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  1. Cuproptosis is a newly discovered programmed cell death dependent on mitochondrial respiratory disorder induced by copper overload. Pyruvate dehydrogenase E1 subunit beta (PDHB) is one of the cuproptosis genes...

    Authors: Hu Wang, Zhan Yang, Xingyu He, Fengran Guo, Hao Sun, Sen Xu, Chao Xu, Zhu Wang, Hongzhuang Wen, Zhihai Teng, Yaxuan Wang and Zhenwei Han
    Citation: BMC Cancer 2023 23:804
    Content type: Research Published on:

  2. Cervical cancer represents one of the most prevalent cancers among women worldwide, particularly in low- and middle-income nations. Oncolytic viruses (OVs) can infect cancer cells selectively and lethally with...

    Authors: Mehdi Samadi, Talat Mokhtari-Azad, Ahmad Nejati, Zahra Norooz-Babaei, Abbas Rahimi Foroushani, Mohammad Reza Haghshenas, Fatemeh Adjaminejad, Hedieh Zargaran, Vahid Salimi and Amir Ghaemi
    Citation: BMC Cancer 2023 23:803
    Content type: Research Published on:

  3. We aimed to identify tumor-associated antigen (TAA) biomarkers through bioinformatic analysis and experimental verification, and to evaluate a panel of autoantibodies against tumor-associated antigens (TAAbs) ...

    Authors: Weihong Xie, Guiying Sun, Junfen Xia, Huili Chen, Chen Wang, Juan Lin and Peng Wang
    Citation: BMC Cancer 2023 23:802
    Content type: Research Published on:

  4. Giant breast malignant phyllodes tumor or sarcoma (GBPS) are rare entities with diameter larger than 10 cm and variously histological pleomorphisms. This disease poses a significant threat to the quality of li...

    Authors: Naiquan Liu, Ye Kang, Ningxin Qu, Chenhui Kong and Ye Han
    Citation: BMC Cancer 2023 23:801
    Content type: Research Published on:

  5. Pemetrexed is an efficacious multi-targeted antifolate with acceptable toxicity for non-squamous non-small cell lung cancer (non-Sq NSCLC) and malignant pleural mesothelioma. Vitamin B12 and folic acid as prem...

    Authors: Yuichiro Takeda, Go Naka, Yuki Katsuya, Konomi Kobayashi, Manabu Suzuki, Masao Hashimoto, Satoshi Hirano and Yukari Uemura
    Citation: BMC Cancer 2023 23:800
    Content type: Research Published on:

  6. In research designs that rely on observational ratings provided by two raters, assessing inter-rater reliability (IRR) is a frequently required task. However, some studies fall short in properly utilizing stat...

    Authors: Ming Li, Qian Gao and Tianfei Yu
    Citation: BMC Cancer 2023 23:799
    Content type: Matters Arising Published on:

    The Research to this article has been published in BMC Cancer 2022 22:1285

  8. The optimal treatment for multiple brain metastases has been recently controversially discussed.This study was aimed to explore the feasibility of Hippocampus-Avoidance Whole-Brain Radiotherapy plus a simultan...

    Authors: Xiaoliang Wang, Jinping Chen, Zhanquan Lei, Haihong Chen, Yufang Zhang, Gang Liu, Shaomin Li, Zhenhua Zheng and Hui Wang
    Citation: BMC Cancer 2023 23:796
    Content type: Research article Published on:

  9. The aim of study was to evaluate survival outcome and limb function in cancer patients with proximal limbs metastasis. Associated factors on survival outcome and limb function were identified. The comparative ...

    Authors: Chao Zhang, Jun Wang, Haixiao Wu, Yile Lin, Vladimir P. Chekhonin, Karl Peltzer, Artem V. Bukharov, Andrey D. Kaprin, Xu Guo and Zheng Liu
    Citation: BMC Cancer 2023 23:795
    Content type: Research Published on:

  10. Lung cancer screening in high-risk populations with low-dose computed tomography is supported by international associations and recommendations. Overdiagnosis is considered a risk of screening with associated ...

