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  1. Breast cancer-related lymphedema (BCRL) is associated with extensive axillary dissection. Axillary lymph node dissection (ALND) based on breast lymphatics level (BLL) was proposed to minimize the surgical exte...

    Authors: Qianqian Yuan, Jinxuan Hou, Yukun He, Yiqian Liao, Lewei Zheng and Gaosong Wu

    Citation: BMC Cancer 2021 21:293

    Content type: Research article

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  2. Sequential monitoring of Wilms’ tumor gene 1 (WT1) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) could predict relapse in adult acute myeloid leukemia (AML). However, the prognostic role...

    Authors: Dao-Xing Deng, Juan-Juan Wen, Yi-Fei Cheng, Xiao-Hui Zhang, Lan-Ping Xu, Yu Wang, Chen-Hua Yan, Yu-Hong Chen, Huan Chen, Wei Han, Feng-Rong Wang, Jing-Zhi Wang, Ya-Zhen Qin, Kai-Yan Liu, Xiao-Jun Huang, Xiao-Su Zhao…

    Citation: BMC Cancer 2021 21:292

    Content type: Research article

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  3. Avapritinib, a potent inhibitor of KIT and platelet-derived growth factor receptor A (PDGFRA) tyrosine kinases, has demonstrated unprecedented clinical activity in PDGFRA D842V-mutant gastrointestinal stromal ...

    Authors: Margaret von Mehren, Michael C. Heinrich, Hongliang Shi, Sergio Iannazzo, Raymond Mankoski, Saša Dimitrijević, Gerard Hoehn, Silvia Chiroli and Suzanne George

    Citation: BMC Cancer 2021 21:291

    Content type: Research article

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  5. Cervical cancer is a gynecologic cancer type that develops in the cervix, accounting for 8% mortality of all female cancer patients. Infection with specific human papillomavirus (HPV) types is considered the m...

    Authors: Shahana Sharmin, Fatima Tuj Zohura, Md. Sajedul Islam, Anika Shimonty, Md. Abdullah-Al-Kamran Khan, Rehana Parveen, Foujia Sharmin, Chowdhury Rafiqul Ahsan, Abul Bashar Mir Md. Khademul Islam and Mahmuda Yasmin

    Citation: BMC Cancer 2021 21:289

    Content type: Research article

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  6. If the depth of gallbladder malignant tumor (GBMT) invasion is deeper than the subserosa (ss), cholecystectomy is insufficient. In past reports that used endoscopic ultrasonography (EUS) to diagnose the depth ...

    Authors: Mitsuru Sugimoto, Hiroki Irie, Mika Takasumi, Minami Hashimoto, Yuka Oka, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Jun Nakamura, Tsunetaka Kato, Ryoichiro Kobashi, Yuko Hashimoto, Shigeru Marubashi, Takuto Hikichi…

    Citation: BMC Cancer 2021 21:288

    Content type: Technical advance

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  7. While molecularly targeted therapies and immune checkpoint inhibitors have improved the prognosis of advanced melanoma, biomarkers are required to monitor drug responses. Circulating tumor cells (CTCs) are rel...

    Authors: Yukiko Kiniwa, Kenta Nakamura, Asuka Mikoshiba, Atsuko Ashida, Yasuyuki Akiyama, Atsushi Morimoto and Ryuhei Okuyama

    Citation: BMC Cancer 2021 21:287

    Content type: Research article

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  8. In this study, we investigated CD20+ TILs in triple-negative breast cancer (TNBC) and their relationship with T lymphocyte subsets (CD4+, CD8+, CD25+, and FOXP3+), including their combined prognostic value usi...

    Authors: Hajime Kuroda, Tsengelmaa Jamiyan, Rin Yamaguchi, Akinari Kakumoto, Akihito Abe, Oi Harada and Atsuko Masunaga

    Citation: BMC Cancer 2021 21:286

    Content type: Research article

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  9. Differentiating true glioblastoma multiforme (GBM) from pseudoprogression (PsP) remains a challenge with current standard magnetic resonance imaging (MRI). The objective of this study was to explore whether pa...

