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  1. Content type: Research article

    Analysis of melanomas for actionable mutations has become the standard of care. Recently, a classification scheme has been proposed that categorizes BRAF mutations based on their mechanisms for activation of the ...

    Authors: Parvez M. Lokhandwala, Li-Hui Tseng, Erika Rodriguez, Gang Zheng, Aparna Pallavajjalla, Christopher D. Gocke, James R. Eshleman and Ming-Tseh Lin

    Citation: BMC Cancer 2019 19:665

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  2. Content type: Research article

    A standard therapy for locally advanced rectal cancer (LARC) includes fluoropyrimidine (FP)-based neoadjuvant chemoradiation (nCRT). Previous studies have inconsistently demonstrated that baseline neutrophil- ...

    Authors: Shaan Dudani, Horia Marginean, Patricia A. Tang, Jose G. Monzon, Soundouss Raissouni, Timothy R. Asmis, Rachel A. Goodwin, Joanna Gotfrit, Winson Y. Cheung and Michael M. Vickers

    Citation: BMC Cancer 2019 19:664

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  3. Content type: Study protocol

    An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of lymph node metastases depends on tumor characteristics such as tumor location, histology, inv...

    Authors: Eliza R. C. Hagens, Mark I. van Berge Henegouwen, Johanna W. van Sandick, Miguel A. Cuesta, Donald L. van der Peet, Joos Heisterkamp, Grard A. P. Nieuwenhuijzen, Camiel Rosman, Joris J. G. Scheepers, Meindert N. Sosef, Richard van Hillegersberg, Sjoerd M. Lagarde, Magnus Nilsson, Jari Räsänen, Philippe Nafteux, Piet Pattyn…

    Citation: BMC Cancer 2019 19:662

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  4. Content type: Research article

    The physical activity (PA) level of patients undergoing major cancer surgery remains unclear. This pilot study aimed to: (i) Compare preoperative PA level between patients undergoing major cancer surgery and t...

    Authors: Daniel Steffens, Jane M. Young, Michael Solomon, Paula R. Beckenkamp, Cherry Koh, Kenneth Vuong, Matthew A. Brodie and Kim Delbaere

    Citation: BMC Cancer 2019 19:661

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  5. Content type: Study protocol

    Breast cancer is the most common cancer diagnosed in women worldwide. In developed countries, 80–90% of women will survive five years after diagnosis but the transition from hospital-based care to health self-...

    Authors: A. Singleton, S. R. Partridge, R. Raeside, M. Regimbal, K. K. Hyun, C. K. Chow, K. Sherman, E. Elder and J. Redfern

    Citation: BMC Cancer 2019 19:660

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  6. Content type: Research article

    In order to maximize later health, there are established components and guidelines for quality follow-up care of breast cancer survivors. However, adherence to quality follow-up in Canada may not be optimal, a...

    Authors: Mary L. McBride, Patti A. Groome, Kathleen Decker, Cynthia Kendell, Li Jiang, Marlo Whitehead, Dongdong Li and Eva Grunfeld

    Citation: BMC Cancer 2019 19:659

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  7. Content type: Research article

    Expression of Bcr-Abl in hematopoietic stem cells is sufficient to cause chronic myeloid leukemia (CML) and tyrosine kinase inhibitors (TKI) induce molecular remission in the majority of CML patients. However,...

    Authors: Oliver Herrmann, Maja Kim Kuepper, Marlena Bütow, Ivan G. Costa, Iris Appelmann, Fabian Beier, Tom Luedde, Till Braunschweig, Steffen Koschmieder, Tim H. Brümmendorf and Mirle Schemionek

    Citation: BMC Cancer 2019 19:658

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  8. Content type: Research article

    The use of nomograms for prognostication of individual cancer patients has been recommended in order to facilitate precision medicine. However, models for patients with soft tissue sarcomas (STSs) are limited ...