    Authors: Asha Bonney, Kayo Togawa, Michelle Ng, Michael Christie, Kwun M Fong, Henry Marshall, Katharine See, Cameron Patrick, Daniel Steinfort and Renee Manser
    Citation: BMC Cancer 2023 23:794
    Content type: Research Published on:

  11. The association between specific genetic mutations and immunotherapy benefits has been widely known, while such studies in pan-cancer are still limited. SPEN, mainly involved in X chromosome inactivation (XCI)...

    Authors: Ya-Dong Li, Hao Huang, Zheng-Ju Ren, Ye Yuan, Hao Wu and Chuan Liu
    Citation: BMC Cancer 2023 23:793
    Content type: Research Published on:

  12. Patients with triple-negative breast cancer (TNBC) are generally younger and more likely to experience disease recurrence and have the shortest survival among all breast cancer patients. Recently, neoadjuvant ...

    Authors: Javier Cortes, Amin Haiderali, Min Huang, Wilbur Pan, Peter Schmid, Katherine G. Akers, Julie E. Park, Andrew M. Frederickson, Peter A. Fasching and Joyce O’Shaughnessy
    Citation: BMC Cancer 2023 23:792
    Content type: Research Published on:

  13. The optimal first-line immunotherapy regimen for advanced non-squamous non-small cell lung cancer (NS-NSCLC) patients with programmed cell death ligand 1 (PD-L1) expression ≥ 50% remains unclear. Our aim is to...

    Authors: Wei Chen, Jiayi Chen, Lin Zhang, Sheng Cheng and Junxian Yu
    Citation: BMC Cancer 2023 23:791
    Content type: Research Published on:

  14. To improve prediction, the AJCC staging system was revised to be consistent with upfront surgery (UFS) and neoadjuvant therapy (NAT) for PDAC.

    Authors: Lingyu Zhu, Shuo Shen, Huan Wang, Guoxiao Zhang, Xiaoyi Yin, Xiaohan Shi, Suizhi Gao, Jiawei Han, Yiwei Ren, Jian Wang, Hui Jiang, Shiwei Guo and Gang Jin
    Citation: BMC Cancer 2023 23:790
    Content type: Research Published on:

  15. This study aimed to evaluate the potential of exosomes from cancer cells to predict chemoresistance in pancreatic cancer (PC) and explore the molecular mechanisms through RNA-sequencing and mass spectrometry. ...

    Authors: Yuhan Yang, Haitao Gu, Kundong Zhang, Zengya Guo, Xiaofeng Wang, Qingyun Wei, Ling Weng, Xuan Han, Yan Lv, Meng Cao, Peng Cao, Chen Huang and Zhengjun Qiu
    Citation: BMC Cancer 2023 23:789
    Content type: Research Published on:

  16. Glioblastoma (GBM) is the most common primary, malignant brain tumour with a 5-year survival of 5%. If possible, a glioblastoma is resected and further treated with chemoradiation therapy (CRT), but resection ...

    Authors: Céline L.G. Neutel, Ilaria Viozzi, Christiaan G. Overduin, Anne Rijpma, Janneke P.C. Grutters, Gerjon Hannink, Pieter van Eijsden, Pierre A. Robe, Maroeska M. Rovers and Mark ter Laan
    Citation: BMC Cancer 2023 23:788
    Content type: Study Protocol Published on:

  17. Clinical trials have shown that anti-PD1 therapy, either as a monotherapy or in combination, is effective and well-tolerated in patients with recurrent or unresectable hepatocellular carcinoma (HCC). In this s...

    Authors: Xindan Kang, Jing Wang, Xue Kang and Li Bai
    Citation: BMC Cancer 2023 23:787
    Content type: Research Published on:

  19. To compare the therapeutic efficacy and safety of microwave ablation (MWA) and lauromacrogol injection for ablation (LIA) for benign predominantly cystic thyroid nodules.

    Authors: Xin Min, Zheng Zhang, Yanwei Chen, Shuangshuang Zhao, Jingwen Ge, Huajiao Zhao, Yun Cai, Hui Chen, Jun Shao, Yanfei Jing and Baoding Chen
    Citation: BMC Cancer 2023 23:785
    Content type: Research Published on:

  20. Single-agent chemotherapy using methotrexate or actinomycin D is the first-line treatment for patients with low-risk gestational trophoblastic neoplasia. Various methotrexate-based and actinomycin D-based sing...

