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  1. Gliomas are the most common brain tumours with the high-grade glioblastoma representing the most aggressive and lethal form. Currently, there is a lack of specific glioma biomarkers that would aid tumour subty...

    Authors: Agathe Quesnel, Nathan Coles, Claudio Angione, Priyanka Dey, Tuomo M. Polvikoski, Tiago F. Outeiro, Meez Islam, Ahmad A. Khundakar and Panagiota S. Filippou
    Citation: BMC Cancer 2023 23:174
  2. Novel antibody‒drug conjugates (ADC) have shown great efficacy in HER2-low advanced breast cancer. However, the clinical features of HER2-low disease still need to be clarified. The current study aims to evalu...

    Authors: Qin Shi, Jing Yu, Deyue Liu, Fang Ren, Jiayi Wu and Kunwei Shen
    Citation: BMC Cancer 2023 23:173
  3. Dishevelled paralogs (DVL1, 2, 3) are key mediators of Wnt pathway playing a role in constitutive oncogenic signaling influencing the tumor microenvironment. While previous studies showed correlation of β-cate...

    Authors: Fahmida Rasha, Geetha Priya Boligala, Mingxiao V. Yang, Dalia Martinez-Marin, Isabel Castro-Piedras, Kathryn Furr, Annie Snitman, Sonia Y. Khan, Luis Brandi, Maribel Castro, Hafiz Khan, Nusrat Jahan, Sharilyn Almodovar, Michael W. Melkus, Kevin Pruitt and Rakhshanda Layeequr Rahman
    Citation: BMC Cancer 2023 23:172
  4. Breast cancer is one of the most prevalent malignant diseases in women. The development of dose dense chemotherapy regimens has improved clinical outcomes but has been associated with increased hematological t...

    Authors: Ahmed Rashed, Orla M Fitzpatrick, David J Easty, Zac Coyne, Dearbhaile Collins, Victoria Mallet, Maciej Milewski, Keith Egan, Oscar S Breathnach, Liam Grogan, Bryan T Hennessy and Patrick G Morris
    Citation: BMC Cancer 2023 23:171
  5. Several clear cell renal cell carcinoma (ccRCC) cases harbour fibroblast growth factor receptor 4 (FGFR4) gene copy number (CN) gains. In this study, we investigated the functional contribution of FGFR4 CN amplif...

    Authors: Takafumi Narisawa, Sei Naito, Hiromi Ito, Osamu Ichiyanagi, Toshihiko Sakurai, Tomoyuki Kato and Norihiko Tsuchiya
    Citation: BMC Cancer 2023 23:170
  6. Nasopharyngeal carcinoma (NPC), especially the nonkeratinizing type, is a malignant tumor primarily occurring in southern China and Southeast Asia. Chemotherapy (CT) and combined radiotherapy (RT) is used to t...

    Authors: Feng Ling, Shengen Xu, Xiaochen Li, Xingwang Sun and Wenbo Long
    Citation: BMC Cancer 2023 23:169

    The Correction to this article has been published in BMC Cancer 2023 23:190

  7. DNA methylation is an essential factor in the progression of cervical intraepithelial neoplasia (CIN) to cervical cancer. The aim was to investigate the diagnostic value provided by methylation biomarkers of s...

    Authors: Liye Shi, Xue Yang, Ling He, Chunying Zheng, Zhen Ren, Juweria Abdisamad Warsame, Suye Suye, Lei Yan, Haiyi Cai, Xiao Xiao and Chun Fu
    Citation: BMC Cancer 2023 23:168
  8. A Wilms’ tumor 1 (WT1) oral vaccine, Bifidobacterium longum (B. longum) 420, in which the bacterium is used as a vector for WT1 protein, triggers immune responses through cellular immunity consisting of cytotoxic...

    Authors: Hikaru Minagawa, Yoshiko Hashii, Hiroko Nakajima, Fumihiro Fujiki, Soyoko Morimoto, Jun Nakata, Toshiro Shirakawa, Takane Katayama, Akihiro Tsuboi and Keiichi Ozono
    Citation: BMC Cancer 2023 23:167
  9. Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of melanoma and other cancers. However, no reliable biomarker of survival or response has entered the clinic to identify those patients wit...

