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  1. In patients with bone metastatic castration-resistant prostate cancer (bmCRPC) on systemic treatment, it is difficult to differentiate between continuous rise of prostate specific antigen (PSA) representing pr...

    Authors: Renata Poteska, Kambiz Rahbar, Axel Semjonow, Andres Jan Schrader, Martin Boegemann and Katrin Schlack
    Citation: BMC Cancer 2022 22:375
    Content type: Research Published on:

  2. Studies investigating breast cancer polygenic risk score (PRS) in Chinese women are scarce. The objectives of this study were to develop and validate PRSs that could be used to stratify risk for overall and su...

    Authors: Can Hou, Bin Xu, Yu Hao, Daowen Yang, Huan Song and Jiayuan Li
    Citation: BMC Cancer 2022 22:374
    Content type: Research Published on:

  4. Toxicity during chemoradiotherapy (CRT) in cervical cancer patients might limit the chances of receiving an optimal treatment and to be cured. Few studies have shown relationships between acute side effects an...

    Authors: Annica Holmqvist, Gabriel Lindahl, Rasmus Mikivier and Srinivas Uppungunduri
    Citation: BMC Cancer 2022 22:371
    Content type: Research Published on:

  5. T-cell immunoglobulin mucin-1 (TIM-1) has been reported to be associated with the biological behavior of several malignant tumors; however, it is not clear whether it has a role in cervical cancer (CC).

    Authors: Liuyan Chen, Jilin Qing, Yangyang Xiao, Xiaomei Huang, Yanlin Chi and Zhizhong Chen
    Citation: BMC Cancer 2022 22:370
    Content type: Research article Published on:

  6. The utility of circulating tumour DNA (ctDNA) for longitudinal tumour monitoring in pancreatic ductal adenocarcinoma (PDAC) has not been explored beyond mutations in the KRAS proto-oncogene. Here, we aimed to cha...

    Authors: Lavanya Sivapalan, Graeme J. Thorn, Emanuela Gadaleta, Hemant M. Kocher, Helen Ross-Adams and Claude Chelala
    Citation: BMC Cancer 2022 22:369
    Content type: Research Published on:

  7. This study aimed to evaluate the utility of inflammation-based prognostic scores (IBPS) and systemic immune-inflammation index (SII) in the treatment of oral cancer patients.

    Authors: Kosei Kubota, Ryohei Ito, Norihiko Narita, Yusuke Tanaka, Ken Furudate, Natsumi Akiyama, Chuang Hao Chih, Shotaro Komatsu and Wataru Kobayashi
    Citation: BMC Cancer 2022 22:368
    Content type: Research Published on:

  8. High-grade and recurrent meningiomas are often treatment resistant and pose a therapeutic challenge after surgical and radiation therapy (RT) failure. Temozolomide (TMZ) is a DNA alkylating agent that appears ...

    Authors: Katherine Belanger, Timothy H. Ung, Denise Damek, Kevin O. Lillehei and D. Ryan Ormond
    Citation: BMC Cancer 2022 22:367
    Content type: Research Published on:

  10. N6-methyladenosine (m6A) mRNA modification triggers malignant behaviors of tumor cells and thereby drives malignant progression in gastric cancer (GC). However, data regarding the prognostic values of m6A RNA met...

    Authors: Liangliang Lei, Nannan Li, Pengfei Yuan and Dechun Liu
    Citation: BMC Cancer 2022 22:365
    Content type: Research Published on:

  11. In clinical practice, the effect of durvalumab and radiation pneumonitis (RP) on survival after intensity-modulated radiotherapy (IMRT) is not fully understood. The purpose of this retrospective study was to i...

    Authors: Takaya Yamamoto, Yoko Tsukita, Yu Katagiri, Haruo Matsushita, Rei Umezawa, Yojiro Ishikawa, Noriyoshi Takahashi, Yu Suzuki, Kazuya Takeda, Eisaku Miyauchi, Ryota Saito, Yoshiyuki Katsuta, Noriyuki Kadoya and Keiichi Jingu
    Citation: BMC Cancer 2022 22:364
    Content type: Research Published on:

  12. Radio-chemotherapy with 5-flu orouracil (5-FU) is the standard of care treatment for patients with colorectal cancer, but it is only effective for a third of them. Despite our understanding of the mechanism of...