    Authors: Jing Xi, Bilal Hassan, Ruth G. N. Katumba, Karam Khaddour, Akshay Govindan, Jingqin Luo, Jiayi Huang and Jian L. Campian

    Citation: BMC Cancer 2021 21:285

    Content type: Research article

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  10. Circular RNAs (circRNAs) feature prominently in tumor progression. However, the biological function and molecular mechanism of circ_0003266 in colorectal cancer (CRC) require further investigation.

    Authors: Caihong Wen, Xiaoqing Feng, Honggang Yuan, Yong Gong and Guangsheng Wang

    Citation: BMC Cancer 2021 21:284

    Content type: Research article

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  11. The accurate prediction of post-hepatectomy early recurrence (PHER) of hepatocellular carcinoma (HCC) is vital in determining postoperative adjuvant treatment and monitoring. This study aimed to develop and va...

    Authors: Rong-yun Mai, Jie Zeng, Wei-da Meng, Hua-ze Lu, Rong Liang, Yan Lin, Guo-bin Wu, Le-qun Li, Liang Ma, Jia-zhou Ye and Tao Bai

    Citation: BMC Cancer 2021 21:283

    Content type: Research article

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  12. Mismatch repair (MMR)/microsatellite instability (MSI) and tumor mutational burden (TMB) are independent biomarkers that complement each other for predicting immune checkpoint inhibitors (ICIs) efficacy. Here ...

    Authors: Jian Xiao, Wenyun Li, Yan Huang, Mengli Huang, Shanshan Li, Xiaohui Zhai, Jing Zhao, Chan Gao, Wenzhuan Xie, Hao Qin, Shangli Cai, Yuezong Bai, Ping Lan and Yifeng Zou

    Citation: BMC Cancer 2021 21:282

    Content type: Research article

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  13. Cervical cancer is the fourth cancer worldwide. The Human Papilloma Virus is responsible for 99% of the cases but the distribution of its genotypes varies among populations. We aimed to identify HPV genotypes ...

    Authors: Stanie Gaete, Aviane Auguste, Bernard Bhakkan, Jessica Peruvien, Cecile Herrmann-Storck, Youri Socrier, Abdoulaye Diedhiou and Jacqueline Deloumeaux

    Citation: BMC Cancer 2021 21:281

    Content type: Research article

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  14. Although criteria for liver transplantation, such as the Milan criteria and Hangzhou experiences, have become popular, criteria to guide adjuvant therapy for patients with hepatocellular carcinoma after liver ...

    Authors: Dabing Huang, Yinan Shen, Wei Zhang, Chengxiang Guo, Tingbo Liang and Xueli Bai

    Citation: BMC Cancer 2021 21:280

    Content type: Research article

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  15. Thymic tumors are unusual neoplasms, representing 0.2 to 1.5% of tumors in humans, but correspond to 20% of mediastinal tumors and 50% of those that occur in the anterior mediastinum. They tend to appear aroun...

    Authors: Diego F. Scarpetta-Gonzalez, Eliana Isabel Morales, Luz Fernanda Sua, Mauricio Velásquez, Saveria Sangiovanni and Liliana Fernández-Trujillo

    Citation: BMC Cancer 2021 21:279

    Content type: Research article

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  18. Cancer stem cells are important for the development of many solid tumors. These cells receive promoting and inhibitory signals that depend on the nature of their environment (their niche) and determine cell dy...

    Authors: Lucía Benítez, Lucas Barberis, Luciano Vellón and Carlos A. Condat

    Citation: BMC Cancer 2021 21:276

    Content type: Research article

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  19. Dysregulated miRNAs are involved in carcinogenesis of the breast and may be used as prognostic biomarkers and therapeutic targets during the cancer process. The purpose of this study was to explore the effect ...

    Authors: Bo Lin, Chunhua Liu, Enyi Shi, Qiu Jin, Wenhui Zhao, Juan Wang and Runyuan Ji

    Citation: BMC Cancer 2021 21:275

    Content type: Research article

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  20. We aimed to study the mortality and intensity of health care in patients with advanced lung cancer who received systemic anti-cancer treatment (SACT) compared with patients who were not eligible for SACT (no-S...

