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Table 3 Correlations between immunohistochemical expression and STAS

From: Comprehensive analysis of spread through air spaces in lung adenocarcinoma and squamous cell carcinoma using the 8th edition AJCC/UICC staging system

Antibodies In total STAS in ADC p In total STAS in SQCC p
Positive(n(%)) Negative(n(%)) Positive(n(%)) Negative(n(%))
E-cadherin
 Low 171 119(66.9) 52(47.3) 0.001 32 16(41.0) 16(19.5) 0.012
 High 117 59(33.1) 58(52.7) 89 23(59.0) 66(80.5)
Vimentin
 Low 143 76(42.7) 67(60.9) 0.003 54 12(30.8) 42(51.2) 0.034
 High 145 102(57.3) 43(39.1) 67 27(69.2) 40(48.8)
Survivin
 Low 113 67(37.6) 46(41.8) 0.481 77 15(38.5) 62(75.6) < 0.001
 High 175 111(62.4) 64(58.2) 44 24(61.5) 20(24.4)
Ki67
 Low 125 62(34.8) 63(57.3) < 0.001 59 22(56.4) 37(45.1) 0.246
 High 163 116(65.2) 47(42.7) 62 17(43.6) 45(54.9)
Bcl-2
 Low 115 76(42.7) 39(35.5) 0.223 71 22(56.4) 49(59.8) 0.727
 High 173 102(57.3) 71(64.5) 50 17(43.6) 33(40.2)
Bim
 Low 135 87(48.9) 48(43.6) 0.387 61 23(59.0) 38(46.3) 0.194
 High 153 91(51.1) 62(56.4) 60 16(41.0) 44(53.7)
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