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  1. Financial toxicity of cancer has so far been discussed primarily in the US health care system and is associated with higher morbidity and mortality. In European health care systems, the socio-economic impact o...

    Authors: Katja Mehlis, Julian Witte, Bastian Surmann, Matthias Kudlich, Leonidas Apostolidis, Jürgen Walther, Dirk Jäger, Wolfgang Greiner and Eva C. Winkler

    Citation: BMC Cancer 2020 20:529

    Content type: Research article

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  3. Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients. Generally, leukemia patients differ in their sensitivity to L-asparagina...

    Authors: Katerina Hlozkova, Alena Pecinova, Natividad Alquezar-Artieda, David Pajuelo-Reguera, Marketa Simcikova, Lenka Hovorkova, Katerina Rejlova, Marketa Zaliova, Tomas Mracek, Alexandra Kolenova, Jan Stary, Jan Trka and Julia Starkova

    Citation: BMC Cancer 2020 20:526

    Content type: Research article

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  4. Xenograft mouse tumor models are used to study mechanisms of tumor growth and metastasis formation and to investigate the efficacy of different therapeutic interventions. After injection the engrafted cells fo...

    Authors: Bertin Hoffmann, Tobias Lange, Vera Labitzky, Kristoffer Riecken, Andreas Wree, Udo Schumacher and Gero Wedemann

    Citation: BMC Cancer 2020 20:524

    Content type: Research article

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  5. Pediatric patients with relapsed or refractory disease represent a population with a desperate medical need. The aim of the INFORM (INdividualized Therapy FOr Relapsed Malignancies in Childhood) program is to ...

    Authors: Cornelis M. van Tilburg, Ruth Witt, Melanie Heiss, Kristian W. Pajtler, Christoph Plass, Isabel Poschke, Michael Platten, Inga Harting, Oliver Sedlaczek, Angelika Freitag, David Meyrath, Lenka Taylor, Gnana Prakash Balasubramanian, Natalie Jäger, Elke Pfaff, Barbara C. Jones…

    Citation: BMC Cancer 2020 20:523

    Content type: Study protocol

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  6. Octamer-binding transcription factor 4A (OCT4A) is essential for cell pluripotency and reprogramming both in humans and mice. To date, however, the function of human OCT4 in somatic and/or tumour tissues is la...

    Authors: Seijiro Koshimune, Mitsuko Kosaka, Nobuhiko Mizuno, Hiromasa Yamamoto, Tomoyuki Miyamoto, Kohta Ebisui, Shinichi Toyooka and Aiji Ohtsuka

    Citation: BMC Cancer 2020 20:521

    Content type: Research article

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  7. Chemoradiotherapy (CRT) with high cumulative doses (CDs) of cisplatin has been considered the standard of care for non-metastatic nasopharyngeal carcinoma (NPC). However, given most patients’ inability to tole...

    Authors: Nuttapong Ngamphaiboon, Arunee Dechaphunkul, Jiraporn Setakornnukul, Tanadech Dechaphunkul, Rungarun Jiratrachu, Bhoom Suktitipat, Chuleeporn Jiarpinitnun, Poompis Pattaranutaporn and Pongwut Danchaivijitr

    Citation: BMC Cancer 2020 20:518

    Content type: Research article

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  8. Although many studies have identified several inflammation-based and/or nutritional markers with prognostic value for patients with various types of cancer, the optimal markers and cut-off values for these mar...

    Authors: Takahiro Toyokawa, Kazuya Muguruma, Mami Yoshii, Tatsuro Tamura, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Shigeru Lee, Masakazu Yashiro and Masaichi Ohira

    Citation: BMC Cancer 2020 20:517

    Content type: Research article

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  9. Trichilemmal carcinoma (TC) is an extremely rare hair follicle tumor. We aimed to explore the genetic abnormalities involved in TC to gain insight into its molecular pathogenesis.

    Authors: Jeong Hyun Ha, Cheol Lee, Kyu Sang Lee, Chang-sik Pak, Choong-Hyun Sun, Youngil Koh and Hak Chang

    Citation: BMC Cancer 2020 20:516

    Content type: Research article

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  10. FOLFIRINOX is a pillar first-line regimen in the treatment of pancreatic cancer. Historically, biliary tract cancer (BTC) and pancreatic cancer have been treated similarly with gemcitabine alone or combined wi...

