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  1. In this meta-analysis, we conducted a comparative analysis of the safety and efficacy of hypofractionated and conventional fractionated radiotherapy in individuals who had undergone surgery for breast cancer.

    Authors: Yongkai Lu, Beina Hui, Di Yang, Yi Li, Binglin Li, Luping Zhou, Lei Xu, Fengwen Tang, Wei Wang, Ruijuan Chen and Dongli Zhao
    Citation: BMC Cancer 2024 24:181
    Content type: Research Published on:

  3. Men with breast cancer experience unique physical and emotional challenges. However, a thorough understanding of these experiences including the psychosocial effects and supportive care needs have received les...

    Authors: Mary Abboah-Offei, Jonathan Bayuo, Yakubu Salifu, Oladayo Afolabi and Theophilus N. Akudjedu
    Citation: BMC Cancer 2024 24:179
    Content type: Research Published on:

  5. Neoadjuvant chemoradiotherapy (nCRT) and surgery have been recommended as the standard treatments for locally advanced esophageal squamous cell carcinoma (ESCC). In addition, nodal metastases decreased in freq...

    Authors: Run-Da Lu, Zheng-Dao Wei, Yi-Xin Liu, Dong Tian, Han-Lu Zhang, Qi-Xin Shang, Wei-Peng Hu, Lin Yang, Yu-Shang Yang and Long-Qi Chen
    Citation: BMC Cancer 2024 24:177
    Content type: Research Published on:

  6. This study aimed to evaluate the efficacy and side effects of first-line afatinib treatment in a real-world setting in Vietnam.

    Authors: Cam Phuong Pham, Thi Thai Hoa Nguyen, Anh Tu Do, Tuan Khoi Nguyen, Thi Anh Thu Hoang, Tuan Anh Le, Dinh Thy Hao Vuong, Dac Nhan Tam Nguyen, Van Khiem Dang, Thi Oanh Nguyen, Van Luan Pham, Minh Hai Nguyen, Thi Huyen Trang Vo, Hung Kien Do, Ha Thanh Vu, Thi Thuy Hang Nguyen…
    Citation: BMC Cancer 2024 24:176
    Content type: Research Published on:

  7. Targeted drugs are the main methods of RCC treatment. However, drug resistance is common in RCC patients, in-depth study of the drug-resistant mechanism is essential.

    Authors: Fangzhen Cai, Jianwei Li, Yanmei Zhang, Sihuai Huang, Wenbin Liu, Weifeng Zhuo and Chengzhi Qiu
    Citation: BMC Cancer 2024 24:175
    Content type: Research Published on:

  8. High levels of physical activity are associated with reduced risk of the blood cancer multiple myeloma (MM). MM is preceded by the asymptomatic stages of monoclonal gammopathy of undetermined significance (MGU...

    Authors: A Emery, S Moore, J Crowe, J Murray, O Peacock, D Thompson, F Betts, S Rapps, L Ross, D Rothschild-Rodriguez, A Arana Echarri, R Davies, R Lewis, DX Augustine, A Whiteway, Z Afzal…
    Citation: BMC Cancer 2024 24:174
    Content type: Research Published on:

  9. Copy-number alterations (CNAs) are a hallmark of cancer and can regulate cancer cell states via altered gene expression values. Herein, we have developed a copy-number impact (CNI) analysis method that quantif...

    Authors: Sanaz Jamalzadeh, Jun Dai, Kari Lavikka, Yilin Li, Jing Jiang, Kaisa Huhtinen, Anni Virtanen, Jaana Oikkonen, Sakari Hietanen, Johanna Hynninen, Anna Vähärautio, Antti Häkkinen and Sampsa Hautaniemi
    Citation: BMC Cancer 2024 24:173
    Content type: Research Published on:

  10. Epithelioid sarcoma is a rare soft tissue sarcoma characterized by SMARCB1/INI1 deficiency. Much attention has been paid to the selective EZH2 inhibitor tazemetostat, where other systemic treatments are genera...

