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  1. Ovarian cancer (OV) is one of the most common malignant tumors of gynecology oncology. The lack of effective early diagnosis methods and treatment strategies result in a low five-year survival rate. Also, immu...

    Authors: Shibai Yan, Juntao Fang, Yongcai Chen, Yong Xie, Siyou Zhang, Xiaohui Zhu and Feng Fang

    Citation: BMC Cancer 2020 20:1205

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:55

  3. Streptozocin (STZ) is used for treating both pancreatic (PanNET) and gastrointestinal (GI-NET) neuroendocrine tumors but its therapeutic efficacy is relatively low in GI-NETs. Therefore, it has become pivotal ...

    Authors: Hirofumi Watanabe, Yuto Yamazaki, Fumiyoshi Fujishima, Komoto Izumi, Masayuki Imamura, Susumu Hijioka, Kazuhiro Toriyama, Yasushi Yatabe, Atsushi Kudo, Fuyuhiko Motoi, Michiaki Unno and Hironobu Sasano

    Citation: BMC Cancer 2020 20:1195

    Content type: Research article

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  4. Due to the increased risk of viral infection and the severe shortage of medical resources during the pandemic of COVID-19, most hospitals in the epidemic areas significantly reduced non-emergency admissions an...

    Authors: Songxiao Xu, Xiangdong Cheng, Zhiwen Pan, Qian Song, Yihong Wang, Juan Xiong, Yongyi Chen, Fan Fan, Jing Zhu, Wanying Wu, Xueying Deng, Yanpin Yu, Xiaohong Xu, Wenhu Chen, Tao Zhu, Yang Yu…

    Citation: BMC Cancer 2020 20:1194

    Content type: Research article

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  5. Acute myeloid leukemia (AML) is a heterogeneous disease that frequently relapses after standard chemotherapy. Therefore, there is a need for the development of novel chemotherapeutic agents that could treat AM...

    Authors: Sook-Kyoung Heo, Eui-Kyu Noh, Ho-Min Yu, Do Kyoung Kim, Hye Jin Seo, Yoo Jin Lee, Jaekyung Cheon, Su Jin Koh, Young Joo Min, Yunsuk Choi and Jae-Cheol Jo

    Citation: BMC Cancer 2020 20:1193

    Content type: Research article

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  6. Lymphovascular invasion (LVI), which includes vascular or lymphatic invasions, is a representative prognostic factor even in patients with resected stage IA non-small cell lung cancer (NSCLC). Because tegafur-...

    Authors: Tomoshi Tsuchiya, Ryotaro Kamohara, Masashi Muraoka, Takeshi Nagayasu, Sho Saeki, Mitsuhiro Takenoyama, Makoto Suzuki, Kazuo Inada, Shoji Tokunaga, Tomayoshi Hayashi, Shogo Urabe, Takaomi Koga, Shinji Akamine and Kenji Sugio

    Citation: BMC Cancer 2020 20:1192

    Content type: Research article

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  7. Organized breast and cervical cancer screening programme could only provide services at no cost for a fraction of socioeconomic-deprived women in China and other low-resource countries, however, little evidenc...

    Authors: Heling Bao, Limin Wang, Matthew Brown, Mei Zhang, Katherine Hunt, Jiangli Di, Zhenping Zhao, Shu Cong, Jing Fan, Liwen Fang and Linhong Wang

    Citation: BMC Cancer 2020 20:1191

    Content type: Research article

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  8. Cisplatin is the first-line chemotherapeutic drug for non-small cell lung cancer (NSCLC), and emerging evidences suggests that targeting circular RNAs (circRNAs) is an effective strategy to increase cisplatin-...

    Authors: Xiang Zhu, Jing Han, Huiyin Lan, Qingren Lin, Yuezhen Wang and Xiaojiang Sun

    Citation: BMC Cancer 2020 20:1190

    Content type: Research article

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  9. Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. In traditional anti-cancer therapy, epidermal growth factor recep...

