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  1. Adrenocortical carcinoma (ACC) is a rare malignant endocrine tumour. Due to a high tumour recurrence rate, the post-operative overall survival (OS) and disease-free survival (DFS) of ACCs is limited. Our resea...

    Authors: Jiayu Liang, Zhihong Liu, Xin Wei, Liang Zhou, Yongquan Tang, Chuan Zhou, Kan Wu, Fuxun Zhang, Fan Zhang, Yiping Lu and Yuchun Zhu

    Citation: BMC Cancer 2019 19:1165

    Content type: Research article

    Published on:

  2. Patients with metastatic spinal cord compression (MSCC) and favorable survival prognoses can benefit from radiation doses greater than 30Gy in 10 fractions in terms of improved local progression-free survival ...

    Authors: Dirk Rades, Olfred Hansen, Lars Henrik Jensen, Liesa Dziggel, Christian Staackmann, Claudia Doemer, Jon Cacicedo, Antonio J. Conde-Moreno, Barbara Segedin, Raquel Ciervide-Jurio, Carmen Rubio-Rodriguez, Luis A. Perez-Romasanta, Ana Alvarez-Gracia, Kristopher Dennis, Carlos Ferrer-Albiach, Arturo Navarro-Martin…

    Citation: BMC Cancer 2019 19:1163

    Content type: Study protocol

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  3. To compare the efficacy and safety between conventional transarterial chemoembolization (cTACE) and drug-eluting beads TACE (DEB-TACE) in patients with infiltrative hepatocellular carcinoma (iHCC).

    Authors: Zi-shu Zhang, Hui-zhou Li, Cong Ma and Yu-dong Xiao

    Citation: BMC Cancer 2019 19:1162

    Content type: Research article

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  4. Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is confirmed to participate in several tumor cell biological processes. However, the biological significance of SDC-1 in colorectal carcinoma is not...

    Authors: Shaojun Wang, Xiaofei Zhang, Guimei Wang, Bin Cao, Hong Yang, Lipeng Jin, Mingjuan Cui and Yongjun Mao

    Citation: BMC Cancer 2019 19:1160

    Content type: Research article

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  5. Breast cancer is one of the most commonly diagnosed cancers in women, with high morbidity and mortality. Tumor metastasis is implicated in most breast cancer deaths; thus, inhibiting metastasis may provide a t...

    Authors: Liyi Huang, Haidan Lin, Qing Chen, Lehua Yu and Dingqun Bai

    Citation: BMC Cancer 2019 19:1159

    Content type: Research article

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  6. Camptothecin (CPT) and its derivatives are currently used as second- or third-line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert nuclear enzyme DNA topoisomerase I (TO...

    Authors: Cinzia Tesauro, Anne Katrine Simonsen, Marie Bech Andersen, Kamilla Wandsoe Petersen, Emil Laust Kristoffersen, Line Algreen, Noriko Yokoyama Hansen, Anne Bech Andersen, Ann Katrine Jakobsen, Magnus Stougaard, Pavel Gromov, Birgitta R. Knudsen and Irina Gromova

    Citation: BMC Cancer 2019 19:1158

    Content type: Research article

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  7. Personalized therapy for bone metastases should consider the patients’ remaining lifespan. Estimation of survival can be facilitated with scoring tools. A new tool was developed, specifically designed to estim...

    Authors: Dirk Rades, Rapha Haus, Steven E. Schild and Stefan Janssen

    Citation: BMC Cancer 2019 19:1156

    Content type: Research article

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  8. Post-surgical staging is the mainstay of prognostic stratification for colorectal cancer (CRC). Here, we compare TNM staging to consensus molecular subtyping (CMS) and assess the value of subtyping in addition...

    Authors: Rachel V. Purcell, Sebastian Schmeier, Yee Chen Lau, John F. Pearson and Francis A. Frizelle

    Citation: BMC Cancer 2019 19:1155

    Content type: Research article

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  9. Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumor. Although lymph node metastasis has been reported, it is still considered benign. No malignant transformation has been reported. This is the first...

    Authors: Xiao Teng and Xiaodong Teng

    Citation: BMC Cancer 2019 19:1154

    Content type: Case report

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  10. Half of cancer cases occur in patients aged 70 and above. Majority of older patients are eligible for chemotherapy but evidence for treating this population is sparse and severe toxicities affect more than hal...

