Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA Cancer J Clin. 2021;71(1):7–33.
Article
PubMed
Google Scholar
Burdett S, Pignon JP, Tierney J, Tribodet H, Stewart L, Le Pechoux C, Auperin A, Le Chevalier T, Stephens RJ, Arriagada R, et al. Adjuvant chemotherapy for resected early-stage non-small cell lung cancer. Cochrane Database Syst Rev. 2015(3):CD011430.
Goldstraw P, Crowley J, Chansky K, Giroux DJ, Groome PA, Rami-Porta R, Postmus PE, Rusch V, Sobin L, International Association for the Study of Lung Cancer International Staging C, et al. The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours. J Thorac Oncol. 2007;2(8):706–14.
Wong ML, McMurry TL, Stukenborg GJ, Francescatti AB, Amato-Martz C, Schumacher JR, et al. Impact of age and comorbidity on treatment of non-small cell lung cancer recurrence following complete resection: a nationally representative cohort study. Lung Cancer. 2016;102:108–17.
Article
PubMed
Google Scholar
Sugimura H, Nichols FC, Yang P, Allen MS, Cassivi SD, Deschamps C, et al. Survival after recurrent nonsmall-cell lung cancer after complete pulmonary resection. Ann Thorac Surg. 2007;83(2):409–17 discussioin 417–408.
Article
PubMed
Google Scholar
Bradbury P, Sivajohanathan D, Chan A, Kulkarni S, Ung Y, Ellis PM. Postoperative adjuvant systemic therapy in completely resected non-small-cell lung Cancer: a systematic review. Clin Lung Cancer. 2017;18(3):259–273 e258.
Article
PubMed
Google Scholar
Pignon JP, Tribodet H, Scagliotti GV, Douillard JY, Shepherd FA, Stephens RJ, et al. Lung adjuvant cisplatin evaluation: a pooled analysis by the LACE collaborative group. J Clin Oncol. 2008;26(21):3552–9.
Article
PubMed
Google Scholar
Remon J, Lianes P, Martinez S, Velasco M, Querol R, Zanui M. Adjuvant treatment in resected non-small cell lung cancer: current and future issues. Crit Rev Oncol Hematol. 2013;88(2):375–86.
Article
PubMed
Google Scholar
Kris MG, Gaspar LE, Chaft JE, Kennedy EB, Azzoli CG, Ellis PM, et al. Adjuvant systemic therapy and adjuvant radiation therapy for stage I to IIIA completely resected non-small-cell lung cancers: American Society of Clinical Oncology/Cancer Care Ontario clinical practice guideline update. J Clin Oncol. 2017;35(25):2960–74.
Article
PubMed
Google Scholar
Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, et al. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 2012;13(3):239–46.
Article
CAS
PubMed
Google Scholar
Brown T, Boland A, Bagust A, Oyee J, Hockenhull J, Dundar Y, et al. Gefitinib for the first-line treatment of locally advanced or metastatic non-small cell lung cancer. Health Technol Assess. 2010;14(Suppl. 2):71–9.
Article
CAS
PubMed
Google Scholar
Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, et al. Osimertinib in untreated EGFR-mutated advanced non-small-cell lung Cancer. N Engl J Med. 2018;378(2):113–25.
Article
CAS
PubMed
Google Scholar
Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, et al. Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 2010;362(25):2380–8.
Article
CAS
PubMed
Google Scholar
Wu YL, Zhou C, Liam CK, Wu G, Liu X, Zhong Z, et al. First-line erlotinib versus gemcitabine/cisplatin in patients with advanced EGFR mutation-positive non-small-cell lung cancer: analyses from the phase III, randomized, open-label. ENSURE study Ann Oncol. 2015;26(9):1883–9.
Article
PubMed
Google Scholar
Xie H, Wang H, Xu L, Li M, Peng Y, Cai X, et al. Gefitinib versus adjuvant chemotherapy in patients with stage II-IIIA non-small-cell lung Cancer harboring positive EGFR mutations: a single-center retrospective study. Clin Lung Cancer. 2018;19(6):484–92.
Article
CAS
PubMed
Google Scholar
Pennell NA, Neal JW, Chaft JE, Azzoli CG, Janne PA, Govindan R, et al. SELECT: a phase II trial of adjuvant Erlotinib in patients with resected epidermal growth factor receptor-mutant non-small-cell lung Cancer. J Clin Oncol. 2019;37(2):97–104.
