de Klein A, van Kessel AG, Grosveld G, Bartram CR, Hagemeijer A, Bootsma D, Spurr NK, Heisterkamp N, Groffen J, Stephenson JR: A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982, 300 (5894): 765-767. 10.1038/300765a0.
Article
CAS
PubMed
Google Scholar
O’Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, Cornelissen JJ, Fischer T, Hochhaus A, Hughes T, et al: Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003, 348 (11): 994-1004. 10.1056/NEJMoa022457.
Article
PubMed
Google Scholar
Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M: Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001, 344 (14): 1038-1042. 10.1056/NEJM200104053441402.
Article
CAS
PubMed
Google Scholar
Talpaz M, Silver RT, Druker BJ, Goldman JM, Gambacorti-Passerini C, Guilhot F, Schiffer CA, Fischer T, Deininger MW, Lennard AL, et al: Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood. 2002, 99 (6): 1928-1937. 10.1182/blood.V99.6.1928.
Article
CAS
PubMed
Google Scholar
Podhajcer OL, Benedetti LG, Girotti MR, Prada F, Salvatierra E, Llera AS: The role of the matricellular protein SPARC in the dynamic interaction between the tumor and the host. Cancer Metastasis Rev. 2008, 27 (4): 691-705. 10.1007/s10555-008-9146-7.
Article
CAS
PubMed
Google Scholar
Funk SE, Sage EH: The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells. Proc Natl Acad Sci USA. 1991, 88 (7): 2648-2652. 10.1073/pnas.88.7.2648.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brekken RA, Sage EH: SPARC, a matricellular protein: at the crossroads of cell-matrix. Matrix Biol. 2000, 19 (7): 569-580. 10.1016/S0945-053X(00)00105-0.
Article
CAS
PubMed
Google Scholar
Motamed K, Sage EH: SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathway. J Cell Biochem. 1998, 70 (4): 543-552. 10.1002/(SICI)1097-4644(19980915)70:4<543::AID-JCB10>3.0.CO;2-I.
Article
CAS
PubMed
Google Scholar
Kupprion C, Motamed K, Sage EH: SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells. J Biol Chem. 1998, 273 (45): 29635-29640. 10.1074/jbc.273.45.29635.
Article
CAS
PubMed
Google Scholar
Raines EW, Lane TF, Iruela-Arispe ML, Ross R, Sage EH: The extracellular glycoprotein SPARC interacts with platelet-derived growth factor (PDGF)-AB and -BB and inhibits the binding of PDGF to its receptors. Proc Natl Acad Sci USA. 1992, 89 (4): 1281-1285. 10.1073/pnas.89.4.1281.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chlenski A, Guerrero LJ, Peddinti R, Spitz JA, Leonhardt PT, Yang Q, Tian Y, Salwen HR, Cohn SL: Anti-angiogenic SPARC peptides inhibit progression of neuroblastoma tumors. Mol Cancer. 2010, 9: 138-10.1186/1476-4598-9-138.
Article
PubMed
PubMed Central
Google Scholar
Pellagatti A, Jadersten M, Forsblom AM, Cattan H, Christensson B, Emanuelsson EK, Merup M, Nilsson L, Samuelsson J, Sander B, et al: Lenalidomide inhibits the malignant clone and up-regulates the SPARC gene mapping to the commonly deleted region in 5q- syndrome patients. Proc Natl Acad Sci USA. 2007, 104 (27): 11406-11411. 10.1073/pnas.0610477104.
Article
CAS
PubMed
PubMed Central
Google Scholar
DiMartino JF, Lacayo NJ, Varadi M, Li L, Saraiya C, Ravindranath Y, Yu R, Sikic BI, Raimondi SC, Dahl GV: Low or absent SPARC expression in acute myeloid leukemia with MLL rearrangements is associated with sensitivity to growth inhibition by exogenous SPARC protein. Leukemia. 2006, 20 (3): 426-432. 10.1038/sj.leu.2404102.
Article
CAS
PubMed
Google Scholar
Hedvat CV, Comenzo RL, Teruya-Feldstein J, Olshen AB, Ely SA, Osman K, Zhang Y, Kalakonda N, Nimer SD: Insights into extramedullary tumour cell growth revealed by expression profiling of human plasmacytomas and multiple myeloma. Br J Haematol. 2003, 122 (5): 728-744. 10.1046/j.1365-2141.2003.04481.x.
