P38 mitogen activated protein kinase is an intermediary signal transduction factor with context-specific roles in breast cancer. Recent mechanistic studies add to the growing consensus that P38 is a tumour sup...
Authors: Simon J. Johnston, Dena Ahmad, Mohammed A. Aleskandarany, Sasagu Kurozumi, Chris C. Nolan, Maria Diez-Rodriguez, Andrew R. Green and Emad A. Rakha
Remodeling of Ca2+ signaling is an important step in cancer progression, and altered expression of members of the Ca2+ signaling toolkit including the plasma membrane Ca2+ ATPases (PMCA proteins encoded by ATP2B ...
Authors: Karolina Varga, Anna Hollósi, Katalin Pászty, Luca Hegedűs, Gergely Szakács, József Tímár, Béla Papp, Ágnes Enyedi and Rita Padányi
Stereotactic ablative body radiotherapy (SABR) is a non-invasive alternative to surgery to control primary renal cell cancer (RCC) in patients that are medically inoperable or at high-risk of post-surgical dia...
Authors: Shankar Siva, Brent Chesson, Mathias Bressel, David Pryor, Braden Higgs, Hayley M. Reynolds, Nicholas Hardcastle, Rebecca Montgomery, Ben Vanneste, Vincent Khoo, Jeremy Ruben, Eddie Lau, Michael S. Hofman, Richard De Abreu Lourenco, Swetha Sridharan, Nicholas R. Brook…
Androgen deprivation therapy (ADT) is commonly used to treat prostate cancer. However, side effects of ADT often lead to reduced quality of life and physical function. Existing evidence demonstrates that exerc...
Authors: Shabbir M. H. Alibhai, Paul Ritvo, Daniel Santa Mina, Catherine Sabiston, Murray Krahn, George Tomlinson, Andrew Matthew, Himu Lukka, Padraig Warde, Sara Durbano, Meagan O’Neill and S. Nicole Culos-Reed
Territorial differences in the access to innovative anticancer drugs have been reported from many countries. The objectives of this study were to evaluate access to innovative treatments for metastatic lung ca...
Tumor suppressor gene p16 promoter hypermethylation has been widely studied in colorectal cancer (CRC), yet its clinicopathological significance remains controversial. The methylation alterations of other regions...
Authors: Xiaoxia Ye, Mingming Mo, Simin Xu, Qingjin Yang, Minhua Wu, Junjie Zhang, Bin Chen, Jian Li, Yu Zhong, Qionglin Huang and Chun Cai
How patients recover and resume everyday life after curative hepato-pancreato-biliary (HPB) surgery with intestinal reconstruction has, to our knowledge, not previously been investigated. We wanted to explore ...
Authors: Kristine Elberg Dengsø, Tine Tjørnhøj-Thomsen, Susanne Oksbjerg Dalton, Bo Marcel Christensen, Jens Hillingsø and Thordis Thomsen
Receptor activator of nuclear factor kappa-B (RANK)-signaling is involved in tumor growth and spread in experimental models. Binding of RANK ligand (RANKL) to RANK activates signaling, which is inhibited by os...
Authors: Danja Sarink, Helena Schock, Theron Johnson, Jenny Chang-Claude, Kim Overvad, Anja Olsen, Anne Tjønneland, Patrick Arveux, Agnès Fournier, Marina Kvaskoff, Heiner Boeing, Anna Karakatsani, Antonia Trichopoulou, Carlo La Vecchia, Giovanna Masala, Claudia Agnoli…
Colorectal cancer is a significant issue internationally, with over 1.3 million people diagnosed annually. Survival rates are increasing as treatments improve, although physical symptoms can persist despite er...
Authors: Claire O’Gorman, Jim Stack, Alan O’Ceilleachair, Suzanne Denieffe, Martina Gooney, Martina McKnight and Linda Sharp
MicroRNAs (miRNAs) are important regulators of cellular function and have been associated with both aging and cancer, but the impact of chemotherapy on age-related miRNAs has barely been studied.
Authors: Bruna Dalmasso, Sigrid Hatse, Barbara Brouwers, Annouschka Laenen, Lieze Berben, Cindy Kenis, Ann Smeets, Patrick Neven, Patrick Schöffski and Hans Wildiers
Peripheral monocyte count is an assessable parameter. Recently, evidence suggested an elevated preoperative monocyte counts predicting poor prognosis in malignancies. The aim of this study was to determine the...
Authors: Yang Hai, Nan Chen, Wenwen Wu, Zihuai Wang, Feng Lin, Chenglin Guo, Chengwu Liu, Weimin Li and Lunxu Liu
Shared decision-making (SDM) is recommended for men facing prostate cancer (PC) screening decisions. We synthesize the evidence on the comparative effectiveness of SDM with usual care.
