Gökbuget N, Hoelzer D. Treatment of adult acute lymphoblastic leukemia. Semin Hematol. 2009;46:64–75.
Article
PubMed
Google Scholar
Hunault M, Harousseau J-L, Delain M, Truchan-Graczyk M, Cahn J-Y, Witz F, et al. Better outcome of adult acute lymphoblastic leukemia after early genoidentical allogeneic bone marrow transplantation (BMT) than after late high-dose therapy and autologous BMT: a GOELAMS trial. Blood. 2004;104:3028–37.
Article
CAS
PubMed
Google Scholar
Annunziata M, Granata R, Ghigo E. The IGF system. Acta Diabetol. 2011;48:1–9.
Article
CAS
PubMed
Google Scholar
Hwa V, Oh Y, Rosenfeld R. The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocr Rev. 1999;20:761–87.
CAS
PubMed
Google Scholar
Baxter RC. Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities. Am J Physiol - Endocrinol Metab. 2000;278:E967–76.
CAS
PubMed
Google Scholar
Ingermann AR, Yang Y, Han J, Mikami A, Garza AE, Mohanraj L, et al. Identification of a Novel Cell Death Receptor Mediating IGFBP-3-induced Antitumor Effects in Breast and Prostate Cancer. J Biol Chem. 2010;285:30233–46.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schedlich LJ, Le Page SL, Firth SM, Briggs LJ, Jans DA, Baxter RC. Nuclear import of insulin-like growth factor-binding protein-3 and −5 is mediated by the importin beta subunit. J Biol Chem. 2000;275:23462–70.
Article
CAS
PubMed
Google Scholar
Azar WJ, Zivkovic S, Werther GA, Russo VC. IGFBP-2 nuclear translocation is mediated by a functional NLS sequence and is essential for its pro-tumorigenic actions in cancer cells. Oncogene. 2014;33:578–88.
Article
CAS
PubMed
Google Scholar
Landberg G, Ostlund H, Nielsen NH, Roos G, Emdin S, Burger AM, et al. Downregulation of the potential suppressor gene IGFBP-rP1 in human breast cancer is associated with inactivation of the retinoblastoma protein, cyclin E overexpression and increased proliferation in estrogen receptor negative tumors. Oncogene. 2001;20:3497–505.
Article
CAS
PubMed
Google Scholar
Ruan W, Xu E, Xu F, Ma Y, Deng H, Huang Q, et al. IGFBP7 Plays a Potential Tumor Suppressor Role in Colorectal Carciogenesis. Cancer Biol Ther. 2007;6:354–9.
Article
CAS
PubMed
Google Scholar
Tomimaru Y, Enguchi H, Wada H, Kobayashi S, Marubashi S, Tanemura M, et al. IGFBP7 downregulation is associated with tumor supression and clinical outcome in heptocellular carcinoma. Int J Cancer. 2012;130:319–27.
Article
CAS
PubMed
Google Scholar
Chen D, Siddiq A, Emdad L, Rajasekaran D, Gredler R, Shen X-N, et al. Insulin-like growth factor-binding protein-7 (IGFBP7): a promising gene therapeutic for hepatocellular carcinoma (HCC). Mol Ther. 2013;21:758–66.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen R-Y, Chen H-X, Lin J-X, She W-B, Jiang P, Xu L, et al. In-vivo transfection of pcDNA3.1-IGFBP7 inhibits melanoma growth in mice through apoptosis induction and VEGF downexpression. J Exp Clin Cancer Res. 2010;29:13.
Article
PubMed
PubMed Central
Google Scholar
Chen R-Y, Chen H-X, Jian P, Xu L, Li J, Fan Y-M, et al. Intratumoral injection of pEGFC1-IGFBP7 inhibits malignant melanoma growth in C57BL/6 J mice by inducing apoptosis and down-regulating VEGF expression. Oncol Rep. 2010;23:981–8.
CAS
PubMed
Google Scholar
Heesch S, Schlee C, Neumann M, Stroux A, Kühnl A, Schwartz S, et al. BAALC-associated gene expression profiles define IGFBP7 as a novel molecular marker in acute leukemia. Leukemia. 2010;24:1429–36.
Article
CAS
PubMed
Google Scholar
Benatar T, Yang W, Amemiya Y, Evdokimova V, Kahn H, Holloway C, et al. IGFBP7 reduces breast tumor growth by induction of senescence and apoptosis pathways. Breast Cancer Res Treat. 2012;133:563–73.
Article
CAS
PubMed
Google Scholar
Vizioli MG, Sensi M, Miranda C, Cleris L, Formelli F, Anania MC, et al. IGFBP7: an oncosuppressor gene in thyroid carcinogenesis. Oncogene. 2010;29:3835–44.
Article
CAS
PubMed
Google Scholar
Zuo S, Liu C, Wang J, Wang F, Xu W, Cui S, et al. IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells. J Cancer Res Clin Oncol. 2012;138:1045–55.
Article
CAS
PubMed
Google Scholar
Ma Y, Lu B, Ruan W, Wang H, Lin J, Hu H, et al. Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cells. Exp Mol Pathol. 2008;85:141–5.
Article
CAS
PubMed
Google Scholar
Hu S, Chen R, Man X, Feng X, Cen J, Gu W, et al. Function and expression of insulin-like growth factor-binding protein 7 (IGFBP7) gene in childhood acute myeloid leukemia. Pediatr Hematol Oncol. 2011;28:279–87.