    Authors: Kersti Oselin, Heti Pisarev, Keit Ilau and Raul-Allan Kiivet

    Citation: BMC Cancer 2021 21:274

    Content type: Research article

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  21. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12885-016-2277-2.

    Authors: Zhen Liu, Chao Cheng, Xiaojun Luo, Qiong Xia, Yejie Zhang, Xiaobing Long, Qingping Jiang and Weiyi Fang

    Citation: BMC Cancer 2021 21:273

    Content type: Retraction Note

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    The original article was published in BMC Cancer 2016 16:238

  22. Bile duct invasion is a relatively rare event and is not well characterised in hepatocellular carcinoma (HCC). It remains very difficult to diagnose HCC with bile duct tumour thrombus (BDTT) before surgery. In...

    Authors: Jun-Yi Wu, Ju-Xian Sun, Jia-Yi Wu, Xiao-Xiao Huang, Yan-Nan Bai, Yong-Yi Zeng, Zhi-Bo Zhang, Shu-Qun Cheng and Mao-Lin Yan

    Citation: BMC Cancer 2021 21:272

    Content type: Research article

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  23. Childhood cancer is one of the leading causes of morbidity and mortality in the pediatrics age group. The problem affects both developed and developing countries. A high mortality rate has been observed in low...

    Authors: Aklilu Endalamaw, Nega Tezera Assimamaw, Tadesse Awoke Ayele, Achenef Asmamaw Muche, Ejigu Gebeye Zeleke, Amare Wondim, Getaneh Mulualem Belay, Yeneabat Birhanu, Ashenafi Tazebew, Masresha Asmare Techane, Selam Fisha Kassa and Chalachew Adugna Wubneh

    Citation: BMC Cancer 2021 21:271

    Content type: Research article

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  24. Epidermal growth factor receptor (EGFR) is a target for cancer therapy as it is overexpressed in a wide variety of cancers. Therapeutic antibodies that bind EGFR are being evaluated in clinical trials as imagi...

    Authors: Wendy Bernhard, Kris Barreto, Ayman El-Sayed, Carolina Gonzalez, Raja Solomon Viswas, Darien Toledo, Angel Casaco, John DeCoteau, Humphrey Fonge and Clarence Ronald Geyer

    Citation: BMC Cancer 2021 21:270

    Content type: Research article

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  27. The objective of the study was to detect the expression of Kita-Kyushu lung cancer antigen-1 (KK-LC-1) in gastric cancer (GC) specimens and analyse the associations between KK-LC-1 expression and clinicopathol...

    Authors: Jun Ji, Jiahui Chen, Anqiang Wang, Wei Zhang, Hongge Ju, Yang Liu and Leping Li

    Citation: BMC Cancer 2021 21:267

    Content type: Research article

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  28. To explore possible solutions to overcome chronic Bacillus Calmette–Guérin (BCG) shortage affecting seriously the management of non-muscle invasive bladder cancer (NMIBC) in Europe and throughout the world, we...

    Authors: Makito Miyake, Kota Iida, Nobutaka Nishimura, Tatsuki Miyamoto, Kiyohide Fujimoto, Ryotaro Tomida, Kazumasa Matsumoto, Kazuyuki Numakura, Junichi Inokuchi, Shuichi Morizane, Takahiro Yoneyama, Yoshiaki Matsumura, Takashige Abe, Masaharu Inoue, Takeshi Yamada, Naoki Terada…

    Citation: BMC Cancer 2021 21:266

    Content type: Research article

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  29. Gliosarcoma (GSM) is a distinct and aggressive variant of glioblastoma multiforme (GBM) with worse prognosis and few treatment options. It is often managed with the same treatment modalities with temozolomide ...

    Authors: Karrie Mei-Yee Kiang, Andrian A. Chan and Gilberto Ka-Kit Leung

    Citation: BMC Cancer 2021 21:265

    Content type: Research article

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  30. Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagno...

    Authors: Akira Sato, Keisuke Matsubayashi, Toshitaka Morishima, Kayo Nakata, Koji Kawakami and Isao Miyashiro

    Citation: BMC Cancer 2021 21:264

    Content type: Research article

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  31. Lung cancer remains the leading cause of cancer deaths across the world. Early detection of lung cancer by low-dose computed tomography (LDCT) can reduce the mortality rate. However, making a definitive preope...