    Authors: Fang Jiang, Ming-yi Mao, Yang Xiang, Xin Lu, Chong-li Guan, Lan-zhou Jiao, Xi-Run Wan, Feng-Zhi Feng, Tong Ren, Jun-Jun Yang and Jun Zhao
    Citation: BMC Cancer 2023 23:784
    Content type: Study protocol Published on:

  21. There is a need for biomarkers that improve accuracy compared with current demographic risk indices to detect individuals at the highest lung cancer risk. Improved risk determination will enable more effective...

    Authors: Daniel J. Craig, Erin L. Crawford, Heidi Chen, Eric L. Grogan, Steven A. Deppen, Thomas Morrison, Sanja L. Antic, Pierre P. Massion and James C. Willey
    Citation: BMC Cancer 2023 23:783
    Content type: Research Published on:

  23. Ultra-hypofractionated image-guided stereotactic body radiotherapy (SBRT) is increasingly used for definitive treatment of localized prostate cancer. Magnetic resonance imaging-guided radiotherapy (MRgRT) faci...

    Authors: Ariel E. Marciscano, Sydney Wolfe, Xi Kathy Zhou, Christopher E. Barbieri, Silvia C. Formenti, Jim C. Hu, Ana M. Molina, David M. Nanus, Jones T. Nauseef, Douglas S. Scherr, Cora N. Sternberg, Scott T. Tagawa and Himanshu Nagar
    Citation: BMC Cancer 2023 23:781
    Content type: Study Protocol Published on:

  24. Although the standard therapy for advanced-stage hepatocellular carcinoma (HCC) is systemic chemotherapy, the combination of atezolizumab and bevacizumab (atezo + bev) with a high objective response rate may l...

    Authors: Masayuki Okuno, Takamichi Ishii, Akihiko Ichida, Akihiko Soyama, Nobuyuki Takemura, Seiko Hirono, Susumu Eguchi, Kiyoshi Hasegawa, Yasuharu Sasaki, Kohei Uemura, Norihiro Kokudo and Etsuro Hatano
    Citation: BMC Cancer 2023 23:780
    Content type: Study Protocol Published on:

  25. The optimal treatment strategy for resectable BRAF V600E mutant colorectal oligometastases (CRM) has not been established due to the rarity and rapid progression of the disease. Since the unresectable recurrence ...

    Authors: Shin Kobayashi, Hideaki Bando, Akinobu Taketomi, Takeshi Takamoto, Eiji Shinozaki, Manabu Shiozawa, Hiroki Hara, Kentaro Yamazaki, Koji Komori, Nobuhisa Matsuhashi, Takeshi Kato, Yoshinori Kagawa, Mitsuru Yokota, Eiji Oki, Keigo Komine, Shinichiro Takahashi…
    Citation: BMC Cancer 2023 23:779
    Content type: Study Protocol Published on:

  26. Skeletal muscle indices have been associated with improved peri-operative outcomes after surgical resection of non-small-cell lung cancer (NSCLC). However, it is unclear if these indices can predict long term ...

    Authors: Yeshwanth Vedire, Lindsay Nitsche, Madeline Tiadjeri, Victor McCutcheon, Jack Hall, Joseph Barbi, Sai Yendamuri and Andrew D. Ray
    Citation: BMC Cancer 2023 23:778
    Content type: Research Published on:

  27. Prehabilitation with exercise interventions during neoadjuvant chemotherapy (NACT) is effective in reducing physical and psychosocial chemotherapy-related adverse events in patients with cancer. In preclinical...

    Authors: Eva Kjeldsted, Gunn Ammitzbøll, Lars Bo Jørgensen, Alexey Lodin, Rasmus Dahlin Bojesen, Silvia Gonzalez Ceballos, Susanne Rosthøj, Anne-Vibeke Lænkholm, Søren T. Skou, Sandy Jack, Julie Gehl and Susanne Oksbjerg Dalton
    Citation: BMC Cancer 2023 23:777
    Content type: Study Protocol Published on:

  29. Inhibitors of Poly (ADP-Ribose) Polymerases (PARP) provide clinical benefit to patients with breast and ovarian cancers, by compromising the DNA repair activity of cancer cells. Although these agents extend progr...

