|
Most advanced findings
|
No. (%)
|
Positivity Counts (%); 95 % CI
| |
|---|
|
BCAT1
|
IKZF1
|
Either marker
|
OR (95 % CI)1
|
X
2
|
|---|
|
ALL CASES
|
2101
|
181 (9); 8-10
|
89 (4); 3-5
|
204 (10); 8-11
| | |
|
Cancer
|
129 (6)
|
74 (57); 48 - 66
|
62 (48); 39 - 57
|
85 (66); 57 - 74
|
34 (20 - 59)**
|
241**
|
|
Stage I
|
29 (22)
|
7 (24); 10 - 44
|
8 (28); 13 - 47
|
11 (38); 21 - 58
|
11 (5 - 26)**
|
43**
|
|
Stage II
|
42 (33)
|
26 (62); 46 - 76
|
17 (40); 26 - 57
|
29 (69); 53 - 82
|
40 (18 - 86)**
|
16**
|
|
Stage III
|
40 (31)
|
27 (68); 51 - 81
|
22 (55); 38 - 71
|
29 (73); 56 - 85
|
47 (21 - 105)**
|
172**
|
|
Stage IV
|
16 (12)
|
13 (81); 54 - 96
|
15 (94);70 - 100
|
15 (94);70 - 100
|
266 (34-2101)**
|
158**
|
|
Unstaged
|
2 (2)
|
1 (50); 1 - 99
|
0 (0); 0 - 80
|
1 (50); 1 - 99
|
18 (1 - 293)**
|
8*
|
|
Early Stage (I + II)
|
71 (55)
|
33 (46); 35 - 59
|
25 (35); 24 - 47
|
40 (56); 44 - 68
|
23 (12 - 43)**
|
148**
|
|
Late Stage (III + IV)
|
56 (43)
|
40 (71); 58 - 83
|
37 (66); 52 - 78
|
44 (79); 66 - 88
|
65 (30 - 139)**
|
230**
|
|
Adv. adenoma2
|
338(16)
|
16 (5); 3 - 8
|
7 (2); 1 - 4
|
20 (6); 4 - 9
|
1.1 (0.6 - 2)
|
0.1
|
|
HGD
|
32 (9)
|
2 (6); 1 - 21
|
1 (3); 0.1 - 16
|
2 (6); 0.1 - 21
|
1.2 (0.3 - 5)
|
0.1
|
|
TVA3
|
144(43)
|
7 (5); 2 - 10
|
0 (0); 0 - 20
|
7 (5); 2 - 10
|
0.9 (0.4 - 2)
|
0.1
|
|
≥10mm4
|
107(32)
|
3 (3); 1 - 8
|
4 (4); 1 - 9
|
5 (5); 2 - 11
|
0.9 (0.3 - 2)
|
0.1
|
|
≥3 TAs (<10mm)
|
34 (10)
|
4 (12); 3 - 27
|
0 (0); 0 - 10
|
4 (12); 3 - 27
|
2.4 (1 - 7)
|
2.4
|
|
Serrated Adenoma
|
19 (6)
|
0 (0); 0 - 20
|
2 (11); 2 - 52
|
2 (11); 2 - 52
|
2 (0.5 - 10)
|
0.9
|
|
Non adv. adenoma
|
346(16)
|
23 (7); 4 - 10
|
2 (1); 0.1 - 2
|
23 (7); 4 - 10
|
1.3 (0.7 - 2)
|
0.6
|
|
No neoplasia
|
838(40)
|
46 (6); 4 - 7
|
15 (2); 1 - 3
|
52 (6); 5 - 8
|
1.2 (0.7 - 2)
|
0.4
|
|
IBD5
|
61 (3)
|
3 (5); 1 - 14
|
0 (0); 0 - 6
|
3 (5); 1 - 14
|
0.9 (0.3- 3)
|
0.01
|
|
Non neoplastic polyps6
|
296(14)
|
16 (5); 3 - 9
|
4 (2); 0.4 - 4
|
18 (6); 4 - 9
|
1.1 (0.6 - 2)
|
0.2
|
|
Hemorrhoids
|
288(60)
|
14 (5); 3 - 8
|
6 (2); 1 - 4
|
16 (6); 3 - 9
|
1.0 (0.5 - 2)
|
0.02
|
|
Angiodysplasia
|
11 (0.5)
|
2 (18); 2 - 52
|
0 (0); 0 – 28
|
2 (18); 2 - 52
|
4 (1 -19)
|
3
|
|
Diverticular disease
|
182(38)
|
11 (6); 3 - 11
|
5 (3); 1 - 6
|
13 (7); 4 - 12
|
1.3 (0.7 - 3)
|
0.8
|
|
Normal colon/rectum
|
450(21)
|
22 (5); 3 - 7
|
3 (1); 0 - 2
|
24 (5); 3 - 8
|
1
|
1
|
- 1Calculation of Odds Ratios (OR) or Chi-square (X2) values against normal colon/rectum; *P-values <0.05, **P-values <0.001; 2Advanced adenoma including Stage 0 cancers; 3Excluding HGD; 4no HGD or TVA; 5Inflammatory bowel disease 6Hyperplastic, unspecified and other polyps
- HGD high-grade dysplasia, TVA tubulovillous adenoma, TA tubular adenoma, IBD inflammatory bowel disease
