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  1. The long term outcome of advanced sarcoma patients treated with trabectedin outside of clinical trials and the utility of maintenance treatment has not been reported.

    Authors: Jean-Yves Blay, Antoine Italiano, Isabelle Ray-Coquard, Axel Le Cesne, Florence Duffaud, Maria Rios, Olivier Collard, François Bertucci, Emmanuelle Bompas, Nicolas Isambert, Loic Chaigneau, Philippe Cassier, Binh Bui, Gauthier Decanter, Olfa Derbel, Jean-Michel Coindre…
    Citation: BMC Cancer 2013 13:64
    Content type: Research article Published on:

  2. Rho GTPases are involved in cellular functions relevant to cancer. The roles of RhoA and Rac1 have already been established. However, the role of Rac3 in cancer aggressiveness is less well understood.

    Authors: Caroline Gest, Ulrich Joimel, Limin Huang, Linda-Louise Pritchard, Alexandre Petit, Charlène Dulong, Catherine Buquet, Chao-Quan Hu, Pezhman Mirshahi, Marc Laurent, Françoise Fauvel-Lafève, Lionel Cazin, Jean-Pierre Vannier, He Lu, Jeannette Soria, Hong Li…
    Citation: BMC Cancer 2013 13:63
    Content type: Research article Published on:

  3. Metastatic prostate cancer is a leading cause of cancer-related death in men. Cancer stem cells (CSCs) are involved in tumor progression and metastasis, including in prostate cancer. There is an obvious and ur...

    Authors: Xinlan Fan, Xu Chen, Weixi Deng, Guangzheng Zhong, Qingqing Cai and Tianxin Lin
    Citation: BMC Cancer 2013 13:61
    Content type: Research article Published on:

  4. SPARC is a matricellular glycoprotein with growth-inhibitory and antiangiogenic activity in some cell types. The study of this protein in hematopoietic malignancies led to conflicting reports about its role as...

    Authors: Cesarina Giallongo, Piera La Cava, Daniele Tibullo, Ignazio Barbagallo, Nunziatina Parrinello, Alessandra Cupri, Fabio Stagno, Carla Consoli, Annalisa Chiarenza, Giuseppe A Palumbo and Francesco Di Raimondo
    Citation: BMC Cancer 2013 13:60
    Content type: Research article Published on:

  5. It has been previously reported that IL-22, one of the cytokines secreted by Th17 cells, demonstrates both a protective and inflammatory promotion effect in inflammatory bowel disease (IBD) through STAT3 signa...

    Authors: Runqiu Jiang, Haiyang Wang, Lei Deng, Jiajie Hou, Ruihua Shi, Ming Yao, Yun Gao, Aihua Yao, Xuehao Wang, Lianzhen Yu and Beicheng Sun
    Citation: BMC Cancer 2013 13:59
    Content type: Research article Published on:

  6. The risk of developing cutaneous squamous cell carcinoma (SCC) is markedly increased in organ transplant recipients (OTRs) compared to the normal population. Next to sun exposure, the immunosuppressive regimen...

    Authors: Liesbeth Hameetman, Suzan Commandeur, Jan Nico Bouwes Bavinck, Hermina C Wisgerhof, Frank R de Gruijl, Rein Willemze, Leon Mullenders, Cornelis P Tensen and Harry Vrieling
    Citation: BMC Cancer 2013 13:58
    Content type: Research article Published on:

  7. Peritoneal dissemination is the most common type of recurrence in advanced gastric cancer. The main mechanism is thought to be via the exfoliation of free cancer cells (FCCs) from tumor in the gastric serosa. ...

    Authors: Baojun Huang, Zhe Sun, Zhenning Wang, Chong Lu, Chengzhong Xing, Bo Zhao and Huimian Xu
    Citation: BMC Cancer 2013 13:57
    Content type: Research article Published on:

  8. Several GI peptides linked to intestinal barrier function could be involved in the modification of intestinal permeability and the onset of diarrhea during adjuvant chemotherapy. The aim of the study was to ev...

