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  1. Content type: Research article

    Cancer is a genetic and epigenetic disease that involves inactivation of tumor suppressor genes and activation of proto-oncogenes. All-trans retinoic acid (ATRA) is an isomer of retinoic acid involved in the o...

    Authors: Lara Lima, Thaísa Cristina Tavares de Melo, Diego Marques, Jéssica Nayara Góes de Araújo, Isabela Samária Fernandes Leite, Camila Xavier Alves, Julieta Genre and Vivian Nogueira Silbiger

    Citation: BMC Cancer 2019 19:866

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  2. Content type: Research article

    This study aims to investigate the expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 in bulky cervical squamous carcinoma and its predictive role in cisplatin-based neoadjuvant chemotherapy.

    Authors: Haiyan Zhu, Xuejiao Tao, Lulu Zhou, Bo Sheng, Xuejie Zhu and Xueqiong Zhu

    Citation: BMC Cancer 2019 19:865

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  3. Content type: Research article

    Bronchial carcinoids are neuroendocrine tumors that present as typical (TC) and atypical (AC) variants, the latter being more aggressive, invasive and metastatic. Studies of tumor initiating cell (TIC) biology...

    Authors: Reza Bayat Mokhtari, Narges Baluch, Evgeniya Morgatskaya, Sushil Kumar, Angelo Sparaneo, Lucia Anna Muscarella, Sheyun Zhao, Hai-Ling Cheng, Bikul Das and Herman Yeger

    Citation: BMC Cancer 2019 19:864

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  4. Content type: Research article

    Most clinical trials on colorectal cancer (CRC) exclude cases who have history of a prior malignancy. However, no prior research studied this history’s actual impact on the survival of CRC. In the paper, we st...

    Authors: Muneer J. Al-Husseini, Anas M. Saad, Hadeer H. Mohamed, Mohamad A. Alkhayat, Mohamad Bassam Sonbol and Omar Abdel-Rahman

    Citation: BMC Cancer 2019 19:863

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  5. Content type: Research article

    Nested case-control studies examining the association between serum markers of chronic inflammation, focused on three specific biomarkers (CRP, IL-8 and TNF-α), and risk of pancreatic cancer have reported no a...

    Authors: Sam Sollie, Dominique S. Michaud, Debashis Sarker, Sophia N. Karagiannis, Debra H. Josephs, Niklas Hammar, Aida Santaolalla, Goran Walldius, Hans Garmo, Lars Holmberg, Ingmar Jungner and Mieke Van Hemelrijck

    Citation: BMC Cancer 2019 19:858

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  6. Content type: Research article

    Selecting the appropriate patients to receive immunotherapy (IO) remains a challenge due to the lack of optimal biomarkers. The presence of liver metastases has been implicated as a poor prognostic factor in p...

    Authors: Mehmet Asim Bilen, Julie M. Shabto, Dylan J. Martini, Yuan Liu, Colleen Lewis, Hannah Collins, Mehmet Akce, Haydn Kissick, Bradley C. Carthon, Walid L. Shaib, Olatunji B. Alese, Conor E. Steuer, Christina Wu, David H. Lawson, Ragini Kudchadkar, Viraj A. Master…

    Citation: BMC Cancer 2019 19:857

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  7. Content type: Research article

    To investigate the association between pre-diagnostic colonoscopy and colorectal cancer mortality in South Australia.

    Authors: Ming Li, Ian Olver, Dorothy Keefe, Carol Holden, Dan Worthley, Timothy Price, Christos Karapetis, Caroline Miller, Kate Powell, Dianne Buranyi-Trevarton, Kellie Fusco and David Roder

    Citation: BMC Cancer 2019 19:856

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  8. Content type: Study protocol

    Despite recent advances in the treatment of multiple myeloma, the disease constantly relapses and is still considered as incurable. The current knowledge about the biological mechanisms underlying resistance t...

    Authors: Lina Benaniba, Benoit Tessoulin, Sabrina Trudel, Catherine Pellat-Deceunynck, Martine Amiot, Stéphane Minvielle, Pierre Antoine Gourraud, Sophie de Visme, Hervé Maisonneuve, Anne Lok, Steven Le Gouill, Philippe Moreau and Cyrille Touzeau

    Citation: BMC Cancer 2019 19:855

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  9. Content type: Research article

    Lung cancer is the leading cause of cancer-related deaths worldwide. This study focuses on its most common form, Non-Small-Cell Lung Cancer (NSCLC). No cure exists for advanced NSCLC, and patient prognosis is ...

