Center MM, Jemal A, Ward E: International trends in colorectal cancer incidence rates. Cancer Epidemiol Biomarkers Prev. 2009, 18: 1688-94. 10.1158/1055-9965.EPI-09-0090.
Article
PubMed
Google Scholar
Femia AP, Caderni G: Rodent models of colon carcinogenesis for the study of chemopreventive activity of natural products. Planta Med. 2008, 74: 1602-7. 10.1055/s-2008-1074577.
Article
CAS
PubMed
Google Scholar
Corpet DE, Pierre F: How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men. Eur J Cancer. 2005, 4: 1911-22. 10.1016/j.ejca.2005.06.006.
Article
Google Scholar
Cardoso J, Boer J, Morreau H, Fodde R: Expression and genomic profiling of colorectal cancer. Biochim Biophys Acta. 2007, 1775: 103-37.
CAS
PubMed
Google Scholar
Nambiar PR, Nakanishi M, Gupta R, Cheung E, Firouzi A, Ma XJ, Flynn C, Dong M, Guda K, Levine J, Raja R, Achenie L, Rosenberg DW: Genetic signatures of high- and low-risk aberrant crypt foci in a mouse model of sporadic colon cancer. Cancer Res. 2004, 64: 6394-401. 10.1158/0008-5472.CAN-04-0933.
Article
CAS
PubMed
Google Scholar
Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Boivin GP, Roberts RB, Bissahoyo AC, Gonzales F, Bloom GC, Eschrich S, Carter SL, Aronow JE, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden J, Dove WF, Threadgill DW, Yeatman TJ, Coffey RJ, Aronow BJ: Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumour models and human colon cancer. Genome Biol. 2007, 8: R131-10.1186/gb-2007-8-7-r131.
Article
PubMed
PubMed Central
Google Scholar
Luceri C, De Filippo C, Caderni G, Gambacciani L, Salvadori M, Giannini A, Dolara P: Detection of somatic DNA alterations in azoxymethane-induced F344 rat colon tumours by random amplified polymorphic DNA analysis. Carcinogenesis. 2000, 21: 1753-6. 10.1093/carcin/21.9.1753.
Article
CAS
PubMed
Google Scholar
Guda K, Upender MB, Belinsky G, Flynn C, Nakanishi M, Marino JN, Ried T, Rosenberg DW: Carcinogen-induced colon tumours in mice are chromosomally stable and are characterized by low-level microsatellite instability. Oncogene. 2004, 23: 3813-21. 10.1038/sj.onc.1207489.
Article
CAS
PubMed
Google Scholar
Femia AP, Caderni G, Bottini C, Salvadori M, Dolara P, Tessitore L: Mucin-depleted foci are modulated by dietary treatments and show deregulation of proliferative activity in carcinogen-treated rodents. Int J Cancer. 2007, 120: 2301-5. 10.1002/ijc.22145.
Article
CAS
PubMed
Google Scholar
European Community: European community regulations on the care and use of laboratory animals. Law 86/609/EC. 1986
Google Scholar
Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, Salvadori M, Clune Y, Collins KJ, Paglierani M, Caderni G: Antitumourigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis. 2002, 23: 1953-60. 10.1093/carcin/23.11.1953.
Article
CAS
PubMed
Google Scholar
Lodovici M, Luceri C, De Filippo C, Romualdi C, Bambi F, Dolara P: Smokers and passive smokers gene expression profiles: correlation with the DNA oxidation damage. Free Radic Biol Med. 2007, 43: 415-22. 10.1016/j.freeradbiomed.2007.04.018.
Article
CAS
PubMed
Google Scholar
Castagnini C, Luceri C, Toti S, Bigagli E, Caderni G, Femia AP, Giovannelli L, Lodovici M, Pitozzi V, Salvadori M, Messerini L, Martin R, Zoetendal EG, Gaj S, Eijssen L, Evelo CT, Renard CM, Baron A, Dolara P: Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols. Br J Nutr. 2009, 22: 1-9.
Google Scholar
Smyth GK: Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments. Statistical Applications in Genetics and Molecular Biology. 2004, 3 (1): 10.2202/1544-6115.1027. Article 3
Google Scholar
Gene Map Annotator and Pathway Profiler Version 2.1. [http://www.genmapp.org]
Luceri C, Caderni G, Sanna A, Dolara P: Red wine and black tea polyphenols modulate the expression of cycloxygenase-2, inducible nitric oxide synthase and glutathione-related enzymes in azoxymethane-induced F344 rat colon tumours. J Nutr. 2002, 132: 1376-9.
