Skip to main content

Articles

Page 114 of 335

  1. Therapy targeted to the human epidermal growth factor receptor type 2 (HER2) is used in combination with cytotoxic therapy in treatment of HER2+ breast cancer. Trastuzumab, a monoclonal antibody that targets H...

    Authors: Meghan J. Bloom, Angela M. Jarrett, Todd A. Triplett, Anum K. Syed, Tessa Davis, Thomas E. Yankeelov and Anna G. Sorace
    Citation: BMC Cancer 2020 20:359
    Content type: Research article Published on:

  2. This study aimed to evaluate the efficacy and the safety of polyethylene glycol conjugated granulocyte colony-stimulating factor (PEG-G-CSF) for preventing neutropenia in metastatic colorectal cancer (mCRC) pa...

    Authors: Yusuke Kitagawa, Hiroki Osumi, Eiji Shinozaki, Yumiko Ota, Izuma Nakayama, Takeshi Suzuki, Takeru Wakatsuki, Mariko Ogura, Akira Ooki, Daisuke Takahari, Mitsukuni Suenaga, Keisho Chin and Kensei Yamaguchi
    Citation: BMC Cancer 2020 20:358
    Content type: Research article Published on:

  4. The objective of this study was to investigate real-world EGFR mutation testing in patients with metastatic non-small cell lung cancer (NSCLC) upon progression on first−/second-generation epidermal growth fact...

    Authors: Anne C. Chiang, Ancilla W. Fernandes, Melissa Pavilack, Jennifer W. Wu, François Laliberté, Mei Sheng Duh, Nabil Chehab and Janakiraman Subramanian
    Citation: BMC Cancer 2020 20:356
    Content type: Research article Published on:

  5. This analysis aims at evaluating the impact of multidisciplinary tumor boards on clinical outcome of multiple tumor entities, the effect of the specific number of multidisciplinary tumor boards and potential d...

    Authors: Marius Freytag, Ulrich Herrlinger, Stefan Hauser, Franz G. Bauernfeind, Maria A. Gonzalez-Carmona, Jennifer Landsberg, Jens Buermann, Hartmut Vatter, Tobias Holderried, Thorsten Send, Martin Schumacher, Arne Koscielny, Georg Feldmann, Mario Heine, Dirk Skowasch, Niklas Schäfer…
    Citation: BMC Cancer 2020 20:355
    Content type: Research article Published on:

    The Correspondence to this article has been published in BMC Cancer 2021 21:173

  6. Tumor recurrence and metastasis occur at a high rate in patients with colon cancer. Identification of effective strategies for the treatment of colon cancer is critical. Recently, poly (lactic-co-glycolic acid...

    Authors: Pingping Wu, Qing Zhou, Huayun Zhu, Yan Zhuang and Jun Bao
    Citation: BMC Cancer 2020 20:354
    Content type: Research article Published on:

  7. High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard treatment for multiple myeloma (MM) patients. However, the collection of sufficient peripheral blood st...

    Authors: Sandra Sauer, Petra Pavel, Anita Schmitt, Martin Cremer, Mark Kriegsmann, Thomas Bruckner, Karin Jordan, Patrick Wuchter, Carsten Müller-Tidow and Katharina Kriegsmann
    Citation: BMC Cancer 2020 20:353
    Content type: Research article Published on:

  8. Modified docetaxel, cisplatin, and 5-fluorouracil (mDCF) regimen has become a new standard for the treatment of metastatic or unresectable locally advanced recurrent squamous cell carcinoma of the anus (SCCA) ...

    Authors: Stefano Kim, Bruno Buecher, Thierry André, Marine Jary, François-Clément Bidard, François Ghiringhelli, Éric François, Julien Taieb, Denis Smith, Christelle de la Fouchardière, Jérôme Desramé, Emmanuelle Samalin, Aurélie Parzy, Nabil Baba-Hamed, Olivier Bouché, David Tougeron…
    Citation: BMC Cancer 2020 20:352
    Content type: Study protocol Published on:

  9. The number of people living with soft-tissue and bone sarcomas is increasing due to improved individual therapy and changes in demographics. At present, there are no recommendations for psychological co-treatm...

