Lin ME, Herr DR, Chun J. Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance. Prostaglandins Other Lipid Mediat. 2010;91(3-4):130–8.
Article
PubMed
CAS
Google Scholar
Ishii I, Fukushima N, Ye X, Chun J. Lysophospholipid receptors: signaling and biology. Annu Rev Biochem. 2004;73:321–54.
Article
PubMed
CAS
Google Scholar
Yung YC, Stoddard NC, Chun J. LPA receptor signaling: pharmacology, physiology, and pathophysiology. J Lipid Res. 2014;55(7):1192–214.
Article
PubMed
PubMed Central
CAS
Google Scholar
Hwang SH, Yeom H, Eom SY, Lee YM, Lee M. Genome-wide DNA methylation changes in transformed foci induced by nongenotoxic carcinogens. Environ Mol Mutagen. 2019;60(7):576–87.
PubMed
CAS
Google Scholar
Hama K, Aoki J. LPA(3), a unique G protein-coupled receptor for lysophosphatidic acid. Prog Lipid Res. 2010;49(4):335–42.
Article
PubMed
CAS
Google Scholar
Tanabe E, Kitayoshi M, Yoshikawa K, Shibata A, Honoki K, Fukushima N, et al. Loss of lysophosphatidic acid receptor-3 suppresses cell migration activity of human sarcoma cells. J Recept Signal Transduct Res. 2012;32(6):328–34.
Article
PubMed
CAS
Google Scholar
Yu S, Murph MM, Lu Y, Liu S, Hall HS, Liu J, et al. Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. J Natl Cancer Inst. 2008;100(22):1630–42.
Article
PubMed
PubMed Central
CAS
Google Scholar
Cai H, Xu Y. The role of LPA and YAP signaling in long-term migration of human ovarian cancer cells. Cell Commun Signal. 2013;11(1):e31.
Article
CAS
Google Scholar
Okabe K, Hayashi M, Kato K, Okumura M, Fukui R, Honoki K, et al. Lysophosphatidic acid receptor-3 increases tumorigenicity and aggressiveness of rat hepatoma RH7777 cells. Mol Carcinog. 2013;52(4):247–54.
Article
PubMed
CAS
Google Scholar
Fukui R, Tanabe E, Kitayoshi M, Yoshikawa K, Fukushima N, Tsujiuchi T. Negative regulation of cell motile and invasive activities by lysophosphatidic acid receptor-3 in colon cancer HCT116 cells. Tumour Biol. 2012;33(6):1899–905.
Article
PubMed
CAS
Google Scholar
Hayashi M, Okabe K, Yamawaki Y, Teranishi M, Honoki K, Mori T, et al. Loss of lysophosphatidic acid receptor-3 enhances cell migration in rat lung tumor cells. Biochem Biophys Res Commun. 2011;405(3):450–4.
Article
PubMed
CAS
Google Scholar
Furui T, LaPushin R, Mao M, Khan H, Watt SR, Watt MA, et al. Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner. Clin Cancer Res. 1999;5(12):4308–18.
PubMed
CAS
Google Scholar
Tsujino M, Fujii M, Okabe K, Mori T, Fukushima N, Tsujiuchi T. Differential expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in human colon cancer cells. Virchows Arch. 2010;457(6):669–76.
Article
PubMed
CAS
Google Scholar
Okabe K, Hayashi M, Wakabayash IN, Yamawaki Y, Teranishi M, Fukushima N, et al. Different expressions and DNA methylation patterns of lysophosphatidic acid receptor genes in mouse tumor cells. Pathobiology. 2010;77(6):309–14.
Article
PubMed
CAS
Google Scholar
Pan Y, Liu G, Zhou F, Su B, Li Y. DNA methylation profiles in cancer diagnosis and therapeutics. Clin Exp Med. 2018;18(1):1–14.
Article
PubMed
CAS
Google Scholar
Jones PA. Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet. 2012;13(7):484–92.
Article
PubMed
CAS
Google Scholar
Sasaki K, Umeda M, Sakai A, Yamazaki S, Tanaka N. Transformation assay in Bhas 42 cells: a model using initiated cells to study mechanisms of carcinogenesis and predict carcinogenic potential of chemicals. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2015;33(1):1–35.
Article
PubMed
CAS
Google Scholar
Lee M, Ahn J-H, K.-H. E. The difference in biological properties between parental and v-ha-ras transformed NIH3T3 cells. Cancer Res Treat. 2009;41(2):93–9.
Article
PubMed
PubMed Central
Google Scholar
Yeom H, Hwang SH, Kim H-G, Lee M. Increase in the sensitivity to PLX4720 through inhibition of transcription factor EB-dependent autophagy in BRAF inhibitor-resistant cells. Toxciol Res. 2022;38(1):35–44.
Article
CAS
Google Scholar
Hwang SH, Han B-I, Lee M. Knockout of ATG5 leads to malignant cell transformation and resistance to Src family kinase inhibitor PP2. J Cell Physiol. 2018;233(1):506–15.
Article
PubMed
CAS
Google Scholar
Ahn J-H, Park SN, Yum Y-N, Kim J-Y, Lee M. Comparison of in vitro cell transformation assay using murine fibroblasts and human keratinocytes. Toxicol Sci. 2008;24(1):37–44.
Article
CAS
Google Scholar
Kajiwara Y, Ajimi S. Verification of the BALB/c 3T3 cell transformation assay after improvement by using an ITES-medium. Toxicol in Vitro. 2003;17(4):489–96.
Article
PubMed
CAS
Google Scholar
Geback T, Schulz MM, Koumoutsakos P, Detmar M. TScratch: a novel and simple software tool for automated analysis of monolayer wound healing assays. Biotechniques. 2009;46(4):265–74.