    Authors: Anaïs Chauvin, Danny Bergeron, Jean Vencic, Dominique Lévesque, Benoit Paquette, Michelle S. Scott and François-Michel Boisvert
    Citation: BMC Cancer 2022 22:363
    Content type: Research Published on:

  14. Tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) may be useful prognostic indicators in endometrial cancer. However, standardized assessment methods and the prognostic roles of the...

    Authors: Takako Kono-Sato, Kosuke Miyai, Yoji Yamagishi, Morikazu Miyamoto, Masashi Takano, Susumu Matsukuma, Kimiya Sato and Hitoshi Tsuda
    Citation: BMC Cancer 2022 22:361
    Content type: Research Published on:

  15. Women with metastatic breast cancer (MBC) report debilitating physical and psychological symptoms, including fatigue, anxiety, and pain, that greatly impact their quality of life. Immersive virtual reality (VR...

    Authors: Lisa M. Reynolds, Alana Cavadino, Stanley Chin, Zoë Little, Amelia Akroyd, Geraldine Tennant, Rosie Dobson, Reuben Broom and Adèle Gautier
    Citation: BMC Cancer 2022 22:360
    Content type: Research Published on:

  16. Additive/adjuvant chemotherapy as concept after local treatment of colorectal metastases has not been proven to be successful by phase III trials. Accordingly, a standard of care to improve relapse rates and l...

    Authors: Nathanael Raschzok, Sebastian Stintzing, Volker Heinemann, Geraldine Rauch, Jens Ricke, Matthias Guckenberger, Annika Kurreck, Annabel H. S. Alig, Arndt Stahler, Lars Bullinger, Moritz Schmelzle, Wenzel Schöning, Georg Lurje, Felix Krenzien, Oliver Haase, Beate Rau…
    Citation: BMC Cancer 2022 22:359
    Content type: Study protocol Published on:

  17. Breast-conserving surgery (BCS) and whole breast radiation therapy (WBRT) are the standard of care for early-stage breast cancer (BC). Based on the observation that most local recurrences occurred near the tum...

    Authors: Maria Alessia Zerella, Mattia Zaffaroni, Giuseppe Ronci, Samantha Dicuonzo, Damaris Patricia Rojas, Anna Morra, Cristiana Fodor, Elena Rondi, Sabrina Vigorito, Francesca Botta, Marta Cremonesi, Cristina Garibaldi, Silvia Penco, Viviana Enrica Galimberti, Mattia Intra, Sara Gandini…
    Citation: BMC Cancer 2022 22:358
    Content type: Study protocol Published on:

  18. Lymph node (LN) status is a key prognostic factor in the decision-making process of different cancer entities, including prostate cancer (PCa). Sectioning and haematoxylin and eosin (H&E) staining technique re...

    Authors: Mercè Cuadras, Jacques Planas, Ana Celma, Lucas Regis, Inés M. de Torres, M. Eugenia Semidey, Enrique Trilla and Juan Morote
    Citation: BMC Cancer 2022 22:357
    Content type: Research Published on:

  19. Colorectal cancer (CRC) incidence in Finland has risen steadily. Given development in cancer treatments in recent decades, disease-specific data on the long-term prognosis of patients may be obsolete. Thus, th...

    Authors: Tobias Olenius, Laura Koskenvuo, Selja Koskensalo, Anna Lepistö and Camilla Böckelman
    Citation: BMC Cancer 2022 22:356
    Content type: Research Published on:

  20. We aimed to investigate response and prognostic factors in patients with human epidermal growth factor receptor 2 (HER2) positive metastatic colorectal cancer (mCRC) and compare the curative effect on patients...

    Authors: Liu Yang, Wenfei Li, Zhihao Lu, Ming Lu, Jun Zhou, Zhi Peng, Xiaotian Zhang, Xicheng Wang, Lin Shen and Jian Li
    Citation: BMC Cancer 2022 22:355
    Content type: Research Published on:

  21. Papillary thyroid carcinoma (PTC) is the most common histological type of thyroid malignancy that tends to metastasize to cervical lymph nodes. In the present study, we aimed to investigate which clinicopathol...