Authors: Nahara Anani Martínez-González, Stefan Neuner-Jehle, Andreas Plate, Thomas Rosemann and Oliver Senn
The dismal prognosis of patients with glioblastoma (GBM) is attributed to a rare subset of cancer stem cells that display characteristics of tumor initiation, growth, and resistance to aggressive treatment inv...
Authors: Brian Tung, Ding Ma, Shuyan Wang, Olutobi Oyinlade, John Laterra, Mingyao Ying, Sheng-Qing Lv, Shuang Wei and Shuli Xia
Cancer survivors may be at increased risk of cardiovascular diseases, but little is known about whether prescribing guidelines for the primary prevention of cardiovascular disease are adequately implemented in...
Authors: Kendal Chidwick, Helen Strongman, Anthony Matthews, Susannah Stanway, Alexander R. Lyon, Liam Smeeth and Krishnan Bhaskaran
NDRG2 is identified as a tumor suppressor gene in many tumors, and functions in cell proliferation, differentiation and apoptosis. Recent data indicate that NDRG2 expression is up-regulated by TP53. Moreover, pro...
Authors: Yu-Qiong Yang, Tian Tian, Hua-Yuan Zhu, Jin-Hua Liang, Wei Wu, Jia-Zhu Wu, Yi Xia, Li Wang, Lei Fan, Jian-Yong Li and Wei Xu
Nanoparticle albumin-bound (nab)-paclitaxel has better efficacy, safety profiles, and no need to use prophylactic steroids compared with solvent-based paclitaxel. We performed a single arm, phase II study to e...
Authors: Yannan Zhao, Fangfang Lv, She Chen, Zhonghua Wang, Jian Zhang, Sheng Zhang, Jun Cao, Leiping Wang, Enying Cao, Biyun Wang and Xichun Hu
The Insulin-like growth factor (IGF) pathway plays a role in tumour development and progression. In vivo, IGF1 activity is regulated by the IGF binding proteins (IGFBPs). IGFBP4 inhibits the activity of IGF1 b...
Authors: Y. E. Smith, S. Toomey, S. Napoletano, G. Kirwan, C. Schadow, A. J. Chubb, J. H. Mikkelsen, C. Oxvig and J. H. Harmey
Merkel cell carcinoma (MCC) is a rare neuroendocrine malignancy of the skin characterized by high aggressiveness. Four main factors are implicated in its development: immunosuppression, ultraviolet radiation, ...
Authors: Daniele Lavacchi, Stefania Nobili, Marco Brugia, Agnese Paderi, Sara Fancelli, Enrico Caliman, Federica Vergoni and Enrico Mini
Compared with standard chemotherapy, epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are more effective in patients with advanced non-small-cell lung cancer (NSCLC) harboring EGFR mutat...
Authors: Naoto Aiko, Tsuneo Shimokawa, Kazuhito Miyazaki, Yuki Misumi, Yoko Agemi, Mari Ishii, Yukiko Nakamura, Takeharu Yamanaka and Hiroaki Okamoto
Metastasis is the main cause of death in patients with advanced stage colon cancer. Epithelial mesenchymal transition (EMT) plays an important role in invasion and metastasis. Actin-like 6A (ACTL6A) is vital f...
Renal impairment (RI) is a negative prognostic factor in Multiple Myeloma (MM) and affected patients are often excluded from autologous stem cell transplantation (ASCT). However, it remains unclear whether his...
Authors: Marlies Antlanger, Tobias Dust, Thomas Reiter, Alexandra Böhm, Wolfgang W. Lamm, Max Gornicec, Ella Willenbacher, David Nachbaur, Roman Weger, Werner Rabitsch, Susanne Rasoul-Rockenschaub, Nina Worel, Daniel Lechner, Hildegard Greinix, Felix Keil, Heinz Gisslinger…
Fear of cancer recurrence (FCR) has been shown to be higher in patients treated with external beam radiotherapy (RT) compared to those untreated. However, little is known about the dynamics of patient’s FCR du...
Authors: Y. Yang, J. Cameron, C. Bedi and G. Humphris
Nearly one third of patients undergoing neoadjuvant chemoradiotherapy (nCRT) for locally advanced esophageal cancer have a pathologic complete response (pCR) of the primary tumor upon histopathological evaluat...
Authors: A. S. Borggreve, S. Mook, M. Verheij, V. E. M. Mul, J. J. Bergman, A. Bartels-Rutten, L. C. ter Beek, R. G. H. Beets-Tan, R. J. Bennink, M. I. van Berge Henegouwen, L. A. A. Brosens, I. L. Defize, J. M. van Dieren, H. Dijkstra, R. van Hillegersberg, M. C. Hulshof…
The evaluation of cervical lymph nodes is very important for patients with papillary thyroid carcinoma (PTC). Conventional ultrasound is recommended to assess the status of cervical lymph nodes but the diagnos...
