Chinyama CN, Marshall RE, Owen WJ, Mason RC, Kothari D, Wilkinson ML, Sanderson JD: Expression of MUC1 and MUC2 mucin gene products in Barrett's metaplasia, dysplasia and adenocarcinoma: an immunopathological study with clinical correlation. Histopathology. 1999, 35 (6): 517-524. 10.1046/j.1365-2559.1999.00791.x.
Article
CAS
PubMed
Google Scholar
Pera M, Pera M, de Bolos C, Brito MJ, Palacin A, Grande L, Cardesa A, Poulsom R: Duodenal-content reflux into the esophagus leads to expression of Cdx2 and Muc2 in areas of squamous epithelium in rats. J Gastrointest Surg. 2007, 11 (7): 869-874. 10.1007/s11605-007-0162-7.
Article
PubMed
Google Scholar
Tytgat KM, Buller HA, Opdam FJ, Kim YS, Einerhand AW, Dekker J: Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin. Gastroenterology. 1994, 107 (5): 1352-1363.
Article
CAS
PubMed
Google Scholar
Allen A, Hutton DA, Pearson JP: The MUC2 gene product: a human intestinal mucin. Int J Biochem Cell Biol. 1998, 30 (7): 797-801. 10.1016/S1357-2725(98)00028-4.
Article
CAS
PubMed
Google Scholar
Warson C, Bovenkamp Van De JH, Korteland-Van Mal AM, Buller HA, Einerhand AW, Ectors NL, Dekker J: Barrett's esophagus is characterized by expression of gastric-type mucins (MUC5AC, MUC6) and TFF peptides (TFF1 and TFF2), but the risk of carcinoma development may be indicated by the intestinal-type mucin, MUC2. Hum Pathol. 2002, 33 (6): 660-668. 10.1053/hupa.2002.124907.
Article
CAS
PubMed
Google Scholar
Guillem P, Billeret V, Buisine MP, Flejou JF, Lecomte-Houcke M, Degand P, Aubert JP, Triboulet JP, Porchet N: Mucin gene expression and cell differentiation in human normal, premalignant and malignant esophagus. International journal of cancer. 2000, 88 (6): 856-861. 10.1002/1097-0215(20001215)88:6<856::AID-IJC3>3.0.CO;2-D.
Article
CAS
PubMed
Google Scholar
Yen C-J, Izzo JG, Lee D-F, Guha S, Wei Y, Wu T-T, Chen C-T, Kuo H-P, Hsu J-M, Sun H-L, et al: Bile Acid Exposure Up-regulates Tuberous Sclerosis Complex 1/Mammalian Target of Rapamycin Pathway in Barrett's-Associated Esophageal Adenocarcinoma. Cancer Res. 2008, 68 (8): 2632-2640. 10.1158/0008-5472.CAN-07-5460.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jenkins GJS, Cronin J, Alhamdani A, Rawat N, D'Souza F, Thomas T, Eltahir Z, Griffiths AP, Baxter JN: The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-{kappa}B activation in oesophageal cells, with a mechanism of action involving ROS. Mutagenesis. 2008, 23 (5): 399-405. 10.1093/mutage/gen029.
Article
CAS
PubMed
Google Scholar
Chen KH, Mukaisho K, Sugihara H, Araki Y, Yamamoto G, Hattori T: High animal-fat intake changes the bile-acid composition of bile juice and enhances the development of Barrett's esophagus and esophageal adenocarcinoma in a rat duodenal-contents reflux model. Cancer Sci. 2007, 98 (11): 1683-1688. 10.1111/j.1349-7006.2007.00605.x.
Article
CAS
PubMed
Google Scholar
Song S, Guha S, Liu K, Buttar NS, Bresalier RS: COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinoma. Gut. 2007, 56 (11): 1512-1521. 10.1136/gut.2007.121244.
Article
CAS
PubMed
PubMed Central
Google Scholar
Xia HH-X, Zhang ST, Lam SK, Lin MC-M, Kung HF, Wong BC-Y: Expression of macrophage migration inhibitory factor in esophageal squamous cell carcinoma and effects of bile acids and NSAIDs. Carcinogenesis. 2005, 26 (1): 11-15. 10.1093/carcin/bgh279.
Article
CAS
PubMed
Google Scholar
Kazumori H, Ishihara S, Rumi MAK, Kadowaki Y, Kinoshita Y: Bile acids directly augment caudal related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium. Gut. 2006, 55 (1): 16-25. 10.1136/gut.2005.066209.
Article
CAS
PubMed
PubMed Central
Google Scholar
Roman S, Petre A, Thepot A, Hautefeuille A, Scoazec J-Y, Mion F, Hainaut P: Downregulation of p63 upon exposure to bile salts and acid in normal and cancer esophageal cells in culture. American journal of physiology. 2007, 293 (1): G45-53. 10.1152/ajpcell.00450.2006.
