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  1. Content type: Research article

    Triple negative breast cancer (TNBC) is aggressive with limited treatment options upon recurrence. Molecular discordance between primary and metastatic TNBC has been observed, but the degree of biological hete...

    Authors: Zi-Ming Zhao, Susan E. Yost, Katherine E. Hutchinson, Sierra Min Li, Yate-Ching Yuan, Javad Noorbakhsh, Zheng Liu, Charles Warden, Radia M. Johnson, Xiwei Wu, Jeffrey H. Chuang and Yuan Yuan

    Citation: BMC Cancer 2019 19:96

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  2. Content type: Research article

    The efficacy of prophylactic cranial irradiation (PCI) in treating patients with small cell lung cancer (SCLC) has not been clear, and recent randomized studies have demonstrated conflicting results from previ...

    Authors: Xin Yin, Danfang Yan, Miao Qiu, Liming Huang and Sen-Xiang Yan

    Citation: BMC Cancer 2019 19:95

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  3. Content type: Research article

    Stress has been suggested as a promoter of tumor growth and development. Glucocorticoids (GCs) are the main stress hormones and widely prescribed as drugs. However, the effect of GCs on the development and pro...

    Authors: Bo Li, Yan Wang, Lijuan Yin, Gaoxiang Huang, Yi Xu, Jie Su, Liye Ma and Jian Lu

    Citation: BMC Cancer 2019 19:94

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  4. Content type: Research article

    Visceral adipose tissue (VAT) has been identified as the essential fat depot for pathogenetic theories that associateobesity and colon cancer. LINE-1 hypomethylation has been mostly detected in tumor colon tis...

    Authors: Daniel Castellano-Castillo, Sonsoles Morcillo, Ana B. Crujeiras, Lidia Sánchez-Alcoholado, Mercedes Clemente-Postigo, Esperanza Torres, Francisco José Tinahones and Manuel Macias-Gonzalez

    Citation: BMC Cancer 2019 19:93

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  5. Content type: Research article

    To evaluate the clinical outcome in patients with de novo metastatic nasopharyngeal carcinoma (NPC) treated or not treated with locoregional radiotherapy (LRRT) based on plasma Epstein–Barr virus (EBV) DNA lev...

    Authors: Xue-Song Sun, Li-Ting Liu, Sai-Lan Liu, Shan-Shan Guo, Yue-Feng Wen, Hao-Jun Xie, Qing-Nan Tang, Yu-Jing Liang, Xiao-Yun Li, Jin-Jie Yan, Jun Ma, Qiu-Yan Chen, Lin-Quan Tang and Hai-Qiang Mai

    Citation: BMC Cancer 2019 19:92

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  6. Content type: Research article

    Epidemiological research on small cell lung cancer (SCLC) is limited and based on cancer registry data. We evaluated the feasibility and validity of using primary care electronic health records (The Health Imp...

    Authors: Lucía Cea Soriano, Jihong Zong and Luis A. García Rodríguez

    Citation: BMC Cancer 2019 19:91

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  7. Content type: Research article

    The decision making process for axillary dissection has changed in recent years for patients with early breast cancer and positive sentinel lymph nodes (LN). The question now arises, what is the optimal surgic...

    Authors: Florian Ebner, Achim Wöckel, Lukas Schwentner, Maria Blettner, Wolfgang Janni, Rolf Kreienberg and Manfred Wischnewsky

    Citation: BMC Cancer 2019 19:90

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  8. Content type: Study protocol

    Anxiety is a common concern of cancer survivors during the transition from active cancer treatment to cancer survivorship (the re-entry phase). This paper presents the study protocol for a novel group-based be...

    Authors: Joanna J. Arch, Jill L. Mitchell, Sarah R. Genung, Robert Fisher, David J. Andorsky and Annette L. Stanton

    Citation: BMC Cancer 2019 19:89

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  9. Content type: Research article

    The “EMERGE” study, aimed to capture real-life management patterns and outcomes in metastatic breast cancer (MBC) in Greece, also accounting for hormone (HR) and human epidermal growth factor receptor 2 (HER2)...

