Soft tissue sarcoma (STS) comprises a family of rare, heterogeneous tumors of mesenchymal origin. Single-agent doxorubicin remains the first-line standard-of-care treatment for advanced and inoperable STS, but...
Authors: Jasmien Cornillie, Agnieszka Wozniak, Britt Van Renterghem, Nathalie Van Winkel, Jasmien Wellens, Yemarshet K. Gebreyohannes, Maria Debiec-Rychter, Raf Sciot, Daphne Hompes and Patrick Schöffski
Copy number gain of the D-3-phosphoglycerate dehydrogenase (PHGDH) gene, which encodes the first enzyme in serine biosynthesis, is found in some human cancers including a subset of melanomas.
Authors: Katherine R. Mattaini, Mark R. Sullivan, Allison N. Lau, Brian P. Fiske, Roderick T. Bronson and Matthew G. Vander Heiden
Pathogenic variants (PVs) of BRCA genes entail a lifetime risk of developing breast cancer in 50–85% of carriers. Their prevalence in different populations has been previously reported. However, there is scarc...
Authors: Omar Alejandro Zayas-Villanueva, Luis Daniel Campos-Acevedo, José de Jesús Lugo-Trampe, David Hernández-Barajas, Juan Francisco González-Guerrero, María Fernanda Noriega-Iriondo, Ilse Alejandra Ramírez-Sánchez and Laura Elia Martínez-de-Villarreal
The aim of this study was to assess the prognostic significance of preoperative systemic inflammation score (SIS) on patients with esophageal squamous cell carcinoma (ESCC).
Authors: Xiaobin Fu, Tingting Li, Yaqing Dai and Jiancheng Li
Interstitial pneumonitis is a rare reaction in a previously irradiated area of pulmonary or thoracic lesion after treatment with anticancer drugs such as taxanes.
Authors: Yoshinori Yanai, Takeo Kosaka, Hiroshi Hongo and Mototsugu Oya
Recently, the incidence of gastroesophageal junction (GEJ) cancer has been increasing in Eastern countries. Mediastinal lymph node (MLN) metastasis rates among patients with GEJ cancer are reported to be 5–25%...
Authors: Won Ho Han, Bang Wool Eom, Hong Man Yoon, Daniel Reim, Young-Woo Kim, Moon Soo Kim, Jong Mog Lee and Keun Won Ryu
Mouse clinical trials (MCTs) are becoming wildly used in pre-clinical oncology drug development, but a statistical framework is yet to be developed. In this study, we establish such as framework and provide ge...
Authors: Sheng Guo, Xiaoqian Jiang, Binchen Mao and Qi-Xiang Li
Ependymal tumors are pathologically defined intrinsic neoplasms originating in the intracranial compartments or the spinal cord that affect both children and adults. The recently integrated classification of e...
Authors: Shaoyan Xi, Ke Sai, Wanming Hu, Fang Wang, Yinsheng Chen, Jing Wang, Jing Zeng and Zhongping Chen
Assessing the prognostic significance of specific clinicopathological features plays an important role in surgical management after radical cystectomy. This study investigated the association between ten clini...
Authors: Lijin Zhang, Bin Wu, Zhenlei Zha, Wei Qu, Hu Zhao and Jun Yuan
The rapid development of single-cell RNA sequencing (scRNA-seq) provides unprecedented opportunities to study the tumor ecosystem that involves a heterogeneous mixture of cell types. However, the majority of p...
Authors: Xiaoqing Yu, Y. Ann Chen, Jose R. Conejo-Garcia, Christine H. Chung and Xuefeng Wang
Tongue squamous cell carcinoma (TSCC) is a special type of oral cancer. Cervical lymph node relapse may occur in a large percentage of TSCC patients, which usually indicates poor prognosis. In this cohort stud...
Authors: Kailiu Wu, Junshui Wei, Zhengwu Liu, Binbin Yu, Xi Yang, Chunye Zhang, Ahmed Abdelrehem, Chenping Zhang and Siyi Li
Identification of molecular markers for early detection or prediction of metastasis is crucial for both management of HCC patient postoperative treatment and identify new therapeutic targets to inhibit HCC pro...
Authors: Lui Ng, Virginia Kwan, Ariel Chow, Thomas Chung-Cheung Yau, Ronnie Tung-Ping Poon, Roberta Pang and Wai-Lun Law
Argonaute-2 (Ago2) is an essential component of microRNA biogenesis implicated in tumourigenesis. However Ago2 expression and localisation in breast cancer remains undetermined. The aim was to define Ago2 expr...
