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  1. N-end rule ubiquitination pathway is known to be disrupted in many diseases, including cancer. UBR5, an E3 ubiquitin ligase, is mutated and/or overexpressed in human lung cancer cells suggesting its pathologic...

    Authors: Kumar Saurabh, Parag P. Shah, Mark A. Doll, Leah J. Siskind and Levi J. Beverly

    Citation: BMC Cancer 2020 20:824

    Content type: Research article

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  2. Differentiation syndrome (DS) is the main life-threatening adverse event that occurs in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA). Cytokine imbalances have been re...

    Authors: Luciana Yamamoto de Almeida, Diego Antonio Pereira-Martins, Ana Sílvia Gouvêa Lima, Márcia Sueli Baggio, Luisa Corrêa de Araujo Koury, Ana Paula Lange, Sarah Cristina Bassi, Priscila Santos Scheucher and Eduardo Magalhães Rego

    Citation: BMC Cancer 2020 20:821

    Content type: Research article

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  3. Cell-free DNA’s (cfDNA) use as a biomarker in cancer is challenging due to genetic heterogeneity of malignancies and rarity of tumor-derived molecules. Here we describe and demonstrate a novel machine-learning...

    Authors: Clinton L. Cario, Emmalyn Chen, Lancelote Leong, Nima C. Emami, Karen Lopez, Imelda Tenggara, Jeffry P. Simko, Terence W. Friedlander, Patricia S. Li, Pamela L. Paris, Peter R. Carroll and John S. Witte

    Citation: BMC Cancer 2020 20:820

    Content type: Research article

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  4. Pesticide exposure is a suspected risk factor for childhood cancer. We investigated the risk of developing childhood cancer in relation to parental occupational exposure to pesticides in Switzerland for the pe...

    Authors: Astrid Coste, Helen D. Bailey, Mutlu Kartal-Kaess, Raffaele Renella, Aurélie Berthet and Ben D. Spycher

    Citation: BMC Cancer 2020 20:819

    Content type: Research article

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  5. Oligodendroglioma (ODG) are CNS resistant tumors characterized by their unique molecular signature, namely a combined deletion of 1p and 19q simultaneously to an IDH1/2 mutation. These tumors have a more favor...

    Authors: Dieter H. Heiland, Robin Ohle, Debora Cipriani, Pamela Franco, Daniel Delev, Simon P. Behriger, Elias Kellner, Gergana Petrova, Nicolas Neidert, Irina Mader, Mateo Fariña Nuñez, Horst Urbach, Roman Sankowski, Jürgen Beck and Oliver Schnell

    Citation: BMC Cancer 2020 20:818

    Content type: Research article

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  6. The empirical dietary index for hyperinsulinemia (EDIH) score is a validated food-based dietary score that assesses the ability of whole-food diets to predict plasma c-peptide concentrations. Although the EDIH...

    Authors: Fred K. Tabung, Anne Noonan, Dong Hoon Lee, Mingyang Song, Steven K. Clinton, Daniel Spakowicz, Kana Wu, En Cheng, Jeffrey A. Meyerhardt, Charles S. Fuchs and Edward L. Giovannucci

    Citation: BMC Cancer 2020 20:817

    Content type: Research article

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  7. Recently, copy number alteration (CNA) of 9p24.1 were demonstrated in 10% of diffuse large b-cell lymphoma (DLBCL), with gene expression and mutation profiles that were similar to those of primary mediastinal ...

    Authors: Xuemin Xue, Wenting Huang, Tian Qiu, Lei Guo, Jianming Ying and Ning Lv

    Citation: BMC Cancer 2020 20:816

    Content type: Research article

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  8. Trophoblast cell surface antigen 2 (TROP2) is overexpressed in many squamous cell carcinomas and promotes tumor development and invasion. The association between TROP2 expression and occurrence and development...

    Authors: Baoping Zhang, Shuting Gao, Ruiping Li, Yiting Li, Rui Cao, Jingyang Cheng, Yumeng Guo, Errui Wang, Ying Huang and Kailiang Zhang

    Citation: BMC Cancer 2020 20:815

    Content type: Research article

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  9. Tumor microenvironment (TME) plays an important role in malignant tumors. Our study aimed to investigate the effect of the TME and related genes in osteosarcoma patients.

