Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29.
Article
PubMed
Google Scholar
Follen M, Levenback CF, Iyer RB, Grigsby PW, Boss EA, Delpassand ES, et al. Imaging in cervical cancer. Cancer. 2003;98:2028–38.
Article
PubMed
Google Scholar
Bell MC, Alvarez RD. Chemoprevention and vaccines: a review of the nonsurgical options for the treatment of cervical dysplasia. Int J Gynecol Cancer Blackwell Science Inc. 2005;15:4–12.
Article
CAS
Google Scholar
Hazra B, Ghosh S, Kumar A, Pandey BN. The prospective role of plant products in radiotherapy of cancer: a current overview. Front Pharmacol. 2011;2:94.
PubMed
Google Scholar
Ojeda MO, van’t Veer C, Fernández Ortega CB, Araña Rosainz Mde J, Buurman WA. Dialyzable leukocyte extract differentially regulates the production of TNFalpha, IL-6, and IL-8 in bacterial component-activated leukocytes and endothelial cells. Inflamm Res. 2005;54:74–81.
Article
CAS
PubMed
Google Scholar
Franco-Molina MA, Mendoza-Gamboa E, Miranda-Hernández D, Zapata-Benavides P, Castillo-León L, Isaza-Brando C, et al. In vitro effects of bovine dialyzable leukocyte extract (bDLE) in cancer cells. Cytotherapy. 2006;8:408–14.
Article
CAS
PubMed
Google Scholar
PEREZ-TAPIA SM, LOPEZ-ISLAS I, FUENTE-GRANADA MDLA, ARRATIA-VALDELAMAR K, JIMENEZ-GALLEGOS N, RODRIGUEZ-FLORES A, et al. Use of dialyzable leukocyte extracts (DLE) in patients with severe sepsis (49.35). J Immunol. 2007;178:S90.
Google Scholar
Mendoza-Gamboa E, Franco-Molina MA, Zapata-Benavides P, Castillo-Tello P, Vera-García ME, Tamez-Guerra RS, et al. Bovine dialyzable leukocyte extract modulates AP-1 DNA-binding activity and nuclear transcription factor expression in MCF-7 breast cancer cells. Cytotherapy. 2008;10:212–9.
Article
CAS
PubMed
Google Scholar
Lara HH, Ixtepan-Turrent L, Garza-Treviño EN, Tamez-Guerra R, Rodriguez-Padilla C. Clinical and immunological assessment in breast cancer patients receiving anticancer therapy and bovine dialyzable leukocyte extract as an adjuvant. Exp Ther Med Spandidos Publications. 2010;1:425–31.
Article
CAS
Google Scholar
Franco-Molina MA, Mendoza-Gamboa E, Zapata-Benavides P, Castillo-Tello P, Isaza-Brando CE, Zamora-Avila D, et al. Antiangiogenic and antitumor effects of IMMUNEPOTENT CRP in murine melanoma. Immunopharmacol Immunotoxicol. 2010;32:637–46.
Article
CAS
PubMed
Google Scholar
Coronado-Cerda EE, Franco-Molina MA, Mendoza-Gamboa E, Prado-García H, Rivera-Morales LG, Zapata-Benavides P, et al. In Vivo Chemoprotective activity of bovine dialyzable leukocyte extract in mouse bone marrow cells against damage induced by 5-fluorouracil. J Immunol Res Hindawi Publishing Corporation. 2016;2016:1–10.
Google Scholar
Arnaudov A, Kostova Z. Dialysable leukocyte extracts in immunotherapy. Med. Biotechnol: Taylor & Francis; 2015.
Google Scholar
Martinez-Torres A-C, Quiney C, Attout T, Boullet H, Herbi L, Vela L, et al. CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans. PLoS Med. 2015;12:e1001796.
Article
PubMed
PubMed Central
Google Scholar
Liu Y, Dai H, Xiao W. UAS(MAG1), a yeast cis-acting element that regulates the expression of MAG1, is located within the protein coding region of DDI1. Mol Gen Genet. 1997;255:533–42.