    Authors: Athanasios Kotsakis, Alexandros Ardavanis, Georgios Koumakis, Epameinondas Samantas, Amanta Psyrri and Christos Papadimitriou

    Citation: BMC Cancer 2019 19:88

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  10. Content type: Research article

    Podoplanin (PDPN) is a mucin-type transmembrane glycoprotein specific to the lymphatic system. PDPN expression has been found in various human tumors and is considered to be a marker of cancer. We had previous...

    Authors: Justyna Sikorska, Damian Gaweł, Hanna Domek, Magdalena Rudzińska and Barbara Czarnocka

    Citation: BMC Cancer 2019 19:85

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  11. Content type: Research article

    In this study, we observe the patterns initial palliative treatment for premenopausal patients with HR-positive/HER2-negative MBC and determine if nonadherence to clinical guidelines are associated with worse ...

    Authors: Hee Kyung Kim, Soo-Hyeon Lee, Yu Jin Kim, Song Ee Park, Han Sang Lee, Sung Won Lim, Jang Ho Cho, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im, Jong Han Yu and Yeon Hee Park

    Citation: BMC Cancer 2019 19:84

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  12. Content type: Research article

    Fascin-1, a prominent actin-bundling protein, is found to be upregulated in several human carcinomas. While it is accepted that Fascin-1 expression correlates with poor clinical outcome and decreased survival ...

    Authors: Matthias J. Arlt, Aleksandar Kuzmanov, Jess G. Snedeker, Bruno Fuchs, Unai Silvan and Adam A. Sabile

    Citation: BMC Cancer 2019 19:83

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  13. Content type: Research article

    Cancer is one of the leading causes of morbidity and mortality worldwide. Seventy percent of deaths of cancer occur in low or middle-income countries, where the resources to provide cancer treatment and care a...

    Authors: Thecla W. Kohi, Louise von Essen, Golden M. Masika, Maria Gottvall and Justine Dol

    Citation: BMC Cancer 2019 19:82

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  14. Content type: Research article

    Age-related genetic changes in lymphocyte subsets are not currently well documented. BACH2 is a transcription factor that plays an important role in immune-mediated homeostasis by tightly regulating PRDM1 expr...

    Authors: Vu Luan Dang Chi, Soizic Garaud, Pushpamali De Silva, Vincent Thibaud, Basile Stamatopoulos, Mimoune Berehad, Chunyan Gu-Trantien, Mohammad Krayem, Hugues Duvillier, Jean-Nicolas Lodewyckx, Karen Willard-Gallo, Catherine Sibille and Dominique Bron

    Citation: BMC Cancer 2019 19:81

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  15. Content type: Research article

    Pathological stage is considered as the best prognosis indicator for gastric cancer. With the increasing use of neoadjuvant chemotherapy (NACT), the latest TNM staging included a new pathological stage of ypTN...

    Authors: Ziyu Li, Yinkui Wang, Xiangji Ying, Fei Shan, Zhouqiao Wu, Lianhai Zhang, Shuangxi Li, Yongning Jia, Hui Ren and Jiafu Ji

    Citation: BMC Cancer 2019 19:80

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  16. Content type: Research article

    BRK is, a non-receptor tyrosine kinase, overexpressed in approximately 85% of human invasive ductal breast tumors. It is not clear whether BRK expression correlates with breast cancer subtypes, or the expressi...