    Authors: Chuan Hu, Chuan Liu, Shaoqi Tian, Yuanhe Wang, Rui Shen, Huili Rao, Jianyi Li, Xu Yang, Bo Chen and Lin Ye

    Citation: BMC Cancer 2020 20:814

    Content type: Research article

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  10. By investigating treatment patterns and outcomes in locally advanced head and neck squamous cell carcinoma (LA-HNSCC), we aimed at providing valuable insights into the optimal therapeutic strategy for physicia...

    Authors: Yun-Gyoo Lee, Eun Joo Kang, Bhumsuk Keam, Jin-Hyuk Choi, Jin-Soo Kim, Keon Uk Park, Kyoung Eun Lee, Jung Hye Kwon, Keun-Wook Lee, Min Kyoung Kim, Hee Kyung Ahn, Seong Hoon Shin, Hye Ryun Kim, Sung-Bae Kim and Hwan Jung Yun

    Citation: BMC Cancer 2020 20:813

    Content type: Research article

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  11. Microwave ablation (MWA) is widely used to treat unresectable primary and secondary malignancies of the liver, and a limited number of studies indicate that ablation can cause not only necrosis at the in situ ...

    Authors: Jing Zhao, Qiang Li, Merlin Muktiali, Bingjie Ren, Yingxi Hu, Dapeng Li, Zhi Li, Daoming Li, Yufeng Xie, Min Tao and Rongrui Liang

    Citation: BMC Cancer 2020 20:812

    Content type: Research article

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  12. Pulmonary blastoma (PB) is a rare lung primary malignancy with poorly understood risk factors and prognosis. We sought to investigate the epidemiologic features and long-term outcomes of PB.

    Authors: Xiang Bu, Jing Liu, Linyan Wei, Xiqiang Wang and Mingwei Chen

    Citation: BMC Cancer 2020 20:811

    Content type: Research article

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  13. In 2013, Jinan KingMed Diagnostics (JKD) first established a systematic cervical cytology training and quality control (QC) program in Shandong Province, China. We compared the efficacy of high-risk human papi...

    Authors: Dongman Zhao, Liran Zhang, Fengxiang Xie, Dezhi Peng, Jie Wei, Lingbo Jiang, Shoudu Zhang and Debo Qi

    Citation: BMC Cancer 2020 20:810

    Content type: Research article

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  14. The aim of this study was to investigate the optimal order of radiation therapy in patients affected by stage IIIA pathologic N2 (IIIA/N2) non-small-cell lung cancer (NSCLC) and to identify its potential risk ...

    Authors: Hongxia Duan, Long Liang, Shuanshuan Xie and Changhui Wang

    Citation: BMC Cancer 2020 20:809

    Content type: Research article

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  15. This study aimed to determine the efficacy and complications of intravitreal chemotherapy-assisted endoresection for refractory International Classification of Retinoblastoma (ICRB) group D retinoblastoma in m...

    Authors: Xiling Yu, Xueke Li, Yue Xing, Siduo Lu, Silvia Tanumiharjo and Jin Ma

    Citation: BMC Cancer 2020 20:808

    Content type: Research article

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  16. In recent years, lung cancer (LC) incidence has increased in Iran. The use of opium and its derivatives (O&D) has increased as well. This study aimed to investigate the association between the use of O&D and L...

    Authors: Ahmad Naghibzadeh-Tahami, Maryam Marzban, Vahid Yazdi-Feyzabadi, Shahryar Dabiri, Shokrollah Mohseni, Reza Abbasi Rayeni, Mitra Samareh Fekri, Mohammad Hasan Larizadeh, Behnaz Karimpour and Narges Khanjani

    Citation: BMC Cancer 2020 20:807

    Content type: Research article

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  17. Non-small cell lung cancer is the most common cause of cancer death worldwide, highlighting the need for novel therapeutic concepts. In particular, there is still a lack of treatment strategies for the group o...

