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  1. Cranial radiotherapy (cRT) can induce hormonal deficiencies as a consequence of significant doses to the hypothalamic-pituitary (HP) axis. In contrast to profound endocrinological follow-up data from survivors...

    Authors: P. Mehta, F. B. Fahlbusch, D. Rades, S. M. Schmid, J. Gebauer and S. Janssen

    Citation: BMC Cancer 2019 19:1213

    Content type: Research article

    Published on:

  2. As biomarkers, DNA methylation is used to detect colorectal cancer (CRC) and make assessment of CRC prognosis. The published findings showed the association between the methylation of SFRP1, SFRP2, and WIF1, loca...

    Authors: Xinyan Liu, Jinming Fu, Haoran Bi, Anqi Ge, Tingting Xia, Yupeng Liu, Hongru Sun, Dapeng Li and Yashuang Zhao

    Citation: BMC Cancer 2019 19:1212

    Content type: Research article

    Published on:

  3. Increasing evidence indicates an etiological role of human papillomavirus (HPV) in head and neck cancers, particularly oropharyngeal squamous cell carcinoma (OPSCC). However, the association between HPV and ot...

    Authors: Siaw Shi Boon, Zigui Chen, Jintao Li, Karen Y. C. Lee, Liuyang Cai, Rugang Zhong and Paul K. S. Chan

    Citation: BMC Cancer 2019 19:1211

    Content type: Research article

    Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:1255

  4. It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver oligometastases (CRCLOM) remains unclear.

    Authors: Qiaoqi Sui, Jian Zheng, Dingxin Liu, Jianhong Peng, Qingjian Ou, Jinghua Tang, Yuan Li, Lingheng Kong, Wu Jiang, Binyi Xiao, Xue Chao, Zhizhong Pan, Huizhong Zhang and Pei-Rong Ding

    Citation: BMC Cancer 2019 19:1210

    Content type: Research article

    Published on:

  5. Treatment with radioactive iodine is effective for many patients with progressive, locally advanced or metastatic, differentiated thyroid cancer. However, some patients become refractory to treatment. These ty...

    Authors: Nigel Fleeman, Rachel Houten, Marty Chaplin, Sophie Beale, Angela Boland, Yenal Dundar, Janette Greenhalgh, Rui Duarte and Aditya Shenoy

    Citation: BMC Cancer 2019 19:1209

    Content type: Research article

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  6. Radical radiotherapy is the standard treatment for patients with locally advanced cervix uteri carcinoma (FIGO stage IB2–IVA). Worldwide, incidence and mortality rates vary among regions because of differences...

    Authors: Alparslan Serarslan, Bilge Gursel, Deniz Meydan and Nilgun Ozbek Okumus

    Citation: BMC Cancer 2019 19:1208

    Content type: Research article

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  7. We aimed to estimate the stage-specific impact of lymph node dissection (LND) on survival for upper urinary tract urothelial carcinoma (UTUC) patients treated with nephroureterectomy (NU).

    Authors: Ting-Shuai Zhai, Liang Jin, Zhen Zhou, Xiang Liu, Huan Liu, Wei Chen, Jing-Yi Lu, Xu-Dong Yao, Li-Ming Feng and Lin Ye

    Citation: BMC Cancer 2019 19:1207

    Content type: Research article

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  8. Stereotactic ablative radiotherapy (SABR) has become an established treatment option for medically-inoperable early-stage (Stage I-IIA) non-small cell lung cancer (ES-NSCLC). SABR is able to obtain high rates ...

    Authors: David A. Palma, Hanbo Chen, Houda Bahig, Stewart Gaede, Stephen Harrow, Joanna M. Laba, X. Melody Qu, George B. Rodrigues, Brian P. Yaremko, Edward Yu, Alexander V. Louie, Inderdeep Dhaliwal and Christopher J. Ryerson

    Citation: BMC Cancer 2019 19:1206

    Content type: Study protocol

    Published on:

  9. Cervical cancer is the second cause leading of malignancy-related death among Mexican women. The present study determined the population-based prevalence of high risk Human Papillomavirus (HR-HPV) infection an...

