Table 1 Correlations between clinicopathological parameters and STAS in ADC
Parameters | In total | STAS | p | |
|---|---|---|---|---|
Positive(n(%)) | Negative(n(%)) | |||
In total | 303 | 183(60.4) | 120(39.6) | Â |
Gender | ||||
 Female | 153 | 91(49.7) | 62(51.7) | 0.741 |
 Male | 150 | 92(50.3) | 58(48.3) | |
Age | ||||
  ≤ 65 | 157 | 91(49.7) | 66(55.0) | 0.369 |
  > 65 | 146 | 92(50.3) | 54(45.0) | |
Smoking history | ||||
 Non-smoker | 183 | 112(61.2) | 71(59.2) | 0.723 |
 Smoker | 120 | 71(38.8) | 49(40.8) | |
Tumor size | ||||
  ≤ 3 cm | 177 | 94(51.4) | 83(69.2) | 0.002 |
  > 3 cm | 126 | 89(48.6) | 37(30.8) | |
Predominant subtype | ||||
 Acinar | 154 | 89(48.6) | 65(54.2) | 0.104 |
 Papillary | 82 | 54(29.5) | 28(23.3) | |
 Lepidic | 45 | 27(14.8) | 18(15.0) | |
 Solid | 6 | 1(0.5) | 5(4.2) | |
 Micropapillary | 16 | 12(6.6) | 4(3.3) | |
Presence of micropapillary | ||||
 Absent | 229 | 115(62.8) | 114(95.0) | < 0.001 |
 Present | 74 | 68(37.2) | 6(5.0) | |
Pleural invasion | ||||
 Absent | 168 | 93(50.8) | 75(62.5) | 0.045 |
 Present | 135 | 90(49.2) | 45(37.5) | |
Vascular invasion | ||||
 Absent | 189 | 92(50.3) | 97(80.8) | < 0.001 |
 Present | 114 | 91(49.7) | 23(19.2) | |
Lymphatic invasion | ||||
 Absent | 148 | 58(31.7) | 90(75.0) | < 0.001 |
 Present | 155 | 125(68.3) | 30(25.0) | |
Perineural invasion | ||||
 Absent | 280 | 163(89.1) | 117(97.5) | 0.007 |
 Present | 23 | 20(10.9) | 3(2.5) | |
Tumor necrosis | ||||
 Absent | 196 | 103(56.3) | 93(77.5) | < 0.001 |
 Present | 107 | 80(43.7) | 27(22.5) | |
Tumor relapse | ||||
 Absent | 212 | 110(60.1) | 102(85.0) | < 0.001 |
 Present | 91 | 73(39.9) | 18(15.0) | |
Pathological stage | ||||
 Stage I-II | 230 | 128(69.9) | 102(85.0) | 0.003* |
 StageIA | 86 | 39(21.3) | 47(39.2) | 0.111 |
 StageIB | 87 | 50(27.3) | 37(30.8) | |
 StageIIA | 46 | 29(15.8) | 17(14.2) | 0.146 |
 StageIIB | 11 | 10(5.5) | 1(0.8) | |
 Stage III-IV | 73 | 55(30.1) | 18(15.0) |  |
EGFR mutation | ||||
 Negative | 143 | 96(52.5) | 47(39.2) | 0.023 |
 Positive | 160 | 87(47.5) | 73(60.8) | |
KRAS mutation | ||||
 Negative | 243 | 148(91.9) | 95(96.0) | 0.201 |
 Positive | 17 | 13(8.1) | 4(4.0) | |
ALK rearrangement | ||||
 Negative | 279 | 160(87.4) | 119(99.2) | < 0.001 |
 Positive | 24 | 23(12.6) | 1(0.8) | |
ROS1 rearrangement | ||||
 Negative | 294 | 174(95.1) | 120(100.0) | 0.013 |
 Positive | 9 | 9(4.9) | 0(0) | |