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  1. Tumor microenvironment is composed of tumor cells, fibroblasts, endothelial cells, and infiltrating immune cells. Tumor-associated immune cells may inhibit or promote tumor growth and progression. This study w...

    Authors: Fuqiang Dai, Lunxu Liu, Guowei Che, Nanbin Yu, Qiang Pu, Shangfu Zhang, Junliang Ma, Lin Ma and Zongbing You
    Citation: BMC Cancer 2010 10:220
    Content type: Research article Published on:

  2. The opposite effects of chemotherapy, which enhance the malignancy of treated cancers such as hepatocellular carcinoma (HCC), are not well understood. We investigated this phenomenon and corresponding mechanis...

    Authors: Wei Xiong, Zheng-Gang Ren, Shuang-Jian Qiu, Hui-Chuan Sun, Lu Wang, Bin-Bin Liu, Qi-Song Li, Wei Zhang, Xiao-Dong Zhu, Liang Liu, Wen-Quan Wang and Zhao-You Tang
    Citation: BMC Cancer 2010 10:219
    Content type: Research article Published on:

  3. Rapid and effective treatment of cancer-induced bone pain remains a clinical challenge and patients with bone metastasis are more likely to experience severe pain. The voltage-gated sodium channel Nav1.8 plays...

    Authors: Xue-Rong Miao, Xiao-Fei Gao, Jing-Xiang Wu, Zhi-Jie Lu, Zhang-Xiang Huang, Xiao-Qing Li, Cheng He and Wei-Feng Yu
    Citation: BMC Cancer 2010 10:216
    Content type: Research article Published on:

  4. Malignant glioma is a rare cancer with poor survival. The influence of diet and antioxidant intake on glioma survival is not well understood. The current study examines the association between antioxidant inta...

    Authors: Gerald N DeLorenze, Lucie McCoy, Ai-Lin Tsai, Charles P Quesenberry Jr, Terri Rice, Dora Il'yasova and Margaret Wrensch
    Citation: BMC Cancer 2010 10:215
    Content type: Research article Published on:

  5. Data from the California Health Interview Survey (CHIS) indicate that levels and temporal trends in colorectal cancer (CRC) screening prevalence vary among Asian American groups; however, the reasons for these...

    Authors: Annette E Maxwell, Catherine M Crespi, Cynthia M Antonio and Peiyun Lu
    Citation: BMC Cancer 2010 10:214
    Content type: Research article Published on:

  6. Griseofulvin, an antifungal drug, has recently been shown to inhibit proliferation of various types of cancer cells and to inhibit tumor growth in athymic mice. Due to its low toxicity, griseofulvin has drawn ...

    Authors: Krishnan Rathinasamy, Bhavya Jindal, Jayant Asthana, Parminder Singh, Petety V Balaji and Dulal Panda
    Citation: BMC Cancer 2010 10:213
    Content type: Research article Published on:

  7. The calcium-permeable cation channel TRPM8 (melastatin-related transient receptor potential member 8) is over-expressed in several cancers. The present study aimed at investigating the expression, function and...

    Authors: Dechen Chodon, Arnaud Guilbert, Isabelle Dhennin-Duthille, Mathieu Gautier, Marie-Sophie Telliez, Henri Sevestre and Halima Ouadid-Ahidouch
    Citation: BMC Cancer 2010 10:212
    Content type: Research article Published on:

  8. We have studied the in vitro and in vivo utility of polyethylene glycol (PEG)-hydrogels for the development of an anticancer drug 5-fluorouracil (5-FU) delivery system.

    Authors: Hee Yi, Hee-Jung Cho, Soo-Min Cho, Dong-Goo Lee, AM Abd El-Aty, So-Jeong Yoon, Gun-Won Bae, Kwang Nho, Bokyung Kim, Chi-Ho Lee, Jin-Suk Kim, Michael G Bartlett and Ho-Chul Shin
    Citation: BMC Cancer 2010 10:211
    Content type: Research article Published on:

  9. Chemoprevention, which includes the use of synthetic or natural agents (alone or in combination) to block the development of cancer in human beings, is an extremely promising strategy for cancer prevention. Ci...