    Authors: Ayhan Ulusakarya, Abdoulaye Karaboué, Oriana Ciacio, Gabriella Pittau, Mazen Haydar, Pamela Biondani, Yusuf Gumus, Amale Chebib, Wathek Almohamad and Pasquale F. Innominato

    Citation: BMC Cancer 2020 20:515

    Content type: Research article

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  11. Morcellation may lead to intraperitoneal spread of tumor cells, thus making prognosis of undiagnosed uterine leiomyosarcoma (ULMS) worse. However, preoperative diagnosis of ULMS remains challenging. This study...

    Authors: Guorui Zhang, Xin Yu, Lan Zhu, Qingbo Fan, Honghui Shi and Jinghe Lang

    Citation: BMC Cancer 2020 20:514

    Content type: Research article

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  12. Invasion is often found during postoperative pathological examination of cases diagnosed as ductal carcinoma in situ (DCIS) by histological examinations such as core needle biopsy (CNB) or vacuum-assisted biop...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Tamami Morisaki, Katsuyuki Takahashi, Hisakazu Fujita, Tsutomu Takashima, Shuhei Tomita, Kosei Hirakawa and Masaichi Ohira

    Citation: BMC Cancer 2020 20:513

    Content type: Research article

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  13. Luminal breast cancer (L-BCa) comprises the majority of incurable, distally metastatic breast cancer cases. Estrogen supports growth of L-BCa cells but suppresses invasiveness. Estrogen also induces the proges...

    Authors: Rayna Rosati, Kailey Oppat, Yanfang Huang, Seongho Kim and Manohar Ratnam

    Citation: BMC Cancer 2020 20:512

    Content type: Research article

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  14. The clinical significance of GLI1 expression either through canonical Hedgehog signal transduction or through non-canonical mechanisms in rhabdomyosarcoma (RMS) or Ewing sarcoma (EWS) is incompletely understood. ...

    Authors: Joon Won Yoon, Marilyn Lamm, Christopher Chandler, Philip Iannaccone and David Walterhouse

    Citation: BMC Cancer 2020 20:511

    Content type: Research article

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  15. 18 F-FDG is a glucose analogue whose metabolic index SUV can effectively reflect the metabolic level of tumor microenvironment. Aspirin can affect the uptake of 18F-FDG by cancer cells, reducing the SUVmax val...

    Authors: Jinghua Chen, Junxian Xia, Jiacheng Huang and Ruilian Xu

    Citation: BMC Cancer 2020 20:510

    Content type: Research article

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  17. Whilst epidemiological studies have provided evidence of associations between certain risk factors and glioma onset, inferring causality has proven challenging. Using Mendelian randomization (MR), we assessed ...

    Authors: A. E. Howell, J. W. Robinson, R. E. Wootton, A. McAleenan, S. Tsavachidis, Q. T. Ostrom, M. Bondy, G. Armstrong, C. Relton, P. Haycock, R. M. Martin, J. Zheng and K. M. Kurian

    Citation: BMC Cancer 2020 20:508

    Content type: Research article

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  18. PARP inhibitors (PARPi) have recently been approved for various malignancies based on the results of several clinical trials. However, these trials have mostly recruited patients with germline BRCA mutations, ...

    Authors: Ghulam Rehman Mohyuddin, Muhammad Aziz, Alec Britt, Lee Wade, Weijing Sun, Joaquina Baranda, Raed Al-Rajabi, Anwaar Saeed and Anup Kasi

    Citation: BMC Cancer 2020 20:507

    Content type: Research article

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  19. Recent studies have extensively investigated the roles of miR-106 in colorectal cancer (CRC). However, the associations and molecular mechanism underlying the roles of miR-106 in CRC remain unclear. We aimed t...

    Authors: Qiliang Peng, Yi Shen, Peifeng Zhao, Ming Cheng, Yaqun Zhu and Bo Xu

    Citation: BMC Cancer 2020 20:506

    Content type: Research article

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  20. Triple Negative breast cancer (TNBC) includes a heterogeneous group of tumors with different clinico-pathological features, molecular alterations and treatment responsivity. Our aim was to evaluate the clinico...

    Authors: Francesca Sanges, Matteo Floris, Paolo Cossu-Rocca, Maria R. Muroni, Giovanna Pira, Silvana Anna Maria Urru, Renata Barrocu, Silvano Gallus, Cristina Bosetti, Maurizio D’Incalci, Alessandra Manca, Maria Gabriela Uras, Ricardo Medda, Elisabetta Sollai, Alma Murgia, Dolores Palmas…

    Citation: BMC Cancer 2020 20:491

    Content type: Research article

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  21. Stomach cancer (SC) is a type of cancer, which is derived from the stomach mucous membrane. As there are non-specific symptoms or no noticeable symptoms observed at the early stage, newly diagnosed SC cases us...