    Authors: Sayem Miah, Edward Bagu, Raghuveera Goel, Yetunde Ogunbolude, Chenlu Dai, Alison Ward, Frederick S. Vizeacoumar, Gerald Davies, Franco J. Vizeacoumar, Deborah Anderson and Kiven Erique Lukong

    Citation: BMC Cancer 2019 19:78

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  17. Content type: Research article

    Synthetic indolyl- pyridinyl- propenones (IPPs) induce methuosis, a form of non-apoptotic cell death, in glioblastoma and other cancer cell lines. Methuosis is characterized by accumulation of cytoplasmic vacu...

    Authors: Zehui Li, Nneka E. Mbah, Jean H. Overmeyer, Jeffrey G. Sarver, Sage George, Christopher J. Trabbic, Paul W. Erhardt and William A. Maltese

    Citation: BMC Cancer 2019 19:77

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  18. Content type: Research article

    Invasive micropapillary carcinoma (IMPC) of the breast is characterized by its unique morphology and frequent nodal metastasis. However, the mechanism for development of this unique subtype has not been clearl...

    Authors: Naoki Kanomata, Junichi Kurebayashi, Yoshikazu Koike, Rin Yamaguchi and Takuya Moriya

    Citation: BMC Cancer 2019 19:76

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  19. Content type: Correction

    Following publication of the original article [1], we have been notified that one of the author names was listed incorrectly.

    Authors: Amy A. Kirkham, D. Ian Paterson, Carla M. Prado, John R. Mackey, Kerry S. Courneya, Edith Pituskin and Richard B. Thompson

    Citation: BMC Cancer 2019 19:75

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    The original article was published in BMC Cancer 2018 18:864

  20. Content type: Research article

    Cancer is a life-threatening disease that causes every fourth death. It is often hard to determine the time point of progression. Therefore, biomarkers for cancer entities that indicate disease progression or ...

    Authors: Lisa Traeger, Ines Ellermann, Helene Wiethoff, Janina Ihbe, Inka Gallitz, Maria Eveslage, Rudolf Moritz, Edwin Herrmann, Andres Jan Schrader and Andrea U. Steinbicker

    Citation: BMC Cancer 2019 19:74

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  21. Content type: Research article

    Several previous studies have confirmed that thrombocytosis was related to reduced survival in many solid tumors. However, the prognostic significance of thrombocytosis in endometrial carcinoma (EC) was still ...

    Authors: Dan Nie, E. Yang and Zhengyu Li

    Citation: BMC Cancer 2019 19:73

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  22. Content type: Research article

    Cholangiocarcinoma (CCA) may arise in the intra- or extrahepatic biliary tract and is associated with a poor prognosis. Despite recent advances, to date there is still no established targeted therapeutic appro...

    Authors: Mark Kriegsmann, Stephanie Roessler, Katharina Kriegsmann, Marcus Renner, Rémi Longuespée, Thomas Albrecht, Moritz Loeffler, Stephan Singer, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil, Bruno Köhler, Christoph Springfeld, Christian Rupp, Karl Heinz Weiss and Benjamin Goeppert

    Citation: BMC Cancer 2019 19:72

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  23. Content type: Research article

    The aim of this study was to evaluate the prognostic potential of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1) tumor tissue levels and examine the association b...

    Authors: Marko Jevrić, Ivana Z. Matić, Ana Krivokuća, Marija Đorđić Crnogorac, Irina Besu, Ana Damjanović, Mirjana Branković-Magić, Zorka Milovanović, Dušica Gavrilović, Snezana Susnjar, Darija Kisić Tepavčević and Tatjana Stanojković

    Citation: BMC Cancer 2019 19:71

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  24. Content type: Research article

    Neoadjuvant chemotherapy is effective in improving survival of resectable NSCLC. Based on findings in the adjuvant and metastatic setting, FDG positron emission tomography (PET) scans may offer early prognosti...