Article
CAS
PubMed
Google Scholar
Laranjeira AB, De Vasconcellos JF, Sodek L, Spago MC, Fornazim MC, Tone LG, et al. IGFBP7 Participates in the Reciprocal Interaction between Acute Lymphoblastic Leukemia and BM Stromal Cells and in Leukemia Resistance to Asparaginase. Leukemia. 2012;26:1001–11.
Article
CAS
PubMed
Google Scholar
Bohne A, Schlee C, Mossner M, Thibaut J, Heesch S, Thiel E, et al. Epigenetic control of differential expression of specific ERG isoforms in acute T-lymphoblastic leukemia. Leuk Res. 2009;33:817–22.
Article
CAS
PubMed
Google Scholar
Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3:1101–8.
Article
CAS
PubMed
Google Scholar
Haferlach T, Kohlmann A, Wieczorek L, Basso G, Te KG, Béné M-C, et al. Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group. J Clin Oncol. 2010;28:2529–37.
Article
CAS
PubMed
Google Scholar
Anderson MA, Huang D, Roberts A. Targeting BCL2 for the Treatment of Lymphoid Malignancies. Semin Hematol. 2014;51:219–27.
Article
CAS
PubMed
Google Scholar
Choi CH, Sung CO, Kim HJ, Lee YY, Song SY, Song T, et al. Overexpression of annexin A4 is associated with chemoresistance in papillary serous adenocarcinoma of the ovary. Hum Pathol. 2013;44:1017–23.
Article
CAS
PubMed
Google Scholar
Roszak J, Smok-Pienia̧zek A, Nocuń M, Stȩpnik M. Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: Focus on PI3K/Akt signaling pathway. Chem Biol Interact. 2013;205:198–211.
Article
CAS
PubMed
Google Scholar
Trbusek M, Malcikova J. TP53 aberrations in chronic lymphocytic leukemia. Adv Exp Med Biol. 2013;792:109–31.
Article
CAS
PubMed
Google Scholar
Raval A, Tanner SM, Byrd JC, Angerman EB, Perko JD, Chen SS, et al. Downregulation of Death-Associated Protein Kinase 1 (DAPK1) in Chronic Lymphocytic Leukemia. Cell. 2007;129:879–90.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ferrando AA. The role of NOTCH1 signaling in T-ALL. Hematology Am Soc Hematol Educ Program. 2009;1:253-361
Lee DW, Zhang K, Ning ZQ, Raabe EH, Tintner S, Wieland R, et al. Proliferation-associated SNF2-like gene (PASG): A SNF2 family member altered in leukemia. Cancer Res. 2000;60:3612–22.
CAS
PubMed
Google Scholar
Shah MA, Schwartz GK. Cell Cycle-mediated Drug Resistance : An Emerging Concept in Cancer Therapy Cell Cycle-mediated Drug Resistance : An Emerging Concept in. Clin Cancer Res. 2001;7:2168–81.
CAS
PubMed
Google Scholar
Evdokimova V, Tognon CE, Benatar T, Yang W, Krutikov K, Pollak M, et al. IGFBP7 binds to the IGF-1 receptor and blocks its activation by insulin-like growth factors. Sci Signal. 2012;5:ra92.
Article
PubMed
Google Scholar
Verhagen HJ, De Leeuw DC, Roemer MG, Denkers F, Pouwels W, Rutten A, et al. IGFBP7 induces apoptosis of acute myeloid leukemia cells and synergizes with chemotherapy in suppression of leukemia cell survival. Cell Death Dis. 2014;5:e1300.
Article
CAS
PubMed
PubMed Central
Google Scholar
He Y, Zhang J, Zheng J, Du W, Xiao H, Liu W, et al. The Insulin-Like Growth Factor-1 Receptor Kinase Inhibitor, NVP-ADW742, Suppresses Survival and Resistance to Chemotherapy in Acute Myeloid Leukemia Cells. Oncol Res Featur Preclin Clin Cancer Ther. 2010;19:35–43.
CAS
Google Scholar
Tazzari PL, Tabellini G, Bortul R, Papa V, Evangelisti C, Grafone T, et al. The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretion. Leukemia. 2007;21:886–96.
CAS
PubMed
Google Scholar
Doepfner KT, Spertini O, Arcaro A. Autocrine insulin-like growth factor-I signaling promotes growth and survival of human acute myeloid leukemia cells via the phosphoinositide 3-kinase/Akt pathway. Leukemia. 2007;21:1921–30.
Article
CAS
PubMed
Google Scholar
Gualberto A, Pollak M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene. 2009;28:3009–21.
Article
CAS
PubMed
Google Scholar
Medyouf H, Gusscott S, Wang H, Tseng J-C, Wai C, Nemirovsky O, et al. High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling. J Exp Med. 2011;208:1809–22.
Article
CAS
PubMed
PubMed Central
Google Scholar
Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306:269–71.
Article
CAS
PubMed
Google Scholar
Reed JC. Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance. Curr Opin Oncol. 1995;7:541–6.
Article
CAS
PubMed
Google Scholar
Singleton JR, Dixit VM, Feldman EL. Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins. J Biol Chem. 1996;271:31791–4.
Article
CAS
PubMed
Google Scholar
Basu S, Rajakaruna S, Menko AS. Insulin-like growth factor receptor-1 and nuclear factor κB are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation. J Biol Chem. 2012;287:8384–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yee D. Insulin-like Growth Factor Receptor Inhibitors: Baby or the Bathwater? J Natl Cancer Inst. 2012;104:975–81.
Article
CAS
PubMed
PubMed Central
Google Scholar