    Authors: Dania Movia, Despina Bazou and Adriele Prina-Mello

    Citation: BMC Cancer 2019 19:854

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  10. Content type: Correction

    Following publication of the original article [1], the authors reported the family name of the second author was incorrectly published.

    Authors: V. Doma, S. Kárpáti, E. Rásó, T. Barbai and J. Tímár

    Citation: BMC Cancer 2019 19:853

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    The original article was published in BMC Cancer 2019 19:786

  11. Content type: Research article

    Recently, evidence has emerged that palliative gastrectomy in patients with stage IV gastric cancer may offer some survival benefits. However, the decision whether to perform primary tumor surgery remains chal...

    Authors: Tai Ma, Zhi-jun Wu, Hui Xu, Chang-hao Wu, Jing Xu, Wan-ren Peng, Lu-lu Fan and Guo-ping Sun

    Citation: BMC Cancer 2019 19:852

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  12. Content type: Research article

    Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression. The stem cell pluripotent transcriptional factor SOX family play cri...

    Authors: Mei-Mei Li, Yun-Qiang Tang, Yuan-Feng Gong, Wei Cheng, Hao-Long Li, Fan-En Kong, Wen-Jie Zhu, Shan-Shan Liu, Li Huang, Xin-Yuan Guan, Ning-Fang Ma and Ming Liu

    Citation: BMC Cancer 2019 19:851

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  13. Content type: Research article

    In 2017, the New South Wales Cancer Registry (NSWCR) participated in a project, supported by Cancer Australia, aiming to provide national stage data for melanoma, prostate, colorectal, breast, and lung cancers...

    Authors: Sheena Lawrance, Chau Bui, Vidur Mahindra, Maria Arcorace and Claire Cooke-Yarborough

    Citation: BMC Cancer 2019 19:850

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  14. Content type: Research article

    Recent years have witnessed the rapid evolution of therapies in chronic-phase chronic myeloid leukemia (CP-CML). To assess the efficacy and tolerability of all reported front-line treatments for patients with ...

    Authors: Lu Tang, Huan Zhang, Yi-zhong Peng, Cheng-gong Li, Hui-wen Jiang, Min Xu, Heng Mei and Yu Hu

    Citation: BMC Cancer 2019 19:849

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  15. Content type: Research article

    Atypical teratoid/rhabdoid tumors (AT/RTs) are highly malignant brain tumors with inactivation of the SMARCB1 gene, which play a critical role in genomic transcriptional control. In this study, we analyzed the ge...

    Authors: Ji Hoon Phi, Choong-Hyun Sun, Se-Hoon Lee, Seungmook Lee, Inho Park, Seung Ah Choi, Sung-Hye Park, Ji Yeoun Lee, Kyu-Chang Wang, Seung-Ki Kim, Hongseok Yun and Chul-Kee Park

    Citation: BMC Cancer 2019 19:848

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  16. Content type: Research article

    Studies over the past 10 years strongly support an association between skeletal muscle mass (SMM) depletion and outcome in metastatic colorectal cancer (mCRC). Factors influencing SMM changes over time are, ho...

    Authors: Sami Antoun, Mohamed Amine Bayar, Valérie Dyevre, Emilie Lanoy, Cristina Smolenschi and Michel Ducreux

    Citation: BMC Cancer 2019 19:847

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  17. Content type: Research article

    To explore the association between biologically effective dose (BED) and survival rates in Child-Pugh A classification (CP-A) small hepatocellular carcinoma (HCC) patients treated with stereotactic body radiat...

    Authors: Jing Sun, Tao Zhang, Jia Wang, Wengang Li, Aimin Zhang, Weiping He, Dan Zhang, Dong Li, Junqiang Ding and Xuezhang Duan

    Citation: BMC Cancer 2019 19:846

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  18. Content type: Research article

    The rise in cervical cancer trends in the past two decades has coincided with the human immunodeficiency virus (HIV) epidemic especially in the sub-Saharan African region. Young people (15 to 24 years old) are...

    Authors: Witness Mapanga, Brendan Girdler-Brown and Elvira Singh

    Citation: BMC Cancer 2019 19:845

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  19. Content type: Case report

    The prognosis of ductal carcinoma in situ (DCIS) is reportedly well. Extremely rare patients with DCIS develop distant breast cancer metastasis without locoregional or contralateral recurrence. This is the fir...