Article
CAS
PubMed
Google Scholar
Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, et al. Classification of cell death: recommendations of the nomenclature committee on cell death 2009. Cell Death Differ. 2009;16:3–11.
Article
CAS
PubMed
Google Scholar
Thomadaki H, Tsiapalis CM, Scorilas A. Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction. Biol Chem. 2005;386(5):471–80.
Article
CAS
PubMed
Google Scholar
Leist M, Jäättelä M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev Mol Cell Biol Nature Publishing Group. 2001;2:589–98.
Article
CAS
Google Scholar
Toné S, Sugimoto K, Tanda K, Suda T, Uehira K, Kanouchi H, et al. Three distinct stages of apoptotic nuclear condensation revealed by time-lapse imaging, biochemical and electron microscopy analysis of cell-free apoptosis. Exp Cell Res. 2007;313:3635–44.
Article
PubMed
PubMed Central
Google Scholar
Caserta TM, Smith AN, Gultice AD, Reedy MA, Brown TL. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis. 2003;8:345–52.
Article
CAS
PubMed
Google Scholar
Vakifahmetoglu-Norberg H, Ouchida AT, Norberg E. The role of mitochondria in metabolism and cell death. Biochem Biophys Res Commun. 2017;482(3):426–31.
Article
CAS
PubMed
Google Scholar
Suski JM, Lebiedzinska M, Bonora M, Pinton P, Duszynski J, Wieckowski MR. Relation between mitochondrial membrane potential and ROS formation. Methods Mol Biol. 2012;810:183–205.
Article
CAS
PubMed
Google Scholar
Murphy MP. Mitochondrial dysfunction indirectly elevates ROS production by the endoplasmic reticulum. Cell Metab. 2013;18:145–6.
Article
CAS
PubMed
Google Scholar
Panieri E, Gogvadze V, Norberg E, Venkatesh R, Orrenius S, Zhivotovsky B. Reactive oxygen species generated in different compartments induce cell death, survival, or senescence. Free Radic Biol Med. 2013;57:176–87.
Article
CAS
PubMed
Google Scholar
Poillet-Perez L, Despouy G, Delage-Mourroux R, Boyer-Guittaut M. Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy. Redox Biol. 2015;4:184–92.
Article
CAS
PubMed
Google Scholar
Zafarullah M, Li WQ, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci. 2003;60:6–20.
Article
CAS
PubMed
Google Scholar
Sun S.-Y. N-acetylcysteine, reactive oxygen species and beyond. Cancer Biol Ther. 2010;9(2):109–10.
Article
PubMed
PubMed Central
Google Scholar
IARC. World Cancer Report 2014. 2014.
Google Scholar
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108.
Article
PubMed
Google Scholar
Klemm F, Joyce JA. Microenvironmental regulation of therapeutic response in cancer. Trends Cell Biol. 2015;25:198–213.
Article
PubMed
Google Scholar
Formenti SC, Demaria S. Combining radiotherapy and cancer immunotherapy: a paradigm shift. J Natl Cancer Inst Oxford University Press. 2013;105:256–65.
Article
CAS
Google Scholar
James ND, Hussain SA, Hall E, Jenkins P, Tremlett J, Rawlings C, et al. Radiotherapy with or without chemotherapy in muscle-invasive bladder cancer. N Engl J Med. 2012;366:1477–88.
Article
CAS
PubMed
Google Scholar
Fudenberg HH. DIALYZABLE TRANSFER FACTOR IN THE TREATMENT OF HUMAN OSTEOSARCOMA: AN ANALYTIC REVIEW. Ann. N. Y. Acad. Sci. Blackwell Publishing Ltd. 1976;277:545–57.
CAS
Google Scholar
Pizza G, De Vinci C, Cuzzocrea D, Menniti D, Aiello E, Maver P, et al. A preliminary report on the use of transfer factor for treating stage D3 hormone-unresponsive metastatic prostate cancer. Biotherapy Kluwer Academic Publishers. 1996;9:123–32.
