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  1. The survival rates of advanced cancer patients remain low despite clinical therapy advancements. However, physical activity showed promising effects in improving cancer outcomes. This review aimed to systemati...

    Authors: Naomi Takemura, Siu Ling Chan, Robert Smith, Denise Shuk Ting Cheung and Chia-Chin Lin

    Citation: BMC Cancer 2021 21:242

    Content type: Research article

    Published on:

  2. Genetic alterations have been proven to be the promising biomarkers for ICI response. However, sex biases in genetic alterations have been often ignored in the field of immunotherapy, which might specially inf...

    Authors: You Ge, Feiran Wei, Guoping Du, Gaoqiang Fei, Wei Li, Xiaoshan Li, Jinjin Chu and Pingmin Wei

    Citation: BMC Cancer 2021 21:240

    Content type: Research article

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  3. Cancer-associated fibroblasts (CAFs) are some of the most abundant components of the tumour microenvironment. A recent study suggested that in some cancers, CAFs express programmed death ligand 1 (PD-L1), whic...

    Authors: Katsuhiro Yoshikawa, Mitsuaki Ishida, Hirotsugu Yanai, Koji Tsuta, Mitsugu Sekimoto and Tomoharu Sugie

    Citation: BMC Cancer 2021 21:239

    Content type: Research article

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  4. Liver metastasis is a significant adverse predictor of overall survival (OS) among breast cancer patients. The purpose of this study was to determine the risk and prognostic factors of breast cancer with liver...

    Authors: Lei Ji, Lei Cheng, Xiuzhi Zhu, Yu Gao, Lei Fan and Zhonghua Wang

    Citation: BMC Cancer 2021 21:238

    Content type: Research article

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  5. Chemotherapy-induced peripheral neuropathy (CIPN) negatively affects physical function and chemotherapy dosing, yet, clinicians infrequently document CIPN assessment and/or adhere to evidence-based CIPN manage...

    Authors: Robert Knoerl, Emanuele Mazzola, Fangxin Hong, Elahe Salehi, Nadine McCleary, Jennifer Ligibel, Kaitlen Reyes and Donna L. Berry

    Citation: BMC Cancer 2021 21:236

    Content type: Research article

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  6. Recent studies have shown that mixed predominantly differentiated-type (MD) early gastric cancer (EGC) might have more malignant potential than pure differentiated-type (PD) EGC. However, no study has analyzed...

    Authors: Yutaka Okagawa, Tetsuya Sumiyoshi, Hitoshi Kondo, Yusuke Tomita, Takeshi Uozumi, Reiichi Iida, Hiroya Sakano, Kaho Tokuchi, Takashi Jin, Masahiro Yoshida, Akira Sakurada, Ryoji Fujii, Takeyoshi Minagawa, Kohtaro Morita, Kei Yane, Hideyuki Ihara…

    Citation: BMC Cancer 2021 21:235

    Content type: Research article

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  7. Neuroendocrine tumours (NETs) arise from hormone-producing or nervous system cells and can develop from anywhere in the body. They have heterogeneous origins from skin to gastrointestinal track and a complicat...

    Authors: Guney Isa Burak, Sonmezler Ozge, Mujde Cem, Buyukdereli Gulgun, Dogruca Yapar Zeynep and Bisgin Atil

    Citation: BMC Cancer 2021 21:234

    Content type: Research article

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  8. It was demonstrated that multifunctional protein APE1 (Apurinic/apyrimidinic endonuclease 1) is closely related to tumor immune microenvironment in a number of investigations, Meanwhile, the abundance of tumor...

    Authors: Yanping Li, Xiaolong Zhao, He Xiao, Bo Yang, Jie Liu, Wen Rao, Xiaoyan Dai, Mengxia Li, Nan Dai, Yuxin Yang and Dong Wang

    Citation: BMC Cancer 2021 21:233

    Content type: Research article

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  9. There is currently a lack of information on full anogenital evaluation of women with a previous history of anogenital neoplasia.

    Authors: Andreia Albuquerque, Michelle A. L. Godfrey, Carmelina Cappello, Francesca Pesola, Julie Bowring, Tamzin Cuming, Anke De Masi, Adam N. Rosenthal, Peter Sasieni and Mayura Nathan

    Citation: BMC Cancer 2021 21:232

    Content type: Research article

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  10. Taking patient centeredness into account is important in healthcare. The European Cancer Consumer Quality Index (ECCQI) is a validated tool for international benchmarking of patient experiences and satisfaction.