    Authors: Perrin E. Romine, Renato G. Martins, Keith D. Eaton, Douglas E. Wood, Fatemeh Behnia, Bernardo H. L. Goulart, Michael S. Mulligan, Sarah G. Wallace, Elizabeth Kell, Julie E. Bauman, Shilpen A. Patel and Hubert J. Vesselle

    Citation: BMC Cancer 2019 19:70

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  25. Content type: Research article

    Diffuse gastric cancer (DGC) is associated with the reduction or absence of the expression of the cell adhesion protein E-cadherin (encoded by the CDH1 gene). Molecular characteristics are less well described for...

    Authors: Andrea Rebeca Bustos-Carpinteyro, Carla Oliveira, Abel Sousa, Patricia Oliveira, Hugo Pinheiro, Joana Carvalho, María Teresa Magaña-Torres, María Guadalupe Flores-Miramontes, Adriana Aguilar-Lemarroy, Luis Felipe Jave-Suárez, Jorge Peregrina-Sandoval, José Alfonso Cruz-Ramos and Josefina Yoaly Sánchez-López

    Citation: BMC Cancer 2019 19:69

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  26. Content type: Study protocol

    The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway has previously been demonstrated in metastatic head and neck squamous cell carcinoma (HNSCC). Stereotactic Body Radiotherapy (SBRT) aims at ablati...

    Authors: Houda Bahig, Francine Aubin, John Stagg, Olguta Gologan, Olivier Ballivy, Eric Bissada, Felix-Phuc Nguyen-Tan, Denis Soulières, Louis Guertin, Edith Filion, Apostolos Christopoulos, Louise Lambert, Mustapha Tehfe, Tareck Ayad, Danielle Charpentier, Rahima Jamal…

    Citation: BMC Cancer 2019 19:68

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  27. Content type: Research article

    Precise diagnosis of the tissue origin for metastatic cancer of unknown primary (CUP) is essential for deciding the treatment scheme to improve patients’ prognoses, since the treatment for the metastases is th...

    Authors: Mengyao Li, Hongdong Li, Guini Hong, Zhongjie Tang, Guanghao Liu, Xiaofang Lin, Mingzhang Lin, Lishuang Qi and Zheng Guo

    Citation: BMC Cancer 2019 19:67

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  28. Content type: Research article

    Lanreotide depot/autogel antitumor activity in intestinal/pancreatic neuroendocrine tumors (NETs) was demonstrated in the phase-3 CLARINET study (NCT00353496), based on significantly prolonged progression-free...

    Authors: Clarisse Dromain, Marianne E. Pavel, Philippe Ruszniewski, Alison Langley, Christine Massien, Eric Baudin and Martyn E. Caplin

    Citation: BMC Cancer 2019 19:66

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  29. Content type: Research article

    Clear cell renal cell carcinoma (ccRCC) is the most common subtype among renal cancer and is associated with poor prognosis if metastasized. Up to one third of patients with local disease at diagnosis will dev...

    Authors: Emma Andersson Evelönn, Mattias Landfors, Zahra Haider, Linda Köhn, Börje Ljungberg, Göran Roos and Sofie Degerman

    Citation: BMC Cancer 2019 19:65

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  30. Content type: Research article

    Radiotherapy is an indispensable treatment modality in head and neck cancer (HNC), while radioresistance is the major cause of treatment failure. The aim of this study is to identify a prognostic molecular sig...

    Authors: Guo-Rung You, Ann-Joy Cheng, Li-Yu Lee, Yu-Chen Huang, Hsuan Liu, Yin-Ju Chen and Joseph T. Chang

    Citation: BMC Cancer 2019 19:64

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  31. Content type: Research article

    Medical oncology outpatients are a group for whom advance care planning (ACP) activities are particularly relevant. Patient views can help prioritise areas for improving end of life communication. The study ai...

    Authors: Amy Waller, Heidi Turon, Jamie Bryant, Alison Zucca, Tiffany-Jane Evans and Rob Sanson-Fisher

    Citation: BMC Cancer 2019 19:63

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  32. Content type: Research article

    Osteosarcoma is the most prevalent primary bone malignancy in children and young adults. These tumors are highly metastatic, leading to poor outcome. We previously demonstrated that Cysteine-rich protein 61 (C...