    Authors: Soumya J Koppikar, Amit S Choudhari, Snehal A Suryavanshi, Shweta Kumari, Samit Chattopadhyay and Ruchika Kaul-Ghanekar
    Citation: BMC Cancer 2010 10:210
    Content type: Research article Published on:

  10. The sole effective option for patients with advanced HCC is sorafenib and there is an urgent need to develop new therapeutic approaches. Immunotherapy is a promising option that deserves major investigation. I...

    Authors: Tim F Greten, Alejandro Forner, Firouzeh Korangy, Gisele N'Kontchou, Nathalie Barget, Carmen Ayuso, Lars A Ormandy, Michael P Manns, Michel Beaugrand and Jordi Bruix
    Citation: BMC Cancer 2010 10:209
    Content type: Research article Published on:

  11. Melanoma usually presents as an initial skin lesion without evidence of metastasis. A significant proportion of patients develop subsequent local, regional or distant metastasis, sometimes many years after the...

    Authors: Maxine S Emmett, Kirsty E Symonds, Howard Rigby, Martin G Cook, Rebecca Price, Chris Metcalfe, Antonio Orlando and David O Bates
    Citation: BMC Cancer 2010 10:208
    Content type: Research article Published on:

  12. One of the most commonly used classes of anti-cancer drugs presently in clinical practice is the platinum-based drugs, including cisplatin. The efficacy of cisplatin therapy is often limited by the emergence o...

    Authors: Lawton J Stubbert, Jennifer M Smith and Bruce C McKay
    Citation: BMC Cancer 2010 10:207
    Content type: Research article Published on:

  13. Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and adolescents. However, the knowledge in diagnostic modalities has progressed less. To identify new biomarkers for the early d...

    Authors: Zhiyu Zhang, Lijun Zhang, Yingqi Hua, Xiaofang Jia, Jian Li, Shuo Hu, Xia Peng, Pengyuan Yang, Mengxiong Sun, Fang Ma and Zhengdong Cai
    Citation: BMC Cancer 2010 10:206
    Content type: Research article Published on:

  14. A population of breast cancer patients exists who, for various reasons, never received adjuvant post-operative tamoxifen (TAM). This study was aimed to evaluate the role of late TAM in these patients.

    Authors: Andrea Veronesi, GianMaria Miolo, Maria D Magri, Diana Crivellari, Simona Scalone, Ettore Bidoli and Davide Lombardi
    Citation: BMC Cancer 2010 10:205
    Content type: Research article Published on:

  15. One of the main obstacles for successful cancer polychemotherapy is multiple drug resistance phenotype (MDR) acquired by tumor cells. Currently, RNA interference represents a perspective strategy to overcome M...

    Authors: Olga A Patutina, Nadezda L Mironova, Nelly A Popova, Vasily I Kaledin, Valery P Nikolin, Valentin V Vlassov and Marina A Zenkova
    Citation: BMC Cancer 2010 10:204
    Content type: Research article Published on:

  16. Angiogenesis is a multistep process in which many growth factors and cytokines have an essential role. Vascular endothelial growth factor (VEGF) is a potent angiogenic agent that acts as a specific mitogen for...

    Authors: Kyung A Kwon, Sung Hyun Kim, Sung Yong Oh, Suee Lee, Jin-Yeong Han, Kyeong Hee Kim, Ri Young Goh, Hong Jo Choi, Ki Jae Park, Mee Sook Roh, Hyo-Jin Kim, Hyuk-Chan Kwon and Jong Hoon Lee
    Citation: BMC Cancer 2010 10:203
    Content type: Research article Published on:

  17. Human osteosarcoma is the most common pediatric bone tumor. There is limited understanding of the molecular mechanisms underlying osteosarcoma oncogenesis, and a lack of good diagnostic as well as prognostic c...