    Authors: Lu Xie, Xin Sun, Jie Xu, Xin Liang, Kuisheng Liu, Kunkun Sun, Rongli Yang, Xiaodong Tang and Wei Guo
    Citation: BMC Cancer 2024 24:172
    Content type: Research Published on:

  11. Radiotherapy delivery regimens can vary between a single fraction (SF) and multiple fractions (MF) given daily for up to several weeks depending on the location of the cancer or metastases. With limited eviden...

    Authors: Robert Olson, Hadassah Abraham, Curtis Leclerc, Alexander Benny, Sarah Baker, Quinn Matthews, Nick Chng, Alanah Bergman, Benjamin Mou, Emma M. Dunne, Devin Schellenberg, Will Jiang, Elisa Chan, Siavash Atrchian, Shilo Lefresne, Hannah Carolan…
    Citation: BMC Cancer 2024 24:171
    Content type: Study Protocol Published on:

  12. The prognosis of SCLC is poor and difficult to predict. The aim of this study was to explore whether a model based on radiomics and clinical features could predict the prognosis of patients with limited-stage ...

    Authors: Jiehan Wu, Yuntao Zhou, Chang Xu, Chengwen Yang, Bingxin Liu, Lujun Zhao, Jiawei Song, Wei Wang, Yining Yang and Ningbo Liu
    Citation: BMC Cancer 2024 24:170
    Content type: Research Published on:

  13. This study aimed to compare the efficacy of focused ultrasound (FUS) and the loop electrosurgical excision procedure (LEEP) for the treatment of cervical high-grade squamous intraepithelial lesions (HSILs) amo...

    Authors: Linlin Xiao, Xu Dong, Jiangchuan Sun, Xuerui Zhang, Qing Feng and Shufang Chang
    Citation: BMC Cancer 2024 24:169
    Content type: Research Published on:

  14. Oxaliplatin-induced peripheral neuropathy (OIPN) in general and painful OIPN in particular is a debilitating late effect that severely affects cancer survivors’ quality of life and causes premature cessation o...

    Authors: Nina Lykkegaard Gehr, Páll Karlsson, Signe Timm, Signe Christensen, Christian Andreas Hvid, Jana Peric, Torben Frøstrup Hansen, Lotte Lauritzen, Nanna Brix Finnerup and Lise Ventzel
    Citation: BMC Cancer 2024 24:168
    Content type: Study Protocol Published on:

  15. Breast carcinoma (BC) ranks as a predominant malignancy and constitutes the second principal cause of mortality among women globally. Epirubicin stands as the drug of choice for BC therapeutics. Nevertheless, ...

    Authors: Yunwei Zhang, Yunping Guan, Xinyu Zheng and Chenyang Li
    Citation: BMC Cancer 2024 24:167
    Content type: Research Published on:

  16. Osteosarcoma (OS) is a highly malignant tumor, and its dysregulated lipid metabolism is associated with tumorigenesis and unfavorable prognosis. Interestingly, long noncoding RNAs (lncRNAs) have emerged as piv...

    Authors: Feng Cai, Luhua Liu, Yuan Bo, Wenjing Yan, Xuchang Tao, Yuanxiang Peng, Zhiping Zhang, Qi Liao and Yangyan Yi
    Citation: BMC Cancer 2024 24:166
    Content type: Research Published on:

  17. To improve the prognosis of patients with metastatic colorectal cancer (mCRC), investigating predictive biomarkers of their prognosis and chemotherapeutic responsiveness is necessary. This study aimed to analy...

    Authors: Kei Furuya, Masao Nakajima, Ryouichi Tsunedomi, Yuki Nakagami, Ming Xu, Hiroto Matsui, Yukio Tokumitsu, Yoshitaro Shindo, Yusaku Watanabe, Shinobu Tomochika, Noriko Maeda, Michihisa Iida, Nobuaki Suzuki, Shigeru Takeda, Shoichi Hazama, Tatsuya Ioka…
    Citation: BMC Cancer 2024 24:165
    Content type: Research Published on:

  18. For high-risk stageIImismatch repair deficient (dMMR) colon cancers, the benefit of adjuvant chemotherapy remains debatable. The principal aim of this study was to evaluate the prognostic value of high-risk fa...

