The co-occurrence of type 1 autoimmune pancreatitis (AIP) and pancreatic tumor (PaT) has been previously reported. Pure AIP cases have favorable prognosis and are primarily treated with steroids, while AIP cas...
Authors: Pei Xiang, Xiaoling Zhang, Chaoyang Wang, Yuejiao Lang, Ling Xu, Li Huang, Jingxian Shen and Shi-Ting Feng
Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby incr...
Authors: Agnieszka Jezierska-Drutel, Shireen Attaran, Barbara L. Hopkins, John J. Skoko, Steven A. Rosenzweig and Carola A. Neumann
Diets that restrict energy or macronutrient intake (e.g. fasting/ketogenic diets (KDs)) may selectively protect non-tumour cells during cancer treatment. Previous reviews have focused on a subset of dietary re...
Authors: Ellie Shingler, Rachel Perry, Alexandra Mitchell, Clare England, Claire Perks, Georgia Herbert, Andy Ness and Charlotte Atkinson
Endometrial cancer is the most common gynecological cancer. G-protein coupled receptor 64 (GPR64) belongs to a family of adhesion GPCRs and plays an important role in male fertility. However, the function of G...
Authors: Jong Il Ahn, Jung-Yoon Yoo, Tae Hoon Kim, Young Im Kim, Russell R. Broaddus, Ji Yeon Ahn, Jeong Mook Lim and Jae-Wook Jeong
Eradication of minimal residual disease (MRD), at the end of Fludarabine-Cyclophosphamide-Rituximab (FCR) treatment, is a validated surrogate marker for progression-free and overall survival in chronic lymphoc...
Authors: Martin Gauthier, Françoise Durrieu, Elodie Martin, Michael Peres, François Vergez, Thomas Filleron, Lucie Obéric, Fontanet Bijou, Anne Quillet Mary and Loic Ysebaert
Communication between health care provider and patients in oncology presents challenges. Communication skills training have been frequently developed to address those. Given the complexity of communication tra...
Authors: F. Fischer, S. Helmer, A. Rogge, J. I. Arraras, A. Buchholz, A. Hannawa, M. Horneber, A. Kiss, M. Rose, W. Söllner, B. Stein, J. Weis, P. Schofield and C. M. Witt
The association between oral contraceptive (OC) use and long-term mortality remains uncertain and previous studies have reported conflicting findings. We aim to assess the long-term impact of OC use on all-cau...
Authors: Ula Nur, Darline El Reda, Dana Hashim and Elisabete Weiderpass
Few diagnostic and prognostic biomarkers are available for head-and-neck squamous cell carcinoma (HNSCC). Long non-coding RNAs (lncRNAs) have shown promise as biomarkers in other cancer types and in some cases...
Authors: Madeleine Sassenberg, Johanna Droop, Wolfgang A. Schulz, Dimo Dietrich, Sophia Marie Loick, Constanze Wiek, Kathrin Scheckenbach, Nadine T. Gaisa and Michèle J. Hoffmann
Clinical features of Asian melanoma patients are distinct from those of Western patients. This study was designed to determine the molecular and clinical characteristics of Asian melanoma patients treated with...
Authors: Jiyun Lee, Su Jin Lee, Kyung Kim, Seung Tae Kim, Kee-Taek Jang and Jeeyun Lee
Protein kinase C iota (PKCι) and protein kinase C zeta (PKCζ) are two atypical protein kinase (aPKC) enzymes that contribute to cell proliferation and cancer development. The Hippo/YAP pathway is commonly disr...
Authors: Kyung-Hee Kim, Chaeuk Chung, Jin-Man Kim, Dahye Lee, Sang Yeon Cho, Tae Hee Lee, Hyun Jin Cho and Min-Kyung Yeo
The risk of lymph node positivity in early-stage colon cancer is a parameter that impacts therapeutic recommendations. However, little is known about the effect of age on lymph node positivity in colon cancer ...
To validate the utility of the chemokine ligand 12 (CXCL12) as prognostic marker in patients with localized and metastatic germ cell tumors (GCT).
Authors: Christian Daniel Fankhauser, Lisa Roth, Nico Christian Grossmann, Benedikt Kranzbühler, Daniel Eberli, Tullio Sulser, Holger Moch, Peter-Karl Bode, Joerg Beyer and Thomas Hermanns
Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasm...
Authors: Sridevi Hanaganahalli Basavaiah, Flora D. Lobo, Cheryl Sarah Philipose, Pooja K. Suresh, Saraswathy Sreeram, Hema Kini, Kausalya K. Sahu and Krishna Prasad
Alcohol consumption is associated with increased risk of breast cancer; however, its association with subsequent risk of breast cancer death is unclear.