CAS
PubMed
Google Scholar
Van Es JH, Jay P, Gregorieff A, van Gijn ME, Jonkheer S, Hatzis P, Thiele A, Born van den M, Begthel H, Brabletz T, Taketo MM, Clevers H: Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat Cell Biol. 2005, 7: 381-6. 10.1038/ncb1240.
Article
CAS
PubMed
Google Scholar
Flier Van der LG, Clevers H: Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol. 2009, 71: 241-60. 10.1146/annurev.physiol.010908.163145.
Article
PubMed
Google Scholar
Fujiwara K, Ochiai M, Ohta T, Ohki M, Aburatani H, Nagao M, Sugimura T, Nakagama H: Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Carcinogenesis. 2004, 25: 1495-505. 10.1093/carcin/bgh155.
Article
CAS
PubMed
Google Scholar
Flier Van der LG, Sabates-Bellver J, Oving I, Haegebarth A, De Palo M, Anti M, Van Gijn ME, Suijkerbuijk S, Wetering Van de M, Marra G, Clevers H: The Intestinal Wnt/TCF Signature. Gastroenterology. 2007, 132: 628-32. 10.1053/j.gastro.2006.08.039.
Article
PubMed
Google Scholar
Zucker S, Vacirca J: Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev. 2004, 23: 101-17. 10.1023/A:1025867130437.
Article
CAS
PubMed
Google Scholar
Andreasen PA, Kjøller L, Christensen L, Duffy MJ: The urokinase-type plasminogen activator system in cancer metastasis: a review. Int J Cancer. 1997, 72: 1-22. 10.1002/(SICI)1097-0215(19970703)72:1<1::AID-IJC1>3.0.CO;2-Z.
Article
CAS
PubMed
Google Scholar
Kermorgant S, Aparicio T, Dessirier V, Lewin MJ, Lehy T: Hepatocyte growth factor induces colonic cancer cell invasiveness via enhanced motility and protease overproduction. Evidence for PI3 kinase and PKC involvement. Carcinogenesis. 2001, 22: 1035-42. 10.1093/carcin/22.7.1035.
Article
CAS
PubMed
Google Scholar
Liuzzi JP, Cousins RJ: Mammalian zinc transporters. Annu Rev Nutr. 2004, 24: 151-72. 10.1146/annurev.nutr.24.012003.132402.
Article
CAS
PubMed
Google Scholar
Song MK, Heng MC, Rolandelli R, Ament ME, Heng MK: Possible link between zinc intake and colon cancer. J Natl Cancer Inst. 1993, 85: 667-9. 10.1093/jnci/85.8.667.
Article
CAS
PubMed
Google Scholar
Seya T, Tanaka N, Shinji S, Yokoi K, Koizumi M, Teranishi N, Yamashita K, Tajiri T, Ishiwata T, Naito Z: Lumican expression in advanced colorectal cancer with nodal metastasis correlates with poor prognosis. Oncol Rep. 2006, 16: 1225-30.
CAS
PubMed
Google Scholar
Beattie J, Allan GJ, Lochrie JD, Flint DJ: Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis. Biochem J. 2006, 395: 1-19. 10.1042/BJ20060086.
Article
CAS
PubMed
PubMed Central
Google Scholar
Reichling T, Goss KH, Carson DJ, Holdcraft RW, Ley-Ebert C, Witte D, Aronow BJ, Groden J: Transcriptional profiles of intestinal tumours in Apc(Min) mice are unique from those of embryonic intestine and identify novel gene targets dysregulated in human colorectal tumours. Cancer Res. 2005, 65: 166-76.
CAS
PubMed
Google Scholar
Hemers E, Duval C, McCaig C, Handley M, Dockray GJ, Varro A: Insulin-like growth factor binding protein-5 is a target of matrix metalloproteinase-7: implications for epithelial-mesenchymal signaling. Cancer Res. 2005, 65: 7363-9. 10.1158/0008-5472.CAN-05-0157.
Article
CAS
PubMed
Google Scholar
Rho SB, Dong SM, Kang S, Seo SS, Yoo CW, Lee DO, Woo JS, Park SY: Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumour suppressor by inhibiting angiogenesis. Carcinogenesis. 2008, 29: 2106-11. 10.1093/carcin/bgn206.
