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  1. SOCS1 and SOCS3 genes are considered tumor suppressors in hepatocellular carcinoma (HCC) due to frequent epigenetic repression. Consistent with this notion, mice lacking SOCS1 or SOCS3 show increased susceptibili...

    Authors: Md Gulam Musawwir Khan, Amit Ghosh, Bhavesh Variya, Madanraj Appiya Santharam, Awais Ullah Ihsan, Sheela Ramanathan and Subburaj Ilangumaran

    Citation: BMC Cancer 2020 20:774

    Content type: Research article

    Published on:

  2. The AMP-activated protein kinase (AMPK) is an evolutionarily conserved regulator of cellular energy homeostasis. As a nexus for transducing metabolic signals, AMPK cooperates with other energy-sensing pathways...

    Authors: Wai Hoong Chang and Alvina G. Lai

    Citation: BMC Cancer 2020 20:773

    Content type: Research article

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  3. Autophagy is a programmed cell degradation mechanism that has been associated with several physiological and pathophysiological processes, including malignancy. Improper induction of autophagy has been propose...

    Authors: Xingxing Huo, Jian Qi, Kaiquan Huang, Su Bu, Wei Yao, Ying Chen and Jinfu Nie

    Citation: BMC Cancer 2020 20:771

    Content type: Research article

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  4. Leukotriene receptor antagonists (LTRAs) are broadly used for the management of allergic asthma and have recently been indicated to inhibit carcinogenesis and cancer cell growth. In colorectal cancer (CRC) che...

    Authors: Takuma Higurashi, Jun Arimoto, Keiichi Ashikari, Tomohiro Takatsu, Noboru Misawa, Tsutomu Yoshihara, Tetsuya Matsuura, Akiko Fuyuki, Hidenori Ohkubo and Atsushi Nakajima

    Citation: BMC Cancer 2020 20:770

    Content type: Study protocol

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  5. The impact and consequences of cancer on the patients and their family caregivers (FCs) are closely intertwined. Caregivers’ burdens can be increased due to the patients’ unmet needs and unresolved problems. A...

    Authors: Gek Phin Chua, Grace Su Yin Pang, Alethlea Chung Pheng Yee, Patricia Soek Hui Neo, Siqin Zhou, Cindy Lim, Yin Yee Wong, Debra Limin Qu, Fang Ting Pan and Grace Meijuan Yang

    Citation: BMC Cancer 2020 20:768

    Content type: Research article

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  6. To evaluate proton-density fat-fraction (PDFF) and intravoxel incoherent motion (IVIM) techniques, and human 25-hydroxyvitamin D3 (25OH-VitD3) levels, as potential biomarkers in patients with colorectal cancer...

    Authors: Qian Wang, Feng Ye, Peiqing Ma, Yiqun Che, Weilan Guo, Dong Yan and Xinming Zhao

    Citation: BMC Cancer 2020 20:767

    Content type: Research article

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  7. Sphingosine-1-phosphate receptor (S1PR1) is involved in vascular development, a key process in tumorigenesis. This study aimed to evaluate its roles in tumor development and prognosis.

    Authors: Limei Zhong, Linling Xie, Zhiyong Yang, Lijuan Li, Shaohua Song, Donglin Cao and Yufeng Liu

    Citation: BMC Cancer 2020 20:766

    Content type: Research article

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  8. In patients with differentiated thyroid cancer (DTC), tumor burden of persistent disease (PD) is a variable that could affect therapy efficiency. Our aim was to assess its correlation with the 2015 American Th...

    Authors: Renaud Ciappuccini, Natacha Heutte, Audrey Lasne-Cardon, Virginie Saguet-Rysanek, Camille Leroy, Véronique Le Hénaff, Dominique Vaur, Emmanuel Babin and Stéphane Bardet

    Citation: BMC Cancer 2020 20:765

    Content type: Research article

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  9. The likelihood of a tumor recurrence in patients with T3-4N0–1 non-small cell lung cancer following multimodality treatment remains substantial, mainly due distant metastases. As pathological complete response...