    Authors: Hao Gong, Yongwen Li, Yin Yuan, Weiting Li, Hongbing Zhang, Zihe Zhang, Ruifeng Shi, Minghui Liu, Chao Liu, Chen Chen, Hongyu Liu and Jun Chen

    Citation: BMC Cancer 2020 20:1189

    Content type: Research article

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  10. It is often difficult to diagnose inflammatory bowel disease (IBD)-associated neoplasia endoscopically due to background inflammation. In addition, due to the absence of sensitive tumor biomarkers, countermeas...

    Authors: Hideaki Kinugasa, Sakiko Hiraoka, Kazuhiro Nouso, Shumpei Yamamoto, Mami Hirai, Hiroyuki Terasawa, Eriko Yasutomi, Shohei Oka, Masayasu Ohmori, Yasushi Yamasaki, Toshihiro Inokuchi, Masahiro Takahara, Keita Harada, Takehiro Tanaka and Hiroyuki Okada

    Citation: BMC Cancer 2020 20:1188

    Content type: Research article

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  11. MNAT1 (menage a trois 1, MAT1), a cyclin-dependent kinase-activating kinase (CAK) complex, highly expressed in diverse cancers and was involved in cancer molecular pathogenesis. However, its deliverance profil...

    Authors: Chensheng Qiu, Weiliang Su, Nana Shen, Xiaoying Qi, Xiaolin Wu, Kai Wang, Lin Li, Zhu Guo, Hao Tao, Guanrong Wang, Bohua Chen and Hongfei Xiang

    Citation: BMC Cancer 2020 20:1187

    Content type: Research article

    Published on:

  12. Choroidal metastases are the most common eye metastatic site. The prevalence of choroidal metastases in NSCLC patients has been reported to vary from 0.2 to 7% in historical series. Although previously reporte...

    Authors: Clémentine Bouchez, Johan Pluvy, Ghassen Soussi, Marina Nguenang, Solenn Brosseau, Morgan Tourne, Mégane Collin, Nathalie Théou-Anton, Alice Guyard, Jamila Ammar, Antoine Khalil, Gérard Zalcman and Valérie Gounant

    Citation: BMC Cancer 2020 20:1186

    Content type: Research article

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  13. Immune checkpoint inhibitors (ICI) either alone or in combination with chemotherapy have expanded our choice of agents for the palliative treatment of non-small cell lung cancer (NSCLC) patients. Unfortunately...

    Authors: Wolfgang M. Brueckl, Joachim H. Ficker and Gloria Zeitler

    Citation: BMC Cancer 2020 20:1185

    Content type: Review

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  14. Borderline resectable pancreatic cancer (BRPC) is frequently associated with positive surgical margins and a poor prognosis because the tumor is in contact with major vessels. This study evaluated the relation...

    Authors: Sho Yasuta, Tatsushi Kobayashi, Hidetoshi Aizawa, Shinichiro Takahashi, Masafumi Ikeda, Masaru Konishi, Motohiro Kojima, Hirofumi Kuno, Katsuhiko Uesaka, Soichiro Morinaga, Atsushi Miyamoto, Hirochika Toyama, Norihisa Takakura, Keishi Sugimachi and Wataru Takayama

    Citation: BMC Cancer 2020 20:1184

    Content type: Research article

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  16. Tumor micro-angiogenesis and lymphangiogenesis are effective prognostic predictors in many solid malignancies. However, its role on Xp11.2 translocation RCC has not been fully elucidated. Herein, we purposed t...

    Authors: Wenliang Ma, Jun Yang, Ning Liu, Xiaohong Pu, Feng Qu, Linfeng Xu, Xiaozhi Zhao, Xiaogong Li, Gutian Zhang, Hongqian Guo, Dongmei Li and Weidong Gan

    Citation: BMC Cancer 2020 20:1182

    Content type: Research article

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  17. Thyroid malignancies are among the most common endocrine cancers worldwide. Owing to the angiogenic nature of these malignancies, tyrosine kinase inhibitors (TKIs) are an attractive potential treatment. Howeve...

