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Concomitant Temozolomide plus radiotherapy for high-grade and recurrent meningioma: a retrospective chart review
BMC Cancer volume 22, Article number: 367 (2022)
High-grade and recurrent meningiomas are often treatment resistant and pose a therapeutic challenge after surgical and radiation therapy (RT) failure. Temozolomide (TMZ) is a DNA alkylating agent that appears to have a radiosensitizing effect when used in combination with RT and may be worthwhile in meningioma treatment. Thus, we investigated the potential efficacy of concomitant RT plus TMZ compared to historical controls of just RT used in the treatment of high-grade and recurrent meningiomas.
We performed a retrospective analysis of patients with meningioma treated at the University of Colorado with TMZ chemoradiation. Progression free survival (PFS) and overall survival (OS) were calculated from the start of chemoradiation to local recurrence or death, respectively.
Eleven patients (12 tumors) were treated with chemoradiation with a median follow-up of 41.5 months. There were two WHO grade 1, eight grade 2 and two grade 3 meningiomas. Three patients died during the follow-up period—one being disease related (11.1%). Two patients had meningioma recurrence—at 2.3 months (WHO grade 3), and 5.4 years (WHO grade 2). Three-year OS and PFS for grade 2 meningiomas were each 88%. Historical controls demonstrate a 3-year median OS and PFS of 83% and 75.8%, respectively.
Treatment options are limited for meningiomas after local failure. In this study, TMZ chemoradiation demonstrated no significant difference in PFS and OS in the treatment of grade 2 meningiomas compared to historic controls. Further study is warranted to find novel methods for the treatment of malignant and recurrent meningiomas.
Meningiomas comprise about 30% of all intracranial tumors making them the most common primary intracranial neoplasm of middle to late adulthood [1,2,3,4,5]. 80–90% of meningiomas are classified as benign (WHO grade 1) and surgical excision is a common first line treatment . Gross total resection (GTR) can be curative and is often an obtainable objective due to their circumscribed nature depending largely on location and involvement of surrounding structures [2,3,4,5,6,7]. In contrast, the other 10–20% of meningiomas are either classified as WHO grade 2 (atypical) or 3 (anaplastic) due to histologic features or local invasion of surrounding brain parenchyma [2, 7]. Higher grade meningiomas carry a much higher risk of recurrence, and quite frequently adjuvant treatment is recommended. Unfortunately, there is limited data supporting any systemic therapy options for progressive and recurrent meningioma, with no current systemic therapy guidelines [2,3,4]. While radiation can be a primary treatment paradigm for meningioma, it also is commonly used as adjuvant therapy after surgery and is often recommended for grade 3 tumors even after GTR and following any partial resection of grade 1 or 2 meningiomas [3, 4, 6]. Radiation is also used for treatment of recurrent disease, which can otherwise be difficult to treat. For this reason, finding novel ways to treat malignant and recurrent meningiomas remains important.
Temozolomide (TMZ) is an alkylating agent that is currently used to treat glioblastomas and brain metastases with therapeutic efficacy [8,9,10]. By interfering with DNA-repair enzymes, it can act synergistically with radiation therapy (RT) by making tumors more radiosensitive. Thus far, there is conflicting evidence of TMZ efficacy in meningioma treatment as a monotherapy. A prospective phase II trial resulted in none of the patients remaining progression free six months post initiation of adjuvant TMZ therapy . Subsequently, two case reports have identified patients that have achieved remarkable halting of disease progression lasting over a year on adjuvant TMZ therapies [4, 11]. While these studies investigated TMZ as an adjuvant monotherapy, there is a paucity of literature on the nature of TMZ as a concomitant radiosensitizing agent for patients with recurrent/progressive meningiomas. Due to the low toxicity profile, ability to be orally administered, stable pharmacokinetics and ability to cross the blood brain barrier, TMZ is an ideal systemic chemotherapy treatment for patients with brain tumors [4, 8,9,10]. This study evaluated the potential efficacy of concomitant TMZ with RT as a treatment option for patients with grade 2/3 and/or recurrent meningioma.