    Authors: Shane O’Brien, Michael Butticello, Christine Thompson, Boris Wilson, Anastasia Wyce, Vivek Mahajan, Ryan Kruger, Helai Mohammad and Andy Fedoriw
    Citation: BMC Cancer 2023 23:775
    Content type: Research Published on:

  30. The tumor microenvironment (TME) plays a crucial role in tumorigenesis, progression, and therapeutic response in many cancers. This study aimed to comprehensively investigate the role of TME in colorectal canc...

    Authors: Xian-wen Guo, Rong-e Lei, Qing-nan Zhou, Guo Zhang, Bang-li Hu and Yun-xiao Liang
    Citation: BMC Cancer 2023 23:773
    Content type: Research Published on:

  31. Population based cancer registries (PBCRs) are accepted as the gold standard for estimating cancer incidence in any population. However, only 15% of the world’s population is covered by high quality cancer reg...

    Authors: Annet Nakaganda, Angela Spencer, Jackson Orem, Collins Mpamani, Henry Wabinga, Sarah Nambooze, Gertrude N. Kiwanuka, Raymond Atwine, Isla Gemmell, Andrew Jones and Arpana Verma
    Citation: BMC Cancer 2023 23:772
    Content type: Research Published on:

  32. High dose unilobar radioembolization (also termed ‘radiation lobectomy’)—the transarterial unilobar infusion of radioactive microspheres as a means of controlling tumour growth while concomitantly inducing fut...

    Authors: Daan Andel, Marnix G. E. H. Lam, Joep de Bruijne, Maarten L. J. Smits, Arthur J. A. T. Braat, Adriaan Moelker, Erik Vegt, Simeon J. S. Ruiter, Walter Noordzij, Gianluca Grazi, Giulio E. Vallati, Roel J. Bennink, Otto M. van Delden, Onno W. Kranenburg, Jan N. M. Ijzermans, Maarten W. Nijkamp…
    Citation: BMC Cancer 2023 23:771
    Content type: Study protocol Published on:

  33. Adjuvant chemotherapy is recommended as the standard treatment for patients with stage II/III resected gastric cancer. However, it is unclear whether older patients also benefit from an adjuvant chemotherapy s...

    Authors: Yu-Hsuan Shih, Hsin-Chen Lin, Po-Wei Liao, Cheng-Wei Chou, Cheng-Hsien Lin, Chiann-Yi Hsu, Chieh-Lin Jerry Teng, Feng-Hsu Wu, Shao-Ciao Luo and Shao-Hsuan Kao
    Citation: BMC Cancer 2023 23:770
    Content type: Research Published on:

  36. Older primary central nervous system lymphoma (PCNSL) patients have an inferior prognosis compared to younger patients because available evidence on best treatment is scarce and treatment delivery is challengi...

    Authors: Lisa K Isbell, Roswitha Uibeleisen, Alexander Friedl, Elvira Burger, Tatja Dopatka, Florian Scherer, Andras Orban, Eliza Lauer, Natalie Malenica, Inna Semenova, Annika Vreden, Elke Valk, Julia Wendler, Simone Neumaier, Heidi Fricker, Abed Al Hadi El Rabih…
    Citation: BMC Cancer 2023 23:767
    Content type: Study Protocol Published on:

  37. Women with early breast cancer who meet guideline-based criteria should be offered breast conserving surgery (BCS) with adjuvant radiotherapy as an alternative to mastectomy. New Zealand (NZ) has documented et...

    Authors: Karen Bartholomew, Mazin Ghafel, Sandar Tin Tin, Phyu S Aye, J Mark Elwood, Claire Hardie, Nina Scott, Jacquie Kidd, Reena Ramsaroop and Ian Campbell
    Citation: BMC Cancer 2023 23:766
    Content type: Research Published on:

  38. Although anaplastic lymphoma kinase (ALK) is overexpressed in several primary solid tumor types, its role in endometrial carcinoma (Em Ca) remains unclear.

