Kadota K, Nitadori J, Sima CS, Ujiie H, Rizk NP, Jones DR, Adusumilli PS, Travis WD. Tumor spread through air spaces is an important pattern of invasion and impacts the frequency and location of recurrences after limited resection for small stage I lung adenocarcinomas. J Thorac Oncol. 2015;10:806–14.
Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG. WHO classification of Tumours of the lung, pleura, Thymus and heart. 4th ed. Lyon: IARC Press; 2015.
Rami-Porta R, Bolejack V, Crowley J, Ball D, Kim J, Lyons G, Rice T, Suzuki K, Thomas CF Jr, Travis WD, Wu YL. The IASLC lung Cancer staging project: proposals for the revisions of the T descriptors in the forthcoming eighth edition of the TNM classification for lung Cancer. J Thorac Oncol. 2015;10:990–1003.
Sun PL, Jin Y, Kim H, Seo AN, Jheon S, Lee CT, Chung JH. Survivin expression is an independent poor prognostic marker in lung adenocarcinoma but not in squamous cell carcinoma. Virchows Arch. 2013;463:427–36.
Kim H, Yoo SB, Choe JY, Paik JH, Xu X, Nitta H, Zhang W, Grogan TM, Lee CT, Jheon S, Chung JH. Detection of ALK gene rearrangement in non-small cell lung cancer: a comparison of fluorescence in situ hybridization and chromogenic in situ hybridization with correlation of ALK protein expression. J Thorac Oncol. 2011;6:1359–66.
Jin Y, Sun PL, Park SY, Kim H, Park E, Kim G, Cho S, Kim K, Lee CT, Chung JH. Frequent aerogenous spread with decreased E-cadherin expression of ROS1-rearranged lung cancer predicts poor disease-free survival. Lung Cancer. 2015;89:343–9.
Hu SY, Hsieh MS, Hsu HH, Tsai TM, Chiang XH, Tsou KC, Liao HC, Lin MW, Chen JS. Correlation of tumor spread through air spaces and clinicopathological characteristics in surgically resected lung adenocarcinomas. Lung Cancer. 2018;126:189–93.
Liu Y, Chen D, Qiu X, Duan S, Zhang Y, Li F, Chen C, Zhou Y, Chen Y. Relationship between MTA1 and spread through air space and their joint influence on prognosis of patients with stage I-III lung adenocarcinoma. Lung Cancer. 2018;124:211–8.
Yang L, Yang Y, Ma P, Zheng B, Liu W, Zhang Z, Ding N, Liu L, Mao Y, Lv N. Spread through air spaces predicts a worse survival in patients with stage I adenocarcinomas >2 cm after radical lobectomy. J Thorac Dis. 2018;10:5308–17.
Bains S, Eguchi T, Warth A, Yeh YC, Nitadori JI, Woo KM, Chou TY, Dienemann H, Muley T, Nakajima J, Shinozaki-Ushiku A, Wu YC, Lu S, Kadota K, Jones DR, Travis WD, Tan KS, Adusumilli PS. Procedure-specific risk prediction for recurrence in patients undergoing lobectomy or sublobar resection for small (</=2 cm) lung adenocarcinoma: an international cohort analysis. J Thorac Oncol. 2019;14:72–86.
Eguchi T, Kameda K, Lu S, Bott MJ, Tan KS, Montecalvo J, Chang JC, Rekhtman N, Jones DR, Travis WD, Adusumilli PS. Lobectomy is associated with better outcomes than sublobar resection in spread through air spaces (STAS)-positive T1 lung adenocarcinoma: a propensity score-matched analysis. J Thorac Oncol. 2019;14:87–98.
Kadota K, Kushida Y, Kagawa S, Ishikawa R, Ibuki E, Inoue K, Go T, Yokomise H, Ishii T, Kadowaki N, Haba R. Limited resection is associated with a higher risk of Locoregional recurrence than lobectomy in stage I lung adenocarcinoma with tumor spread through air spaces. Am J Surg Pathol. 2019;43:1033–41.
Qiu X, Chen D, Liu Y, Duan S, Zhang F, Zhang Y, Li F, Chen C, Chen Y. Relationship between stromal cells and tumor spread through air spaces in lung adenocarcinoma. Thorac Cancer. 2019;10:256–67.
