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  1. MYC amplification or overexpression is common in Group 3 medulloblastoma and is associated with the worst prognosis. Recently, protein arginine methyl transferase (PRMT) 5 expression has been closely associate...

    Authors: Nagendra K. Chaturvedi, Sidharth Mahapatra, Varun Kesherwani, Matthew J. Kling, Mamta Shukla, Sutapa Ray, Ranjana Kanchan, Naveenkumar Perumal, Timothy R. McGuire, J. Graham Sharp, Shantaram S. Joshi and Don W. Coulter

    Citation: BMC Cancer 2019 19:1056

    Content type: Research article

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  2. There has been a sharp rise in the incidence of human papillomavirus (HPV) associated oropharyngeal squamous cell carcinoma (OPSCC) in many countries. Patients with HPV-positive OPSCC have a more favorable pro...

    Authors: Titaporn Nopmaneepaisarn, Napadon Tangjaturonrasme, Worawat Rawangban, Chanida Vinayanuwattikun, Somboon Keelawat and Andrey Bychkov

    Citation: BMC Cancer 2019 19:1050

    Content type: Research article

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  3. Despite much effort on the treatment of breast cancer over the decades, a great uncertainty regarding the appropriate molecular biomarkers and optimal therapeutic strategy still exists. This research was perfo...

    Authors: Chenjing Zhu, Otilia Menyhart, Balázs Győrffy and Xia He

    Citation: BMC Cancer 2019 19:1046

    Content type: Research article

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  4. Resistance to chemotherapy is one of the major hurdles in current cancer therapy. With the increasing occurrence of drug resistance, a paradigm shift in treatment strategy is required. Recently “medication vac...

    Authors: Divya Niveditha, Harshita Sharma, Syamantak Majumder, Sudeshna Mukherjee, Rajdeep Chowdhury and Shibasish Chowdhury

    Citation: BMC Cancer 2019 19:1045

    Content type: Research article

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  5. The receptor tyrosine kinases (RTKs) play critical roles in the development of cancers. Clear cell renal cell carcinoma (ccRCC) accounts for 75% of the RCC. The previous studies on the RTKs in ccRCCs mainly fo...

    Authors: Qing Zhang, Jian-He Liu, Jing-Li Liu, Chun-Ting Qi, Lei Yan, Yu Chen and Qiang Yu

    Citation: BMC Cancer 2019 19:1044

    Content type: Research article

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  6. Radiological imaging plays a central role in the diagnosis of breast cancer (BC). Some studies suggest MRI techniques like diffusion weighted imaging (DWI) may provide further prognostic value by discriminatin...

    Authors: Alexey Surov, Yun-Woo Chang, Lihua Li, Laura Martincich, Savannah C. Partridge, Jin You Kim and Andreas Wienke

    Citation: BMC Cancer 2019 19:1043

    Content type: Research article

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  8. The ultimate goal of locoregional therapy (LRT) to the liver is to induce total tumor necrosis. Trans-arterial chemoembolization (TACE) is the mainstay bridging therapy for patients with hepatocellular carcino...

    Authors: Wei Zhang, An-Hui Xu, Wei Wang, Yan-Hui Wu, Qian-Ling Sun and Chang Shu

    Citation: BMC Cancer 2019 19:1041

    Content type: Research article

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  9. The longevity for people with intellectual disability (ID) has significantly increased in developed countries during the past decades. Consequently, the incidence of cancer is expected to increase in this grou...

    Authors: Mikael Segerlantz, Anna Axmon, Rebecca Gagnemo Persson, Eva Brun and Gerd Ahlström

    Citation: BMC Cancer 2019 19:1040

    Content type: Research article

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  10. Understanding mechanisms underlying specific chemotherapeutic responses in subtypes of cancer may improve identification of treatment strategies most likely to benefit particular patients. For example, triple-...