Article
CAS
PubMed
Google Scholar
Goss GD, O'Callaghan C, Lorimer I, Tsao MS, Masters GA, Jett J, et al. Gefitinib versus placebo in completely resected non-small-cell lung cancer: results of the NCIC CTG BR19 study. J Clin Oncol. 2013;31(27):3320–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Li N, Ou W, Ye X, Sun HB, Zhang L, Fang Q, et al. Pemetrexed-carboplatin adjuvant chemotherapy with or without gefitinib in resected stage IIIA-N2 non-small cell lung cancer harbouring EGFR mutations: a randomized, phase II study. Ann Surg Oncol. 2014;21(6):2091–6.
Article
PubMed
Google Scholar
Feng S, Wang Y, Cai K, Wu H, Xiong G, Wang H, et al. Randomized adjuvant chemotherapy of EGFR-mutated non-small cell lung Cancer patients with or without Icotinib consolidation therapy. PLoS One. 2015;10(10):e0140794.
Article
PubMed
PubMed Central
Google Scholar
Kelly K, Altorki NK, Eberhardt WE, O'Brien ME, Spigel DR, Crino L, et al. Adjuvant Erlotinib versus placebo in patients with stage IB-IIIA non-small-cell lung Cancer (RADIANT): a randomized, double-blind. Phase III Trial J Clin Oncol. 2015;33(34):4007–14.
CAS
PubMed
Google Scholar
Yue D, Xu S, Wang Q, Li X, Shen Y, Zhao H, et al. Erlotinib versus vinorelbine plus cisplatin as adjuvant therapy in Chinese patients with stage IIIA EGFR mutation-positive non-small-cell lung cancer (EVAN): a randomised, open-label, phase 2 trial. Lancet Respir Med. 2018;6(11):863–73.
Article
CAS
PubMed
Google Scholar
Zhong WZ, Wang Q, Mao WM, Xu ST, Wu L, Shen Y, et al. Gefitinib versus vinorelbine plus cisplatin as adjuvant treatment for stage II-IIIA (N1-N2) EGFR-mutant NSCLC (ADJUVANT/CTONG1104): a randomised, open-label, phase 3 study. Lancet Oncol. 2018;19(1):139–48.
Article
CAS
PubMed
Google Scholar
Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, et al. Osimertinib in resected EGFR-mutated non-small-cell lung Cancer. N Engl J Med. 2020;383(18):1711–23.
Article
CAS
PubMed
Google Scholar
He J, Su C, Liang W, Xu S, Wu L, Fu X, et al. Icotinib versus chemotherapy as adjuvant treatment for stage II-IIIA EGFR-mutant non-small-cell lung cancer (EVIDENCE): a randomised, open-label, phase 3 trial. Lancet Respir Med. 2021;9(9):1021–9.
Article
CAS
PubMed
Google Scholar
Cheng H, Li XJ, Wang XJ, Chen ZW, Wang RQ, Zhong HC, et al. A meta-analysis of adjuvant EGFR-TKIs for patients with resected non-small cell lung cancer. Lung Cancer. 2019;137:7–13.
Article
PubMed
Google Scholar
Yin Q, Xun X, Yang G, Cui H, Liu H. Efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in the adjuvant setting for patients with resected epidermal growth factor receptor mutant non-small cell lung Cancer: a Meta-analysis with 11 trials. Oncol Res Treat. 2021;44(6):344–53.
Article
CAS
PubMed
Google Scholar
Chen RL, Sun LL, Cao Y, Chen HR, Zhou JX, Gu CY, et al. Adjuvant EGFR-TKIs for patients with resected EGFR-mutant non-small cell lung Cancer: a Meta-analysis of 1,283 patients. Front Oncol. 2021;11:629394.
Article
PubMed
PubMed Central
Google Scholar
Tada H, Mitsudomi T, Misumi T, Sugio K, Tsuboi M, Okamoto I, et al. Randomized phase III study of Gefitinib versus cisplatin plus Vinorelbine for patients with resected stage II-IIIA non-small-cell lung Cancer with EGFR mutation (IMPACT). J Clin Oncol. 2022;40(3):231–41.
Article
CAS
PubMed
Google Scholar
National Comprehensive Cancer Network. NCCN clinical PracticeGuidelines in oncology: non-small cell lung Cancer, version 7. 2021. Available at https://www.nccn.org/guidelines.