After obtaining IRB approval, a retrospective chart review was performed to identify all patients with a cranial meningioma diagnosis that had been treated with RT and TMZ at the University of Colorado Hospital between January 1, 2011 and May 1, 2019. Eligible patients had to be treated with RT and concomitant TMZ for their meningioma diagnosis. Eleven patients were identified and received 75 mg/m2/day. All research involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
Electronic medical records and radiological imaging were accessed to identify patient demographics, histological grading and treatment course. Additionally, adverse events data were collected for TMZ. Progression free survival (PFS) was defined as time from the date of the first radiation session to the date of local recurrence/progression. Local tumor recurrence was defined by increased tumor volume and/ or evidence of new growth in the same location as seen on follow-up MRI when compared to prior MR imaging. All imaging was independently reviewed by a board-certified neuroradiologist. Overall survival (OS) was defined as the first day of radiation treatment to death. PFS and OS were determined using Kaplan–Meier analysis.
A review of the literature was performed of papers published in the past 10 years using the key words: meningioma AND radiation therapy within PubMed. 1402 articles were identified. Articles were eliminated if they used pediatric patient populations, included spinal meningiomas or were not in English. Two hundred and nine papers remained, and abstracts were reviewed for relevance, with further elimination for absence of adjuvant RT, use of radiosurgery, or a greatly divergent fractionated dosing schedule for adjuvant radiation than our patients received. Radiation dosing outside of 40–65 Gy total, not given in fractionated dosing, and outside of 1.5–2.5 Gy per dose were considered greatly divergent. Papers were then excluded if they did not report 3- or 5-year OS or PFS data. Due to differences in the number of participants included in the various studies, analysis was weighted to calculate the aggregated PFS and OS.
Statistical analysis was performed using Prism Graph Pad Version 9.3 (San Diego, CA, USA). PFS and OS were calculated from the start of concomitant treatment to local recurrence or death, respectively. Chi-Square analysis was used to determine if there was any statistically significant difference between 3-year PFS and OS of historical controls and our patients. A p-value of ≤ 0.05 was considered statically significant.
Eleven patients (F = 7, M = 4) with 12 tumors were treated with concomitant TMZ chemoradiation. The median age was 56 years (range, 22–82 years) at time of TMZ treatment initiation. All patients had at least 1 prior surgical resection of their primary tumor and received intensity-modulated radiation therapy (IMRT) with a median dose of 60 Gy (range, 48.6–65 Gy) on a 1.8–2 Gy per treatment fractionated schedule. All patients received TMZ at a dose of 75 mg/m2/day administered at night for 42 days. Only one patient had subsequent rounds of adjuvant TMZ for a total of six cycles taken days 1–5/28. There were two WHO grade 1, eight WHO grade 2 and two WHO grade 3 meningiomas (Table 1). The median follow-up was 41.5 months. Three of 11 patients died during the follow-up period; one being disease related from anaplastic meningioma metastasis (11.1%), and two non-meningioma related. Of the non-related deaths, one patient died from a pulmonary embolism with a known deep vein thrombosis in the setting of known cranial hemorrhages, and one patient from death from a traumatic subdural hematoma (Table 1 and Fig. 1). Two patients had meningioma recurrence during the follow-up period, one with a WHO grade 3 meningioma at 2.3 months, and one additional patient at 5.4 years (WHO grade 2).
Thirty-two papers, totaling 2585 patients, comprised the historical controls. The majority were retrospective papers with 12.5% being prospective. 1298 had WHO grade 1 meningiomas, 1177 WHO grade 2, and 110 WHO grade 3 [12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44]. All patients received concomitant RT after surgical resection. Sample size, weighted average, median and range were calculated for 3- and 5- year OS and PFS by meningioma grade. Only 5-year PFS and OS intervals were calculated for grade 1 meningiomas due to their relative stability and were found to have a weighted average of 87.1% and 88.8%, respectively. The weighted average PFS for grade 2 meningiomas at 3 and 5 years are 82.3% and 68.9% with weighted average OS at 3 and 5 years being 89% and 77.4%, respectively. The median 3-year OS and PFS for WHO grade 2 meningiomas was 83% and 75.8%, respectively. Weighted average PFS and OS at 3 years for grade 3 meningiomas is 28.6% and 36.2% and at 5 years it is 15.8% and 33.8%, respectively. The weighted average was calculated to take into consideration the different population sizes of each paper so that papers with a larger sample size were weighted greater than those with a smaller sample size.