    Authors: Masaya Sekimizu, Koichi Ogura, Hideo Yasunaga, Hiroki Matsui, Sakae Tanaka, Katsunori Inagaki and Akira Kawai

    Citation: BMC Cancer 2019 19:657

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  9. Content type: Study protocol

    Despite an overwhelming body of evidence showing the benefits of physical activity (PA) and exercise for cancer survivors, few survivors meet the exercise oncology guidelines. Moreover, initiating, let alone m...

    Authors: Kirsten N. Adlard, David G. Jenkins, Chloe E. Salisbury, Kate A. Bolam, Sjaan R. Gomersall, Joanne F. Aitken, Suzanne K. Chambers, Jeff C. Dunn, Kerry S. Courneya and Tina L. Skinner

    Citation: BMC Cancer 2019 19:656

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  10. Content type: Study protocol

    Since 2011, a tailored, interdisciplinary head and neck rehabilitation (IHNR) program, covered by the basic healthcare insurance, is offered to advanced head and neck cancer (HNC) patients in the Netherlands C...

    Authors: Ann-Jean C. C. Beck, Ellen Passchier, Valesca P. Retèl, Martijn M. Stuiver, Lisette van der Molen, Willem M. C. Klop, Arash Navran, Wim H. van Harten and Michiel W. M. van den Brekel

    Citation: BMC Cancer 2019 19:655

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  11. Content type: Research article

    Yes-associated protein (YAP) plays a crucial role in tumour development and it is the main effector of the Hippo signalling pathway. However, the mechanism underlying YAP downregulation in laryngeal cancer is ...

    Authors: Xiaomin Tang, Yuxuan Sun, Ganglun Wan, Jiaqiang Sun, Jingwu Sun and Chunchen Pan

    Citation: BMC Cancer 2019 19:654

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  12. Content type: Research article

    Anthracycline-based chemotherapy is associated with reduced cardiorespiratory fitness in breast cancer patients. High intensity interval training (HIIT) induces greater benefits on cardiorespiratory fitness th...

    Authors: Kyuwan Lee, Irene Kang, Wendy J. Mack, Joanne Mortimer, Fred Sattler, George Salem and Christina M. Dieli-Conwright

    Citation: BMC Cancer 2019 19:653

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  13. Content type: Research article

    There is no standard first-line chemotherapy for advanced gastric cancer with severe peritoneal metastasis. Although fluoropyrimidine is often used, its efficacy is limited, and it remains unclear whether comb...

    Authors: Hiroyuki Arai, Satoru Iwasa, Narikazu Boku, Masahiro Kawahira, Hirofumi Yasui, Toshiki Masuishi, Kei Muro, Keiko Minashi, Shuichi Hironaka, Naoki Fukuda, Daisuke Takahari and Takako Eguchi Nakajima

    Citation: BMC Cancer 2019 19:652

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  14. Content type: Research article

    Aneuploidy of chromosome 8 in circulating tumor cells (CTCs) has been reported correlates with therapeutic efficacy and prognosis in patients with advanced gastric cancer. However, it is not clear whether it i...

    Authors: Yingjie Chen, Zhipeng Yang, Yingxue Wang, Juandong Wang and Chuanxin Wang

    Citation: BMC Cancer 2019 19:651

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  15. Content type: Research article

    DNA aneuploidy has attracted growing interest in clinical practice. Nevertheless, its prognostic value in gastric cancer patients remains controversial. This meta-analysis aims to explore the impact of DNA plo...

    Authors: Jing Xu, Ruolin Zhu, Lulu Fan, Shangqing Ge, Wei Wei, Xiaoqiu Li, Liangshan Da, Zhenya Jia, Zhiyan Zhao, Jie Ning, Jie Da, Wanren Peng, Kangsheng Gu and Guoping Sun

    Citation: BMC Cancer 2019 19:650

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  16. Content type: Research article

    Prognostication of patients with colorectal cancer (CRC) currently relies on tumor-node-metastasis (TNM) staging but clinical outcomes of patients of the same histoclinical stage are heterogeneous. It is there...

