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  1. The prognostic relevance of circulating tumour cells (CTCs) in metastatic breast cancer (MBC) patients has been confirmed by several clinical trials. However, predictive blood-based biomarkers for stratificati...

    Authors: Natalia Krawczyk, Melissa Neubacher, Franziska Meier-Stiegen, Hans Neubauer, Dieter Niederacher, Eugen Ruckhäberle, Svjetlana Mohrmann, Jürgen Hoffmann, Thomas Kaleta, Malgorzata Banys-Paluchowski, Petra Reinecke, Irene Esposito, Wolfgang Janni and Tanja Fehm

    Citation: BMC Cancer 2019 19:1101

    Content type: Research article

    Published on:

  2. This study aimed to assess the effect of antibiotics on the clinical outcomes of patients with solid cancers undergoing treatment with immune checkpoint inhibitors (ICIs).

    Authors: Hyunho Kim, Ji Eun Lee, Sook Hee Hong, Myung Ah. Lee, Jin Hyoung Kang and In-Ho Kim

    Citation: BMC Cancer 2019 19:1100

    Content type: Research article

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  3. There are differences in the quality of care among breast cancer patients. Narrowing the quality differences could be achieved by increasing the utilization rate of indicators. Here we explored key indicators ...

    Authors: Chao Wang, Xi Li, Shaofei Su, Xinyu Wang, Jingkun Li, Xiaoqiang Bao and Meina Liu

    Citation: BMC Cancer 2019 19:1099

    Content type: Research article

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  4. Adapting screening strategy to colorectal cancer (CRC) risk may improve efficiency for all stakeholders however limited tools for such risk stratification exist. Colorectal cancers usually evolve from advanced...

    Authors: Laura W. Musselwhite, Thomas S. Redding IV, Kellie J. Sims, Meghan C. O’Leary, Elizabeth R. Hauser, Terry Hyslop, Ziad F. Gellad, Brian A. Sullivan, David Lieberman and Dawn Provenzale

    Citation: BMC Cancer 2019 19:1097

    Content type: Research article

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  5. The aim of this study was to assess the agreement rate between intraoperative evaluation (IOE) and final diagnosis (FD) in a series of surgically resected endometrial carcinoma (EC), with a preoperative ambigu...

    Authors: A. Santoro, A. Piermattei, F. Inzani, G. Angelico, M. Valente, D. Arciuolo, S. Spadola, M. Martini, F. Fanfani, A. Fagotti, V. Gallotta, G. Scambia and G. F. Zannoni

    Citation: BMC Cancer 2019 19:1096

    Content type: Research article

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  6. Circulating extracelluar vesicles (EVs) in epithelial ovarian cancer (EOC) patients emanate from multiple cells. These EVs are emerging as a new type of biomarker as they can be obtained by non-invasive approa...

    Authors: Wei Zhang, Peng Peng, Xiaoxuan Ou, Keng Shen and Xiaohua Wu

    Citation: BMC Cancer 2019 19:1095

    Content type: Research article

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  7. The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide in recent years. Therefore, novel potential therapeutic targets for PTC are urgently needed. Enhancer of zeste homolog 2 (EZH2),...

    Authors: Liqiong Xue, Hongzhu Yan, Ying Chen, Qifa Zhang, Xin Xie, Xiaoying Ding, Xiaojing Wang, Zhongqing Qian, Feng Xiao, Zhiyi Song, Yijie Wu, Yongde Peng and Huanbai Xu

    Citation: BMC Cancer 2019 19:1094

    Content type: Research article

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  8. The evasion of apoptosis is a hallmark of cancer. Understanding this process holistically and overcoming apoptosis resistance is a goal of many research teams in order to develop better treatment options for c...

    Authors: Manuela Salvucci, Zaitun Zakaria, Steven Carberry, Amanda Tivnan, Volker Seifert, Donat Kögel, Brona M. Murphy and Jochen H. M. Prehn

    Citation: BMC Cancer 2019 19:1092

    Content type: Review

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  9. The features and survival of stage IV breast cancer patients with different metastatic sites are poorly understood. This study aims to examine the clinicopathological features and survival of stage IV breast c...