    Authors: Wolfram Weschenfelder, Sabine Gast-Froehlich, Christian Spiegel, Matthias Vogt and Gunther O. Hofmann
    Citation: BMC Cancer 2020 20:351
    Content type: Research article Published on:

  10. ARID1A has been described as a tumor suppressor gene, participating in chromatin re-modeling, epithelial-mesenchymal-transition and many other cellular and molecular processes. It has been cited as a contribut...

    Authors: Mehran Erfani, Seyed Vahid Hosseini, Maral Mokhtari, Mozhdeh Zamani, Kamran Tahmasebi, Mahvash Alizadeh Naini, Alireza Taghavi, John M. Carethers, Minoru Koi, Hassan Brim, Pooneh Mokarram and Hassan Ashktorab
    Citation: BMC Cancer 2020 20:350
    Content type: Research article Published on:

  11. Testicular germ cell tumours (TGCTs) are characterised by an overall high cisplatin-sensitivity which has been linked to their continued expression of pluripotency factors. Recently, the Nodal signalling pathw...

    Authors: K. Harpelunde Poulsen, J. E. Nielsen, B. Grønkær Toft, U. N. Joensen, L. J. Rasmussen, M. Blomberg Jensen, R. T. Mitchell, A. Juul, E. Rajpert-De Meyts and A. Jørgensen
    Citation: BMC Cancer 2020 20:349
    Content type: Research article Published on:

  12. The relationships among PIK3CA mutations, medication use and tumor progression remains poorly understood. Aspirin use post-diagnosis may modify components of the PI3K pathway, including AKT and mTOR, and has been...

    Authors: Anne Marie McCarthy, Nitya Pradeep Kumar, Wei He, Susan Regan, Michaela Welch, Beverly Moy, A. John Iafrate, Andrew T. Chan, Aditya Bardia and Katrina Armstrong
    Citation: BMC Cancer 2020 20:347
    Content type: Research article Published on:

  14. Familial colorectal cancer type X (FCCTX) is a phenotypically defined subset of hereditary colorectal cancer with unknown and potentially heterogeneous genetic aetiology. FCCTX has been characterized as a colo...

    Authors: Christina Therkildsen, Maria Rasmussen, Lars Smith-Hansen, Thomas Kallemose, Lars Joachim Lindberg and Mef Nilbert
    Citation: BMC Cancer 2020 20:345
    Content type: Research article Published on:

  15. Detection of programmed cell death ligand-1 (PD-L1) by immunohistochemistry (IHC) has been commonly used to predict the efficacy of treatment with PD-1/PD-L1 inhibitors. However, there is limited literature re...

    Authors: Yinying Zou, Liming Xu, Qiusu Tang, Qihan You, Xiaoling Wang, Wei Ding, Jing Zhao and Guoping Ren
    Citation: BMC Cancer 2020 20:344
    Content type: Research article Published on:

  17. Planar-based measurements of lesions in metastatic melanoma have limitations in estimating tumor burden of a patient and in predicting response to treatment. Volumetric imaging might add predictive value to Re...

    Authors: Arwa Ali, Monica Dumbrava, Kylie Riddell, Nina Stewart, Robyn Ward, Ahmed K. Ibrahim and Melvin Chin
    Citation: BMC Cancer 2020 20:342
    Content type: Research article Published on:

  18. Antigen-processing machinery molecules play crucial roles in infectious diseases and cancers. Studies have shown that polymorphisms in endoplasmic reticulum aminopeptidase (ERAP) genes can influence the enzyma...