    Authors: Zara Steinmeyer, Stéphane Gérard, Thomas Filleron, Stéphanie Lozano, Delphine Brechemier, Gabor Abellan Van Kan, Loic Mourey, Laurence Cristol-Dalstein, Laure De Decker, Yves Rolland and Laurent Balardy

    Citation: BMC Cancer 2019 19:1153

    Content type: Study protocol

    Published on:

  11. Conventional cystoscopy can detect advanced stages of bladder cancer; however, it has limitations to detect bladder cancer at the early stages. Fluorocoxib A, a rhodamine-conjugated analog of indomethacin, is ...

    Authors: Jennifer Bourn, Kusum Rathore, Robert Donnell, Wesley White, Md. Jashim Uddin, Lawrence Marnett and Maria Cekanova

    Citation: BMC Cancer 2019 19:1152

    Content type: Research article

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  12. Chemotherapy-induced peripheral neuropathy (CIPN) is common among cancer patients treated with neurotoxic chemotherapy agents. Better knowledge on symptom clusters of CIPN may help improve symptom management i...

    Authors: Mian Wang, Hui Lin Cheng, Violeta Lopez, Raghav Sundar, Janelle Yorke and Alex Molassiotis

    Citation: BMC Cancer 2019 19:1151

    Content type: Research article

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  13. Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. Previously, only small studies investigated clinical and imaging features of MS. The purpo...

    Authors: Hans-Jonas Meyer, Wolfram Pönisch, Stefan Andreas Schmidt, Susanne Wienbeck, Friederike Braulke, Dominik Schramm and Alexey Surov

    Citation: BMC Cancer 2019 19:1150

    Content type: Research article

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  14. Neurolymphomatosis (NL) is a direct process of invasion of peripheral nerves by lymphoma. It occurs in roughly 5% of patients with lymphoma and represents a particularly difficult diagnostic dilemma when it is...

    Authors: Pierre R. Bourque, Marcos Loreto Sampaio, Jodi Warman-Chardon, Sam Samaan and Carlos Torres

    Citation: BMC Cancer 2019 19:1149

    Content type: Case report

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  15. The association between herpes zoster and the risk of lymphoid neoplasms in Asian populations has not yet been established. We performed a longitudinal follow-up study using a nationwide cohort to assess the r...

    Authors: Hyo Geun Choi, James L. Zehnder, Young Kyung Lee, Hyun Lim and Miyoung Kim

    Citation: BMC Cancer 2019 19:1148

    Content type: Research article

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  16. The advent of the immunomodulatory imide drugs (IMiDs) lenalidomide and thalidomide for the treatment of patients with plasma cell myeloma (PCM), has contributed to more than a doubling of the overall survival...

    Authors: Ryan B. Sinit, Dick G. Hwang, Prakash Vishnu, Jess F. Peterson and David M. Aboulafia

    Citation: BMC Cancer 2019 19:1147

    Content type: Case report

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  17. To evaluate the clinicopathological and prognostic significance of the percentage change between maximum standardized uptake value (SUVmax) at 60 min (SUVmax1) and SUVmax at 120 min (SUVmax2) (ΔSUVmax%) using dua...

    Authors: Yoji YAMAGISHI, Tomomi KOIWAI, Tamio YAMASAKI, Takahiro EINAMA, Makiko FUKUMURA, Miyuki HIRATSUKA, Takako KONO, Katsumi HAYASHI, Jiro ISHIDA, Hideki UENO and Hitoshi TSUDA

    Citation: BMC Cancer 2019 19:1146

    Content type: Research article

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  18. Genetic testing for BRCA1/2 genes is widely used as a strategy to reduce incidence and morbidity of hereditary breast and ovarian cancer (HBOC). The purpose of this study is to analyse the demographic and molecul...

    Authors: Ainara Ruiz de Sabando, Edurne Urrutia Lafuente, Fermín García-Amigot, Angel Alonso Sánchez, Lourdes Morales Garofalo, Sira Moreno, Eva Ardanaz and Maria A. Ramos-Arroyo

    Citation: BMC Cancer 2019 19:1145

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:1227

  19. The relationship between lung dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) associated with induction concurrent chemoradiotherapy (CCRT) followed by surgery in patients with non-small ...

