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  1. Terminal differentiation-induced ncRNA (TINCR) plays an essential role in epidermal differentiation and is involved in the development of various cancers.

    Authors: Guoqing He, Rui Pang, Jihua Han, Jinliang Jia, Zhaoming Ding, Wen Bi, Jiawei Yu, Lili Chen, Jiewu Zhang and Yanan Sun

    Citation: BMC Cancer 2021 21:753

    Content type: Research article

    Published on:

  2. Advanced stage marginal zone lymphoma (MZL) is an incurable indolent B-cell lymphoma, for which a wide variety of treatments ranging from single agent rituximab to more dose intense immunochemotherapy exists. ...

    Authors: Alexander Grunenberg, Lisa M. Kaiser, Stephanie Woelfle, Birgit Schmelzle, Andreas Viardot, Peter Möller, Thomas F. E. Barth, Rainer Muche, Jens Dreyhaupt, Markus Raderer, Barbara Kiesewetter and Christian Buske

    Citation: BMC Cancer 2021 21:749

    Content type: Study protocol

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  3. Increased bone turnover is frequently observed in advanced cancer and predominantly related to bone metastases or therapy. Cachexia represents an important cause of morbidity and mortality in cancer patients. ...

    Authors: Hannes Zwickl, Elisabeth Zwickl-Traxler, Alexander Haushofer, Josef Seier, Klaus Podar, Michael Weber, Klaus Hackner, Nico Jacobi, Martin Pecherstorfer and Sonia Vallet

    Citation: BMC Cancer 2021 21:744

    Content type: Research

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  4. Availability of potent anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKI) has pushed the median survival of ALK+ non-smallcell lung cancer (NSCLC) patients to over five years. In particular, second...

    Authors: Petros Christopoulos, Farastuk Bozorgmehr, Lena Brückner, Inn Chung, Johannes Krisam, Marc A. Schneider, Albrecht Stenzinger, Regina Eickhoff, Daniel W. Mueller and Michael Thomas

    Citation: BMC Cancer 2021 21:743

    Content type: Study protocol

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  5. Carnitine is related to malaise, and cisplatin is associated with decreased carnitine. The purpose of this study was to elucidate the effects of one course of induction chemotherapy (IC) for head and neck canc...

    Authors: Tatsuya Ito, Kiyoaki Tsukahara, Hiroki Sato, Akira Shimizu and Isaku Okamoto

    Citation: BMC Cancer 2021 21:742

    Content type: Research

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  6. From patient-reported surveys and individual interviews by health care providers, we attempted to identify the significant factors related to the improvement of distress and fatigue for cancer survivors by tex...

    Authors: Kyungmi Yang, Jina Kim, Mison Chun, Mi Sun Ahn, Eunae Chon, Jinju Park and Mijin Jung

    Citation: BMC Cancer 2021 21:741

    Content type: Research article

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  7. NUT carcinoma (NC), previously known as NUT midline carcinoma, is a rare and very aggressive cancer that occurs in both children and adults. NC is largely chemoresistant, with an overall survival of less than ...

    Authors: Tina Carter, Maxine Crook, Ashleigh Murch, Alex H. Beesley, Nick de Klerk, Adrian Charles and Ursula R. Kees

    Citation: BMC Cancer 2021 21:740

    Content type: Research article

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  8. The health burden of breast cancer is rising in China. The effect of informed diagnosis on long-term survival is not fully understood. This retrospective cohort study aims to explore the association between ea...

    Authors: Chen He, Wen Xi Zhu, Yunxiang Tang, Yonghai Bai, Zheng Luo, Jinfang Xu, Hao Wang, Shuyu Xu, Jingzhou Xu, Lei Xiao, Ruike Zhang, Yajing Wang, Jing Du, Yujia Huang, Xiaopan Li and Tong Su

    Citation: BMC Cancer 2021 21:739

    Content type: Research article

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  9. To investigate the efficacy and safety of interval debulking surgery (IDS) combined with dense hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin in Chinese patients with FIGO stage III serous ep...

    Authors: Xiaoli He, Li Wei, Rui Li, Shuang Jing, Linlin Jia, Danwei Ji, Yali Li, Yue Wang and Yongxia Zhu

    Citation: BMC Cancer 2021 21:738

    Content type: Research article

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  10. Tryptophan 2,3-dioxygenase (TDO2) is the primary enzyme catabolizing tryptophan. Several lines of evidence revealed that overexpression of TDO2 is involved in anoikis resistance, spheroid formation, proliferat...

