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  1. Aspiration pneumonia is one of the most important side effects of chemoradiotherapy (CRT) and bio-radiotherapy (BRT) in patients with head and neck cancer (HNC). Aspiration pneumonia can lead to cancer-related...

    Authors: Hiromichi Shirasu, Tomoya Yokota, Satoshi Hamauchi, Yusuke Onozawa, Hirofumi Ogawa, Tsuyoshi Onoe, Tetsuro Onitsuka, Takashi Yurikusa, Keita Mori and Hirofumi Yasui

    Citation: BMC Cancer 2020 20:182

    Content type: Research article

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  2. Lymph node metastasis (LNM) occurs frequently in young papillary thyroid carcinoma (PTC) patients, though the mortality rates are low. We aimed to analyze the relationship between age at diagnosis and LNM in P...

    Authors: Yuanchao Liu, Yizeng Wang, Ke Zhao, Dongyang Li, Zuoyu Chen, Ruoyu Jiang, Xiaoning Wang and Xianghui He

    Citation: BMC Cancer 2020 20:181

    Content type: Database

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  3. The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative brea...

    Authors: Guoxuan Gao, Zihan Wang, Xiang Qu and Zhongtao Zhang

    Citation: BMC Cancer 2020 20:179

    Content type: Research article

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  4. Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and p...

    Authors: Yutuan Wu, Shuang Ye, Shyamal Goswami, Xuan Pei, Libing Xiang, Xiaoming Zhang and Huijuan Yang

    Citation: BMC Cancer 2020 20:173

    Content type: Research article

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  5. Silica and asbestos are recognized lung carcinogens. However, their role in carcinogenesis at other organs is less clear. Clearance of inhaled silica particles and asbestos fibers from the lungs may lead to tr...

    Authors: Lidija Latifovic, Paul J. Villeneuve, Marie-Élise Parent, Linda Kachuri and Shelley A. Harris

    Citation: BMC Cancer 2020 20:171

    Content type: Research article

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  6. Bone complications (pathologic fracture, spinal cord compression, surgery to bone and radiation to bone) are a common problem in patients with multiple myeloma (MM). We set out to provide insights into the rea...

    Authors: María-Victoria Mateos, Leah Fink, Niranchana Koneswaran, Michele Intorcia, Christina Giannopoulou, Daniela Niepel and Michele Cavo

    Citation: BMC Cancer 2020 20:170

    Content type: Research article

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  7. Multiple myeloma is a cancer in the bone marrow causing bone destruction. Patients experience various symptoms related to the disease and/or treatment, such as pain and fatigue, leading to poorer quality of li...

    Authors: Rikke Faebo Larsen, Mary Jarden, Lisbeth Rosenbek Minet, Ulf Christian Frølund, Sören Möller and Niels Abildgaard

    Citation: BMC Cancer 2020 20:169

    Content type: Research article

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  8. Following publication of the original article [1], the authors reported an error in the “Samples size calculation and statistical considerations” section.

    Authors: Lilian Schwarz, Dewi Vernerey, Jean-Baptiste Bachet, Jean-Jacques Tuech, Fabienne Portales, Pierre Michel and Antonio Sa Cunha

    Citation: BMC Cancer 2020 20:168

    Content type: Correction

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    The original article was published in BMC Cancer 2018 18:762

  9. Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting.

    Authors: Jin-Hyuk Choi, Yong Won Choi, Seok Yun Kang, Geum Sook Jeong, Hyun Woo Lee, Seong Hyun Jeong, Joon Seong Park, Mi Sun Ahn and Seung Soo Sheen

    Citation: BMC Cancer 2020 20:167

    Content type: Research article

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  10. High rates of venous thromboembolic events (VTEs), mainly in advanced disease, are reported for patients with cancer of the upper gastrointestinal tract (stomach, pancreas) and for treatment with cisplatin.