    Authors: K. Torres-Poveda, I. Ruiz-Fraga, V. Madrid-Marina, M. Chavez and V. Richardson

    Citation: BMC Cancer 2019 19:1205

    Content type: Research article

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  10. Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammato...

    Authors: Takumi Kishimoto, Nobukazu Fujimoto, Takeshi Ebara, Toyonori Omori, Tetsuya Oguri, Akio Niimi, Takako Yokoyama, Munehiro Kato, Ikuji Usami, Masayuki Nishio, Kosho Yoshikawa, Takeshi Tokuyama, Mouka Tamura, Yoshifumi Yokoyama, Ken Tsuboi, Yoichi Matsuo…

    Citation: BMC Cancer 2019 19:1204

    Content type: Research article

    Published on:

  11. Transcription factors forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) have been reported to play important roles in various cancers. However, their role in epithelial ovarian cancer (EOC) has not been ...

    Authors: Gwan Hee Han, Doo Byung Chay, Sanghee Nam, Hanbyoul Cho, Joon-Yong Chung and Jae-Hoon Kim

    Citation: BMC Cancer 2019 19:1202

    Content type: Research article

    Published on:

  12. In patients diagnosed with ductal carcinoma in situ (DCIS) with needle biopsy before surgery, invasive component (IC) is often found in the postoperative tissue, which results in altered post-surgical care. Ho...

    Authors: Kwan Ho Lee, Jeong Woo Han, Eun Young Kim, Ji Sup Yun, Yong Lai Park and Chan Heun Park

    Citation: BMC Cancer 2019 19:1201

    Content type: Research article

    Published on:

  13. On the basis of some significant clinical parameters, we had an intent to establish nomograms for estimating the prognosis of patients with squamous cell carcinoma of the urinary bladder (SCCB), including over...

    Authors: Guanghao Zhang, Zhiwei Li, Daoqing Song and Zhiqing Fang

    Citation: BMC Cancer 2019 19:1200

    Content type: Research article

    Published on:

  14. Hormone replacement therapy (HRT) use has shown to be associated with a reduced risk of colorectal cancer, however, its impact on survival among women with colorectal cancer remains uncertain. This meta-analys...

    Authors: Yeu-Chai Jang, Hsi-Lan Huang and Chi Yan Leung

    Citation: BMC Cancer 2019 19:1199

    Content type: Research article

    Published on:

  15. Māori, Pacific and Asian women in New Zealand have lower cervical-cancer screening rates than European women, and there are persistent inequities in cervical cancer outcomes for Māori and Pacific women. Innova...

    Authors: Naomi Brewer, Karen Bartholomew, Anna Maxwell, Jane Grant, Helen Wihongi, Collette Bromhead, Nina Scott, Sue Crengle, Chris Cunningham, Jeroen Douwes and John D. Potter

    Citation: BMC Cancer 2019 19:1198

    Content type: Study protocol

    Published on:

  16. Glioblastoma multiform (GBM), a malignant brain tumour, has a very often poor prognosis. The therapeutic approach is represented by surgery followed by radiotherapy and chemotherapy. Hypoxia is a factor that c...

    Authors: Vincenzo Gangemi, Chiara Mignogna, Giusy Guzzi, Angelo Lavano, Salvatore Bongarzone, Giuseppe Lucio Cascini and Umberto Sabatini

    Citation: BMC Cancer 2019 19:1197

    Content type: Case report

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  17. NF1(Neurofibromatosis type 1) is an autosomal dominant genetic disorder. Patients with NF1 have an increased risk of developing benign or malignant tumours, such as gastrointestinal stromal tumours (GISTs). Ho...

    Authors: Liang Shang, Zhen Fang, Jin Liu, Fengying Du, Haiyan Jing, Yali Xu, Kangdi Dong, Xiaoman Zhang, Hao Wu, Changqing Jing and Leping Li

    Citation: BMC Cancer 2019 19:1196

    Content type: Case report

    Published on:

  18. To discover biomarker panels that could distinguish cancers (BC and RCC) from healthy controls (HCs) and bladder cancers (BC) from renal cell carcinoma (RCC), regardless of whether the patients have haematuria...