    Authors: Qiuting You, Yichao Fang, Chenchen Li, Yujie Tan, Jianli Zhao, Cui Tan, Ying Wang, Herui Yao and Fengxi Su

    Citation: BMC Cancer 2019 19:844

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  20. Content type: Research article

    Recent studies reported that blood-based microRNAs (miRNAs) could detect cancers and predict prognosis have opened a new field of utilizing circulating miRNAs as cancer biomarkers. In this pilot study, we cond...

    Authors: Lirong Wu, Kexiao Zheng, Cheng Yan, Xuan Pan, Yatian Liu, Juying Liu, Feijiang Wang, Wenjie Guo, Xia He, Jiong Li and Ye Shen

    Citation: BMC Cancer 2019 19:843

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  21. Content type: Research article

    Helicobacter pylori (H. pylori) is thought to have an oncogenic effect on the development of gastric malignancies. However, the effect of H. pylori status on the prognosis of gastric diffuse large B-cell lymphoma...

    Authors: Yuan Cheng, Yinan Xiao, Ruofan Zhou, Yi Liao, Jing Zhou and Xuelei Ma

    Citation: BMC Cancer 2019 19:842

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  22. Content type: Research article

    Blood counting and the liver function tests, as the routine examinations, can reflect the immune and nutritional status of the body, our aim is to assess the prognostic significance of serum gamma-glutamyltran...

    Authors: Li-xiang Zhang, Yang Lv, A-Man Xu and Huan-zhong Wang

    Citation: BMC Cancer 2019 19:841

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  23. Content type: Research article

    Advanced stage laryngeal squamous cell carcinoma (LSCC) presents a poor prognosis; thus, there is a great need to identify novel prognostic molecular markers. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2...

    Authors: Xiaoli Sheng, Yunxian Li, Yixuan Li, Wenlin Liu, Zhongming Lu, Jiandong Zhan, Mimi Xu, Liangsi Chen, Xiaoning Luo, Gang Cai and Siyi Zhang

    Citation: BMC Cancer 2019 19:840

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  24. Content type: Research article

    Identification of specific needs in patients with cancer is very important for the provision of patient-centered medical service. The aim of this study was to investigate the unmet needs and related factors of...

    Authors: Byung Joo Chae, Jihyoun Lee, Se Kyung Lee, Hyuk-Jae Shin, So-Youn Jung, Jong Won Lee, Zisun Kim, Min Hyuk Lee, Juhyung Lee and Hyun Jo Youn

    Citation: BMC Cancer 2019 19:839

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  25. Content type: Research article

    Adrenal tumors in patients with previous/synchronous extra-adrenal malignancy are diverse and are a dilemma in clinical practice. This study investigated the differentiation of adrenal malignant and benign tum...

    Authors: Lei Tan, Yunlin Ye, Kanghua Xiao, Xuelian Xu, Haitao Liang, Fufu Zheng and Zike Qin

    Citation: BMC Cancer 2019 19:838

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  26. Content type: Research article

    The activity of MP1, a pyrrolomycin, was studied in MYCN amplified neuroblastoma (NB) alone and combined with temsirolimus (TEM).

    Authors: Timothy R. McGuire, Don W. Coulter, Dachang Bai, Jason A. Sughroue, Jerry Li, Zunhua Yang, Zhen Qiao, Yan Liu, Daryl J. Murry, Yashpal S. Chhonker, Erin M. McIntyre, Gracey Alexander, John G. Sharp and Rongshi Li

    Citation: BMC Cancer 2019 19:837

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  27. Content type: Research article

    Depression is a common co-morbid, disabling disorder that affects 10–25% of cancer patients. It causes substantial functional impairment and lowers survival rate of breast cancer patients. Therefore, the aim o...

    Authors: Abigiya Wondimagegnehu, Workeabeba Abebe, Aynalem Abraha and Solomon Teferra

    Citation: BMC Cancer 2019 19:836

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  28. Content type: Research article

    In the U.S., lung cancer accounts for 14% of cancer diagnoses and 28% of cancer deaths annually. Since no cure exists for advanced lung cancer, the main treatment goal is to prolong survival. Chemotherapy regi...