    Authors: Leen Liao, Jinghua Tang, Zhigang Hong, Wu Jiang, Yuan Li, Lingheng Kong, Kai Han, Zhenlin Hou, Chenzhi Zhang, Chi Zhou, Linjie Zhang, Qiaoqi Sui, Binyi Xiao, Weijian Mei, Jiehai Yu, Wanjun Yang…
    Citation: BMC Cancer 2024 24:164
    Content type: Research Published on:

  19. Despite advancements in managing metastatic clear cell renal carcinoma (mccRCC) through antiangiogenic tyrosine kinase inhibitors and immunotherapy, there remains a demand for novel treatments for patients exp...

    Authors: David Kryza, Armelle Vinceneux, Anne-Sophie Bidaux, Gwenaelle Garin, Delphine Tatu, Claire Cropet, Jean-Noël Badel, David Perol and Anne-Laure Giraudet
    Citation: BMC Cancer 2024 24:163
    Content type: Study Protocol Published on:

  20. Colorectal cancer (CRC) is a common malignancy worldwide. MicroRNAs (miRNAs) are important epigenetic alterations that notably impact various physiological and pathological processes by acting as negative regu...

    Authors: Bayan Mehrjoei, Lida Haghnazari, Homayoon Bashiri and Nayebali Rezvani
    Citation: BMC Cancer 2024 24:162
    Content type: Research Published on:

  21. In 2020, the highest incidence and mortality from cervical cancer (CC) were detected in low and middle-income countries. CC remains a health problem for women living in them. In Mexico, CC ranks second in canc...

    Authors: Lucely Cetina-Pérez, Julissa Luvián-Morales, Merari Delgadillo-González, Denisse Castro-Eguiluz, Tatiana Galicia-Carmona, Kely Rely, Rita Vaca González, Gabriela Lugo-Martínez, Nadia García-Barrientos and Antonio Nateras
    Citation: BMC Cancer 2024 24:161
    Content type: Research Published on:

  22. This study aims to explore the priorities and counselling needs of patients with muscle-invasive bladder cancer faced with a decision between radical cystectomy and trimodality therapy.

    Authors: Flor Verghote, Charles Van Praet, Camille Berquin, Nicolaas Lumen, Karel Decaestecker, Ben Vanneste, Elke Rammant and Valérie Fonteyne
    Citation: BMC Cancer 2024 24:160
    Content type: Research Published on:

  23. This study was designed to evaluate the safety and feasibility of laparoscopic radical cystectomy (LRC) for male octogenarian patients with muscle-invasive bladder cancer (MIBC). Briefly, a total of 57 male oc...

    Authors: Dong-liang Pan, Lu-fang Zhang, Xiao-jian Li, Ke-ping Zhang, Peng-fei Gao, Bing Yang and Ning-chen Li
    Citation: BMC Cancer 2024 24:159
    Content type: Research Published on:

  24. Guidelines recommend cardiovascular risk assessment and counseling for cancer survivors. For effective implementation, it is critical to understand survivor cardiovascular health (CVH) profiles and perspective...

    Authors: Kathryn E. Weaver, Emily V. Dressler, Sydney Smith, Chandylen L. Nightingale, Heidi D. Klepin, Simon Craddock Lee, Brian J. Wells, W. Gregory Hundley, Joseph A. DeMari, Sarah N. Price and Randi E. Foraker
    Citation: BMC Cancer 2024 24:158
    Content type: Research Published on:

  26. Lactate dehydrogenase (LDHs) is an enzyme involved in anaerobic glycolysis, including LDHA, LDHB, LDHC and LDHD. Given the regulatory role in the biological progression of certain tumors, we analyzed the role ...