Six-month PFS was 91.7%, with 83.3% remaining without local recurrence at last follow-up. The 3-year OS and PFS for grade 2 meningiomas was 88% and 88%, respectively (Fig. 2). At 3 years, only one patient with a WHO grade 2 meningioma had passed away unrelated to her meningioma less than 1 year after treatment initiation. All seven other tumors had no local progression at 3 years. No statistical difference between 3-year PFS (χ2 = 0.162, p = 0.687) and OS (χ2 = 0.0209, p = 0.885) was determined between WHO grade 2 meningiomas treated with TMZ and RT chemoradiation and historical controls of concomitant RT.
Of the eleven patients receiving concomitant RT and TMZ, 7 patients experienced mild fatigue, 7 patients experienced nausea, and 2 patients experienced pancytopenia. Of the seven patients with nausea, all but two cases were mild, and all patients were successfully managed with anti-emetics. One patient with severe nausea had a 10-pound weight loss secondary to the nausea and poor oral intake, requiring nutritional consultation, meal supplementation and anti-emetics. Two patients experienced hematologic toxicity: one patient had pancytopenia while the other had leukopenia and thrombocytopenia.
The majority of meningiomas are WHO grade 1 and thus GTR is largely curative and an obtainable objective [1,2,3,4,5,6,7]. High grade and recurrent meningiomas still pose a therapeutic and surgical challenge. For higher grade meningiomas, there are few treatment options and OS for these patients at 5 years is 78–91% and 35–79% for grade 2 and 3 meningiomas, respectively . Our historical control data falls slightly lower than these reported ranges for 5-year OS when data is aggregated and weighted for study population size.
Currently, standard of care for high grade meningiomas and those that are sub-totally resected is adjuvant RT. Recurrent meningiomas are often treated the same with tumor debulking and adjuvant RT [3, 5, 6]. Unfortunately, recurrent tumors tend to be higher grade meningiomas and recurrent grade 2 and 3 tumors do not demonstrate proven survival benefit from adjuvant RT. Zhu et al. (2019) found no significant correlation between post-operative radiation and outcome for recurrent high grade meningiomas.
For cases that are refractory to this standard of care, there are limited systemic options, and there is a paucity of data indicating efficacy of any chemotherapeutic option. This portends poor outcomes for patients with high grade and refractory meningiomas [2,3,4]. TMZ has been used in patients with glioblastoma and concomitant RT plus TMZ followed by several cycles of adjuvant TMZ and demonstrates a statistically significant survival benefit when compared to RT alone . In brain metastases from lung adenocarcinoma, concomitant TMZ plus RT demonstrates a benefit over RT alone . Thus, there is literature showing a benefit of concomitant chemoradiation over RT alone in different CNS tumors. Due to the demonstrated benefit of TMZ as a radiosensitizing agent in other intracranial tumors, the favorable side effect profile and ease of administration, this chemotherapeutic agent may be useful in patients with high grade and recurrent meningiomas.
Our study had a PFS and OS of 88%—with one patient passing away unrelated to her meningioma about 1 year after initiation of concomitant treatment. All seven other tumors had no progression at 3 years. In comparison, the historical controls found a 3-year average and median PFS of 82.3% and 75.8% respectively and 3-year average and median OS of 89% and 83% respectively. Unfortunately, the observations of our study were not statistically significant when compared to historical controls at 3-years.
TMZ has a favorable side effect profile with the main side effects involving myelosuppression, as well as nonhematological toxicities resulting in fatigue, nausea, anorexia, vomiting and dizziness [4, 8, 9]. Seven patients experienced mild fatigue, seven experienced nausea, one of which had anorexia resulting in weight loss. These side effects were able to be sufficiently medically managed and did not alter the treatment course. Two patients had hematologic toxicities, with one patient stopping TMZ at 25 of 28 concomitant treatments, and the other patient able to complete the full chemoradiation course. Overall, TMZ was well tolerated by our patients on an outpatient basis.
