Articles

Expression of FSCN1 and FOXM1 are associated with poor prognosis of adrenocortical carcinoma patients

Adrenocortical carcinoma (ACC) is a rare malignant endocrine tumour. Due to a high tumour recurrence rate, the post-operative overall survival (OS) and disease-free survival (DFS) of ACCs is limited. Our resea...

Authors: Jiayu Liang, Zhihong Liu, Xin Wei, Liang Zhou, Yongquan Tang, Chuan Zhou, Kan Wu, Fuxun Zhang, Fan Zhang, Yiping Lu and Yuchun Zhu

Radiotherapy for metastatic spinal cord compression with increased radiation doses (RAMSES-01): a prospective multicenter study

Patients with metastatic spinal cord compression (MSCC) and favorable survival prognoses can benefit from radiation doses greater than 30Gy in 10 fractions in terms of improved local progression-free survival ...

Authors: Dirk Rades, Olfred Hansen, Lars Henrik Jensen, Liesa Dziggel, Christian Staackmann, Claudia Doemer, Jon Cacicedo, Antonio J. Conde-Moreno, Barbara Segedin, Raquel Ciervide-Jurio, Carmen Rubio-Rodriguez, Luis A. Perez-Romasanta, Ana Alvarez-Gracia, Kristopher Dennis, Carlos Ferrer-Albiach, Arturo Navarro-Martin…

Conventional versus drug-eluting beads chemoembolization for infiltrative hepatocellular carcinoma: a comparison of efficacy and safety

To compare the efficacy and safety between conventional transarterial chemoembolization (cTACE) and drug-eluting beads TACE (DEB-TACE) in patients with infiltrative hepatocellular carcinoma (iHCC).

Authors: Zi-shu Zhang, Hui-zhou Li, Cong Ma and Yu-dong Xiao

Prognostic role of pre-treatment C-reactive protein/albumin ratio in esophageal cancer: a meta-analysis

In recent years, the role of pre-treatment C-reactive protein/albumin ratio (CAR) in prognosis of esophageal cancer (EC) has been investigated by several studies. This meta-analysis aimed to provide a more acc...

Authors: Zhenhua Liu, Hongtai Shi and Longyun Chen

Syndecan-1 suppresses cell growth and migration via blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells

Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is confirmed to participate in several tumor cell biological processes. However, the biological significance of SDC-1 in colorectal carcinoma is not...

Authors: Shaojun Wang, Xiaofei Zhang, Guimei Wang, Bin Cao, Hong Yang, Lipeng Jin, Mingjuan Cui and Yongjun Mao

MPPa-PDT suppresses breast tumor migration/invasion by inhibiting Akt-NF-κB-dependent MMP-9 expression via ROS

Breast cancer is one of the most commonly diagnosed cancers in women, with high morbidity and mortality. Tumor metastasis is implicated in most breast cancer deaths; thus, inhibiting metastasis may provide a t...

Authors: Liyi Huang, Haidan Lin, Qing Chen, Lehua Yu and Dingqun Bai

Topoisomerase I activity and sensitivity to camptothecin in breast cancer-derived cells: a comparative study

Camptothecin (CPT) and its derivatives are currently used as second- or third-line treatment for patients with endocrine-resistant breast cancer (BC). These drugs convert nuclear enzyme DNA topoisomerase I (TO...

Authors: Cinzia Tesauro, Anne Katrine Simonsen, Marie Bech Andersen, Kamilla Wandsoe Petersen, Emil Laust Kristoffersen, Line Algreen, Noriko Yokoyama Hansen, Anne Bech Andersen, Ann Katrine Jakobsen, Magnus Stougaard, Pavel Gromov, Birgitta R. Knudsen and Irina Gromova

LINC01128 expedites cervical cancer progression by regulating miR-383-5p/SFN axis

Cervical cancer (CC), causing significant morbidity and mortality worldwide, is one of the most common gynecological malignancies in women. SFN has been reported as a potential prognostic marker with apparent ...

Authors: Yi Hu, Yan Ma, Jie Liu, Yanlin Cai, Mengmeng Zhang and Xiaoling Fang

Prognostic factors and a new scoring system for survival of patients irradiated for bone metastases

Personalized therapy for bone metastases should consider the patients’ remaining lifespan. Estimation of survival can be facilitated with scoring tools. A new tool was developed, specifically designed to estim...