    Authors: Farastuk Bozorgmehr, Inn Chung, Petros Christopoulos, Johannes Krisam, Marc A. Schneider, Lena Brückner, Daniel Wilhelm Mueller, Michael Thomas and Stefan Rieken

    Citation: BMC Cancer 2020 20:806

    Content type: Study protocol

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  18. Patients who have undergone radical cystectomy for urinary bladder cancer are not sufficiently physically active and therefore may suffer complications leading to readmissions. A physical rehabilitation progra...

    Authors: Andrea Porserud, Patrik Karlsson, Elisabeth Rydwik, Markus Aly, Lars Henningsohn, Malin Nygren-Bonnier and Maria Hagströmer

    Citation: BMC Cancer 2020 20:805

    Content type: Study protocol

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  19. Many antipsychotics elevate prolactin, a hormone implicated in breast cancer aetiology however no studies have investigated antipsychotic use in patients with breast cancer. This study investigated if antipsyc...

    Authors: Blánaid M. Hicks, John Busby, Ken Mills, Francis A. O’Neil, Stuart A. McIntosh, Shu-Dong Zhang, Fabio Giuseppe Liberante and Chris R. Cardwell

    Citation: BMC Cancer 2020 20:804

    Content type: Research article

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  20. Recently, the endothelial Activation and Stress Index (EASIX) score has been reported to predict overall survival (OS) after allogeneic stem cell transplantation. This study evaluated the prognostic role of EA...

    Authors: Ga-Young Song, Sung-Hoon Jung, Kihyun Kim, Seok Jin Kim, Sang Eun Yoon, Ho Sup Lee, Mihee Kim, Seo-Yeon Ahn, Jae-Sook Ahn, Deok-Hwan Yang, Hyeoung-Joon Kim and Je-Jung Lee

    Citation: BMC Cancer 2020 20:803

    Content type: Research article

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  21. Clinical trials have been conducted to clarify the beneficial effects of VD3 (1α,25-dihydroxy vitamin D3, also known as calcitriol) treatment in prostate cancer. However, the molecular mechanisms underlying th...

    Authors: Ko Igarashi, Yoshihiro Yui, Kenta Watanabe, Jun Kumai, Yasuko Nishizawa, Chisato Miyaura, Masaki Inada and Satoru Sasagawa

    Citation: BMC Cancer 2020 20:802

    Content type: Research article

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  22. The main treatment methods for early gastric cancer (EGC) include endoscopic submucosal dissection (ESD) and radical gastrectomy. However, appropriate treatment for patients who exceed the absolute indications...

    Authors: Zhi Zheng, Jie Yin, Ziyu Li, Yingjiang Ye, Bo Wei, Xin Wang, Yantao Tian, Mengyi Li, Qian Zhang, Na Zeng, Rui Xu, Guangyong Chen, Jie Zhang, Peng Li, Jun Cai, Hongwei Yao…

    Citation: BMC Cancer 2020 20:801

    Content type: Study protocol

    Published on:

  23. To improve the postoperative prognosis of patients with lung cancer, predicting the recurrence high-risk patients is needed for the efficient application of adjuvant chemotherapy. However, predicting lung canc...

    Authors: Yusuke Takanashi, Kazuhito Funai, Shumpei Sato, Akikazu Kawase, Hong Tao, Yutaka Takahashi, Haruhiko Sugimura, Mitsutoshi Setou, Tomoaki Kahyo and Norihiko Shiiya

    Citation: BMC Cancer 2020 20:800

    Content type: Research article

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  24. The diagnostic performance of intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) in the differential diagnosis of pulmonary tumors remained debatable among published studies. This study aimed t...

    Authors: Jianye Liang, Jing Li, Zhipeng Li, Tiebao Meng, Jieting Chen, Weimei Ma, Shen Chen, Xie Li, Yaopan Wu and Ni He

    Citation: BMC Cancer 2020 20:799

    Content type: Research article

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  25. The optimal chemotherapy regimen for treating HIV associated NHL in low resource settings is unknown. We conducted a retrospective study to describe survival rates, treatment response rates and adverse events ...

