Rybak SM, Newton DL: Natural and engineered cytotoxic ribonucleases: therapeutic potential. Exp Cell Res. 1999, 253 (2): 325-335. 10.1006/excr.1999.4718.
Article
CAS
PubMed
Google Scholar
Darzynkiewicz Z, Carter SP, Mikulski SM, Ardelt WJ, Shogen K: Cytostatic and cytotoxic effects of Pannon (P-30 Protein), a novel anticancer agent. Cell Tissue Kinet. 1988, 21 (3): 169-182.
CAS
PubMed
Google Scholar
Ardelt W, Shogen K, Darzynkiewicz Z: Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes. Curr Pharm Biotechnol. 2008, 9 (3): 215-225. 10.2174/138920108784567245.
Article
CAS
PubMed
PubMed Central
Google Scholar
Costanzi J, Sidransky D, Navon A, Goldsweig H: Ribonucleases as a novel pro-apoptotic anticancer strategy: review of the preclinical and clinical data for ranpirnase. Cancer Invest. 2005, 23 (7): 643-650. 10.1080/07357900500283143.
Article
CAS
PubMed
Google Scholar
Wu Y, Mikulski SM, Ardelt W, Rybak SM, Youle RJ: A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity. J Biol Chem. 1993, 268 (14): 10686-10693.
CAS
PubMed
Google Scholar
Ita M, Halicka HD, Tanaka T, Kurose A, Ardelt B, Shogen K, Darzynkiewicz Z: Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines. Cancer Biol Ther. 2008, 7 (7): 1104-1108. 10.4161/cbt.7.7.6172.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vasandani VM, Wu YN, Mikulski SM, Youle RJ, Sung C: Molecular determinants in the plasma clearance and tissue distribution of ribonucleases of the ribonuclease A superfamily. Cancer Res. 1996, 56 (18): 4180-4186.
CAS
PubMed
Google Scholar
Vasandani VM, Burris JA, Sung C: Reversible nephrotoxicity of onconase and effect of lysine pH on renal onconase uptake. Cancer Chemother Pharmacol. 1999, 44 (2): 164-169. 10.1007/s002800050962.
Article
CAS
PubMed
Google Scholar
Leland PA, Staniszewski KE, Kim BM, Raines RT: Endowing human pancreatic ribonuclease with toxicity for cancer cells. J Biol Chem. 2001, 276 (46): 43095-43102. 10.1074/jbc.M106636200.
Article
CAS
PubMed
Google Scholar
Bosch M, Benito A, Ribo M, Puig T, Beaumelle B, Vilanova M: A nuclear localization sequence endows human pancreatic ribonuclease with cytotoxic activity. Biochemistry. 2004, 43 (8): 2167-2177. 10.1021/bi035729+.
Article
CAS
PubMed
Google Scholar
Rodriguez M, Benito A, Tubert P, Castro J, Ribo M, Beaumelle B, Vilanova M: A cytotoxic ribonuclease variant with a discontinuous nuclear localization signal constituted by basic residues scattered over three areas of the molecule. J Mol Biol. 2006, 360 (3): 548-557. 10.1016/j.jmb.2006.05.048.
Article
CAS
PubMed
Google Scholar
Tubert P, Rodriguez M, Ribo M, Benito A, Vilanova M: The nuclear transport capacity of a human-pancreatic ribonuclease variant is critical for its cytotoxicity. Invest New Drugs. 2010
Google Scholar
Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ: Cancer statistics, 2009. CA Cancer J Clin. 2009, 59 (4): 225-249. 10.3322/caac.20006.
Article
PubMed
Google Scholar
Ozols RF, Bundy BN, Greer BE, Fowler JM, Clarke-Pearson D, Burger RA, Mannel RS, DeGeest K, Hartenbach EM, Baergen R: Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a Gynecologic Oncology Group study. J Clin Oncol. 2003, 21 (17): 3194-3200. 10.1200/JCO.2003.02.153.