CAS
Google Scholar
Pilotti V, Mastrorilli M, Pizza G, De Vinci C, Busutti L, Palareti A, et al. Transfer factor as an adjuvant to non-small cell lung cancer (NSCLC) therapy. Biotherapy Kluwer Academic Publishers. 1996;9:117–21.
CAS
Google Scholar
Franco-Molina MA, Mendoza-Gamboa E, Zapata-Benavides P, Vera-Garcia M. E. Castillo-Tello P, de la Fuente AG, Rodríguez-Padilla C. IMMUNEPOTENT CRP (bovine dialyzable leukocyte extract) adjuvant immunotherapy: a phase I study in non-small cell lung cancer patients. Cytotherapy. 2008;10:490–6.
Article
CAS
PubMed
Google Scholar
Krishnaveni M. A review on transfer factor an immune modulator. Drug Invent Today. 2013;5:153–6.
Article
CAS
Google Scholar
Hamprecht KH, Vötsch W, Anderer FA. A Dialysable acid factor from human leukocyte extracts activates tumor cell Lysis mediated by human Monocytes and natural killer cells. Oncol Res Treat Karger Publishers. 2009;12:120–7.
Article
Google Scholar
Spitler LE, Levin AS, Wybran J. Combined immunotherapy in malignant melanoma. Cell Immunol Academic Press. 1976;21:1–19.
Article
CAS
Google Scholar
Láng I, Nékám K, Gergely P, Petrányi G. Effect of in vivo and in vitro treatment with dialyzable leukocyte extracts on human natural killer cell activity. Clin Immunol Immunopathol Academic Press. 1982;25:139–44.
Article
Google Scholar
Nikoletopoulou V, Markaki M, Palikaras K, Tavernarakis N. Crosstalk between apoptosis, necrosis and autophagy. Biochim Biophys Acta - Mol Cell Res. 1833;2013:3448–59.
Google Scholar
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ Macmillan Publishers Limited. 2014;22:58–73.
Article
Google Scholar
Sun H, Yang S, Li J, Zhang Y, Gao D, Zhao S. Caspase-independent cell death mediated by apoptosis-inducing factor (AIF) nuclear translocation is involved in ionizing radiation induced HepG2 cell death. Biochem Biophys Res Commun. 2016;472(1):137–43.
Article
CAS
PubMed
Google Scholar
Wang L, Liu L, Shi Y, Cao H, Chaturvedi R, Calcutt MW, et al. Berberine induces Caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS One. 2012;7:e36418. Linden R, editor. Public Library of Science
Article
CAS
PubMed
PubMed Central
Google Scholar
Dubois A, Ginet C, Furstoss N, Belaid A, Hamouda MA, El Manaa W, et al. Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death. Oncotarget. 2016;7(18):26120–36.
Article
PubMed
PubMed Central
Google Scholar
Suparji NS, Chan G, Sapili H, Arshad NM, In LLA, Awang K, et al. Geranylated 4-Phenylcoumarins exhibit anticancer effects against human prostate cancer cells through Caspase-independent mechanism. PLoS One. 2016;11:e0151472. Ulasov I, editor. Public Library of Science
Article
PubMed
PubMed Central
Google Scholar
McLaughlin B. The kinder side of killer proteases: Caspase activation contributes to neuroprotection and CNS remodeling. Apoptosis Kluwer Academic Publishers. 2004;9:111–21.
CAS
Google Scholar
Abraham MC, Shaham S. Death without caspases, caspases without death. Trends Cell Biol. 2004;14:184–93.
Article
CAS
PubMed
Google Scholar
Gajek A, Denel M, Bukowska B, Rogalska A, Marczak A. Pro-apoptotic activity of new analog of anthracyclines – WP 631 in advanced ovarian cancer cell line. Toxicol Vitr. 2014;28:273–81.
Article
CAS
Google Scholar
Zec M, Srdic-Rajic T, Krivokuca A, Jankovic R, Todorovic T, Andelkovic K, et al. Novel Selenosemicarbazone metal complexes exert anti-tumor effect via alternative, Caspase-independent necroptotic cell death. Med Chem. 2014;10(8):759–71.