    Authors: Martin Fehr, Hanne Hawle, Stefanie Hayoz, Peter Thuss-Patience, Sabina Schacher, Jorge Riera Knorrenschild, Donat Dürr, Wolfram T. Knoefel, Holger Rumpold, Michael Bitzer, Martin Zweifel, Panagiotis Samaras, Ulrich Mey, Marc Küng, Ralph Winterhalder, Wolfgang Eisterer…

    Citation: BMC Cancer 2020 20:166

    Content type: Research article

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  11. Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators (“writer,” ...

    Authors: Nanfang Qu, Sanyu Qin, Xuemei Zhang, Xiaotong Bo, Zhengchun Liu, Chao Tan, Guiqiong Wen and Haixing Jiang

    Citation: BMC Cancer 2020 20:165

    Content type: Research article

    Published on:

  12. Following publication of the original article [1], an error was reported in the tagging of Joël Fokom Domgue in the author group. The tagging in this correction article has been fixed.

    Authors: Hong Lou, Eduardo Gharzouzi, Sarita Polo Guerra, Joël Fokom Domgue, Julie Sawitzke, Guillermo Villagran, Lisa Garland, Joseph F. Boland, Sarah Wagner, Héctor Rosas, Jami Troxler, Heidi McMillen, Bailey Kessing, Enrique Alvirez, Miriam Castillo, Hesler Morales…

    Citation: BMC Cancer 2020 20:164

    Content type: Correction

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    The original article was published in BMC Cancer 2018 18:562

  13. Following publication of the original article [1], the authors reported an error in the authorship list associated with the paper. Georgina McPherson has therefore been added.

    Authors: Naomi Brewer, Karen Bartholomew, Anna Maxwell, Jane Grant, Georgina McPherson, Helen Wihongi, Collette Bromhead, Nina Scott, Sue Crengle, Chris Cunningham, Jeroen Douwes and John D. Potter

    Citation: BMC Cancer 2020 20:163

    Content type: Correction

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    The original article was published in BMC Cancer 2019 19:1198

  14. The prognostic nutritional index (PNI), which is an easily calculated nutritional index, is significantly associated with patient outcomes in various solid malignancies. This study aimed to evaluate the progno...

    Authors: Takaaki Oba, Kazuma Maeno, Daiya Takekoshi, Mayu Ono, Tokiko Ito, Toshiharu Kanai and Ken-ichi Ito

    Citation: BMC Cancer 2020 20:160

    Content type: Research article

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  15. Lung cancer is the major malignant tumour. The present study was conducted to determine the expression level of syntenin in lung cancer tissues and serum from lung cancer patients and to explore its clinical s...

    Authors: Pengyong Luo, Xuli Yang, Shiren Huang, Shu Feng and Zongxing Ou

    Citation: BMC Cancer 2020 20:159

    Content type: Research article

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  16. Cancer-related fatigue (CRF) is one of the most prevalent complications experienced by cancer patients during and after the process of treatment. Despite conducting a lot of studies, there is no approved thera...

    Authors: Ebrahim Salehifar, Saeid Azimi, Ghasem Janbabai, Ehsan Zaboli, Narjes Hendouei, Fatemeh Saghafi and Samaneh Borhani

    Citation: BMC Cancer 2020 20:158

    Content type: Research article

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  17. Rash is one of the most common severe adverse events associated with use of vemurafenib for the treatment of melanoma, either as monotherapy or in combination with cobimetinib. The study aimed to identify pre-...

    Authors: Ashley M. Hopkins, Akash D. Rathod, Andrew Rowland, Ganessan Kichenadasse and Michael J. Sorich

    Citation: BMC Cancer 2020 20:157

    Content type: Research article

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  18. A BRAF V600E mutation is found as driver oncogene in patients with non-small cell lung cancer. Although combined treatment with dabrafenib and trametinib is highly effective, the efficacy of reduced doses of the ...