Authors: M.C. Casey, A. Prakash, E. Holian, A. McGuire, O. Kalinina, A. Shalaby, C. Curran, M. Webber, G. Callagy, E. Bourke, M. J. Kerin and J. A. Brown
Differentiated cells that arise from stem cells in early development contain DNA methylation features that provide a memory trace of their fetal cell origin (FCO). The FCO signature was developed to estimate t...
Authors: Ze Zhang, John K. Wiencke, Devin C. Koestler, Lucas A. Salas, Brock C. Christensen and Karl T. Kelsey
One major hallmark of colorectal cancers (CRC) is genomic instability with its contribution to tumor heterogeneity and therapy resistance. To facilitate the investigation of intra-sample phenotypes and the de ...
Authors: Timo Gemoll, Elena Miroll, Oliver Klein, Annette Lischka, Murat Eravci, Christoph Thorns and Jens K. Habermann
The clinical behaviors and cytogenetics of solitary uterine leiomyomas (SUL) and multiple uterine leiomyomas (MUL) vary, which greatly affects the choice of treatments for reproductive-aged patients with leiom...
Mexico City has one of the highest incidences and mortality rates of acute lymphoblastic leukemia (ALL) in the world and a high frequency of early relapses (17%) and early mortality (15%). Otherwise, childhood...
Authors: Juan Carlos Núñez-Enríquez, Ana Elena Gil-Hernández, Elva Jiménez-Hernández, Arturo Fajardo-Gutiérrez, Aurora Medina-Sansón, Janet Flores-Lujano, Laura Eugenia Espinoza-Hernández, David Aldebarán Duarte-Rodríguez, Raquel Amador-Sánchez, José Gabriel Peñaloza-González, José Refugio Torres-Nava, Rosa Martha Espinosa-Elizondo, Luz Victoria Flores-Villegas, Laura Elizabeth Merino-Pasaye, María Luisa Pérez-Saldivar, Elisa María Dorantes-Acosta…
Hepatitis B virus (HBV) is the leading cause of liver cancer, but the mechanisms by which HBV causes liver cancer are poorly understood and chemotherapeutic strategies to cure liver cancer are not available. A...
Authors: Joseph Torresi, Bang Manh Tran, Dale Christiansen, Linda Earnest-Silveira, Renate Hilda Marianne Schwab and Elizabeth Vincan
Glioblastoma (GBM) is an extremely deadly form of brain cancer with limited treatment options and thus novel therapeutic modalities are necessary. Histone deacetylase inhibitors (HDACi) have demonstrated clini...
Authors: Tian Ye, Liwen Wei, Ji Shi, Ke Jiang, Huizhe Xu, Lulu Hu, Lingkai Kong, Ye Zhang, Songshu Meng and Haozhe Piao
Immune checkpoint inhibitors (ICIs) were approved to have a significant antitumor activity in various tumor types. In practice, some patients do not seem to benefit from ICIs but rather to have accelerating di...
Authors: Zhi Ji, Zhi Peng, Jifang Gong, Xiaotian Zhang, Jian Li, Ming Lu, Zhihao Lu and Lin Shen
The early detection of synchronous bone metastasis (BM) in newly diagnosed colorectal cancer (CRC) affects its initial management and prognosis. A clinical model to individually predict the risk of developing ...
Authors: Xu Guan, Chen-xi Ma, Ji-chuan Quan, Shuai Li, Zhi-xun Zhao, Hai-peng Chen, Ming Yang, Zheng Liu, Zheng Jiang and Xi-shan Wang
Leukemia is a malignant neoplasm that arises from hematopoietic cells. The number of leukemia cases has dramatically increased from 297,000 to 437, 033 cases worldwide. As result, the the Saudi Cancer Registry...
Authors: Amen Bawazir, Nouf Al-Zamel, Abeer Amen, Maaged A. Akiel, Naif M. Alhawiti and Ali Alshehri
The epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer has been successfully treated with tyrosine kinase inhibitors (TKIs). Acquired resistance becomes a tough issue when pati...
Authors: Jing Liu, Bo Jin, Hang Su, Xiujuan Qu and Yunpeng Liu
Uncommon epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a rare subset of NSCLC. The aim of this study was to investigate the prevalence, characteristics, and clinical outc...
Authors: J. Chantharasamee, N. Poungvarin, P. Danchaivijitr and S. Techawatanawanna
Multiple myeloma (MM), characterized by cancerous proliferation of plasmablasts (PB) and plasma cells (PC), remains incurable in many patients. Differentially expressed molecules between MM PCs and healthy PCs...