    Authors: Shengnan Wang, Xingwei Wu, Xiaoming Wu, Jin Cheng, Qianyi Chen and Zhilin Qi
    Citation: BMC Cancer 2024 24:156
    Content type: Research Published on:

  27. Breast cancer remains a significant health challenge worldwide, necessitating the identification of reliable biomarkers for early detection, accurate prognosis, and targeted therapy.

    Authors: Ali Golestan, Ahmad Tahmasebi, Nafiseh Maghsoodi, Seyed Nooreddin Faraji, Cambyz Irajie and Amin Ramezani
    Citation: BMC Cancer 2024 24:155
    Content type: Research Published on:

  28. The increasing cancer burden calls for reliably assessed changes in the hospitalizations for tumors over time and space in China. This study evaluated trends in hospitalization rate, in-hospital mortality, len...

    Authors: Xinqiang Zhang, Yuanyuan Li, Guifang Zhang, Changsheng Ma, Bo Liu and Yong Yin
    Citation: BMC Cancer 2024 24:154
    Content type: Research Published on:

  29. Neoadjuvant immune checkpoint inhibitors(ICIs) combined with chemotherapy can improve non-small cell lung cancer(NSCLC) patients' pathological responses and show promising improvements in survival. Chronic obs...

    Authors: Weigang Dong, Yan Yin, Shengnan Yang, Bin Liu, Xi Chen, Lina Wang, Yue Su, Yan Jiang, Dongsheng Shi, Daqiang Sun and Jianwen Qin
    Citation: BMC Cancer 2024 24:153
    Content type: Research Published on:

  30. While immunotherapy combined with chemotherapy (Chemo-IO) is generally recognized for providing superior outcomes compared to monotherapy (mono-IO), it is associated with a higher incidence of treatment-relate...

    Authors: Sangwon Shin, Jimin Moon, Chiyoon Oum, Seulki Kim, Soo Ick Cho, Yoojoo Lim, Chan-Young Ock and Seunghwan Shin
    Citation: BMC Cancer 2024 24:152
    Content type: Research Published on:

  31. Breast cancer in Tunisia is often diagnosed at a late stage with long delay in time to consultation and to diagnosis.The aim of this study is to estimate the sensitivity and specificity of the transcutaneous b...

    Authors: Imtinene Belaid, Mohamed Fedy Baya, Saif Ben Ayed, Ali Ben Ayed, Jihen Maatoug, Nawel Zommit, Mohamed Anas Trabelsi, Noureddine Ben Chida, Hedi Khairi, Leila Ben Fatma, Imene Chabchoub, Nouha Ammar, Rym Bourigua, Makrem Hochlaf, Faten Ezzaari and Slim Ben Ahmed
    Citation: BMC Cancer 2024 24:151
    Content type: Research Published on:

  32. The existing staging system cannot meet the needs of accurate survival prediction. Accurate survival prediction for locally advanced cervical cancer (LACC) patients who have undergone concurrent radiochemother...

    Authors: Huiling Liu, Yongbin Cui, Cheng Chang, Zichun Zhou, Yalin Zhang, Changsheng Ma, Yong Yin and Ruozheng Wang
    Citation: BMC Cancer 2024 24:150
    Content type: Research Published on:

  33. Physician-brief advice has been utilized in high-income countries to promote smoking cessation among cancer patients. Empirical evidence on its effectiveness among cancer patients in low and middle-income coun...

    Authors: Olayinka Stephen Ilesanmi, Babalola Faseru, Aanuoluwapo Adeyimika Afolabi, Olukemi Odukoya, Olalekan Ayo-Yusuf, Folahanmi Akinsolu, Akindele Olupelumi Adebiyi and William K. Evans
    Citation: BMC Cancer 2024 24:149
    Content type: Research Published on:

  34. We aimed to identify preoperative predictors of aggressive pathology for cT1 solid renal cell carcinoma (RCC) by combining clinical features with qualitative and quantitative CT parameters, and developed a nom...