    Authors: Alessia Visconti, Niccolò Rossi, Helena Deriš, Karla A Lee, Maja Hanić, Irena Trbojević-Akmačić, Andrew M. Thomas, Laura A. Bolte, Johannes R. Björk, Jahlisa S. Hooiveld-Noeken, Ruth Board, Mark Harland, Julia Newton-Bishop, Mark Harries, Joseph J. Sacco, Paul Lorigan…
    Citation: BMC Cancer 2023 23:166
  10. To identify the main risk factors for metachronous metastatic nasopharyngeal carcinoma (NPC) in different periods after radiotherapy and estimate the weight of various factors in the early or late metachronous...

    Authors: Zhaodong Fei, Huiling Hong, Ting Xu, Yiying Xu, Jiawei Chen, Xiufang Qiu, Jianming Ding, Ye Feng, Chaoxiong Huang, Li Li, Mengying Li and Chuanben Chen
    Citation: BMC Cancer 2023 23:165
  11. High-throughput screening (HTS) of small molecule drug libraries has greatly facilitated the discovery of new cancer drugs. However, most phenotypic screening platforms used in the field of oncology are based ...

    Authors: Tove Selvin, Malin Berglund, Lena Lenhammar, Malin Jarvius, Peter Nygren, Mårten Fryknäs, Rolf Larsson and Claes R Andersson
    Citation: BMC Cancer 2023 23:164
  12. Colposcopic examination with biopsy is the standard procedure for referrals with abnormal cervical cancer screening results; however, the decision to biopsy is controvertible. Having a predictive model may help t...

    Authors: Peng Xue, Samuel Seery, Sumeng Wang, Yu Jiang and Youlin Qiao
    Citation: BMC Cancer 2023 23:163
  13. Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development. However, the role of miRNAs in OSCC d...

    Authors: Guoqiang Xu, Yiyan Yang, Junting Yang, Lanfei Xiao, Xiaotang Wang, Litao Qin, Jiping Gao, Ruijing Xuan, Xiaofen Wu, Zhaoyang Chen, Rui Sun and Guohua Song
    Citation: BMC Cancer 2023 23:162
  14. The classification of thymomas is based on the morphology of epithelial tumor cells and the proportion of lymphocytes. Type A thymomas are composed of the spindle or oval tumor epithelial cells. Tumor cells of...

    Authors: Huiyang Li, Bo Ren, Shili Yu, Hongwen Gao and Ping-Li Sun
    Citation: BMC Cancer 2023 23:161
  15. Clear cell renal cell carcinoma (ccRCC) is common in urinary system tumors. Cuproptosis is a non-apoptotic cell death pathway. Copper binds to fatty acylated mitochondrial proteins and activates various forms ...

    Authors: Junlin Shen, Linhui Wang and Jianbin Bi
    Citation: BMC Cancer 2023 23:160
  16. Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietar...

    Authors: S. G. Yammine, I. Huybrechts, C. Biessy, L. Dossus, S. Panico, M. J. Sánchez, V. Benetou, R. Turzanski-Fortner, V. Katzke, A. Idahl, G. Skeie, K. Standahl Olsen, A. Tjønneland, J. Halkjaer, S. Colorado-Yohar, A. K. Heath…
    Citation: BMC Cancer 2023 23:159
  17. Chronic inflammation is a hallmark of cancer, and it can be stimulated by many factors. Substance P (SP), through binding to neurokinin 1 receptor (NK1R), and pyruvate kinase M2 (PKM2) play critical roles in c...

    Authors: Maha S. Al-Keilani, Roba Bdeir, Rana I. Elstaty and Mohammad A. Alqudah
    Citation: BMC Cancer 2023 23:158
  18. A recent theory supports that high-grade serous epithelial ovarian cancer derives from the fimbrial end of the fallopian tube and during the last decade, a few studies have examined the fallopian tube cytology...

