American Cancer Society. Breast Cancer Facts & Figures 2017-2018. Atlanta: American Cancer Society, Inc.; 2017.
Gonzalez-Angulo AM, Litton JK, Broglio KR, et al. High risk of recurrence for patients with breast cancer who have human epidermal growth factor receptor 2-positive, node-negative tumors 1 cm or smaller. J Clin Oncol. 2009;27:5700–6.
Article
PubMed
PubMed Central
Google Scholar
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL. Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235:177–82.
Article
CAS
PubMed
Google Scholar
Ménard S, Pupa SM, Campiglio M, Tagliabue E. Biologic and therapeutic role of HER2 in cancer. Oncogene. 2003;22:6570–8.
Article
PubMed
CAS
Google Scholar
Nahta R, Esteva FJ. HER2 therapy: molecular mechanisms of trastuzumab resistance. Breast Cancer Res. 2006;8:215.
Article
PubMed
PubMed Central
CAS
Google Scholar
Klapper LN, Waterman H, Sela M, Yarden Y. Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing Ubiquitination of HER-2. Cancer Res. 2000;60:3384–8.
CAS
PubMed
Google Scholar
Sorace AG, Quarles CC, Whisenant JG, Hanker AB, McIntyre JO, Sanchez VM, Yankeelov TE. Trastuzumab improves tumor perfusion and vascular delivery of cytotoxic therapy in a murine model of HER2+ breast cancer: preliminary results. Breast Cancer Res Treat. 2016;155:273–84.
Article
CAS
PubMed
PubMed Central
Google Scholar
Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK. Tumour biology: Herceptin acts as an anti-angiogenic cocktail. Nature. 2002;416:279–80.
Article
CAS
PubMed
Google Scholar
Zhang A, Shen G, Zhao T, Zhang G, Liu J, Song L, Wei W, Bing L, Wu Z, Wu Q. Augmented inhibition of angiogenesis by combination of HER2 antibody chA21 and trastuzumab in human ovarian carcinoma xenograft. J Ovarian Res. 2010;3:20.
Article
PubMed
PubMed Central
CAS
Google Scholar
Klos KS, Zhou X, Lee S, Zhang L, Yang W, Nagata Y, Yu D. Combined trastuzumab and paclitaxel treatment better inhibits ErbB-2-mediated angiogenesis in breast carcinoma through a more effective inhibition of Akt than either treatment alone. Cancer. 2003;98:1377–85.
Article
CAS
PubMed
Google Scholar
Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J Clin Oncol. 2013;31:2205–18.
Article
CAS
PubMed
PubMed Central
Google Scholar
Goel S, Wong AH-K, Jain RK. Vascular normalization as a therapeutic strategy for malignant and nonmalignant disease. Cold Spring Harb Perspect Med. 2012. https://doi.org/10.1101/cshperspect.a006486.
Cortazar P, Zhang L, Untch M, et al. Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis. Lancet. 2014;384:164–72.
Article
PubMed
Google Scholar
Ebos JML, Kerbel RS. Antiangiogenic therapy: impact on invasion, disease progression, and metastasis. Nat Rev Clin Oncol. 2011;8:210–21.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gianni L, Romieu GH, Lichinitser M, et al. AVEREL: a randomized phase III trial evaluating bevacizumab in combination with docetaxel and trastuzumab as first-line therapy for HER2-positive locally recurrent/metastatic breast cancer. J Clin Oncol. 2013;31:1719–25.
Article
CAS
PubMed
Google Scholar
Research C for DE and (2019) Avastin (bevacizumab) information. FDA.
Anonymous. European medicines agency completes its review of Avastin used in breast cancer. In: European Medicines Agency; 2018. https://www.ema.europa.eu/en/news/european-medicines-agency-completes-its-review-avastin-used-breast-cancer. Accessed 17 Sep 2019.
Google Scholar
Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer. 2008;8:592–603.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rivera LB, Bergers G. Myeloid cell-driven angiogenesis and immune regulation in tumors. Trends Immunol. 2015;36:240–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schmid M, Varner JA. Myeloid cell trafficking and tumor angiogenesis. Cancer Lett. 2007;250:1–8.
Article
CAS
PubMed
Google Scholar
Murdoch C, Muthana M, Coffelt SB, Lewis CE. The role of myeloid cells in the promotion of tumour angiogenesis. Nat Rev Cancer. 2008;8:618–31.