    Authors: Chris Dickhoff, Suresh Senan, Famke L. Schneiders, Joris Veltman, Sayed Hashemi, Johannes M. A. Daniels, Marieke Fransen, David J. Heineman, Teodora Radonic, Peter M. van de Ven, Imke H. Bartelink, Lilian J. Meijboom, Juan J. Garcia-Vallejo, Daniela E. Oprea-Lager, Tanja D. de Gruijl and Idris Bahce

    Citation: BMC Cancer 2020 20:764

    Content type: Study protocol

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  10. To evaluate the feasibility and effectiveness of artificial ascites to assist thermal ablation of liver cancer adjacent to the gastrointestinal tract in patients with previous abdominal surgery.

    Authors: Qiannan Huang, Jianguo Li, Qingjing Zeng, Lei Tan, Rongqin Zheng, Xuqi He and Kai Li

    Citation: BMC Cancer 2020 20:763

    Content type: Research article

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  11. Globally, colorectal cancer (CRC) is the third and second leading cancer in men and women respectively with 600,000 deaths per year. Traditionally, clinicians have relied solely on nodal disease involvement, a...

    Authors: Ali Riaz Baqar, Simon Wilkins, Wei Wang, Karen Oliva and Paul McMurrick

    Citation: BMC Cancer 2020 20:762

    Content type: Research article

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  12. This study aimed to evaluate the short- and long-term outcomes after laparoscopic resection for low rectal cancer (LRC) compared with mid/high rectal cancer (M/HRC).

    Authors: Hong Yang, Zhendan Yao, Ming Cui, Jiadi Xing, Chenghai Zhang, Nan Zhang, Maoxing Liu, Kai Xu, Fei Tan and Xiangqian Su

    Citation: BMC Cancer 2020 20:761

    Content type: Research article

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  13. Sintilimab blocks the interaction between programmed death-1 (PD-1) and its ligands. The safety and efficacy of sintilimab combined with oxaliplatin/capecitabine (CapeOx) as first-line treatment were evaluated...

    Authors: Haiping Jiang, Yulong Zheng, Jiong Qian, Chenyu Mao, Xin Xu, Ning Li, Cheng Xiao, Huan Wang, Lisong Teng, Hui Zhou, Shuyan Wang, Donglei Zhu, Bo Peng, Lin Shen and Nong Xu

    Citation: BMC Cancer 2020 20:760

    Content type: Research article

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  14. Few studies have examined gender differences in the clinical management of rectal cancer. We examine differences in stage at diagnosis and preoperative radiotherapy in rectal cancer patients.

    Authors: Cristina Sarasqueta, Mª Victoria Zunzunegui, José María Enríquez Navascues, Arrate Querejeta, Carlos Placer, Amaia Perales, Nerea Gonzalez, Urko Aguirre, Marisa Baré, Antonio Escobar and José María Quintana

    Citation: BMC Cancer 2020 20:759

    Content type: Research article

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  15. Despite the possible traumatic significance of cancer and of the incidence, prevalence, and survival of young women with breast cancer, these patients are underrepresented in multidimensional research. In the ...

    Authors: Barbara Muzzatti, Francesca Bomben, Cristiana Flaiban, Marika Piccinin and Maria Antonietta Annunziata

    Citation: BMC Cancer 2020 20:758

    Content type: Research article

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  16. Prostate cancer patients are known to suffer from poor sexual and urinary long-term side-effects following treatment, potentially impacting quality of life. The purpose of our study was to compare health-relat...

    Authors: Nadine Houédé, Xavier Rébillard, Sophie Bouvet, Sarah Kabani, Pascale Fabbro-Peray, Brigitte Trétarre and Florence Ménégaux

    Citation: BMC Cancer 2020 20:757

    Content type: Research article

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  17. Medulloblastoma is extremely rare in adults. The role of chemotherapy for average-risk adult patients remains controversial. Surgery and radiotherapy provide a significant disease control and a good prognosis,...

    Authors: E. Franceschi, S. Minichillo, A. Mura, A. Tosoni, M. Mascarin, C. Tomasello, S. Bartolini and A. A. Brandes

    Citation: BMC Cancer 2020 20:755

    Content type: Research article

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  18. Living donor liver transplantation (LDLT) is an acceptable treatment option for hepatocellular carcinoma (HCC). Traditional transplant criteria aim at best utilization of donor organs with low risk of post tra...