    Authors: Erli Gu, Wei Song, Ajing Liu and Hong Wang

    Citation: BMC Cancer 2020 20:490

    Content type: Database

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  22. The objective of this study was to develop a practical nomogram for predicting the cancer-specific survival (CSS) of patients with small-intestine adenocarcinoma.

    Authors: Na Wang, Jin Yang, Jun Lyu, Qingqing Liu, Hairong He, Jie Liu, Li Li, Xuequn Ren and Zhendong Li

    Citation: BMC Cancer 2020 20:505

    Content type: Research article

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  23. The decision of transarterial chemoembolization (TACE) initiation and/or repetition remains challenging in patients with unresectable hepatocellular carcinoma (HCC). The aim was to develop a prognostic scoring...

    Authors: Joon Yeul Nam, A Reum Choe, Dong Hyun Sinn, Jeong-Hoon Lee, Hwi Young Kim, Su Jong Yu, Yoon Jun Kim, Jung-Hwan Yoon, Jeong Min Lee, Jin Wook Chung, Sun Young Choi, Jeong Kyong Lee, Seung Yon Baek, Hye Ah Lee, Tae Hun Kim and Kwon Yoo

    Citation: BMC Cancer 2020 20:504

    Content type: Research article

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  24. Esophagogastric adenocarcinoma (EGA) currently represents a main cause of cancer related death. Despite an intensified treatment for locally advanced or metastatic EGA with a doublet chemotherapy consisting of...

    Authors: Joseph Tintelnot, Eray Goekkurt, Mascha Binder, Peter Thuss-Patience, Sylvie Lorenzen, Jorge Riera Knorrenschild, Albrecht Kretzschmar, Thomas Ettrich, Udo Lindig, Lutz Jacobasch, Daniel Pink, Salah-Eddin Al-Batran, Axel Hinke, Susanna Hegewisch-Becker, Sven Nilsson, Carsten Bokemeyer…

    Citation: BMC Cancer 2020 20:503

    Content type: Study protocol

    Published on:

  25. Early radiation-induced temporal lobe injury (RTLI) diagnosis in nasopharyngeal carcinoma (NPC) is clinically challenging, and prediction models of RTLI are lacking. Hence, we aimed to develop radiomic models ...

    Authors: Bin Zhang, Zhouyang Lian, Liming Zhong, Xiao Zhang, Yuhao Dong, Qiuying Chen, Lu Zhang, Xiaokai Mo, Wenhui Huang, Wei Yang and Shuixing Zhang

    Citation: BMC Cancer 2020 20:502

    Content type: Research article

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  26. The aim of our study was to assess the feasibility and oncologic outcomes in patients treated with spinal (SI) or craniospinal irradiation (CSI) in patients with leptomeningeal metastases (LM) and to suggest a...

    Authors: Michal Devecka, Marciana Nona Duma, Jan J. Wilkens, Severin Kampfer, Kai Joachim Borm, Stefan Münch, Christoph Straube and Stephanie E. Combs

    Citation: BMC Cancer 2020 20:501

    Content type: Research article

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  27. Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification.

    Authors: Matthew P. Humphries, Stephanie G. Craig, Rafal Kacprzyk, Natalie C. Fisher, Victoria Bingham, Stephen McQuaid, Graeme I. Murray, Damian McManus, Richard C. Turkington, Jacqueline James and Manuel Salto-Tellez

    Citation: BMC Cancer 2020 20:500

    Content type: Research article

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  28. To investigate the performance of primary ultrasound (P-US) screening for breast cancer, and that of supplemental ultrasound (S-US) screening for breast cancer after negative mammography (MAM).

    Authors: Lei Yang, Shengfeng Wang, Liwen Zhang, Chao Sheng, Fengju Song, Ping Wang and Yubei Huang

    Citation: BMC Cancer 2020 20:499

    Content type: Research article

    Published on:

  29. Addition of oxaliplatin to capecitabine remains controversial for locally advanced rectal cancer (LARC). And cumulative oxaliplatin dose (COD) varied among clinical trials showing different therapeutic effects...

    Authors: Hui Chang, Ya-lan Tao, Wu Jiang, Chen Chen, Shi-liang Liu, Wei-jun Ye and Yuan-hong Gao

    Citation: BMC Cancer 2020 20:498

    Content type: Research article

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  30. MassARRAY (Agena Bioscience™) combines competitive PCR with MALDI-TOF mass spectrometry (MS) analysis that gives highly accurate, sensitive, and high-throughput methods for the quantitative analysis of variati...