    Authors: Clement D. Okello, Abrahams Omoding, Henry Ddungu, Yusuf Mulumba and Jackson Orem

    Citation: BMC Cancer 2020 20:798

    Content type: Research article

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  26. Several works suggest the importance of autophagy during esophageal carcinoma development. The aim of the study is to construct a scoring system according to the expression profiles of major autophagy-related ...

    Authors: Chongxiang Chen, Siliang Chen, Huijiao Cao, Jiaojiao Wang, Tianmeng Wen, Xiaochun Hu and Huan Li

    Citation: BMC Cancer 2020 20:797

    Content type: Research article

    Published on:

  27. Head and neck squamous cell carcinoma (HNSCC) is the sixth most common tumor in human. Research has shown that HPV status HNSCC is a unique prognosis factor, which may due to its immune infiltration landscape....

    Authors: Hao Zeng, Xindi Song, Jianrui Ji, Linyan Chen, Qimeng Liao and Xuelei Ma

    Citation: BMC Cancer 2020 20:796

    Content type: Research article

    Published on:

  28. In the scope of the European Commission Initiative on Breast Cancer (ECIBC) the Monitoring and Evaluation (M&E) subgroup was tasked to identify breast cancer screening programme (BCSP) performance indicators, ...

    Authors: Sergei Muratov, Carlos Canelo-Aybar, Jean-Eric Tarride, Pablo Alonso-Coello, Nadya Dimitrova, Bettina Borisch, Xavier Castells, Stephen W. Duffy, Patricia Fitzpatrick, Markus Follmann, Livia Giordano, Solveig Hofvind, Annette Lebeau, Cecily Quinn, Alberto Torresin, Claudia Vialli…

    Citation: BMC Cancer 2020 20:795

    Content type: Research article

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  29. Orthodenticle homeobox 1 (OTX1) is a transcription factor that plays an important role in various human cancers. However, the function of OTX1 in laryngeal squamous cell carcinoma (LSCC) is largely unknown. We...

    Authors: Xiu-Ping Tu, Hao Li, Liang-Si Chen, Xiao-Ning Luo, Zhong-Ming Lu, Si-Yi Zhang and Shao-Hua Chen

    Citation: BMC Cancer 2020 20:794

    Content type: Research article

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  30. The five-year cumulative incidence rate in patients diagnosed with stage I small-cell lung cancer (SCLC) who were instructed to undergo surgery was from 40 to 60%.The death competition influence the accuracy o...

    Authors: Jianjie Li, Qiwen Zheng, Xinghui Zhao, Jun Zhao, Tongtong An, Meina Wu, Yuyan Wang, Minglei Zhuo, Jia Zhong, Xue Yang, Bo Jia, Hanxiao Chen, Zhi Dong, Jingjing Wang, Yujia Chi, Xiaoyu Zhai…

    Citation: BMC Cancer 2020 20:793

    Content type: Research article

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  31. The role of post-mastectomy radiotherapy (PMRT) in the treatment of patients with T1–2N1 breast cancer is controversial. This study’s purpose was to evaluate the risk of recurrence of T1–2N1 breast cancer and ...

    Authors: Shulian Wang, Ge Wen, Yu Tang, Yong Yang, Hao Jing, Jianyang Wang, Jianghu Zhang, Xuran Zhao, Guangyi Sun, Jing Jin, Yongwen Song, Yueping Liu, Hui Fang, Yujing Zhang and Yexiong Li

    Citation: BMC Cancer 2020 20:792

    Content type: Research article

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  32. Curcumin is herbal compound that has been shown to have anti-cancer effects in pre-clinical and clinical studies. The anti-cancer effects of curcumin include inhibiting the carcinogenesis, inhibiting angiogene...

    Authors: Kamran Mansouri, Shna Rasoulpoor, Alireza Daneshkhah, Soroush Abolfathi, Nader Salari, Masoud Mohammadi, Shabnam Rasoulpoor and Shervin Shabani

    Citation: BMC Cancer 2020 20:791

    Content type: Research article

    Published on:

  33. Accurate detection of patients with minimal residual disease (MRD) after surgery for stage II colon cancer (CC) remains an urgent unmet clinical need to improve selection of patients who might benefit form adj...