    Authors: Nadia Habel, Bojana Stefanovska, Dimitri Carène, Ana Patiño-Garcia, Fernando Lecanda and Olivia Fromigué

    Citation: BMC Cancer 2019 19:62

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  33. Content type: Research article

    Breast cancer is currently the most common neoplasm diagnosed in women globally. There is a growing body of evidence to suggest that human papillomavirus (HPV) infection may play a key role in invasiveness of ...

    Authors: Niloofar Khodabandehlou, Shayan Mostafaei, Ashkan Etemadi, Amir Ghasemi, Mehrdad Payandeh, Shima Hadifar, Amir Hossein Norooznezhad, Anoshirvan Kazemnejad and Mohsen Moghoofei

    Citation: BMC Cancer 2019 19:61

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  34. Content type: Research article

    With the recent introduction of novel treatment options, real-world data from patients with metastatic castration-resistant prostate cancer (mCRPC) are required to better understand the impact on routine clini...

    Authors: Martin Boegemann, Sara Khaksar, Guillaume Bera, Alison Birtle, Catherine Dopchie, Louis-Marie Dourthe, Els Everaert, Martin Hatzinger, Dirko Hercher, Werner Hilgers, Geoffrey Matus, Laura Garcia Alvarez, Laurent Antoni, Martin Lukac, Geneviève Pissart, Paul Robinson…

    Citation: BMC Cancer 2019 19:60

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  35. Content type: Research article

    For successful autologous stem cell transplantation, the collection of a sufficient number of hematopoietic stem cells after induction therapy is essential for transplant candidates with multiple myeloma (MM).

    Authors: Ga-Young Song, Sung-Hoon Jung, Seo-Yeon Ahn, Seung-Yeon Jung, Deok-Hwan Yang, Jae-Sook Ahn, Hyeoung-Joon Kim and Je-Jung Lee

    Citation: BMC Cancer 2019 19:59

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  36. Content type: Study protocol

    The most important goal for survival benefit of advanced stage ovarian cancer is to surgically remove all visible tumour, because complete cytoreductive surgery (CCS) has been shown to be associated with prolo...

    Authors: G. M. Nieuwenhuyzen-de Boer, W. Hofhuis, N. Reesink-Peters, P. C. Ewing-Graham, I. G. Schoots, J. J. Beltman, J. M. J. Piek, A. Baalbergen, G. S. Kooi, A. van Haaften, H. van Huisseling, L. Haans, M. Dorman and H. J. van Beekhuizen

    Citation: BMC Cancer 2019 19:58

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  37. Content type: Correction

    Following publication of the original article [1], the authors notified us that the Additional File 1 contains reviewer comments instead of the Supplementary tables.

    Authors: Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen and Anne Kallioniemi

    Citation: BMC Cancer 2019 19:57

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    The original article was published in BMC Cancer 2018 18:325

  38. Content type: Research article

    Overall survival is the true endpoint for most randomized controlled trials (RCTs) of malignant tumors, whereas progression-free survival (PFS) is considered the most reliable surrogate endpoint for overall su...

    Authors: Kazuhiro Tanaka, Masanori Kawano, Tatsuya Iwasaki, Ichiro Itonaga and Hiroshi Tsumura

    Citation: BMC Cancer 2019 19:56

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  39. Content type: Research article

    To date, the cornerstone of treatment in patients with advanced or metastatic cholangiocarcinoma (CCA) is systemic chemotherapy based on a combination of gemcitabine and a platinum derivative. Other therapeuti...