    Authors: Ako Yokoi, Yusaku Nakamura, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Youhei Harada, Naomi Fukagawa and Makoto Saegusa
    Citation: BMC Cancer 2023 23:765
    Content type: Research Published on:

  39. Currently, there is no standard treatment for managing relapse in patients with acute myeloid leukemia and myelodysplastic syndrome (AML/MDS) after allogeneic hematopoietic cell transplantation. Venetoclax-bas...

    Authors: Yufeng Du, Chunhong Li, Zhijia Zhao, Yikun Liu, Chengtao Zhang and Jinsong Yan
    Citation: BMC Cancer 2023 23:764
    Content type: Research Published on:

  40. In the tumor microenvironment (TME), the dynamic interaction between tumor cells and immune cells plays a critical role in predicting the prognosis of colorectal cancer. This study introduces a novel approach ...

    Authors: Qicong Chen, Ming Cai, Xinjuan Fan, Wenbin Liu, Gang Fang, Su Yao, Yao Xu, Qian Li, Yingnan Zhao, Ke Zhao, Zaiyi Liu and Zhihua Chen
    Citation: BMC Cancer 2023 23:763
    Content type: Research Published on:

  41. Glioblastoma patients commonly develop resistance to temozolomide chemotherapy. Hypoxia, which supports chemotherapy resistance, favors the expansion of glioblastoma stem cells (GSC), contributing to tumor rel...

    Authors: Nadia Sousa, Carsten Geiß, Laura Bindila, Ingo Lieberwirth, Ella Kim and Anne Régnier-Vigouroux
    Citation: BMC Cancer 2023 23:762
    Content type: Research Published on:

  42. This study aims to evaluate the relationship between age, period, and birth cohort with the incidence trends of Nasopharyngeal Carcinoma (NPC) in Hong Kong, make projections through 2030 and parse the drivers ...

    Authors: Xiaoyan Wang, Haifeng Sun, Linchang Li, Zhenhai Gan, Xiaoming Wu and Jianqiang Du
    Citation: BMC Cancer 2023 23:761
    Content type: Research Published on:

  44. Lung cancer is reported to be the leading cause of death in males and females, globally. Increasing evidence highlights the paramount importance of Lactate dehydrogenase D (LDHD) in different types of cancers,...

    Authors: Yu Zhang, Tianyi Zhang, Yingdong Zhao, Hongdi Wu, Qiang Zhen, Suwei Zhu and Shaoshuai Hou
    Citation: BMC Cancer 2023 23:759
    Content type: Research Published on:

  45. Alcohol consumption has been associated with increased risks of certain site-specific cancers and decreased risks of some other cancers. There is, however, little reliable evidence as to whether the alcohol-as...

    Authors: Sarah Floud, Carol Hermon, Rachel F Simpson and Gillian K Reeves
    Citation: BMC Cancer 2023 23:758
    Content type: Research Published on:

  48. This project aimed to research the significance of THRIL in the diagnosis of benign and malignant solitary pulmonary nodules (SPNs) and to investigate the role of THRIL/miR-99a in malignant SPNs.

    Authors: Xinyu Chen, Xianji Zhu, Wenjun Yan, Luan Wang, Dongming Xue, Shouying Zhu, Jiajun Pan, Yufeng Li, Qixiang Zhao and Dong Han
    Citation: BMC Cancer 2023 23:755
    Content type: Research Published on:

  49. Spatial analysis can identify communities where men are at risk for aggressive prostate cancer (PCan) and need intervention. However, there are several definitions for aggressive PCan. In this study, we evalua...

    Authors: Daniel Wiese, Tesla D. DuBois, Kristen A. Sorice, Carolyn Y. Fang, Camille Ragin, Mary B. Daly, Adam C. Reese, Kevin A. Henry and Shannon M. Lynch
    Citation: BMC Cancer 2023 23:754
    Content type: Research Published on:

  50. An increasing amount of research has speculated that necroptosis could be a therapeutic strategy for treating cancer. However, understanding the prognostic value of the necroptosis-related long non-coding RNAs...

    Authors: Jianlan Liu, Binlin Luo, Pengpeng Zhang, Keyu Jiang, Zuoqiong Hou, Xiaojian Cao and Jian Tang
    Citation: BMC Cancer 2023 23:752
    Content type: Research Published on:

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