    Authors: Tung H. Ng, Kathy W. Y. Sham, Chuan M. Xie, Simon S. M. Ng, Ka F. To, Joanna H. M. Tong, Wing Y. Z. Liu, Lin Zhang, Matthew T. V. Chan, William K. K. Wu and Christopher H. K. Cheng

    Citation: BMC Cancer 2019 19:649

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  17. Content type: Study protocol

    Studies have consistently indicated that the majority of individuals meeting the US Prevention Services Task Force guidelines for genetic testing have not had genetic counseling or testing. Despite increased a...

    Authors: Nadine Rayes, Deborah J. Bowen, Tara Coffin, Denise Nebgen, Christine Peterson, Mark F. Munsell, Kathleen Gavin, Rebecca Lechner, Jamie Crase, Deborah Polinsky, Iris Romero, Stephanie V. Blank, Douglas A. Levine, Barbara M. Norquist, Elizabeth M. Swisher and Karen H. Lu

    Citation: BMC Cancer 2019 19:648

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  18. Content type: Research article

    Recently, long non-coding RNAs (lncRNAs) were considered as important gene expression regulators involving various biological processes. In this study, we explored the role of lncRNAs in the pathogenesis of ra...

    Authors: Ju-Mei Zhou, Rong Liang, Su-Yu Zhu, Hui Wang, Min Zou, Wei-Jing Zou and Shao-Lin Nie

    Citation: BMC Cancer 2019 19:647

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  19. Content type: Research article

    One challenge in caring for cancer patients with incurable disease is the adequate identification of those in need for specialized palliative care (SPC). The study’s aim was to validate an easy to use phenomen...

    Authors: Christoph Ostgathe, Kim N. Wendt, Maria Heckel, Sandra Kurkowski, Carsten Klein, Stefan W. Krause, Florian S. Fuchs, Christian M. Bayer and Stephanie Stiel

    Citation: BMC Cancer 2019 19:646

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  20. Content type: Research article

    Ovarian cancer (OC) is the second most frequent gynecological cancer and is associated with a poor prognosis because OC progression is often asymptoma-tic and is detected at a late stage. There remains an urge...

    Authors: Bin Liu, Xiaojie Huang, Yifang Li, Weiguo Liao, Mingyi Li, Yi Liu, Rongrong He, Du Feng, Runzhi Zhu and Hiroshi Kurihara

    Citation: BMC Cancer 2019 19:645

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  21. Content type: Research article

    Smoking cessation is a key step towards improving cancer care and outcomes. However, smoking cessation interventions are underprovided in oncology settings. Within Jordan’s only comprehensive oncology center, ...

    Authors: F. I. Hawari, N. A. Obeidat, D. Rimawi and K. Jamal

    Citation: BMC Cancer 2019 19:580

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  22. Content type: Research article

    The prognosis of colorectal cancer (CRC) patients can be influenced by genetic mutations and nutritional status. The relationship between these variables is unclear. The objective of the study was to verify th...

    Authors: Mariana Abe Vicente Cavagnari, Tiago Donizetti Silva, Marco Antonio Haddad Pereira, Luísa Jacques Sauer, David Shigueoka, Sarhan Sydney Saad, Katia Barão, Carla Caroline Dias Ribeiro and Nora Manoukian Forones

    Citation: BMC Cancer 2019 19:644

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  23. Content type: Research article

    Investigations of colorectal carcinogenesis have mainly focused on examining neoplastic tissue. With our aim of identifying potentially cancer-predisposing molecular compositions, we chose a different approach...

    Authors: Christian Hunnicke Petersen, Badar Mahmood, Christoffer Badsted, Tina Dahlby, Hanne Borger Rasmussen, Mark Berner Hansen and Niels Bindslev

    Citation: BMC Cancer 2019 19:643

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  24. Content type: Research article

    Altered expression of microRNAs (miRNAs) is known to contribute to cancer progression. miR-23b and miR-27b, encoded within the same miRNA cluster, are reported to have both tumor suppressive and oncogenic acti...