    Authors: David P. Hill, Akeena Harper, Joan Malcolm, Monica S. McAndrews, Susan M. Mockus, Sara E. Patterson, Timothy Reynolds, Erich J. Baker, Carol J. Bult, Elissa J. Chesler and Judith A. Blake

    Citation: BMC Cancer 2019 19:1039

    Content type: Research article

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  11. Androgens, through their own receptor, play a protective role on breast tumor development and progression and counterbalance estrogen-dependent growth stimuli which are intimately linked to breast carcinogenesis.

    Authors: Francesca De Amicis, Chiara Chiodo, Catia Morelli, Ivan Casaburi, Stefania Marsico, Rosalinda Bruno, Diego Sisci, Sebastiano Andò and Marilena Lanzino

    Citation: BMC Cancer 2019 19:1038

    Content type: Research article

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  12. SMAD4 is frequently inactivated and associated with a poor prognosis in pancreatic ductal adenocarcinoma (PDAC). Abnormal SMAD4 expression also plays an important role in the malignant progression of PDAC.

    Authors: Zusen Wang, Yongxing Li, Shixiong Zhan, Lu Zhang, Shun Zhang, Qian Tang, Miaomiao Li, Zhen Tan, Shiguo Liu and Xiaoming Xing

    Citation: BMC Cancer 2019 19:1037

    Content type: Research article

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  13. The breast cancer microenvironment contributes to tumor progression and response to chemotherapy. Previously, we reported that increased stromal Type X collagen α1 (ColXα1) and low TILs correlated with poor pa...

    Authors: Chaohui Lisa Zhao, Kamaljeet Singh, Alexander S. Brodsky, Shaolei Lu, Theresa A. Graves, Mary Anne Fenton, Dongfang Yang, Ashlee Sturtevant, Murray B. Resnick and Yihong Wang

    Citation: BMC Cancer 2019 19:1036

    Content type: Research article

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  14. β-arrestin-2(Arr2) functions as an anti-apoptotic factor and affects cell proliferation, but its downstream molecular pathway in endometrial carcinoma (EC) is still unclear. This study aimed to investigate the...

    Authors: Fanling Hong, Yujun Zhang, Wenjin Cheng, Xiuli Sun and Jianliu Wang

    Citation: BMC Cancer 2019 19:1035

    Content type: Research article

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  16. Budding is a complementary prognostic factor for colorectal cancer. In this study, we aimed to clarify the role of tumor budding in rectal cancer patients after preoperative chemoradiotherapy.

    Authors: Iryna Trotsyuk, Halina Sparschuh, Alice Josephine Müller, Konrad Neumann, Martin Kruschewski, David Horst and Sefer Elezkurtaj

    Citation: BMC Cancer 2019 19:1033

    Content type: Research article

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  17. Patients with chemotherapy refractory metastatic colorectal cancer (CRC) have a poor prognosis and limited therapeutic options. In this phase Ib/II clinical trial, we established the maximum tolerated dose (MT...

    Authors: John H. Strickler, Christel N. Rushing, Donna Niedzwiecki, Abigail McLeod, Ivy Altomare, Hope E. Uronis, S. David Hsu, S. Yousuf Zafar, Michael A. Morse, David Z. Chang, James L. Wells, Kimberly L. Blackwell, P. Kelly Marcom, Christy Arrowood, Emily Bolch, Sherri Haley…

    Citation: BMC Cancer 2019 19:1032

    Content type: Research article

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  18. The deregulated alternative splicing of key glycolytic enzyme, Pyruvate Kinase muscle isoenzyme (PKM) is implicated in metabolic adaptation of cancer cells. The splicing switch from normal PKM1 to cancer-speci...

    Authors: Sandhya Yadav, Somnath D. Bhagat, Amit Gupta, Atul Samaiya, Aasheesh Srivastava and Sanjeev Shukla

    Citation: BMC Cancer 2019 19:1031

    Content type: Research article

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  19. The lack of predictive biomarkers or test systems contributes to high failure rates of systemic therapy in metastasized colorectal carcinoma, accounting for a still unfavorable prognosis. Here, we present an e...

