Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin. 2014;64:9–29.
Article
PubMed
Google Scholar
Mandel JS, Bond JH, Church TR, Snover DC, Bradley GM, Schuman LM, et al. Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N Engl J Med. 1993;328:1365–71.
Article
CAS
PubMed
Google Scholar
Kronborg O, Fenger C, Olsen J, Jørgensen OD, Søndergaard O. Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet. 1996;348:1467–71.
Article
CAS
PubMed
Google Scholar
Hardcastle JD, Chamberlain JO, Robinson MH, Moss SM, Amar SS, Balfour TW, et al. Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet. 1996;348:1472–7.
Article
CAS
PubMed
Google Scholar
Mandel JS, Church TR, Church BJH, Bond EF, et al. The Effect of Fecal Occult-Blood Screening on the Incidence of Colorectal Cancer. N Engl J Med. 2000;343:1603–7.
Article
CAS
PubMed
Google Scholar
Holme Ø, Løberg M, Kalager M, Bretthauer M, Hernán MA, Aas E, et al. Effect of Flexible Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality: A Randomized Clinical Trial. JAMA. 2014;312:606–15.
Article
CAS
PubMed
PubMed Central
Google Scholar
Australian Institute of Health, Welfare. National Bowel Cancer Screening Program monitoring report 2012-2013. Cancer Series. 2014;81:1–142.
Google Scholar
Adler A, Geiger S, Keil A, Bias H, Schatz P, deVos T, et al. Improving compliance to colorectal cancer screening using blood and stool based tests in patients refusing screening colonoscopy in Germany. BMC Gastroenterol. 2014;14:1–8.
Article
Google Scholar
Osborne JM, Wilson C, Moore V, Gregory T, Flight I, Young GP. Sample preference for colorectal cancer screening tests: Blood or stool? OJPM. 2012;2:326–31.
Article
Google Scholar
Kibriya MG, Raza M, Jasmine F, Roy S, Paul-Brutus R, Rahaman R, et al. A genome-wide DNA methylation study in colorectal carcinoma. BMC Med Genomics. 2011;4:50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Øster B, Thorsen K, Lamy P, Wojdacz TK, Hansen LL, Birkenkamp-Demtröder K, et al. Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas. Int J Cancer. 2011;129:2855–66.
Article
PubMed
Google Scholar
deVos T, Tetzner R, Model F, Weiss G, Schuster M, Distler J, et al. Circulating Methylated SEPT9 DNA in Plasma Is a Biomarker for Colorectal Cancer. Clin Chem. 2009;55:1337–46.
Article
CAS
PubMed
Google Scholar
Church TR, Wandell M, Lofton-Day C, Mongin SJ, Burger M, Payne SR, et al. Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer. Gut. 2014;63:317–25.
Article
CAS
PubMed
Google Scholar
Mitchell SM, Ross JP, Drew HR, Ho T, Brown GS, Saunders NF, et al. A panel of genes methylated with high frequency in colorectal cancer. BMC Cancer. 2014;14:54.
Article
PubMed
PubMed Central
Google Scholar
Pedersen SK, Baker RT, McEvoy A, Murray DH, Thomas M, Molloy PL, et al. A two-gene blood test for methylated DNA sensitive for colorectal cancer. PLoS One. 2015;10:e0125041.
Article
PubMed
PubMed Central
Google Scholar
Allison JE, Fraser CG, Halloran SP, Young GP. Population screening for colorectal Cancer means getting FIT: The Past, Present, and Future of colorectal cancer screening using the Fecal Immunochemical Test for Hemoglobin (FIT). Gut and Liver. 2014;8:117–30.
Article
PubMed
PubMed Central
Google Scholar
Lord SJ, Irwig L, Simes RJ. When Is Measuring Sensitivity and Specificity Sufficient To Evaluate a Diagnostic Test, and When Do We Need Randomized Trials? Ann Intern Med. 2006;144:850–5.
Article
PubMed
Google Scholar
Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann of Surg Oncol. 2010;17:1471–4.
Article
Google Scholar
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136:E359–86.
Article
CAS
PubMed
Google Scholar
Whitlock EP, Lin JS, Liles E, Beil TL, Fu R. Screening for colorectal cancer: a targeted, updated systematic review for the U.S. Preventive Services Task Force. Ann Intern Med. 2008;149:638–58.
Article
PubMed
Google Scholar
Lansdorp-Vogelaar I, van Ballegooijen M, Boer R, Zauber A, Habbema JDF. A novel hypothesis on the sensitivity of the fecal occult blood test: Results of a joint analysis of 3 randomized controlled trials. Cancer. 2009;115:2410–9.