Article
CAS
PubMed
Google Scholar
Jain RK. Normalization of tumor vasculature: An emerging concept in Antiangiogenic therapy. Science. 2005;307:58–62.
Article
CAS
PubMed
Google Scholar
Murdoch C, Giannoudis A, Lewis CE. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood. 2004;104:2224–34.
Article
CAS
PubMed
Google Scholar
Naldini A, Morena E, Pucci A, Miglietta D, Riboldi E, Sozzani S, Carraro F. Hypoxia affects dendritic cell survival: role of the hypoxia-inducible factor-1α and lipopolysaccharide. J Cell Physiol. 2012;227:587–95.
Article
CAS
PubMed
Google Scholar
Huang Y, Yuan J, Righi E, et al. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. PNAS. 2012;109:17561–6.
Article
CAS
PubMed
PubMed Central
Google Scholar
Rolny C, Mazzone M, Tugues S, et al. HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through Downregulation of PlGF. Cancer Cell. 2011;19:31–44.
Article
CAS
PubMed
Google Scholar
Tian X, Wei F, Wang L, Yu W, Zhang N, Zhang X, Han Y, Yu J, Ren X. Herceptin enhances the antitumor effect of natural killer cells on breast Cancer cells expressing human epidermal growth factor Receptor-2. Front Immunol. 2017. https://doi.org/10.3389/fimmu.2017.01426.
Arnould L, Gelly M, Penault-Llorca F, et al. Trastuzumab-based treatment of HER2-positive breast cancer: an antibody-dependent cellular cytotoxicity mechanism? Br J Cancer. 2006;94:259–67.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jarrett AM, Bloom MJ, Godfrey W, Syed AK, Ekrut DA, Ehrlich LI, Yankeelov TE, Sorace AG. Mathematical modelling of trastuzumab-induced immune response in an in vivo murine model of HER2+ breast cancer. Math Med Biol. https://doi.org/10.1093/imammb/dqy014.
De Palma M, Lewis CE. Macrophage regulation of tumor responses to anticancer therapies. Cancer Cell. 2013;23:277–86.
Article
PubMed
CAS
Google Scholar
Qian B, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell. 2010;141:39–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Movahedi K, Laoui D, Gysemans C, et al. Different tumor microenvironments contain functionally distinct subsets of macrophages derived from Ly6C(high) monocytes. Cancer Res. 2010;70:5728–39.
Article
CAS
PubMed
Google Scholar
Mantovani A, Sozzani S, Locati M, Allavena P, Sica A. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 2002;23:549–55.
Article
CAS
PubMed
Google Scholar
Jetten N, Verbruggen S, Gijbels MJ, Post MJ, De Winther MPJ, Donners MMPC. Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo. Angiogenesis. 2014;17:109–18.
Article
CAS
PubMed
Google Scholar
Kodelja V, Müller C, Tenorio S, Schebesch C, Orfanos CE, Goerdt S. Differences in angiogenic potential of classically vs alternatively activated macrophages. Immunobiology. 1997;197:478–93.
Article
CAS
PubMed
Google Scholar
Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 2010;11:889–96.
Article
CAS
PubMed
Google Scholar
Sun T, Yang Y, Luo X, Cheng Y, Zhang M, Wang K, Ge C. Inhibition of tumor angiogenesis by interferon-γ by suppression of tumor-associated macrophage differentiation. Oncol Res. 2014;21:227–35.
Article
CAS
PubMed
Google Scholar
Vangestel C, Van de Wiele C, Van Damme N, Staelens S, Pauwels P, Reutelingsperger CPM, Peeters M. (99)mTc-(CO)(3) his-annexin A5 micro-SPECT demonstrates increased cell death by irinotecan during the vascular normalization window caused by bevacizumab. J Nucl Med. 2011;52:1786–94.
Article
CAS
PubMed
Google Scholar
Amici SA, Young NA, Narvaez-Miranda J, Jablonski KA, Arcos J, Rosas L, Papenfuss TL, Torrelles JB, Jarjour WN, Guerau-de-Arellano M. CD38 is robustly induced in human macrophages and monocytes in inflammatory conditions. Front Immunol. 2018. https://doi.org/10.3389/fimmu.2018.01593.
Martinez FO, Helming L, Milde R, et al. Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences. Blood. 2013;121:e57–69.