    Authors: Bekim Sadikovic, Paul Thorner, Susan Chilton-MacNeill, Jeff W Martin, Nilva K Cervigne, Jeremy Squire and Maria Zielenska
    Citation: BMC Cancer 2010 10:202
    Content type: Research article Published on:

  18. Seladin-1 overexpression exerts a protective mechanism against apoptosis. Seladin-1 mRNA is variably expressed in normal human tissues. Adrenal glands show the highest levels of seladin-1 expression, which are...

    Authors: Lisa Simi, Francesca Malentacchi, Paola Luciani, Stefania Gelmini, Cristiana Deledda, Rosaria Arvia, Massimo Mannelli, Alessandro Peri and Claudio Orlando
    Citation: BMC Cancer 2010 10:201
    Content type: Research article Published on:

  19. Phagocytosis of apoptotic cells by macrophages induces a suppressor phenotype. Previous data from our group suggested that this occurs via Platelet-activating factor receptor (PAF-R)-mediated pathways. In the ...

    Authors: Soraya I de Oliveira, Luciana NS Andrade, Ana C Onuchic, Sueli Nonogaki, Patrícia D Fernandes, Mônica C Pinheiro, Ciro BS Rohde, Roger Chammas and Sonia Jancar
    Citation: BMC Cancer 2010 10:200
    Content type: Research article Published on:

  20. About 80% of patients with GIST would experience tumor recurrence or metastasis after radical resection. The most common site of the metastasis is the liver. Imatinib mesylate has been proved effective for adv...

    Authors: Jiang Zhu, Yu Yang, Lin Zhou, Ming Jiang and Mei Hou
    Citation: BMC Cancer 2010 10:199
    Content type: Research article Published on:

  21. Multiple myeloma (MM) is characterized by a strong dependence of the tumor cells on their microenvironment, which produces growth factors supporting survival and proliferation of myeloma cells (MMC). In the pa...

    Authors: Karène Mahtouk, Jérôme Moreaux, Dirk Hose, Thierry Rème, Tobias Meißner, Michel Jourdan, Jean François Rossi, Steven T Pals, Hartmut Goldschmidt and Bernard Klein
    Citation: BMC Cancer 2010 10:198
    Content type: Research article Published on:

  22. Coactivator-associated arginine methyltransferase 1 (CARM1) functions as a transcriptional coactivator of androgen receptor (AR)-mediated signaling. Correspondingly, overexpression of CARM1 has been associated...

    Authors: Young-Rang Kim, Byung Kook Lee, Ra-Young Park, Nguyen Thi Xuan Nguyen, Jeong A Bae, Dong Deuk Kwon and Chaeyong Jung
    Citation: BMC Cancer 2010 10:197
    Content type: Research article Published on:

  23. Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma are two distinct but closely related entities with strong morphologic and genetic similarities. While chRCC is a malignant tumor, oncocytoma is usu...

    Authors: Min-Han Tan, Chin Fong Wong, Hwei Ling Tan, Ximing J Yang, Jonathon Ditlev, Daisuke Matsuda, Sok Kean Khoo, Jun Sugimura, Tomoaki Fujioka, Kyle A Furge, Eric Kort, Sophie Giraud, Sophie Ferlicot, Philippe Vielh, Delphine Amsellem-Ouazana, Bernard Debré…
    Citation: BMC Cancer 2010 10:196
    Content type: Research article Published on:

  24. Loss of heterozygosity (LOH) is an important marker for one of the 'two-hits' required for tumor suppressor gene inactivation. Traditional methods for mapping LOH regions require the comparison of both tumor a...

    Authors: Michael R Green, Paul Jardine, Peter Wood, Jeremy Wellwood, Rod A Lea, Paula Marlton and Lyn R Griffiths
    Citation: BMC Cancer 2010 10:195
    Content type: Technical advance Published on:

  25. Azoxymethane (AOM) or 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis in rats shares many phenotypical similarities with human sporadic colon cancer and is a reliable model for identifying chemopreven...