    Authors: Saumil Datar, Maria Cabanillas, Ramona Dadu, David Ost and Horiana B. Grosu

    Citation: BMC Cancer 2020 20:1181

    Content type: Research article

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  18. Anchoring filament protein ladinin-1 (LAD1) was related to the aggressive progression of breast, lung, laryngeal and thyroid cancers. However, the association of LAD1 with colorectal cancer remained unknown. H...

    Authors: Byul Moon, Suk-Jin Yang, Seong Min Park, Sang-Hyun Lee, Kyu Sang Song, Eun-Jeong Jeong, Mijin Park, Jang-Seong Kim, Young Il Yeom and Jung-Ae Kim

    Citation: BMC Cancer 2020 20:1180

    Content type: Research article

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  19. Gastric and colorectal cancers are the most common malignant tumours, leading to a significant number of cancer-related deaths worldwide. Recently, increasing evidence has demonstrated that cancer cells exhibi...

    Authors: Azer Farah, Maria Kabbage, Salsabil Atafi, Amira Jaballah Gabteni, Mouadh Barbirou, Mouna Madhioub, Lamine Hamzaoui, Mousadak Azzouz Mohamed, Hassen Touinsi, Asma Ouakaa Kchaou, Emna Chelbi, Samir Boubaker, Rahma Ben Abderrazek and Balkiss Bouhaouala-Zahar

    Citation: BMC Cancer 2020 20:1179

    Content type: Research article

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  20. Bladder cancer cells orchestrate tumour progression by pro-inflammatory cytokines. Cytokines modulate the local tumour microenvironment and increase the susceptibility of tumour distant tissues for metastasis....

    Authors: A. John, C. Günes, C. Bolenz, S. Vidal-y-Sy, A. T. Bauer, S. W. Schneider and C. Gorzelanny

    Citation: BMC Cancer 2020 20:1178

    Content type: Research article

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  21. Cancer of unknown primary (CUP) is usually treated with nonselective and empirical chemotherapy; however, its prognosis is generally poor, with a median survival of less than a year. Thus, clinicians eagerly a...

    Authors: Yosuke Mitani, Masashi Kanai, Tadayuki Kou, Shigeki Kataoka, Keitaro Doi, Junichi Matsubara, Shinya Ohashi, Shigemi Matsumoto and Manabu Muto

    Citation: BMC Cancer 2020 20:1177

    Content type: Case report

    Published on:

  23. Early diagnosis is important for the timely treatment of gallbladder carcinoma (GBC) patients and may lead to increased survival outcomes. Here, we have applied serological proteome analysis (SERPA), an immuno...

    Authors: Javed Akhtar, Ratna Priya, Vaishali Jain, Puja Sakhuja, Anil Kumar Agarwal, Surbhi Goyal, Ravindra Varma Polisetty, Ravi Sirdeshmukh, Sudeshna Kar and Poonam Gautam

    Citation: BMC Cancer 2020 20:1175

    Content type: Research article

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  24. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Matthias Kröz, Marcus Reif, Augustina Glinz, Bettina Berger, Andreas Nikolaou, Roland Zerm, Benno Brinkhaus, Matthias Girke, Arndt Büssing and Christoph Gutenbrunner

    Citation: BMC Cancer 2020 20:1174

    Content type: Correction

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    The original article was published in BMC Cancer 2017 17:166

  25. Breast cancer (BC) is the most common malignancy in Latin American women, but with a wide variability with respect to their mortality. This study aims to estimate the mortality rates from BC in Peruvian women ...