    Authors: Abu Bakar Hafeez Bhatti, Ammal Imran Qureshi, Rizmi Tahir, Faisal Saud Dar, Nusrat Yar Khan, Haseeb Haider Zia, Shahzad Riyaz and Atif Rana

    Citation: BMC Cancer 2020 20:754

    Content type: Research article

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  19. Ovarian tissue cryopreservation has a wide range of cancerous indications. Avoiding relapse becomes a specific concern that clinicians frequently encounter. The data about the comparative viability of cancer c...

    Authors: Xinxin Du, Plamen Todorov, Evgenia Isachenko, Gohar Rahimi, Peter Mallmann, Yuanguang Meng and Vladimir Isachenko

    Citation: BMC Cancer 2020 20:753

    Content type: Research article

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  20. The present study was conducted to determine the trend and projection of premature mortality from gastrointestinal cancers (GI cancers) at national and subnational levels in Iran.

    Authors: Fatemeh Khosravi Shadmani, Farshad Farzadfar, Moein Yoosefi, Kamyar Mansori, Reza Khosravi Shadman and Aliakbar Haghdoost

    Citation: BMC Cancer 2020 20:752

    Content type: Research article

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  21. The survival rates of women with breast cancer have improved significantly over the last four decades due to advances in breast cancer early diagnosis and therapy. However, breast cancer survivors have an incr...

    Authors: Zaid H. Maayah, Shingo Takahara, Abrar S. Alam, Mourad Ferdaoussi, Gopinath Sutendra, Ayman O. S. El-Kadi, John R. Mackey, Edith Pituskin, D. Ian Paterson and Jason R. B. Dyck

    Citation: BMC Cancer 2020 20:751

    Content type: Research article

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  22. NLR, PLR, and LMR have been associated with pancreatic ductal adenocarcinoma (PDAC) survival. Prognostic value and optimal cutpoints were evaluated to identify underlying significance in surgical PDAC patients.

    Authors: David T. Pointer Jr., David Roife, Benjamin D. Powers, Gilbert Murimwa, Sameh Elessawy, Zachary J. Thompson, Michael J. Schell, Pamela J. Hodul, Jose M. Pimiento, Jason B. Fleming and Mokenge P. Malafa

    Citation: BMC Cancer 2020 20:750

    Content type: Research article

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  23. Accumulating evidence has revealed the critical role of long non-coding RNAs (lncRNAs) in cellular processes during tumor progression. As documented in cancer-related literatures, LINC00992 expression is assoc...

    Authors: Jianheng Chen, Xiaodong Liu, Kunbin Ke, Jianan Zou, Zhan Gao, Tomonori Habuchi and Xuezhen Yang

    Citation: BMC Cancer 2020 20:749

    Content type: Research article

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  24. Tumors with deficient homologous repair are sensitive to PARP inhibitors such as olaparib which is known to have immunogenic properties. Durvalumab (D) is a human monoclonal antibody (mAb) which inhibits bindi...

    Authors: Jean-David Fumet, Emeric Limagne, Marion Thibaudin, Caroline Truntzer, Aurélie Bertaut, Emilie Rederstorff and Francois Ghiringhelli

    Citation: BMC Cancer 2020 20:748

    Content type: Study protocol

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  25. Hereditary breast and ovarian cancer (HBOC) is an autosomal dominant inherited cancer susceptibility disorder. Both BRCA1 and BRCA2 genes are considered as high penetrance genes of this syndrome. The identificati...

    Authors: Fatima Zahra El Ansari, Farah Jouali, Nabila Marchoudi, Mohcine Mechita Bennani, Naima Nourouti Ghailani, Amina Barakat and Jamal Fekkak

    Citation: BMC Cancer 2020 20:747

    Content type: Research article

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  26. Pregnancy-associated breast cancer (PABC) is defined as breast cancer that is diagnosed during pregnancy and/or the postpartum period. Definitions of the duration of the postpartum period have been controversi...

    Authors: Chunchun Shao, Zhigang Yu, Juan Xiao, Liyuan Liu, Fanzhen Hong, Yuan Zhang and Hongying Jia

    Citation: BMC Cancer 2020 20:746

    Content type: Research article

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  27. Anti-Androgen Receptor (AR) therapy holds promise for a subset of AR expressing triple-negative breast cancer (TNBC) patients. However, current AR assays are suboptimal in detecting the dynamic range of AR exp...