    Authors: Angelo Pietro Femia, Cristina Luceri, Simona Toti, Augusto Giannini, Piero Dolara and Giovanna Caderni
    Citation: BMC Cancer 2010 10:194
    Content type: Research article Published on:

  26. Cell-surface glycoproteins play critical roles in cell-to-cell recognition, signal transduction and regulation, thus being crucial in cell proliferation and cancer etiogenesis and development. DPP IV and NEP a...

    Authors: Adolfo Varona, Lorena Blanco, Itxaro Perez, Javier Gil, Jon Irazusta, José I López, M Luz Candenas, Francisco M Pinto and Gorka Larrinaga
    Citation: BMC Cancer 2010 10:193
    Content type: Research article Published on:

  27. Activator Protein-2 (AP-2) transcription factors are critically involved in a variety of fundamental cellular processes such as proliferation, differentiation and apoptosis and have also been implicated in car...

    Authors: Verena Thewes, Francesca Orso, Richard Jäger, Dawid Eckert, Sabine Schäfer, Gregor Kirfel, Stephan Garbe, Daniela Taverna and Hubert Schorle
    Citation: BMC Cancer 2010 10:192
    Content type: Research article Published on:

  28. Recent reports suggest increase in estrogen receptor (ER), progesterone receptor (PR) negative breast cancer yet little is known about histology or receptor status of breast cancer in Indian/Pakistani women.in...

    Authors: Madhuri Kakarala, Laura Rozek, Michele Cote, Samadhi Liyanage and Dean E Brenner
    Citation: BMC Cancer 2010 10:191
    Content type: Research article Published on:

  29. The potential anti-cancer effects of mammalian target of rapamycin (mTOR) inhibitors are being intensively studied. To date, however, few randomised clinical trials (RCT) have been performed to demonstrate ant...

    Authors: Andreas A Schnitzbauer, Carl Zuelke, Christian Graeb, Justine Rochon, Itxarone Bilbao, Patrizia Burra, Koert P de Jong, Christophe Duvoux, Norman M Kneteman, Rene Adam, Wolf O Bechstein, Thomas Becker, Susanne Beckebaum, Olivier Chazouillères, Umberto Cillo, Michele Colledan…
    Citation: BMC Cancer 2010 10:190
    Content type: Study protocol Published on:

  30. With the availability of effective anti-EGFR therapies for various solid malignancies, such as non-cell small lung cancer, colorectal cancer and squamous cell carcinoma of the head and neck, the knowledge of EGFR

    Authors: Nancy Van Damme, Philippe Deron, Nadine Van Roy, Pieter Demetter, Alain Bols, Jo Van Dorpe, Filip Baert, Jean-Luc Van Laethem, Franki Speleman, Patrick Pauwels and Marc Peeters
    Citation: BMC Cancer 2010 10:189
    Content type: Research article Published on:

  31. There is strong evidence demonstrating that activation of epidermal growth factor receptors (EGFRs) leads to tumor growth, progression, invasion and metastasis. Erlotinib and gefitinib, two EGFR-targeted agent...

    Authors: Roque Diaz, Paul A Nguewa, Ricardo Parrondo, Carlos Perez-Stable, Irene Manrique, Miriam Redrado, Raul Catena, Maria Collantes, Ivan Peñuelas, Juan Antonio Díaz-González and Alfonso Calvo
    Citation: BMC Cancer 2010 10:188
    Content type: Research article Published on:

  32. The activation of signal transducer and activator of transcription 3 (Stat3) pathway correlates with tumor growth, survival, drug resistance and poor prognosis in osteosarcoma. To explore the potential therape...