    Authors: Quoc Thang Pham, Daiki Taniyama, Yohei Sekino, Shintaro Akabane, Takashi Babasaki, Go Kobayashi, Naoya Sakamoto, Kazuhiro Sentani, Naohide Oue and Wataru Yasui

    Citation: BMC Cancer 2021 21:737

    Content type: Research

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  11. The Oncotype DX 21-gene Recurrence Score is predictive of adjuvant chemotherapy benefit for women with early-stage, estrogen receptor (ER)-positive, HER2-negative breast cancer. In premenopausal women, fluctua...

    Authors: Sarah M. Bernhardt, Pallave Dasari, Danielle J. Glynn, Lucy Woolford, Lachlan M. Moldenhauer, David Walsh, Amanda R. Townsend, Timothy J. Price and Wendy V. Ingman

    Citation: BMC Cancer 2021 21:736

    Content type: Research

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  12. Ductal carcinoma in situ (DCIS) patients are usually diagnosed through cancer screening programs, suggesting a healthy user effect. In this population-based cohort, we assessed the risk of cardiovascular event...

    Authors: Tae-Kyung Yoo, Sang Hyun Park, Kyung Do Han and Byung Joo Chae

    Citation: BMC Cancer 2021 21:735

    Content type: Research

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  13. Tracheobronchial adenoid cystic carcinoma (TACC) is a rare tumour. About one-third of patients miss their chance of surgery or complete resection as it is mostly detected in the advanced stage; hence, photon r...

    Authors: Jian Chen, Jingfang Mao, Ningyi Ma, Kai-Liang Wu, Jiade Lu and Guo-Liang Jiang

    Citation: BMC Cancer 2021 21:734

    Content type: Research

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  14. The more selective second-generation BTK inhibitors (BTKi) Acalabrutinib and Zanubrutinib and the first-generation BTKi Ibrutinib are highlighted by their clinical effectiveness in mantle cell lymphoma (MCL), ...

    Authors: Zhuojun Liu, Jia Liu, Tianming Zhang, Lin Li, Shuo Zhang, Hao Jia, Yuanshi Xia, Mingxia Shi, Jing Zhang, Shuhua Yue, Xiaofang Chen and Jian Yu

    Citation: BMC Cancer 2021 21:732

    Content type: Research article

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  15. A primary pulmonary invasive mucinous adenocarcinoma (IMA) is a rare subtype of invasive adenocarcinoma of the lung. The prognosis of advanced IMA depending on chemotherapy regimen has not been fully investiga...

    Authors: Yoon Jung Jang, Dong-gon Hyun, Chang-Min Choi, Dae Ho Lee, Sang-We Kim, Shinkyo Yoon, Woo Sung Kim, Wonjun Ji and Jae Cheol Lee

    Citation: BMC Cancer 2021 21:731

    Content type: Research article

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  16. Patients with multiple myeloma (MM) remain at an increased risk of infection due to the disease process, as well as the ensuing treatments.

    Authors: Nicole Balmaceda, Muhammad Aziz, Viveksandeep Thoguluva Chandrasekar, Brian McClune, Suman Kambhampati, Leyla Shune, Al-Ola Abdallah, Faiz Anwer, Aneela Majeed, Muzaffar Qazilbash, Siddhartha Ganguly, Joseph McGuirk and Ghulam Rehman Mohyuddin

    Citation: BMC Cancer 2021 21:730

    Content type: Research

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  17. The tumour-stroma ratio (TSR) is recognized as a practical prognostic factor in colorectal cancer. However, TSR assessment generally utilizes surgical specimens. This study aims to investigate whether the TSR ...

    Authors: Yanting Liang, Yaxi Zhu, Huan Lin, Shenyan Zhang, Suyun Li, Yanqi Huang, Chen Liu, Jinrong Qu, Changhong Liang, Ke Zhao, Zhenhui Li and Zaiyi Liu

    Citation: BMC Cancer 2021 21:729

    Content type: Research

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  18. It has been demonstrated that postmastectomy radiation therapy (PMRT) was beneficial for breast cancer patients who are axillary lymph node-positive. However, the effectiveness of radiotherapy in pathological ...