Article
CAS
PubMed
Google Scholar
Takahashi M, Mutoh M, Kawamori T, Sugimura T, Wakabayashi K: Altered expression of beta-catenin, inducible nitric oxide synthase and cyclooxygenase-2 in azoxymethane-induced rat colon carcinogenesis. Carcinogenesis. 2000, 21: 1319-27. 10.1093/carcin/21.7.1319.
Article
CAS
PubMed
Google Scholar
Ohta T, Takahashi M, Ochiai A: Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers. Cancer Lett. 2005, 239: 246-53. 10.1016/j.canlet.2005.08.014.
Article
PubMed
Google Scholar
Femia AP, Dolara P, Luceri C, Salvadori M, Caderni G: Mucin-depleted foci show strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and are promoted by the inflammatory agent sodium dextran sulfate. Int J Cancer. 2009, 125: 541-7. 10.1002/ijc.24417.
Article
CAS
PubMed
Google Scholar
Gebhardt C, Németh J, Angel P, Hess J: S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol. 2006, 72: 1622-31. 10.1016/j.bcp.2006.05.017.
Article
CAS
PubMed
Google Scholar
Stulík J, Osterreicher J, Koupilová K, Knízek , Macela A, Bures J, Jandík P, Langr F, Dedic K, Jungblut PR: The analysis of S100A9 and S100A8 expression in matched sets of macroscopically normal colon mucosa and colorectal carcinoma: the S100A9 and S100A8 positive cells underlie and invade tumour mass. Electrophoresis. 1999, 20: 1047-54. 10.1002/(SICI)1522-2683(19990101)20:4/5<1047::AID-ELPS1047>3.0.CO;2-E.
Article
PubMed
Google Scholar
Myung SJ, Rerko RM, Yan M, Platzer P, Guda K, Dotson A, Lawrence E, Dannenberg AJ, Lovgren AK, Luo G, Pretlow TP, Newman RA, Willis J, Dawson D, Markowitz SD: 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumourigenesis. Proc Natl Acad Sci USA. 2006, 103: 12098-102. 10.1073/pnas.0603235103.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ambs S, Merriam WG, Bennett WP, Felley-Bosco E, Ogunfusika MO, Oser SM, Klein S, Shields PG, Billiar TR, Harris CC: Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumour angiogenesis and colon cancer progression. Cancer Res. 1998, 58: 334-41.
CAS
PubMed
Google Scholar
Barker N, Clevers H: Mining the Wnt pathway for cancer therapeutics. Nat Rev Drug Discov. 2006, 5: 997-1014. 10.1038/nrd2154.
Article
CAS
PubMed
Google Scholar
The Wnt Homepage: Wnt target genes. [http://www.stanford.edu/~rnusse/pathways/targets.html]
Barker N, van Es JH, Kuipers J, Kujala P, Born van den M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H: Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007, 449: 1003-7. 10.1038/nature06196.
Article
CAS
PubMed
Google Scholar
McClanahan T, Koseoglu S, Smith K, Grein J, Gustafson E, Black S, Kirschmeier P, Samatar AA: Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumours. Cancer Biol Ther. 2006, 5: 419-26. 10.4161/cbt.5.4.2521.
Article
CAS
PubMed
Google Scholar
Biswas S, Chytil A, Washington K, Romero-Gallo J, Gorska AE, Wirth PS, Gautam S, Moses HL, Grady WM: Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer. Cancer Res. 2004, 64: 4687-92. 10.1158/0008-5472.CAN-03-3255.
Article
CAS
PubMed
Google Scholar
Muñoz NM, Upton M, Rojas A, Washington MK, Lin L, Chytil A, Sozmen EG, Madison BB, Pozzi A, Moon RT, Moses HL, Grady WM: Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res. 2006, 66: 9837-44. 10.1158/0008-5472.CAN-06-0890.
Article
PubMed
Google Scholar
Biasi F, Mascia C, Poli G: The contribution of animal fat oxidation products to colon carcinogenesis, through modulation of TGF-β1 signaling. Carcinogenesis. 2008, 29: 890-4. 10.1093/carcin/bgn106.
Article
CAS
PubMed
Google Scholar
Massagué J: TGF-β in Cancer. Cell. 2008, 134: 215-30. 10.1016/j.cell.2008.07.001.
Article
PubMed
PubMed Central
Google Scholar
Bachman KE, Park BH: Duel nature of TGF-beta signaling: tumour suppressor vs. tumour promoter. Curr Opin Oncol. 2005, 17: 49-54. 10.1097/01.cco.0000143682.45316.ae.