    Authors: Kuniaki Katsui, Takeshi Ogata, Kenta Watanabe, Norihisa Katayama, Junichi Soh, Masahiro Kuroda, Katsuyuki Kiura, Yoshinobu Maeda, Shinichi Toyooka and Susumu Kanazawa

    Citation: BMC Cancer 2019 19:1144

    Content type: Research article

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  20. The aim of this study was to analyze biopsychosocial factors affecting how patients cope with cancer and adjuvant treatment and to appraise psychological distress, coping, perceived social support, quality of ...

    Authors: Teresa García-García, Alberto Carmona-Bayonas, Paula Jimenez-Fonseca, Carlos Jara, Carmen Beato, Beatriz Castelo, Montserrat Mangas, Eva Martínez de Castro, Avinash Ramchandani, David Gomez and Caterina Calderón

    Citation: BMC Cancer 2019 19:1143

    Content type: Research article

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  21. Chronic stress is well known to promote tumor progression, however, little is known whether chronic stress-mediated regulation of osteoblasts contributes to the migration and invasion of metastatic cancer cells.

    Authors: Zhibin Huang, Guihuan Li, Zhishuai Zhang, Ruonan Gu, Wenyang Wang, Xiaoju Lai, Zhong-Kai Cui, Fangyin Zeng, Shiyuan Xu and Fan Deng

    Citation: BMC Cancer 2019 19:1142

    Content type: Research article

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  22. The significance of very early chimerism assessment before day + 28, which is considered the moment of engraftment, is still unclear. In this retrospective study, we evaluated the clinical impact of very early...

    Authors: Monika Lejman, Agnieszka Zaucha-Prażmo, Joanna Zawitkowska, Aleksandra Mroczkowska, Dominik Grabowski, Jerzy R. Kowalczyk and Katarzyna Drabko

    Citation: BMC Cancer 2019 19:1141

    Content type: Research article

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  23. Recent studies have found that inflammatory response is involved in the pathogenesis of ovarian cancer. Advanced ovarian cancer is often presented with ascites that is rich in cytokines, inflammatory factors o...

    Authors: Jun Shi, Rongfen Huo, Ningli Li, Haichuan Li, Tianhang Zhai, Huidan Li, Baihua Shen, Jing Ye, Ruojin Fu and Wen Di

    Citation: BMC Cancer 2019 19:1140

    Content type: Research article

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  24. Thyroid nodules are frequently detected by cervical ultrasound examinations. In follow-up studies, malignant as well as benign nodules may exhibit an increase in size.

    Authors: Michael Cordes, Theresa Ida Götz, Karen Horstrup, Torsten Kuwert and Christian Schmidkonz

    Citation: BMC Cancer 2019 19:1139

    Content type: Research article

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  25. Many cancers are preventable through lifestyle modification; however, few adults engage in behaviors that are in line with cancer prevention guidelines. This may be partly due to the mixed messages on effectiv...

    Authors: Sarah E. Neil-Sztramko, Emily Belita, Anthony J. Levinson, Jennifer Boyko and Maureen Dobbins

    Citation: BMC Cancer 2019 19:1138

    Content type: Research article

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  26. Nuclear factor erythroid 2–related factor 2 (Nrf2) is involved in cell proliferation by promotion of metabolic activity. It is also the major regulator of antioxidants and has a pivotal role in tumor cell prol...

    Authors: Yoshiyuki Yamaguchi, Takao Kamai, Satoru Higashi, Satoshi Murakami, Kyoko Arai, Hiromichi Shirataki and Ken-Ichiro Yoshida

    Citation: BMC Cancer 2019 19:1137

    Content type: Research article

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  27. Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is associated with poor surgical outcomes. This study aims to construct a preoperative model to predict individual risk of po...

    Authors: Abdulahad Abdulrab Mohammed Al-Ameri, Xuyong Wei, Lidan Lin, Zhou Shao, Haijun Guo, Haiyang Xie, Lin Zhou, Shusen Zheng and Xiao Xu

    Citation: BMC Cancer 2019 19:1136

    Content type: Research article

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  28. Post-transplant lymphoproliferative disorders (PTLDs) represent a spectrum of heterogenetic lymphoid proliferations. PTLD is a serious complication that affects the long-term survival of kidney transplant pati...

    Authors: Jian-Chao Zhang, Hui-Xia Lan, Hui-Juan Zhao, Yang-Yang Lei, Li Ma, Xiao-Yan Xie, Ming-de Lu and Wei Wang

    Citation: BMC Cancer 2019 19:1135

    Content type: Case report

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  29. Vasculogenic mimicry (VM) a microvascular system consisting of non-endothelial cells that is newly formed by aggressive tumors, has been proposed as an important therapeutic target in malignant melanoma (MM). ...