    Authors: Chuanyin Li, Yaheng Li, Zhiling Yan, Shuying Dai, Shuyuan Liu, Xia Wang, Jun Wang, Xinwen Zhang, Li Shi and Yufeng Yao
    Citation: BMC Cancer 2020 20:341
    Content type: Research article Published on:

  19. To examine the tumor characteristics, treatments and survival outcomes of prostate cancer (PCa) patients with a prostate-specific antigen (PSA) level < 4 ng/ml.

    Authors: Zhibo Zheng, Zhien Zhou, Weigang Yan, Yi Zhou, Chuyan Chen, Hanzhong Li and Zhigang Ji
    Citation: BMC Cancer 2020 20:340
    Content type: Research article Published on:

  20. Patients with metastatic renal cell cancer (mRCC) are commonly treated with the tyrosine kinase inhibitor sunitinib, which blocks signalling from vascular endothelial growth factor (VEGF) - and platelet-derive...

    Authors: Marjut Niinivirta, Maria Georganaki, Gunilla Enblad, Cecilia Lindskog, Anna Dimberg and Gustav J. Ullenhag
    Citation: BMC Cancer 2020 20:339
    Content type: Research article Published on:

  21. Ramucirumab monotherapy as a second-line treatment for advanced gastric cancer (AGC) prolongs survival compared to the best supportive care. However, in clinical practice, ramucirumab monotherapy is sometimes ...

    Authors: Sadayuki Kawai, Naoki Fukuda, Shun Yamamoto, Seiichiro Mitani, Katsuhiro Omae, Takeru Wakatsuki, Ken Kato, Shigenori Kadowaki, Daisuke Takahari, Narikazu Boku, Kei Muro and Nozomu Machida
    Citation: BMC Cancer 2020 20:338
    Content type: Research article Published on:

  22. Concern for cardiovascular disease (particularly atrial fibrillation-AF) among women with breast cancer is becoming a major issue. We aimed at determining the incidence of cardiovascular disease events (AF, ar...

    Authors: Benoîte Mery, Antoine Fouilloux, Elise Rowinski, Judith Catella-Chatron, Jean-Baptiste Guichard, Antoine Da Costa, Fabien Tinquaut, N. Magné and Laurent Bertoletti
    Citation: BMC Cancer 2020 20:337
    Content type: Research article Published on:

  23. The standard treatment for patients with unresectable locally advanced esophageal squamous cell carcinoma (ESCC) is definitive chemoradiotherapy (CRT) using 5-FU plus cisplatin. However, complete response (CR)...

    Authors: Hideaki Bando, Daisuke Kotani, Takahiro Tsushima, Hiroki Hara, Shigenori Kadowaki, Ken Kato, Keisho Chin, Kensei Yamaguchi, Shun-ichiro Kageyama, Hidehiro Hojo, Masaki Nakamura, Hidenobu Tachibana, Masashi Wakabayashi, Miki Fukutani, Yosuke Togashi, Nozomu Fuse…
    Citation: BMC Cancer 2020 20:336
    Content type: Study protocol Published on:

  24. Cancer patients often receive multiple drugs to maximize their therapeutic benefit, treat co-morbidities and counter the adverse effects of chemotherapy. Concomitant administration of multiple drugs increases ...

    Authors: Mohammad Ismail, Sehrash Khan, Fahadullah Khan, Sidra Noor, Hira Sajid, Shazia Yar and Irum Rasheed
    Citation: BMC Cancer 2020 20:335
    Content type: Research article Published on:

  25. Unplanned hospitalization during cancer treatment is costly, can disrupt treatment, and affect patient quality of life. However, incidence and risks factors for hospitalization during lung cancer radiotherapy ...

    Authors: Sarah Z. Hazell, Nicholas Mai, Wei Fu, Chen Hu, Cole Friedes, Alex Negron, Khinh Ranh Voong, Josephine L. Feliciano, Peijin Han, Samantha Myers, Todd R. McNutt and Russell K. Hales
    Citation: BMC Cancer 2020 20:334
    Content type: Research article Published on:

  26. Breast cancer treatment is tailored to the specific cancer subtype. Often, systemic treatment is given prior to surgery. Chemotherapy induces significant endoplasmic reticulum (ER) stress-mediated cell death a...