Authors: Huiyan Ma, Kathleen E. Malone, Jill A. McDonald, Polly A. Marchbanks, Giske Ursin, Brian L. Strom, Michael S. Simon, Jane Sullivan-Halley, Leslie Bernstein and Yani Lu
The role of TGF-β1 in lymph node metastasis and lymphangiogenesis, one of the most important steps of gastric cancer dissemination, is largely unknown. The goal of this study was to investigate the role of TGF...
Authors: Kyung Ho Pak, Ki Cheong Park and Jae-Ho Cheong
We report an extremely rare case of vaginal clear cell carcinoma, which originated from the malignant transformation of vaginal adenosis without prenatal diethylstilbestrol (DES) exposure.
Authors: Lihong Pang, Lei Li, Lan Zhu, Jinghe Lang and Yalan Bi
To demonstrate that post-therapy pathological tumor volume (ypTV) should be considered as an independent prognostic factor in advanced gastric cancer (GC) patients who underwent neoadjuvant chemotherapy (NAC) ...
Authors: Xiaolong Tang, Qingsi He, Hui Qu, Guorui Sun, Jia Liu, Lei Gao, Jingbo Shi, Jianhong Ye and Yahang Liang
Histology is a traditional way to classify subtypes of thymoma, because of low cost and convenience. Yet, due to the diverse morphology of thymoma, this method increases the complexity of histopathologic class...
Authors: Liang-Chuan Lai, Qiang-Ling Sun, Yu-An Chen, Yi-Wen Hsiao, Tzu-Pin Lu, Mong-Hsun Tsai, Lei Zhu, Eric Y. Chuang and Wentao Fang
The real-world incidence of chronic liver damage after transarterial chemoembolization (TACE) is unclear. LiverT, a retrospective, observational study, assessed liver function deterioration after a single TACE...
Authors: Rebecca A. Miksad, Sadahisa Ogasawara, Fang Xia, Marc Fellous and Fabio Piscaglia
PALETTE is a phase 3 trial that demonstrated single-agent activity of pazopanib in advanced soft tissue sarcomas (aSTS). We performed retrospective subgroup analyses to explore potential relationships between ...
Authors: Axel Le Cesne, Sebastian Bauer, George D. Demetri, Guangyang Han, Luca Dezzani, Qasim Ahmad, Jean-Yves Blay, Ian Judson, Patrick Schöffski, Massimo Aglietta, Peter Hohenberger and Hans Gelderblom
The treatment strategy for brain metastasis (BM) in patients with epidermal growth factor receptor (EGFR) -mutant lung adenocarcinoma (LAC) remains controversial. In the present study, we compared the efficacy...
Authors: Yanxin Chen, Jianping Wei, Jing Cai and Anwen Liu
Febrile neutropenia (FN) is a serious complication of myelosuppressive chemotherapy. Clinical practice guidelines recommend routine prophylactic coverage with granulocyte colony-stimulating factor (G-CSF)—such...
Authors: Derek Weycker, Robin Doroff, Ahuva Hanau, Charles Bowers, Rajesh Belani, David Chandler, Alexander Lonshteyn, Mark Bensink and Gary H. Lyman
Roles of cancer stem cells and early growth response gene 1 (Egr1) in carcinogenesis have been extensively studied in lung cancer. However, the role of Egr1 in the metastasis of lung cancer remains undetermine...
Authors: Yin-Hsun Feng, Yu-Chu Su, Shuo-Fu Lin, Pey-Ru Lin, Chao-Liang Wu, Chao-Ling Tung, Chien-Feng Li, Gia-Shing Shieh and Ai-Li Shiau
This study aimed to investigate the prognostic value of volumetric parameters on 18F- fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in gastric-cancer patients, accor...
Authors: Guobing Liu, Yan Hu, Xi Cheng, Yan Wang, Yushen Gu, Tianshu Liu and Hongcheng Shi
Hepatitis B virus (HBV) is the major risk factor for hepatocellular carcinoma (HCC). The molecular mechanisms underlying HBV-associated HCC pathogenesis is still unclear. Genetic alterations in cancer-related ...
Authors: Fung-Yu Huang, Danny Ka-Ho Wong, Vivien Wai-Man Tsui, Wai-Kay Seto, Lung-Yi Mak, Tan-To Cheung, Keane K.-Y. Lai and Man-Fung Yuen
NETTER-1 trial demonstrated high efficacy and low toxicity of four cycles of Peptide Receptor Radionuclide Therapy (PRRT) in patients with metastasized NET. The present study evaluates the outcome of further P...