    Authors: Sofia Lekka, Victoria Psomiadou, Theodoros Panoskaltsis, Eleni Tsouma, Natasa Novkovic, Helen Trihia, Olympia Tzaida, Dimitrios Korfias, Panagiotis Giannakas, Christos Iavazzo, Panagiotis Vakas, Nikolaos Vlahos and George Vorgias
    Citation: BMC Cancer 2023 23:157
  19. Diet, alcohol, cigarette smoking, physical inactivity, and body mass index have been studied as risk factors for renal cell cancer (RCC). The joint effects of these lifestyle factors, captured as Healthy Lifes...

    Authors: Romain Meer, Jeroen van de Pol, Piet A. van den Brandt and Leo J. Schouten
    Citation: BMC Cancer 2023 23:156
  20. Galectin-3 (Gal-3), the only chimeric β-galactosides-binding lectin, consists of Gal-3N (N-terminal regulatory peptide) and Gal-3C (C-terminal carbohydrate-recognition domain). Interestingly, Gal-3C could spe...

    Authors: Xiaoge Gao, Pin Jiang, Xiaohuan Wei, Wei Zhang, Jiwei Zheng, Shishuo Sun, Hong Yao, Xiangye Liu and Qing Zhang
    Citation: BMC Cancer 2023 23:154
  21. Glucose and glutamine are the main energy sources for tumor cells. Whether glycolysis and glutaminolysis play a critical role in driving the molecular subtypes of lung adenocarcinoma (LUAD) is unknown. This st...

    Authors: Jinjin Zhang, Xiaopeng Wang, Congkuan Song and Qi Li
    Citation: BMC Cancer 2023 23:152
  22. This retrospective cohort study examined the impact of tetracyclines (TCs) and proton pump inhibitors (PPIs) alone or in combination on the efficacy of epidermal growth factor receptor tyrosine kinase inhibito...

    Authors: Hui-Hsia Hsieh, Tien-Yuan Wu, Chi-Hua Chen, Yu-Hung Kuo and Mann-Jen Hour
    Citation: BMC Cancer 2023 23:151
  23. As a consequence of effective treatment procedures, the number of long-term survivors of colorectal cancer is ever increasing. Adopting the method of a previous study on breast cancer patients, the goal of the...

    Authors: Vinzenz Völkel, Brunhilde Steinger, Michael Koller, Monika Klinkhammer-Schalke and Patricia Lindberg-Scharf
    Citation: BMC Cancer 2023 23:149
  24. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a heterogeneous group of tumors with a broad range of local and systemic treatment options. Still a lack of data regarding treatment sequences exists...

    Authors: Rahel Stiefel, Kuno Lehmann, Thomas Winder and Alexander R. Siebenhüner
    Citation: BMC Cancer 2023 23:148
  25. The protein kinase C (PKC) family of serine/threonine kinases contains more than ten isozymes that are involved in multiple signaling pathways, including cell cycle regulation and carcinogenesis. The PKCε isoz...

    Authors: Areeba Rehman, Maria Shabbir, Yasmin Badshah, Khushbukhat Khan, Janeen H. Trembley, Naeem Mahmood Ashraf, Tayyaba Afsar, Ali Almajwal, Nawaf W. Alruwaili, Ali Alshamari, Tariq Nahar Alanezi and Suhail Razak
    Citation: BMC Cancer 2023 23:147
  26. TAP1 is an immunomodulation-related protein that plays different roles in various malignancies. This study investigated the transcriptional expression profile of TAP1 in uveal melanoma (UVM), revealed its pote...

    Authors: Ru Zhu, Yu-Ting Chen, Bo-Wen Wang, Ya-Yan You, Xing-Hua Wang, Hua-Tao Xie, Fa-Gang Jiang and Ming-Chang Zhang
    Citation: BMC Cancer 2023 23:146
  27. Overall survival (OS) is the gold standard to assess novel therapeutics to treat cancer. However, to identify early efficacy and speed up drug approval, trials have used progression-free survival (PFS) as a su...

    Authors: Zewei Zhang, Chunxia Xie, Tiantian Gao, Yuxian Yang, Yong Yang and Lei Zhao
    Citation: BMC Cancer 2023 23:145
  28. Programmed death-1 (PD-1) and its ligand (PD-L1) inhibitors have been reported in several clinical trials for gastric cancer and gastroesophageal junction cancer (GC/GEJC). We presently carried out a meta anal...