Article
CAS
PubMed
Google Scholar
Mariette C, Perrais M, Leteurtre E, Jonckheere N, Hemon B, Pigny P, Batra S, Aubert JP, Triboulet JP, Van Seuningen I: Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway. The Biochemical journal. 2004, 377 (Pt 3): 701-708.
Article
CAS
PubMed
PubMed Central
Google Scholar
Piessen G, Jonckheere N, Vincent A, Hemon B, Ducourouble MP, Copin MC, Mariette C, Van Seuningen I: Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha. The Biochemical journal. 2007, 402 (1): 81-91. 10.1042/BJ20061461.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mariette C, Piessen G, Leteurtre E, Hemon B, Triboulet JP, Van Seuningen I: Activation of MUC1 mucin expression by bile acids in human esophageal adenocarcinomatous cells and tissues is mediated by the phosphatidylinositol 3-kinase. Surgery. 2008, 143 (1): 58-71. 10.1016/j.surg.2007.07.043.
Article
PubMed
Google Scholar
Gum JR, Hicks JW, Kim YS: Identification and characterization of the MUC2 (human intestinal mucin) gene 5'-flanking region: promoter activity in cultured cells. The Biochemical journal. 1997, 325 (Pt 1): 259-267.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gray T, Nettesheim P, Basbaum C, Koo J: Regulation of mucin gene expression in human tracheobronchial epithelial cells by thyroid hormone. The Biochemical journal. 2001, 353 (Pt 3): 727-734. 10.1042/0264-6021:3530727.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mesquita P, Jonckheere N, Almeida R, Ducourouble M-P, Serpa J, Silva E, Pigny P, Silva FS, Reis C, Silberg D, et al: Human MUC2 Mucin Gene Is Transcriptionally Regulated by Cdx Homeodomain Proteins in Gastrointestinal Carcinoma Cell Lines. J Biol Chem. 2003, 278 (51): 51549-51556. 10.1074/jbc.M309019200.
Article
CAS
PubMed
Google Scholar
Schwenzer R, Siemienski K, Liptay S, Schubert G, Peters N, Scheurich P, Schmid RM, Wajant H: The Human Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 Gene (TRAF1) Is Up-regulated by Cytokines of the TNF Ligand Family and Modulates TNF-induced Activation of NF-kappa B and c-Jun N-terminal Kinase. J Biol Chem. 1999, 274 (27): 19368-19374. 10.1074/jbc.274.27.19368.
Article
CAS
PubMed
Google Scholar
Wajant H, Haas E, Schwenzer R, Muhlenbeck F, Kreuz S, Schubert G, Grell M, Smith C, Scheurich P: Inhibition of Death Receptor-mediated Gene Induction by a Cycloheximide-sensitive Factor Occurs at the Level of or Upstream of Fas-associated Death Domain Protein (FADD). J Biol Chem. 2000, 275 (32): 24357-24366. 10.1074/jbc.M000811200.
Article
CAS
PubMed
Google Scholar
Mahmoud NN, Dannenberg AJ, Bilinski RT, Mestre JR, Chadburn A, Churchill M, Martucci C, Bertagnolli MM: Administration of an unconjugated bile acid increases duodenal tumors in a murine model of familial adenomatous polyposis. Carcinogenesis. 1999, 20 (2): 299-303. 10.1093/carcin/20.2.299.
Article
CAS
PubMed
Google Scholar
Wali RK, Khare S, Tretiakova M, Cohen G, Nguyen L, Hart J, Wang J, Wen M, Ramaswamy A, Joseph L, et al: Ursodeoxycholic Acid and F6-D3 Inhibit Aberrant Crypt Proliferation in the Rat Azoxymethane Model of Colon Cancer: Roles of Cyclin D1 and E-Cadherin. Cancer Epidemiol Biomarkers Prev. 2002, 11 (12): 1653-1662.
CAS
PubMed
Google Scholar
Jenkins GJS, Harries K, Doak SH, Wilmes A, Griffiths AP, Baxter JN, Parry JM: The bile acid deoxycholic acid (DCA) at neutral pH activates NF-{kappa}B and induces IL-8 expression in oesophageal cells in vitro. Carcinogenesis. 2004, 25 (3): 317-323. 10.1093/carcin/bgh032.
Article
CAS
PubMed
Google Scholar
Liu Jun-Feng, GGJPADG-JZS-WZT-NZB-ESQ-ZW: Aspirin induces apoptosis in oesophageal cancer cells by inhibiting the pathway of NF-kappaB downstream regulation of cyclooxygenase-2. ANZ journal of surgery. 2005, 75 (11): 1011-1016. 10.1111/j.1445-2197.2005.03596.x.