    Authors: Zhan Wang, Xiaoyan Liu, Xiang Liu, Haidan Sun, Zhengguang Guo, Guoyang Zheng, Yushi Zhang and Wei Sun

    Citation: BMC Cancer 2019 19:1195

    Content type: Research article

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  19. Brain metastasis (BM) is a rare event in ovarian cancer patients. The current prognostic scores that have been used for other tumors do not account for specific characteristics of ovarian cancer, such as plati...

    Authors: Alexandre André Balieiro Anastácio da Costa, Elizabeth Santana dos Santos, Deborah Porto Cotrim, Natasha Carvalho Pandolfi, Marcelle Goldner Cesca, Henrique Mantoan, Solange Moraes Sanches, Adriana Regina Gonçalves Ribeiro, Louise de Brot, Graziele Bonvolim, Paulo Issamu Sanematsu, Ronaldo Pereira de Souza, Joyce Maria Lisboa Maya, Fabrício de Souza Castro, João Paulo da Nogueira Silveira Lima, Michael Jenwel Chen…

    Citation: BMC Cancer 2019 19:1194

    Content type: Research article

    Published on:

  20. Immune checkpoint inhibitors (ICIs) have achieved unprecedented success in cancer treatment over the past decade. The application of ICIs hasled to the discovery of various types of immune-related adverse even...

    Authors: Yuan Liu, Zhi Liu, Xuejun Zeng, Chunmei Bai, Lin Chen, Songbai Lin and Xinlun Tian

    Citation: BMC Cancer 2019 19:1193

    Content type: Case report

    Published on:

  21. Hepatic stellate cells (HSCs) have a key role in fibrogenesis and in the filtrates of the hepatocellular carcinoma (HCC) stroma, in which they are remodeled and play a critical role in HCC progression. However...

    Authors: Xia Liao, Yang Bu, Fan Chang, Fengan Jia, Ge Song, Xuelian Xiao, Mei Zhang, Pengbo Ning and Qingan Jia

    Citation: BMC Cancer 2019 19:1192

    Content type: Research article

    Published on:

  22. Cholangiocarcinoma is a rapidly fatal cancer entity with a median survival of less than one year. In contrast to many other malignancies, no substantial therapeutic breakthrough has been made in the past few d...

    Authors: Thomas Albrecht, Melina Rausch, Stephanie Rössler, Michael Albrecht, Jana Dorothea Braun, Veronika Geissler, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil-Warth, Gunhild Mechtersheimer, Marcus Renner, Christian Rupp, Karl Heinz Weiss, Elena Busch, Bruno Köhler, Christoph Springfeld…

    Citation: BMC Cancer 2019 19:1191

    Content type: Research article

    Published on:

  23. Hepatocellular carcinoma (HCC) is an aggressive solid tumor. HCC occurred at younger and elder ages were considered driven by different oncogenic mechanisms, and they demonstrated distinct clinical courses.

    Authors: Puo-Hsien Le, Chia-Jung Kuo, Yi-Chung Hsieh, Tsung-Hsing Chen, Chih-Lang Lin, Chau-Ting Yeh and Kung-Hao Liang

    Citation: BMC Cancer 2019 19:1190

    Content type: Research article

    Published on:

  24. Utilization of RNA sequencing methods to measure gene expression from archival formalin-fixed paraffin-embedded (FFPE) tumor samples in translational research and clinical trials requires reliable interpretati...

    Authors: Michal Marczyk, Chunxiao Fu, Rosanna Lau, Lili Du, Alexander J. Trevarton, Bruno V. Sinn, Rebekah E. Gould, Lajos Pusztai, Christos Hatzis and W. Fraser Symmans

    Citation: BMC Cancer 2019 19:1189

    Content type: Research article

    Published on:

  25. An extremely rare condition, radiation-induced angiosarcoma is characterized by a poor prognosis, high recurrence rate and lack of effective treatment. Herein, we present a case report of a 48-year-old female ...