    Authors: Francesco Russo, Michele Linsalata, Caterina Clemente, Benedetta D’Attoma, Antonella Orlando, Giovanna Campanella, Francesco Giotta and Giuseppe Riezzo
    Citation: BMC Cancer 2013 13:56
    Content type: Research article Published on:

  9. Acute lymphoblastic leukemia (ALL) diagnosed within the first month of life is classified as congenital ALL and has a significantly worse outcome than ALL diagnosed in older children. This suggests that congen...

    Authors: Vivian Y Chang, Giuseppe Basso, Kathleen M Sakamoto and Stanley F Nelson
    Citation: BMC Cancer 2013 13:55
    Content type: Research article Published on:

  10. Obesity has been linked to many adverse health consequences, including breast cancer. This study aims to determine adipocytokine and other biological changes in recently diagnosed breast cancer patients before...

    Authors: Majed S Alokail, Nasser Al-Daghri, Amal Abdulkareem, Hossam M Draz, Sobhy M Yakout, Abdullah M Alnaami, Shaun Sabico, Amal M Alenad and George P Chrousos
    Citation: BMC Cancer 2013 13:54
    Content type: Research article Published on:

  12. Elevated Glasgow Prognostic Score (GPS) has been related to poor prognosis in patients with hepatocellular carcinoma (HCC) undergoing surgical resection or receiving sorafenib. The aim of this study was to inv...

    Authors: Akiyoshi Kinoshita, Hiroshi Onoda, Nami Imai, Akira Iwaku, Mutumi Oishi, Ken Tanaka, Nao Fushiya, Kazuhiko Koike, Hirokazu Nishino, Masato Matsushima, Chisato Saeki and Hisao Tajiri
    Citation: BMC Cancer 2013 13:52
    Content type: Research article Published on:

  13. Today, the treatment of choice for high- and low-grade gliomas requires primarily surgical resection to achieve the best survival and quality of life. Nevertheless, many gliomas within highly eloquent cortical...

    Authors: Sandro M Krieg, Lea Schnurbus, Ehab Shiban, Doris Droese, Thomas Obermueller, Niels Buchmann, Jens Gempt, Bernhard Meyer and Florian Ringel
    Citation: BMC Cancer 2013 13:51
    Content type: Research article Published on:

  14. Several classification systems are available to assess pathological response to neoadjuvant chemotherapy in breast cancer, but reliable biomarkers to predict the efficiency of primary systemic therapy (PST) ar...

    Authors: Ivett Teleki, Tibor Krenacs, Marcell A Szasz, Janina Kulka, Barna Wichmann, Cornelia Leo, Barbel Papassotiropoulos, Cosima Riemenschnitter, Holger Moch and Zsuzsanna Varga
    Citation: BMC Cancer 2013 13:50
    Content type: Research article Published on:

  15. More than half of patients with KRAS-wild type advanced colorectal cancer (CRC) fail anti-EGFR monoclonal antibodies. We studied EGFR-axis messenger RNA (mRNA) expression and RAS, RAF, PIK3CA mutations in orde...

    Authors: George Pentheroudakis, Vassiliki Kotoula, Wendy De Roock, George Kouvatseas, Pavlos Papakostas, Thomas Makatsoris, Demetris Papamichael, Ioannis Xanthakis, Joseph Sgouros, Despina Televantou, Georgia Kafiri, Athanassios C Tsamandas, Evangelia Razis, Eleni Galani, Dimitrios Bafaloukos, Ioannis Efstratiou…
    Citation: BMC Cancer 2013 13:49
    Content type: Research article Published on:

  16. Colon cancer stem cells may drive carcinogenesis and account for chemotherapeutic failure. Although many markers for these cells have been proposed, there is no complete agreement regarding them, nor has their...

    Authors: Angelo Pietro Femia, Piero Dolara, Maddalena Salvadori and Giovanna Caderni
    Citation: BMC Cancer 2013 13:48
    Content type: Research article Published on:

  17. Previously, we performed analysis of gene expression in 46 axillary lymph node negative tumors and identified molecular gene signatures that resulted in different clinical outcomes. The aim of this study was t...

