Multiple myeloma (MM) patients with t(14;20) have a poor prognosis and their outcome has not improved following the introduction of bortezomib (Bzb). The mechanism underlying the resistance to proteasome inhib...
Authors: Ya-Wei Qiang, Shiqiao Ye, Yuhua Huang, Yu Chen, Frits Van Rhee, Joshua Epstein, Brian A. Walker, Gareth J. Morgan and Faith E. Davies
Infiltration into lymphatic vessels is a critical step in breast cancer metastasis. Lymphatics undergo changes that facilitate metastasis as a result of activation of the cells lining lymphatic vessels, lympha...
Authors: Alexandra R. Harris, Matthew J. Perez and Jennifer M. Munson
Trans-arterial radio-embolization (TARE) is an emerging treatment for the management of hepatocellular carcinoma (HCC). TARE may compete with systemic chemotherapy, sorafenib, in intermediate stage patients wi...
Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O
Authors: Jeon Hwang-Bo, Mun Gyeong Bae, Jong-Hwa Park and In Sik Chung
Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the a...
Authors: Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, Jeong Su Oh and Jae-Sung Kim
Usually misdiagnosed, Inflammatory Breast Cancer (IBC) is the most aggressive form of non-metastatic breast cancer. This orphan disease is more frequent in North Africa. Despite intensive treatment, the surviv...
Authors: Meriem Slaoui, Abdou Azaque Zoure, Fatima Zahra Mouh, Youssef Bensouda, Mohammed El Mzibri, Youssef Bakri and Mariam Amrani
Cancer is the second leading cause of death in the Caribbean, including the islands of Trinidad and Tobago (TT). The population of TT consists of over 1.3 million people with diverse ancestral and sociocultura...
Authors: Wayne A. Warner, Tammy Y. Lee, Kimberly Badal, Tanisha M. Williams, Smriti Bajracharya, Vasavi Sundaram, Nigel A. Bascombe, Ravi Maharaj, Marjorie Lamont-Greene, Allana Roach, Melissa Bondy, Matthew J. Ellis, Timothy R. Rebbeck, Simeon Slovacek, Jingqin Luo, Adetunji T. Toriola…
YAP, a potent oncogene and major downstream effector of the mammalian Hippo tumor suppressor pathway can act as either oncogene or tumor suppressor gene based on the type of tissue involved. Despite various st...
Authors: Sumayya Abdul Sattar Real, Farah Parveen, Asad Ur Rehman, Mohammad Aasif Khan, Sankaravamasam Venkata Suryanarayan Deo, Nootan Kumar Shukla and Syed Akhtar Husain
The treatment of acute lymphoblastic leukemia (ALL) and osteosarcoma (OSC) is very effective: the vast majority of patients recover and survive for decades. However, they still need to face serious adverse eff...
Authors: Judit C. Sági, Bálint Egyed, Andrea Kelemen, Nóra Kutszegi, Márta Hegyi, András Gézsi, Martina Ayaka Herlitschke, Andrea Rzepiel, Lili E. Fodor, Gábor Ottóffy, Gábor T. Kovács, Dániel J. Erdélyi, Csaba Szalai and Ágnes F. Semsei
HER2 over-expression is related with a poor prognosis in patients with invasive breast cancer tumors. Clinical associations have reported that somatic mutations of p53 more frequently detected in cases of spor...
Authors: A. A. Román-Rosales, E. García-Villa, L. A. Herrera, P. Gariglio and J. Díaz-Chávez
A major challenge for those living with cancers of the upper gastrointestinal tract (oesophagus, stomach and pancreas), is the impact of the disease and treatment on nutritional status and quality of life. People...
Authors: Lauren Hanna, Catherine E. Huggins, Kate Furness, Mary Anne Silvers, June Savva, Helena Frawley, Daniel Croagh, Paul Cashin, Liang Low, Judith Bauer, Helen Truby and Terrence Haines
The Union for International Cancer Control (UICC) tumor-node-metastasis (TNM) classification is a key gastric cancer prognosis system. This study aimed to create a new TNM system to provide a reference for the...
Authors: Zhiqiong Wang, Mo Li, Zhen Xu, Yanlin Jiang, Huizi Gu, Ying Yu, Haitao Zhu, Hao Zhang, Ping Lu, Junchang Xin, Hong Xu and Caigang Liu
The purpose of this case report is to describe a conjunctiva and eyelid Kaposi’s sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infect...