    Authors: Ke Wang, Xiaoyan Jin, Weilan Wang, Xiuyan Yu and Jian Huang

    Citation: BMC Cancer 2021 21:728

    Content type: Research

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  19. To analyze trends in cancer incidence and mortality (France, 1990–2018), with a focus on men-women disparities.

    Authors: G. Defossez, Z. Uhry, P. Delafosse, E. Dantony, T. d’Almeida, S. Plouvier, N. Bossard, A. M. Bouvier, F. Molinié, A. S. Woronoff, M. Colonna, P. Grosclaude, L. Remontet and A. Monnereau

    Citation: BMC Cancer 2021 21:726

    Content type: Research

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  20. Surgery is still the mainstay of radical treatment for resectable esophageal cancer (EC). It is apparent that the presence or spread of lymph node metastasis (LNM) is a powerful prognostic factor in patients w...

    Authors: Yutaka Miyawaki, Hiroshi Sato, Shuichiro Oya, Hirofumi Sugita, Yasumitsu Hirano, Shinichi Sakuramoto, Kojun Okamotom, Shigeki Yamaguchim and Isamu Koyama

    Citation: BMC Cancer 2021 21:725

    Content type: Research article

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  21. Cancer registries usually assess data of conventional treatments and/or patient survival. Beyond that, little is known about the influence of other predictors of treatment response related to the use of comple...

    Authors: Heidemarie Haller, Petra Voiß, Holger Cramer, Anna Paul, Mattea Reinisch, Sebastian Appelbaum, Gustav Dobos, Georg Sauer, Sherko Kümmel and Thomas Ostermann

    Citation: BMC Cancer 2021 21:724

    Content type: Study protocol

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  22. Tyrosine protein tyrosine kinase binding protein (TYROBP) binds non-covalently to activated receptors on the surface of various immune cells, and mediates signal transduction and cellular activation. It is dys...

    Authors: Jiajie Lu, Yuecheng Peng, Rihong Huang, Zejia Feng, Yongyang Fan, Haojian Wang, Zhaorong Zeng, Yunxiang Ji, Yezhong Wang and Zhaotao Wang

    Citation: BMC Cancer 2021 21:723

    Content type: Research

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  23. Most NSCLCs metastasised out of the lungs at the time of diagnosis and cannot be surgically removed . Cytotoxic chemotherapy drugs have become the main treatment in recent decades, especially in patients with ...

    Authors: Qing Xia, Guojie Chen, Yanbei Ren, Tiansheng Zheng, Changxing Shen, Ming Li, Xiangyun Chen, Hong Zhai, Zhuang Li, Jianfang Xu, Aiqin Gu, Meiling Jin and Lihong Fan

    Citation: BMC Cancer 2021 21:721

    Content type: Study protocol

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  24. The aim of this study was to identify sources of variability including patient gender and body surface area (BSA) in pharmacokinetic (PK) exposure for high-dose methotrexate (MTX) continuous infusion in a larg...

    Authors: Usman Arshad, Max Taubert, Tamina Seeger-Nukpezah, Sami Ullah, Kirsten C. Spindeldreier, Ulrich Jaehde, Michael Hallek, Uwe Fuhr, Jörg Janne Vehreschild and Carolin Jakob

    Citation: BMC Cancer 2021 21:719

    Content type: Research

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  25. Liver metastasis is the most common cause of death in patients with colorectal cancer (CRC). Phosphatase of regenerating liver-3 induces CRC metastasis by epithelial-to-mesenchymal transition, which promotes C...

    Authors: Heyang Xu, Qiusheng Lan, Yongliang Huang, Yang Zhang, Yujie Zeng, Pengwei Su, Ziqiang Chu, Wei Lai and Zhonghua Chu

    Citation: BMC Cancer 2021 21:718

    Content type: Research

    Published on:

  26. Because there is no exact therapeutic target, the systemic treatment of triple-negative breast cancer (TNBC) still relies on chemotherapy. In terms of local treatment, based on the highly malignant characteris...

    Authors: Leqian Guo, Guilan Xie, Ruiqi Wang, Liren Yang, Landi Sun, Mengmeng Xu, Wenfang Yang and Mei Chun Chung

    Citation: BMC Cancer 2021 21:717

    Content type: Research

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  27. Cumulative evidences have been implicated cancer stem cells in the tumor environment of hepatocellular carcinoma (HCC) cells, whereas the biological functions and prognostic significance of stemness related ge...