    Authors: Ru Wang, Yayun Zhu, Xiaoxu Liu, Xiaoqin Liao, Jianjun He and Ligang Niu

    Citation: BMC Cancer 2019 19:1091

    Content type: Research article

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  10. Abnormal autocrine fibroblast growth factor 19 (FGF19) production has been observed in several types of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the potential of serum ...

    Authors: Takahiro Maeda, Hiroaki Kanzaki, Tetsuhiro Chiba, Junjie Ao, Kengo Kanayama, Susumu Maruta, Yuko Kusakabe, Tomoko Saito, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Sadahisa Ogasawara, Eiichiro Suzuki, Yoshihiko Ooka, Shingo Nakamoto, Ryo Nakagawa…

    Citation: BMC Cancer 2019 19:1088

    Content type: Research article

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  11. SOX2 is regarded as an important marker in stem cell. The change of SOX2 expression after adjuvant therapy in high grade glioma (HGG) remains unknown so far. Few patients with recurrent glioma have opportunity...

    Authors: Wei Yu, Xiaoqiu Ren, Chunxiu Hu, Yinuo Tan, Yongjie Shui, Zexin Chen, Lili Zhang, Jiaping Peng and Qichun Wei

    Citation: BMC Cancer 2019 19:1087

    Content type: Research article

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  12. Cytokeratin 7 (CK7) and GATA binding protein 3 (GATA3) are considered as immunohistochemical hallmarks of breast cancers; however, there are breast tumors lacking these markers. Clinicopathological characteriz...

    Authors: Shaolei Lu, Evgeny Yakirevich, Li Juan Wang, Murray B. Resnick and Yihong Wang

    Citation: BMC Cancer 2019 19:1085

    Content type: Research article

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  13. Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients. However, their prognostic values in patients with diffuse lar...

    Authors: Manman Li, Hailong Xia, Huimin Zheng, Yafeng Li, Jun Liu, Linhui Hu, Jingrong Li, Yangyang Ding, Lianfang Pu, Qianle Gui, Yijie Zheng, Zhimin Zhai and Shudao Xiong

    Citation: BMC Cancer 2019 19:1084

    Content type: Research article

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  14. Hepatoma-derived growth factor (HDGF) participates in angiogenesis and represents a negative prognostic factor in oral cancer. The current study was designed to elucidate the regulatory mechanism between HDGF ...

    Authors: Yu-Wei Lin, Shih-Tsung Huang, Jian-Ching Wu, Tian-Huei Chu, Shih-Chung Huang, Ching-Chih Lee and Ming-Hong Tai

    Citation: BMC Cancer 2019 19:1083

    Content type: Research article

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  15. It remains controversial whether weight change could influence the risks of colorectal cancer (CRC) and mortality. This study aimed to quantify the associations between full-spectrum changes in body mass index...

    Authors: Ji-Bin Li, Sheng Luo, Martin C. S. Wong, Cai Li, Li-Fen Feng, Jian-Hong Peng, Jing-Hua Li and Xi Zhang

    Citation: BMC Cancer 2019 19:1082

    Content type: Research article

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  16. Standardized Nucleic Acid Quantification for SEQuencing (SNAQ-SEQ) is a novel method that utilizes synthetic DNA internal standards spiked into each sample prior to next generation sequencing (NGS) library pre...

    Authors: Daniel J. Craig, Thomas Morrison, Sadik A. Khuder, Erin L. Crawford, Leihong Wu, Joshua Xu, Thomas M. Blomquist and James C. Willey

    Citation: BMC Cancer 2019 19:1081

    Content type: Technical advance

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  17. The upregulated expression of the JAK/STAT pathway promotes tumor growth in Hodgkin lymphoma (HL) and primary mediastinal large B-cell lymphoma (PMBCL). Based on the hypothesis that JAK2 is a therapeutic targe...

    Authors: Seok Jin Kim, Dok Hyun Yoon, Hye Jin Kang, Jung Yong Hong, Ho Sup Lee, Sung Yong Oh, Ho-Jin Shin, Jee Hyun Kong, Jun Ho Yi, Kana Sakamoto, Young Hyeh Ko, Jooryung Huh, Seung-Sook Lee, Kengo Takeuchi, Dong-Yeop Shin, Cheolwon Suh…

    Citation: BMC Cancer 2019 19:1080

    Content type: Research article

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  18. High perioperative morbidity, mortality, and uncertain outcome of surgery in octogenarians with proximal gastric carcinoma (PGC) pose a dilemma for both patients and physicians. We aim to evaluate the risks an...