Authors: Filipe Sousa Neves, Joana Braga, João Cardoso da Costa, Joaquim Sequeira and Sandra Prazeres
The role of forkhead-box A1 (FOXA1) and Androgen receptor (AR) in breast cancer (BC) has been extensively studied. However, the prognostic role of their co-expression in Estrogen receptor positive (ER+) BC has...
Authors: Nelson Rangel, Nicoletta Fortunati, Simona Osella-Abate, Laura Annaratone, Claudio Isella, Maria Graziella Catalano, Letizia Rinella, Jasna Metovic, Renzo Boldorini, Davide Balmativola, Pietro Ferrando, Francesca Marano, Paola Cassoni, Anna Sapino and Isabella Castellano
Anti-PD-1 and BRAF-inhibitors (BRAFi) have been approved as first-line treatments in advanced melanoma. To date, no prospective data are available to give the best sequence of treatment. The objective of this ...
Authors: M. Amini-Adle, N. Khanafer, M. Le-Bouar, G. Duru, S. Dalle and L. Thomas
Although originally identified as a putative metastasis suppressor, increasing studies have confirmed a possible role for Nm23-H1 in DNA repair, through the base excision repair and nucleotide excision repair ...
Authors: Ya Sheng, Mingfang Xu, Chongyi Li, Yanli Xiong, Yi Yang, Xunjie Kuang, Dong Wang and Xueqin Yang
Heat Shock Proteins (HSPs), a family of genes with key roles in proteostasis, have been extensively associated with cancer behaviour. However, the HSP family is quite large and many of its members have not bee...
Authors: Felipe C. M. Zoppino, Martin E. Guerrero-Gimenez, Gisela N. Castro and Daniel R. Ciocca
The prognostic value of preoperative controlling nutritional status (CONUT) has been reported in many malignancies. In present study, we aimed to clarify the prognostic impact of CONUT in gastric cancer (GC) r...
Authors: Xuechao Liu, Deyao Zhang, Enzi Lin, Yongming Chen, Wei Li, Yingbo Chen, Xiaowei Sun and Zhiwei Zhou
The aim of this study was to compare the efficacies of the XELOX and DOS regimens as preoperative chemotherapy in patients with locally advanced gastric cancer.
Authors: Yan Wang, Xi Cheng, Yue-hong Cui, Jun Hou, Yuan Ji, Yi-hong Sun, Zhen-bin Shen, Feng-lin Liu and Tian-shu Liu
Eribulin mesylate is currently indicated as a sequential monotherapy to be administered after two chemotherapeutic regimens, including anthracycline and taxane treatments, for treatment of metastatic breast ca...
The advent of tyrosine kinase inhibitors (TKIs) has changed the treatment of RAI refractory, unresectable recurrent differentiated thyroid cancer (DTC), which was formerly treated with multidisciplinary remedies.
DNA mutations occur randomly and sporadically in growth-related genes, mostly on cytosines. Demethylation of cytosines may lead to genetic instability through spontaneous deamination. Aims were whole genome me...
Authors: Béla Molnár, Orsolya Galamb, Bálint Péterfia, Barnabás Wichmann, István Csabai, András Bodor, Alexandra Kalmár, Krisztina Andrea Szigeti, Barbara Kinga Barták, Zsófia Brigitta Nagy, Gábor Valcz, Árpád V. Patai, Péter Igaz and Zsolt Tulassay
Esophageal adenocarcinoma (EAC) incidence is increasing rapidly. Esophageal cancer has the second lowest 5-year survival rate of people diagnosed with cancer in Canada. Given the poor survival and the potentia...
Authors: Hla-Hla Thein, Nathaniel Jembere, Kednapa Thavorn, Kelvin K. W. Chan, Peter C. Coyte, Claire de Oliveira, Chin Hur and Craig C. Earle
Invasive cervical cancer (ICC) is caused by high-risk human papillomavirus types (HR-HPVs) and is usually preceded by a long phase of intraepithelial neoplasia (CIN). Before invasion, (epi) genetic changes, po...
Authors: Barbara Pardini, Daniela De Maria, Antonio Francavilla, Cornelia Di Gaetano, Guglielmo Ronco and Alessio Naccarati
Genes associated with hereditary breast and ovarian cancer (HBOC) and colorectal cancer (CRC) predisposition have been shown to play a role in pancreatic cancer susceptibility. Growing evidence suggests that p...