Authors: Ying Fang, Ruonan Xu, Bing Zhai, Chunmei Hou, Ning Ma, Liang Wang, Gencheng Han, Zhenyu Jiang and Renxi Wang
Hepatocellular carcinomas (HCC) arising in the caudate lobe is rare and the treatment is difficult. The aim of this study is to summarize the experience of ultrasound-guided percutaneous ablation therapy for H...
Authors: Baoxian Liu, Jianting Long, Wei Wang, Tongyi Huang, Xiaohua Xie, Shuling Chen, Guangliang Huang, Chunlin Jiang, Jieyi Ye, Haiyi Long, Xiaoyan Xie and Ming Kuang
The clinical impact of adjuvant radiotherapy on uterine sarcoma is unclear, and may depend on the histological type. Hence, the aim of this study was to evaluate clinical outcomes of adjuvant radiotherapy afte...
In ovarian cancer, dysregulation of mRNA expression of several components of the family of the kallikrein-related peptidases (KLKs) is observed. In this study, we have analyzed the KLK5 mRNA expression pattern...
Authors: Weiwei Gong, Yueyang Liu, Christof Seidl, Eleftherios P. Diamandis, Marion Kiechle, Enken Drecoll, Matthias Kotzsch, Viktor Magdolen and Julia Dorn
It is important to identify biomarkers associated with BRCA mutation in women with early breast cancer (BC) to improve early identification of mutation carriers. Thus, in this study, we examined the protein expre...
Authors: Sabine Danzinger, Yen Yen Tan, Margaretha Rudas, Marie-Theres Kastner, Sigrid Weingartshofer, Daniela Muhr and Christian F. Singer
Current evidence suggests that patients with Luminal A early breast cancer can skip chemotherapy or extended endocrine therapy, but immunohistochemistry-based biomarker analysis for St Gallen subtyping may not...
Authors: Mark Laible, Kerstin Hartmann, Claudia Gürtler, Tobias Anzeneder, Ralph Wirtz, Stephan Weber, Thomas Keller, Ugur Sahin, Martin Rees and Annette Ramaswamy
To evaluate the safety and efficacy of intra-arterial chemotherapy (IAC) for the primary or secondary treatment of infants diagnosed with advanced retinoblastoma before 3 months of age.
Authors: Qiuying Chen, Bin Zhang, Yuhao Dong, Xiaokai Mo, Lu Zhang, Jiejun Xia, Jing Zhang and Shuixing Zhang
The protease uPA and its inhibitor PAI-1 play major roles in hemostasis and are also involved in cancer progression. This is mainly caused by their ability to degrade extracellular matrix-facilitating tumor ce...
Authors: Bruno Märkl, Martin Kazik, Nadia Harbeck, Elzbieta Jakubowicz, Reinhard Hoffmann, Thomas Jung, Dieter Steinfeld, Gerhard Schenkirsch, Günter Schlimok and Daniel Oruzio
Lung cancer is the most important cause of cancer-related deaths worldwide and the overall survival of patients with non-small cell lung cancer has not improved. Transforming growth factor beta or TGF-β is a p...
Authors: Jue Li, Cheng Shen, Xin Wang, Yutian Lai, Kun Zhou, Pengfei Li, Lunxu Liu and Guowei Che
Thyroid cancer is the most common endocrinology cancer that its incidence has increased in recent decades. miRNAs are new biomarkers in recent studies in the diagnosis and follow-up of these patients.
Authors: Mahsa Rezaei, Amir Mahdi Khamaneh, Nosratollah Zarghami, Armin Vosoughi and Shahriar Hashemzadeh
While multiagent chemotherapy has dramatically improved the prognosis of sarcoma, the novel chemotherapeutics have hardly developed over the past 30 years. Caffeine can induce apoptosis, delays in cell cycle p...
The differences in progression-free survival (PFS) and cancer-specific survival (CSS) of metastatic renal cell carcinoma (mRCC) patients according to treatment, type of metastasis, and Heng criteria risk are u...
Authors: Sung Han Kim, Dong-eun Lee, Boram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee and Jinsoo Chung
In a prospective study with long-term follow-up, we analyzed circulating T cell subsets in patients with metastatic colorectal cancer (mCRC) in the context of primary tumor sidedness, KRAS status, and clinical ou...