    Authors: S. J. Schraa, K. L. van Rooijen, D. E. W. van der Kruijssen, C. Rubio Alarcón, J. Phallen, M. Sausen, J. Simmons, V. M. H. Coupé, W. M. U. van Grevenstein, S. Elias, H. M. Verkooijen, M. M. Laclé, L. J. W. Bosch, D. van den Broek, G. A. Meijer, V. E. Velculescu…

    Citation: BMC Cancer 2020 20:790

    Content type: Study protocol

    Published on:

  34. MEIS1 (Myeloid ecotropic viral integration site 1) as a homeobox (HOX) transcription factor plays regulatory roles in a variety of cellular processes including development, differentiation, survival, apoptosis...

    Authors: Selma Zargari, Shabnam Negahban Khameneh, Abolfazl Rad and Mohammad Mahdi Forghanifard

    Citation: BMC Cancer 2020 20:789

    Content type: Research article

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  35. The incidence of thyroid carcinoma is increasing all over the world. Some studies have suggested that the change of adipokines expression can induce thyroid carcinoma. However, other studies have come to the o...

    Authors: Junyu Zhao, Jing Wen, Shengnan Wang, Jinming Yao, Lin Liao and Jianjun Dong

    Citation: BMC Cancer 2020 20:788

    Content type: Research article

    Published on:

  36. Cardiovascular disease (CVD) remains the largest cause of death in breast cancer survivors. The aim of this study was to explore the impact of exercise intensity on aerobic fitness and autonomic cardiac regula...

    Authors: Kellie Toohey, Kate Pumpa, Andrew McKune, Julie Cooke, Marijke Welvaert, Joseph Northey, Clare Quinlan and Stuart Semple

    Citation: BMC Cancer 2020 20:787

    Content type: Research article

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  37. Meningiomas are the most common primary central nervous system tumors. Potential risk factors include obesity, height, history of allergy/atopy, and autoimmune diseases, but findings are conflicting. This stud...

    Authors: Matan Ben-Zion Berliner, Lior Haim Katz, Estela Derazne, Hagai Levine, Lital Keinan-Boker, Alexandra Benouaich-Amiel, Omer Gal, Andrew A Kanner, Yosef Laviv, Asaf Honig, Tali Siegal, Jacob Mandel, Gilad Twig and Shlomit Yust-Katz

    Citation: BMC Cancer 2020 20:786

    Content type: Research article

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  38. Pneumonitis is a possible side effect of radiotherapy for lung cancer. Since it can occur up to several months following treatment, symptoms may not be associated with previous radiotherapy, and pneumonitis ca...

    Authors: Dirk Rades, Elisa Marie Werner, Esther Glatzel, Marie-Christine Eggert, Denise Olbrich, Soeren Tvilsted and Sabine Bohnet

    Citation: BMC Cancer 2020 20:785

    Content type: Study protocol

    Published on:

  39. Cancer cells cooperate with cells that compose their environment to promote tumor growth and invasion. Among them, adipocytes provide lipids used as a source of energy by cancer cells and adipokines that contr...

    Authors: Martin Paré, Cédric Y. Darini, Xi Yao, Bérengère Chignon-Sicard, Samah Rekima, Simon Lachambre, Virginie Virolle, Adriana Aguilar-Mahecha, Mark Basik, Christian Dani and Annie Ladoux

    Citation: BMC Cancer 2020 20:784

    Content type: Research article

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  40. BCD-022 is a trastuzumab biosimilar which was shown to be equivalent to reference trastuzumab in a wide panel of physicochemical studies as well as preclinical studies in vitro and in vivo. International multi...

    Authors: Sergey M. Alexeev, Andrey V. Khorinko, Guzel Z. Mukhametshina, Konstantin G. Shelepen, Olga N. Burdaeva, Sergey A. Kulik, Chiradoni Thugappa Satheesh, Kirti Srivastava, Mummaneni Vikranth, Fedor Kryukov, Anastasia N. Paltusova, Mariya S. Shustova and Roman A. Ivanov

    Citation: BMC Cancer 2020 20:783

    Content type: Research article

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  41. Adenocarcinoma of the gastroesophageal junction (GEJ) Siewert type II can be resected by transthoracic esophagectomy or transhiatal extended gastrectomy. Both allow for a complete tumor resection, yet there is...

