Figure 1

Proliferation and viability curves of NCI/ADR-RES cells treated with PE5 or onconase. Cells were treated with 0 (black circle), 2 (white circle), 7 (black triangle), 14 (white triangle) and 35 μM (black square) of PE5 (A and C) or 0 (black circle), 0.3 (white circle), 1 (black triangle), 2 (white triangle) and 5 μM (black square) of onconase (B and D). Trypan blue dye exclusion cell viability was estimated at 0, 24, 48 and 72 h after administration of the RNases. The plotted points represent means of at least three independent experiments.