    Authors: Bethany N. Hannafon, Angela Cai, Cameron L. Calloway, Yi-Fan Xu, Roy Zhang, Kar-Ming Fung and Wei-Qun Ding

    Citation: BMC Cancer 2019 19:642

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  25. Content type: Research article

    Delivering widespread BRCA testing to patients with ovarian cancer has been suggested by several scientists, recommended by professional societies and solicited by patients organizations. However, based on the...

    Authors: A. V. Paradiso, M. Digennaro, M. Patruno, S. De Summa, S. Tommasi and I. Berindan-Neagoe

    Citation: BMC Cancer 2019 19:641

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  26. Content type: Study protocol

    In the management of patients with RAS wild-type metastatic colorectal cancer (mCRC), anti-epidermal growth factor receptor (EGFR) therapies have demonstrated a clinical benefit, with longer survival. However, th...

    Authors: Shang-Hung Chen, Hsiang-Lin Tsai, Jeng-Kai Jiang, Yung-Chuan Sung, Ching-Wen Huang, Yu-Min Yeh, Li-Tzong Chen and Jaw-Yuan Wang

    Citation: BMC Cancer 2019 19:640

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  27. Content type: Research article

    To evaluate the outcome of patients treated with stereotactic ablative body radiotherapy (SABR) with curative intent for stage I non-small cell lung cancer (NSCLC) with regard to local, regional and distant tu...

    Authors: Emilie Dubaere, Mathilde Goffaux, Marie Wanet, Benoit Bihin, Céline Gheldof, Anne-Sophie Demoulin, Antoine Bolly, Frederique Bustin, Fabrice Duplaquet, Paul-Emile Baugnee, Michel Gustin, Vincent Hers, Fabienne Maisin, Eric Marchand, Sebahat Ocak, Lionel Pirard…

    Citation: BMC Cancer 2019 19:639

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  28. Content type: Research article

    The optimal reconstructive method after diaphyseal malignant bone tumor resection remains controversial. This multicenter clinical study was designed to investigate the clinical value and complications of segm...

    Authors: Kai Zheng, Xiu-chun Yu, Yong-cheng Hu, Zeng-wu Shao, Ming Xu, Bai-chuan Wang and Feng Wang

    Citation: BMC Cancer 2019 19:638

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  29. Content type: Research article

    Puerto Rico has the highest incidence rate of thyroid cancer (TC) in the Americas and the third highest rate worldwide. The purpose of this study was to compare the burden of TC between the population of PR an...

    Authors: Guillermo Tortolero-Luna, Carlos R. Torres-Cintrón, Mariela Alvarado-Ortiz, Karen J. Ortiz-Ortiz, Diego E. Zavala-Zegarra and Edna Mora-Piñero

    Citation: BMC Cancer 2019 19:637

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  30. Content type: Research article

    Muscle-invasive bladder tumors are associated with a high risk of relapse and metastasis even after neoadjuvant chemotherapy and radical cystectomy. Therefore, further therapeutic options are needed and molecu...

    Authors: Lucía Trilla-Fuertes, Angelo Gámez-Pozo, Guillermo Prado-Vázquez, Andrea Zapater-Moros, Mariana Díaz-Almirón, Jorge M. Arevalillo, María Ferrer-Gómez, Hilario Navarro, Paloma Maín, Enrique Espinosa, Álvaro Pinto and Juan Ángel Fresno Vara

    Citation: BMC Cancer 2019 19:636

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  31. Content type: Research article

    Zinc-finger E-box binding homeobox 1 (ZEB-1) plays crucial roles in epithelial-to-mesenchymal transition during tumor carcinogenesis. Published studies have examined the potential value of ZEB-1 as a biomarker...

    Authors: Borong Chen, Baisheng Chen, Zhipeng Zhu, Weipeng Ye, Junjie Zeng, Gang Liu, Shengjie Wang, Jin Gao, Guoxing Xu and Zhengjie Huang

    Citation: BMC Cancer 2019 19:635

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  32. Content type: Research article

    Metastasis is a leading cause of breast cancer mortality. The induction of epithelial-to-mesenchymal transition (EMT) and complex oncogenic signaling is a vital step in the evolution of highly metastatic and t...