    Authors: Wenqun Xing, Haibo Sun, Chi Yan, Chengzhi Zhao, Dongqing Wang, Mingming Li and Jie Ma

    Citation: BMC Cancer 2021 21:263

    Content type: Research article

    Published on:

  32. Probe electrospray ionization-mass spectrometry (PESI-MS) can rapidly visualize mass spectra of small, surgically obtained tissue samples, and is a promising novel diagnostic tool when combined with machine le...

    Authors: Sho Kiritani, Kentaro Yoshimura, Junichi Arita, Takashi Kokudo, Hiroyuki Hakoda, Meguri Tanimoto, Takeaki Ishizawa, Nobuhisa Akamatsu, Junichi Kaneko, Sen Takeda and Kiyoshi Hasegawa

    Citation: BMC Cancer 2021 21:262

    Content type: Research article

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  33. To investigate the beam complexity and monitor unit (MU) efficiency issues for two different volumetric modulated arc therapy (VMAT) delivery technologies for patients with left-sided breast cancer (BC) and na...

    Authors: Chengqiang Li, Cheng Tao, Tong Bai, Zhenjiang Li, Ying Tong, Jian Zhu, Yong Yin and Jie Lu

    Citation: BMC Cancer 2021 21:261

    Content type: Research article

    Published on:

  34. Tumor microenvironment (TME) is a dynamic setting and changes in TILs and their subpopulations are potential candidates to influence the metastatic process. Aim of this pilot study is to describe the changes o...

    Authors: Annalisa Zeppellini, Stefania Galimberti, Biagio Eugenio Leone, Claudia Pacifico, Francesca Riva, Federica Cicchiello, Serena Capici, Claudia Maggioni, Luca Sala and Marina Elena Cazzaniga

    Citation: BMC Cancer 2021 21:260

    Content type: Research article

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  35. The incidence and mortality of lung cancer are the highest among all cancers. Patients with systemic sclerosis show a four-fold greater risk of lung cancer than the general population. However, the underlying ...

    Authors: Heng Li, Liping Ding, Xiaoping Hong, Yulan Chen, Rui Liao, Tingting Wang, Shuhui Meng, Zhenyou Jiang and Dongzhou Liu

    Citation: BMC Cancer 2021 21:259

    Content type: Research article

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  36. The aim of this study was to investigate the relationship between multiple metabolism parameters derived from FDG and tumor TNM stages as well as tumor metastasis-associated protein of GLUT-1 and MACC1 in colo...

    Authors: Mingyu Zhang, Jigang Yang, Hao Jiang, Huijie Jiang and Zhenchang Wang

    Citation: BMC Cancer 2021 21:258

    Content type: Research article

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  37. Lung adenocarcinoma (LUAD) is the most frequently diagnosed histological subtype of lung cancer. Our purpose was to explore molecular subtypes and core genes for LUAD using multi-omics analysis.

    Authors: Yue Zhao, Yakun Gao, Xiaodong Xu, Jiwu Zhou and He Wang

    Citation: BMC Cancer 2021 21:257

    Content type: Research article

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  38. Head and neck cancers are aggressive cancers, most clinical studies focused on the prognosis of patients with head and neck cancer. However, perioperative mortality was rarely mentioned.

    Authors: Yannan Wang, Mengxue Wang, Yan Tang, Bincan Sun, Kai Wang and Feiya Zhu

    Citation: BMC Cancer 2021 21:256

    Content type: Research article

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  39. Competing endogenous RNA (ceRNA) represents a class of RNAs (e.g., long noncoding RNAs [lncRNAs]) with microRNA (miRNA) binding sites, which can competitively bind miRNA and inhibit its regulation of target ge...

    Authors: Jingyi Chen, Yuxuan Song, Mei Li, Yu Zhang, Tingru Lin, Jie Sun, Di Wang, Yulan Liu, Jingzhu Guo and Weidong Yu

    Citation: BMC Cancer 2021 21:255

    Content type: Research article

    Published on:

  40. Alcohol consumption is a major risk factor for esophageal cancer; however, a high incidence of esophageal cancer is observed particularly among Eastern Asians, although they consume relatively less alcohol, pr...