    Authors: Ruchi Shah, Varun Sharma, Amrita Bhat, Hemender Singh, Indu Sharma, Sonali Verma, Gh. Rasool Bhat, Bhanu Sharma, Divya Bakshi, Rakesh Kumar and Nazir Ahmed Dar

    Citation: BMC Cancer 2020 20:497

    Content type: Research article

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  31. For epidemiological research, cancer registry datasets often need to be augmented with additional data. Data linkage is not feasible when there are no cases in common between data sets. We present a novel appr...

    Authors: Paul P. Fahey, Andrew Page, Glenn Stone and Thomas Astell-Burt

    Citation: BMC Cancer 2020 20:496

    Content type: Research article

    Published on:

  32. Patients suffering from cancers are increasingly numerous in general practice consultations. The General Practitioner (GP) should be at the heart of the management of patients. Several studies have examined th...

    Authors: Vladimir Druel, Laetitia Gimenez, Kim Paricaud, Jean-Pierre Delord, Pascale Grosclaude, Nathalie Boussier and Marie-Eve Rougé Bugat

    Citation: BMC Cancer 2020 20:495

    Content type: Research article

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  33. Bone metastasis (BM) is one of the common sites of hepatocellular carcinoma (HCC), and the prognosis of BM patients is worse than patients without it. Our study aimed to identify predictors and prognostic fact...

    Authors: Chuan Hu, Jiaxin Yang, Zhangheng Huang, Chuan Liu, Yijun Lin, Yuexin Tong, Zhiyi Fan, Bo Chen, Cailin Wang and Cheng-Liang Zhao

    Citation: BMC Cancer 2020 20:494

    Content type: Research article

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  34. Numerous studies conducted over the past 30 years have pointed to the presence of Epstein–Barr virus (EBV) in gastric cancer samples. This study was aimed to provide a meta-analytic review of the prevalence of...

    Authors: Ahmad Tavakoli, Seyed Hamidreza Monavari, Farid Solaymani Mohammadi, Seyed Jalal Kiani, Saber Armat and Mohammad Farahmand

    Citation: BMC Cancer 2020 20:493

    Content type: Research article

    Published on:

  35. Metastasis directed therapy (MDT) for patients with oligometastatic disease is associated with improvements in progression free survival (PFS) and overall survival (OS) compared to systemic therapy alone. Addi...

    Authors: Hamza Hasan, Matthew P. Deek, Ryan Phillips, Robert F. Hobbs, Reem Malek, Noura Radwan, Ana P. Kiess, Shirl Dipasquale, James Huang, Terry Caldwell, Jessica Leitzel, Danielle Wendler, Hao Wang, Elizabeth Thompson, Jonathan Powell, Sara Dudley…

    Citation: BMC Cancer 2020 20:492

    Content type: Study protocol

    Published on:

  36. The prevalences of diabetes mellitus and hypertension, both of which are components of metabolic syndrome, are known to be increased among patients with multiple myeloma (MM), but remain undetermined among pat...

    Authors: Efrat Markus, Svetlana Trestman, Yael Cohen, Yoel Angel, Yael Sofer, Moshe Mittelman, Irit Avivi, Naftali Stern and Elena Izkhakov

    Citation: BMC Cancer 2020 20:489

    Content type: Research article

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  37. Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study we...

    Authors: Yngvar Nilssen, Odd Terje Brustugun, Morten Tandberg Eriksen, Erik Skaaheim Haug, Bjørn Naume and Bjørn Møller

    Citation: BMC Cancer 2020 20:488

    Content type: Research article

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  38. The influence of perioperative blood transfusion (PBT) on postsurgical survival of patients with different stage of hepatocellular carcinoma (HCC) is not well clarified. This study aimed to evaluate the impact...

    Authors: Gui-Xing Chen, Chao-Ying Qi, Wen-Jie Hu, Xiao-Hui Wang, Yun-Peng Hua, Ming Kuang, Bao-Gang Peng and Shao-Qiang Li

    Citation: BMC Cancer 2020 20:487

    Content type: Research article

    Published on:

  39. Thousands of research articles on neuroblastoma have been published over the past few decades; however, the heterogeneity and variable quality of scholarly data may challenge scientists or clinicians to survey...

    Authors: Illya Martynov, Jessica Klima-Frysch and Joachim Schoenberger

    Citation: BMC Cancer 2020 20:486

    Content type: Research article

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  40. Preoperative radiochemotherapy (RCT) is recommended in France prior to total mesorectal excision in patients with mid or low locally advanced rectal cancer (LARC) (cT3/T4 and/or N+) because it has been shown t...