Article
CAS
PubMed
Google Scholar
Huang Y, Goel S, Duda DG, Fukumura D, Jain RK. Vascular normalization as an emerging strategy to enhance Cancer immunotherapy. Cancer Res. 2013;73:2943–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Huang Y, Snuderl M, Jain RK. Polarization of tumor-associated macrophages: a novel strategy for vascular normalization and anti-tumor immunity. Cancer Cell. 2011;19:1–2.
Article
PubMed
PubMed Central
CAS
Google Scholar
Xuan W, Qu Q, Zheng B, Xiong S, Fan G-H. The chemotaxis of M1 and M2 macrophages is regulated by different chemokines. J Leukoc Biol. 2015;97:61–9.
Article
PubMed
CAS
Google Scholar
Liu Y, Cai Y, Liu L, Wu Y, Xiong X. Crucial biological functions of CCL7 in cancer. PeerJ. 2018. https://doi.org/10.7717/peerj.4928.
Räihä MR, Puolakkainen PA. Tumor-associated macrophages (TAMs) as biomarkers for gastric cancer: a review. Chronic Dis Transl Med. 2018;4:156–63.
Article
PubMed
PubMed Central
Google Scholar
Brown JM, Recht L, Strober S. The promise of targeting macrophages in Cancer therapy. Clin Cancer Res. 2017;23:3241–50.
Article
PubMed
PubMed Central
Google Scholar
Poh AR, Ernst M. Targeting macrophages in Cancer: from bench to bedside. Front Oncol. 2018. https://doi.org/10.3389/fonc.2018.00049.
Campbell MJ, Tonlaar NY, Garwood ER, et al. Proliferating macrophages associated with high grade, hormone receptor negative breast cancer and poor clinical outcome. Breast Cancer Res Treat. 2011;128:703–11.
Article
PubMed
Google Scholar
Feng Q, Chang W, Mao Y, et al. Tumor-associated macrophages as prognostic and predictive biomarkers for postoperative adjuvant chemotherapy in patients with stage II Colon Cancer. Clin Cancer Res. 2019;25:3896–907.
Article
PubMed
Google Scholar
Brana I, Calles A, LoRusso PM, Yee LK, Puchalski TA, Seetharam S, Zhong B, de Boer CJ, Tabernero J, Calvo E. Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study. Targ Oncol. 2015;10:111–23.
Article
Google Scholar
Gomez-Roca CA, Italiano A, Le Tourneau C, et al. Phase I study of emactuzumab single agent or in combination with paclitaxel in patients with advanced/metastatic solid tumors reveals depletion of immunosuppressive M2-like macrophages. Ann Oncol. 2019;30:1381–92.
Article
CAS
PubMed
PubMed Central
Google Scholar
Edwards JP, Emens LA. The multikinase inhibitor Sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE2 in murine macrophages. Int Immunopharmacol. 2010;10:1220–8.
Article
CAS
PubMed
PubMed Central
Google Scholar
Georgoudaki A-M, Prokopec KE, Boura VF, et al. Reprogramming tumor-associated macrophages by antibody targeting inhibits Cancer progression and metastasis. Cell Rep. 2016;15:2000–11.
Article
CAS
PubMed
Google Scholar
Deng Y-R, Liu W-B, Lian Z-X, Li X, Hou X. Sorafenib inhibits macrophage-mediated epithelial-mesenchymal transition in hepatocellular carcinoma. Oncotarget. 2016;7:38292–305.
PubMed
PubMed Central
Google Scholar
Shi Y, Fan X, Deng H, Brezski RJ, Rycyzyn M, Jordan RE, Strohl WR, Zou Q, Zhang N, An Z. Trastuzumab triggers phagocytic killing of high HER2 Cancer cells in vitro and in vivo by interaction with Fcγ receptors on macrophages. J Immunol. 2015;194:4379–86.
Article
CAS
PubMed
Google Scholar
Jablonski KA, Amici SA, Webb LM, de Ruiz-Rosado Juan D, Popovich PG, Partida-Sanchez S, Guerau-de-Arellano M. Novel markers to delineate murine M1 and M2 macrophages. PLoS One. 2015. https://doi.org/10.1371/journal.pone.0145342.
Orecchioni M, Ghosheh Y, Pramod AB, Ley K. Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS–) vs. alternatively activated macrophages. Front Immunol. 2019. https://doi.org/10.3389/fimmu.2019.01084.