    Authors: Emman Shubbar, Khalil Helou, Anikó Kovács, Szilárd Nemes, Shahin Hajizadeh, Charlotta Enerbäck and Zakaria Einbeigi
    Citation: BMC Cancer 2013 13:47
    Content type: Research article Published on:

  18. Acinic cell carcinoma (ACC) is a rare malignant epithelial neoplasm characterized by the presence of malignant tubular acinar exocrine gland structures. Diagnosis is generally made in salivary glands and in th...

    Authors: Carla B Ripamonti, Mara Colombo, Patrizia Mondini, Manoukian Siranoush, Bernard Peissel, Loris Bernard, Paolo Radice and Maria Luisa Carcangiu
    Citation: BMC Cancer 2013 13:46
    Content type: Case report Published on:

  19. We determined the differently expressed protein profiles and their functions in bladder cancer tissues with the aim of identifying possible target proteins and underlying molecular mechanisms for taking part i...

    Authors: Hong Chung, Bokyung Kim, Seung-Hyo Jung, Kyung-Jong Won, Xiaowen Jiang, Chang-Kwon Lee, So Dug Lim, Sang-Kuk Yang, Ki Hak Song and Hong Sup Kim
    Citation: BMC Cancer 2013 13:45
    Content type: Research article Published on:

  20. To understand the carcinogenesis caused by accumulated genetic and epigenetic alterations and seek novel biomarkers for various cancers, studying differentially expressed genes between cancerous and normal tis...

    Authors: Mingsong Wu, Tao Tu, Yunchao Huang and Yi Cao
    Citation: BMC Cancer 2013 13:44
    Content type: Research article Published on:

  21. The aim of this study is to evaluate the associations between vascular endothelial growth factor (VEGF) Single-nucleotide polymorphisms (SNPs) and clinical outcome in advanced gastric cancer patients treated w...

    Authors: Sung Yong Oh, Hyuk-Chan Kwon, Sung Hyun Kim, Suee Lee, Ji Hyun Lee, Jung-Ah Hwang, Seung Hyun Hong, Christian A Graves, Kevin Camphausen, Hyo-Jin Kim and Yeon-Su Lee
    Citation: BMC Cancer 2013 13:43
    Content type: Research article Published on:

  22. Whether PET scan maximum standard uptake value (SUVmax) could differentiate luminal A from luminal B and help predict the survival of metastatic breast cancer (MBC) patients with luminal subtype is still unkno...

    Authors: Jian Zhang, Zhen Jia, Joseph Ragaz, Ying-Jian Zhang, Min Zhou, Yong-Ping Zhang, Gang Li, Bi-Yun Wang, Zhong-Hua Wang and Xi-Chun Hu
    Citation: BMC Cancer 2013 13:42
    Content type: Research article Published on:

  23. Aberrant expression and activation of the IGF-IR have been reported in a variety of human cancers and have been associated with resistance to HER targeted therapy. In this study, we investigated the effect of ...

    Authors: Nikolaos Ioannou, Alan M Seddon, Angus Dalgleish, David Mackintosh and Helmout Modjtahedi
    Citation: BMC Cancer 2013 13:41
    Content type: Research article Published on:

  24. The receptor activator of NF-κB (RANK), its ligand (RANKL) and osteoprotegerin (OPG) have been reported to play a role in the pathophysiological bone turnover and in the pathogenesis of breast cancer. Based on...

    Authors: Jasmin Teresa Ney, Ingolf Juhasz-Boess, Frank Gruenhage, Stefan Graeber, Rainer Maria Bohle, Michael Pfreundschuh, Erich Franz Solomayer and Gunter Assmann
    Citation: BMC Cancer 2013 13:40
    Content type: Research article Published on:

  25. Maintenance therapy with gefitinib notably improves survival in patients with advanced non-small cell lung cancer (NSCLC) and EGFR mutation-positive tumors, but the economic impact of this practice is unclear.