    Authors: Jieshan Guan, Zhijie Luo, Zhiwei Xiao, Yubin Xie and Lizhu Lin

    Citation: BMC Cancer 2019 19:1188

    Content type: Case report

    Published on:

  26. Precise staging is indispensable to select the appropriate treatment strategy for gastric cancer (GC); however, the diagnostic accuracy of conventional modalities needs to be improved. This study investigated ...

    Authors: Toshiyuki Kosuga, Tomoki Konishi, Takeshi Kubota, Katsutoshi Shoda, Hirotaka Konishi, Atsushi Shiozaki, Kazuma Okamoto, Hitoshi Fujiwara, Michihiro Kudou, Tomohiro Arita, Ryo Morimura, Yasutoshi Murayama, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi and Eigo Otsuji

    Citation: BMC Cancer 2019 19:1187

    Content type: Research article

    Published on:

  27. Currently, clinical studies on the prognosis of prostate cancer (PC) taking aspirin were developing, but the precise mechanism of aspirin on tumor cells was still unclear. In addition, the conclusion that aspi...

    Authors: Jiatong Zhou, Shuai Xia, Tao Li and Ranlu Liu

    Citation: BMC Cancer 2019 19:1186

    Content type: Research article

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  28. Several multicenter randomized controlled trials comparing laparoscopy and conventional open surgery for colon cancer have demonstrated that laparoscopic approach achieved the same oncological results while im...

    Authors: Gilles Manceau, Antoine Brouquet, Pascal Chaibi, Guillaume Passot, Olivier Bouché, Murielle Mathonnet, Jean-Marc Regimbeau, Rea Lo Dico, Jérémie H. Lefèvre, Frédérique Peschaud, Olivier Facy, Enrico Volpin, Elie Chouillard, Laura Beyert-Berjot, Marc Verny, Mehdi Karoui…

    Citation: BMC Cancer 2019 19:1185

    Content type: Study protocol

    Published on:

  29. The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-...

    Authors: Tone Hoel Lende, Marie Austdal, Tone Frost Bathen, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Nina G. Egeland, Siri Lunde, Lars A. Akslen, Kristin Jonsdottir, Emiel A. M. Janssen, Håvard Søiland and Jan P. A. Baak

    Citation: BMC Cancer 2019 19:1183

    Content type: Research article

    Published on:

  30. Excess body weight and sub-optimal lifestyle are modifiable causes of breast cancer and other diseases. There is little evidence that behaviour change is possible within screening programmes and whether this i...

    Authors: Michelle Harvie, Mary Pegington, David French, Grace Cooper, Sarah McDiarmid, Anthony Howell, Louise Donnelly, Helen Ruane, Katharine Sellers, Philip Foden and D. Gareth Evans

    Citation: BMC Cancer 2019 19:1089

    Content type: Research article

    Published on:

  31. To determine safety and efficacy of radiofrequency ablation (RFA) for local treatment of lung metastases of renal cell carcinoma (RCC), sequenced or combined with systemic treatments.

    Authors: Alexis Gonnet, Laura Salabert, Guilhem Roubaud, Vittorio Catena, Véronique Brouste, Xavier Buy, Marine Gross Goupil, Alain Ravaud and Jean Palussière

    Citation: BMC Cancer 2019 19:1182

    Content type: Research article

    Published on:

  32. While colorectal cancer (CRC) patients with localized disease have a favorable prognosis, the five-year-survival rate in patients with distant spread is still below 15%. Hence, a detailed understanding of the ...

    Authors: Sarah Weber, Sebastian E. Koschade, Christopher M. Hoffmann, Taronish D. Dubash, Klara M. Giessler, Sebastian M. Dieter, Friederike Herbst, Hanno Glimm and Claudia R. Ball

    Citation: BMC Cancer 2019 19:1181

    Content type: Research article

    Published on:

  33. Interleukin-6 (IL-6) is commonly highly secreted in the breast cancer (BrCA) microenvironment and implicated in disease development. In this study, we aimed to determine the role of the IL-6/pSTAT3/HIC1 axis i...