Authors: Dirk Rades, Rapha Haus, Steven E. Schild and Stefan Janssen

Molecular subtyping improves prognostication of Stage 2 colorectal cancer

Post-surgical staging is the mainstay of prognostic stratification for colorectal cancer (CRC). Here, we compare TNM staging to consensus molecular subtyping (CMS) and assess the value of subtyping in addition...

Authors: Rachel V. Purcell, Sebastian Schmeier, Yee Chen Lau, John F. Pearson and Francis A. Frizelle

First report of pulmonary sclerosing pneomucytoma with malignant transformation in both cuboidal surface cells and stromal round cells: a case report

Pulmonary sclerosing pneumocytoma (PSP) is a rare benign tumor. Although lymph node metastasis has been reported, it is still considered benign. No malignant transformation has been reported. This is the first...

Authors: Xiao Teng and Xiaodong Teng

Low lean mass and chemotherapy toxicity risk in the elderly: the Fraction study protocol

Half of cancer cases occur in patients aged 70 and above. Majority of older patients are eligible for chemotherapy but evidence for treating this population is sparse and severe toxicities affect more than hal...

Authors: Zara Steinmeyer, Stéphane Gérard, Thomas Filleron, Stéphanie Lozano, Delphine Brechemier, Gabor Abellan Van Kan, Loic Mourey, Laurence Cristol-Dalstein, Laure De Decker, Yves Rolland and Laurent Balardy

Detection of carcinogen-induced bladder cancer by fluorocoxib A

Conventional cystoscopy can detect advanced stages of bladder cancer; however, it has limitations to detect bladder cancer at the early stages. Fluorocoxib A, a rhodamine-conjugated analog of indomethacin, is ...

Authors: Jennifer Bourn, Kusum Rathore, Robert Donnell, Wesley White, Md. Jashim Uddin, Lawrence Marnett and Maria Cekanova

Redefining chemotherapy-induced peripheral neuropathy through symptom cluster analysis and patient-reported outcome data over time

Chemotherapy-induced peripheral neuropathy (CIPN) is common among cancer patients treated with neurotoxic chemotherapy agents. Better knowledge on symptom clusters of CIPN may help improve symptom management i...

Authors: Mian Wang, Hui Lin Cheng, Violeta Lopez, Raghav Sundar, Janelle Yorke and Alex Molassiotis

Clinical and imaging features of myeloid sarcoma: a German multicenter study

Myeloid sarcoma (MS), also known as chloroma, is an extramedullary manifestation of malignant primitive myeloid cells. Previously, only small studies investigated clinical and imaging features of MS. The purpo...

Authors: Hans-Jonas Meyer, Wolfram Pönisch, Stefan Andreas Schmidt, Susanne Wienbeck, Friederike Braulke, Dominik Schramm and Alexey Surov

Neurolymphomatosis of the lumbosacral plexus and its branches: case series and literature review

Neurolymphomatosis (NL) is a direct process of invasion of peripheral nerves by lymphoma. It occurs in roughly 5% of patients with lymphoma and represents a particularly difficult diagnostic dilemma when it is...

Authors: Pierre R. Bourque, Marcos Loreto Sampaio, Jodi Warman-Chardon, Sam Samaan and Carlos Torres

Increased risk of lymphoid malignancy in patients with herpes zoster: a longitudinal follow-up study using a national cohort

The association between herpes zoster and the risk of lymphoid neoplasms in Asian populations has not yet been established. We performed a longitudinal follow-up study using a nationwide cohort to assess the r...

Authors: Hyo Geun Choi, James L. Zehnder, Young Kyung Lee, Hyun Lim and Miyoung Kim

B-cell acute lymphoblastic leukemia in an elderly man with plasma cell myeloma and long-term exposure to thalidomide and lenalidomide: a case report and literature review

The advent of the immunomodulatory imide drugs (IMiDs) lenalidomide and thalidomide for the treatment of patients with plasma cell myeloma (PCM), has contributed to more than a doubling of the overall survival...