Article
CAS
PubMed
Google Scholar
Fenouille N, Puissant A, Dufies M, Robert G, Jacquel A, Ohanna M, Deckert M, Pasquet JM, Mahon FX, Cassuto JP, et al: Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC. Cancer Res. 2010, 70 (23): 9659-9670. 10.1158/0008-5472.CAN-10-2034.
Article
CAS
PubMed
Google Scholar
Li K, Cai R, Dai BB, Zhang XQ, Wang HJ, Ge SF, Xu WR, Lu J: SATB1 regulates SPARC expression in K562 cell line through binding to a specific sequence in the third intron. Biochem Biophys Res Commun. 2007, 356 (1): 6-12. 10.1016/j.bbrc.2007.01.201.
Article
CAS
PubMed
Google Scholar
Yiu GK, Chan WY, Ng SW, Chan PS, Cheung KK, Berkowitz RS, Mok SC: SPARC (secreted protein acidic and rich in cysteine) induces apoptosis in ovarian cancer cells. Am J Pathol. 2001, 159 (2): 609-622. 10.1016/S0002-9440(10)61732-4.
Article
CAS
PubMed
PubMed Central
Google Scholar
Mazzacurati L, Pattacini L, Brusa G, Mancini M, Benvenuti M, Barbieri E, Martinelli G, Baccarani M, Greenberger JS, Santucci MA: Chk2 drives late G1/early S phase arrest of clonal myeloid progenitors expressing the p210 BCR-ABL tyrosine kinase in response to STI571. Hematol J. 2004, 5 (2): 168-177. 10.1038/sj.thj.6200365.
Article
CAS
PubMed
Google Scholar
Andreu EJ, Lledo E, Poch E, Ivorra C, Albero MP, Martinez-Climent JA, Montiel-Duarte C, Rifon J, Perez-Calvo J, Arbona C, et al: BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells. Cancer Res. 2005, 65 (8): 3264-3272.
CAS
PubMed
Google Scholar
Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML, Martin GR: Osteonectin, a bone-specific protein linking mineral to collagen. Cell. 1981, 26 (1 Pt 1): 99-105.
Article
CAS
PubMed
Google Scholar
Tibullo D, Giallongo C, La Cava P, Berretta S, Stagno F, Chiarenza A, Conticello C, Palumbo GA, Di Raimondo F: Effects of imatinib mesylate in osteoblastogenesis. Exp Hematol. 2009, 37 (4): 461-468. 10.1016/j.exphem.2008.12.008.
Article
CAS
PubMed
Google Scholar
Berman E, Nicolaides M, Maki RG, Fleisher M, Chanel S, Scheu K, Wilson BA, Heller G, Sauter NP: Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med. 2006, 354 (19): 2006-2013. 10.1056/NEJMoa051140.
Article
CAS
PubMed
Google Scholar
Fitter S, Dewar AL, Kostakis P, To LB, Hughes TP, Roberts MM, Lynch K, Vernon-Roberts B, Zannettino AC: Long-term imatinib therapy promotes bone formation in CML patients. Blood. 2008, 111 (5): 2538-2547. 10.1182/blood-2007-07-104281.
Article
CAS
PubMed
Google Scholar
Jonsson S, Olsson B, Ohlsson C, Lorentzon M, Mellstrom D, Wadenvik H: Increased cortical bone mineralization in imatinib treated patients with chronic myelogenous leukemia. Haematologica. 2008, 93 (7): 1101-1103. 10.3324/haematol.12373.
Article
PubMed
Google Scholar
Grey A, O’Sullivan S, Reid IR, Browett P: Imatinib mesylate, increased bone formation, and secondary hyperparathyroidism. N Engl J Med. 2006, 355 (23): 2494-2495. 10.1056/NEJMc062388.
Article
CAS
PubMed
Google Scholar
Tibullo D, Barbagallo I, Giallongo C, La Cava P, Branca A, Conticello C, Stagno F, Chiarenza A, Palumbo GA, Di Raimondo F: Effects of second-generation tyrosine kinase inhibitors towards osteogenic differentiation of human mesenchymal cells of healthy donors. Hematol Oncol. 2012, 30 (1): 27-33. 10.1002/hon.988. Epub 2011 May 5
Article
CAS
PubMed
Google Scholar
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA: JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis. Leukemia. 2004, 18 (2): 189-218. 10.1038/sj.leu.2403241.
Article
CAS
PubMed
Google Scholar
Sattler M, Mohi MG, Pride YB, Quinnan LR, Malouf NA, Podar K, Gesbert F, Iwasaki H, Li S, Van Etten RA, et al: Critical role for Gab2 in transformation by BCR/ABL. Cancer Cell. 2002, 1 (5): 479-492. 10.1016/S1535-6108(02)00074-0.