Article
CAS
PubMed
Google Scholar
Shirato K, Imaizumi K, Abe A, Tomoda A. Phenoxazine derivatives 2-Amino-4,4α-dihydro-4α-phenoxazine-3-one and 2-Aminophenoxazine-3-one-induced apoptosis through a Caspase-independent mechanism in human Neuroblastoma cell line NB-1 cells. Biol Pharm Bull. 2007;30:331–6.
Article
CAS
PubMed
Google Scholar
Zhou H, Xu M, Gao Y, Deng Z, Cao H, Zhang W, et al. Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor. Mol Cancer. 2014;13:59.
Article
PubMed
PubMed Central
Google Scholar
Cabon L, Galán-Malo P, Bouharrour A, Delavallée L, Brunelle-Navas M-N, Lorenzo HK, et al. BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation. Cell Death Differ. 2012;19:245–56.
Article
CAS
PubMed
Google Scholar
Dric Artus C, Boujrad H, Bouharrour A, Lle Brunelle M-N, Hoos S, Yuste VJ, et al. AIF promotes chromatinolysis and caspase- independent programmed necrosis by interacting with histone H2AX. EMBO J. 2010;2943:1585–99.
Article
Google Scholar
Yano H, Mizoguchi A, Fukuda K, Haramaki M, Ogasawara S, Momosaki S, et al. The herbal medicine sho-saiko-to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase. Cancer Res American Association for Cancer Research. 1994;54:448–54.
CAS
Google Scholar
Mantena SK, Sharma SD, Katiyar SK. Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells. Mol Cancer Ther Molecular Cancer Therapeutics. 2006;5:296–308.
Article
CAS
PubMed
Google Scholar
Bröker LE, Kruyt FAE, Giaccone G. Cell death independent of caspases: a review. Clin Cancer Res. 2005;11:3155–62.
Article
PubMed
Google Scholar
Ahmad N, Adhami VM, Afaq F, Feyes DK, Mukhtar H. Resveratrol causes WAF-1/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells. Clin Cancer Res. 2001;7:1466–73.
CAS
PubMed
Google Scholar
van Rijt SH, Romero-Canelón I, Fu Y, Shnyder SD, Sadler PJ. Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells. Metallomics. 2014;6:1014.
Article
CAS
PubMed
Google Scholar
Pal HC, Sharma S, Elmets CA, Athar M, Afaq F. Fisetin inhibits growth, induces G 2 /M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activation. Exp Dermatol. 2013;22:470–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bishayee K, Ghosh S, Mukherjee A, Sadhukhan R, Mondal J, Khuda-Bukhsh AR. Quercetin induces cytochrome-c release and ROS accumulation to promote apoptosis and arrest the cell cycle in G2/M, in cervical carcinoma: signal cascade and drug-DNA interaction. Cell Prolif. 2013;46:153–63.
Article
CAS
PubMed
Google Scholar
Hartwell LH, Kastan MB. Cell cycle control and cancer. Science (80- ). 1994;266:1821.
Article
CAS
Google Scholar
Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B, et al. Cell-cycle arrest versus cell death in cancer therapy. Nat Med. 1997;3:1034–6.
Article
CAS
PubMed
Google Scholar
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature Nature Publishing Group. 2004;432:316–23.
CAS
Google Scholar
Zhang Z, Wang C-Z, Du G-J, Qi L-W, Calway T, He T-C, et al. Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells. Int J Oncol Spandidos Publications. 2013;43:289–96.
Article
CAS
Google Scholar
Wu C-C, Huang K-F, Yang T-Y, Li Y-L, Wen C-L, Hsu S-L, et al. The Topoisomerase 1 inhibitor Austrobailignan-1 isolated from Koelreuteria Henryi induces a G2/M-phase arrest and cell death independently of p53 in non-small cell lung cancer cells. PLoS One. 2015;10:e0132052. Fei P, editor. Public Library of Science
Article
PubMed
PubMed Central
Google Scholar
Zhang X, Chen M, Zou P, Kanchana K, Weng Q, Chen W, et al. Curcumin analog WZ35 induced cell death via ROS-dependent ER stress and G2/M cell cycle arrest in human prostate cancer cells. BMC Cancer. 2015;15:866.