Authors: Wanying Chang, Lei Tang, Caiwei Lu, Min Wu and Man Chen
The incidence of ocular metastasis from lung cancer is reported to be 0.1–7%, with adenocarcinoma and small cell lung cancer accounting for the highest proportions of these cases. The majority of cases involve...
Authors: Ye Guo, Xu Wang, Jun Xiao, Yinghui Xu, Yangyang Cai, Chao Sun and Kewei Ma
Rigors are a significant adverse event during interleukin-2 (IL2) therapy for metastatic melanoma and renal cell carcinoma. Meperidine has been a mainstay for rigor prophylaxis but there is a paucity of data r...
Authors: Brian Khong, Benjamin O. Lawson, Junjie Ma, Cheryl McGovern, Joan K. Van Atta, Abhijit Ray and Hung T. Khong
The aim of this study was to determine the HPV positivity rate in patients with laryngeal cancer, and to determine the effect of HPV positivity on survival. An additional aim was to determine if patients with ...
Authors: Ozlem Onerci Celebi, Ebru Sener, Sefik Hosal, Mustafa Cengiz, Ibrahim Gullu and Gaye Guler Tezel
Sarcomas that arise from the scapula or periscapular soft tissues often require a total scapulectomy. This often implies a large complex tissue defect that needs adequate reconstruction of both bone and soft t...
Authors: Giovanni Beltrami, Gabriele Ristori, Guido Scoccianti, Angela Tamburini, Rodolfo Capanna, Domenico Campanacci and Marco Innocenti
Rituximab plus combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) is broadly accepted as standard for the treatment of diffuse large B-cell lymphoma (DLBCL). Neve...
Authors: Roland Christian Schelker, Wolfgang Herr, Albrecht Reichle and Martin Vogelhuber
Even though the post-operative outcome varies greatly among patients with nodal positive colon cancer (UICC stage III), personalized prediction of systemic disease recurrence is currently insufficient. We inve...
Authors: Andreas Sperlich, Alexander Balmert, Dietrich Doll, Sabine Bauer, Fabian Franke, Gisela Keller, Dirk Wilhelm, Anna Mur, Michael Respondek, Helmut Friess, Ulrich Nitsche and Klaus-Peter Janssen
Epidemiologists are beginning to employ metabolomics and lipidomics with archived blood from incident cases and controls to discover causes of cancer. Although several such studies have focused on colorectal c...
Authors: Kelsi Perttula, Courtney Schiffman, William M B Edmands, Lauren Petrick, Hasmik Grigoryan, Xiaoming Cai, Marc J Gunter, Alessio Naccarati, Silvia Polidoro, Sandrine Dudoit, Paolo Vineis and Stephen M Rappaport
The tumour microenvironment conferred by mesenchymal stem cells (MSCs) plays a key role in tumour development and progression. We previously determined that platelet-activating factor receptor (PAFR) was overe...
Authors: Tong Gao, Yi Yu, Qing Cong, Yisheng Wang, Mingming Sun, Liangqing Yao, Congjian Xu and Wei Jiang
Systemic inflammation has been implicated in cancer development and progression. This study examined the best cutoff value of erythrocyte sedimentation rate (ESR) in diffuse large B-cell lymphoma (DLBCL) patie...
Authors: Shuang Wu, Ye Zhou, Hai-Ying Hua, Yan Zhang, Wen-Yan Zhu, Zhi-Qing Wang, Jin Li, Hua-Qiang Gao, Xiao-Hong Wu, Ting-Xun Lu and Dong Hua
The imbalance between the action of the tissue inhibitors of matrix metalloproteinases (TIMPs) and the matrix metalloproteinases (MMPs) is one component of metastasis physiology. TIMP-1 overrides MMP-9 activit...
Authors: Renato F. Ivanovic, Nayara I. Viana, Denis R. Morais, Caio Moura, Iran A. Silva, Katia R. Leite, José Pontes-Junior, William C. Nahas, Miguel Srougi and Sabrina T. Reis
Ceritinib demonstrated a statistically significant effect on the progression-free survival versus chemotherapy in patients with advanced anaplastic lymphoma kinase (ALK) rearrangement in non-small cell lung ca...
Epithelioid hemangioendothelioma is an exceedingly rare sarcoma often occurring as an indolent angiocentric vascular tumor at various anatomic sites. Few reports have evaluated large case series of epithelioid...
The number of patients requesting autologous breast reconstruction (ABR) after mastectomy for breast cancer has increased over the past decades. However, concern has been expressed about the oncological safety...