    Authors: A. Wind, E. D. Hartman, R. R. J. P. Van Eekeren, R. P. W. F. Wijn, J. Halámková, J. Mattson, S. Siesling and W. H. van Harten

    Citation: BMC Cancer 2021 21:231

    Content type: Research article

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  11. AURA study reported 61% objective response rate and progression-free survival of 9.6 months with osimertinib in patients with EGFR/T790M+ non-small cell lung cancer. Due to lack of real-world data, we proposed...

    Authors: Mariano Provencio, Josefa Terrasa, Pilar Garrido, Rosario García Campelo, Francisco Aparisi, Pilar Diz, David Aguiar, Carlos García-Giron, Julia Hidalgo, Carlos Aguado, Jorge García González, Emilio Esteban, Lorenzo Gómez-Aldavarí, Teresa Moran, Oscar Juan, Luís Enrique Chara…

    Citation: BMC Cancer 2021 21:230

    Content type: Research article

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  12. A recent study found an influence of organized mammography screening programmes (MSPs) on geographical and temporal variation of mastectomy rates. We aimed to quantify the effect on the example of one of the c...

    Authors: Christian Herrmann, Rudolf Morant, Esther Walser, Mohsen Mousavi and Beat Thürlimann

    Citation: BMC Cancer 2021 21:229

    Content type: Research article

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  13. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is an important cancer stem cell marker in gastric cancer. However, no detailed studies are available on LGR5 expression in poorly differentiated...

    Authors: Takehito Ehara, Takeshi Uehara, Tomoyuki Nakajima, Yasuhiro Kinugawa, Shota Kobayashi, Mai Iwaya, Hiroyoshi Ota and Yuji Soejima

    Citation: BMC Cancer 2021 21:228

    Content type: Research article

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  14. Although myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN) – including chronic myeloid leukemia (CML) – and myelodysplastic/myeloproliferative neoplasms (MDS/MPN)...

    Authors: K. A. Mundt, L. D. Dell, P. Boffetta, E. M. Beckett, H. N. Lynch, V. J. Desai, C. K. Lin and W. J. Thompson

    Citation: BMC Cancer 2021 21:227

    Content type: Review

    Published on:

  15. Despite the proportion of elderly breast cancer patients has been consistently increasing, the optimal treatment modalities for this population have not been well explored. We summarized the treatment outcomes...

    Authors: Xu Liu, Dan Zheng, Yanqi Wu, Chuanxu Luo, Yu Fan, Xiaorong Zhong and Hong Zheng

    Citation: BMC Cancer 2021 21:226

    Content type: Research article

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  16. Cervical cancer is preventable and remains a leading cause of avoidable death among women in the world. In a developing country, the knowledge of screening for cervical cancer behavior still very low. However,...

    Authors: Tiruneh Ararsa, Niguse Tadele, Yohannes Ayalew and Debela Gela

    Citation: BMC Cancer 2021 21:224

    Content type: Research article

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  17. Due to recent concerns about the toxicity of trastuzumab emtansine (T-DM1) with stereotactic radiation, we assessed our institutional outcomes treating HER2-positive breast cancer brain metastases (BCBM) with T-D...

    Authors: Matthew N. Mills, Chelsea Walker, Chetna Thawani, Afrin Naz, Nicholas B. Figura, Sergiy Kushchayev, Arnold Etame, Hsiang-Hsuan Michael Yu, Timothy J. Robinson, James Liu, Michael A. Vogelbaum, Peter A. Forsyth, Brian J. Czerniecki, Hatem H. Soliman, Hyo S. Han and Kamran A. Ahmed

    Citation: BMC Cancer 2021 21:223

    Content type: Research article

    Published on:

  18. The role of surgery for the primary tumor in breast cancer patients with bone metastases (BM) remains unclear. The purpose of this study was to determine the impact of surgery for the primary tumor in breast c...

    Authors: Zhangheng Huang, Xin Zhou, Yuexin Tong, Lujian Zhu, Ruhan Zhao and Xiaohui Huang

    Citation: BMC Cancer 2021 21:222

    Content type: Research article

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  19. Predicting the possibility of ipsilateral lateral cervical lymph node metastasis (ipsi-LLNM) was crucial to the operation plan for patients with papillary thyroid carcinoma (PTC). This study aimed to investiga...