    Authors: Xuefei Wang, Junjie Zhao, Mark Fairweather, Tingsong Yang, Yihong Sun and Jiping Wang

    Citation: BMC Cancer 2019 19:1079

    Content type: Research article

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  19. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived reactive oxygen species (ROS) not only can promote cancer progression, but also they have recently emerged as mediators of the mucosal immune...

    Authors: Sang Yeon Cho, Sungha Kim, Mi-Ju Son, Gwanghun Kim, Parul Singh, Ha Neul Kim, Hei-Gwon Choi, Heon Jong Yoo, Young Bok Ko, Byung Seok Lee and Hyuk Soo Eun

    Citation: BMC Cancer 2019 19:1078

    Content type: Research article

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  20. BRCA1 associated-protein 1 (BAP1) tumor predisposition syndrome is associated with an increased risk for malignant mesotheliomas, uveal and cutaneous melanomas, renal cell carcinomas, and singular cutaneous lesio...

    Authors: Bianca Costa Soares de Sá, Mariana Petaccia de Macedo, Giovana Tardin Torrezan, Juliana Casagrande Tavoloni Braga, Felipe Fidalgo, Luciana Facure Moredo, Rute Lellis, João Pereira Duprat and Dirce Maria Carraro

    Citation: BMC Cancer 2019 19:1077

    Content type: Case report

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  21. Conflicting results have been reported on the influence of carbohydrates in breast cancer.

    Authors: Tone Hoel Lende, Marie Austdal, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Jan Terje Kvaløy, Lars A. Akslen, Håvard Søiland, Emiel A. M. Janssen and Jan P. A. Baak

    Citation: BMC Cancer 2019 19:1076

    Content type: Research article

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  22. Radiotherapy failure is a significant clinical challenge due to the development of resistance in the course of treatment. Therefore, it is necessary to further study the radiation resistance mechanism of HCC. ...

    Authors: Ze-Tian Shen, Ying Chen, Gui-Chun Huang, Xi-Xu Zhu, Rui Wang and Long-Bang Chen

    Citation: BMC Cancer 2019 19:1075

    Content type: Research article

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  23. Hypofractionated palliative radiotherapy for metastatic lung cancer patients is frequently used in order to ease pain, to increase bone stability, to treat local mass effects, or to prolong progression-free su...

    Authors: Farastuk Bozorgmehr, Adriane Hommertgen, Johannes Krisam, Felix Lasitschka, Jonas Kuon, Martin Maenz, Peter E. Huber, Laila König, Meinhard Kieser, Juergen Debus, Michael Thomas and Stefan Rieken

    Citation: BMC Cancer 2019 19:1074

    Content type: Study protocol

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  24. To measure changes in four common chemotherapy related side-effects (low energy, stress, nausea and pain) immediately after a single exercise session within the first week after treatment.

    Authors: Anna Johnsson, Ingrid Demmelmaier, Katarina Sjövall, Philippe Wagner, Håkan Olsson and Åsa B. Tornberg

    Citation: BMC Cancer 2019 19:1073

    Content type: Research article

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  25. DNMT3A R882H, a frequent mutation in acute myeloid leukemia (AML), plays a critical role in malignant hematopoiesis. Recent findings suggest that DNMT3A mutant acts as a founder mutation and requires additional g...

    Authors: Xiaodong Shi, Ying Yang, Siqi Shang, Songfang Wu, Weina Zhang, Lijun Peng, Ting Huang, Ruihong Zhang, Ruibao Ren, Jianqing Mi and Yueying Wang

    Citation: BMC Cancer 2019 19:1072

    Content type: Research article

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  26. Although numerous studies have investigated the clinicopathologic and prognostic relevance of mucinous adenocarcinoma (MAC) and signet-ring cell carcinoma (SRCC) compared with classic adenocarcinoma (CA), litt...

