Casali PG, Blay JY, ESMO/CONTICANET/EUROBONET Consensus Panel of Experts: Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2010, 21 (Suppl 5): v98-v102.
Article
PubMed
Google Scholar
Van Glabbeke M, van Oosterom AT, Oosterhuis JW, et al: Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: an analysis of 2,185 patients treated with anthracycline-containing first-line regimens-a European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol. 1999, 17: 150-157.
CAS
PubMed
Google Scholar
Judson I, Radford JA, Harris M, et al: Randomised phase II trial of pegylated liposomal doxorubicin (DOXIL/CAELYX) versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma: a study by the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer. 2001, 37: 870-877. 10.1016/S0959-8049(01)00050-8.
Article
CAS
PubMed
Google Scholar
Cassier PA, Dufresne A, Fayette J, Alberti L, Ranchere D, Ray-Coquard I, Blay JY: Emerging drugs for the treatment of soft tissue sarcomas. Expert Opin Emerg Drugs. 2007, 12 (1): 139-153. 10.1517/14728214.12.1.139.
Article
CAS
PubMed
Google Scholar
Van Glabbeke M, Verweij J, Judson I, Nielsen OS: Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas. Eur J Cancer. 2002, 38 (4): 543-549. 10.1016/S0959-8049(01)00398-7.
Article
CAS
PubMed
Google Scholar
Pommier Y, Kohlhagen G, Bailly C, Waring M, Mazumder A, Kohn KW: DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Biochemistry. 1996, 35: 13303-13309. 10.1021/bi960306b.
Article
CAS
PubMed
Google Scholar
Moore BM, Ii FCS, Wheelhouse RT, Hurley LH: Mechanism for the Catalytic Activation of eteinascidin 743 and Its Subsequent Alkylation of Guanine N2. Interact. 1985, 52: 375-
Google Scholar
Zewail-Foote M, Hurley LH: Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J Med Chem. 1999, 42: 2493-2497. 10.1021/jm990241l.
Article
CAS
PubMed
Google Scholar
Minuzzo M, Marchini S, Broggini M, Faircloth G, D’Incalci M, Mantovani R: Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743. Proc Natl Acad Sci USA. 2000, 97: 6780-6784. 10.1073/pnas.97.12.6780.
Article
CAS
PubMed
PubMed Central
Google Scholar
Takebayashi Y, Pourquier P, Zimonjic DB, et al: Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Nat Med. 2001, 7: 961-966. 10.1038/91008.
Article
CAS
PubMed
Google Scholar
Damia G, Silvestri S, Carrassa L, et al: Unique pattern of ET-743 activity in different cellular systems with defined deficiencies in DNA-repair pathways. Int J Cancer. 2001, 92: 583-588. 10.1002/ijc.1221.
Article
CAS
PubMed
Google Scholar
Martinez EJ, Corey EJ, Owa T: Antitumor activity- and gene expression-based profiling of ecteinascidin Et 743 and phthalascidin Pt 650. Chem Biol. 2001, 8: 1151-1160. 10.1016/S1074-5521(01)00082-5.
Article
CAS
PubMed
Google Scholar
Li WW, Takahashi N, Jhanwar S, et al: Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent. Clin Cancer Res. 2001, 7: 2908-2911.
CAS
PubMed
Google Scholar
Takahashi N, Li WW, Banerjee D, Scotto KW, Bertino JR: Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells. Clin Cancer Res. 2001, 7: 3251-3257.
CAS
PubMed
Google Scholar
Izbicka E, Lawrence R, Raymond E, et al: In vitro antitumor activity of the novel marine agent, ecteinascidin-743 (ET-743, NSC-648766) against human tumors explanted from patients. Ann Oncol. 1998, 9: 981-987. 10.1023/A:1008224322396.
Article
CAS
PubMed
Google Scholar
Taamma A, Misset JL, Riofrio M, et al: Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-h continuous infusion in patients with solid tumors. J Clin Oncol. 2001, 19: 1256-1265.
CAS
PubMed
Google Scholar
Villalona-Calero MA, Eckhardt SG, Weiss G, et al: A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies. Clin Cancer Res. 2002, 8: 75-85.
CAS
PubMed
Google Scholar
Ryan DP, Supko JG, Eder JP, et al: Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-h continuous intravenous infusion in patients with solid malignancies. Clin Cancer Res. 2001, 7: 231-242.
CAS
PubMed
Google Scholar
Delaloge S, Yovine A, Taamma A, et al: Ecteinascidin-743: a marine-derived compound in advanced, pretreated sarcoma patients–preliminary evidence of activity. J Clin Oncol. 2001, 19: 1248-1255.
CAS
PubMed
Google Scholar
Zelek L, Yovine A, Brain E, et al: A phase II study of Yondelis (trabectedin, ET-743) as a 24-h continuous intravenous infusion in pretreated advanced breast cancer. Br J Cancer. 2006, 94: 1610-1614. 10.1038/sj.bjc.6603142.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yovine A, Riofrio M, Blay J, et al: Phase II study of Ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients. J Clin Oncol. 2004, 22: 890-900. 10.1200/JCO.2004.05.210.
Article
CAS
PubMed
Google Scholar
Laverdiere C, Kolb EA, Supko JG, et al: Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma. Cancer. 2003, 98: 832-840. 10.1002/cncr.11563.
Article
CAS
PubMed
Google Scholar
Le Cesne A, Blay JY, Judson I, et al: Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial. J Clin Oncol. 2005, 23: 576-584.
Article
CAS
PubMed
Google Scholar
Garcia-Carbonero R, Supko J, Manola J, et al: Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy. J Clin Oncol. 2004, 22: 1480-1490. 10.1200/JCO.2004.02.098.
Article
CAS
PubMed
Google Scholar
Garcia-Carbonero R, Supko JG, Maki RG, et al: Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tissue sarcomas: multicentre phase II and pharmacokinetic study. J Clin Oncol. 2005, 23: 5484-5492. 10.1200/JCO.2005.05.028.
Article
CAS
PubMed
Google Scholar
Blay JY, von Mehren M, Samuels BL, et al: Phase I combination study of trabectedin and doxorubicin in patients with soft-tissue sarcoma. Clin Cancer Res. 2008, 14 (20): 6656-6662. 10.1158/1078-0432.CCR-08-0336.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sessa C, De Braud F, Perotti A, et al: Trabectedin for women with ovarian carcinoma after treatment with platinum and taxanes fails. J Clin Oncol. 2005, 23: 1867-1874. 10.1200/JCO.2005.09.032.
Article
CAS
PubMed
Google Scholar
Demetri GD, et al: Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma and leiomyosarcoma after failure of prior antharcyclines or ifosfamide: results of a randomized phase II study of two different schedules. J Clin Oncol. 2009, 27: 4188-4196. 10.1200/JCO.2008.21.0088.
Article
CAS
PubMed
Google Scholar