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Table 2 Correlations between clinicopathological parameters and STAS in SQCC

From: Comprehensive analysis of spread through air spaces in lung adenocarcinoma and squamous cell carcinoma using the 8th edition AJCC/UICC staging system

Parameters

In total

STAS

p

Positive(n(%))

Negative(n(%))

In total

121

39(32.2)

82(67.8)

 

Gender

 Female

2

0(0)

2(2.4)

1.000

 Male

119

39(100.0)

80(97.6)

Age

  ≤ 65

38

15(38.5)

23(28.0)

0.249

  > 65

83

24(61.5)

59(72.0)

Smoking history

 Non-smoker

6

0(0)

6(7.3)

0.175

 Smoker

115

39(100.0)

76(92.7)

Tumor size

  ≤ 3 cm

37

12(30.8)

25(30.5)

0.975

  > 3 cm

84

27(69.2)

57(69.5)

Pleural invasion

 Absent

82

28(71.8)

54(65.9)

0.513

 Present

39

11(28.2)

28(34.1)

Vascular invasion

 Absent

89

25(64.1)

64(78.0)

0.104

 Present

32

14(35.9)

18(22.0)

Lymphatic invasion

 Absent

68

16(41.0)

52(63.4)

0.020

 Present

53

23(59.0)

30(36.6)

Perineural invasion

 Absent

103

30(76.9)

73(89.0)

0.080

 Present

18

9(23.1)

9(11.0)

Tumor necrosis

 Absent

12

3(7.7)

9(11.0)

0.750

 Present

109

36(92.3)

73(89.0)

Tumor relapse

 Absent

89

29(74.4)

60(73.2)

0.890

 Present

32

10(25.6)

22(26.8)

Pathological stage

 Stage I-II

89

26(66.7)

63(76.8)

0.236*

 StageIA

28

8(20.5)

20(24.4)

0.443

 StageIB

21

4(10.3)

17(20.7)

 StageIIA

26

11(28.2)

15(18.3)

0.299

 StageIIB

14

3(7.7)

11(13.4)

 Stage III-IV

32

13(33.3)

19(23.2)

 
  1. *Correlation between stage I-II and stage III-IV