    Authors: Xueqing Sun, Qing Qu, Yimin Lao, Mi Zhang, Xiaoling Yin, Huiqin Zhu, Ying Wang, Jie Yang, Jing Yi and Mingang Hao

    Citation: BMC Cancer 2019 19:1180

    Content type: Research article

    Published on:

  34. Some historic breakthroughs have been made in immunotherapy of advanced cancer. However, there is still little research on immunotherapy in prostate cancer. We explored the relationship between immune cell inf...

    Authors: Xin Rui, Siliang Shao, Li Wang and Jiangyong Leng

    Citation: BMC Cancer 2019 19:1179

    Content type: Research article

    Published on:

  35. Previous studies have suggested that lymphoma survivors commonly display altered Health-Related Quality of Life (HRQoL). Because these were predominantly cross-sectional studies, the dynamic of events as well ...

    Authors: Gisèle Compaci, Cécile Conte, Lucie Oberic, Loïc Ysebaert, Guy Laurent and Fabien Despas

    Citation: BMC Cancer 2019 19:1178

    Content type: Research article

    Published on:

  36. Following publication of the original article [1], the authors reported an omission in the affiliations.

    Authors: Shereen El-Mashed, Tracey R. O’Donovan, Elaine W. Kay, Ayat R. Abdallah, Mary-Clare Cathcart, Jacintha O’Sullivan, Anthony O’Grady, John Reynolds, Seamus O’Reilly, Gerald C. O’Sullivan and Sharon L. McKenna

    Citation: BMC Cancer 2019 19:1177

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2015 15:582

  37. Deciphering the meaning of the human DNA is an outstanding goal which would revolutionize medicine and our way for treating diseases. In recent years, non-coding RNAs have attracted much attention and shown to...

    Authors: Johannes Smolander, Alexey Stupnikov, Galina Glazko, Matthias Dehmer and Frank Emmert-Streib

    Citation: BMC Cancer 2019 19:1176

    Content type: Research Article

    Published on:

  38. Pancreatic ductal adenocarcinoma (PDAC) is considered as one of the most aggressive cancers lacking efficient early detection biomarkers. Circulating miRNAs are now being considered to have potency to be used ...

    Authors: Bishnupriya Chhatriya, Moumita Mukherjee, Sukanta Ray, Piyali Sarkar, Shatakshee Chatterjee, Debashis Nath, Kshaunish Das and Srikanta Goswami

    Citation: BMC Cancer 2019 19:1175

    Content type: Research article

    Published on:

  39. The prognoses of head and neck squamous cell carcinoma (HNSCC) and esophageal squamous cell carcinoma (ESCC) are poor, especially when both tumors occur at the same time. We examined the clonal relatedness of ...

    Authors: Somkiat Sunpaweravong, Sacarin Bunbanjerdsuk, Tanjitti Pongrujikorn, Chaiwat Naktang, Patrapim Sunpaweravong, Anupong Nitiruangjaras, Tanadech Dechaphankul and Natini Jinawath

    Citation: BMC Cancer 2019 19:1174

    Content type: Research article

    Published on:

  40. Locally advanced breast cancer often undergoes neoadjuvant chemotherapy (NAC), which allows in vivo evaluation of the therapeutic response. The determination of the pathological complete response (pCR) is one ...

    Authors: Wilson Eduardo Furlan Matos Alves, Murilo Bonatelli, Rozany Dufloth, Lígia Maria Kerr, Guilherme Freire Angotti Carrara, Ricardo Filipe Alves da Costa, Cristovam Scapulatempo-Neto, Daniel Tiezzi, René Aloísio da Costa Vieira and Céline Pinheiro

    Citation: BMC Cancer 2019 19:1173

    Content type: Research article

    Published on:

  41. In pediatric sarcomas, outcomes of established therapies still remain poor, especially due to high-grade resistances to chemotherapeutic compounds. Taking novel biological approaches into account, virotherapy ...