Authors: Ryan B. Sinit, Dick G. Hwang, Prakash Vishnu, Jess F. Peterson and David M. Aboulafia

Dual time point ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography fusion imaging (¹⁸F-FDG PET/CT) in primary breast cancer

To evaluate the clinicopathological and prognostic significance of the percentage change between maximum standardized uptake value (SUV_max) at 60 min (SUV_max1) and SUV_max at 120 min (SUV_max2) (ΔSUV_max%) using dua...

Authors: Yoji YAMAGISHI, Tomomi KOIWAI, Tamio YAMASAKI, Takahiro EINAMA, Makiko FUKUMURA, Miyuki HIRATSUKA, Takako KONO, Katsumi HAYASHI, Jiro ISHIDA, Hideki UENO and Hitoshi TSUDA

Genetic and clinical characterization of BRCA-associated hereditary breast and ovarian cancer in Navarra (Spain)

Genetic testing for BRCA1/2 genes is widely used as a strategy to reduce incidence and morbidity of hereditary breast and ovarian cancer (HBOC). The purpose of this study is to analyse the demographic and molecul...

Authors: Ainara Ruiz de Sabando, Edurne Urrutia Lafuente, Fermín García-Amigot, Angel Alonso Sánchez, Lourdes Morales Garofalo, Sira Moreno, Eva Ardanaz and Maria A. Ramos-Arroyo

Dose-volume parameters predict radiation pneumonitis after induction chemoradiotherapy followed by surgery for non-small cell lung cancer: a retrospective analysis

The relationship between lung dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) associated with induction concurrent chemoradiotherapy (CCRT) followed by surgery in patients with non-small ...

Authors: Kuniaki Katsui, Takeshi Ogata, Kenta Watanabe, Norihisa Katayama, Junichi Soh, Masahiro Kuroda, Katsuyuki Kiura, Yoshinobu Maeda, Shinichi Toyooka and Susumu Kanazawa

Biopsychosocial and clinical characteristics in patients with resected breast and colon cancer at the beginning and end of adjuvant treatment

The aim of this study was to analyze biopsychosocial factors affecting how patients cope with cancer and adjuvant treatment and to appraise psychological distress, coping, perceived social support, quality of ...

Authors: Teresa García-García, Alberto Carmona-Bayonas, Paula Jimenez-Fonseca, Carlos Jara, Carmen Beato, Beatriz Castelo, Montserrat Mangas, Eva Martínez de Castro, Avinash Ramchandani, David Gomez and Caterina Calderón

β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells

Chronic stress is well known to promote tumor progression, however, little is known whether chronic stress-mediated regulation of osteoblasts contributes to the migration and invasion of metastatic cancer cells.

Authors: Zhibin Huang, Guihuan Li, Zhishuai Zhang, Ruonan Gu, Wenyang Wang, Xiaoju Lai, Zhong-Kai Cui, Fangyin Zeng, Shiyuan Xu and Fan Deng

Impact of early chimerism status on clinical outcome in children with acute lymphoblastic leukaemia after haematopoietic stem cell transplantation

The significance of very early chimerism assessment before day + 28, which is considered the moment of engraftment, is still unclear. In this retrospective study, we evaluated the clinical impact of very early...

Authors: Monika Lejman, Agnieszka Zaucha-Prażmo, Joanna Zawitkowska, Aleksandra Mroczkowska, Dominik Grabowski, Jerzy R. Kowalczyk and Katarzyna Drabko

CYR61, a potential biomarker of tumor inflammatory response in epithelial ovarian cancer microenvironment of tumor progress

Recent studies have found that inflammatory response is involved in the pathogenesis of ovarian cancer. Advanced ovarian cancer is often presented with ascites that is rich in cytokines, inflammatory factors o...

Authors: Jun Shi, Rongfen Huo, Ningli Li, Haichuan Li, Tianhang Zhai, Huidan Li, Baihua Shen, Jing Ye, Ruojin Fu and Wen Di

Growth rates of malignant and benign thyroid nodules in an ultrasound follow-up study: a retrospective cohort study

Thyroid nodules are frequently detected by cervical ultrasound examinations. In follow-up studies, malignant as well as benign nodules may exhibit an increase in size.