    Authors: Sindhu Govindan, Mallikarjuna Siraganahalli Eswaraiah, Chetana Basavaraj, Manjula Adinarayan, Satish Sankaran and Manjiri Bakre

    Citation: BMC Cancer 2020 20:745

    Content type: Research article

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  28. At the time of surgery, approximately 10–20% of the patients with pancreatic cancer are considered unresectable because of unexpected liver metastasis, peritoneal carcinomatosis or locally advanced disease. Th...

    Authors: G. Litjens, D. M. Rivière, E. J. M. van Geenen, S. A. Radema, L. A. A. Brosens, M. Prokop, C. J. H. M. van Laarhoven and J. J. Hermans

    Citation: BMC Cancer 2020 20:744

    Content type: Study protocol

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  29. The development and rapid uptake of immune checkpoint inhibitors (CPI) has changed the outlook for patients with cancer. However, CPIs have different adverse event (AE) profiles to other systemic therapies, an...

    Authors: Liz Jamieson, Martin D. Forster, Kam Zaki, Sanjena Mithra, Heena Alli, Anne O’Connor, Apini Patel, Ian C. K. Wong and Pinkie Chambers

    Citation: BMC Cancer 2020 20:743

    Content type: Research article

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  30. Several studies have reported the incidence of interstitial pneumonia (IP) among patients with non-Hodgkin lymphoma (NHL) that are undergoing combination chemotherapy plus rituximab; however, the effective pro...

    Authors: Cong Li, Fangxiao Lu, Tao Lei, Haifeng Yu, Xi Chen, Shuailing Peng, Shuiyun Han and Haiyan Yang

    Citation: BMC Cancer 2020 20:742

    Content type: Research article

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  31. The deubiquitinating (DUB) enzyme ubiquitin-specific protease 18 (USP18), also known as UBP43, is an ubiquitin-specific protease linked to several human malignancies. However, USP18’s underlying function in hu...

    Authors: Wenjing Diao, Qisang Guo, Caiying Zhu, Yu Song, Hua Feng, Yuankui Cao, Ming Du and Huifen Chen

    Citation: BMC Cancer 2020 20:741

    Content type: Research article

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  32. Precision oncology pharmacotherapy relies on precise patient-specific alterations that impact drug responses. Due to rapid advances in clinical tumor sequencing, an urgent need exists for a clinical support to...

    Authors: Quan Xu, Jin-Cheng Zhai, Cai-Qin Huo, Yang Li, Xue-Jiao Dong, Dong-Fang Li, Ru-Dan Huang, Chuang Shen, Yu-Jun Chang, Xi-Ling Zeng, Fan-Lin Meng, Fang Yang, Wan-Ling Zhang, Sheng-Nan Zhang, Yi-Ming Zhou and Zhi Zhang

    Citation: BMC Cancer 2020 20:740

    Content type: Software

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  33. Cancer-related fatigue represents one major cause of reduced quality of life in cancer patients and can seriously affect the physical, emotional, and cognitive functioning impeding coping with the disease. Opt...

    Authors: Ben Schöttker, Sabine Kuznia, Dana Clarissa Laetsch, David Czock, Annette Kopp-Schneider, Reiner Caspari and Hermann Brenner

    Citation: BMC Cancer 2020 20:739

    Content type: Study protocol

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  34. Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune con...

    Authors: Julian Ramelow, Christopher D. Brooks, Li Gao, Abeer A. Almiman, Terence M. Williams, Miguel A. Villalona-Calero and Wenrui Duan

    Citation: BMC Cancer 2020 20:738

    Content type: Research article

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  35. Disparities in multiple myeloma (MM) prognosis based on sociodemographic factors may exist. We investigated whether education level at diagnosis influenced Chinese MM patient outcomes.

    Authors: Limei Xu, Xiuju Wang, Xueyi Pan, Xiaotao Wang, Qing Wang, Bingyi Wu, Jiahui Cai, Ying Zhao, Lijuan Chen, Wuping Li and Juan Li

    Citation: BMC Cancer 2020 20:737

    Content type: Research article

    Published on:

  36. Seroma formation is a common complication after breast cancer surgery and can lead to delayed wound healing, infection, patient discomfort and repeated visits to the outpatient clinic. Mastectomy combined with...