Article
CAS
PubMed
Google Scholar
Lin TS, Mahajan S, Frank DA: STAT signaling in the pathogenesis and treatment of leukemias. Oncogene. 2000, 19 (21): 2496-2504. 10.1038/sj.onc.1203486.
Article
CAS
PubMed
Google Scholar
Neshat MS, Raitano AB, Wang HG, Reed JC, Sawyers CL: The survival function of the Bcr-Abl oncogene is mediated by Bad-dependent and -independent pathways: roles for phosphatidylinositol 3-kinase and Raf. Mol Cell Biol. 2000, 20 (4): 1179-1186. 10.1128/MCB.20.4.1179-1186.2000.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sugimoto Y, Nakamura S, Okinaka K, Hirano I, Ono T, Shigeno K, Shinjo K, Ohnishi K: HOXA10 expression induced by Abl kinase inhibitors enhanced apoptosis through PI3K pathway in CML cells. Leuk Res. 2008, 32 (6): 962-971. 10.1016/j.leukres.2007.11.034.
Article
CAS
PubMed
Google Scholar
Daley GQ: Towards combination target-directed chemotherapy for chronic myeloid leukemia: role of farnesyl transferase inhibitors. Semin Hematol. 2003, 40 (2 Suppl 2): 11-14.
Article
CAS
PubMed
Google Scholar
Tai IT, Dai M, Owen DA, Chen LB: Genome-wide expression analysis of therapy-resistant tumors reveals SPARC as a novel target for cancer therapy. J Clin Invest. 2005, 115 (6): 1492-1502. 10.1172/JCI23002.
Article
CAS
PubMed
PubMed Central
Google Scholar
Holtz M, Forman SJ, Bhatia R: Growth factor stimulation reduces residual quiescent chronic myelogenous leukemia progenitors remaining after imatinib treatment. Cancer Res. 2007, 67 (3): 1113-1120. 10.1158/0008-5472.CAN-06-2014.
Article
CAS
PubMed
Google Scholar
Framson PE, Sage EH: SPARC and tumor growth: where the seed meets the soil?. J Cell Biochem. 2004, 92 (4): 679-690. 10.1002/jcb.20091.
Article
CAS
PubMed
Google Scholar
Jadersten M, Hellstrom-Lindberg E: New clues to the molecular pathogenesis of myelodysplastic syndromes. Exp Cell Res. 2010, 316 (8): 1390-1396. 10.1016/j.yexcr.2010.02.043.
Article
PubMed
Google Scholar
Copland M, Hamilton A, Elrick LJ, Baird JW, Allan EK, Jordanides N, Barow M, Mountford JC, Holyoake TL: Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction. Blood. 2006, 107 (11): 4532-4539. 10.1182/blood-2005-07-2947.
Article
CAS
PubMed
Google Scholar
Graham SM, Jorgensen HG, Allan E, Pearson C, Alcorn MJ, Richmond L, Holyoake TL: Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Blood. 2002, 99 (1): 319-325. 10.1182/blood.V99.1.319.
Article
CAS
PubMed
Google Scholar
Holtz MS, Forman SJ, Bhatia R: Nonproliferating CML CD34+ progenitors are resistant to apoptosis induced by a wide range of proapoptotic stimuli. Leukemia. 2005, 19 (6): 1034-1041. 10.1038/sj.leu.2403724.
Article
CAS
PubMed
Google Scholar
Chlenski A, Liu S, Crawford SE, Volpert OV, DeVries GH, Evangelista A, Yang Q, Salwen HR, Farrer R, Bray J, et al: SPARC is a key Schwannian-derived inhibitor controlling neuroblastoma tumor angiogenesis. Cancer Res. 2002, 62 (24): 7357-7363.
CAS
PubMed
Google Scholar
Palumbo GA, Romeo MA, Di Raimondo F, Giustolisi R: Interferon enhanced minimal residual disease detection in acute promyelocytic leukaemia. Br J Haematol. 1997, 96 (4): 876-877.
CAS
PubMed
Google Scholar
Foresti R, Clark JE, Green CJ, Motterlini R: Thiol compounds interact with nitric oxide in regulating heme oxygenase-1 induction in endothelial cells. Involvement of superoxide and peroxynitrite anions. J Biol Chem. 1997, 272 (29): 18411-18417. 10.1074/jbc.272.29.18411.
Article
CAS
PubMed
Google Scholar