    Authors: Antoine Brouquet, Jean-Baptiste Bachet, Florence Huguet, Mehdi Karoui, Pascal Artru, Charles Sabbagh, Jérémie H. Lefèvre, Dewi Vernerey, Christophe Mariette, Eric Vicaut and Stephane Benoist

    Citation: BMC Cancer 2020 20:485

    Content type: Study protocol

    Published on:

  41. It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet. Up to 43% of these women are at ris...

    Authors: U. Olsson Möller, L. Rydén and M. Malmström

    Citation: BMC Cancer 2020 20:484

    Content type: Study protocol

    Published on:

  42. Repeat transarterial chemoembolisation (rTACE) is often required for hepatocellular carcinoma (HCC) to achieve disease control, however, current practice guidelines regarding treatment allocation vary signific...

    Authors: Gauri Mishra, Anouk Dev, Eldho Paul, Wa Cheung, Jim Koukounaras, Ashu Jhamb, Ben Marginson, Beng Ghee Lim, Paul Simkin, Adina Borsaru, James Burnes, Mark Goodwin, Vivek Ramachandra, Manfred Spanger, John Lubel, Paul Gow…

    Citation: BMC Cancer 2020 20:483

    Content type: Research article

    Published on:

  43. Prostate MRI has become a corner stone in diagnosis of prostate cancer (PC). Diffusion weighted imaging and the apparent diffusion coefficient (ADC) can be used to reflect tumor microstructure. The present ana...

    Authors: Hans-Jonas Meyer, Andreas Wienke and Alexey Surov

    Citation: BMC Cancer 2020 20:482

    Content type: Research article

    Published on:

  44. High-intensity ultrasound (HIUS) has been increasingly investigated as a possible tool in the treatment of multiple tumor entities. However, there is only little knowledge on the effect of HIUS on the peritone...

    Authors: Agata Mikolajczyk, Tanja Khosrawipour, Joanna Kulas, Pawel Migdal, Mohamed Arafkas, Jakub Nicpon and Veria Khosrawipour

    Citation: BMC Cancer 2020 20:481

    Content type: Research article

    Published on:

  45. The CYP19A1 gene, which encodes the enzyme responsible for androgen aromatization into estrogens, may play an important role in breast cancer aggressiveness. However, no study has evaluated CYP19A1 gene expressio...

    Authors: Maria da Conceição Barros-Oliveira, Danylo Rafhael Costa-Silva, Larysse Cardoso Campos-Verdes, Renato de Oliveira Pereira, Rozirene Araújo Silva, Paulo de Tarso Moura-Borges, Emerson Brandão Sousa, André Luiz Pinho-Sobral, Pedro Vitor Lopes-Costa, Alesse Ribeiro dos Santos, Ione Maria Ribeiro Soares-Lopes, Jackeline Lopes Viana, Mariella de Almeida Melo, Fidelis Manes Neto, Eid Gonçalves Coelho, Maria do Socorro Pires e Cruz…

    Citation: BMC Cancer 2020 20:480

    Content type: Research article

    Published on:

  46. Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asian...

    Authors: Hind El yacoubi, Mohamed Lemine Sow, Fouad Kettani, Lamia Gamra, Amina Mestari, Lamia Jabri, Ibrahim Elghissassi and Hassan Errihani

    Citation: BMC Cancer 2020 20:479

    Content type: Research article

    Published on:

  48. Oral cancer is a growing problem worldwide, with high incidence rates in South Asian countries. With increasing numbers of South Asian immigrants in developed countries, a possible rise in oral cancer cases is...

    Authors: Nidhi Saraswat, Rona Pillay, Bronwyn Everett and Ajesh George

    Citation: BMC Cancer 2020 20:477

    Content type: Research article

    Published on:

  49. Advanced cancer stage at diagnosis may explain high cancer mortality among patients with a severe psychiatric illness (SPI). Studies to date investigating advanced stage cancer at diagnosis as a potential expl...

    Authors: Alyson L. Mahar, Paul Kurdyak, Timothy P. Hanna, Natalie G. Coburn and Patti A. Groome

    Citation: BMC Cancer 2020 20:476

    Content type: Research article

    Published on:

  50. Pancreatic ductal adenocarcinoma is a devastating disease with poor outcome, generally characterized by an excessive stroma component. The purpose of this study was to develop a simple and reproducible in vitr...

    Authors: K. J. Norberg, X. Liu, C. Fernández Moro, C. Strell, S. Nania, M. Blümel, A. Balboni, B. Bozóky, R. L. Heuchel and J. M. Löhr

    Citation: BMC Cancer 2020 20:475

    Content type: Research article

    Published on:

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