Authors: Beatrix Bencsikova, Eva Budinska, Iveta Selingerova, Katerina Pilatova, Lenka Fedorova, Kristina Greplova, Rudolf Nenutil, Dalibor Valik, Radka Obermannova, Michael A. Sheard and Lenka Zdrazilova-Dubska
Genetic profiling of cancers for variations in copy number, structure or expression of certain genes has improved diagnosis, risk-stratification and therapeutic decision-making. However the tumor-restricted na...
Authors: Jordan Mandel, Huabo Wang, Daniel P. Normolle, Wei Chen, Qi Yan, Peter C. Lucas, Panayiotis V. Benos and Edward V. Prochownik
Sterol-regulatory element binding protein 1 (SREBP1), an intracellular cholesterol sensor located in the endoplasmic reticulum, regulates the intracellular cholesterol by the Insig-Srebp-Scap pathway. Over-exp...
Authors: Yuyan Gao, Xianxiu Nan, Xinjue Shi, Xiaoqin Mu, Binbin Liu, Huifen Zhu, Bingqing Yao, Xinyi Liu, Tianyue Yang, Yiting Hu and Shulin Liu
Sex differences in the incidences of cancers become a critical issue in both cancer research and the development of precision medicine. However, details in these differences have not been well reported. We pro...
Authors: Daoshan Zheng, Justyna Trynda, Cecilia Williams, Jeremy A. Vold, Justin H. Nguyen, Denise M. Harnois, Sanjay P. Bagaria, Sarah A. McLaughlin and Zhaoyu Li
Longitudinal studies of tumor volume have used certain named mathematical growth models. The Bertalanffy-Pütter differential equation unifies them: It uses five parameters, amongst them two exponents related t...
Authors: Manfred Kühleitner, Norbert Brunner, Werner-Georg Nowak, Katharina Renner-Martin and Klaus Scheicher
Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant...
Authors: E. M. Guinan, A. E. Bennett, S. L. Doyle, L. O’Neill, J. Gannon, G. Foley, J. A. Elliott, J. O’Sullivan, J. V. Reynolds and J. Hussey
Competing molecular classification systems have been proposed to complement the TNM staging system for a better prediction of survival in colorectal cancer (CRC). However, validation studies are so far lacking...
Authors: Elizabeth Alwers, Hendrik Bläker, Viola Walter, Lina Jansen, Matthias Kloor, Alexander Arnold, Julia Sieber-Frank, Esther Herpel, Katrin E. Tagscherer, Wilfried Roth, Jenny Chang-Claude, Hermann Brenner and Michael Hoffmeister
Re-capture of the differences between tumor and normal tissues observed at the patient level in cell cultures and animal models is critical for applications of these cancer-related differences. The epithelial-...
Authors: Jing Song, Wenqing Wang, Yingyan Wang, Yongxin Qin, Yingzi Wang, Jian Zhou, Xuelian Wang, Yi Zhang and Qi Wang
Although the prognosis of chronic myeloid leukemia (CML) has dramatically improved, the pathogenesis of CML remains elusive. Studies have shown that sustained phosphorylation of AKT1 plays a crucial role in th...
Authors: Xiaorong Liu, Huirong Mai, Hanfang Jiang, Zhihao Xing, Dong Peng, Yuan Kong, Chunqing Zhu and Yunsheng Chen
The literature on sexual orientation disclosure is arguably one of the most developed in the field of lesbian, gay and bisexual (LGB) people in healthcare in English speaking countries however, relatively litt...
Authors: Julie Fish, Iain Williamson and Jayne Brown
Canonical WNT signalling plays a critical role in the regulation of ovarian development; mis-regulation of this key pathway in the adult ovary is associated with subfertility and tumourigenesis. The roles of A...
Authors: Noha-Ehssan Mohamed, Trevor Hay, Karen R. Reed, Matthew J. Smalley and Alan R. Clarke
Chronic lymphocytic leukemia is a malignancy with good prognosis. However, the incidence of secondary tumors increases every year after the diagnosis of chronic lymphotcytic leukemia. One of the induced second...
To compare outcomes of high-risk human papilloma virus-related oropharyngeal squamous cell carcinoma (HPV OPSCC) treated with modern radiation treatment (RT) and daily image-guidance, staged with the 7th versus t...
Authors: Kirsten van Gysen, Mark Stevens, Linxin Guo, Dasantha Jayamanne, David Veivers, Andrew Wignall, Leo Pang, Alexander Guminski, Adrian Lee, George Hruby, Paula Macleod, Alon Taylor and Thomas Eade