    Authors: Liang Hong, Yu Zhou, Xiangbang Xie, Wanrui Wu, Changsheng Shi, Heping Lin and Zhenjing Shi

    Citation: BMC Cancer 2021 21:716

    Content type: Research article

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  28. Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths in Africa. In Africa, the major causes of HCC include chronic infection with hepatitis B virus (HBV) and/or hepatitis C viru...

    Authors: Ottovon Bismark Dakurah, Cynthia Raissa Tchuem Tamandjou, Moleen Zunza, Wolfgang Preiser and Tongai Gibson Maponga

    Citation: BMC Cancer 2021 21:715

    Content type: Research

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  29. Enhancer of zesta homologue 2 (EZH2) is an essential component of polycomb repressive complex 2 (PRC2) that contributes to tumor progression and chemo-resistance. The aim of this study was to comprehensively a...

    Authors: Brett M. Reid, Shraddha Vyas, Zhihua Chen, Ann Chen, Peter A. Kanetsky, Jennifer B. Permuth, Thomas A. Sellers and Ozlen Saglam

    Citation: BMC Cancer 2021 21:714

    Content type: Research

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  30. Acute promyelocytic leukemia (APL) is a subset of acute myeloid leukemia (AML) which is characterized by the fusion of promyelocytic leukemia PML and retinoic acid receptor- alpha (RAR-alpha) genes. All-trans ...

    Authors: Mariam Fatima, Salik Javed Kakar, Fazal Adnan, Khalid Khan, Afsar Ali Mian and Dilawar Khan

    Citation: BMC Cancer 2021 21:713

    Content type: Research

    Published on:

  31. Esophageal and gastric cancers are a significant public health problem worldwide, with most patients presenting with advanced-stage disease and, consequently, poor prognosis. Systemic oncological treatments (S...

    Authors: M. Santero, J. Pérez-Bracchiglione, R. Acosta-Dighero, A. G. Meade, A. Antequera, A. Auladell-Rispau, M. J. Quintana, C. Requeijo, G. Rodríguez-Grijalva, K. Salas-Gama, R. Dorantes-Romandia, J. Salazar, I. Solà, G. Urrútia and X. Bonfill Cosp

    Citation: BMC Cancer 2021 21:712

    Content type: Research

    Published on:

  32. This study aims to provide new insights on the role of smoking patterns and cigarette dependence in female lung cancer, and to examine differences by histological subtype.

    Authors: Jennifer Rusmaully, Nastassia Tvardik, Diane Martin, Régine Billmann, Sylvie Cénée, Martine Antoine, Hélène Blons, Pierre Laurent-Puig, Jean Trédaniel, Marie Wislez, Isabelle Stücker, Pascal Guénel and Loredana Radoï

    Citation: BMC Cancer 2021 21:711

    Content type: Research article

    Published on:

  33. There is no evidence whether it is best to stop drinking alcohol at all or whether it is okay to drink a little in that light-to-moderate alcohol use was associated with low cardiovascular disease (CVD) compar...

    Authors: Gyeongsil Lee, Seogsong Jeong, Seulggie Choi, Kyae Hyung Kim, Jooyoung Chang, Seong Rae Kim, Kyuwoong Kim, Joung Sik Son, Sung Min Kim, Daein Choi and Sang Min Park

    Citation: BMC Cancer 2021 21:710

    Content type: Research

    Published on:

  34. Though sepsis is common in patients with cancer, there are limited studies that evaluated sepsis and septic shock in this patient population. The objective of this study was to evaluate the outcomes and to ide...

    Authors: Wedad B. Awad, Lama Nazer, Salam Elfarr, Maha Abdullah and Feras Hawari

    Citation: BMC Cancer 2021 21:709

    Content type: Research

    Published on:

  35. In the surgical treatment of intrahepatic cholangiocarcinoma (ICC), postoperative complications may be predictive of long-term survival. This study aimed to identify an immune-nutritional index (INI) that can ...

    Authors: Tatsuo Matsuda, Yuzo Umeda, Tadakazu Matsuda, Yoshikatsu Endo, Daisuke Sato, Toru Kojima, Kenta Sui, Masaru Inagaki, Tetsuya Ota, Masayoshi Hioki, Masahiro Oishi, Masashi Kimura, Toshihiro Murata, Nobuhiro Ishido, Takahito Yagi and Toshiyoshi Fujiwara

    Citation: BMC Cancer 2021 21:708

    Content type: Research

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  36. The 21-gene recurrence score (RS) can predict chemotherapy benefit in estrogen receptor-positive, human epidermal growth factor receptor-2-negative (ER+/HER2-) early breast cancer patients. Age would influence...