    Authors: Markus Moehler, Annett Maderer, Anne Ehrlich, Friedrich Foerster, Arno Schad, Tanja Nickolay, Christian Ruckes, Arndt Weinmann, Visvakanth Sivanathan, Jens U. Marquardt, Peter Robert Galle, Marcus Woerns and Thomas Thomaidis

    Citation: BMC Cancer 2019 19:55

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  40. Content type: Research article

    A sizeable body of evidence suggests that statins can cease breast cancer progression and prevent breast cancer recurrence. The latest studies have, however, not been supportive of such clinically beneficial e...

    Authors: Signe Borgquist, Per Broberg, Jasaman Tojjar and Håkan Olsson

    Citation: BMC Cancer 2019 19:54

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  41. Content type: Case report

    Cancers of unknown primary origin (CUPs) are reported to be the 3-4th most common causes of cancer death. Recent years have seen advances in mutational analysis and genomics profiling. These advances could imp...

    Authors: Masanobu Abe, Kousuke Watanabe, Aya Shinozaki-Ushiku, Tetsuo Ushiku, Takahiro Abe, Yuko Fujihara, Yosuke Amano, Liang Zong, Cheng-Ping Wang, Emi Kubo, Ryoko Inaki, Naoya Kinoshita, Satoshi Yamashita, Daiya Takai, Toshikazu Ushijima, Takahide Nagase…

    Citation: BMC Cancer 2019 19:52

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  42. Content type: Case report

    Philadelphia (Ph) chromosome results from the reciprocal translocation t(9;22)(q34.1;q11.2) and is diagnostic for chronic myeloid leukemia (CML). However, this translocation is also found in acute lymphoid leu...

    Authors: Monica Piedimonte, Tiziana Ottone, Valentina Alfonso, Antonella Ferrari, Esmeralda Conte, Mariadomenica Divona, Maria Paola Bianchi, Maria Rosaria Ricciardi, Simone Mirabilii, Roberto Licchetta, Alessia Campagna, Laura Cicconi, Giulia Galassi, Sabrina Pelliccia, Annapaola Leporace, Francesco Lo Coco…

    Citation: BMC Cancer 2019 19:50

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  43. Content type: Research article

    Although, outer membrane protein OipA of Helicobacter pylori has been associated with gastric mucosal damage and gastroduodenal diseases, studies evaluating gastric cancer patients are scarce. We investigated whe...

    Authors: Lúcia Libanez Bessa Campelo Braga, Maria Helane Rocha Batista, Orleâncio Gomes Ripardo de Azevedo, Kassiane Cristine da Silva Costa, Adriana Dias Gomes, Gifone Aguiar Rocha and Dulciene Maria Magalhães Queiroz

    Citation: BMC Cancer 2019 19:48

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  44. Content type: Research article

    To date, no single colorectal cancer (CRC) screening strategy has been determined to be applicable worldwide. In China, a CRC screening protocol that combines double fecal immunochemical tests (FITs) and a hig...

    Authors: Shan-Rong Cai, Yan-Qin Huang, Su-Zhan Zhang, Qi-Long Li, Xin Yuan Ma and Shu Zheng

    Citation: BMC Cancer 2019 19:47

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  45. Content type: Research article

    Transitional cell carcinoma (TCC) accounts for around 95% of bladder cancers and is the 4th most common cancer among men and the tenth most common in women, in the US. There is a constant need to clarify curre...

    Authors: Muneer J. Al-Husseini, Ahmad Kunbaz, Anas M. Saad, João Vasco Santos, Sami Salahia, Marium Iqbal and Fares Alahdab

    Citation: BMC Cancer 2019 19:46

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  46. Content type: Research article

    Poly (ADP-ribose) polymerase inhibitors (PARPi) have become the first targeted therapies available in the treatment of patients with high-grade serous ovarian cancer (HGSOC). We recently described a significan...

    Authors: Tahira Baloch, Vanessa M. López-Ozuna, Qiong Wang, Emad Matanis, Roy Kessous, Liron Kogan, Amber Yasmeen and Walter H. Gotlieb

    Citation: BMC Cancer 2019 19:44

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