    Authors: Annat Raiter, Julia Lipovetzki, Ido Lubin and Rinat Yerushalmi
    Citation: BMC Cancer 2020 20:333
    Content type: Research article Published on:

  27. Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. The only drug currently approved for clinical use in the treatment of advanced HCC is sorafenib. However, many patients w...

    Authors: Hanhee Jo, Yusun Park, Taehun Kim, Jisu Kim, Jong Sook Lee, Seon Yoo Kim, Jee-in Chung, Hae yong Ko, Jae-Chul Pyun, Kyung Sik Kim, Misu Lee and Mijin Yun
    Citation: BMC Cancer 2020 20:332
    Content type: Research article Published on:

  28. The gene encoding fibroblast growth factor receptor 1 (FGFR1) is emerging as a therapeutic and prognostic biomarker in various cancer types, including head and neck squamous cell carcinoma (SCC). Here, we investi...

    Authors: Eun Kyung Kim, Yoon Ah Cho, Yoon Woo Koh, Hyang Ae Shin, Byoung Chul Cho and Sun Och Yoon
    Citation: BMC Cancer 2020 20:348
    Content type: Research article Published on:

  29. Stereotactic irradiation (STI) is a primary treatment for patients with newly diagnosed brain metastases. Some of these patients experience local progression, which is difficult to differentiate from radiation...

    Authors: Koichi Mitsuya, Yoko Nakasu, Nakamasa Hayashi, Shoichi Deguchi, Takuma Oishi, Takashi Sugino, Kazuaki Yasui, Hirofumi Ogawa, Tsuyoshi Onoe, Hirofumi Asakura and Hideyuki Harada
    Citation: BMC Cancer 2020 20:331
    Content type: Research article Published on:

  30. Pelvic lymph node dissection (PLND) is one of the most important steps in radical prostatectomy (RP). Not only can PLND provide accurate clinical staging to guide treatment after prostatectomy but PLND can als...

    Authors: Jia-Jun Chen, Zai-Sheng Zhu, Yi-Yi Zhu and Hong-Qi Shi
    Citation: BMC Cancer 2020 20:330
    Content type: Research article Published on:

  32. The prognostic significance of TP53 concurrent mutations in patients with epidermal growth factor receptor (EGFR)- or anaplastic lymphoma kinase (ALK)- mutated advanced non–small-cell lung cancer (NSCLC) who r...

    Authors: Kang Qin, Helei Hou, Yu Liang and Xiaochun Zhang
    Citation: BMC Cancer 2020 20:328
    Content type: Research article Published on:

  33. To discuss some inaccurate parts of a published systematic review and meta-analysis which was about comparison of laparoscopic pancreaticoduodenectomy and open pancreaticoduodenectomy for pancreatic ductal ade...

    Authors: Rui Sun, Yifan Zhang and Zhe Su
    Citation: BMC Cancer 2020 20:327
    Content type: Correspondence Published on:

    The original article was published in BMC Cancer 2019 19:781

  34. Neuroendocrine tumors (NETs) frequently overexpress somatostatin receptors (SSTRs), which is the molecular basis for 68Ga-DOTATOC positron-emission tomography (PET) and radiopeptide therapy (PRRT). However, SSTR ...

    Authors: Manuel Weber, Lukas Kessler, Benedikt Schaarschmidt, Wolfgang Peter Fendler, Harald Lahner, Gerald Antoch, Lale Umutlu, Ken Herrmann and Christoph Rischpler
    Citation: BMC Cancer 2020 20:326
    Content type: Research article Published on:

  35. Sodium channels located in the dorsal root ganglion, particularly Nav1.7 and Nav1.8, encoded by SCN9A and SCN10A, respectively, act as molecular gatekeepers for pain detection. Our aim was to determine the associ...