    Authors: Yuta Adachi, Naohiro Yanagimura, Chiaki Suzuki, Sakiko Ootani, Azusa Tanimoto, Akihiro Nishiyama, Kaname Yamashita, Koushiro Ohtsubo, Shinji Takeuchi and Seiji Yano

    Citation: BMC Cancer 2020 20:156

    Content type: Case report

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  19. Gemcitabine/erlotinib treatment offers limited benefit in unselected patients with pancreatic ductal adenocarcinoma (PDAC). Development of skin rash has been associated with favorable outcomes in patients trea...

    Authors: C. Benedikt Westphalen, Tobias Kukiolka, Benjamin Garlipp, Lars Hahn, Martin Fuchs, Peter Malfertheiner, Marcel Reiser, Fabian Kütting, Volker Heinemann, Andreas Beringer and Dirk T. Waldschmidt

    Citation: BMC Cancer 2020 20:155

    Content type: Research article

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  20. Cancer recurrence is one of the most concerning clinical problems of cholangiocarcinoma (CCA) patients after treatment. However, an identification of predictive factor on Opisthorchis viverrini (OV)-associated CC...

    Authors: Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun and Watcharin Loilome

    Citation: BMC Cancer 2020 20:154

    Content type: Research article

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  21. There is a discrepancy about the metastatic rate of internal mammary lymph nodes (IMNs) between clinical and pathologic findings. We aimed to investigate the metastatic rate of IMNs and to provide recommendati...

    Authors: Li Li, Hongyan Zhang, Linwei Wang, Conghua Xie, Yunfeng Zhou and Yahua Zhong

    Citation: BMC Cancer 2020 20:153

    Content type: Research article

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  22. Despite recent advances in diagnosis and treatment, cervical cancer continues to be a significant health problem worldwide. Whereas robot-assisted surgery has advantages over the abdominal approach, and minima...

    Authors: Kyung Jin Eoh, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim and Young Tae Kim

    Citation: BMC Cancer 2020 20:152

    Content type: Research article

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  23. Alteration in gut microbiota has been recently linked with childhood leukemia and the use of chemotherapy. Whether the perturbed microbiota community is restored after disease remission and cessation of cancer...

    Authors: Ling Ling Chua, Reena Rajasuriar, Yvonne Ai Lian Lim, Yin Ling Woo, P’ng Loke and Hany Ariffin

    Citation: BMC Cancer 2020 20:151

    Content type: Research article

    Published on:

  24. To investigate clinicopathological variables influencing overall survival, overall recurrence, and post-recurrence survival (PRS) in patients who experienced curative-intent surgical resection of stage I non-s...

    Authors: Chengdi Wang, Yuxuan Wu, Jun Shao, Dan Liu and Weimin Li

    Citation: BMC Cancer 2020 20:150

    Content type: Research article

    Published on:

  25. It remains controversial whether prophylactic No.10 lymph node clearance is necessary for gastric cancer. Thus, the present study aims to investigate the impact of prophylactic No.10 lymph node clearance on th...

    Authors: Gaozan Zheng, Jinqiang Liu, Yinghao Guo, Fei Wang, Shushang Liu, Guanghui Xu, Man Guo, Xiao Lian, Hongwei Zhang and Fan Feng

    Citation: BMC Cancer 2020 20:149

    Content type: Research article

    Published on:

  26. Lung adenocarcinoma (LAC) is composed of lepidic, papillary, mucinous, micropapillary and solid components in its parenchyma. Complex responses to therapeutics result from intratumoral heterogeneity. However, ...

    Authors: Yiran Cai, Hongbo Wu, Xiaoqin Shi, Yujie Dong, Xiujun Chang, Li Zhang, Lijuan Zhou, Dan Su and Ming Yang

    Citation: BMC Cancer 2020 20:148

    Content type: Research article

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  27. Brain metastases often occur in cancer evolution. They are not only responsible for death but also for disorders affecting the quality of life and the cognitive functions.