Article
PubMed
PubMed Central
Google Scholar
Imperiale TF, Ransohoff DF, Itzkowitz SH, Levin TR, Lavin P, Lidgard GP, et al. Multitarget Stool DNA Testing for Colorectal-Cancer Screening. N Engl J Med. 2014;370:1287–97.
Article
CAS
PubMed
Google Scholar
Lane JM, Chow E, Young GP, Good N, Smith A, Bull J, et al. Interval fecal immunochemical testing in a colonoscopic surveillance program speeds detection of colorectal neoplasia. Gastroenterology. 2010;139:1918–26.
Article
PubMed
Google Scholar
Lofton-Day C, Model F, deVos T, Tetzner R, Distler J, Schuster M, et al. DNA methylation biomarkers for blood-based colorectal cancer screening. Clin Chem. 2008;54:414–23.
Article
CAS
PubMed
Google Scholar
Grützmann R, Molnar B, Pilarsky C, Habermann JK, Schlag PM, Saeger HD, et al. Sensitive Detection of Colorectal Cancer in Peripheral Blood by Septin 9 DNA Methylation Assay. PLoS One. 2008;3:e3759–68.
Article
PubMed
PubMed Central
Google Scholar
Warren JD, Xiong W, Bunker AM, Vaughn CP, Furtado LV, Roberts WL, et al. Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Med. 2011;9:133.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yong E. Cancer biomarkers: Written in blood. Nature. 2014;511:524–6.
Article
CAS
PubMed
Google Scholar
Newman AM, Bratman SV, To J, Wynne JF, Eclov NCW, Modlin LA, et al. An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage. Nat Med. 2014;20:548–54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Young GP, Symonds EL, Allison JE, Cole SR, Fraser CG, Halloran SP, et al. Advances in Fecal Occult Blood Tests: The FIT Revolution. Dig Dis Sci. 2015;60:609–22.
Article
PubMed
Google Scholar
Zhang Z, Xu Z, Wang X, Wang H, Yao Z, Mu Y, et al. Ectopic Ikaros expression positively correlates with lung cancer progression. Anat Rec (Hoboken). 2013;296:907–13.
Article
CAS
Google Scholar
Tonjes M, Barbus S, Park YJ, Wang W, Schlotter M, Lindroth AM, et al. BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Nat Med. 2013;19:901–8.
Article
PubMed
PubMed Central
Google Scholar
Vincent A, Omura N, Hong SM, Jaffe A, Eshleman J, Goggins M. Genome-Wide Analysis of Promoter Methylation Associated with Gene Expression Profile in Pancreatic Adenocarcinoma. Clin Cancer Res. 2011;17:4341–54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yoshikawa R, Yanagi H, Shen C-S, Fujiwara Y, Noda M, Yagyu T, et al. ECA39 is a novel distant metastasis-related biomarker in colorectal cancer. World J Gastroenterol. 2006;12:5884–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Javierre BM, Rodriguez-Ubreva J, Al-Shahrour F, Corominas M, Grana O, Ciudad L, et al. Long-Range Epigenetic Silencing Associates with Deregulation of Ikaros Targets in Colorectal Cancer Cells. Mol Cancer Res. 2011;9:1139–51.
Article
CAS
PubMed
Google Scholar
Iacobucci I, Storlazzi CT, Cilloni D, Lonetti A, Ottaviani E, Soverini S, et al. Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP). Blood. 2009;114:2159–67.
Article
CAS
PubMed
Google Scholar
Malinge S, Thiollier C, Chlon TM, Dore LC, Diebold L, Bluteau O, et al. Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling. Blood. 2013;121:2440–51.
Article
CAS
PubMed
PubMed Central
Google Scholar
Riccio O, van Gijn ME, Bezdek AC, Pellegrinet L, van Es JH, Zimber-Strobl U, et al. Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. EMBO. 2008;9:377–83.
Article
CAS
Google Scholar
Noah TK, Shroyer NF. Notch in the Intestine: Regulation of Homeostasis and Pathogenesis. Annu Rev of Physiol. 2013;75:263–88.
Article
CAS
Google Scholar
Diehl F, Schmidt K, Choti MA, Romans K, Goodman S, Li M, et al. Circulating mutant DNA to assess tumor dynamics. Nat Med. 2008;14:985–90.
Article
CAS
PubMed
Google Scholar
Tham C, Chew M, Soong R, Lim J, Ang M, Tang C, et al. Postoperative serum methylation levels of TAC1 and SEPT9 are independent predictors of recurrence and survival of patients with colorectal cancer. Cancer. 2014;120:3131–41.
Article
CAS
PubMed
Google Scholar