    Authors: J. Smith Torres-Roman, Jose Fabian Martinez-Herrera, Greta Carioli, Jorge Ybaseta-Medina, Bryan Valcarcel, Joseph A. Pinto, Alfredo Aguilar, Katherine A. McGlynn and Carlo La Vecchia

    Citation: BMC Cancer 2020 20:1173

    Content type: Research article

    Published on:

  26. Routine screening of patients with head and neck squamous cell carcinomas (HNSCCs) for synchronous malignancies using oesophagoscopy and bronchoscopy had been controversial. The aim of this study is therefore ...

    Authors: Shi Yeung Ho and Raymond King Yin Tsang

    Citation: BMC Cancer 2020 20:1172

    Content type: Research article

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  27. The treatment of Ewing sarcoma, an aggressive bone and soft tissue sarcoma, is associated with suboptimal outcomes and significant side-effects. Consequently, there is an urgent need to identify novel therapie...

    Authors: Torin Waters, Kelli L. Goss, Stacia L. Koppenhafer, William W. Terry and David J. Gordon

    Citation: BMC Cancer 2020 20:1171

    Content type: Research article

    Published on:

  28. The most common gender-specific malignancies are cancers of the breast and the prostate. In developing countries, cancer screening of all at risk is impractical because of healthcare resource limitations. Thus...

    Authors: Mahdieh Montazeri, Benyamin Hoseini, Neda Firouraghi, Fatemeh Kiani, Hosein Raouf-Mobini, Adele Biabangard, Ali Dadashi, Vahideh Zolfaghari, Leila Ahmadian, Saeid Eslami, Robert Bergquist, Nasser Bagheri and Behzad Kiani

    Citation: BMC Cancer 2020 20:1170

    Content type: Research article

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  29. The aim of the current study was to evaluate oncologic outcomes of patients who were treated with salvage hysterectomy (HT), compared to systemic chemotherapy (CT) for persistent cervical cancer after definiti...

    Authors: Munetaka Takekuma, Fumiaki Takahashi, Seiji Mabuchi, Wataru Kudaka, Koji Horie, Mariko Ikeda, Ayumi Shikama, Akira Mitsuhashi, Shoji Nagao, Shiro Suzuki, Mika Mizuno, Shin Nishio, Hideki Tokunaga, Yukinobu Ota, Takahiro Kasamatsu, Ryo Kitagawa…

    Citation: BMC Cancer 2020 20:1169

    Content type: Research article

    Published on:

  30. Competing risk method has not been used in a large-scale prospective study to investigate whether increased levels of high-sensitivity C-reactive protein (hs-CRP) elevate the risk of primary liver cancer (PLC)...

    Authors: Sarah Tan Siyin, Tong Liu, Wenqiang Li, Nan Yao, Guoshuai Xu, Jun Qu and Yajun Chen

    Citation: BMC Cancer 2020 20:1168

    Content type: Research article

    Published on:

  31. An increasing number of studies have focused on the association between leptin, adiponectin levels and the risk as well as the prognosis of hepatocellular carcinoma. However, the reported results are conflicting.

    Authors: Lilong Zhang, Qihang Yuan, Man Li, Dongqi Chai, Wenhong Deng and Weixing Wang

    Citation: BMC Cancer 2020 20:1167

    Content type: Research article

    Published on:

  32. Papillary thyroid cancer (PTC) is unique among cancers in that patient age is a consideration in staging. One of the most important modifications in the 8th Edition of the American Joint Committee on Cancer (A...

    Authors: Krzysztof Kaliszewski, Dorota Diakowska, Łukasz Nowak, Beata Wojtczak and Jerzy Rudnicki

    Citation: BMC Cancer 2020 20:1166

    Content type: Research article

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  33. The primary aim was to test the hypothesis that deriving pre-treatment 3D magnetic resonance tumour volume (mrTV) quantification improves performance characteristics for the prediction of loco-regional failure...