Article
CAS
PubMed
Google Scholar
Kelley SK, Ashkenazi A: Targeting death receptors in cancer with Apo2L/TRAIL. Curr Opin Pharmacol. 2004, 4 (4): 333-339. 10.1016/j.coph.2004.02.006.
Article
CAS
PubMed
Google Scholar
Leland PA, Schultz LW, Kim BM, Raines RT: Ribonuclease A variants with potent cytotoxic activity. Proc Natl Acad Sci USA. 1998, 95 (18): 10407-10412. 10.1073/pnas.95.18.10407.
Article
CAS
PubMed
PubMed Central
Google Scholar
Canals A, Ribo M, Benito A, Bosch M, Mombelli E, Vilanova M: Production of engineered human pancreatic ribonucleases, solving expression and purification problems, and enhancing thermostability. Protein Expr Purif. 1999, 17 (1): 169-181. 10.1006/prep.1999.1112.
Article
CAS
PubMed
Google Scholar
Ribo M, Benito A, Canals A, Nogues MV, Cuchillo CM, Vilanova M: Purification of engineered human pancreatic ribonuclease. Methods Enzymol. 2001, 341: 221-234. 10.1016/S0076-6879(01)41154-2.
Article
CAS
PubMed
Google Scholar
Ribo M, Bosch M, Torrent G, Benito A, Beaumelle B, Vilanova M: Quantitative analysis, using MALDI-TOF mass spectrometry, of the N-terminal hydrolysis and cyclization reactions of the activation process of onconase. Eur J Biochem. 2004, 271 (6): 1163-1171. 10.1111/j.1432-1033.2004.04020.x.
Article
CAS
PubMed
Google Scholar
Pace CN, Vajdos F, Fee L, Grimsley G, Gray T: How to measure and predict the molar absorption coefficient of a protein. Protein Sci. 1995, 4 (11): 2411-2423. 10.1002/pro.5560041120.
Article
CAS
PubMed
PubMed Central
Google Scholar
Benito A, Ribo M, Vilanova M: On the track of antitumour ribonucleases. Mol Biosyst. 2005, 1 (4): 294-302. 10.1039/b502847g.
Article
CAS
PubMed
Google Scholar
Liu J, Lin A: Role of JNK activation in apoptosis: a double-edged sword. Cell Res. 2005, 15 (1): 36-42. 10.1038/sj.cr.7290262.
Article
PubMed
Google Scholar
Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W, Leisten JC, Motiwala A, Pierce S, Satoh Y, et al: SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA. 2001, 98 (24): 13681-13686. 10.1073/pnas.251194298.
Article
CAS
PubMed
PubMed Central
Google Scholar
Matlashewski G, Banks L, Pim D, Crawford L: Analysis of human p53 proteins and mRNA levels in normal and transformed cells. Eur J Biochem. 1986, 154 (3): 665-672. 10.1111/j.1432-1033.1986.tb09449.x.
Article
CAS
PubMed
Google Scholar
Ogretmen B, Safa AR: Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells. Oncogene. 1997, 14 (4): 499-506. 10.1038/sj.onc.1200855.
Article
CAS
PubMed
Google Scholar
Batist G, Tulpule A, Sinha BK, Katki AG, Myers CE, Cowan KH: Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. J Biol Chem. 1986, 261 (33): 15544-15549.
CAS
PubMed
Google Scholar
Gehrmann ML, Fenselau C, Hathout Y: Highly altered protein expression profile in the adriamycin resistant MCF-7 cell line. J Proteome Res. 2004, 3 (3): 403-409. 10.1021/pr0340577.
Article
CAS
PubMed
Google Scholar
Shi Z, Liang YJ, Chen ZS, Wang XH, Ding Y, Chen LM, Fu LW: Overexpression of Survivin and XIAP in MDR cancer cells unrelated to P-glycoprotein. Oncol Rep. 2007, 17 (4): 969-976.
CAS
PubMed
Google Scholar
Iordanov MS, Ryabinina OP, Wong J, Dinh TH, Newton DL, Rybak SM, Magun BE: Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis. Cancer Res. 2000, 60 (7): 1983-1994.