    Authors: Cui Zhang, Baojun Li, Lei Zhang, Fengjiao Chen, Yanhua Zhang and Wen Cheng
    Citation: BMC Cancer 2022 22:354
    Content type: Research Published on:

  22. Depression has been reported to be associated with some types of cancer in observational studies. However, the direction and magnitude of the causal relationships between depression and different types of canc...

    Authors: Guang-Li Zhu, Cheng Xu, Kai-bin Yang, Si-Qi Tang, Ling-Long Tang, Lei Chen, Wen-Fei Li, Yan-Ping Mao and Jun Ma
    Citation: BMC Cancer 2022 22:353
    Content type: Research article Published on:

  24. Recently the role of microRNAs has been explored immensely as novel regulators and potential biomarkers in several cancers. MiR-509-3p is one such miRNA that has been observed to show a mixed expression in dif...

    Authors: Deepak Narayanan Iyer, Dominic Chi-Chung Foo, Oswens Siu-Hung Lo, Timothy Ming-Hun Wan, Xue Li, Ryan Wai-Yan Sin, Roberta Wen-Chi Pang, Wai-Lun Law and Lui Ng
    Citation: BMC Cancer 2022 22:351
    Content type: Research article Published on:

  27. The purpose of this study was to investigate the ability of differential diagnosis of prostate specific antigen decline rate (PSADR) per week, degree of prostatic collapse (DPC) and tissue signal rate of prost...

    Authors: Minxin He, Li Wang, Hong Wang, Fang Liu, Mingrui Li, Tie Chong and Li Xue
    Citation: BMC Cancer 2022 22:348
    Content type: Research Published on:

  29. In women with newly diagnosed ovarian cancer, bevacizumab and poly (ADP-ribose) polymerase inhibitors (PARPi) exhibit improved progression-free survival (PFS) when administered concurrent with chemotherapy and...

    Authors: Young Ju Suh, Banghyun Lee, Kidong Kim, Yujin Jeong, Hwa Yeon Choi, Sung Ook Hwang and Yong Beom Kim
    Citation: BMC Cancer 2022 22:346
    Content type: Research Published on:

  30. Although cigarette smoking is the most significant risk factor for laryngeal cancer, other risk factors might also be associated with the development of laryngeal cancer. We investigated whether underweight an...

    Authors: Oh. Hyeong Lee, Yong-Moon Park, Seung-Hyun Ko, Kyuna Lee, Yeonji Kim, Kyungdo Han and Jung-Hae Cho
    Citation: BMC Cancer 2022 22:345
    Content type: Research Published on:

  31. The incidence and mortality of thyroid cancer (TC) has been steadily rising in the past decades. It is imperative to have a better understanding of the molecular mechanisms underlying TC development and identi...

    Authors: Xiaozhou Zhang, Xiaojian Zhang, Qian Jia, Hongqiang Li, Runsheng Ma, Guang Yang, Fengyan Yin, Nannan Jiang and Detao Yin
    Citation: BMC Cancer 2022 22:344
    Content type: Research Published on:

  32. The analysis of long non-coding RNA (lncRNA) in endometrial cancer is a novel field of science. Although numerous lncRNA sequences have been identified until today, their correlation with endometrial cancer is...

    Authors: Jan Bieńkiewicz, Hanna Romanowicz, Bożena Szymańska, Daria Domańska-Senderowska, Miłosz Wilczyński, Anna Stepowicz, Andrzej Malinowski and Beata Smolarz
    Citation: BMC Cancer 2022 22:343
    Content type: Research Published on:

  33. Platinum-based chemoradiotherapy is the standard treatment for unresectable stage III non-small-cell lung cancer (NSCLC). However, few studies have evaluated the efficacy of subsequent chemotherapy for relapse...

    Authors: Eriko Miyawaki, Hirotsugu Kenmotsu, Yasushi Shintani, Ikuo Sekine, Takehito Shukuya, Koichi Takayama, Akira Inoue, Isamu Okamoto, Katsuyuki Kiura, Kazuhisa Takahashi, Nobuyuki Yamamoto, Tomoya Kawaguchi, Etsuo Miyaoka, Ichiro Yoshino and Hiroshi Date
    Citation: BMC Cancer 2022 22:342
    Content type: Research Published on:

  34. Since colon cancer stem cells (CSCs) play an important role in chemoresistance and in tumor recurrence and metastasis, targeting of CSCs has emerged as a sophisticated strategy for cancer therapy. α-mangostin ...