    Authors: K. M. Islam, T. Anggondowati, P. E. Deviany, J. E. Ryan, A. Fetrick, D. Bagenda, M. S. Copur, A. Tolentino, I. Vaziri, H. A. McKean, S. Dunder, J. E. Gray, C. Huang and A. K. Ganti

    Citation: BMC Cancer 2019 19:835

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  29. Content type: Research article

    Blood-based methods using cell-free DNA (cfDNA) are under development as an alternative to existing screening tests. However, early-stage detection of cancer using tumor-derived cfDNA has proven challenging be...

    Authors: Nathan Wan, David Weinberg, Tzu-Yu Liu, Katherine Niehaus, Eric A. Ariazi, Daniel Delubac, Ajay Kannan, Brandon White, Mitch Bailey, Marvin Bertin, Nathan Boley, Derek Bowen, James Cregg, Adam M. Drake, Riley Ennis, Signe Fransen…

    Citation: BMC Cancer 2019 19:832

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  30. Content type: Research article

    Metastasis is responsible for the majority of deaths in a variety of cancer types, including breast cancer. Although several factors or biomarkers have been identified to predict the outcome of patients with b...

    Authors: Liang Zeng, Xiyun Deng, Jingmin Zhong, Li Yuan, Xiaojun Tao, Sai Zhang, Yong Zeng, Guangchun He, Pingping Tan and Yongguang Tao

    Citation: BMC Cancer 2019 19:831

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  31. Content type: Research article

    The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit. Currently the...

    Authors: Fatima Qadir, Anand Lalli, Huma Habib Dar, Sungjae Hwang, Hebah Aldehlawi, Hong Ma, Haiyan Dai, Ahmad Waseem and Muy-Teck Teh

    Citation: BMC Cancer 2019 19:830

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  32. Content type: Research article

    Carbon ion (12C) radiotherapy is becoming very promising to kill highly metastatic cancer cells keeping adjacent normal cells least affected. Our previous study shows that combined PARP-1 inhibition with 12C ion ...

    Authors: Priyanka Chowdhury, Payel Dey, Sourav Ghosh, Asitikantha Sarma and Utpal Ghosh

    Citation: BMC Cancer 2019 19:829

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  33. Content type: Research article

    Sexuality is an important aspect of quality of life for adolescent and young adults that remains understudied in cancer patients. Most current knowledge about how cancer and cancer treatments can affect patien...

    Authors: Julian Mütsch, Michael Friedrich, Katja Leuteritz, Annekathrin Sender, Kristina Geue, Anja Hilbert and Yve Stöbel-Richter

    Citation: BMC Cancer 2019 19:828

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  34. Content type: Case report

    SMARCB1-deficient sinonasal carcinoma (SDSC) is an aggressive subtype of head and neck cancers that has a poor prognosis despite multimodal therapy. We present a unique case with next generation sequencing dat...

    Authors: Horacio Gomez-Acevedo, John D. Patterson, Sehrish Sardar, Murat Gokden, Bhaskar C. Das, David W. Ussery and Analiz Rodriguez

    Citation: BMC Cancer 2019 19:827

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  35. Content type: Research article

    Radiotherapy (RT) is considered an important therapeutic strategy in the fight against colorectal cancer (CRC). However, the existence of some radioresistance factors becomes the main challenge for the RT. Rec...

    Authors: Hongbin Li, Xiaodong Jin, Bingtao Liu, Pengcheng Zhang, Weiqiang Chen and Qiang Li

    Citation: BMC Cancer 2019 19:826

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  36. Content type: Research article

    To develop a new 18 high-risk human papillomavirus (HR HPV) detection and genotyping assay, which is important to evaluate the risk degree of HR HPV for causing cancers.

    Authors: Xushan Cai, Qinghua Guan, Yu Huan, Ziyu Liu, Jiehua Qi and Shichao Ge

    Citation: BMC Cancer 2019 19:825

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  37. Content type: Research article

    Genomic initiatives such as The Cancer Genome Atlas (TCGA) contain data from -omics profiling of thousands of tumor samples, which may be used to decipher cancer signaling, and related alterations. Managing an...

    Authors: Marta Lucchetta, Isabelle da Piedade, Mohamed Mounir, Marina Vabistsevits, Thilde Terkelsen and Elena Papaleo

    Citation: BMC Cancer 2019 19:824

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  38. Content type: Research article

    Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However...