    Authors: Jing Yu, Caijin Lin, Jiahui Huang, Jin Hong, Weiqi Gao, Siji Zhu, Lin Lin, Xiaosong Chen, Ou Huang, Jianrong He, Li Zhu, Weiguo Chen, Yafen Li, Jiayi Wu and Kunwei Shen

    Citation: BMC Cancer 2021 21:707

    Content type: Research article

    Published on:

  37. Epidemiological evidence suggests that synchronous or metachronous presentation of breast and thyroid cancers exceeds that predicted by chance alone. The following potential explanations have been hypothesized...

    Authors: Bence Bakos, András Kiss, Kristóf Árvai, Balázs Szili, Barbara Deák-Kocsis, Bálint Tobiás, Zsuzsanna Putz, Richárd Ármós, Bernadett Balla, János Kósa, Magdolna Dank, Zsuzsanna Valkusz, István Takács, Ádám Tabák and Péter Lakatos

    Citation: BMC Cancer 2021 21:706

    Content type: Research article

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  38. Our previous studies have reported the down-regulation of EGFL8 correlates to the development and prognosis of colorectal and gastric cancer. The present study is carried out to explore the expression pattern ...

    Authors: Fan Wu, Fang-Yong Zhang, Guo-Qian Tan, Wei-Jia Chen, Biao Huang, Lun Yan, Hao-Lu Zhang, Shi Chen, Yang Jiao and Bai-Lin Wang

    Citation: BMC Cancer 2021 21:704

    Content type: Research

    Published on:

  39. Cancer stemness is associated with metastases in kidney renal clear cell carcinoma (KIRC) and negatively correlates with immune infiltrates. Recent stemness evaluation methods based on the absolute expression ...

    Authors: Lixing Xiao, Guoying Zou, Rui Cheng, Pingping Wang, Kexin Ma, Huimin Cao, Wenyang Zhou, Xiyun Jin, Zhaochun Xu, Yan Huang, Xiaoyu Lin, Huan Nie and Qinghua Jiang

    Citation: BMC Cancer 2021 21:703

    Content type: Research

    Published on:

  40. We conducted a single-arm phase II trial to investigate the short-term efficacy and safety of apatinib combined with oxaliplatin and S-1 in the treatment of unresectable gastric cancer.

    Authors: Zaisheng Ye, Yi Zeng, Shenghong Wei, Yi Wang, Zhitao Lin, Shu Chen, Zhiwei Wang, Shanshan Chen and Luchuan Chen

    Citation: BMC Cancer 2021 21:702

    Content type: Research

    Published on:

  41. We evaluated the treatment response and predictive factors for overall survival (OS) in patients with hepatocellular carcinoma (HCC) and portal vein tumour thrombosis (PVTT), who underwent stereotactic body ra...

    Authors: Xiaojie Li, Zhimin Ye, Sheng Lin and Haowen Pang

    Citation: BMC Cancer 2021 21:701

    Content type: Research

    Published on:

  42. Inflammation plays an important role in tumor proliferation, metastasis, and resistance to chemotherapy. The systemic inflammation response index (SIRI), has been reported to be closely related to prognosis in...

    Authors: Jie Dong, Qingqing Sun, Yueyin Pan, Nannan Lu, Xinghua Han and Qiong Zhou

    Citation: BMC Cancer 2021 21:700

    Content type: Research

    Published on:

  43. An unexpected recurrence of hepatocellular carcinoma (HCC) sometimes occurs in patients with hepatitis C virus (HCV) after treatment with direct-acting antivirals (DAAs). However, the characteristics of patien...

    Authors: Takao Watanabe, Yoshio Tokumoto, Kouji Joko, Kojiro Michitaka, Norio Horiike, Yoshinori Tanaka, Fujimasa Tada, Yoshiyasu Kisaka, Seiji Nakanishi, Kazuhiko Yamauchi, Hironori Ochi, Atsushi Hiraoka, Sen Yagi, Atsushi Yukimoto, Masashi Hirooka, Masanori Abe…

    Citation: BMC Cancer 2021 21:699

    Content type: Research article

    Published on:

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