Authors: Erin L. Young, Bryony A. Thompson, Deborah W. Neklason, Matthew A. Firpo, Theresa Werner, Russell Bell, Justin Berger, Alison Fraser, Amanda Gammon, Cathryn Koptiuch, Wendy K. Kohlmann, Leigh Neumayer, David E. Goldgar, Sean J. Mulvihill, Lisa A. Cannon-Albright and Sean V. Tavtigian
Effective treatment options for advanced pancreatic cancer are finite. NAPOLI-1, a phase III randomized trial, demonstrated the efficacy of nanoliposomal irinotecan with fluorouracil/leucovorin (nal-IRI + 5-FU...
Authors: Danielle C. Glassman, Randze L. Palmaira, Christina M. Covington, Avni M. Desai, Geoffrey Y. Ku, Jia Li, James J. Harding, Anna M. Varghese, Eileen M. O’Reilly and Kenneth H. Yu
Cancer cells require increased levels of nutrients such as amino acids to sustain their rapid growth. In particular, leucine and glutamine have been shown to be important for growth and proliferation of some b...
Authors: Michelle van Geldermalsen, Lake-Ee Quek, Nigel Turner, Natasha Freidman, Angel Pang, Yi Fang Guan, James R. Krycer, Renae Ryan, Qian Wang and Jeff Holst
Orphan nuclear receptors ERRα, ERRβ and ERRγ that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology. Their homology with the canonical estrogen ...
Authors: Kanchan Kumari, Amit K. Adhya, Arabinda Kumar Rath, P. B. Reddy and Sandip K. Mishra
The neuronal intermediate filament alpha-internexin (α-internexin) is a cytoskeleton protein which is involved in the tumor initiation and progression. In this study, we examined the expression and prognosis v...
Authors: Yuhong Wang, Yuanjia Chen, Xiaoxing Li, Wanming Hu, Yu Zhang, Luohai Chen, Minhu Chen and Jie Chen
Emerging inflammatory response biomarkers are developed to predict the survival of patients with cancer, the aim of our study is to establish an inflammation-related nomogram based on the classical predictive ...
Authors: Ying Wang, Xiao Qu, Ngar-Woon Kam, Kai Wang, Hongchang Shen, Qi Liu and Jiajun Du
Progesterone receptor (PR) is expressed from a single gene as two isoforms, PRA and PRB. In normal breast human tissue, PRA and PRB are expressed in equimolar ratios, but isoform ratio is altered during malign...
Authors: María José Carlini, María Sol Recouvreux, Marina Simian and Maria Aparecida Nagai
Uterine serous carcinoma (USC) is a rare but aggressive subtype of endometrial carcinoma. Large-scale comprehensive efforts have resulted in an improved molecular understanding of its pathogenesis, and the p53...
Authors: Katharina Bischof, Stian Knappskog, Ingunn Stefansson, Emmet Martin McCormack, Jone Trovik, Henrica Maria Johanna Werner, Kathrine Woie, Bjorn Tore Gjertsen and Line Bjorge
MicroRNAs can be used in the prognosis of malignancies; however, their regulatory mechanisms are unknown, especially in pancreatic ductal adenocarcinoma (PDAC).
Authors: Ce Li, Qian Dong, Xiaofang Che, Ling Xu, Zhi Li, Yibo Fan, Kezuo Hou, Shuo Wang, Jinglei Qu, Lu Xu, Ti Wen, Xianghong Yang, Xiujuan Qu and Yunpeng Liu
Pancreatic cancer is the fourth-leading cause of cancer deaths in the United States. The silent nature of the disease and its poor prognosis, the need for further research, along with the need to assess the ou...
Authors: Anas M. Saad, Tarek Turk, Muneer J. Al-Husseini and Omar Abdel-Rahman
The insurance reimbursement rate of medical cost affects the quality and quantity of health services provided in China. The nature of this relationship, however, has not been reliably described in the field of...
Authors: Xi Li, Qi Zhou, Xinyu Wang, Shaofei Su, Meiqi Zhang, Hao Jiang, Jiaying Wang and Meina Liu
We previously showed that knockdown of nuclear factor E2-related factor 2 (Nrf2) resulted in suppression of hepatitis C virus (HCV) infection. In this study, whether brusatol, an Nrf2 inhibitor, has dual anti-...
Evidence suggests reallocating daily sedentary time to physical activity or sleep confers important health benefits in cancer survivors. Despite emerging research suggesting physical activity as a treatment fo...
Authors: Diane K. Ehlers, Jason Fanning, Elizabeth A. Salerno, Susan Aguiñaga, Josh Cosman, Joan Severson, Arthur F. Kramer and Edward McAuley
Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells. In this work we analyze changes in the patterns of express...