    Authors: Paul Lesueur, William Kao, Alexandra Leconte, Julien Geffrelot, Justine Lequesne, Joëlle Lacroix, Pierre-Emmanuel Brachet, Ioana Hrab, Philippe Royer, Bénédicte Clarisse and Dinu Stefan

    Citation: BMC Cancer 2020 20:147

    Content type: Study protocol

    Published on:

  28. To evaluate and compare the prognostic performance of four nutritional indicators body mass index (BMI), serum albumin (ALB), prognostic nutritional index (PNI) and nutritional risk index (NRI) in oral cancer ...

    Authors: Xiaodan Bao, Fengqiong Liu, Jing Lin, Qing Chen, Lin Chen, Fa Chen, Jing Wang, Yu Qiu, Bin Shi, Lizhen Pan, Lisong Lin and Baochang He

    Citation: BMC Cancer 2020 20:146

    Content type: Research article

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  29. Aberrant JAK/STAT activation has been detected in many types of human cancers. The role of JAK/STAT activation in cancer has been mostly attributed to direct transcriptional regulation of target genes by phosp...

    Authors: Pranabananda Dutta, Lin Zhang, Huijun Zhang, Qin Peng, Phillippe R. Montgrain, Yingxiao Wang, Yuanlin Song, Jinghong Li and Willis X. Li

    Citation: BMC Cancer 2020 20:145

    Content type: Research article

    Published on:

  30. Information on the optimal salvage regimen for recurrent esophageal cancer is scarce. We aimed to assess the patterns of locoregional failure, and evaluate the therapeutic efficacy of salvage therapy along wit...

    Authors: Wenjie Ni, Jinsong Yang, Wei Deng, Zefen Xiao, Zongmei Zhou, Hongxing Zhang, Dongfu Chen, Qinfu Feng, Jun Liang, Jima Lv, Xiaozhen Wang, Xin Wang, Tao Zhang, Nan Bi, Lei Deng and Wenqing Wang

    Citation: BMC Cancer 2020 20:144

    Content type: Research article

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  31. MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene expression regulation and have been described as key regulators of carcinogenesis. Aberrant miRNA expression has been frequent...

    Authors: Danielle Pessôa-Pereira, Adriane Feijó Evangelista, Rhafaela Lima Causin, René Aloisio da Costa Vieira, Lucas Faria Abrahão-Machado, Iara Viana Vidigal Santana, Vinicius Duval da Silva, Karen Cristina Borba de Souza, Renato José de Oliveira-Silva, Gabriela Carvalho Fernandes, Rui Manuel Reis, Edenir Inêz Palmero and Márcia Maria Chiquitelli Marques

    Citation: BMC Cancer 2020 20:143

    Content type: Research article

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  32. Thoracic epidural analgesia is the standard postoperative pain management strategy in esophageal cancer surgery. However, paravertebral block analgesia may achieve comparable pain control while inducing less s...

    Authors: B. F. Kingma, W. J. Eshuis, E. M. de Groot, M. L. Feenstra, J. P. Ruurda, S. S. Gisbertz, W. ten Hoope, M. Marsman, J. Hermanides, M. W. Hollmann, C. J. Kalkman, M. D. P. Luyer, G. A. P. Nieuwenhuijzen, H. J. Scholten, M. Buise, M. J. van Det…

    Citation: BMC Cancer 2020 20:142

    Content type: Study protocol

    Published on:

  33. The term triple-negative breast cancer (TNBC) is used to describe breast cancers without expression of estrogen receptor, progesterone receptor or HER2 amplification. To advance targeted treatment options for ...

    Authors: Karel Kalecky, Rebecca Modisette, Samantha Pena, Young-Rae Cho and Joseph Taube

    Citation: BMC Cancer 2020 20:141

    Content type: Research article

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  34. Whether or not double J (DJ) stenting during transurethral resection of a bladder tumour (TURBT) harms patients with regard to possible metachronous upper urinary tract urothelial cancer (UUTUC) development re...