    Authors: Jun Zhu, Te Li, Xiaohui Wang, Ming Ye, Jian Cai, Yuejuan Xu and Bin Wu
    Citation: BMC Cancer 2013 13:39
    Content type: Research article Published on:

  26. Interleukin-12 (IL-12) based radiosensitization is an effective way of tumor treatment. Local cytokine production, without systemic shedding, might provide clinical benefit in radiation treatment of sarcomas. ...

    Authors: Ales Sedlar, Simona Kranjc, Tanja Dolinsek, Maja Cemazar, Andrej Coer and Gregor Sersa
    Citation: BMC Cancer 2013 13:38
    Content type: Research article Published on:

  27. Post-translational modifications (PTMs) of histones and other proteins are perturbed in tumours. For example, reduced levels of acetylated H4K16 and trimethylated H4K20 are associated with high tumour grade an...

    Authors: Hilary M Collins, Magdy K Abdelghany, Marie Messmer, Baigong Yue, Sian E Deeves, Karin B Kindle, Kempegowda Mantelingu, Akhmed Aslam, G Sebastiaan Winkler, Tapas K Kundu and David M Heery
    Citation: BMC Cancer 2013 13:37
    Content type: Research article Published on:

  28. Cancer of unknown primary site (CUP) is considered an aggressive metastatic disease but whether the prognosis differs from metastatic cancers of known primary site is not known. Such data may give insight into...

    Authors: Matias Riihimäki, Hauke Thomsen, Akseli Hemminki, Kristina Sundquist and Kari Hemminki
    Citation: BMC Cancer 2013 13:36
    Content type: Research article Published on:

  29. Changes in cell shape and plasticity in cytoskeletal dynamics are critically involved in cell adhesion, migration, invasion and the overall process of metastasis. Previous work in our laboratory demonstrated t...

    Authors: BreeAnn N Brandhagen, Chelsea R Tieszen, Tara M Ulmer, Maria S Tracy, Alicia A Goyeneche and Carlos M Telleria
    Citation: BMC Cancer 2013 13:35
    Content type: Research article Published on:

  30. Artemin (ARTN) has been implicated in promoting oncogenicity, tumor growth and invasiveness in diverse human malignancies. However, the clinical and prognostic significance of upstream ligand binding component...

    Authors: Zheng-Sheng Wu, Vijay Pandey, Wen-Yong Wu, Shan Ye, Tao Zhu and Peter E Lobie
    Citation: BMC Cancer 2013 13:34
    Content type: Research article Published on:

  31. Local recurrence is a major factor affecting survival after treatment for head and neck squamous cell carcinoma (HNSCC). It is possible that the normal processes involved in wound healing after surgical remova...

    Authors: Lars Ekblad, Gustaf Lindgren, Emma Persson, Elisabeth Kjellén and Johan Wennerberg
    Citation: BMC Cancer 2013 13:33
    Content type: Research article Published on:

  32. A substantial number of breast cancer patients are identified as being at high risk of developing metastatic disease. With increasing number of targeted therapeutics entering clinical trials, chronic administr...

    Authors: Christian Schem, Dirk Bauerschlag, Sascha Bender, Ann-Christin Lorenzen, Daniel Loermann, Sigrid Hamann, Frank Rösel, Holger Kalthoff, Claus C Glüer, Walter Jonat and Sanjay Tiwari
    Citation: BMC Cancer 2013 13:32
    Content type: Research article Published on:

  33. Exercise programmes are beneficial for cancer patients however evidence is limited in patients with multiple myeloma (MM), a cancer that is characterised by osteolytic bone disease, giving rise to high levels ...

    Authors: Lara Groeneveldt, Gill Mein, Rachel Garrod, Andrew P Jewell, Ken Van Someren, Richard Stephens, Shirley P D’Sa and Kwee L Yong
    Citation: BMC Cancer 2013 13:31
    Content type: Research article Published on:

  34. Fertility is an important issue for long-term survivors of malignancies developing during reproductive years. We designed a population-based study to investigate childbirth in female young adult survivors of n...