    Authors: Steve Z. Martin, Daniel C. Wagner, Nina Hörner, David Horst, Hauke Lang, Katrin E. Tagscherer and Wilfried Roth

    Citation: BMC Cancer 2019 19:1030

    Content type: Research article

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  20. Infusion of high-dose intravenous methotrexate (MTX) has been demonstrating to penetrate the blood-brain barrier. The aim of this present study was to assess the efficacy and safety of high dose MTX in patient...

    Authors: F. Bazan, E. Dobi, B. Royer, E. Curtit, L. Mansi, N. Menneveau, M. J. Paillard, G. Meynard, C. Villanueva, X. Pivot and L. Chaigneau

    Citation: BMC Cancer 2019 19:1029

    Content type: Research article

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  21. Women with ovarian cancer can present with a variety of symptoms and signs, and an increasing range of tests are available for their investigation. A number of international guidelines provide advice for the i...

    Authors: Garth Funston, Marije Van Melle, Marie-Louise Ladegaard Baun, Henry Jensen, Charles Helsper, Jon Emery, Emma J. Crosbie, Matthew Thompson, Willie Hamilton and Fiona M. Walter

    Citation: BMC Cancer 2019 19:1028

    Content type: Research article

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  22. Nicotinamide phosphoribosyltransferase (NAMPT) enzyme acts as the major enzyme in the nicotinamide adenine dinucleotide (NAD) synthesis salvage pathway. Deregulation of NAD could be associated with progression...

    Authors: Zahra Bolandghamat Pour, Mitra Nourbakhsh, Kazem Mousavizadeh, Zahra Madjd, Seyedeh Sara Ghorbanhosseini, Zohreh Abdolvahabi, Zahra Hesari and Samira Ezzati Mobasser

    Citation: BMC Cancer 2019 19:1027

    Content type: Research article

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  23. In oncology, Health Care Professionals often experience conducting Advance Care Planning (ACP) conversations as difficult and are hesitant to start them. A structured approach could help to overcome this. In t...

    Authors: M. Zwakman, K. Pollock, F. Bulli, G. Caswell, B. Červ, J. J. M. van Delden, L. Deliens, A. van der Heide, L. J. Jabbarian, H. Koba-Čeh, U. Lunder, G. Miccinesi, C. A. Møller Arnfeldt, J. Seymour, A. Toccafondi, M. N. Verkissen…

    Citation: BMC Cancer 2019 19:1026

    Content type: Research article

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  24. Genetics-based basket trials have emerged to test targeted therapeutics across multiple cancer types. However, while vemurafenib is FDA-approved for BRAF-V600E melanomas, the non-melanoma basket trial was unsucce...

    Authors: Molly J. Carroll, Carl R. Parent, David Page and Pamela K. Kreeger

    Citation: BMC Cancer 2019 19:1025

    Content type: Research article

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  25. Research shows disparities in cancer outcomes by ethnicity or socio-economic status. Therefore, it is the aim of our study to perform a matched-pair analysis which compares the outcome of German and non-German...

    Authors: Marie K. Budde, Walther Kuhn, Mignon-Denise Keyver-Paik, Friedrich Bootz, Jörg C. Kalff, Stefan C. Müller, Thomas Bieber, Peter Brossart, Hartmut Vatter, Ulrich Herrlinger, Dieter C. Wirtz, Hans H. Schild, Glen Kristiansen, Thorsten Pietsch, Stefan Aretz, Franziska Geiser…

    Citation: BMC Cancer 2019 19:1024

    Content type: Research article

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  26. The aim of the present study was to assess the efficacy of postoperative chemoradiotherapy (POCRT) following surgery in non-small-cell lung cancer patients with N2 lymph node metastasis (N2-NSCLC).