    Authors: Hui Sheng, Xiaoli Wei, Minjie Mao, Jincan He, Tianqi Luo, Shilin Lu, Liye Zhou, Zhixin Huang and Anli Yang

    Citation: BMC Cancer 2019 19:1071

    Content type: Research article

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  27. Increase of circulating tumor cells (CTCs) has been found after surgery for various carcinomas but not confirmed for breast cancer, and whether endoscopic surgery confers identical effect to CTCs as open surge...

    Authors: Shichao Li, Wenting Yan, Xinhua Yang, Li Chen, Linjun Fan, Haoxi Liu, Kun Liu, Yi Zhang and Jun Jiang

    Citation: BMC Cancer 2019 19:1070

    Content type: Research article

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  28. The single-nucleotide polymorphism SLC39A6 rs1050631 is strongly implicated in esophageal squamous cell carcinoma, leading us to question whether it may also play a role in gastric adenocarcima (GA).

    Authors: Jian Gao, Wenjun Ren, Chunhong Xiao, Lie Wang, Qiaojia Huang, Zaizhong Zhang, Yuan Dang, Pengcheng Weng, Hui Wang, Xuehong Fang, Minxian Zhuang, Liying Lin and Shaoquan Chen

    Citation: BMC Cancer 2019 19:1069

    Content type: Research article

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  29. Accumulating evidence indicates inherited risk in the aetiology of lung cancer, although smoking exposure is the major attributing factor. Family history is a simple substitute for inherited susceptibility. Pr...

    Authors: Yue I. Cheng, Yun Cui Gan, Dan Liu, Michael P. A. Davies, Wei Min Li and John K. Field

    Citation: BMC Cancer 2019 19:1068

    Content type: Research article

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  30. Three-weekly high-dose cisplatin (100 mg/m2) is considered the standard systemic regimen given concurrently with postoperative or definitive radiotherapy in locally advanced squamous cell carcinoma of the head an...

    Authors: Maurice J. D. L. van der Vorst, Elisabeth C. W. Neefjes, Elisa C. Toffoli, Jolanda E. W. Oosterling-Jansen, Marije R. Vergeer, C. René Leemans, Menno P. Kooistra, Jens Voortman and Henk M. W. Verheul

    Citation: BMC Cancer 2019 19:1066

    Content type: Research article

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  31. Triple negative breast cancer (TNBC) represents 15–20% of breast cancers. Due to its heterogeneity and high rates of relapse, there is a need to optimize treatment efficacy. Platinum chemotherapy is still cont...

    Authors: Jessa Gilda P. Pandy, Joanmarie C. Balolong-Garcia, Mel Valerie B. Cruz-Ordinario and Frances Victoria F. Que

    Citation: BMC Cancer 2019 19:1065

    Content type: Research article

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  32. Prostate cancer is one of the most common cancers in the world. The results of treatment after hypofractionated radiotherapy only have been reported from several small randomized clinical trials. Therefore, we...

    Authors: Wei Guo, Yun-Chuan Sun, Jian-Qiang Bi, Xin-Ying He and Li Xiao

    Citation: BMC Cancer 2019 19:1063

    Content type: Research article

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  33. To reveal roles of reactive oxygen species (ROS) status in chemotherapy resistance and to develop a ROS scoring system for prognosis prediction in ovarian cancer.

    Authors: Chaoyang Sun, Ensong Guo, Bo Zhou, Wanying Shan, Jia Huang, Danhui Weng, Peng Wu, Changyu Wang, Shixuan Wang, Wei Zhang, Qinglei Gao, Xiaoyan Xu, Beibei Wang, Junbo Hu, Ding Ma and Gang Chen

    Citation: BMC Cancer 2019 19:1061

    Content type: Research article

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  34. The computed tomography (CT) features of small solid lung cancers and their changing regularity as they grow have not been well studied. The purpose of this study was to analyze the CT features of solid lung c...

    Authors: Zhi-gang Chu, Yan Zhang, Wang-jia Li, Qi Li, Yi-neng Zheng and Fa-jin Lv

    Citation: BMC Cancer 2019 19:1060

    Content type: Research article

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  35. Long non-coding RNAs (lncRNAs) play a fundamental role in colorectal cancer (CRC) development, however, lncRNA expression profiles in CRC and its precancerous stages remain to be explored. We aimed to study wh...