Article
PubMed
CAS
Google Scholar
Kim J-H, Ahn J-H, Lee M. Upregulation of microRNA-1246 is associated with BRAF inhibitor resistance in melanoma cells with mutant BRAF. Cancer Res Treat. 2017;49(4):947–59.
Article
PubMed
PubMed Central
CAS
Google Scholar
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)). Method Methods. 2001;25:402–8.
Article
PubMed
CAS
Google Scholar
Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349(21):2042–54.
Article
PubMed
CAS
Google Scholar
Kröger C, Afeyan A, Mraz J, Eaton EN, Reinhardt F, Khodor YL, et al. Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells. Proc Natl Acad Sci U S A. 2019;116(15):7353–62.
Article
PubMed
PubMed Central
CAS
Google Scholar
Ishii I, Contos JJ, Fukushima N, Chun J. Functional comparisons of the lysophosphatidic acid receptors, LP(A1)/VZG-1/EDG-2, LP(A2)/EDG-4, and LP(A3)/EDG-7 in neuronal cell lines using a retrovirus expression system. Mol Pharmacol. 2000;58(5):895–902.
Article
PubMed
CAS
Google Scholar
Colhado Rodrigues BL, Lallo MA, Perez EC. The controversial role of autophagy in tumor development: a systematic review. Immunol Investig. 2020;49(4):386–96.
Article
CAS
Google Scholar
Yang J, Xu J, Han X, Wang H, Zhang Y, Dong J, et al. Lysophosphatidic acid is associated with cardiac dysfunction and hypertrophy by suppressing autophagy via the LPA3/AKT/mTOR pathway. Front Physiol. 2018;18(9):1315.
Article
Google Scholar
Zhang Z, Singh R, Aschner M. Methods for the detection of autophagy in mammalian cells. Curr Protoc Toxicol. 2016;69:20.12.21–6.
Article
Google Scholar
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011;25(5):460–70.
Article
PubMed
PubMed Central
CAS
Google Scholar
Su Y, Qian H, Zhang J, Wang S, Shi P, X. P. The diversity expression of p62 in digestive system cancers. Clin Immunol. 2005;116(2):118–23.
Article
PubMed
CAS
Google Scholar
Schmukler E, Kloog Y, Pinkas-Kramarski R. Ras and autophagy in cancer development and therapy. Oncotarget. 2014;5(3):577–86.
Article
PubMed
PubMed Central
Google Scholar
Chappell WH, Steelman LS, Long JM, Kempf RC, Abrams SL, Franklin RA, et al. Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health. Oncotarget. 2011;2(3):135–64.
Article
PubMed
PubMed Central
Google Scholar
Fang X, Gaudette D, Furui T, Mao M, Estrella V, Eder A, et al. Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer. Ann N Y Acad Sci. 2000;905:188–208.
Article
PubMed
CAS
Google Scholar
Fukushima K, Takahashi K, Yamasaki E, Onishi Y, Fukushima N, Honoki K, et al. Lysophosphatidic acid signaling via LPA 1 and LPA 3 regulates cellular functions during tumor progression in pancreatic cancer cells. Exp Cell Res. 2017;352(1):139–45.
Article
PubMed
CAS
Google Scholar
Ueda N, Minami K, Ishimoto K, Tsujiuchi T. Effects of lysophosphatidic acid (LPA) receptor-2 (LPA2) and LPA3 on the regulation of chemoresistance to anticancer drug in lung cancer cells. Cell Signal. 2020;69:109551.
Article
PubMed
CAS
Google Scholar
Jia W, Tran SK, Ruddick CA, Murph MM. The Src homology 3 binding domain is required for lysophosphatidic acid 3 receptor-mediated cellular viability in melanoma cells. Cancer Lett. 2015;356(2 Pt B):589–96.
Article
PubMed
CAS
Google Scholar
Singh SS, Vats S, Chia AY, Tan TZ, Deng S, Ong MS, et al. Dual role of autophagy in hallmarks of cancer. Oncogene. 2018;37(9):1142–58.
Article
PubMed
CAS
Google Scholar
Button RW, Roberts SL, Willis TL, Hanemann CO, Luo S. Accumulation of autophagosomes confers cytotoxicity. J Biol Chem. 2017;292(33):13599–614.
Article
PubMed
PubMed Central
CAS
Google Scholar
Perera RM, Stoykova S, Nicolay BN, Ross KN, Fitamant J, Boukhali M, et al. Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism. Nature. 2015;524(7565):361–5.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zuckerman V, Sokolov E, Swet JH, Ahrens WA, Showlater V, Iannitti DA, et al. Expression and function of lysophosphatidic acid receptors (LPARs) 1 and 3 in human hepatic cancer progenitor cells. Oncotarget. 2016;7(3):2951–67.
Article
PubMed
Google Scholar
Choi JW, Herr DR, Noguchi K, Yung YC, Lee C-W, Mutoh T, et al. LPA receptors: subtypes and biological actions. Annu Rev Pharamcol Toxicol. 2010;50:157–86.
Article
CAS
Google Scholar
Xiang XY, Yang XC, Su J, Kang JS, Wu Y, Xue YN, et al. Inhibition of autophagic flux by ROS promotes apoptosis during DTT-induced ER/oxidative stress in HeLa cells. Oncol Rep. 2016;35(6):3471–9.
Article
PubMed
CAS
Google Scholar
Luo S, Rubinsztein DC. Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL. Cell Death Differ. 2010;17(2):268–77.
Article
PubMed
CAS
Google Scholar
Wirawan E, Vande Walle L, Kersse K, Cornelis S, Claerhout S, Vanoverberghe I, et al. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis. 2010;1(1):e18.
Article
PubMed
PubMed Central
CAS
Google Scholar