    Authors: Liyu Su, Mingqiu Chen, Huiyan Su, Yaqing Dai, Shaoxing Chen and Jiancheng Li

    Citation: BMC Cancer 2019 19:1023

    Content type: Research article

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  27. The prognostic value of programmed death-ligand 1 (PD-L1) and BRAF expression in nasopharyngeal carcinoma (NPC) is not well-defined. In this study we investigated alterations in PD-L1, BRAF and EGFR by using i...

    Authors: Yabing Cao, Kin Iong Chan, Gungli Xiao, Yanqun Chen, Xibin Qiu, Hu Hao, Sao Chi Mak and Tongyu Lin

    Citation: BMC Cancer 2019 19:1022

    Content type: Research article

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  28. Recent preclinical data suggest that androgen receptor (AR) signaling plays a significant role in subsets of breast cancer. Clinical trials testing AR-targeting therapies in breast cancer have been conducted. ...

    Authors: Toru Hanamura, Koichi Ohno, Shinya Hokibara, Hideki Murasawa, Toshitsugu Nakamura, Hidehiko Watanabe, Machiko Kaizuka, Shinji Sawano, Hiroshi Koyama and Ken-ichi Ito

    Citation: BMC Cancer 2019 19:1021

    Content type: Research article

    Published on:

  29. Accumulating evidence suggests that Gamma-glutamyltransferase (GGT) may be involved in cancer occurrence and progression. However, the prognostic role of serum GGT in pancreatic cancer (PC) survival lacks adeq...

    Authors: Yuanyuan Xiao, Haijun Yang, Jian Lu, Dehui Li, Chuanzhi Xu and Harvey A. Risch

    Citation: BMC Cancer 2019 19:1020

    Content type: Research article

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  30. Nivolumab is an immune checkpoint inhibitor specific to the programmed death 1 (PD-1) receptor. Nivolumab has shown clinical responses in many malignancies. Although immune-related adverse events (irAEs) assoc...

    Authors: Koji Yoshino, Takayuki Nakayama, Ayumu Ito, Eiichi Sato and Shigehisa Kitano

    Citation: BMC Cancer 2019 19:1019

    Content type: Case report

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  31. Neuroblastoma (NB) is a frequent pediatric tumor associated with poor prognosis. The disregulation of Bcl-2, an anti-apoptotic protein, is crucial for the tumoral development and chemoresistance. Autophagy is ...

    Authors: Sonia Cournoyer, Anissa Addioui, Assila Belounis, Mona Beaunoyer, Carine Nyalendo, Roxane Le Gall, Pierre Teira, Elie Haddad, Gilles Vassal and Hervé Sartelet

    Citation: BMC Cancer 2019 19:1018

    Content type: Research article

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  32. Pre-clinical studies have shown that furosemide slows cancer cell growth by acting on the Na-K-2Cl transporter, particularly for gastric cancer cells. However, epidemiological studies have not investigated fur...

    Authors: Peipei Liu, Úna C. McMenamin, Andrew D. Spence, Brian T. Johnston, Helen G. Coleman and Chris R. Cardwell

    Citation: BMC Cancer 2019 19:1017

    Content type: Research article

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  33. Chemotherapy-induced alimentary mucositis (AM) is difficult to prevent and treatment is rarely effective. Recent study have been showed that glucagon-like peptide (GLP)-1 and GLP-2 has protective in chemothera...

    Authors: Jung Min Lee, In Kyung Yoo, Jae Min Lee, Seung Han Kim, Hyuk Soon Choi, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Soon Ho Um and Chang Duck Kim

    Citation: BMC Cancer 2019 19:1016

    Content type: Research article

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  35. Somatic PTEN mutation occurs in a proportion of ovarian endometrioid carcinomas. However, these cancers have seldom been reported in diseases associated with germline PTEN variants, such as Cowden syndrome (CS).