    Authors: Zhenhua Zhang, Saber Imani, Marzieh Dehghan Shasaltaneh, Hossein Hosseinifard, Linglin Zou, Yu Fan and Qinglian Wen

    Citation: BMC Cancer 2019 19:1134

    Content type: Research article

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  30. Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of the urinary tract and requires life-long invasive surveillance to detect disease recurrence. Currently, there are no effective oral the...

    Authors: Remco J. Molenaar, Jons W. van Hattum, Iris S. Brummelhuis, Jorg R. Oddens, C. Dilara Savci-Heijink, Egbert R. Boevé, Saskia A. van der Meer, J. Fred Witjes, Michael N. Pollak, Theo M. de Reijke and Johanna W. Wilmink

    Citation: BMC Cancer 2019 19:1133

    Content type: Study protocol

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  31. Operable breast cancer patients may experience late recurrences because of reactivation of dormant tumor cells within the bone marrow (BM). Identification of patients who would benefit from extended therapy is...

    Authors: Kjersti Tjensvoll, Oddmund Nordgård, Maren Skjæveland, Satu Oltedal, Emiel A. M. Janssen and Bjørnar Gilje

    Citation: BMC Cancer 2019 19:1131

    Content type: Research article

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  32. Identification of key regulator/s in ovarian cancer (OC) network is important for potential drug target and prevention from this cancer. This study proposes a method to identify the key regulators of this netw...

    Authors: Md. Zubbair Malik, Keilash Chirom, Shahnawaz Ali, Romana Ishrat, Pallavi Somvanshi and R. K. Brojen Singh

    Citation: BMC Cancer 2019 19:1129

    Content type: Research article

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  33. Hepatocellular carcinoma (HCC) is the sixth-most common malignancy worldwide. Multiple previous studies have assessed the relationship between TM6SF2 gene polymorphism and the risk of developing HCC, with disc...

    Authors: Shan Tang, Jing Zhang, Ting-Ting Mei, Hai-Qing Guo, Xin-Huan Wei, Wen-Yan Zhang, Ya-Li Liu, Shan Liang, Zuo-Peng Fan, Li-Xia Ma, Wei Lin, Yi-Rong Liu, Li-Xia Qiu and Hai-Bin Yu

    Citation: BMC Cancer 2019 19:1128

    Content type: Research article

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  34. The platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) reflect the systematic inflammatory response, with some evidence revealing that they are ass...

    Authors: Hua-Long Zheng, Jun Lu, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Ping Li, Chao-Hui Zheng and Chang-Ming Huang

    Citation: BMC Cancer 2019 19:1127

    Content type: Research article

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  35. TAE-gene therapy for hepatoma, incorporating the tumor-targeted therapeutic efficacy of trans-arterial embolization, hydroxyapatite nanoparticles (nHAP) and anti-cancer wild-type p53 gene (wt-p53), was present...

    Authors: Gaopeng Li, Wenqin Kang, Mingliang Jin, Lidong Zhang, Jian Zheng, Kai Jia, Jinfeng Ma, Ting Liu, Xueyi Dang, Zhifeng Yan, Zefeng Gao and Jun Xu

    Citation: BMC Cancer 2019 19:1126

    Content type: Research article

    Published on:

  36. Chemotherapy can improve the survival of patients with advanced gastric cancer. However, whether triplet chemotherapy can further improve the survival of patients with advanced gastric cancer compared with dou...

    Authors: Xinjian Guo, Fuxing Zhao, Xinfu Ma, Guoshuang Shen, Dengfeng Ren, Fangchao Zheng, Feng Du, Ziyi Wang, Raees Ahmad, Xinyue Yuan, Junhui Zhao and Jiuda Zhao

    Citation: BMC Cancer 2019 19:1125

    Content type: Research article

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  37. Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1+/MAGE-A4), which fail to differentiate to pre-spermatogonia (POU...

    Authors: Maria E. Camacho-Moll, Joni Macdonald, L. H. J. Looijenga, Michael P. Rimmer, Roland Donat, John A. Marwick, C. J. Shukla, Neil Carragher, Anne Jørgensen and Rod T. Mitchell

    Citation: BMC Cancer 2019 19:1124

    Content type: Research article

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  38. The rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (HIF1A) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitivel...