    Authors: Keinosuke Ryu, Michiro Susa, Edwin Choy, Cao Yang, Francis J Hornicek, Henry J Mankin and Zhenfeng Duan
    Citation: BMC Cancer 2010 10:187
    Content type: Research article Published on:

  33. Bcl-2 promotes cell survival by inhibiting adapters needed for the activation and cleavage of caspases thus blocking the proteolytic cascade that ultimately dismantles the cell. Bcl-2 has been investigated as ...

    Authors: Valsamo K Anagnostou, Frank J Lowery, Vassiliki Zolota, Vassiliki Tzelepi, Arun Gopinath, Camil Liceaga, Nikolaos Panagopoulos, Konstantina Frangia, Lynn Tanoue, Daniel Boffa, Scott Gettinger, Frank Detterbeck, Robert J Homer, Dimitrios Dougenis, David L Rimm and Konstantinos N Syrigos
    Citation: BMC Cancer 2010 10:186
    Content type: Research article Published on:

  34. Tissue inhibitor of metalloproteinase 1 (TIMP-1) is a natural inhibitor of the matrix metalloproteinases (MMPs) which are proteolytic enzymes involved in degradation of extracellular matrix thereby favoring tu...

    Authors: Karina Dahl Steffensen, Marianne Waldstrøm, Rikke Kølby Christensen, Annette Bartels, Nils Brünner and Anders Jakobsen
    Citation: BMC Cancer 2010 10:185
    Content type: Research article Published on:

  35. Insulin-like growth factor-I receptor (IGFIR) has been shown to regulate the tumor development. The objective of the current study is to determine the association of IGFIR with lymph node metastasis and to exp...

    Authors: Chunhui Zhang, Li Hao, Liang Wang, Yichuan Xiao, Hailiang Ge, Zhenya Zhu, Yunbao Luo, Yi Zhang and Yanyun Zhang
    Citation: BMC Cancer 2010 10:184
    Content type: Research article Published on:

  36. The formation of metastases includes the separation of tumor cells from the primary tumor, cell migration into subendothelial tissue and cell proliferation in secondary organ. In this process, cell adhesion of...

    Authors: Walburgis Brenner, Silke Beitz, Elke Schneider, Frank Benzing, Ronald E Unger, Frederik C Roos, Joachim W Thüroff and Christian Hampel
    Citation: BMC Cancer 2010 10:183
    Content type: Research article Published on:

  37. Although chromosomal instability (CIN) has been detected in many kinds of human malignancies by means of various methods, there is no practical assessment for small clinical specimens. In this study, we evalua...

    Authors: Hiroaki Sato, Narikazu Uzawa, Ken-Ichiro Takahashi, Kunihiro Myo, Yoshio Ohyama and Teruo Amagasa
    Citation: BMC Cancer 2010 10:182
    Content type: Research article Published on:

  38. Neuroblastoma has successfully served as a model system for the identification of neuroectoderm-derived oncogenes. However, in spite of various efforts, only a few clinically useful prognostic markers have bee...

    Authors: Maija Wolf, Miikka Korja, Ritva Karhu, Henrik Edgren, Sami Kilpinen, Kalle Ojala, Spyro Mousses, Anne Kallioniemi and Hannu Haapasalo
    Citation: BMC Cancer 2010 10:181
    Content type: Research article Published on:

  39. To investigate the etiology of MLH1 promoter methylation in mismatch repair (MMR) mutation-negative early onset MSI-H colon cancer. As this type of colon cancer is associated with high ages, young patients bearin...

    Authors: Eddy HJ van Roon, Marjo van Puijenbroek, Anneke Middeldorp, Ronald van Eijk, Emile J de Meijer, Dianhdra Erasmus, Kim AD Wouters, Manon van Engeland, Jan Oosting, Frederik J Hes, Carli MJ Tops, Tom van Wezel, Judith M Boer and Hans Morreau
    Citation: BMC Cancer 2010 10:180
    Content type: Research article Published on:

  40. Spontaneous regression/complete resistance (SR/CR) mice are a unique colony of mice that possess an inheritable, natural cancer resistance mediated primarily by innate cellular immunity. This resistance is eff...