    Authors: Hiroyuki Matsubayashi, Satomi Higashigawa, Yoshimi Kiyozumi, Yasue Horiuchi, Yasuyuki Hirashima, Nobuhiro Kado, Masato Abe, Takuma Ohishi, Sumiko Ohnami, Kenichi Urakami and Ken Yamaguchi

    Citation: BMC Cancer 2019 19:1014

    Content type: Case report

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  36. The Host Cell Reactivation assay (HCR) allows studying the DNA repair capability in different types of human cells. This assay was carried out to assess the ability in removing UV-lesions from DNA, thus verify...

    Authors: Elisabetta Bassi, Paola Perucca, Isabella Guardamagna, Ennio Prosperi, Lucia A. Stivala and Ornella Cazzalini

    Citation: BMC Cancer 2019 19:1013

    Content type: Research article

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  38. Bone metastases in the lower spine and pelvis are effectively palliated with radiotherapy (RT), though this can come with side effects such as radiation induced nausea and vomiting (RINV). We hypothesize that ...

    Authors: Robert Olson, Roel Schlijper, Nick Chng, Quinn Matthews, Marco Arimare, Lindsay Mathews, Fred Hsu, Tanya Berrang, Alexander Louie, Benjamin Mou, Boris Valev, Joanna Laba, David Palma, Devin Schellenberg and Shilo Lefresne

    Citation: BMC Cancer 2019 19:1011

    Content type: Study protocol

    Published on:

  39. Analysis of molecular markers in addition to cytological analysis of fine-needle aspiration (FNA) samples is a promising way to improve the preoperative diagnosis of thyroid nodules. Nonetheless, in clinical p...

    Authors: Sergei E. Titov, Mikhail K. Ivanov, Pavel S. Demenkov, Gevork A. Katanyan, Eugenia S. Kozorezova, Anastasia V. Malek, Yulia A. Veryaskina and Igor F. Zhimulev

    Citation: BMC Cancer 2019 19:1010

    Content type: Research article

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  40. The high expression of BLM (Bloom syndrome) helicase in tumors involves its strong association with cell expansion. Bisbenzylisoquinoline alkaloids own an antitumor property and have developed as candidates fo...

    Authors: Wangming Zhang, Shuang Yang, Jinhe Liu, Linchun Bao, He Lu, Hong Li, Weidong Pan, Yanchao Jiao, Zhixu He and Jielin Liu

    Citation: BMC Cancer 2019 19:1009

    Content type: Research article

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  41. Many data suggest that patients with low rectal adenocarcinoma who achieved ypT0N0 status have improved survival and disease-free survival (DFS) compared to all other stages however only few data are available...

    Authors: Amine Souadka, Mohammed Anass Majbar, Amine Benkabbou, Badr Serji, Tarik Souiki, Sidi Mohammed Bouchentouf, Mourad Abid, Basma El Khannousi, Tijani El Harroudi, Hadj Omar El Malki, Mohammed Raiss, Lahsen Ifrine, Khalid Mazaz, Aziz Zentar, Raouf Mohsine, Abdelilah Souadka…

    Citation: BMC Cancer 2019 19:1008

    Content type: Research article

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  42. The expression of microRNAs (miRNAs) is a promising prognostic and diagnostic tool in hepatocellular carcinoma (HCC). Here we performed small RNA sequencing (sRNA-seq) of tissue, serum and serum exosomes to in...

    Authors: Robin Mjelle, Simona O. Dima, Nicolae Bacalbasa, Konika Chawla, Andrei Sorop, Dana Cucu, Vlad Herlea, Pål Sætrom and Irinel Popescu

    Citation: BMC Cancer 2019 19:1007

    Content type: Research article

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  43. Non-small cell lung cancer (NSCLC) patients harboring epidermal growth factor receptor (EGFR) mutations often develop brain metastases. Treatment with EGFR-tyrosine kinase inhibitors (TKIs) has shown the effec...