    Authors: Keruo Wang, Liang Dong, Songyang Li, Yaru Liu, Yuanjie Niu and Gang Li
    Citation: BMC Cancer 2024 24:148
    Content type: Research Published on:

  35. Pediatric low-grade glioma (pLGG) is essentially a single pathway disease, with most tumors driven by genomic alterations affecting the mitogen-activated protein kinase/ERK (MAPK) pathway, predominantly KIAA1549:...

    Authors: Cornelis M. van Tilburg, Lindsay B. Kilburn, Sébastien Perreault, Rene Schmidt, Amedeo A. Azizi, Ofelia Cruz-Martínez, Michal Zápotocký, Katrin Scheinemann, Antoinette Y. N. Schouten-van Meeteren, Astrid Sehested, Enrico Opocher, Pablo Hernáiz Driever, Shivaram Avula, David S. Ziegler, David Capper, Arend Koch…
    Citation: BMC Cancer 2024 24:147
    Content type: Study Protocol Published on:

  36. Life expectancy of patients with metastatic castration-resistant prostate cancer (mCRPC) is still limited despite several systemic treatments. Within five years after diagnosis of primary prostate cancer, 10–2...

    Authors: Sui wai Ling, Astrid A. M. van der Veldt, Mark Konijnenberg, Marcel Segbers, Eline Hooijman, Frank Bruchertseifer, Alfred Morgenstern, Erik de Blois and Tessa Brabander
    Citation: BMC Cancer 2024 24:146
    Content type: Study Protocol Published on:

  38. Up to 70% of people diagnosed with upper gastrointestinal (GI) tract or hepato-pancreato-biliary (HPB) cancers experience substantial reductions in quality of life (QoL), including high distress levels, pain, ...

    Authors: Patricia M Livingston, Natalie Winter, Anna Ugalde, Liliana Orellana, Antonina Mikocka-Walus, Michael Jefford, John Zalcberg, Neil Orford, Alison M Hutchinson, Andrew Barbour, Nicole Kiss, Bernard Mark Smithers, David I Watson, Nikki McCaffrey and Victoria White
    Citation: BMC Cancer 2024 24:144
    Content type: Study Protocol Published on:

  39. The COVID-19 pandemic might have delayed cancer diagnosis and management. The aim of this systematic review was to compare the initial tumor stage of new cancer diagnoses before and after the pandemic.

    Authors: Simon Marty, Guillaume Lamé, Etienne Guével, Sonia Priou, Gilles Chatellier, Christophe Tournigand and Emmanuelle Kempf
    Citation: BMC Cancer 2024 24:143
    Content type: Research Published on:

  40. The prognostic significance of mast cells and different phenotypes of macrophages in the microenvironment of hepatocellular carcinoma (HCC) following resection is unclear. We aimed in this study to assess the ...

    Authors: Esraa Ali, Lenka Červenková, Richard Pálek, Filip Ambrozkiewicz, Petr Hošek, Ondrej Daum, Václav Liška, Kari Hemminki and Andriy Trailin
    Citation: BMC Cancer 2024 24:142
    Content type: Research Published on:

  41. Gastric cancer (GC) remains a predominant form of malignant tumor globally, necessitating innovative non-surgical therapeutic approaches. This investigation aimed to delineate the expression landscape of macro...

    Authors: Zhijun Hong, Peizhen Wen, Kang Wang, Xujin Wei, Wen Xie, Shihao Rao, Xin Chen, Jingjing Hou and Huiqin Zhuo
    Citation: BMC Cancer 2024 24:141
    Content type: Research Published on:

  42. Glioblastoma multiforme (GBM) is the most aggressive brain cancer with a poor prognosis. Therefore, the correlative molecular markers and molecular mechanisms should be explored to assess the occurrence and tr...

    Authors: Wangyang Yu, Minfeng Zhou, Huifang Niu, Jinxiao Li, Qiumeng Li, Xiaoyun Xu, Fengxia Liang and Chen Rui
    Citation: BMC Cancer 2024 24:140
    Content type: Research Published on:

  43. Identifying lymph node metastasis areas during surgery for early invasive lung adenocarcinoma remains challenging. The aim of this study was to develop a nomogram mathematical model before the end of surgery f...