    Authors: Ying Zou, Huanlei Zhang, Wenfei Li, Yu Guo, Fang Sun, Yan Shi, Yan Gong, Xiudi Lu, Wei Wang and Shuang Xia

    Citation: BMC Cancer 2021 21:221

    Content type: Research article

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  20. High grade serous ovarian cancer (HGSOC) accounts for nearly 60% of total cases of epithelial ovarian cancer. It is the most aggressive subtype, which shows poor prognosis and low patient survival. For better ...

    Authors: Rachel Topno, Ibha Singh, Manoj Kumar and Pallavi Agarwal

    Citation: BMC Cancer 2021 21:220

    Content type: Research article

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  21. The question whether lymphocyte radiosensitivity is representative of patients’ response to radiotherapy (RT) remains unsolved. We analyzed lymphocyte cytogenetic damage in patients who were homogeneously trea...

    Authors: Leif Hendrik Dröge, Steffen Hennies, Stephan Lorenzen, Lena-Christin Conradi, Henriette Quack, Torsten Liersch, Christian Helms, Miriam Alice Frank, Markus Anton Schirmer, Margret Rave-Fränk, Tim Beißbarth and Hendrik Andreas Wolff

    Citation: BMC Cancer 2021 21:219

    Content type: Research article

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  22. In Korea, where gastric cancer is highly prevalent, biennial endoscopy is recommended among individuals over 40. Even under regular screening, some are still diagnosed at advanced stages. We aimed to identify ...

    Authors: Joo Hyun Lim, Ji Hyun Song, Su Jin Chung, Goh Eun Chung and Joo Sung Kim

    Citation: BMC Cancer 2021 21:218

    Content type: Research article

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  23. Certain sequences of genomic mutations can lead to cancer formation and affect treatment outcomes and drug resistance. We constructed a cancer evolutionary tree using bulk-targeted deep sequencing to explore t...

    Authors: Peng-Chan Lin, Yu-Min Yeh, Ren-Hao Chan, Bo-Wen Lin, Po-Chuan Chen, Chien-Chang Pan and Meng-Ru Shen

    Citation: BMC Cancer 2021 21:217

    Content type: Research article

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  24. HIPEC is an emerging procedure to treat peritoneal metastasis of gastric cancer. Data about HIPEC in locally advanced gastric cancer is scarce. The purpose of this trial is to evaluate the safety and toxicity ...

    Authors: Biao Fan, Zhaode Bu, Ji Zhang, Xianglong Zong, Xin Ji, Tao Fu, Ziyu Jia, Yinan Zhang and Xiaojiang Wu

    Citation: BMC Cancer 2021 21:216

    Content type: Research article

    Published on:

  25. Advances in curative treatment for breast, colorectal, NSCLC and prostate cancer have led to improvements in cancer survival. Cancer treatment and recovery time can vary depending on the recommended modalities...

    Authors: Selina K. Wong, Jeremy Hamm, Aria Shokoohi, Colleen E. McGahan and Cheryl Ho

    Citation: BMC Cancer 2021 21:215

    Content type: Research article

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  26. The outcomes of immediate autologous breast reconstruction (IABR) after partial mastectomy followed by postoperative radiotherapy (RT) in terms of aesthetics, treatment-related complications, and local control...

    Authors: Shu-Ling Zhang, Jun Song, Yan-Ru Wang, Yi-Jia Guo, Jian-Zhu Zhao, Li Sun, Le-Tian Huang, Jie-Tao Ma and Cheng-Bo Han

    Citation: BMC Cancer 2021 21:214

    Content type: Research article

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  27. Lung adenocarcinoma (LUAD) is the most common pathology subtype of lung cancer. In recent years, immunotherapy, targeted therapy and chemotherapeutics conferred a certain curative effects. However, the effect ...

    Authors: Yang Zhai, Bin Zhao, Yuzhen Wang, Lina Li, Jingjin Li, Xu Li, Linhan Chang, Qian Chen and Zijun Liao

    Citation: BMC Cancer 2021 21:213

    Content type: Research article

    Published on:

  28. Information regarding response to past treatments may provide clues concerning the classes of drugs most or least likely to work for a particular metastatic or neoadjuvant early stage breast cancer patient. Ho...