    Authors: Min Kyoung Jo, Chang Mo Moon, Eun Ju Kim, Ji-Hee Kwon, Xiang Fei, Seong-Eun Kim, Sung-Ae Jung, Minsuk Kim, Yeung-Chul Mun, Young-Ho Ahn, Seung-Yong Seo and Tae Il Kim
    Citation: BMC Cancer 2022 22:341
    Content type: Research Published on:

  35. Childhood cancer survivors lacking awareness on their potential risks of late effects often fail to seek adequate follow-up care. Patient education matching their preference is of great importance to improve t...

    Authors: Daisuke Masumoto, Etsuko Nakagami-Yamaguchi, Misako Nambu, Miho Maeda, Hideko Uryu, Akira Hayakawa, Zayar Linn, Satoshi Okamura, Kosuke Kurihara, Kentaro Kihira, Takao Deguchi and Hiroki Hori
    Citation: BMC Cancer 2022 22:340
    Content type: Research Published on:

  37. An accurate knowledge of the relocation of prostate neoplasms during biopsy is of great importance to reduce the number of false negative results. Prostate neoplasms are visible in magnetic resonance images (M...

    Authors: Muhammad Qasim, Dolors Puigjaner, Joan Herrero, Josep M. López, Carme Olivé, Gerard Fortuny and Josep Garcia-Bennett
    Citation: BMC Cancer 2022 22:338
    Content type: Research Published on:

  38. Failure rate in randomized controlled trials (RCTs) is > 50%, includes safety-problems, underpowered statistics, lack of efficacy, lack of funding or insufficient patient recruitment and is even more pronounce...

    Authors: S. K. B. Spohn, S. Adebahr, M. Huber, C. Jenkner, R. Wiehle, B. Nagavci, C. Schmucker, E. G. Carl, R. C. Chen, W. A. Weber, M. Mix, A. Rühle, T. Sprave, N. H. Nicolay, C. Gratzke, M. Benndorf…
    Citation: BMC Cancer 2022 22:337
    Content type: Research Published on:

  39. Brain metastasis (BM) of colorectal cancer is a disease with a poor prognosis of only a few months survival. However, it is difficult to estimate the individual prognosis of each patient due to the lack of def...

    Authors: Caroline Sander, Clara Frydrychowicz, Gordian Prasse, Sabine Taubenheim, Felix Arlt, Jürgen Meixensberger and Michael Karl Fehrenbach
    Citation: BMC Cancer 2022 22:336
    Content type: Research Published on:

  40. The purpose of this study was to explore the efficacy and safety of transarterial chemoembolization (TACE) combined with apatinib and camrelizumab (TACE + AC) for unresectable hepatocellular carcinoma (HCC), a...

    Authors: Shuguang Ju, Chen Zhou, Junwen Hu, Yingliang Wang, Chaoyang Wang, Jiacheng Liu, Chongtu Yang, Songjiang Huang, Tongqiang Li, Yang Chen, Yaowei Bai, Wei Yao and Bin Xiong
    Citation: BMC Cancer 2022 22:335
    Content type: Research Published on:

  41. Normal human tissues do not express glycans terminating with the sialic acid N-glycolylneuraminic acid (Neu5Gc), yet Neu5Gc-containing glycans have been consistently found in human tumor tissues, cells and secret...

    Authors: Lucy K. Shewell, Christopher J. Day, Jamie R. Kutasovic, Jodie L. Abrahams, Jing Wang, Jessica Poole, Colleen Niland, Kaltin Ferguson, Jodi M. Saunus, Sunil R. Lakhani, Mark von Itzstein, James C. Paton, Adrienne W. Paton and Michael P. Jennings
    Citation: BMC Cancer 2022 22:334
    Content type: Research article Published on:

  42. Esophageal squamous cell carcinoma (ESCC) survival is mainly reported at the time of treatment. Conditional survival is another prognostic tool to evaluate ESCC patients who has survived more than one year sin...