    Authors: Yuko Tanabe, Seiji Shiraishi, Kenji Hashimoto, Kazutaka Ikeda, Daisuke Nishizawa, Junko Hasegawa, Akihiko Shimomura, Yukinori Ozaki, Nobuko Tamura, Mayu Yunokawa, Kan Yonemori, Toshimi Takano, Hidetaka Kawabata, Kenji Tamura, Yasuhiro Fujiwara and Chikako Shimizu
    Citation: BMC Cancer 2020 20:325
    Content type: Research article Published on:

  36. In this retrospective study, we evaluated the biochemical recurrence rate, metastatic disease progression, and prostate cancer-specific and overall survival in patients curatively treated with external beam ra...

    Authors: Miikka Lehtonen, Lauri Heiskanen, Petri Reinikainen and Pirkko-Liisa Kellokumpu-Lehtinen
    Citation: BMC Cancer 2020 20:324
    Content type: Research article Published on:

  37. Cervical cancer is caused by high-risk Human Papillomavirus (hr-HPV) infection associated with cofactors that has been analyzed as predictors of the remission or persistence of cytological abnormalities remiss...

    Authors: Nayara Nascimento Toledo Silva, Ana Carolina Silva Santos, Verlândia Mendes Nogueira, Cláudia Martins Carneiro and Angélica Alves Lima
    Citation: BMC Cancer 2020 20:323
    Content type: Research article Published on:

  38. Response evaluation of neoadjuvant chemotherapy (NACT) in patients with osteosarcoma is significant for the termination of ineffective treatment, the development of postoperative chemotherapy regimens, and the...

    Authors: Bingsheng Huang, Jifei Wang, Meili Sun, Xin Chen, Danyang Xu, Zi-Ping Li, Jinting Ma, Shi-Ting Feng and Zhenhua Gao
    Citation: BMC Cancer 2020 20:322
    Content type: Research article Published on:

  39. Patients with cancer of the lung or oesophagus, undergoing curative treatment, usually require a thoracotomy and a complex oncological resection. These surgeries carry a risk of major morbidity and mortality, ...

    Authors: Gráinne Sheill, Emer Guinan, Linda O’Neill, Charles Normand, Suzanne L. Doyle, Sarah Moore, John Newell, Grainne McDermott, Ronan Ryan, John V. Reynolds and Juliette Hussey
    Citation: BMC Cancer 2020 20:321
    Content type: Study protocol Published on:

  40. The aim of this systematic review and meta-analysis was to compare overall survival and disease-free survival after fertility sparing surgery (FSS) vs radical surgery in stage 1 epithelial ovarian cancer (EOC).

    Authors: Denghua Liu, Jing Cai, Aiwei Gao, Zehua Wang and Liqiong Cai
    Citation: BMC Cancer 2020 20:320
    Content type: Research article Published on:

  41. Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a promising intestinal stem cell and carcinoma stem cell marker. We examined the relationship between mismatch repair (MMR) protein deficie...

    Authors: Tomoyuki Nakajima, Takeshi Uehara, Mai Iwaya, Yukihiro Kobayashi, Yasuhiro Maruyama and Hiroyoshi Ota
    Citation: BMC Cancer 2020 20:319
    Content type: Research article Published on:

  42. Isocitrate dehydrogenase 1/2 (IDH1/2), BAP1, ARID1A and PBRM1 have been reported as the most frequent mutant genes in intrahepatic cholangiocarcinoma (ICC), and their relationships with clinicopathological fea...

    Authors: Bingqi Ma, Huijuan Meng, Ye Tian, Yingying Wang, Tianqiang Song, Ti Zhang, Qiang Wu, Yunlong Cui, Huikai Li, Wei Zhang and Qiang Li
    Citation: BMC Cancer 2020 20:318
    Content type: Research article Published on:

  43. Gastric cancer is a considerable burden for worldwide patients. And diffuse gastric cancer is the most insidious subgroup with poor survival. The phenotypic characterization of the diffuse gastric cancer cell ...