    Authors: Nancy N Baxter, Rinku Sutradhar, M Elizabeth DelGuidice, Shawn Forbes, Lawrence F Paszat, Andrew S Wilton, David Urbach and Linda Rabeneck
    Citation: BMC Cancer 2013 13:30
    Content type: Research article Published on:

  35. In the present study, we show that the combination of doxorubicin with the cyclin-dependent kinase inhibitor P276-00 was synergistic at suboptimal doses in the non-small cell lung carcinoma (NSCLC) cell lines ...

    Authors: Maggie J Rathos, Harshal Khanwalkar, Kavita Joshi, Sonal M Manohar and Kalpana S Joshi
    Citation: BMC Cancer 2013 13:29
    Content type: Research article Published on:

  36. Studies evaluating the association between alcohol intake and ovarian carcinoma (OC) are inconsistent. Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, l...

    Authors: Linda E Kelemen, Elisa V Bandera, Kathryn L Terry, Mary Anne Rossing, Louise A Brinton, Jennifer A Doherty, Roberta B Ness, Susanne Krüger Kjær, Jenny Chang-Claude, Martin Köbel, Galina Lurie, Pamela J Thompson, Michael E Carney, Kirsten Moysich, Robert Edwards, Clare Bunker…
    Citation: BMC Cancer 2013 13:28
    Content type: Research article Published on:

  37. As dose-escalation in prostate cancer radiotherapy improves cure rates, a major concern is rectal toxicity. We prospectively assessed an innovative approach of hydrogel injection between prostate and rectum to...

    Authors: Franziska Eckert, Saladin Alloussi, Frank Paulsen, Michael Bamberg, Daniel Zips, Patrick Spillner, Cihan Gani, Ulrich Kramer, Daniela Thorwarth, David Schilling and Arndt-Christian Müller
    Citation: BMC Cancer 2013 13:27
    Content type: Research article Published on:

  38. Human papillomavirus (HPV)-related head and neck cancer has been associated with an improved prognosis in patients treated with radiotherapy (RT) +/− chemotherapy (CT); however, RT combined with epidermal grow...

    Authors: Bella Pajares, Jose M Trigo, Maria D Toledo, Martina Álvarez, Carlos González-Hermoso, Antonio Rueda, Jose A Medina, Vanessa de Luque, Jose M Jerez and Emilio Alba
    Citation: BMC Cancer 2013 13:26
    Content type: Research article Published on:

  39. Choriocarcinoma is a gestational trophoblastic tumor which causes high mortality if left untreated. MicroRNAs (miRNAs) are small non protein-coding RNAs which inhibit target gene expression. The role of miRNAs...

    Authors: Ronald TK Pang, Carmen ON Leung, Cheuk-Lun Lee, Kevin KW Lam, Tian-Min Ye, Philip CN Chiu and William SB Yeung
    Citation: BMC Cancer 2013 13:25
    Content type: Research article Published on:

  40. The expression of a specific set of genes controls the different structures of heparan sulfate proteoglycans (HSPGs), which are involved in the growth, invasion and metastatic properties of cancerous cells. Th...

    Authors: Iván Fernández-Vega, Olivia García, Ainara Crespo, Sonia Castañón, Primitiva Menéndez, Aurora Astudillo and Luis M Quirós
    Citation: BMC Cancer 2013 13:24
    Content type: Research article Published on:

  41. There is scant data regarding disease presentation and treatment response among black men living in Africa. In this study we evaluate disease presentation and early clinical outcomes among Ghanaian men with pr...

    Authors: Kosj Yamoah, Kwamena Beecham, Sarah E Hegarty, Terry Hyslop, Timothy Showalter and Joel Yarney
    Citation: BMC Cancer 2013 13:23
    Content type: Research article Published on:

  42. Malignant pleural mesothelioma is an aggressive tumor that has a poor prognosis and is resistant to unimodal approaches. Multimodal treatment has provided encouraging results.