    Authors: Mengchao Xue, Junjie Liu, Zhenyi Li, Ming Lu, Huiying Zhang, Wen Liu and Hui Tian
    Citation: BMC Cancer 2024 24:139
    Content type: Research Published on:

  44. Central nervous system (CNS) tumors are the most common solid tumors in children and the leading cause of cancer-related death in the latter. Currently, the incidence rate exceeds that of leukemia and ranks fi...

    Authors: Bing Yao, Hongying Wang, Xiaomei Wu, Chenyu Wang, Tao Tang, Wenxiu An and Bo Zhu
    Citation: BMC Cancer 2024 24:138
    Content type: Research Published on:

  45. Forkhead-box protein P1 (FOXP1) has been proposed to have both oncogenic and tumor-suppressive properties, depending on tumor heterogeneity. However, the role of FOXP1 in intrahepatic cholangiocarcinoma (ICC) ...

    Authors: Chenwei Tang, Hongkai Zhuang, Huanjun Tong, Xiaopeng Yu, Jialu Chen, Qingbin Wang, Xiaowu Ma, Bingkun Wang, Yonglin Hua, Changzhen Shang and Zhaohui Tang
    Citation: BMC Cancer 2024 24:137
    Content type: Research Published on:

  46. Despite the utilization of immune checkpoint inhibitors (ICIs) in treating numerous types of cancers being approved, their efficacy in tumor control in the clinic is not satisfactory. Since adoptive cell thera...

    Authors: Yi-Ping Hung, Chia-Chun Tu, Jiun-I Lai, Muh-Hwa Yang, Jan-Mou Lee and Yee Chao
    Citation: BMC Cancer 2024 24:136
    Content type: Research Published on:

  47. Glioblastoma is the most frequent and a particularly malignant primary brain tumor with no efficacy-proven standard therapy for recurrence. It has recently been discovered that excitatory synapses of the AMPA-...

    Authors: Sophie Heuer, Ina Burghaus, Maria Gose, Tobias Kessler, Felix Sahm, Philipp Vollmuth, Varun Venkataramani, Dirk Hoffmann, Matthias Schlesner, Miriam Ratliff, Carsten Hopf, Ulrich Herrlinger, Franz Ricklefs, Martin Bendszus, Sandro M. Krieg, Antje Wick…
    Citation: BMC Cancer 2024 24:135
    Content type: Study Protocol Published on:

  48. Neoadjuvant chemotherapy with dual-targeted therapy is the standard treatment for human epidermal growth factor 2 (HER2)-positive breast cancer. Although the dual-targeted therapy has significantly improved th...

    Authors: Zheng-Jun Yang, Fei Xin, Zu-Jin Chen, Yue Yu, Xin Wang and Xu-Chen Cao
    Citation: BMC Cancer 2024 24:134
    Content type: Research Published on:

  49. There are limited and no standard therapies for recurrent glioblastoma. We herein report the antitumour activity and safety of sintilimab, bevacizumab and temozolomide (TMZ) in recurrent glioblastoma.

    Authors: Yinghao Lu, Limin Liao, Kunpeng Du, Jianhua Mo, Xia Zou, Junxian Liang, Jiahui Chen, Wenwen Tang, Liwei Su, Jieping Wu, Junde Zhang and Yujing Tan
    Citation: BMC Cancer 2024 24:133
    Content type: Research Published on:

  50. Treatment summaries and a personalized survivorship care plans based on internationally approved, organ-specific follow-up care recommendations are essential in preserving the health and quality of life for ca...

    Authors: Charlotte Demoor-Goldschmidt, Pascal Veillon, Maxime Esvan, Mathilde Leonard, Sophie Chauvet, Amandine Bertrand, Liana Carausu, Fanny Delehaye, Julien Lejeune, Jérémie Rouger, Pascale Schneider, Caroline Thomas, Frédéric Millot, Line Claude, Julie Leseur, Fernand Missohou…
    Citation: BMC Cancer 2024 24:130
    Content type: Research Published on:

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