CAS
PubMed
Google Scholar
Haigis MC, Kurten EL, Raines RT: Ribonuclease inhibitor as an intracellular sentry. Nucleic Acids Res. 2003, 31 (3): 1024-1032. 10.1093/nar/gkg163.
Article
CAS
PubMed
PubMed Central
Google Scholar
Grabarek J, Ardelt B, Du L, Darzynkiewicz Z: Activation of caspases and serine proteases during apoptosis induced by onconase (Ranpirnase). Exp Cell Res. 2002, 278 (1): 61-71. 10.1006/excr.2002.5568.
Article
CAS
PubMed
Google Scholar
Michaelis M, Cinatl J, Anand P, Rothweiler F, Kotchetkov R, von Deimling A, Doerr HW, Shogen K, Cinatl J: Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells. Cancer Lett. 2007, 250 (1): 107-116. 10.1016/j.canlet.2006.09.018.
Article
CAS
PubMed
Google Scholar
Ardelt B, Juan G, Burfeind P, Salomon T, Wu JM, Hsieh TC, Li X, Sperry R, Pozarowski P, Shogen K, et al: Onconase, an anti-tumor ribonuclease suppresses intracellular oxidative stress. Int J Oncol. 2007, 31 (3): 663-669.
CAS
PubMed
Google Scholar
Jacotot E, Ferri KF, Kroemer G: Apoptosis and cell cycle: distinct checkpoints with overlapping upstream control. Pathol Biol (Paris). 2000, 48 (3): 271-279.
CAS
Google Scholar
Ye F, Che Y, McMillen E, Gorski J, Brodman D, Saw D, Jiang B, Zhang DY: The effect of Scutellaria baicalensis on the signaling network in hepatocellular carcinoma cells. Nutr Cancer. 2009, 61 (4): 530-537. 10.1080/01635580902803719.
Article
CAS
PubMed
Google Scholar
Takezawa K, Okamoto I, Tsukioka S, Uchida J, Kiniwa M, Fukuoka M, Nakagawa K: Identification of thymidylate synthase as a potential therapeutic target for lung cancer. Br J Cancer. 2010, 103 (3): 354-361. 10.1038/sj.bjc.6605793.
Article
CAS
PubMed
PubMed Central
Google Scholar
Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ: The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993, 75 (4): 805-816. 10.1016/0092-8674(93)90499-G.
Article
CAS
PubMed
Google Scholar
Waga S, Hannon GJ, Beach D, Stillman B: The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature. 1994, 369 (6481): 574-578. 10.1038/369574a0.
Article
CAS
PubMed
Google Scholar
Niculescu AB, Chen X, Smeets M, Hengst L, Prives C, Reed SI: Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol. 1998, 18 (1): 629-643.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ogryzko VV, Wong P, Howard BH: WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases. Mol Cell Biol. 1997, 17 (8): 4877-4882.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ameyar M, Shatrov V, Bouquet C, Capoulade C, Cai Z, Stancou R, Badie C, Haddada H, Chouaib S: Adenovirus-mediated transfer of wild-type p53 gene sensitizes TNF resistant MCF7 derivatives to the cytotoxic effect of this cytokine: relationship with c-myc and Rb. Oncogene. 1999, 18 (39): 5464-5472. 10.1038/sj.onc.1202919.
Article
CAS
PubMed
Google Scholar
Dvory-Sobol H, Cohen-Noyman E, Kazanov D, Figer A, Birkenfeld S, Madar-Shapiro L, Benamouzig R, Arber N: Celecoxib leads to G2/M arrest by induction of p21 and down-regulation of cyclin B1 expression in a p53-independent manner. Eur J Cancer. 2006, 42 (3): 422-426. 10.1016/j.ejca.2005.11.009.
Article
CAS
PubMed
Google Scholar
Suzuki T, Yokozaki H, Kuniyasu H, Hayashi K, Naka K, Ono S, Ishikawa T, Tahara E, Yasui W: Effect of trichostatin A on cell growth and expression of cell cycle- and apoptosis-related molecules in human gastric and oral carcinoma cell lines. Int J Cancer. 2000, 88 (6): 992-997. 10.1002/1097-0215(20001215)88:6<992::AID-IJC24>3.0.CO;2-9.