Authors: Michael Cordes, Theresa Ida Götz, Karen Horstrup, Torsten Kuwert and Christian Schmidkonz

Evaluation of an online knowledge translation intervention to promote cancer risk reduction behaviours: findings from a randomized controlled trial

Many cancers are preventable through lifestyle modification; however, few adults engage in behaviors that are in line with cancer prevention guidelines. This may be partly due to the mixed messages on effectiv...

Authors: Sarah E. Neil-Sztramko, Emily Belita, Anthony J. Levinson, Jennifer Boyko and Maureen Dobbins

Nrf2 gene mutation and single nucleotide polymorphism rs6721961 of the Nrf2 promoter region in renal cell cancer

Nuclear factor erythroid 2–related factor 2 (Nrf2) is involved in cell proliferation by promotion of metabolic activity. It is also the major regulator of antioxidants and has a pivotal role in tumor cell prol...

Authors: Yoshiyuki Yamaguchi, Takao Kamai, Satoru Higashi, Satoshi Murakami, Kyoko Arai, Hiromichi Shirataki and Ken-Ichiro Yoshida

Preoperative risk stratification for early recurrence of HBV-related hepatocellular carcinoma after deceased donor liver transplantation: a five-eight model development and validation

Early recurrence of hepatocellular carcinoma (HCC) after liver transplantation (LT) is associated with poor surgical outcomes. This study aims to construct a preoperative model to predict individual risk of po...

Authors: Abdulahad Abdulrab Mohammed Al-Ameri, Xuyong Wei, Lidan Lin, Zhou Shao, Haijun Guo, Haiyang Xie, Lin Zhou, Shusen Zheng and Xiao Xu

Application of contrast-enhanced ultrasonography in the diagnosis of post-kidney transplant lymphoproliferative disorder in native kidney- a case report

Post-transplant lymphoproliferative disorders (PTLDs) represent a spectrum of heterogenetic lymphoid proliferations. PTLD is a serious complication that affects the long-term survival of kidney transplant pati...

Authors: Jian-Chao Zhang, Hui-Xia Lan, Hui-Juan Zhao, Yang-Yang Lei, Li Ma, Xiao-Yan Xie, Ming-de Lu and Wei Wang

The role of vascular mimicry as a biomarker in malignant melanoma: a systematic review and meta-analysis

Vasculogenic mimicry (VM) a microvascular system consisting of non-endothelial cells that is newly formed by aggressive tumors, has been proposed as an important therapeutic target in malignant melanoma (MM). ...

Authors: Zhenhua Zhang, Saber Imani, Marzieh Dehghan Shasaltaneh, Hossein Hosseinifard, Linglin Zou, Yu Fan and Qinglian Wen

Study protocol of a phase II clinical trial of oral metformin for the intravesical treatment of non-muscle invasive bladder cancer

Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of the urinary tract and requires life-long invasive surveillance to detect disease recurrence. Currently, there are no effective oral the...

Authors: Remco J. Molenaar, Jons W. van Hattum, Iris S. Brummelhuis, Jorg R. Oddens, C. Dilara Savci-Heijink, Egbert R. Boevé, Saskia A. van der Meer, J. Fred Witjes, Michael N. Pollak, Theo M. de Reijke and Johanna W. Wilmink

Smoking related lung cancer mortality by education and sex in Norway

Authors: Merethe S. Hansen, Idlir Licaj, Tonje Braaten, Arnulf Langhammer, Loic Le Marchand and Inger Torhild Gram

Detection of disseminated tumor cells in bone marrow predict late recurrences in operable breast cancer patients

Operable breast cancer patients may experience late recurrences because of reactivation of dormant tumor cells within the bone marrow (BM). Identification of patients who would benefit from extended therapy is...

Authors: Kjersti Tjensvoll, Oddmund Nordgård, Maren Skjæveland, Satu Oltedal, Emiel A. M. Janssen and Bjørnar Gilje

MicroRNAs in Pancreatic Cancer: biomarkers, prognostic, and therapeutic modulators

A severe lack of early diagnosis coupled with resistance to most available therapeutic options renders pancreatic cancer as a major clinical concern. The limited efficacy of current treatments necessitates the...