Article
PubMed
Google Scholar
Kaur BS, Triadafilopoulos G: Acid- and bile-induced PGE2 release and hyperproliferation in Barrett's esophagus are COX-2 and PKC-epsilon dependent. American journal of physiology. 2002, 283 (2): G327-334.
CAS
PubMed
Google Scholar
Lee H-W, Ahn D-H, Crawley SC, Li J-D, Gum JR, Basbaum CB, Fan NQ, Szymkowski DE, Han S-Y, Lee BH, et al: Phorbol 12-Myristate 13-Acetate Up-regulates the Transcription of MUC2 Intestinal Mucin via Ras, ERK, and NF-kappa B. J Biol Chem. 2002, 277 (36): 32624-32631. 10.1074/jbc.M200353200.
Article
CAS
PubMed
Google Scholar
Song S, Byrd JC, Koo JS, Bresalier RS: Bile acids induce MUC2 overexpression in human colon carcinoma cells. Cancer. 2005, 103 (8): 1606-1614. 10.1002/cncr.21015.
Article
CAS
PubMed
Google Scholar
Hu Y, Jones C, Gellersen O, Williams VA, Watson TJ, Peters JH: Pathogenesis of Barrett Esophagus: Deoxycholic Acid Up-Regulates Goblet-Specific Gene MUC2 in Concert With CDX2 in Human Esophageal Cells. Arch Surg. 2007, 142 (6): 540-545. 10.1001/archsurg.142.6.540.
Article
CAS
PubMed
Google Scholar
Li B, Cheung PY, Wang X, Tsao SW, Ling MT, Wong YC, Cheung ALM: Id-1 activation of PI3K/Akt/NF{kappa}B signaling pathway and its significance in promoting survival of esophageal cancer cells. Carcinogenesis. 2007, 28 (11): 2313-2320. 10.1093/carcin/bgm152.
Article
CAS
PubMed
Google Scholar
Li J, Minnich DJ, Camp ER, Brank A, Mackay SL, Hochwald SN: Enhanced sensitivity to chemotherapy in esophageal cancer through inhibition of NF-kappaB. The Journal of surgical research. 2006, 132 (1): 112-120. 10.1016/j.jss.2005.10.005.
Article
CAS
PubMed
Google Scholar
Abdel-Latif MM, O'Riordan J, Windle HJ, Carton E, Ravi N, Kelleher D, Reynolds JV: NF-kappaB activation in esophageal adenocarcinoma: relationship to Barrett's metaplasia, survival, and response to neoadjuvant chemoradiotherapy. Annals of surgery. 2004, 239 (4): 491-500. 10.1097/01.sla.0000118751.95179.c6.
Article
PubMed
PubMed Central
Google Scholar
Karin M, Ben-Neriah Y: Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity. Annual Review of Immunology. 2000, 18 (1): 621-663. 10.1146/annurev.immunol.18.1.621.
Article
CAS
PubMed
Google Scholar
Azzaroli F, Mehal W, Soroka CJ, Wang L, Lee J, Crispe N, Boyer JL: Ursodeoxycholic acid diminishes Fas-ligand-induced apoptosis in mouse hepatocytes. Hepatology (Baltimore, Md). 2002, 36 (1): 49-54. 10.1053/jhep.2002.34511.
Article
CAS
Google Scholar
Ahn DH, Crawley SC, Hokari R, Kato S, Yang SC, Li JD, Kim YS: TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation. Cell Physiol Biochem. 2005, 15 (1–4): 29-40. 10.1159/000083636.
Article
CAS
PubMed
Google Scholar
Perrais M, Pigny P, Copin M-C, Aubert J-P, Van Seuningen I: Induction of MUC2 and MUC5AC Mucins by Factors of the Epidermal Growth Factor (EGF) Family Is Mediated by EGF Receptor/Ras/Raf/Extracellular Signal-regulated Kinase Cascade and Sp1*. J Biol Chem. 2002, 277 (35): 32258-32267. 10.1074/jbc.M204862200.
Article
CAS
PubMed
Google Scholar
Yamamoto H, Bai YQ, Yuasa Y: Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem Biophys Res Commun. 2003, 300 (4): 813-818. 10.1016/S0006-291X(02)02935-2.
Article
CAS
PubMed
Google Scholar
Ren CY, Akiyama Y, Miyake S, Yuasa Y: Transcription factor GATA-5 selectively up-regulates mucin gene expression. J Cancer Res Clin Oncol. 2004, 130 (5): 245-252. 10.1007/s00432-003-0537-4.
Article
CAS
PubMed
Google Scholar