    Authors: Mingqiang Liang, Jiazhou Xiao, Maohui Chen, Bin Zheng and Chun Chen
    Citation: BMC Cancer 2022 22:333
    Content type: Research article Published on:

  43. Tyrosine kinase inhibitors (TKIs) as first-line therapy for Chronic Myeloid Leukemia (CML) show a high success rate. However, a low number of patients with long-term treatment-free remission (TFR) were observe...

    Authors: Aliza Mohd Yacob, Nor Asiah Muhamad, Kian Meng Chang, Hamidah Akmal Hisham, Yuslina Mat Yusoff and Latifah Ibrahim
    Citation: BMC Cancer 2022 22:332
    Content type: Research article Published on:

  44. The Laparoscopic Approach to Cervical Cancer trial and Surveillance, Epidemiology, and End Results program database study demonstrated that minimally invasive radical hysterectomy was inferior to abdominal rad...

    Authors: Soo Jin Park, Tae Wook Kong, Taehun Kim, Maria Lee, Chel Hun Choi, Seung-Hyuk Shim, Ga Won Yim, Seungmee Lee, Eun Ji Lee, Myong Cheol Lim, Suk-Joon Chang, Sung Jong Lee, San Hui Lee, Taejong Song, Yoo-Young Lee, Hee Seung Kim…
    Citation: BMC Cancer 2022 22:331
    Content type: Study protocol Published on:

  45. The epidemiological investigation of different cancer types in the global population has reported a decreased risk of bladder cancer (BLCA) in Parkinson’s diseases (PD). SNCA a critical gene in PD pathology have ...

    Authors: Zhengcun Wu, Chengxing Xia, Chao Zhang, Delin Yang and Kaili Ma
    Citation: BMC Cancer 2022 22:330
    Content type: Research Published on:

  46. We aimed to evaluate the prognosis and adjuvant chemotherapy (ACT) in intrahepatic cholangiocarcinoma (ICC) patients with different etiology after radical resection.

    Authors: Qi Li, Chen Chen, Jingbo Su, Yinghe Qiu, Hong Wu, Tianqiang Song, Xianhai Mao, Yu He, Zhangjun Cheng, Jingdong Li, Wenlong Zhai, Dong Zhang, Zhimin Geng and Zhaohui Tang
    Citation: BMC Cancer 2022 22:329
    Content type: Research Published on:

  47. Postoperative adjuvant cisplatin-based chemotherapy had been the standard care in patients with completely resected high-risk stage IB to IIIA non-small cell lung cancer (NSCLC) for decades. However, the survi...

    Authors: Pengfei Zhao, Hongchao Zhen, Hong Zhao, Lei Zhao and Bangwei Cao
    Citation: BMC Cancer 2022 22:328
    Content type: Research Published on:

  48. The skeletal muscle index (SMI), which is calculated as the ratio of skeletal muscle area at the third lumbar vertebral level divided by height squared, has been considered a prognostic factor in patients with...

    Authors: Masatsugu Amitani, Takaaki Oba, Nami Kiyosawa, Hiroki Morikawa, Tatsunori Chino, Ai Soma, Tadafumi Shimizu, Koichi Ohno, Mayu Ono, Tokiko Ito, Toshiharu Kanai, Kazuma Maeno and Ken-ichi Ito
    Citation: BMC Cancer 2022 22:327
    Content type: Research Published on:

  49. This study aimed to compare the survival outcomes between squamous cell carcinoma (SCC) and adenocarcinoma/adenosquamous carcinoma (AC/ASC) of the cervix after radical radiotherapy and chemotherapy.

    Authors: Ping Liu, Mei Ji, Yanxiang Kong, Zhifeng Huo, Qiubo Lv, Qinghuang Xie, Danbo Wang, Biliang Chen, Hailin Wang, Zhumei Cui, Qianqing Wang, Xiaonong Bin, Jinghe Lang and Chunlin Chen
    Citation: BMC Cancer 2022 22:326
    Content type: Research Published on:

  50. This article has been retracted. Please see the Retraction Notice for more detail: https://​doi.​org/​10.​1186/​1471-2407-14-243.

    Authors: Damao Huang, Yuejin Li, Na Liu, Zhenlin Zhang, Zhengke Peng, Chaojun Duan, Xiaowei Tang, Gongjun Tan, Guangrong Yan and Faqing Tang
    Citation: BMC Cancer 2022 22:324
    Content type: Retraction Note Published on:

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