    Authors: Jia-Hong Chen, Wen-Chien Huang, Oluwaseun Adebayo Bamodu, Peter Mu-Hsin Chang, Tsu-Yi Chao and Tse-Hung Huang

    Citation: BMC Cancer 2019 19:634

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  33. Content type: Research article

    The recent implementation of PET with prostate specific membrane antigen (PSMA)-specific radiotracers into the clinical practice has resulted in the significant improvement of accuracy in the detection of pros...

    Authors: Heike Endepols, Agnieszka Morgenroth, Boris D. Zlatopolskiy, Philipp Krapf, Johannes Zischler, Raphael Richarz, Sergio Muñoz Vásquez, Bernd Neumaier and Felix M. Mottaghy

    Citation: BMC Cancer 2019 19:633

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  34. Content type: Research article

    A key challenge in phase I trials is maintaining rapid escalation in order to avoid exposing too many patients to sub-therapeutic doses, while preserving safety by limiting the frequency of toxic events. Tradi...

    Authors: Bernard North, Hemant Mahendrakumar Kocher and Peter Sasieni

    Citation: BMC Cancer 2019 19:632

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  35. Content type: Research article

    Mammographic density is one of the strongest risk factors for breast cancer. In the general population, mammographic density can be modified by various exposures; whether this is true for women a strong family...

    Authors: Olivia Moran, Andrea Eisen, Rochelle Demsky, Kristina Blackmore, Julia A. Knight, Seema Panchal, Ophira Ginsburg, Kevin Zbuk, Martin Yaffe, Kelly A. Metcalfe, Steven A. Narod and Joanne Kotsopoulos

    Citation: BMC Cancer 2019 19:631

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  36. Content type: Research article

    Globally, the incidence and mortality rates of gastric cancer are high, and its poor prognosis is closely related to tumor recurrence and metastasis. Therefore, the molecular mechanisms associated with the mig...

    Authors: Yaoyue Qi, Jing Lv, Shihai Liu, Libin Sun, Yixuan Wang, Hui Li, Weiwei Qi and Wensheng Qiu

    Citation: BMC Cancer 2019 19:630

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  37. Content type: Research article

    This study aimed to evaluate the value of chitinase activity in prognosticating the occurrence of metastasis in and prognosis of patients with colorectal cancer (CRC).

    Authors: Zhangfa Song, Engeng Chen, Jun Qian, Jianbin Xu, Gaoyang Cao, Wei Zhou, Fei Wang, Min Chen, Dengyong Xu, Xiaowei Wang, Xiaotong Hu, Zhenyu Ju, Xuefeng Huang and Xiujun Cai

    Citation: BMC Cancer 2019 19:629

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  38. Content type: Research article

    A major barrier to effective treatment of glioblastoma (GBM) is the large intertumoral heterogeneity at the genetic and cellular level. In early phase clinical trials, patient heterogeneity in response to ther...

    Authors: Erlend Skaga, Evgeny Kulesskiy, Artem Fayzullin, Cecilie J. Sandberg, Swapnil Potdar, Aija Kyttälä, Iver A. Langmoen, Aki Laakso, Emília Gaál-Paavola, Markus Perola, Krister Wennerberg and Einar O. Vik-Mo

    Citation: BMC Cancer 2019 19:628

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  39. Content type: Research article

    Despite latest advances in prostate cancer (PCa) therapy, PCa remains the third-leading cause of cancer-related death in European men. Dysregulation of microRNAs (miRNAs), small non-coding RNA molecules with g...

    Authors: Mirjam Kiener, Lanpeng Chen, Markus Krebs, Joël Grosjean, Irena Klima, Charis Kalogirou, Hubertus Riedmiller, Burkhard Kneitz, George N. Thalmann, Ewa Snaar-Jagalska, Martin Spahn, Marianna Kruithof-de Julio and Eugenio Zoni

    Citation: BMC Cancer 2019 19:627

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  40. Content type: Research article

    Sentinel node biopsy (SNB) is the standard procedure for axillary staging in patients with clinically lymph node negative invasive breast cancer. Completion axillary lymph node dissection (c-ALND) may not be n...