    Authors: Hema Sekhar, Rohit Kochhar, Bernadette Carrington, Thomas Kaye, Damian Tolan, Mark P. Saunders, Matthew Sperrin, David Sebag-Montefiore, Marcel van Herk and Andrew G. Renehan

    Citation: BMC Cancer 2020 20:1165

    Content type: Research article

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  34. Preoperative chemoradiotherapy with capecitabine is considered as a standard of care for locally advanced rectal cancer. The “Tratamiento de Tumores Digestivos” group (TTD) previously reported in a randomized ...

    Authors: Ramón Salazar, Jaume Capdevila, Jose Luis Manzano, Carles Pericay, Mercedes Martínez-Villacampa, Carlos López, Ferrán Losa, María José Safont, Auxiliadora Gómez-España, Vicente Alonso-Orduña, Pilar Escudero, Javier Gallego, Beatriz García-Paredes, Amalia Palacios, Sebastiano Biondo, Cristina Grávalos…

    Citation: BMC Cancer 2020 20:1164

    Content type: Research article

    Published on:

  35. Transforming growth factor-β (TGF-β) signaling is a double-edged sword in cancer development and progression. TGF-β signaling plays a tumor suppressive role during the early stages of tumor development but pro...

    Authors: Hwa-Kyung Son, Dokyeong Kim, Yongwoon Lim, Jin Kim and Iha Park

    Citation: BMC Cancer 2020 20:1163

    Content type: Research article

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  36. Aggressive systemic mastocytosis (ASM) is a rare malignant disease characterized by disordered mast cell accumulation in various organs. We here describe a female ASM patient with a previous history of ovarian...

    Authors: Makiko Tsutsumi, Hiroki Miura, Hidehito Inagaki, Yasuko Shinkai, Asuka Kato, Takema Kato, Susumu Hamada-Tsutsumi, Makito Tanaka, Kazuko Kudo, Tetsushi Yoshikawa and Hiroki Kurahashi

    Citation: BMC Cancer 2020 20:1162

    Content type: Research article

    Published on:

  37. Surgical resection is the major way to cure pancreatic ductal adenocarcinoma (PDAC). However, this operation is complex, and the peri-operative risk is high, making patients more likely to be admitted to the i...

    Authors: Yijue Zhang, Sibo Zhu, Zhiqing Yuan, Qiwei Li, Ruifeng Ding, Xunxia Bao, Timing Zhen, Zhiliang Fu, Hailong Fu, Kaichen Xing, Hongbin Yuan and Tao Chen

    Citation: BMC Cancer 2020 20:1161

    Content type: Research article

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  38. Despite advances in early diagnosis and treatment, cancer remains the leading cause of mortality worldwide. The insulin-like growth factor 2 mRNA binding protein (IGF2BP) family has been reported to be involve...

    Authors: Xiao-Han Cui, Shu-Yi Hu, Chun-Fu Zhu and Xi-Hu Qin

    Citation: BMC Cancer 2020 20:1160

    Content type: Research article

    Published on:

  39. Strong evidences support the critical role of Jumonji domain containing 6 (JMJD6) in progression of breast cancer. Here we explore potential partners that coregulate gene expression, to understand additional p...

    Authors: Antara Biswas, Geetashree Mukherjee, Paturu Kondaiah and Kartiki V. Desai

    Citation: BMC Cancer 2020 20:1159

    Content type: Research article

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  40. Human CD133+ hematopoietic progenitor cells (HPCs) are a specific subset of cells that can regulate tumor malignancy. However, the mechanism by which CD133+ HPCs affect the malignancy of human breast cancer ha...

    Authors: Zhe Zhang, Qinglian Zheng, Yonghui Liu, Lianqing Sun, Pingping Han, Rui Wang, Jiao Zhao, Shan Hu and Xinhan Zhao

    Citation: BMC Cancer 2020 20:1158

    Content type: Research article

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  41. Patients with relapsed or refractory peripheral T-cell lymphoma (R/R PTCL) treated with pralatrexate have previously shown superior overall survival (OS) compared to those who underwent conventional chemothera...