Article
CAS
PubMed
Google Scholar
Goke R, Goke A, Goke B, El-Deiry WS, Chen Y: Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21waf1/cip1. Digestion. 2001, 64 (2): 75-80. 10.1159/000048843.
Article
CAS
PubMed
Google Scholar
Lincet H, Poulain L, Remy JS, Deslandes E, Duigou F, Gauduchon P, Staedel C: The p21(cip1/waf1) cyclin-dependent kinase inhibitor enhances the cytotoxic effect of cisplatin in human ovarian carcinoma cells. Cancer Lett. 2000, 161 (1): 17-26. 10.1016/S0304-3835(00)00586-3.
Article
CAS
PubMed
Google Scholar
Shim J, Lee H, Park J, Kim H, Choi EJ: A non-enzymatic p21 protein inhibitor of stress-activated protein kinases. Nature. 1996, 381 (6585): 804-806. 10.1038/381804a0.
Article
CAS
PubMed
Google Scholar
Potapova O, Gorospe M, Dougherty RH, Dean NM, Gaarde WA, Holbrook NJ: Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol Cell Biol. 2000, 20 (5): 1713-1722. 10.1128/MCB.20.5.1713-1722.2000.
Article
CAS
PubMed
PubMed Central
Google Scholar
Du L, Lyle CS, Obey TB, Gaarde WA, Muir JA, Bennett BL, Chambers TC: Inhibition of cell proliferation and cell cycle progression by specific inhibition of basal JNK activity: evidence that mitotic Bcl-2 phosphorylation is JNK-independent. J Biol Chem. 2004, 279 (12): 11957-11966. 10.1074/jbc.M304935200.
Article
CAS
PubMed
Google Scholar
Ennis BW, Fultz KE, Smith KA, Westwick JK, Zhu D, Boluro-Ajayi M, Bilter GK, Stein B: Inhibition of tumor growth, angiogenesis, and tumor cell proliferation by a small molecule inhibitor of c-Jun N-terminal kinase. J Pharmacol Exp Ther. 2005, 313 (1): 325-332. 10.1124/jpet.104.078873.
Article
CAS
PubMed
Google Scholar
Iordanov MS, Wong J, Newton DL, Rybak SM, Bright RK, Flavell RA, Davis RJ, Magun BE: Differential requirement for the stress-activated protein kinase/c-Jun NH(2)-terminal kinase in RNAdamage-induced apoptosis in primary and in immortalized fibroblasts. Mol Cell Biol Res Commun. 2000, 4 (2): 122-128. 10.1006/mcbr.2000.0266.
Article
CAS
PubMed
Google Scholar
Smith MR, Newton DL, Mikulski SM, Rybak SM: Cell cycle-related differences in susceptibility of NIH/3T3 cells to ribonucleases. Exp Cell Res. 1999, 247 (1): 220-232. 10.1006/excr.1998.4317.
Article
CAS
PubMed
Google Scholar
Tsai SY, Ardelt B, Hsieh TC, Darzynkiewicz Z, Shogen K, Wu JM: Treatment of Jurkat acute T-lymphocytic leukemia cells by onconase (Ranpirnase) is accompanied by an altered nucleocytoplasmic distribution and reduced expression of transcription factor NF-kappaB. Int J Oncol. 2004, 25 (6): 1745-1752.
CAS
PubMed
Google Scholar
Zhao H, Ardelt B, Ardelt W, Shogen K, Darzynkiewicz Z: The cytotoxic ribonuclease onconase targets RNA interference (siRNA). Cell Cycle. 2008, 7 (20): 3258-3261.
Article
CAS
PubMed
PubMed Central
Google Scholar
Montanaro L, Trere D, Derenzini M: Nucleolus, ribosomes, and cancer. Am J Pathol. 2008, 173 (2): 301-310. 10.2353/ajpath.2008.070752.
Article
CAS
PubMed
PubMed Central
Google Scholar