    Authors: Shabaz Majid, Lisa Rydén and Jonas Manjer

    Citation: BMC Cancer 2019 19:626

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  41. Content type: Research article

    Chemotherapy may be a valuable treatment option as neoadjuvant treatment for locally advanced penile cancer according to some previous studies, but the rarity of the sample and the Lack of large-scale clinical...

    Authors: Jian Xu, Gang Li, Shi Miao Zhu, Qi Liang Cai, Zhun Wang, Xiong Yang, Hong Tan Zhang and Yuan Jie Niu

    Citation: BMC Cancer 2019 19:625

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  42. Content type: Research article

    Nasopharyngeal carcinoma (NPC) is a malignant disease with an enigmatic etiology. NPC associates with Epstein-Barr virus (EBV) and human papillomaviruses (HPVs), while immunological factors also play a role in...

    Authors: Miia Ruuskanen, Ilmo Leivo, Heikki Minn, Tero Vahlberg, Caj Haglund, Jaana Hagström and Heikki Irjala

    Citation: BMC Cancer 2019 19:624

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  43. Content type: Study protocol

    A cytotoxic chemotherapeutic regimen is not routinely recommended for frail elderly patients with unresectable colorectal cancer (CRC) because of susceptibility to treatment. Panitumumab is a monoclonal antibo...

    Authors: Tetsuji Terazawa, Takeshi Kato, Masahiro Goto, Daisuke Sakai, Yukinori Kurokawa, Toshio Shimokawa, Yoshihiro Matsubara and Taroh Satoh

    Citation: BMC Cancer 2019 19:623

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  44. Content type: Research article

    Noninvasive biomarkers are urgently needed for optimal management of nonalcoholic fatty liver disease (NAFLD) for the prevention of disease progression into nonalcoholic steatohepatitis (NASH) and hepatocellul...

    Authors: Naohiko Nakamura, Etsuro Hatano, Kohta Iguchi, Motohiko Sato, Hiroaki Kawaguchi, Iwao Ohtsu, Takaki Sakurai, Nobuhiro Aizawa, Hiroko Iijima, Shuhei Nishiguchi, Takuya Tomono, Yukihiro Okuda, Seidai Wada, Satoru Seo, Kojiro Taura, Shinji Uemoto…

    Citation: BMC Cancer 2019 19:621

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  45. Content type: Correction

    Following publication of the original article [1], the authors reported the following errors in the article.

    Authors: Edith A. Perez, Sanne Lysbet de Haas, Wolfgang Eiermann, Carlos H. Barrios, Masakazu Toi, Young-Hyuck Im, Pier Franco Conte, Miguel Martin, Tadeusz Pienkowski, Xavier B. Pivot, Howard A. Burris III, Sven Stanzel, Monika Patre and Paul Anthony Ellis

    Citation: BMC Cancer 2019 19:620

    Published on:

    The original article was published in BMC Cancer 2019 19:517

  46. Content type: Research article

    Ovarian cancer is the most common malignant tumor of the female reproductive tract. Chemoresistance is a major challenge for current ovarian cancer therapy. However, the mechanism underlying epithelial ovarian...

    Authors: Junli Deng, Xupeng Bai, Xiaojie Feng, Jie Ni, Julia Beretov, Peter Graham and Yong Li

    Citation: BMC Cancer 2019 19:618

    Published on:

  47. Content type: Research article

    Malignant pleural effusion (MPE) is a devastating sequela associated with cancer. Talc pleurodesis is a common treatment strategy for MPE but has been estimated to be unsuccessful in up to 20–50% of patients. ...

    Authors: Tim N. Beck, Alexander Y. Deneka, Louis Chai, Colin Kanach, Priya Johal, Nicolas J. Alvarez, Yanis Boumber, Erica A. Golemis and Glenn W. Laub

    Citation: BMC Cancer 2019 19:614

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