Authors: S. Rudisile, A. Gosewisch, V. Wenter, M. Unterrainer, G. Böning, F. J. Gildehaus, W. P. Fendler, C. J. Auernhammer, C. Spitzweg, P. Bartenstein, A. Todica and H. Ilhan
Inherited pathogenic variants in BRCA1 and BRCA2 are the most common causes of hereditary breast and ovarian cancer (HBOC). The risk of developing breast cancer by age 80 in women carrying a BRCA1 pathogenic vari...
Authors: Ilnaz Sepahi, Ulrike Faust, Marc Sturm, Kristin Bosse, Martin Kehrer, Tilman Heinrich, Kathrin Grundman-Hauser, Peter Bauer, Stephan Ossowski, Hana Susak, Raymonda Varon, Evelin Schröck, Dieter Niederacher, Bernd Auber, Christian Sutter, Norbert Arnold…
Data indicate that primary cutaneous melanomas are characterized by clonal heterogeneity associated with oncogenic drivers. Less data are available on the clonal changes occurring during melanoma progression. ...
Authors: V. Doma, S. Kárpáti, E. Rásó, T. Barbai and J. Tímár
The prognostic role of serum alkaline phosphatase (ALP) has been found in several kinds of solid malignant tumor, but has never been extensively discussed in pancreatic cancer, especially through the applicati...
Authors: Yuanyuan Xiao, Jian Lu, Wei Chang, Ying Chen, Xiaomei Li, Dehui Li, Chuanzhi Xu and Haijun Yang
Many patients diagnosed with oesophageal adenocarcinoma (OAC) present with advanced disease and approximately half present with metastatic disease. Patients with localised disease, who are managed with curativ...
Authors: Becky A. S. Bibby, Cecelia S. Miranda, John V. Reynolds, Christopher J. Cawthorne and Stephen G. Maher
In recent years, research on cancer predisposition germline variants has emerged as a prominent field. The identity of somatic mutations is based on a reliable mapping of the patient germline variants. In addi...
Authors: Roni Rasnic, Nadav Brandes, Or Zuk and Michal Linial
The most recent results of Global Cancer Statistics indicated that gastrointestinal cancers, including gastric, colorectal, esophageal, and liver cancers, are among the most commonly diagnosed cancers worldwid...
Authors: Mohammad Hossein Somi, Roya Dolatkhah, Sepideh Sepahi, Mina Belalzadeh, Shahnaz Naghashi and Mohammad Asghari Jafarabadi
The aim of this study was to compare the oncological outcomes and clinical efficacy of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) in patients with pancreatic ductal adeno...
Authors: Yu-Li Jiang, Ren-Chao Zhang and Yu-Cheng Zhou
Increasing evidence revealed that high expression level of lncRNA SNHG1 was associated with the unfavorable prognosis of cancer and maybe used as a valuable biomarker for cancer patients. The present meta->analys...
Numerous studies have highlighted that long non-coding RNAs (lncRNAs) can bind to microRNA (miRNA) sites as competing endogenous RNAs (ceRNAs), thereby affecting and regulating the expression of mRNAs and targ...
Authors: Rui-Sheng Zhou, En-Xin Zhang, Qin-Feng Sun, Zeng-Jie Ye, Jian-Wei Liu, Dai-Han Zhou and Ying Tang
Adjunct testosterone therapy improves lean body mass, quality of life, and physical activity in patients with advanced cancers; however, the effects of testosterone on cardiac morphology and function are unkno...
Authors: Jessica M. Scott, E. Lichar Dillon, Michael Kinsky, Albert Chamberlain, Susan McCammon, Daniel Jupiter, Maurice Willis, Sandra Hatch, Gwyn Richardson, Christopher Danesi, Kathleen Randolph, William Durham, Traver Wright, Randall Urban and Melinda Sheffield-Moore
Lung cancer in young patients is rare and has unique clinicopathological features. However, the molecular features of lung cancer in these patients are unclear. In this study, we aimed to describe the molecula...
Authors: Zhen Chen, Xiao Teng, Jing Zhang, Ke Huang, Qian Shen, He Cao, Huisong Luo, Yanting Yuan and Xiaodong Teng
There is a large amount of controversy about the best management of the mandible in oral squamous cell carcinoma (SCC), mainly owing to the inability to acquire accurate bone invasion status. Therefore, our go...