    Authors: Yung-Hsuan Chen, Yen-Fu Chen, Chung-Yu Chen, Jin-Yuan Shih and Chong-Jen Yu

    Citation: BMC Cancer 2019 19:1006

    Content type: Research article

    Published on:

  44. Acute T-cell lymphoblastic leukaemia (T-ALL) is an aggressive disorder derived from immature thymocytes. The variability observed in clinical responses on this type of tumours to treatments, the high toxicity ...

    Authors: Pablo Fernández-Navarro, Pilar López-Nieva, Elena Piñeiro-Yañez, Gonzalo Carreño-Tarragona, Joaquín Martinez-López, Raúl Sánchez Pérez, Ángel Aroca, Fátima Al-Shahrour, María Ángeles Cobos-Fernández and José Fernández-Piqueras

    Citation: BMC Cancer 2019 19:1005

    Content type: Research article

    Published on:

  45. The survival rate of patients with advanced oesophageal cancer is very low and can vary significantly, even among patients with the same TNM stage. It is important to look for indicators that are economical an...

    Authors: Ke-Jie Li, Xiao-Fang Xia, Meng Su, Hui Zhang, Wen-Hao Chen and Chang-Lin Zou

    Citation: BMC Cancer 2019 19:1004

    Content type: Research article

    Published on:

  46. In biomedical research, network inference algorithms are typically used to infer complex association patterns between biological entities, such as between genes or proteins, using data from a population. This ...

    Authors: Marieke L Kuijjer, Ping-Han Hsieh, John Quackenbush and Kimberly Glass

    Citation: BMC Cancer 2019 19:1003

    Content type: Software

    Published on:

  47. Amputation is the standard of care even for early-stage subungual melanomas (SUMs), known as nail apparatus melanoma, because the nail bed and nail matrix are close to the distal phalanx. However, a recent stu...

    Authors: Kiyo Tanaka, Yasuhiro Nakamura, Tomonori Mizutani, Taro Shibata, Arata Tsutsumida, Haruhiko Fukuda, Shigeto Matsushita, Megumi Aoki, Kenjiro Namikawa, Shuichi Ohe, Satoshi Fukushima and Naoya Yamazaki

    Citation: BMC Cancer 2019 19:1002

    Content type: Study protocol

    Published on:

  48. The objectives were to investigate the disparity in the prevalence of bone metastases (BM) between the sexes and to assess the effect of female sex on the development and prognosis of BM.

    Authors: Wenjuan Ma, Karl Peltzer, Lisha Qi, Guijun Xu, Zheng Liu, Jingyi Wang, Min Mao, Vladimir P. Chekhonin, Xin Wang and Chao Zhang

    Citation: BMC Cancer 2019 19:1001

    Content type: Research article

    Published on:

  49. Overexpression of epidermal growth factor receptor (EGFR) has been established as a valid therapeutic target of non-small cell lung cancer (NSCLC). However, the clinical benefit of cetuximab as an EGFR-targeti...

    Authors: Aiko Yamaguchi, Arifudin Achmad, Hirofumi Hanaoka, Yusri Dwi Heryanto, Anu Bhattarai, Ratianto, Erdene Khongorzul, Rini Shintawati, A. Adhipatria P. Kartamihardja, Ayaka Kanai, Yumi Sugo, Noriko S. Ishioka, Tetsuya Higuchi and Yoshito Tsushima

    Citation: BMC Cancer 2019 19:1000

    Content type: Research article

    Published on:

  50. The low data publication rate for Food and Drug Administration (FDA)-approved drugs, and discrepancies between FDA-submitted versus published data, remain a concern. We investigated the publication statuses of...

    Authors: Kenji Omae, Yuki Kataoka, Yasushi Tsujimoto, Yusuke Tsutsumi, Yosuke Yamamoto, Shunichi Fukuhara and Toshi A. Furukawa

    Citation: BMC Cancer 2019 19:998

    Content type: Research article

    Published on:

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