Authors: Ainara Crespo, Olivia García-Suárez, Iván Fernández-Vega, María Pilar Solis-Hernandez, Beatriz García, Sonia Castañón and Luis M. Quirós
Oral cancer is a serious problem owing to its poor prognosis and destruction of patients’ eating ability as well as facial appearance. Epidemiological studies can provide aetiological clues for prevention. The...
Prostate and breast cancer can have a lot of negative consequences such as fatigue, sleep difficulties and emotional distress, which decrease quality of life. Group interventions showed benefits to emotional d...
Authors: C. Grégoire, H. Nicolas, I. Bragard, F. Delevallez, I. Merckaert, D. Razavi, D. Waltregny, M.-E. Faymonville and A. Vanhaudenhuyse
Almost all of the extracellular matrix (ECM) components can be degraded by the endoproteinases matrix metalloproteinases (MMPs). Important regulators of MMPs, and thereby of the extracellular environment, are ...
Authors: Camilla Böckelman, Ines Beilmann-Lehtonen, Tuomas Kaprio, Selja Koskensalo, Taina Tervahartiala, Harri Mustonen, Ulf-Håkan Stenman, Timo Sorsa and Caj Haglund
The hypercoagulable state associated with pancreatic adenocarcinoma (PDA) results in increased risk of venous thromboembolism, leading to substantial morbidity and mortality. Recently, neutrophil extracellular...
Authors: Brian A. Boone, Pranav Murthy, Jennifer Miller-Ocuin, W. Reed Doerfler, Jarrod T. Ellis, Xiaoyan Liang, Mark A. Ross, Callen T. Wallace, Jason L. Sperry, Michael T. Lotze, Matthew D. Neal and Herbert J. Zeh III
Novel non-invasive biomarkers for gastric cancer (GC) are needed, because the present diagnostic methods for GC are either invasive or insensitive and non-specific in clinic. The presence of stable circulating...
Authors: Gaoping Zhao, Tao Jiang, Yanzhuo Liu, Guoli Huai, Chunbin Lan, Guiquan Li, Guiqing Jia, Kang Wang and Maozhu Yang
More than 50% of metastatic melanoma patients have a specific mutation in the serine/threonine kinase BRAF. This results in constitutive activation of the RAS-RAF-MEK-ERK-MAP kinase pathway, which causes uncon...
Authors: Jingjing Xiao, Michael E. Egger, Kelly M. McMasters and Hongying Hao
High-grade salivary gland cancer is a distinct clinical entity that has aggressive disease progression and early systemic spread. However, because of the rarity of the disease, the clinical outcomes, prognosti...
Authors: Jeon Yeob Jang, Nayeon Choi, Young-Hyeh Ko, Man Ki Chung, Young-Ik Son, Chung-Hwan Baek, Kwan-Hyuck Baek and Han-Sin Jeong
To examine the efficacy and safety of induction therapy with paclitaxel and bevacizumab followed by switch maintenance therapy with eribulin (ISMT) in Japanese patients with HER2-negative metastatic breast can...
Authors: Kenichi Inoue, Jun Ninomiya, Tsuyoshi Saito, Kei Kimizuka and Masafumi Kurosumi
KMT2/MLL proteins are commonly overexpressed or mutated in cancer and have been shown to support cancer maintenance. These proteins are responsible for methylating histone 3 at lysine 4 and promoting transcrip...
Authors: Beth K. Neilsen, Binita Chakraborty, Jamie L. McCall, Danielle E. Frodyma, Richard L. Sleightholm, Kurt W. Fisher and Robert E. Lewis
Hypoxia stimulates metastasis in cancer and is linked to poor patient prognosis. In tumours, oxygen levels vary and hypoxic regions exist within a generally well-oxygenated tumour. However, whilst the heteroge...
Authors: Hannah Harrison, Henry J. Pegg, Jamie Thompson, Christian Bates and Paul Shore
Blockade of PD-1 receptor may provide proof of concepts for the activity of an immune-modulation approach for the treatment of breast cancer (BC). Zoledronic acid (ZA) has been proven to inhibit angiogenesis, ...
Authors: Yuan Li, Yang Du, Ting Sun, Huadan Xue, Zhengyu Jin and Jie Tian
Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery. Retrospective clinical st...
Authors: Ru Li, Chunyun Xiao, Hengrui Liu, Yujie Huang, James P. Dilger and Jun Lin