Our study, and use of TMZ in other patient populations, have demonstrated the safety and tolerance of this chemotherapeutic by patients while having potential efficacy in patients with high grade and/or recurrent meningioma. Prospective clinical trials with a larger sample size are warranted to investigate the efficacy of concomitant treatment in meningioma.
Major limitations of this study are the short follow up period and small sample size. Meningiomas, even higher grade 2 and 3 tumors, are generally slow to develop and thus studies often have to look at longitudinal data over a decade to demonstrate median PFS or OS. Furthermore, recurrent and progressive meningioma are uncommon, making case accumulation difficult and management strategies diverse.
High grade and recurrent meningiomas demonstrate a therapeutic challenge with few efficacious options for control after primary surgical excision. Treatment of recurrent and high grade meningiomas treated with concomitant TMZ and RT is safe but treatment showed no statistically significant difference in outcome after three years in comparison to historical controls. Further study is warranted to see if there truly is a benefit to concomitant chemoradiation treatment for the management of high grade and recurrent meningiomas.
Availability of data and materials
The data that support the findings of this study are not publicly available due to their containing information that could compromise the privacy of research participants but are available from the corresponding author upon request.
Progression Free Survival
Gross Total Resection
Intensity Modulated Radiation Therapy
Chamberlain MC, Tsao-Wei DD, Groshen S. Temozolomide for treatment-resistant recurrent meningioma. Neurol. 2004;62:1210–2. https://doi.org/10.1212/01.Wnl.0000118300.82017.F4.
Dasanu CA, Samara Y, Codreanu I, et al. Systemic therapy for relapsed/refractory meningioma: is there potential for antiangiogenic agents? J Oncol Pharm Pract. 2019;25:638–47. https://doi.org/10.1177/1078155218799850.
Le Rhun E, Taillibert S, Chamberlain MC. Systemic therapy for recurrent meningioma. Expert Rev Neurother. 2016;16:889–901. https://doi.org/10.1080/14737175.2016.1184087.
Scorsetti M, Alongi F, Clerici E, et al. Temozolomide combined with radiotherapy in the treatment of recurrent cranial meningioma previously treated with multiple surgical resections and two sessions of radiosurgery: a case report and literature review. Tumori J. 2012;98:e67–71. https://doi.org/10.1177/030089161209800321.
Zhu H, Bi WL, Aizer A, et al. Efficacy of adjuvant radiotherapy for atypical and anaplastic meningioma. Cancer Med. 2019;8:13–20. https://doi.org/10.1002/cam4.1531.
Bi WL, Dunn IF. Current and emerging principles in surgery for meningioma. Chin Clin Oncol. 2017;6:S7. https://doi.org/10.21037/cco.2017.06.10.
Goldbrunner R, Minniti G, Preusser M, et al. EANO guidelines for the diagnosis and treatment of meningiomas. Lancet Oncol. 2016;17:e383–91. https://doi.org/10.1016/S1470-2045(16)30321-7.
Cui C, Zhou L, Lian B, et al. Safety and efficacy of apatinib combined with temozolomide in advanced melanoma patients after conventional treatment failure. Transl Oncol. 2018;11:1155–9. https://doi.org/10.1016/j.tranon.2018.07.009.
Li J, Chai X, Cao Y, et al. Intensity-modulated radiation therapy combined with concomitant temozolomide for brain metastases from lung adenocarcinoma. Oncol Lett. 2018;16:4285–90. https://doi.org/10.3892/ol.2018.9171.
Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J of Med. 2005;352:987–96. https://doi.org/10.1056/NEJMoa043330.
Pellerino A, Soffietti R, Rudà R. Temozolomide for recurrent meningiomas: a case-report with unexpected clinical and radiological response. J Neurooncol. 2016;127:201–3. https://doi.org/10.1007/s11060-015-2016-6.
Abolfotoh M, Tavanaiepour D, Hong C, et al. Primary calcified rhabdoid meningioma of the cranio-cervical junction: a case report and review of literature. J Craniovertebr Junction Spine. 2012;3:32–7. https://doi.org/10.4103/0974-8237.110127.