    Authors: Marie C. Hupe, Lukas Dormayer, Tomasz Ozimek, Julian P. Struck, Martin J. P. Hennig, Melanie Klee, Christoph A. J. von Klot, Markus A. Kuczyk, Axel S. Merseburger and Mario W. Kramer

    Citation: BMC Cancer 2020 20:140

    Content type: Research article

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  35. There is inconsistent evidence on the association between physical activity and pancreatic cancer risk and few studies have investigated early life or life-course physical activity. The objective of this study...

    Authors: Jaspreet Sandhu, Vanessa De Rubeis, Michelle Cotterchio, Brendan T. Smith, Lauren E. Griffith, Darren R. Brenner, Ayelet Borgida, Steven Gallinger, Sean Cleary and Laura N. Anderson

    Citation: BMC Cancer 2020 20:139

    Content type: Research article

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  36. To study the kinetic profile and clinicopathological implications of squamous cell carcinoma antigen (SCC-Ag) in cervical cancer patients who underwent surgery by a self-developed SCC-Ag single molecule assay ...

    Authors: Shuang Ye, Xiaohua Sun, Bin Kang, Fei Wu, Zhong Zheng, Libing Xiang, Mylène Lesénéchal, Fabienne Heskia, Ji Liang and Huijuan Yang

    Citation: BMC Cancer 2020 20:138

    Content type: Research article

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  37. In a previous study (Goebel et. al, Cancer Genomics Proteomics 16:229-244, 2019), we identified 33 biomarkers for an early stage (I-II) Non-Small Cell Lung Cancer (NSCLC) test with 90% accuracy, 80.3% sensitiv...

    Authors: Cherylle Goebel, Christopher L. Louden, Robert Mckenna Jr, Osita Onugha, Andrew Wachtel and Thomas Long

    Citation: BMC Cancer 2020 20:137

    Content type: Research article

    Published on:

  38. The benefit of adjuvant chemotherapy in invasive lobular carcinoma (ILC) is still unclear. The objective of the current study was to elucidate the effectiveness of adjuvant chemotherapy in hormone receptor (HR...

    Authors: Guangfu Hu, Guangxia Hu, Chengjiao Zhang, Xiaoyan Lin, Ming Shan, Yanmin Yu, Yongwei Lu, Ruijie Niu, Hui Ye, Cheng Wang and Cheng Xu

    Citation: BMC Cancer 2020 20:136

    Content type: Research article

    Published on:

  39. Overweight/obesity are strongly implicated in breast cancer development, and weight gain post-diagnosis is associated with greater morbidity and all-cause mortality. The aim of this study was to describe the p...

    Authors: Carolyn Ee, Adele Elizabeth Cave, Dhevaksha Naidoo, Kellie Bilinski and John Boyages

    Citation: BMC Cancer 2020 20:113

    Content type: Research article

    Published on:

  40. Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable. Locoregional therapies inducing i...

    Authors: Ligia Craciun, Roland de Wind, Pieter Demetter, Valerio Lucidi, Ali Bohlok, Sébastien Michiels, Fikri Bouazza, Michael Vouche, Ilario Tancredi, Gontran Verset, Soizic Garaud, Céline Naveaux, Maria Gomez Galdon, Karen Willard Gallo, Alain Hendlisz, Ivan Duran Derijckere…

    Citation: BMC Cancer 2020 20:135

    Content type: Research article

    Published on:

  41. Diffusion weighted magnetic resonance imaging (DW-MRI) holds great potential for monitoring treatment response in cancer patients shortly after initiation of radiotherapy. It is hypothesized that a decrease in...

    Authors: Frederikke Petrine Fliedner, Trine Bjørnbo Engel, Henrik H. El-Ali, Anders Elias Hansen and Andreas Kjaer

    Citation: BMC Cancer 2020 20:134

    Content type: Research article

    Published on:

  42. The importance of ACF is not fully explained, however, their number may be a good predictor of synchronous and metachronic adenoma or other polyps whose removal reduces the risk of CRC. Due to the epidemiologi...