    Authors: Alexandra Kalmár, Zsófia Brigitta Nagy, Orsolya Galamb, István Csabai, András Bodor, Barnabás Wichmann, Gábor Valcz, Barbara Kinga Barták, Zsolt Tulassay, Peter Igaz and Béla Molnár

    Citation: BMC Cancer 2019 19:1059

    Content type: Research article

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  36. Globally, epidemiological evidence suggests cancer incidence and outcomes among Indigenous peoples are a growing concern. Although historically cancer among First Nations (FN) peoples in Canada was relatively ...

    Authors: Tara C. Horrill, Lindsey Dahl, Esther Sanderson, Garry Munro, Cindy Garson, Carole Taylor, Randy Fransoo, Genevieve Thompson, Catherine Cook, Janice Linton and Annette S. H. Schultz

    Citation: BMC Cancer 2019 19:1055

    Content type: Research article

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  37. Bladder cancer (BC) has become a major worldwide public health issue, especially non-muscle-invasive bladder cancer (NMIBC). A flood of related clinical practice guidelines (CPGs) have emerged; however, the qu...

    Authors: Jing Zhang, Yunyun Wang, Hong Weng, Danqi Wang, Fei Han, Qiao Huang, Tong Deng, Xinghuan Wang and Yinghui Jin

    Citation: BMC Cancer 2019 19:1054

    Content type: Research article

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  38. Pancreatic cancer is characterized by a highly immunosuppressive tumor microenvironment and evasion of immune surveillance. Although programmed cell death 1 receptor (PD-1) blockade has achieved certain succes...

    Authors: Guoping Ding, Tao Shen, Chen Yan, Mingjie Zhang, Zhengrong Wu and Liping Cao

    Citation: BMC Cancer 2019 19:1053

    Content type: Research article

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  39. Local consolidative treatment (LCT) is important for oligometastasis, defined as the restricted metastatic capacity of a tumor. This study aimed to determine the effects and prognostic heterogeneity of LCT in ...

    Authors: Jia-Tao Zhang, Si-Yang Liu, Hong-Hong Yan, Yi-Long Wu, Qiang Nie and Wen-Zhao Zhong

    Citation: BMC Cancer 2019 19:1051

    Content type: Research article

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  40. Diffuse large B-cell lymphoma (DLBCL) is characterized by its clinical and biological heterogeneity. The clinical prognostic implications of tumor-associated macrophages (TAMs) in DLBCL remain controversial an...

    Authors: Yan-Li Li, Zhi-Hu Shi, Xian Wang, Kang-Sheng Gu and Zhi-Min Zhai

    Citation: BMC Cancer 2019 19:1049

    Content type: Research article

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  41. Most lymph node metastasis (LNM) models for early gastric cancer (EGC) include lymphovascular invasion (LVI) as a predictor. However, LVI must be confirmed by postoperative pathology. In this study, we aimed t...

    Authors: Jian-Xian Lin, Zu-Kai Wang, Wei Wang, Jacopo Desiderio, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li, Amilcare Parisi, Zhi-Wei Zhou and Chang-Ming Huang

    Citation: BMC Cancer 2019 19:1048

    Content type: Research article

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  42. The application of laparoscopic liver resection (LLR) has expanded rapidly in recent decades. Although multiple authors have reported LLR shows improved safety and efficacy in treating hepatocellular carcinoma...

    Authors: Zi-Yu Wang, Qing-Lian Chen, Ling-Ling Sun, Shu-Ping He, Xiao-Fen Luo, Li-Shuang Huang, Jun-Hai Huang, Cheng-Ming Xiong and Chong Zhong

    Citation: BMC Cancer 2019 19:1047

    Content type: Research article

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  43. Assessment of preoperative general condition to predict postoperative outcomes is important, particularly in older patients who typically suffer from various comorbidities and exhibit impaired functional statu...

    Authors: Yuka Ahiko, Dai Shida, Tomoko Horie, Taro Tanabe, Yasuyuki Takamizawa, Ryohei Sakamoto, Konosuke Moritani, Shunsuke Tsukamoto and Yukihide Kanemitsu

    Citation: BMC Cancer 2019 19:946

    Content type: Research article

    Published on:

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