Authors: Afra Z. Daoud, Eoghan J. Mulholland, Grace Cole and Helen O. McCarthy

Methodology of predicting novel key regulators in ovarian cancer network: a network theoretical approach

Identification of key regulator/s in ovarian cancer (OC) network is important for potential drug target and prevention from this cancer. This study proposes a method to identify the key regulators of this netw...

Authors: Md. Zubbair Malik, Keilash Chirom, Shahnawaz Ali, Romana Ishrat, Pallavi Somvanshi and R. K. Brojen Singh

Association of TM6SF2 rs58542926 T/C gene polymorphism with hepatocellular carcinoma: a meta-analysis

Hepatocellular carcinoma (HCC) is the sixth-most common malignancy worldwide. Multiple previous studies have assessed the relationship between TM6SF2 gene polymorphism and the risk of developing HCC, with disc...

Authors: Shan Tang, Jing Zhang, Ting-Ting Mei, Hai-Qing Guo, Xin-Huan Wei, Wen-Yan Zhang, Ya-Li Liu, Shan Liang, Zuo-Peng Fan, Li-Xia Ma, Wei Lin, Yi-Rong Liu, Li-Xia Qiu and Hai-Bin Yu

Exploring the value of new preoperative inflammation prognostic score: white blood cell to hemoglobin for gastric adenocarcinoma patients

The platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and neutrophil to lymphocyte ratio (NLR) reflect the systematic inflammatory response, with some evidence revealing that they are ass...

Authors: Hua-Long Zheng, Jun Lu, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ju-Li Lin, Ping Li, Chao-Hui Zheng and Chang-Ming Huang

Synergism of wt-p53 and synthetic material in local nano-TAE gene therapy of hepatoma: comparison of four systems and the possible mechanism

TAE-gene therapy for hepatoma, incorporating the tumor-targeted therapeutic efficacy of trans-arterial embolization, hydroxyapatite nanoparticles (nHAP) and anti-cancer wild-type p53 gene (wt-p53), was present...

Authors: Gaopeng Li, Wenqin Kang, Mingliang Jin, Lidong Zhang, Jian Zheng, Kai Jia, Jinfeng Ma, Ting Liu, Xueyi Dang, Zhifeng Yan, Zefeng Gao and Jun Xu

A comparison between triplet and doublet chemotherapy in improving the survival of patients with advanced gastric cancer: a systematic review and meta-analysis

Chemotherapy can improve the survival of patients with advanced gastric cancer. However, whether triplet chemotherapy can further improve the survival of patients with advanced gastric cancer compared with dou...

Authors: Xinjian Guo, Fuxing Zhao, Xinfu Ma, Guoshuang Shen, Dengfeng Ren, Fangchao Zheng, Feng Du, Ziyi Wang, Raees Ahmad, Xinyue Yuan, Junhui Zhao and Jiuda Zhao

The oncogene Gankyrin is expressed in testicular cancer and contributes to cisplatin sensitivity in embryonal carcinoma cells

Testicular germ cell cancer (TGCC) develops from pre-malignant germ neoplasia in situ (GCNIS) cells. GCNIS originates from fetal gonocytes (POU5F1⁺/MAGE-A4⁻), which fail to differentiate to pre-spermatogonia (POU...

Authors: Maria E. Camacho-Moll, Joni Macdonald, L. H. J. Looijenga, Michael P. Rimmer, Roland Donat, John A. Marwick, C. J. Shukla, Neil Carragher, Anne Jørgensen and Rod T. Mitchell

The association between hypoxia inducible factor 1 subunit alpha gene rs2057482 polymorphism and cancer risk: a meta-analysis

The rs2057482 polymorphism in the hypoxia inducible factor 1 subunit alpha (HIF1A) gene has been reported to be associated with a risk of several types of cancer, but this association has not yet been definitivel...

Authors: Li-Fang Wu, Gui-Ping Xu, Qing Zhao, Li-Jing Zhou, Ding Wang and Wei-Xian Chen

The long-term survival of patients with III-IVb stage nasopharyngeal carcinoma treated with IMRT with or without Nimotuzumab: a propensity score-matched analysis

To assess the efficacy of Nimotuzumab in combination with first-line chemoradiotherapy treatment in Chinese patients with primary III-IVb stage nasopharyngeal carcinoma.