    Authors: Gregory Riedlinger, Jonathan Adams, John R Stehle Jr, Michael J Blanks, Anne M Sanders, Amy M Hicks, Mark C Willingham and Zheng Cui
    Citation: BMC Cancer 2010 10:179
    Content type: Research article Published on:

  41. Suppressors of cytokine signaling (SOCS) are important negative feedback regulators of the JAK/STAT signaling pathway, and have been recently investigated for their role in the development of different cancers...

    Authors: Walid Sasi, Wen G Jiang, Anup Sharma and Kefah Mokbel
    Citation: BMC Cancer 2010 10:178
    Content type: Research article Published on:

  42. Metastasis formation is the leading cause of death among colon cancer patients. We established a new in-situ model of in vivo microscopy of the lung to analyse initiating events of metastatic tumor cell adhesi...

    Authors: Peter Gassmann, Mi-Li Kang, Soeren T Mees and Joerg Haier
    Citation: BMC Cancer 2010 10:177
    Content type: Research article Published on:

  43. Metastasis is a major cancer-related cause of death. Recent studies have described metastasis pathways. However, the exact contribution of each pathway remains unclear. Another key feature of a tumor is the pr...

    Authors: Michael Pierre, Benoît DeHertogh, Anthoula Gaigneaux, Bertrand DeMeulder, Fabrice Berger, Eric Bareke, Carine Michiels and Eric Depiereux
    Citation: BMC Cancer 2010 10:176
    Content type: Research article Published on:

  44. Advanced cancer is a multifactorial disease that demands treatments targeting multiple cellular pathways. Chinese herbal cocktail which contains various phytochemicals may target multiple dys-regulated pathway...

    Authors: Jean-San Chia, Jia-Ling Du, Wei-Bin Hsu, Andy Sun, Chun-Pin Chiang and Won-Bo Wang
    Citation: BMC Cancer 2010 10:175
    Content type: Research article Published on:

  45. Current frequent follow-up after treatment for breast cancer does not meet its intended aims, but does depend on expensive and scarce specialized knowledge for routine history taking and physical examinations....

    Authors: Merel L Kimman, Monique MF Bloebaum, Carmen D Dirksen, Ruud MA Houben, Philippe Lambin and Liesbeth J Boersma
    Citation: BMC Cancer 2010 10:174
    Content type: Research article Published on:

  46. Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often validated using reverse transcription quant...

    Authors: Kah Hoong Chang, Pieter Mestdagh, Jo Vandesompele, Michael J Kerin and Nicola Miller
    Citation: BMC Cancer 2010 10:173
    Content type: Research article Published on:

  47. We have previously demonstrated that tumour islet infiltration by macrophages is associated with extended survival (ES) in NSCLC. We therefore hypothesised that patients with improved survival would have high ...

    Authors: Chandra M Ohri, Aarti Shikotra, Ruth H Green, David A Waller and Peter Bradding
    Citation: BMC Cancer 2010 10:172
    Content type: Research article Published on:

  48. The management of early breast cancer (BC) with skin-sparing mastectomy (SSM) and immediate breast reconstruction (IBR) is not based on level-1 evidence. In this study, the oncological outcome, post-operative ...

    Authors: Sara Reefy, Neill Patani, Anne Anderson, Gwyne Burgoyne, Hisham Osman and Kefah Mokbel
    Citation: BMC Cancer 2010 10:171
    Content type: Research article Published on:

  49. The elevated expression of vascular endothelial growth factor C (VEGF-C) is correlated with clinical cervical cancer metastasis and patient survival, which is interpreted by VEGF-C functions to stimulate angio...

    Authors: Mian He, Yang Cheng, Wen Li, Qiongshan Liu, Junxiu Liu, Jinghe Huang and Xiaodong Fu
    Citation: BMC Cancer 2010 10:170
    Content type: Research article Published on:

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