    Authors: Gengwei Huo, Wenjie Liu and Peng Chen
    Citation: BMC Cancer 2023 23:143
  29. Extranodal extension (ENE) is an adverse prognostic factor for oral squamous cell carcinoma (OSCC), and patients with OSCC along with ENE require neck dissection. In this study, we developed a novel ENE histol...

    Authors: Yuri Noda, Mitsuaki Ishida, Ryosuke Yamaka, Yasuhiro Ueno, Tomofumi Sakagami, Takuo Fujisawa, Hiroshi Iwai and Koji Tsuta
    Citation: BMC Cancer 2023 23:142
  30. The epidemiology and treatment of acute promyelocytic leukaemia (APL) are changing. We have incorporated oral arsenic trioxide (oral-ATO) into induction/maintenance.

    Authors: Harinder Gill, Radha Raghupathy, Carmen Y.Y. Lee, Yammy Yung, Hiu-Tung Chu, Michael Y. Ni, Xiao Xiao, Francis P. Flores, Rita Yim, Paul Lee, Lynn Chin, Vivian W.K. Li, Lester Au, Wing-Yan Au, Edmond S.K. Ma, Diwakar Mohan…
    Citation: BMC Cancer 2023 23:141
  31. Cancer patients with financial toxicity experience psychological distress and often miss medical appointments and quit treatments early, which could be a barrier to the effective management of oral chemotherap...

    Authors: Yongfeng Chen, Zhenxiang Chen, Haiyun Jin, Yanrong Chen, Jinbing Bai and Guifen Fu
    Citation: BMC Cancer 2023 23:140
  32. The immunotherapy efficacy on pancreatic cancer remains unsatisfactory. Therefore, it is still necessary to further clarify the pancreatic immune cell infiltration and search for immune-related prognostic indi...

    Authors: Pan-ling Xu, Chien-shan Cheng, Ting Wang, Shu Dong and Ping Li
    Citation: BMC Cancer 2023 23:139
  33. Rearranged during transfection (RET) tyrosine kinase signaling has been previously implicated in endocrine resistant breast cancer, however the mechanism by which this signaling cascade promotes resistance is ...

    Authors: Brooke A. Marks, Ilissa M. Pipia, Chinatsu Mukai, Sachi Horibata, Edward J. Rice, Charles G. Danko and Scott A. Coonrod
    Citation: BMC Cancer 2023 23:138
  34. Diverticular disease has been inconsistently associated with colorectal cancer risk. We conducted a bidirectional Mendelian randomization study to assess this association.

    Authors: Yanxi Zhang, Han Zhang, Jinghan Zhu, Yazhou He, Peng Wang, Doudou Li, Xiaozhuan Liu, Wen Jin, Junxi Zhang, Chuan Xu, Zengli Yu, Xin Zhao and Lingling Cui
    Citation: BMC Cancer 2023 23:137
  35. There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which ...

    Authors: Cengiz Karacin, Berna Oksuzoglu, Ayşe Demirci, Merve Keskinkılıç, Naziyet Köse Baytemür, Funda Yılmaz, Oğuzhan Selvi, Dilek Erdem, Esin Avşar, Nail Paksoy, Necla Demir, Sema Sezgin Göksu, Sema Türker, Ertuğrul Bayram, Abdüssamet Çelebi, Hatice Yılmaz…
    Citation: BMC Cancer 2023 23:136

    The Correction to this article has been published in BMC Cancer 2023 23:192

  36. Stonin1 (STON1) is an endocytic protein but its role in cancer remains unclear. Here, we investigated the immune role of STON1 in kidney renal clear cell carcinoma (KIRC).

    Authors: Axiu Zheng, Jianrong Bai, Yanping Ha, Yaping Yu, Yonghao Fan, Meihua Liang, Yanda Lu, Zhihua Shen, Botao Luo and Wei Jie
    Citation: BMC Cancer 2023 23:135
  37. Breast tumors show heterogeneity containing cancer stem cells as a small subpopulation of a tumor mass. CD44 as a cancer stem cells antigen is abnormally expressed by carcinomas of epithelial origin. Also, ove...