    Authors: Aleksandra K. Olow, Laura van ’t Veer and Denise M. Wolf

    Citation: BMC Cancer 2021 21:212

    Content type: Research article

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  29. Meningiomas are common brain tumours that are usually defined by benign clinical course. However, some meningiomas undergo a malignant transformation and recur within a short time period regardless of their Wo...

    Authors: Waseem Masalha, Karam Daka, Jakob Woerner, Nils Pompe, Stefan Weber, Daniel Delev, Marie T. Krüger, Oliver Schnell, Jürgen Beck, Dieter Henrik Heiland and Juergen Grauvogel

    Citation: BMC Cancer 2021 21:211

    Content type: Research article

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  30. There is evidence to consider that the tumor microenvironment (TME) composition associates with antitumor immune response, and may predict the outcome of various non-Hodgkin lymphoma subtypes. However, in the ...

    Authors: Guilherme Rossi Assis-Mendonça, André Fattori, Rafael Malagoli Rocha, Gustavo Jacob Lourenço, Márcia Torresan Delamain, Suely Nonogaki, Vladmir Cláudio Cordeiro de Lima, Gisele Wally Braga Colleoni, Cármino Antonio de Souza, Fernando Augusto Soares, Carmen Silvia Passos Lima and José Vassallo

    Citation: BMC Cancer 2021 21:209

    Content type: Research article

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  31. Lung cancer is most common among older individuals. However, polypharmacy and comorbidities, which are also more common in older individuals, can limit treatment options. Previous studies suggest that afatinib...

    Authors: Yuji Minegishi, Ou Yamaguchi, Shunichi Sugawara, Shoichi Kuyama, Satoshi Watanabe, Kazuhiro Usui, Masahide Mori, Osamu Hataji, Toshihiro Nukiwa, Satoshi Morita, Kunihiko Kobayashi and Akihiko Gemma

    Citation: BMC Cancer 2021 21:208

    Content type: Research article

    Published on:

  32. Colorectal cancer (CRC) is one of the most common cancers worldwide; it is the fourth leading cause of death in the world and the third in Brazil. Mutations in the APC, DCC, KRAS and TP53 genes have been associat...

    Authors: Aline Simoneti Fonseca, Anelisa Ramão, Matheus Carvalho Bürger, Jorge Estefano Santana de Souza, Dalila Lucíola Zanette, Greice Andreotti de Molfetta, Luiza Ferreira de Araújo, Rafaela de Barros e Lima Bueno, Graziela Moura Aguiar, Jessica Rodrigues Plaça, Cleidson de Pádua Alves, Anemari Ramos Dinarte dos Santos, Daniel Onofre Vidal, Gyl Eanes Barros Silva, Rodrigo Alexandre Panepucci, Fernanda Maris Peria…

    Citation: BMC Cancer 2021 21:207

    Content type: Research article

    Published on:

  33. The adverse reactions (ADRs) of targeted therapy were closely associated with treatment response, clinical outcome, quality of life (QoL) of patients with cancer. However, few studies presented the correlation...

    Authors: Ruofei Du, Xin Wang, Lixia Ma, Leon M. Larcher, Han Tang, Huiyue Zhou, Changying Chen and Tao Wang

    Citation: BMC Cancer 2021 21:206

    Content type: Research article

    Published on:

  34. Oral cancer (OC) is usually diagnosed at advanced clinical stages due to its asymptomatic nature and absence of pathognomonic signs in its early development phase. Delayed diagnosis is one of the major causes ...

    Authors: Mayara Martina Abatti Chiamulera, Caroline Biazzolo Zancan, Aline Pertile Remor, Marcos Freitas Cordeiro, Frederico Omar Gleber-Netto and Antuani Rafael Baptistella

    Citation: BMC Cancer 2021 21:205

    Content type: Research article

    Published on:

  35. With increasing cancer incidence and decreasing cancer mortality, there is a growing need for a valid and culturally adapted tool to measure health-related quality of life in children with cancer. This study v...

    Authors: Hasan Alelayan, Lizhu Liang, Rui Ye, Jiangnan Meng and Xiaoyan Liao

    Citation: BMC Cancer 2021 21:204

    Content type: Research article

    Published on:

  36. The 2018 International Federation of Gynecology and Obstetrics (FIGO) staging guideline for cervical cancer includes stage IIIC recognized by preoperative radiology (IIIC-r) to state there are lymph nodes meta...