    Authors: Jessica M. Leers, Laura Knepper, Arjen van der Veen, Wolfgang Schröder, Hans Fuchs, Petra Schiller, Martin Hellmich, Ulrike Zettelmeyer, Lodewijk A. A. Brosens, Alexander Quaas, Jelle P. Ruurda, Richard van Hillegersberg and Christiane J. Bruns

    Citation: BMC Cancer 2020 20:781

    Content type: Study protocol

    Published on:

  42. The influence of anastomotic leakage (AL) on local recurrence rates and survival in rectal cancer remains controversial. The aim of this study was to analyze the effect of asymptomatic anastomotic leakage (AAL...

    Authors: Alice Artus, Nicolas Tabchouri, Othman Iskander, Nicolas Michot, Olivier Muller, Urs Giger-Pabst, Pascal Bourlier, Céline Bourbao-Tournois, Aurore Kraemer-Bucur, Thierry Lecomte, Ephrem Salamé and Mehdi Ouaissi

    Citation: BMC Cancer 2020 20:780

    Content type: Research article

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  43. Survivors of germ-cell tumors (GCT) may suffer from long-term adverse consequences. Our study was conducted to assess a long-term sexual functioning in GCT survivors.

    Authors: M. Chovanec, L. Vasilkova, L. Petrikova, J. Obertova, P. Palacka, K. Rejlekova, Z. Sycova-Mila, K. Kalavska, D. Svetlovska, B. Mladosievicova, J. Mardiak and M. Mego

    Citation: BMC Cancer 2020 20:779

    Content type: Research article

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  44. Angiosarcomas (AS) have poor prognosis and often metastasize to distant sites. The potential predictors of metastatic angiosarcomas (MAS) have not been extensively investigated. The main objective of this stud...

    Authors: Shihong Ren, Yucheng Wang, Zhan Wang, Jinxiang Shao and Zhaoming Ye

    Citation: BMC Cancer 2020 20:778

    Content type: Research article

    Published on:

  45. Gastric neoplasms containing neuroendocrine carcinoma (NEC) components are rare malignancies with highly aggressive behavior and a poor prognosis and include pure NEC and mixed tumors containing NEC components...

    Authors: Jiahui Chen, Anqiang Wang, Ke Ji, Zhaode Bu and Jiafu Ji

    Citation: BMC Cancer 2020 20:777

    Content type: Research article

    Published on:

  46. It is estimated that around 15–30% of patients with early stage colon cancer benefit from adjuvant chemotherapy. We are currently not capable of upfront selection of patients who benefit from chemotherapy, whi...

    Authors: I. van den Berg, S. van de Weerd, J. M. L. Roodhart, G. R. Vink, R. R. J. Coebergh van den Braak, C. R. Jimenez, S. G. Elias, D. van Vliet, M. Koelink, E. Hong, W. M. U. van Grevenstein, M. G. H. van Oijen, R. G. H. Beets-Tan, J. H. J. M. van Krieken, J. N. M. IJzermans, J. P. Medema…

    Citation: BMC Cancer 2020 20:776

    Content type: Study protocol

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  47. PARP inhibitors niraparib and talazoparib are FDA approved for special cases of breast cancer. PARP is an interesting repair protein which is frequently affected in cancer cells. We studied the combined action...

    Authors: Verena Weigert, Tina Jost, Markus Hecht, Ilka Knippertz, Lucie Heinzerling, Rainer Fietkau and Luitpold V. Distel

    Citation: BMC Cancer 2020 20:775

    Content type: Research article

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  48. Immunosenescence biomarkers and peripheral blood parameters are evaluated separately as possible predictive markers of immunotherapy. Here, we illustrate the use of a causal inference model to identify predict...

    Authors: Patricia Lorenzo-Luaces, Lizet Sanchez, Danay Saavedra, Tania Crombet, Wim Van der Elst, Ariel Alonso, Geert Molenberghs and Agustin Lage

    Citation: BMC Cancer 2020 20:772

    Content type: Research article

    Published on:

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