Article
CAS
PubMed
Google Scholar
Höglund P, Haila S, Socha J, Tomaszewski L, Saarialho-Kere U, Karjalainen-Lindsberg ML, Airola K, Holmberg C, de la Chapelle A, Kere J: Mutations of the Down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea. Nat Genet. 1996, 14: 316-9. 10.1038/ng1196-316.
Article
PubMed
Google Scholar
Schweinfest CW, Henderson KW, Suster S, Kondoh N, Papas TS: Identification of a colon mucosa gene that is down-regulated in colon adenomas and adenocarcinomas. Proc Natl Acad Sci USA. 1993, 90: 4166-70. 10.1073/pnas.90.9.4166.
Article
CAS
PubMed
PubMed Central
Google Scholar
Meer-Van Kraaij Van Der C, Van Lieshout EM, Kramer E, Meer Van Der R, Keijer J: Mucosal pentraxin (Mptx), a novel rat gene 10-fold down-regulated in colon by dietary heme. FASEB J. 2003, 17: 1277-85. 10.1096/fj.02-1036com.
Article
Google Scholar
Munitz A, Seidu L, Cole ET, Ahrens R, Hogan SP, Rothenberg ME: Resistin-like molecule alpha decreases glucose tolerance during intestinal inflammation. J Immunol. 2009, 182: 2357-63. 10.4049/jimmunol.0803130.
Article
CAS
PubMed
PubMed Central
Google Scholar
Femia AP, Tarquini E, Salvadori M, Ferri S, Giannini A, Dolara P, Caderni G: K-ras mutations and mucin profile in preneoplastic lesions and colon tumours induced in rats by 1,2-dimethylhydrazine. Int J Cancer. 2008, 122: 117-23. 10.1002/ijc.23065.
Article
CAS
PubMed
Google Scholar
Mizoshita T, Tsukamoto T, Inada KI, Hirano N, Tajika M, Nakamura T, Ban H, Tatematsu M: Loss of MUC2 expression correlates with progression along the adenoma-carcinoma sequence pathway as well as de novo carcinogenesis in the colon. Histol Histopathol. 2007, 22: 251-60.
CAS
PubMed
Google Scholar
Ortega AD, Sánchez-Aragó M, Giner-Sánchez D, Sánchez-Cenizo L, Willers I, Cuezva JM: Glucose avidity of carcinomas. Cancer Lett. 2009, 276: 125-35. 10.1016/j.canlet.2008.08.007.
Article
CAS
PubMed
Google Scholar
Halberg RB, Waggoner J, Rasmussen K, White A, Clipson L, Prunuske AJ, Bacher JW, Sullivan R, Washington MK, Pitot HC, Petrini JH, Albertson DG, Dove WF: Long-lived Min mice develop advanced intestinal cancers through a genetically conservative pathway. Cancer Res. 2009, 69: 5768-75. 10.1158/0008-5472.CAN-09-0446.
Article
CAS
PubMed
PubMed Central
Google Scholar
Powell SM, Zilz N, Beazer-Barclay Y, Bryan TM, Hamilton SR, Thibodeau SN, Vogelstein B, Kinzler KW: APC mutations occur early during colorectal tumorigenesis. Nature. 1992, 359: 235-7. 10.1038/359235a0.
Article
CAS
PubMed
Google Scholar
Shibata H, Takano H, Ito M, Shioya H, Hirota M, Matsumoto H, Kakudo Y, Ishioka C, Akiyama T, Kanegae Y, Saito I, Noda T: Alpha-catenin is essential in intestinal adenoma formation. Proc Natl Acad Sci USA. 2007, 104: 18199-204. 10.1073/pnas.0705730104.
Article
CAS
PubMed
PubMed Central
Google Scholar
Vermeulen SJ, Bruyneel EA, Bracke ME, De Bruyne GK, Vennekens KM, Vleminckx KL, Berx GJ, van Roy FM, Mareel MM: Transition from the noninvasive to the invasive phenotype and loss of alpha-catenin in human colon cancer cells. Cancer Res. 1995, 55: 4722-8.
CAS
PubMed
Google Scholar
Raftopoulos I, Davaris P, Karatzas G, Karayannacos P, Kouraklis G: Level of alpha-catenin expression in colorectal cancer correlates with invasiveness, metastatic potential, and survival. J Surg Oncol. 1998, 68: 92-9. 10.1002/(SICI)1096-9098(199806)68:2<92::AID-JSO4>3.0.CO;2-F.
Article
CAS
PubMed
Google Scholar