    Authors: Seyedeh Raheleh Niavarani, Christine Lawson, Orneala Bakos, Marie Boudaud, Cory Batenchuk, Samuel Rouleau and Lee-Hwa Tai

    Citation: BMC Cancer 2019 19:823

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  39. Content type: Research article

    There is currently no evidence that hepatitis C virus (HCV) genotype affects survival in patients with hepatocellular carcinoma (HCC). This study aimed to investigate whether the HCV genotype affected the surv...

    Authors: Hye Kyong Park, Sang Soo Lee, Chang Bin Im, Changjo Im, Ra Ri Cha, Wan Soo Kim, Hyun Chin Cho, Jae Min Lee, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung and Ok-Jae Lee

    Citation: BMC Cancer 2019 19:822

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  40. Content type: Research article

    miR-182-5p (miR-182) is an oncogenic microRNA (miRNA) found in different tumor types and one of the most up-regulated miRNA in colorectal cancer (CRC). Although this microRNA is expressed in the early steps of...

    Authors: Lisa Perilli, Sofia Tessarollo, Laura Albertoni, Matteo Curtarello, Anna Pastò, Efrem Brunetti, Matteo Fassan, Massimo Rugge, Stefano Indraccolo, Alberto Amadori, Stefania Bortoluzzi and Paola Zanovello

    Citation: BMC Cancer 2019 19:821

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  41. Content type: Research article

    Progression of breast cancer involves both genetic and epigenetic factors. Parkin gene has been identified as a tumor suppressor gene in the pathogenesis of various cancers. Nevertheless, the putative role of Par...

    Authors: Khushnuma Wahabi, Ahmad Perwez, Shabeena Kamarudheen, Zafar Iqbal Bhat, Anurag Mehta and M. Moshahid A. Rizvi

    Citation: BMC Cancer 2019 19:820

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  42. Content type: Research article

    Treatment of acute myeloid leukemia (AML) in elderly patients remains a great challenge. In this prospective single arm study (ChiCTR-OPC-15006492), we evaluated the efficacy and safety of a novel consolidatio...

    Authors: Xiaoyang Li, Yuexin Dong, Ya Li, Ruibao Ren, Wen Wu, Hongming Zhu, Yunxiang Zhang, Jiong Hu and Junmin Li

    Citation: BMC Cancer 2019 19:819

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  43. Content type: Research article

    The aim of this study was to investigate the potential of cell-free DNA (cfDNA) as a disease biomarker in oesophageal squamous cell carcinoma (ESCC) that can be used for treatment response evaluation and early...

    Authors: Pei Meng, Jiacong Wei, Yiqun Geng, Shaobin Chen, Miente Martijn Terpstra, Qiongyi Huang, Qian Zhang, Zuoqing Su, Wanchun Yu, Min Su, Klaas Kok, Anke van den Berg and Jiang Gu

    Citation: BMC Cancer 2019 19:818

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  44. Content type: Research article

    Adoptive transfer of immune cells such as T cells and natural killer (NK) cells has emerged as a targeted method of controlling the immune system against cancer. Despite their significant therapeutic potential...

    Authors: Jung-Won Choi, Eui Soo Lee, Se Young Kim, Su Il Park, Sena Oh, Jung Hwa Kang, Hyun Aae Ryu and Seahyoung Lee

    Citation: BMC Cancer 2019 19:817

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  45. Content type: Study protocol

    Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellen...

    Authors: David A. Palma, Robert Olson, Stephen Harrow, Rohann J. M. Correa, Famke Schneiders, Cornelis J. A. Haasbeek, George B. Rodrigues, Michael Lock, Brian P. Yaremko, Glenn S. Bauman, Belal Ahmad, Devin Schellenberg, Mitchell Liu, Stewart Gaede, Joanna Laba, Liam Mulroy…

    Citation: BMC Cancer 2019 19:816

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  46. Content type: Research article

    Current advancements in neoadjuvant therapy and total mesorectal excision have engendered increased local control. However, the survival benefit of preoperative radiotherapy (RT; 5 × 5 Gy) in rectal cancer pat...

    Authors: Yi-Hung Kuo, Chia-Hsuan Lai, Cheng-Yi Huang, Chih-Jung Chen, Yun-Ching Huang, Wen-Shih Huang and Chih-Chien Chin

    Citation: BMC Cancer 2019 19:815

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  47. Content type: Research article

    Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby incr...

    Authors: Agnieszka Jezierska-Drutel, Shireen Attaran, Barbara L. Hopkins, John J. Skoko, Steven A. Rosenzweig and Carola A. Neumann

    Citation: BMC Cancer 2019 19:812

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