Google Scholar
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097.
Article
Google Scholar
Cumpston M, Li T, Page MJ, Chandler J, Welch VA, Higgins JP, et al. Updated guidance for trusted systematic reviews: a new edition of the Cochrane handbook for systematic reviews of interventions. Cochrane Database Syst Rev. 2019;10:ED000142.
PubMed
Google Scholar
Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.
Article
PubMed
PubMed Central
Google Scholar
Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials. 2007;8:16.
Article
PubMed
PubMed Central
Google Scholar
Raphael J, Vincent M, Boldt G, Shah PS, Rodrigues G, Blanchette P. Adjuvant epidermal growth factor receptor tyrosine kinase inhibitors (TKIs) in resected non-small cell lung Cancer (NSCLC): a systematic review and Meta-analysis. Am J Clin Oncol. 2019;42(5):440–5.
Article
CAS
PubMed
Google Scholar
Huang Q, Li J, Sun Y, Wang R, Cheng X, Chen H. Efficacy of EGFR tyrosine kinase inhibitors in the adjuvant treatment for operable non-small cell lung Cancer by a Meta-analysis. Chest. 2016;149(6):1384–92.
Article
PubMed
Google Scholar
Zhong WZ, Wang Q, Mao WM, Xu ST, Wu L, Wei YC, et al. Gefitinib versus Vinorelbine plus cisplatin as adjuvant treatment for stage II-IIIA (N1-N2) EGFR-mutant NSCLC: final overall survival analysis of CTONG1104 phase III trial. J Clin Oncol. 2021;39(7):713–22.
Article
CAS
PubMed
Google Scholar
Cross DA, Ashton SE, Ghiorghiu S, Eberlein C, Nebhan CA, Spitzler PJ, et al. AZD9291, an irreversible EGFR TKI, overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer. Cancer Discov. 2014;4(9):1046–61.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ballard P, Yates JW, Yang Z, Kim DW, Yang JC, Cantarini M, et al. Preclinical comparison of Osimertinib with other EGFR-TKIs in EGFR-mutant NSCLC brain metastases models, and early evidence of clinical brain metastases activity. Clin Cancer Res. 2016;22(20):5130–40.
Article
CAS
PubMed
Google Scholar
Mok TS, Wu YL, Ahn MJ, Garassino MC, Kim HR, Ramalingam SS, et al. Osimertinib or platinum-Pemetrexed in EGFR T790M-positive lung Cancer. N Engl J Med. 2017;376(7):629–40.
Article
CAS
PubMed
Google Scholar
Goss G, Tsai CM, Shepherd FA, Ahn MJ, Bazhenova L, Crino L, et al. CNS response to osimertinib in patients with T790M-positive advanced NSCLC: pooled data from two phase II trials. Ann Oncol. 2018;29(3):687–93.
Article
CAS
PubMed
Google Scholar
Mauguen A, Pignon JP, Burdett S, Domerg C, Fisher D, Paulus R, et al. Surrogate endpoints for overall survival in chemotherapy and radiotherapy trials in operable and locally advanced lung cancer: a re-analysis of meta-analyses of individual patients’ data. Lancet Oncol. 2013;14(7):619–26.
Article
PubMed
PubMed Central
Google Scholar
Gyawali B, West HJ. Lessons from ADAURA on adjuvant Cancer drug trials: evidence, ethics, and economics. J Clin Oncol. 2021;39(3):175–7.
Article
PubMed
Google Scholar
Gristina V, Malapelle U, Galvano A, Pisapia P, Pepe F, Rolfo C, et al. The significance of epidermal growth factor receptor uncommon mutations in non-small cell lung cancer: a systematic review and critical appraisal. Cancer Treat Rev. 2020;85:101994.
Article
CAS
PubMed
Google Scholar
Evans M, O'Sullivan B, Smith M, Hughes F, Mullis T, Trim N, et al. Large-scale EGFR mutation testing in clinical practice: analysis of a series of 18,920 non-small cell lung Cancer cases. Pathol Oncol Res. 2019;25(4):1401–9.
Article
CAS
PubMed
Google Scholar
Passaro A, Leighl N, Blackhall F, Popat S, Kerr K, Ahn MJ, et al. ESMO expert consensus statements on the management of EGFR mutant non-small cell lung Cancer. Ann Oncol. 2022.