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Table 2 Correlations between clinicopathological parameters and STAS in SQCC

From: Comprehensive analysis of spread through air spaces in lung adenocarcinoma and squamous cell carcinoma using the 8th edition AJCC/UICC staging system

Parameters In total STAS p
Positive(n(%)) Negative(n(%))
In total 121 39(32.2) 82(67.8)  
Gender
 Female 2 0(0) 2(2.4) 1.000
 Male 119 39(100.0) 80(97.6)
Age
  ≤ 65 38 15(38.5) 23(28.0) 0.249
  > 65 83 24(61.5) 59(72.0)
Smoking history
 Non-smoker 6 0(0) 6(7.3) 0.175
 Smoker 115 39(100.0) 76(92.7)
Tumor size
  ≤ 3 cm 37 12(30.8) 25(30.5) 0.975
  > 3 cm 84 27(69.2) 57(69.5)
Pleural invasion
 Absent 82 28(71.8) 54(65.9) 0.513
 Present 39 11(28.2) 28(34.1)
Vascular invasion
 Absent 89 25(64.1) 64(78.0) 0.104
 Present 32 14(35.9) 18(22.0)
Lymphatic invasion
 Absent 68 16(41.0) 52(63.4) 0.020
 Present 53 23(59.0) 30(36.6)
Perineural invasion
 Absent 103 30(76.9) 73(89.0) 0.080
 Present 18 9(23.1) 9(11.0)
Tumor necrosis
 Absent 12 3(7.7) 9(11.0) 0.750
 Present 109 36(92.3) 73(89.0)
Tumor relapse
 Absent 89 29(74.4) 60(73.2) 0.890
 Present 32 10(25.6) 22(26.8)
Pathological stage
 Stage I-II 89 26(66.7) 63(76.8) 0.236*
 StageIA 28 8(20.5) 20(24.4) 0.443
 StageIB 21 4(10.3) 17(20.7)
 StageIIA 26 11(28.2) 15(18.3) 0.299
 StageIIB 14 3(7.7) 11(13.4)
 Stage III-IV 32 13(33.3) 19(23.2)  
  1. *Correlation between stage I-II and stage III-IV