    Authors: Chang Kyun Choi, Jungho Yang, Sun-Seog Kweon, Sang-Hee Cho, Hye-Yeon Kim, Eun Myung and Min-Ho Shin

    Citation: BMC Cancer 2021 21:254

    Content type: Research article

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  41. The liver is one of the most frequent sites of metastases in rectal cancer. This study aimed to evaluate how the development of synchronous or metachronous liver metastasis and overall survival are impacted by...

    Authors: Giulia Besutti, Angela Damato, Francesco Venturelli, Candida Bonelli, Massimo Vicentini, Filippo Monelli, Pamela Mancuso, Guido Ligabue, Pierpaolo Pattacini, Carmine Pinto and Paolo Giorgi Rossi

    Citation: BMC Cancer 2021 21:253

    Content type: Research article

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  42. Diacylglycerol-acyltransferase 1 (DGAT1) plays an important role in the energy storage and is involved in cancer progression. A growing number of evidences showed that elevated expression of DGAT1 in cancer tissu...

    Authors: Ping He, Shihuan Cheng, Feng Hu, Zhanchuan Ma and Yan Xia

    Citation: BMC Cancer 2021 21:252

    Content type: Research article

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  44. We quantified the elusive effects of putative factors on the clinical course of early hepatocellular carcinoma (HCC) after primary surgical or nonsurgical curative treatment.

    Authors: Ming-Jeng Kuo, Lein-Ray Mo and Chi-Ling Chen

    Citation: BMC Cancer 2021 21:250

    Content type: Research article

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  45. The current standard postoperative treatment for stage II-IIIA non-small cell lung cancer (NSCLC) is a regimen of platinum doublet adjuvant chemotherapy. These regimens, which are the same as for solid NSCLC t...

    Authors: Tomoshi Tsuchiya, Keitaro Matsumoto, Takuro Miyazaki, Ryoichiro Doi, Shoji Tokunaga, Hiroyuki Yamaguchi, Koichi Tomoshige, Hironosuke Watanabe, Takeshi Nagayasu and Kenji Sugio

    Citation: BMC Cancer 2021 21:249

    Content type: Study protocol

    Published on:

  46. Low-grade glioma (LGG) is a relatively rare type of brain tumour. The use of antidepressant, sedative and anti-epileptic drugs can reflect the burden of the disease. While epilepsy is well-described in patient...

    Authors: Isabelle Rydén, Erik Thurin, Louise Carstam, Anja Smits, Sasha Gulati, Roger Henriksson, Øyvind Salvesen and Asgeir Store Jakola

    Citation: BMC Cancer 2021 21:248

    Content type: Research article

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  47. Alpha-fetoprotein-negative hepatocellular carcinoma (AFP-NHCC) (< 8.78 ng/mL) have special clinicopathologic characteristics and prognosis. The aim of this study was to apply a new method to establish and vali...

    Authors: Dongdong Zhou, Xiaoli Liu, Xinhui Wang, Fengna Yan, Peng Wang, Huiwen Yan, Yuyong Jiang and Zhiyun Yang

    Citation: BMC Cancer 2021 21:246

    Content type: Research article

    Published on:

  48. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Dearbhaile Catherine Collins, Raghav Sundar, Anastasia Constantinidou, David Dolling, Timothy Anthony Yap, Sanjay Popat, Mary E. O’Brien, Udai Banerji, Johann Sebastian de Bono, Juanita Suzanne Lopez, Nina Tunariu and Anna Minchom

    Citation: BMC Cancer 2021 21:245

    Content type: Correction

    Published on:

    The original article was published in BMC Cancer 2020 20:1210

  50. It is very important to accurately delineate the CTV on the patient’s three-dimensional CT image in the radiotherapy process. Limited to the scarcity of clinical samples and the difficulty of automatic delinea...

    Authors: Zhongjian Ju, Wen Guo, Shanshan Gu, Jin Zhou, Wei Yang, Xiaohu Cong, Xiangkun Dai, Hong Quan, Jie Liu, Baolin Qu and Guocai Liu

    Citation: BMC Cancer 2021 21:243

    Content type: Research article

    Published on:

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