Authors: Wang Zhi-Qiang, Mei Qi, Li Ji-Bin, You Rui, Liu You-Ping, Sun Rui, Hu Guang-Yuan, Chen Ming-Yuan and Hua Yi-Jun

Comparative transcriptome analysis of matched primary and distant metastatic ovarian carcinoma

High grade serous ovarian carcinoma (HGSOC) is the most common subtype of epithelial ovarian cancers (EOC) with poor prognosis. In most cases EOC is widely disseminated at the time of diagnosis. Despite the op...

Authors: H. Sallinen, S. Janhonen, P. Pölönen, H. Niskanen, O. H. Liu, A. Kivelä, J. M. Hartikainen, M. Anttila, M. Heinäniemi, S. Ylä-Herttuala and M. U. Kaikkonen

Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study

Kidney transplantation (KT) correlates with an increased risk of developing several malignancies; however, the risk of colorectal cancer (CRC) after KT remains debatable and has been marginally explored. Hence...

Authors: Han-En Wang, Yu-Chan Liao, Je-Ming Hu, Wen-Chih Wu, Wan-Yun Chou, Yong-Chen Chen, Yu-Ching Chou, Chi-Feng Hung, Yu-Feng Tian, San-Lin You and Chien-An Sun

Gastrointestinal stromal tumor with intracranial metastasis: case presentation and systematic review of literature

Intracranial metastasis of Gastrointestinal Stromal Tumors (GISTs) is rare but presents unique treatment challenges. We present a case of intracranial metastasis of GIST with a systematic review of the literat...

Authors: Marc Prablek, Visish M. Srinivasan, Aditya Srivatsan, Stephanie Holdener, Mazen Oneissi, Kent A. Heck, Ali Jalali, Jacob Mandel, Ashwin Viswanathan and Akash J. Patel

ACRNaCT trial protocol: efficacy of adjuvant chemotherapy in patients with clinical T3b/T4, N+ rectal Cancer undergoing Neoadjuvant Chemoradiotherapy: a pathology-oriented, prospective, multicenter, randomized, open-label, parallel group clinical trial

The CAO/ARO/AIO-94 demonstrated that neoadjuvant chemoradiotherapy (CRT) could decrease the rate of local recurrence rather than distal metastases in advanced rectal cancer. Adjuvant chemotherapy (ACT) can eli...

Authors: Qingguo Li, Dakui Luo, Ji Zhu, Lifeng Yang, Qi Liu, Yanlei Ma, Lei Liang, Sanjun Cai, Zhen Zhang and Xinxiang Li

A gene expression-based study on immune cell subtypes and glioma prognosis

Glioma is a common malignant tumours in the central nervous system (CNS), that exhibits high morbidity, a low cure rate, and a high recurrence rate. Currently, immune cells are increasingly known to play roles...

Authors: Qiu-Yue Zhong, Er-Xi Fan, Guang-Yong Feng, Qi-Ying Chen, Xiao-Xia Gou, Guo-Jun Yue and Gui-hai Zhang

Whole lesion histogram analysis of apparent diffusion coefficients on MRI predicts disease-free survival in locally advanced squamous cell cervical cancer after radical chemo-radiotherapy

The aim was to investigate the prognostic value of MR apparent diffusion coefficients (ADC) using histogram analysis (HA) in predicting disease-free survival (DFS) of cervical cancer after chemo-radiation ther...

Authors: Bo Zhao, Kun Cao, Xiao-Ting Li, Hai-Tao Zhu and Ying-Shi Sun

Expression of the luteinizing hormone receptor (LHR) in ovarian cancer

We investigated the association of LHR expression in epithelial ovarian cancer (OC) with clinical and pathologic characteristics of patients. LHR expression was examined immunohistochemically using tissue micr...

Authors: Shigang Xiong, Paulette Mhawech-Fauceglia, Denice Tsao-Wei, Lynda Roman, Rajesh K. Gaur, Alan L. Epstein and Jacek Pinski