Authors: Joachim Geers, Hans Wildiers, Katrien Van Calster, Annouschka Laenen, Giuseppe Floris, Marc Vandevoort, Gerd Fabre, Ines Nevelsteen and Ann Smeets
Sarcomas are rare, heterogeneous tumours affecting patients of any age. Previous surveys describe that sarcoma patients report a significantly worse experience than those with common cancers. Consequently, Sar...
Authors: Eugenie Younger, Olga Husson, Lindsey Bennister, Jeremy Whelan, Roger Wilson, Andy Roast, Robin L Jones and Winette TA van der Graaf
Home parenteral nutrition (HPN) can improve survival, quality of life, nutritional and functional status in cancer patients. Bioelectrical impedance analysis (BIA) is a non-invasive, validated method to assess...
Authors: Paolo Cotogni, Taira Monge, Maurizio Fadda and Antonella De Francesco
DNA methylation (DNAm) age was found to be an indicator for all-cause mortality, cancer incidence, and longevity, but no study has involved in the associations of DNAm age with the prognosis of breast cancer.
Authors: Jun-Ting Ren, Mei-Xia Wang, Yi Su, Lu-Ying Tang and Ze-Fang Ren
Application of dendritic cells (DC) for cancer immunotherapy involves tumor-associated immunogenic antigens for effective therapeutic strategies. The present study investigated whether DC co-cultured with auto...
Authors: Tao Yang, Wenjun Zhang, Li Wang, Chunyan Xiao, Li Wang, Yi Gong, Dehong Huang, Bingling Guo, Qiying Li, Ying Xiang and Yingyu Nan
The prognosis for pancreatic cancer remains poor despite diagnostic advances and treatments with new chemotherapeutic regimens. The five year survival rate remains below 3%. Consequently, there is an urgent ne...
Authors: Cindy Canivet, Sophie Gourgou-Bourgade, Bertrand Napoléon, Laurent Palazzo, Nicolas Flori, Pierre Guibert, Guillaume Piessen, Dominique Farges-Bancel, Jean-François Seitz, Eric Assenat, Véronique Vendrely, Stéphanie Truant, Geoffroy Vanbiervliet, Philippe Berthelémy, Stéphane Garcia, Anne Gomez-Brouchet…
Indirect evidence suggesting the immunosensitivity/immunogenicity of neuroblastoma is accumulating. The aims of this study were to investigate the immune landscape of neuroblastoma and to evaluate the in vivo ...
Authors: Chiara Camisaschi, Salvatore Lorenzo Renne, Valeria Beretta, Francesca Rini, Rosalin Dolores Spagnuolo, Alessandra Tuccitto, Marta Giorgia Podda, Giorgio Parmiani, Licia Rivoltini, Paola Collini, Chiara Castelli and Roberto Luksch
In ovarian cancer, the role of estrogen receptors (ERs), particularly of ERβ, being suggested as tumor suppressor in breast and prostate cancer, remains unclear. We examined the expression of nuclear and cytop...
Authors: Susanne Schüler-Toprak, Florian Weber, Maciej Skrzypczak, Olaf Ortmann and Oliver Treeck
Erlotinib is a drug used for the treatment of non-small cell lung cancer (NSCLC) and pancreatic cancer. Severe hepatotoxicity was observed in 4% to 31% of patients receiving erlotinib treatment prompting delay...
Authors: Min Kyoung Kim, Jeong Yee, Yoon Sook Cho, Hong Won Jang, Ji Min Han and Hye Sun Gwak
The impact of tumor size on prognosis for surgically treated patients with pancreatic ductal adenocarcinoma (PDAC) remains controversial. A systematic review and meta-analysis was performed to evaluate this is...
Authors: Debang Li, Bin Hu, Yanming Zhou, Tao Wan and Xiaoying Si
Sarcomas account for less than 1% of primary breast cancers, and breast angiosarcomas are responsible for only 0.05% of all breast malignancies. The male breast has the same potential for malignant transformat...
Authors: Benedito Borges da Silva, Walberto Monteiro Neiva Eulálio Filho, Pedro Vitor Lopes Costa, Rozirene Araújo Silva, Ariton Mendes Conde Junior, Diego Cipriano Chagas, Mariella de Almeida Melo, Fidelis Manes Neto, Cleciton Braga Tavares, Edilson Carvalho de Sousa Júnior, Eid Gonçalves Coelho, Viriato Campelo, Luis Henrique Gebrim and Raimundo Gerônimo da Silva Junior
Although peripheral blood-based parameters (PBBPs) are reported as prognostic indicators in patients with breast cancers, their utility has not been studied in human epidermal growth factor receptor 2 (HER2)-p...
The combination of gemcitabine and docetaxel (GT) has been demonstrated to be effective against various types of solid tumors, including sarcoma. However, the regimen has not been confirmed in large, well-desi...