    Authors: Rea Federico, Favaretto Adolfo, Marulli Giuseppe, Spaggiari Lorenzo, DePas Tommaso Martino, Ceribelli Anna, Paccagnella Adriano, Crivellari Gino, Russo Francesca, Ceccarelli Matteo, Kazeem Gbenga, Marchi Paolo and Facciolo Francesco
    Citation: BMC Cancer 2013 13:22
    Content type: Research article Published on:

  43. MiR-221 is over-expressed in human hepatocellular carcinoma (HCC), but its clinical significance and function in HCC remains uncertain. The aim of the study was to investigate the relationship between miR-221 ...

    Authors: Minhua Rong, Gang Chen and Yiwu Dang
    Citation: BMC Cancer 2013 13:21
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:221

  44. Humanized KS-interleukin-2 (huKS-IL2), an immunocytokine with specificity for epithelial cell adhesion molecule (EpCAM), has demonstrated favorable tolerability and immunologic activity as a single agent.

    Authors: Joseph P Connor, Mihaela C Cristea, Nancy L Lewis, Lionel D Lewis, Philip B Komarnitsky, Maria R Mattiacci, Mildred Felder, Sarah Stewart, Josephine Harter, Jean Henslee-Downey, Daniel Kramer, Roland Neugebauer and Roger Stupp
    Citation: BMC Cancer 2013 13:20
    Content type: Research article Published on:

  45. MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few ...

    Authors: Ting-Yan Shi, Xiao-Jun Chen, Mei-Ling Zhu, Meng-Yun Wang, Jing He, Ke-Da Yu, Zhi-Ming Shao, Meng-Hong Sun, Xiao-Yan Zhou, Xi Cheng, Xiaohua Wu and Qingyi Wei
    Citation: BMC Cancer 2013 13:19
    Content type: Research article Published on:

  46. Despite the increase in cancer incidence in the last years in Serbia, no nation-wide, population-based cancer epidemiology data have been reported. In this study cancer incidence and mortality rates for Serbia...

    Authors: Jovan Mihajlović, Petros Pechlivanoglou, Marica Miladinov-Mikov, Snežana Živković and Maarten J Postma
    Citation: BMC Cancer 2013 13:18
    Content type: Research article Published on:

  47. Conventional therapeutic agents are largely unsatisfactory into the treatment of malignant melanoma. Recently, an innovative approach based on inhibitors of the mutated BRAF gene (which represents the most pre...

    Authors: Giusy Gentilcore, Gabriele Madonna, Nicola Mozzillo, Antoni Ribas, Antonio Cossu, Giuseppe Palmieri and Paolo A Ascierto
    Citation: BMC Cancer 2013 13:17
    Content type: Correspondence Published on:

  48. Interleukin (IL)-11, a cytokine produced by breast cancer, has been implicated in breast cancer-induced osteolysis (bone destruction) but the mechanism(s) of action remain controversial. Some studies show that...

    Authors: Erin M McCoy, Huixian Hong, Hawley C Pruitt and Xu Feng
    Citation: BMC Cancer 2013 13:16
    Content type: Research article Published on:

  49. One of the molecules regulated by the transcription factor, hypoxia inducible factor (HIF), is the hypoxia-responsive hematopoietic factor, erythropoietin (EPO). This may have relevance to the development of r...

    Authors: Christudas Morais, David W Johnson, David A Vesey and Glenda C Gobe
    Citation: BMC Cancer 2013 13:14
    Content type: Review Published on:

  50. The aim of this study was to determine the proportions and predictors of first-degree relatives (FDRs) of colorectal cancer (CRC) patients (i) ever receiving any CRC testing and (ii) receiving CRC screening in...

    Authors: Ryan J Courtney, Christine L Paul, Mariko L Carey, Robert W Sanson-Fisher, Finlay A Macrae, Catherine D’Este, David Hill, Daniel Barker and Jody Simmons
    Citation: BMC Cancer 2013 13:13
    Content type: Research article Published on:

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