Ren Y, Xie H, Dai C, She Y, Su H, Xie D, Zheng H, Zhang L, Jiang G, Wu C, Chen C. Prognostic impact of tumor spread through air spaces in sublobar resection for 1A lung adenocarcinoma patients. Ann Surg Oncol. 2019;26:1901–8.
Terada Y, Takahashi T, Morita S, Kashiwabara K, Nagayama K, Nitadori JI, Anraku M, Sato M, Shinozaki-Ushiku A, Nakajima J. Spread through air spaces is an independent predictor of recurrence in stage III (N2) lung adenocarcinoma. Interact Cardiovasc Thorac Surg. 2019;29:442–8.
Yanagawa N, Shiono S, Endo M, Ogata SY. Tumor spread through air spaces is a useful predictor of recurrence and prognosis in stage I lung squamous cell carcinoma, but not in stage II and III. Lung Cancer. 2018;120:14–21.
Kadota K, Kushida Y, Katsuki N, Ishikawa R, Ibuki E, Motoyama M, Nii K, Yokomise H, Bandoh S, Haba R. Tumor spread through air spaces is an independent predictor of recurrence-free survival in patients with resected lung squamous cell carcinoma. Am J Surg Pathol. 2017;41:1077–86.
Lu S, Tan KS, Kadota K, Eguchi T, Bains S, Rekhtman N, Adusumilli PS, Travis WD. Spread through air spaces (STAS) is an independent predictor of recurrence and lung Cancer-specific death in squamous cell carcinoma. J Thorac Oncol. 2017;12:223–34.
Warth A, Muley T, Kossakowski CA, Goeppert B, Schirmacher P, Dienemann H, Weichert W. Prognostic impact of intra-alveolar tumor spread in pulmonary adenocarcinoma. Am J Surg Pathol. 2015;39:793–801.
Lee JS, Kim EK, Kim M, Shim HS. Genetic and clinicopathologic characteristics of lung adenocarcinoma with tumor spread through air spaces. Lung Cancer. 2018;123:121–6.
Kim SK, Kim TJ. Lung adenocarcinoma: CT features associated with spread through air spaces. Radiology. 2018;289:831–40.
Toyokawa G, Yamada Y, Tagawa T, Kinoshita F, Kozuma Y, Matsubara T, Haratake N, Takamori S, Akamine T, Hirai F, Oda Y, Maehara Y. Significance of spread through air spaces in resected lung adenocarcinomas with lymph node metastasis. Clin Lung Cancer. 2018;19:395–400 e1.
Toyokawa G, Yamada Y, Tagawa T, Kozuma Y, Matsubara T, Haratake N, Takamori S, Akamine T, Oda Y, Maehara Y. Significance of spread through air spaces in resected pathological stage I lung adenocarcinoma. Ann Thorac Surg. 2018;105:1655–63.
Toyokawa G, Yamada Y, Tagawa T, Oda Y. Significance of spread through air spaces in early-stage lung adenocarcinomas undergoing limited resection. Thorac Cancer. 2018;9:1255–61.
Kim J, Jang SJ, Choi CM, Ro JY. Correlation of histologic subtypes and molecular alterations in pulmonary adenocarcinoma: therapeutic and prognostic implications. Adv Anat Pathol. 2016;23:330–8.
Masai K, Sakurai H, Sukeda A, Suzuki S, Asakura K, Nakagawa K, Asamura H, Watanabe SI, Motoi N, Hiraoka N. Prognostic impact of margin distance and tumor spread through air spaces in limited resection for primary lung Cancer. J Thorac Oncol. 2017;12:1788–97.
Tsoukalas N, Aravantinou-Fatorou E, Tolia M, Giaginis C, Galanopoulos M, Kiakou M, Kostakis ID, Dana E, Vamvakaris I, Korogiannos A, Tsiambas E, Salemis N, Kyrgias G, Karameris A, Theocharis S. Epithelial-Mesenchymal transition in non small-cell lung Cancer. Anticancer Res. 2017;37:1773–8.
Yagi Y, Aly R, Tabata K, Rekhtman N, Eguchi T, Montecalvo J, Manova K, Adusumilli P, Hameed M, Travis W. OA03.07 Three-Dimensional Immunofluorescence Analysis of Dynamic Vessel Co-Option of Spread Through Air Spaces (STAS) in Lung Cancer. J Thorac Oncol. 2018;13:S327.