Authors: Wei Du, Qigen Fang, Yao Wu, Junfu Wu and Xu Zhang
Trastuzumab emtansine (Kadcyla®, T-DM1) is an antibody-drug conjugate used to treat HER2 (human epidermal growth factor receptor 2) overexpressing metastatic breast cancer. In this report, we present the first...
Authors: Chung Young Kim, Namju Kim, Ho-Kyung Choung and Sang In Khwarg
The mTOR/S6K1 signaling pathway is often activated in cervical cancer, and thus considered a molecular target for cervical cancer therapies. Inhibiting mTOR is cytotoxic to cervical cancer cells and creates a ...
Authors: Ki Hong Nam, Sang Ah Yi, Gibeom Nam, Jae Sung Noh, Jong Woo Park, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Kang Ro Lee, Hyun-Ju Park, Jaecheol Lee and Jeung-Whan Han
Multiple primary melanomas (MPM) occur up to 8% of patients with cutaneous malignant melanoma (CMM). They are often sporadic harbouring several somatic mutations, but also familial cases harbouring a CDKN2A germl...
Authors: Milena Casula, Panagiotis Paliogiannis, Fabrizio Ayala, Vincenzo De Giorgi, Ignazio Stanganelli, Mario Mandalà, Maria Colombino, Antonella Manca, Maria Cristina Sini, Corrado Caracò, Paolo Antonio Ascierto, Rosanna Rita Satta, Amelia Lissia, Antonio Cossu and Giuseppe Palmieri
Long non-coding RNAs (lncRNAs) represent a substantial portion of the human transcriptome. LncRNAs present a very stringent cell-type/tissue specificity being potential candidates for therapeutical application...
Authors: Carla Pereira Gomes, Sandrina Nóbrega-Pereira, Beatriz Domingues-Silva, Kenny Rebelo, Catarina Alves-Vale, Sérgio Pires Marinho, Tânia Carvalho, Sérgio Dias and Bruno Bernardes de Jesus
Etoposide (E) at 100 mg/m2 combined with Cisplatin (P) at 20 mg/m2 represents an induction 2-day regimen embedded in our clinical practice for patients with advanced GCT or TN at high risk of early death. We eval...
Authors: Charleen Chan Wah Hak, Christopher Coyle, Arwa Kocache, Dee Short, Naveed Sarwar, Michael J. Seckl and Michael A. Gonzalez
ROS1 rearrangements are validated drivers in lung cancer, which have been identified in a small subset (1–2%) of patients with non-small cell lung cancer (NSCLC). To date, 18 fusion genes of ROS1 have been identi...
Authors: Shuguang Xu, Wenxian Wang, Chunwei Xu, Xingliang Li, Junhui Ye, Youcai Zhu and Ting Ge
Human papillomavirus is recognized as a major cause of cervical cancer. It is estimated that annually, 7,095 women are diagnosed with cervical cancer and 4,732 die from the disease in Ethiopia. Understanding that...
Authors: Kirubel Eshetu Ali, Ibrahim Ali Mohammed, Mesfin Nigussie Difabachew, Dawit Solomon Demeke, Tasew Haile, Robert-Jan ten Hove, Tsegaye Hailu Kumssa, Zufan Lakew Woldu, Eshetu Lemma Haile and Kassu Desta Tullu
Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analys...
Authors: Jiarui Xiao, Yizi Jin, Ji Nie, Fukun Chen and Xuelei Ma
To describe the patterns of second-line treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) after docetaxel treatment in a Spanish population, to identify the factors associated ...
Authors: Javier Puente, Aranzazu González-del-Alba, Núria Sala-Gonzalez, María José Méndez-Vidal, Alvaro Pinto, Ángel Rodríguez, José Miguel Cuevas Sanz, Jacobo Rodrigo Muñoz del Toro, Eduardo Useros Rodríguez, Ángela García García-Porrero and Sergio Vázquez
Worldwide, over 500,000 people are diagnosed with head and neck cancer each year, a disease with major impact on life expectancy and quality of life. The purpose of the Netherlands Quality of life and Biomedic...
Authors: I.M. Verdonck-de Leeuw, F. Jansen, R. H. Brakenhoff, J. A. Langendijk, R. Takes, C. H. J. Terhaard, R. J. Baatenburg de Jong, J. H. Smit and C. R. Leemans
MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers. A plethora of drugs wer...
Authors: Ning Wang, Yanhua Fan, Chun-Mao Yuan, Jialei Song, Yao Yao, Wuling Liu, Babu Gajendran, Eldad Zacksenhaus, Yanmei Li, Jielin Liu, Xiao Jiang Hao and Yaacov Ben-David
