complete response (pCR) indicates a favorable prognosis. Among non-selected patients, pCR is, however, achieved in only 10–30%. Early evaluation of tu...

    Authors: Bernhard Tribukait

    Citation: BMC Cancer 2020 20:440

    Content type: Research article

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  30. Systemic inflammation and cachexia are associated with adverse clinical outcomes in diffuse large B-cell lymphoma (DLBCL). The Geriatric Nutritional Risk Index (GNRI) is one of the main parameters used to asse...

    Authors: Se-Il Go, Hoon-Gu Kim, Myoung Hee Kang, Sungwoo Park and Gyeong-Won Lee

    Citation: BMC Cancer 2020 20:439

    Content type: Research article

    Published on:

  31. Evidence suggests that physical activity (PA) is beneficial for reducing fatigue in colorectal cancer (CRC) survivors. However, little is known regarding long-term effects of PA on fatigue and whether pre-diag...

    Authors: Ruth Elisa Eyl, Melissa S. Y. Thong, Prudence R. Carr, Lina Jansen, Lena Koch-Gallenkamp, Michael Hoffmeister, Jenny Chang-Claude, Hermann Brenner and Volker Arndt

    Citation: BMC Cancer 2020 20:438

    Content type: Research article

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  32. Prostate cancer (PC) can display very heterogeneous phenotypes ranging from indolent asymptomatic to aggressive lethal forms. Understanding how these PC subtypes vary in their striving for energy and anabolic ...

    Authors: Ilona Dudka, Elin Thysell, Kristina Lundquist, Henrik Antti, Diego Iglesias-Gato, Amilcar Flores-Morales, Anders Bergh, Pernilla Wikström and Gerhard Gröbner

    Citation: BMC Cancer 2020 20:437

    Content type: Research article

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  33. Dihydropyrimidine dehydrogenase (DPD) status is an indicator of a marked risk for toxicity following fluoropyrimidine (FP)-based chemotherapy. This notion is well-established for low DPD status but little is k...

    Authors: Emmanuel Chamorey, Eric Francois, Marie-Christine Etienne, Jean-Marc Ferrero, Frederic Peyrade, Emmanuel Barranger, Alexandre Bozec, Rémy Largillier, Ophelie Cassuto, Julien Viotti, Renaud Schiappa and Gérard Milano

    Citation: BMC Cancer 2020 20:436

    Content type: Research article

    Published on:

  34. Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various e...

    Authors: Paulina Gil-Kulik, Ewa Dudzińska, Elżbieta Radzikowska-Büchner, Joanna Wawer, Mariusz Jojczuk, Adam Nogalski, Genowefa Anna Wawer, Marcin Feldo, Wojciech Kocki, Maria Cioch, Anna Bogucka-Kocka, Mansur Rahnama and Janusz Kocki

    Citation: BMC Cancer 2020 20:435

    Content type: Research article

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  35. Langerhans Cell Histiocytosis (LCH) is a rare disease puzzling both children and adults, however outcome of adult patients is unfavorable. This prospective interventional trial aims to test the efficacy and sa...

    Authors: Xiao Han, Mingqi Ouyang, Minghui Duan, Wei Zhang, Tienan Zhu, Jian Li, Shujie Wang and Daobin Zhou

    Citation: BMC Cancer 2020 20:433

    Content type: Research article

    Published on:

  36. The prevalence and correlates of job and insurance problems were examined among a cohort of young U.S. breast cancer survivors during the first 18-months following diagnosis.

    Authors: Michelle J. Naughton, Chloe M. Beverly Hery, Sarah A. Janse, Elizabeth Z. Naftalis, Electra D. Paskett and Kimberly J. Van Zee

    Citation: BMC Cancer 2020 20:432

    Content type: Research article

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  37. Identification of patient-related factors associated with Health-Related Quality of Life (HRQoL) and Quality of Life (QoL) at the start of treatment may identify patients who are prone to a decrease in HRQoL a...

    Authors: Mark de Mol, Sabine Visser, Joachim Aerts, Paul Lodder, Nico van Walree, Huub Belderbos and Brenda den Oudsten

    Citation: BMC Cancer 2020 20:431

    Content type: Research article

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  38. The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior.

    Authors: Toshiaki Iwase, Kenichi Harano, Hiroko Masuda, Kumiko Kida, Kenneth R. Hess, Ying Wang, Luc Dirix, Steven J. Van Laere, Anthony Lucci, Savitri Krishnamurthy, Wendy A. Woodward, Rachel M. Layman, François Bertucci and Naoto T. Ueno

    Citation: BMC Cancer 2020 20:430

    Content type: Research article

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  39. Adenosquamous carcinoma (ASC) is an uncommon histological subtype of lung cancer. The purpose of this study was to assess the cumulative incidences of lung cancer-specific mortality (LC-SM) and other cause-spe...

    Authors: Xiao Wu, Wenfeng Yu, R. H. Petersen, Hongxu Sheng, Yiqing Wang, Wang Lv and Jian Hu

    Citation: BMC Cancer 2020 20:429

    Content type: Research article

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  40. α-tocopherol (AT) and γ-tocotrienol (GT3) are vitamin E isoforms considered to have potential chemopreventive properties. AT has been widely studied in vitro and in clinical trials with mixed results. The late...

    Authors: Christine Moore, Victoria E. Palau, Rashid Mahboob, Janet Lightner, William Stone and Koyamangalath Krishnan

    Citation: BMC Cancer 2020 20:428

    Content type: Research article

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  41. PPFIA1 is an important regulator of cell migration and invasion, regulating focal adhesion signalling and disassembly. PPFIA1 is frequently amplified in breast cancer, and recent functional studies indicate th...

    Authors: Lutfi H. Alfarsi, Rokaya El Ansari, Madeleine L. Craze, Brendah K. Masisi, Ian O. Ellis, Emad A. Rakha and Andrew R. Green

    Citation: BMC Cancer 2020 20:425

    Content type: Research article

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  42. The CSC (cancer stem cell) markers often indicate poor prognosis and more cell invasion or migration of cancer patients. Podoplanin was assumed as a candidate CSC marker and predict poor prognosis among squamo...

    Authors: Liya Hu, Peng Zhang, Qi Mei, Wei Sun, Lei Zhou and Tiejun Yin

    Citation: BMC Cancer 2020 20:424

    Content type: Research article

    Published on:

  43. We aimed to assess whether disease-free survival (DFS) could serve as a reliable surrogate endpoint for overall survival (OS) in adjuvant trials of pancreatic cancer.

    Authors: Run-Cong Nie, Xue-Bin Zou, Shu-Qiang Yuan, Ying-Bo Chen, Shi Chen, Yong-Ming Chen, Guo-Ming Chen, Xiao-Jiang Chen, Tian-Qi Luo, Shu-Man Li, Jin-Ling Duan, Yun Wang and Yuan-Fang Li

    Citation: BMC Cancer 2020 20:421

    Content type: Research article

    Published on:

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