    Authors: Seon-Jin Yoon, Jungmin Park, Youngmin Shin, Yuna Choi, Sahng Wook Park, Seok-Gu Kang, Hye Young Son and Yong-Min Huh
    Citation: BMC Cancer 2020 20:314
    Content type: Research article Published on:

  45. Skin metastases from pancreatic neuroendocrine carcinoma (PNEC) are rare and their palliative treatment is challenging. We report our experience in the multimodal management of one of the few reported cases of...

    Authors: Maria Paola Ciliberti, Roberta Carbonara, Antonietta Grillo, Anna Maria Leo, Ivan Lolli, Carmela Ostuni, Laura Troiani, Barbara Turi, Simona Vallarelli and Angela Sardaro
    Citation: BMC Cancer 2020 20:311
    Content type: Case report Published on:

  46. Pancreatic cancer is a devastating disease with a dismal prognosis. Despite profound medical advances in systemic therapies for other types of aggressive tumours during recent years, a diagnosis of pancreatic ...

    Authors: Sofie Olsson Hau, Alexandra Petersson, Björn Nodin, Emelie Karnevi, Karolina Boman, Caroline Williamsson, Jakob Eberhard, Karin Leandersson, David Gisselsson, Margareta Heby and Karin Jirström
    Citation: BMC Cancer 2020 20:308
    Content type: Study protocol Published on:

  47. Metabolomics has a great potential in the development of new biomarkers in cancer and it has experiment recent technical advances.

    Authors: Lucía Trilla-Fuertes, Angelo Gámez-Pozo, Elena López-Camacho, Guillermo Prado-Vázquez, Andrea Zapater-Moros, Rocío López-Vacas, Jorge M. Arevalillo, Mariana Díaz-Almirón, Hilario Navarro, Paloma Maín, Enrique Espinosa, Pilar Zamora and Juan Ángel Fresno Vara
    Citation: BMC Cancer 2020 20:307
    Content type: Research article Published on:

  48. Gastrointestinal tract function and it’s integrity are controlled by a number of peptides whose secretion is influenced by severe inflammation. In stomach the main regulatory peptide is ghrelin. For upper smal...

    Authors: Szymon Skoczeń, Magdalena Rej, Kinga Kwiecińska, Danuta Pietrys, Przemysław J. Tomasik, Małgorzata Wójcik, Wojciech Strojny, Agnieszka Dłużniewska, Katarzyna Klimasz, Kamil Fijorek, Michał Korostyński, Marcin Piechota and Walentyna Balwierz
    Citation: BMC Cancer 2020 20:306
    Content type: Research article Published on:

  49. Colon adenocarcinoma (COAD) is one of the most lethal cancers. It is particularly important to accurately predict prognosis and to provide individualized treatment. Several lines of evidence suggest that genet...

    Authors: Xueying Li, Weiming Yu, Chao Liang, Yuan Xu, Miaozun Zhang, Xiaoyun Ding and Xianlei Cai
    Citation: BMC Cancer 2020 20:305
    Content type: Research article Published on:

  50. Although docetaxel-based chemohormonal therapy (CHT) is one of the standard treatments for castration-resistant prostate cancer (CRPC), pertinent biomarkers and precise mechanisms involved in the resistance fo...

    Authors: Yoshinori Matsuda, Shintaro Narita, Taketoshi Nara, Huang Mingguo, Hiromi Sato, Atsushi Koizumi, Sohei Kanda, Kazuyuki Numakura, Mitsuru Saito, Takamitsu Inoue, Yuko Hiroshima, Hiroshi Nanjo, Shigeru Satoh, Norihiko Tsuchiya and Tomonori Habuchi
    Citation: BMC Cancer 2020 20:302
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Follow

BMC Cancer

ISSN: 1471-2407

Contact us