    Authors: Chihab Klose, Susanne Berchtold, Marina Schmidt, Julia Beil, Irina Smirnow, Sascha Venturelli, Markus Burkard, Rupert Handgretinger and Ulrich M. Lauer

    Citation: BMC Cancer 2019 19:1172

    Content type: Research article

    Published on:

  42. Luminal B cancers show much worse outcomes compared to luminal A. This present study aims to screen key lncRNAs and mRNAs correlated with luminal-B breast cancer.

    Authors: Cheng-Liang Yuan, Xiang-Mei Jiang, Ying Yi, Jian-Fei E, Nai-Dan Zhang, Xue Luo, Ning Zou, Wei Wei and Ying-Ying Liu

    Citation: BMC Cancer 2019 19:1171

    Content type: Research article

    Published on:

  43. Cisplatin is a potent chemotherapeutic agent used to treat a variety of solid tumors. One of the major side effects of cisplatin is dose-limiting nephrotoxicity. We recently demonstrated that the renal uptake ...

    Authors: Satoshi Shoji, Michihiro Hosojima, Hideyuki Kabasawa, Rie Kondo, Satoru Miura, Satoshi Watanabe, Nobumasa Aoki, Ryohei Kaseda, Shoji Kuwahara, Naohito Tanabe, Yoshiaki Hirayama, Ichiei Narita, Toshiaki Kikuchi, Hiroshi Kagamu and Akihiko Saito

    Citation: BMC Cancer 2019 19:1170

    Content type: Research article

    Published on:

  44. Urokinase plasminogen activator (uPA) is an extracellular matrix-degrading protease that is involved in the invasiveness and progression of cancer. There is good evidence that uPA expression is a clinically re...

    Authors: Ming-Chao Tsai, Yi-Hao Yen, Kuo-Chin Chang, Chao-Hung Hung, Chien-Hung Chen, Ming-Tsung Lin and Tsung-Hui Hu

    Citation: BMC Cancer 2019 19:1169

    Content type: Research article

    Published on:

  45. Adult Ewing sarcoma (ES) is a rare disease, the optimal treatment model is unknown. This study aimed to retrospectively analyze treatment-related prognostic factors of nonspinal ES in Chinese adults.

    Authors: Jianjun Zhang, Yujing Huang, Yuanjue Sun, Aina He, Yan Zhou, Haiyan Hu, Yang Yao and Zan Shen

    Citation: BMC Cancer 2019 19:1168

    Content type: Research article

    Published on:

  46. Circulating tumor cells (CTCs) are associated with breast cancer prognosis. Research is limited regarding the role of circulating cancer stem-like cells (cCSCs) considering the treatment response and survival ...

    Authors: Chun-Hui Lee, Jason Chia-Hsun Hsieh, Tyler Min-Hsien Wu, Ting-Shiuan Yeh, Hung-Ming Wang, Yung-Chan Lin, Jen-Shi Chen, Chia-Lin Lee, Wen-Kuan Huang, Tsung-Min Hung, Tzu-Tsen Yen, Sheng-Chieh Chan, Wen-Chi Chou, Feng-Che Kuan, Ching-Chih Hu and Pei-Hung Chang

    Citation: BMC Cancer 2019 19:1167

    Content type: Research article

    Published on:

  47. Lung cancer (LC) is one of the leading causes of death worldwide, which highlights the urgent need for better therapies. Peroxisome proliferator-activated nuclear receptor alpha (PPARα), known as a key nuclear...

    Authors: Lujin Wu, Wei Wang, Meiyan Dai, Huihui Li, Chen Chen and Daowen Wang

    Citation: BMC Cancer 2019 19:1166

    Content type: Research article

    Published on:

  48. Following publication of the original article [1], the authors reported the following error is the article

    Authors: Shuangmei Ye, Xing Hao, Ting Zhou, Mingfu Wu, Juncheng Wei, Yongjun Wang, Li Zhou, Xuefeng Jiang, Li Ji, Yin Chen, Lanying You, Yiqun Zhang, Gang Xu, Jianfeng Zhou, Ding Ma and Shixuan Wang

    Citation: BMC Cancer 2019 19:1164

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2010 10:611

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