    Authors: Elaheh Gheybi, Ahmad Asoodeh and Jafar Amani
    Citation: BMC Cancer 2023 23:134
  38. Transporter associated with antigen processing 1 (TAP1) is a molecule involved in processing and presentation of major histocompatibility complex class I restricted antigens, including tumor-associated antigen...

    Authors: Zewei Tu, Kuangxun Li, Qiankun Ji, Yuyang Huang, Shigang Lv, Jingying Li, Lei Wu, Kai Huang and Xingen Zhu
    Citation: BMC Cancer 2023 23:133
  39. The ProtonCare Study Group (PCSG) was formed with the purpose to develop and implement a framework for evaluation of proton beam therapy (PBT) and the related care at a novel clinic (Skandionkliniken), based o...

    Authors: K Sjövall, U Langegård, P Fransson, E Nevo-Ohlsson, I Kristensen, K Ahlberg and B Johansson
    Citation: BMC Cancer 2023 23:132
  40. To explore the correlation of tumor necrosis factor-α-induced protein 8-like protein 3 (TIPE3) expressions in colorectal cancer (CRC) with tumor-immune infiltration and patient prognosis.

    Authors: Yue Xu, Yong Zhu, Hengbo Xia, Yanan Wang, Lin Li, Hong Wan, Shuping Zhang, Aman Xu, Liecheng Wang, Jiao Gong and Pingping Zhang
    Citation: BMC Cancer 2023 23:131
  41. Radiotherapy is an important treatment for lung cancer, mainly by triggering DNA double-strand breaks to induce cell death. Blocking DNA damage repair can increase the radiosensitivity of tumor cells. Recent s...

    Authors: Zhipeng Du, Fangxiao Zhang, Lei Liu, Hui Shen, Tingting Liu, Jing Jin, Nanxi Yu, Zhijie Wan, Hang Wang, Xuguang Hu, Yuanyuan Chen and Jianming Cai
    Citation: BMC Cancer 2023 23:130
  42. The tumor microenvironment (TME) in breast cancer plays a vital role in occurrence, development, and therapeutic responses. However, immune and stroma constituents in the TME are major obstacles to understandi...

    Authors: Xiao Chen, Jianzhong Zhang, Xinhan Lei, Lei Yang, Wanwan Li, Lu Zheng, Shuai Zhang, Yihan Ding, Jianing Shi, Lei Zhang, Jia Li, Tong Tang and WenJun Jia
    Citation: BMC Cancer 2023 23:129
  43. Few highly accurate tests can diagnose central lymph node metastasis (CLNM) of papillary thyroid cancer (PTC). Genetic sequencing of tumor tissue has allowed the targeting of certain genetic variants for perso...

    Authors: Zhongzhi Wang, Limeng Qu, Qitong Chen, Yong Zhou, Hongtao Duan, Baifeng Li, Yao Weng, Juan Su and Wenjun Yi
    Citation: BMC Cancer 2023 23:128
  44. The prognostic significance of the relapse interval in patients with resected oral cavity squamous cell carcinoma (OCSCC) is a matter of ongoing debate. In this large-scale, registry-based, nationwide study, w...

    Authors: Chi-Ying Tsai, Yu-Wen Wen, Shu-Ru Lee, Shu-Hang Ng, Chung-Jan Kang, Li-Yu Lee, Chuen Hsueh, Chien-Yu Lin, Kang-Hsing Fan, Hung-Ming Wang, Chia-Hsun Hsieh, Chih-Hua Yeh, Chih-Hung Lin, Chung-Kan Tsao, Tuan-Jen Fang, Shiang-Fu Huang…
    Citation: BMC Cancer 2023 23:126
  45. B cell maturation antigen (BCMA) targeted immunotherapies have demonstrated remarkable clinical efficacy in multiple myeloma (MM). Here, we evaluated the BCMA expression in MM and other plasma cell dyscrasias ...

    Authors: Yanjie Xu, Xia Mao, Yimei Que, Menglei Xu, Chunhui Li, Varlene Daniela Fernandes Almeida, Di Wang and Chunrui Li
    Citation: BMC Cancer 2023 23:123

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