    Authors: Seonyoung Park, Ah-Young Kim, Hyeonseok Cho, Deborah Baik, Hankil Lee, Sunghwa Cho and Hye-Young Kang

    Citation: BMC Cancer 2020 20:1157

    Content type: Research article

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  43. To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), and to investigate the role of radiotherapy (RT) in patients with pT1–2N1M0 breast cancer.

    Authors: Guang-Yi Sun, Ge Wen, Yu-Jing Zhang, Yu Tang, Hao Jing, Jian-Yang Wang, Jiang-Hu Zhang, Yong Yang, Xu-Ran Zhao, Si-Ye Chen, Jing Jin, Yong-Wen Song, Yue-Ping Liu, Hui Fang, Hua Ren, Yuan Tang…

    Citation: BMC Cancer 2020 20:1155

    Content type: Research article

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  44. We compared outcomes and toxicities between concurrent retrograde super-selective intra-arterial chemoradiotherapy (IACRT) and concurrent systemic chemoradiotherapy (SCRT) for gingival carcinoma (GC).

    Authors: Yuki Mukai, Yuichiro Hayashi, Izumi Koike, Toshiyuki Koizumi, Madoka Sugiura, Senri Oguri, Shoko Takano, Mitomu Kioi, Mizuki Sato, Kenji Mitsudo and Masaharu Hata

    Citation: BMC Cancer 2020 20:1154

    Content type: Research article

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  45. The aim of this study was to translate and linguistically validate the U.S. National Cancer Institute’s Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) into...

    Authors: Cheng KKF, S. A. Mitchell, N. Chan, E. Ang, W. Tam and R. Kanesvaran

    Citation: BMC Cancer 2020 20:1153

    Content type: Research article

    Published on:

  46. Progressive lung cancer is associated with abnormal coagulation. Platelets play a vital part in evading immune surveillance and angiogenesis in the case of tumor metastasis. The study aimed to analyze the pred...

    Authors: Lu Xu, Fangzhou Xu, Haobo Kong, Meiling Zhao, Yuanzi Ye and Yanbei Zhang

    Citation: BMC Cancer 2020 20:1152

    Content type: Research article

    Published on:

  47. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Alexander Arnold, Moritz Tronser, Christine Sers, Aysel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Matthias Kloor and Hendrik Bläker

    Citation: BMC Cancer 2020 20:1151

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:1038

  48. Metastatic colorectal cancer (mCRC) remains a lethal disease. Survival, however, is increasing due to a growing number of treatment options. Yet due to the number of prognostic factors and their interactions, ...

    Authors: Holger Rumpold, Dora Niedersüß-Beke, Cordula Heiler, David Falch, Helwig Valenting Wundsam, Sigrid Metz-Gercek, Gudrun Piringer and Josef Thaler

    Citation: BMC Cancer 2020 20:1149

    Content type: Research article

    Published on:

  49. When the resected specimen is sent for intraoperative margin assessment, all margins are grossly checked, and selected margins undergo a frozen section (FS) examination. Therefore, there is a possibility of sa...

    Authors: Hana’a Hezam Algadi, Amany Abd-Elhameed Abou-Bakr, Omer Mohammed Jamali and Louloua Mohamed Fathy

    Citation: BMC Cancer 2020 20:1147

    Content type: Research article

    Published on:

  50. The value of postmastectomy radiotherapy (PMRT) for pathological node-positive triple-negative breast cancers (TNBC) remains debatable. The aim of this population-based retrospective study was to evaluate the ...

    Authors: Lei Zhang, Ru Tang, Jia-Peng Deng, Wen-Wen Zhang, Huan-Xin Lin, San-Gang Wu and Zhen-Yu He

    Citation: BMC Cancer 2020 20:1146

    Content type: Database

    Published on:

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