    Authors: Lisa de Rooij, Sander M. J. van Kuijk, Els R. M. van Haaren, Alfred Janssen, Yvonne L. J. Vissers, Geerard L. Beets and James van Bastelaar

    Citation: BMC Cancer 2020 20:735

    Content type: Study protocol

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  37. Laryngocarcinoma (LC), in most cases a squamous cell carcinoma, accounts for 1 ~ 5% of the incidence of all tumors. At present, laryngocarcinoma is mainly managed with the integration of surgery and radio- and...

    Authors: Yining Yang, Li Li, Yongzhe Zheng, Qingfeng Liu, Xianfeng Wei, Xinyuan Gong, Wei Wang and Peng Lin

    Citation: BMC Cancer 2020 20:734

    Content type: Study protocol

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  38. Risk stratification and prognosis prediction of acute myeloid leukemia (AML) are largely dependent on pre-treatment information. However, post-treatment data also provides much useful information. In this retr...

    Authors: Yang Wang, Hua Wang, Weida Wang, Wenjian Liu, Nawei Liu, Shuang Liu and Yue Lu

    Citation: BMC Cancer 2020 20:732

    Content type: Research article

    Published on:

  39. Cancer cells induce the infiltration of various immune cells that are located or distributed in different sites and play multiple roles, which have recently been proposed to predict clinical outcomes. We there...

    Authors: Jie Wang, Shu Tian, Ji Sun, Jiahao Zhang, Lan Lin and Chunyan Hu

    Citation: BMC Cancer 2020 20:731

    Content type: Research article

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  40. Primary surgery is usually the mainstay treatment in early-stage oropharyngeal and oral cavity cancer. Typically, neck surgery is performed. Negative tumor margins are recommended (> 5 mm). If feasible, re-res...

    Authors: Julian Biau, Emilie Thivat, Corinne Millardet, Nicolas Saroul, Nathalie Pham-Dang, Ioana Molnar, Bruno Pereira, Xavier Durando, Jean Bourhis and Michel Lapeyre

    Citation: BMC Cancer 2020 20:730

    Content type: Study protocol

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  41. Uridine diphosphate glucuronosyltransferase 1 family polypeptide A1 (UGT1A1) is a predictive biomarker for the side-effects of irinotecan chemotherapy, which reduces the volume of tumors harboring UGT1A1 polymorp...

    Authors: Hideki Matsuoka, Ryusuke Murakami, Kaoru Abiko, Ken Yamaguchi, Akihito Horie, Junzo Hamanishi, Tsukasa Baba and Masaki Mandai

    Citation: BMC Cancer 2020 20:729

    Content type: Research article

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  42. Anti-PD1 inhibitors have been approved for the treatment of recurrent or metastatic head and neck cancer (HNC), as a result of Global Phase III trials. However, the clinical outcomes of immune checkpoint inhib...

    Authors: Hyera Kim, Minsuk Kwon, Binnari Kim, Hyun Ae Jung, Jong-Mu Sun, Se-Hoon Lee, Keunchil Park and Myung-Ju Ahn

    Citation: BMC Cancer 2020 20:727

    Content type: Research article

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  43. Previous reports indicate that the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism plays a role in gastric cancer. However, whether it influences the development and progression of atrophic g...

    Authors: Siya Kong, Feng Ye, Yini Dang, Yifei Hua and Guoxin Zhang

    Citation: BMC Cancer 2020 20:725

    Content type: Research article

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  44. Breast tumor initiating cells (BTIC) are stem-like cells that initiate and sustain tumor growth, and drive disease recurrence. Identifying therapies targeting BTIC has been hindered due primarily to their scar...

    Authors: William D. Gwynne, Mirza S. Shakeel, Adele Girgis-Gabardo, Kwang H. Kim, Emily Ford, Anna Dvorkin-Gheva, Craig Aarts, Methvin Isaac, Rima Al-awar and John A. Hassell

    Citation: BMC Cancer 2020 20:724

    Content type: Research article

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  45. To evaluate the impact of Gallium-68 [68Ga] labeled prostate specific membrane antigen (PSMA) positron emission tomography (PET)/X-ray computed tomography (CT) compared with conventional imaging on staging and cl...

    Authors: Maarten L. Donswijk, Pim J. van Leeuwen, Erik Vegt, Zing Cheung, Stijn W. T. P. J. Heijmink, Henk G. van der Poel and Marcel P. M. Stokkel

    Citation: BMC Cancer 2020 20:723

    Content type: Research article

    Published on:

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