    Authors: E Yang, Shuying Huang, Xuting Ran, Yue Huang and Zhengyu Li

    Citation: BMC Cancer 2021 21:203

    Content type: Research article

    Published on:

  37. In recent years, emerging studies have demonstrated critical functions and potential clinical applications of long non-coding RNA (lncRNA) in osteosarcoma. To further validate the prognostic value of multiple ...

    Authors: Wenchao Zhang, Xiaolei Ren, Lin Qi, Chenghao Zhang, Chao Tu and Zhihong Li

    Citation: BMC Cancer 2021 21:202

    Content type: Research article

    Published on:

  38. We assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy.

    Authors: Takeshi Tsutsumi, Kazumasa Komura, Takeshi Hashimoto, Ryu Muraoka, Naoya Satake, Tomohisa Matsunaga, Takuya Tsujino, Yuki Yoshikawa, Tomoaki Takai, Koichiro Minami, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Naokazu Ibuki…

    Citation: BMC Cancer 2021 21:201

    Content type: Research article

    Published on:

  39. Mesothelin is a 40-kDa glycoprotein that is highly overexpressed in various types of cancers, however molecular mechanism of mesothelin has not been well-known. Amatuximab is a chimeric monoclonal IgG1/k antib...

    Authors: Fumihiko Matsuzawa, Hirofumi Kamachi, Tatsuzo Mizukami, Takahiro Einama, Futoshi Kawamata, Yuki Fujii, Moto Fukai, Nozomi Kobayashi, Yutaka Hatanaka and Akinobu Taketomi

    Citation: BMC Cancer 2021 21:200

    Content type: Research article

    Published on:

  40. Breast cancer is one of the leading causes of cancer-related deaths in women, and there is a demand in developing an Asian-based genetic profiling database for breast cancer in improving the treatment response...

    Authors: Chi-Cheng Huang, Yi-Fang Tsai, Chun-Yu Liu, Ta-Chung Chao, Pei-Ju Lien, Yen-Shu Lin, Chin-Jung Feng, Jen-Hwey Chiu, Chih-Yi Hsu and Ling-Ming Tseng

    Citation: BMC Cancer 2021 21:199

    Content type: Research article

    Published on:

  41. The unprecedented efficacy of chimeric antigen receptor T (CAR-T) cell immunotherapy of CD19+ B-cell malignancies has opened a new and useful way for the treatment of malignant tumors. Nonetheless, there are stil...

    Authors: Zhitao Ying, Ting He, Xiaopei Wang, Wen Zheng, Ningjing Lin, Meifeng Tu, Yan Xie, Lingyan Ping, Chen Zhang, Weiping Liu, Lijuan Deng, Meng Wu, Feier Feng, Xin Leng, Tingting Du, Feifei Qi…

    Citation: BMC Cancer 2021 21:198

    Content type: Research article

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  42. Activation of autophagy flux contributed to resistance of breast cancer (BC) cells to current chemotherapeutic drugs, which seriously limited their therapeutic efficacy and facilitated BC recurrence in clinic....

    Authors: Libo Yu, Qingtao Shi, Yan Jin, Zhixin Liu, Jiaxin Li and Wenzhou Sun

    Citation: BMC Cancer 2021 21:195

    Content type: Research article

    Published on:

  43. Multiple common variants identified by genome-wide association studies have shown limited evidence of the risk of breast cancer in Chinese individuals. In this study, we aimed to uncover the relationship betwe...

    Authors: Feng Zhao, Zhixiang Hao, Yanan Zhong, Yinxue Xu, Meng Guo, Bei Zhang, Xiaoxing Yin, Ying Li and Xueyan Zhou

    Citation: BMC Cancer 2021 21:194

    Content type: Research article

    Published on:

  44. KRAS is the most frequently mutated oncogene in cancer, however efforts to develop targeted therapies have been largely unsuccessful. Recently, two small-molecule inhibitors, AMG 510 and MRTX849, have shown promi...

    Authors: Luiz Henrique Araujo, Bianca Mendes Souza, Laura Rabelo Leite, Sabrina A. F. Parma, Natália P. Lopes, Frederico S. V. Malta and Maíra C. M. Freire

    Citation: BMC Cancer 2021 21:193

    Content type: Research article

    Published on:

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