Article
PubMed
PubMed Central
Google Scholar
Nakajima H, Golstein P, Henkart PA. The target cell nucleus is not required for cell-mediated granzyme- or Fas-based cytotoxicity. J Exp Med. 1995;181:1905–9.
Article
CAS
PubMed
Google Scholar
Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O, Valko M, et al. Oxidative stress and antioxidant defense. World Allergy Organ J BioMed Central. 2012;5:9–19.
Article
CAS
Google Scholar
Dixon SJ, Stockwell BR. The role of iron and reactive oxygen species in cell death. Nat Chem Biol Nature Research. 2013;10:9–17.
Article
Google Scholar
Jacobson MD. Reactive oxygen species and programmed cell death. Trends Biochem Sci Elsevier Current Trends. 1996;21:83–6.
Article
CAS
Google Scholar
Rodríguez-Serrano M, Bárány I, Prem D, Coronado M-J, Risueño MC, Testillano PS. NO, ROS, and cell death associated with caspase-like activity increase in stress-induced microspore embryogenesis of barley. J Exp Bot Oxford University Press. 2012;63:2007–24.
Article
Google Scholar
Nathan C, Cunningham-Bussel A. Beyond oxidative stress: an immunologist’s guide to reactive oxygen species. Nat Rev Immunol Nature Publishing Group. 2013;13:349–61.
Article
CAS
Google Scholar
Tait SWG, Green DR. Cut. 2009;27:6452–61.
Google Scholar
Kang Y-H, Yi M-J, Kim M-J, Park M-T, Bae S, Kang C-M, et al. Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen species-mediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. Cancer Res. 2004;64:8960–7.
Article
CAS
PubMed
Google Scholar
Perdomo J, Cabrera J, Estévez F, Loro J, Reiter RJ, Quintana J. Melatonin induces apoptosis through a caspase-dependent but reactive oxygen species-independent mechanism in human leukemia Molt-3 cells. J Pineal Res. 2013;55:195–206.
Article
CAS
PubMed
Google Scholar
Evans MK, Tovmasyan A, Batinic-Haberle I, Devi GR. Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death. Free Radic Biol Med. 2014;68:302–14.
Article
CAS
PubMed
Google Scholar
Honeychurch J, Alduaij W, Azizyan M, Cheadle EJ, Pelicano H, Ivanov A, et al. Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway. Blood. 2012;119(15):3523–33.
Article
CAS
PubMed
Google Scholar
Franco-Molina M, Mendoza-Gamboa E, Castillo-Tello P, Isaza-Brando C, García MV, Castillo-León L, et al. Bovine dialyzable leukocyte extract modulates cytokines and nitric oxide production in lipopolysaccharide-stimulated human blood cells. Cytotherapy. 2007;9(4):379–85.
Article
CAS
PubMed
Google Scholar
Franco-Molina MA, Mendoza-Gamboa E, Castillo-León L, Tamez-Guerra RS, Rodríguez-Padilla C. Bovine dialyzable leukocyte extract modulates the nitric oxide and pro-inflammatory cytokine production in Lipopolysaccharide-stimulated Murine peritoneal macrophages in vitro. 2 Madison Avenue Larchmont, NY 10538 USA: Mary Ann Liebert, Inc; 2005.
Google Scholar
Festjens N, Vanden Berghe T, Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta. 2006;1757:1371–87.
Article
CAS
PubMed
Google Scholar
Yuzefovych LV, LeDoux SP, Wilson GL, Rachek LI. Mitochondrial DNA damage via augmented oxidative stress regulates endoplasmic reticulum stress and autophagy: crosstalk, links and signaling. PLoS One. 2013;8:e83349.
Article
PubMed
PubMed Central
Google Scholar