    Authors: Marek Kowalczyk, Marcin Orłowski, Łukasz Klepacki, Krzysztof Zinkiewicz, Waldemar Kurpiewski, Dorota Kaczerska, Wiesław Pesta, Ewa Zieliński and Piotr Siermontowski

    Citation: BMC Cancer 2020 20:133

    Content type: Research article

    Published on:

  43. Microvascular invasion (MVI) is an independent risk factor for poor prognosis in hepatocellular carcinoma (HCC). However, there is still a lack of preoperative markers to predict MVI in HCC. This study intends...

    Authors: Hongxing Zhang, Yu Zhou, Yicheng Li, Wanying Qin, Yunhua Zi, Yulan Liu, Xiaoying Qiu, Hongyuan Xu, Weijia Liao and Zhaoquan Huang

    Citation: BMC Cancer 2020 20:132

    Content type: Research article

    Published on:

  44. Colorectal cancer (CRC) is the third most prevalent cancer in China but few large-scale studies were conducted to understand CRC patients. The current study is aimed to gain a real-world perspectives of CRC pa...

    Authors: Ruihua Xu, Wei Wang, Bo Zhu, Xiaoyan Lin, Dong Ma, Lingjun Zhu, Qingchuan Zhao, Yongzhan Nie, Xiaohong Cai, Qi Li, Weijia Fang, Hongyan Li, Ning Wang, Yun Chen, Cike Peng, Honghao Fang…

    Citation: BMC Cancer 2020 20:131

    Content type: Research article

    Published on:

  45. Preoperative chemoradiotherapy (CRT) followed by surgery is the most common approach for patients with resectable esophageal cancer. Nevertheless, considerable numbers of esophageal-cancer patients undergo sur...

    Authors: Wenjie Ni, Shufei Yu, Wencheng Zhang, Zefen Xiao, Zongmei Zhou, Dongfu Chen, Qinfu Feng, Jun Liang, Jima Lv, Shugeng Gao, Yousheng Mao, Qi Xue, Kelin Sun, Xiangyang Liu, Dekang Fang, Jian Li…

    Citation: BMC Cancer 2020 20:130

    Content type: Study protocol

    Published on:

  46. Colorectal cancer (CRC) is a heterogeneous disease with a complex biology and a wide number of altered genes such as BRAF, KRAS and PIK3CA. Advances with new-targeted therapies have been achieved and available...

    Authors: Evelina Miele, Luana Abballe, Gian Paolo Spinelli, Zein Mersini Besharat, Giuseppina Catanzaro, Martina Chiacchiarini, Alessandra Vacca, Agnese Po, Carlo Capalbo and Elisabetta Ferretti

    Citation: BMC Cancer 2020 20:129

    Content type: Research article

    Published on:

  47. Following publication of the original article [1], the authors reported that the family name of the author, Ludovica Baldari, was misspelled.

    Authors: Igor Monsellato, Filippo Alongi, Elisa Bertocchi, Stefania Gori, Giacomo Ruffo, Elisa Cassinotti, Ludovica Baldari, Luigi Boni, Graziano Pernazza, Fabio Pulighe, Carlo De Nisco, Roberto Perinotti, Emilio Morpurgo, Tania Contardo, Enzo Mammano, Ugo Elmore…

    Citation: BMC Cancer 2020 20:128

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2019 19:1215

  48. Tumor microenvironment (TME) including the immune checkpoint system impacts prognosis in some types of malignancy. The aim of our study was to investigate the precise prognostic significance of the TME profile...

    Authors: Shuang Zhang, Takeo Minaguchi, Chenyang Xu, Nan Qi, Hiroya Itagaki, Ayumi Shikama, Nobutaka Tasaka, Azusa Akiyama, Manabu Sakurai, Hiroyuki Ochi and Toyomi Satoh

    Citation: BMC Cancer 2020 20:127

    Content type: Research article

    Published on:

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