    Authors: Li-Fang Wu, Gui-Ping Xu, Qing Zhao, Li-Jing Zhou, Ding Wang and Wei-Xian Chen

    Citation: BMC Cancer 2019 19:1123

    Content type: Research article

    Published on:

  39. To assess the efficacy of Nimotuzumab in combination with first-line chemoradiotherapy treatment in Chinese patients with primary III-IVb stage nasopharyngeal carcinoma.

    Authors: Wang Zhi-Qiang, Mei Qi, Li Ji-Bin, You Rui, Liu You-Ping, Sun Rui, Hu Guang-Yuan, Chen Ming-Yuan and Hua Yi-Jun

    Citation: BMC Cancer 2019 19:1122

    Content type: Research article

    Published on:

  40. High grade serous ovarian carcinoma (HGSOC) is the most common subtype of epithelial ovarian cancers (EOC) with poor prognosis. In most cases EOC is widely disseminated at the time of diagnosis. Despite the op...

    Authors: H. Sallinen, S. Janhonen, P. Pölönen, H. Niskanen, O. H. Liu, A. Kivelä, J. M. Hartikainen, M. Anttila, M. Heinäniemi, S. Ylä-Herttuala and M. U. Kaikkonen

    Citation: BMC Cancer 2019 19:1121

    Content type: Research article

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  41. Kidney transplantation (KT) correlates with an increased risk of developing several malignancies; however, the risk of colorectal cancer (CRC) after KT remains debatable and has been marginally explored. Hence...

    Authors: Han-En Wang, Yu-Chan Liao, Je-Ming Hu, Wen-Chih Wu, Wan-Yun Chou, Yong-Chen Chen, Yu-Ching Chou, Chi-Feng Hung, Yu-Feng Tian, San-Lin You and Chien-An Sun

    Citation: BMC Cancer 2019 19:1120

    Content type: Research article

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  42. Intracranial metastasis of Gastrointestinal Stromal Tumors (GISTs) is rare but presents unique treatment challenges. We present a case of intracranial metastasis of GIST with a systematic review of the literat...

    Authors: Marc Prablek, Visish M. Srinivasan, Aditya Srivatsan, Stephanie Holdener, Mazen Oneissi, Kent A. Heck, Ali Jalali, Jacob Mandel, Ashwin Viswanathan and Akash J. Patel

    Citation: BMC Cancer 2019 19:1119

    Content type: Case report

    Published on:

  43. The CAO/ARO/AIO-94 demonstrated that neoadjuvant chemoradiotherapy (CRT) could decrease the rate of local recurrence rather than distal metastases in advanced rectal cancer. Adjuvant chemotherapy (ACT) can eli...

    Authors: Qingguo Li, Dakui Luo, Ji Zhu, Lifeng Yang, Qi Liu, Yanlei Ma, Lei Liang, Sanjun Cai, Zhen Zhang and Xinxiang Li

    Citation: BMC Cancer 2019 19:1117

    Content type: Study protocol

    Published on:

  44. Glioma is a common malignant tumours in the central nervous system (CNS), that exhibits high morbidity, a low cure rate, and a high recurrence rate. Currently, immune cells are increasingly known to play roles...

    Authors: Qiu-Yue Zhong, Er-Xi Fan, Guang-Yong Feng, Qi-Ying Chen, Xiao-Xia Gou, Guo-Jun Yue and Gui-hai Zhang

    Citation: BMC Cancer 2019 19:1116

    Content type: Database

    Published on:

  45. The aim was to investigate the prognostic value of MR apparent diffusion coefficients (ADC) using histogram analysis (HA) in predicting disease-free survival (DFS) of cervical cancer after chemo-radiation ther...

    Authors: Bo Zhao, Kun Cao, Xiao-Ting Li, Hai-Tao Zhu and Ying-Shi Sun

    Citation: BMC Cancer 2019 19:1115

    Content type: Research article

    Published on:

  46. We investigated the association of LHR expression in epithelial ovarian cancer (OC) with clinical and pathologic characteristics of patients. LHR expression was examined immunohistochemically using tissue micr...

    Authors: Shigang Xiong, Paulette Mhawech-Fauceglia, Denice Tsao-Wei, Lynda Roman, Rajesh K. Gaur, Alan L. Epstein and Jacek Pinski

    Citation: BMC Cancer 2019 19:1114

    Content type: Research article

    Published on:

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