Adeberg S, Hartmann C, Welzel T, et al. Long-term outcome after radiotherapy in patients with atypical and malignant meningiomas—clinical results in 85 patients treated in a single institution leading to optimized guidelines for early radiation therapy. Int J Radiat Oncol Biol Phys. 2012;83:859–64. https://doi.org/10.1016/j.ijrobp.2011.08.010.
Adeberg S, Welzel T, Rieken S, et al. Prior surgical intervention and tumor size impact clinical outcome after precision radiotherapy for the treatment of optic nerve sheath meningiomas (ONSM). Radiat Oncol. 2011;6:117. https://doi.org/10.1016/j.ijrobp.2011.08.010.
Aizer AA, Arvold ND, Catalano P, et al. Adjuvant radiation therapy, local recurrence, and the need for salvage therapy in atypical meningioma. Neurooncol. 2014;16:1547–53. https://doi.org/10.1093/neuonc/nou098.
Albert A, Lee A, Vijayakumar S, et al. Adjuvant treatment of meningioma with stereotactic radiation surgery and hypofractionated stereotactic radiation surgery: patterns of care and survival in a large, hospital database. Adv Radiat Oncol. 2018;3:280–7. https://doi.org/10.1016/j.adro.2018.04.004.
Anvari K, Hosseini S, Rahighi S, et al. Intracranial meningiomas: prognostic factors and treatment outcome in patients undergoing postoperative radiation therapy. Adv Biomed Res. 2016;5:83–83. https://doi.org/10.4103/2277-9175.182214.
Askoxylakis V, Zabel-du Bois A, Schlegel W, et al. Patterns of failure after stereotactic radiotherapy of intracranial meningioma. J Neurooncol. 2010;98:367–72. https://doi.org/10.1007/s11060-009-0084-1.
Balasubramanian SK, Sharma M, Silva D, et al. Longitudinal experience with WHO grade III (anaplastic) meningiomas at a single institution. J Neurooncol. 2017;131:555–63.
Boulle G, Bracci S, Hitchcock K, et al. Treatment of grade II–III intracranial meningioma with helical tomotherapy. J Clin Neurosci. 2019;59:190–6. https://doi.org/10.1016/j.jocn.2018.10.073.
Buglione M, De Bari B, Trevisan F, et al. Role of external beam radiotherapy in the treatment of relapsing meningioma. Med Oncol. 2014;31:866. https://doi.org/10.1007/s12032-014-0866-y.
Cain SA, Smoll NR, Van Heerden J, et al. Atypical and malignant meningiomas: considerations for treatment and efficacy of radiotherapy. J Clin Neurosci. 2015;22:1742–8. https://doi.org/10.1016/j.jocn.2015.03.054.
Chen WC, Hara J, Magill ST, et al. Salvage therapy outcomes for atypical meningioma. J Neurooncol. 2018;138:425–33. https://doi.org/10.1007/s11060-018-2813-9.
Choi Y, Lim DH, Yu JI, et al. Prognostic value of Ki-67 labeling index and postoperative radiotherapy in WHO grade II meningioma. Am J Clin Oncol. 2018;41:18–23.
Chung LK, Mathur I, Lagman C, et al. Stereotactic radiosurgery versus fractionated stereotactic radiotherapy in benign meningioma. J Clin Neurosci. 2017;36:1–5. https://doi.org/10.1016/j.jocn.2016.10.009.
Detti B, Scoccianti S, Di Cataldo V, et al. Atypical and malignant meningioma: outcome and prognostic factors in 68 irradiated patients. J Neurooncol. 2013;115:421–7. https://doi.org/10.1007/s11060-013-1239-7.
Graffeo CS, Leeper HE, Perry A, et al. Revisiting adjuvant radiotherapy after gross total resection of world health organization grade II meningioma. World Neurosurg. 2017;103:655–63. https://doi.org/10.1016/j.wneu.2017.04.095.
Hammouche S, Clark S, Wong AHL, et al. Long-term survival analysis of atypical meningiomas: survival rates, prognostic factors, operative and radiotherapy treatment. Acta Neurochir. 2014;156:1475–81. https://doi.org/10.1007/s00701-014-2156-z.
Jenkinson MD, Waqar M, Farah JO, et al. Early adjuvant radiotherapy in the treatment of atypical meningioma. J Clin Neurosci. 2016;28:87–92. https://doi.org/10.1016/j.jocn.2015.09.021.
Kumar N, Kumar R, Khosla D, et al. Survival and failure patterns in atypical and anaplastic meningiomas: a single-center experience of surgery and postoperative radiotherapy. J Cancer Res Ther. 2015;11:735.
Lee KD, DePowell JJ, Air EL, et al. Atypical meningiomas: is postoperative radiotherapy indicated? Neurosurg Focus. 2013;35:E15. https://doi.org/10.3171/2013.9.Focus13325.
Masalha W, Heiland DH, Delev D, et al. Survival and prognostic predictors of anaplastic meningiomas. World Neurosurg. 2019;131:e321–8. https://doi.org/10.1016/j.wneu.2019.07.148.
Masalha W, Heiland DH, Franco P, et al. Atypical meningioma: progression-free survival in 161 cases treated at our institution with surgery versus surgery and radiotherapy. J Neurooncol. 2018;136:147–54. https://doi.org/10.1007/s11060-017-2634-2.
Onodera S, Aoyama H, Katoh N, et al. Long-term outcomes of fractionated stereotactic radiotherapy for intracranial skull base benign meningiomas in single institution. Jpn J Clin Oncol. 2011;41:462–8.
Pant S, Tonse R, Kannan S, et al. Impact of timing of radiation therapy on outcomes in atypical meningioma: a clinical audit. Pract Radiat Oncol. 2018;8:e275–84. https://doi.org/10.1016/j.prro.2018.01.010.
Press R, Prabhu R, Appin C, et al. Patterns of failure for grade 2/3 meningioma treated with reduced margin intensity modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2013;87:S158.
Shakir SI, Souhami L, Petrecca K, et al. Prognostic factors for progression in atypical meningioma. J Neurosurg. 2018;129:1240. https://doi.org/10.3171/2017.6.Jns17120.
Sun SQ, Cai C, Murphy RKJ, et al. Management of atypical cranial meningiomas, part 2: predictors of progression and the role of adjuvant radiation after subtotal resection. Neurosurg. 2014;75:356–63. https://doi.org/10.1227/neu.0000000000000462.
Sun SQ, Kim AH, Cai C, et al. Management of atypical cranial meningiomas, part 1: predictors of recurrence and the role of adjuvant radiation after gross total resection. Neurosurg. 2014;75:347–55. https://doi.org/10.1227/neu.0000000000000461.
Soldà F, Wharram B, De Ieso PB, et al. Long-term efficacy of fractionated radiotherapy for benign meningiomas. Radiother Oncol. 2013;109:330–4. https://doi.org/10.1016/j.radonc.2013.10.006.
Tanzler E, Morris CG, Kirwan JM, et al. Outcomes of WHO grade I meningiomas receiving definitive or postoperative radiotherapy. Int J Radiat Oncol Biol Phys. 2011;79:508–13. https://doi.org/10.1016/j.ijrobp.2009.11.032.
van Alkemade H, de Leau M, Dieleman EMT, et al. Impaired survival and long-term neurological problems in benign meningioma. Neurooncol. 2012;14:658–66. https://doi.org/10.1093/neuonc/nos013.
Weber DC, Ares C, Villa S, et al. Adjuvant postoperative high-dose radiotherapy for atypical and malignant meningioma: a phase-II parallel non-randomized and observation study (EORTC 22042–26042). Radiother Oncol. 2018;128:260–5. https://doi.org/10.1016/j.radonc.2018.06.018.
Zhi M, Girvigian MR, Miller MJ, et al. Long-term outcomes of newly diagnosed resected atypical meningiomas and the role of adjuvant radiotherapy. World Neurosurg. 2019;122:e1153–61. https://doi.org/10.1016/j.wneu.2018.11.006.
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This retrospective chart review study involving human participants was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The Human Investigation Committee (IRB) of University of Colorado approved this study and waived the need for informed consent for patient participation.
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Belanger, K., Ung, T.H., Damek, D. et al. Concomitant Temozolomide plus radiotherapy for high-grade and recurrent meningioma: a retrospective chart review. BMC Cancer 22, 367 (2022). https://doi.org/10.1186/s12885-022-09340-7
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