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  1. We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared ...

    Authors: Sanjay Sharma, Michael H Neale, Federica Di Nicolantonio, Louise A Knight, Pauline A Whitehouse, Stuart J Mercer, Bernard R Higgins, Alan Lamont, Richard Osborne, Andrew C Hindley, Christian M Kurbacher and Ian A Cree

    Citation: BMC Cancer 2003 3:19

    Content type: Research article

    Published on:

  2. Breast and cervical cancer continue to represent major health challenges for African American women. among Caucasian women. The underlying reasons for this disparity are multifactorial and include lack of educ...

    Authors: Thelma C Hurd, Paola Muti, Deborah O Erwin and Sharita Womack

    Citation: BMC Cancer 2003 3:18

    Content type: Research article

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  3. To determine whether the dose-volume histograms (DVH's) for the rectum and bladder constructed using biological-effective dose (BED-DVH's) better correlate with late gastrointestinal (GI) and genitourinary (GU...

    Authors: Ashesh B Jani, Christopher M Hand, Charles A Pelizzari, John C Roeske, Lani Krauz and Srinivasan Vijayakumar

    Citation: BMC Cancer 2003 3:16

    Content type: Research article

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  4. MART-1, Melan-A, and Tyrosinase have shown encouraging results for evaluation of melanoma micrometastases in sentinel lymph nodes, as compared to conventionally used S-100 protein and HMB-45. To achieve higher...

    Authors: Vinod B Shidham, Dan Qi, R Nagarjun Rao, Scott M Acker, Chung-Che Chang, Bal Kampalath, Glen Dawson, Jinobya K Machhi and Richard A Komorowski

    Citation: BMC Cancer 2003 3:15

    Content type: Research article

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  5. This study assesses whether comparatively high prostate cancer incidence rates among white men in Utah represent higher rates among members of the Church of Jesus Christ of Latter-day Saints (LDS or Mormons), ...

    Authors: Ray M Merrill, Sterling C Hilton, Charles L Wiggins and Jared D Sturgeon

    Citation: BMC Cancer 2003 3:14

    Content type: Research article

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  6. Both phenotypic and cytogenetic variability have been reported for clones of breast carcinoma cell lines but have not been comprehensively studied. Despite this, cell lines such as MCF-7 cells are extensively ...

    Authors: Mélanie Nugoli, Paul Chuchana, Julie Vendrell, Béatrice Orsetti, Lisa Ursule, Catherine Nguyen, Daniel Birnbaum, Emmanuel JP Douzery, Pascale Cohen and Charles Theillet

    Citation: BMC Cancer 2003 3:13

    Content type: Research article

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  7. The evaluation of cancer patients needs, especially during that delicate period when they are hospitalized, allows the identification of those areas of care that require to be improved. Aims of the study were ...

    Authors: Marcello Tamburini, Laura Gangeri, Cinzia Brunelli, Paolo Boeri, Claudia Borreani, Marco Bosisio, Claude Fusco Karmann, Margherita Greco, Guido Miccinesi, Luciana Murru and Patrizia Trimigno

    Citation: BMC Cancer 2003 3:12

    Content type: Research article

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  8. Recent observations indicate that human tumorous breast tissue metabolizes progesterone differently than nontumorous breast tissue. Specifically, 5α-reduced metabolites (5α-pregnanes, shown to stimulate cell p...

    Authors: John P Wiebe and Michael J Lewis

    Citation: BMC Cancer 2003 3:9

    Content type: Research article

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  9. Uterine cervix carcinoma is the second most common female malignancy worldwide and a major health problem in Mexico, representing the primary cause of death among the Mexican female population. High risk human...

    Authors: Alfredo Hidalgo, Alberto Monroy, Rosa Ma Arana, Lucía Taja, Guelaguetza Vázquez and Mauricio Salcedo

    Citation: BMC Cancer 2003 3:8

    Content type: Research article

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  10. Kaposi's Sarcoma (KS) is a proliferation of aberrant vascular structures lined by spindle cells, and is caused by a gammaherpes virus (HHV8/KSHV). Its course is aggravated by co-infection with HIV-1, where the...

    Authors: Marion Cornelissen, Antoinette C van der Kuyl, Remco van den Burg, Fokla Zorgdrager, Carel JM van Noesel and Jaap Goudsmit

    Citation: BMC Cancer 2003 3:7

    Content type: Research article

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  11. RAD54L (OMIM 603615, Locus Link 8438) has been proposed as a candidate oncosupressor in tumours bearing a non-random deletion of 1p32, such as breast or colon carcinomas, lymphomas and meningiomas. In a search f...

    Authors: Paola E Leone, Marta Mendiola, Javier Alonso, César Paz-y-Miño and Angel Pestaña

    Citation: BMC Cancer 2003 3:6

    Content type: Research article

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  12. Although colorectal cancer death rates have been declining, this trend is not consistent across all ethnic groups. Biological, environmental, behavioral and socioeconomic explanations exist, but the reason for...

    Authors: Ian S Pagano, Shane Y Morita, Sanjaya Dhakal, Scott A Hundahl and Gertraud Maskarinec

    Citation: BMC Cancer 2003 3:5

    Content type: Research article

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  13. The mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) encodes for a multifunctional receptor involved in lysosomal enzyme trafficking, fetal organogenesis, cytotoxic T cell-induced apoptosis a...

    Authors: Timothy A Jamieson, David M Brizel, J Keith Killian, Yoshihiko Oka, Hong-Seok Jang, Xiaolong Fu, Robert W Clough, Robin T Vollmer, Mitchell S Anscher and Randy L Jirtle

    Citation: BMC Cancer 2003 3:4

    Content type: Research article

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  14. Microarray-based gene expression profiling is a powerful approach for the identification of molecular biomarkers of disease, particularly in human cancers. Utility of this approach to measure responses to ther...

    Authors: Samuel E DePrimo, Lily M Wong, Deepak B Khatry, Susan L Nicholas, William C Manning, Beverly D Smolich, Anne-Marie O'Farrell and Julie M Cherrington

    Citation: BMC Cancer 2003 3:3

    Content type: Research article

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  15. Many tumours undergo disregulation of polyamine homeostasis and upregulation of ornithine decarboxylase (ODC) activity, which can promote carcinogenesis. In animal models of colon carcinogenesis, inhibition of...

    Authors: E Ann Hudson, Lynne M Howells, Barbara Gallacher-Horley, Louise H Fox, Andreas Gescher and Margaret M Manson

    Citation: BMC Cancer 2003 3:2

    Content type: Research article

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  16. Although new endoscopic techniques can enhance the ability to detect a suspicious lung lesion, the primary diagnosis still depends on subjective visual assessment. We evaluated whether thermal heterogeneity of...

    Authors: Christodoulos Stefanadis, Christina Chrysohoou, Demosthenes B Panagiotakos, Elisabeth Passalidou, Vasiliki Katsi, Vlassios Polychronopoulos and Pavlos K Toutouzas

    Citation: BMC Cancer 2003 3:1

    Content type: Research article

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  17. Mortality estimates alone are not sufficient to understand the true magnitude of cancer burden. We present the detailed estimates of mortality and incidence by site as the basis for the future estimation of ca...

    Authors: Kenji Shibuya, Colin D Mathers, Cynthia Boschi-Pinto, Alan D Lopez and Christopher JL Murray

    Citation: BMC Cancer 2002 2:37

    Content type: Research article

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    The Erratum to this article has been published in BMC Cancer 2003 3:20

  18. The Global Burden of Disease 2000 (GBD 2000) study starts from an analysis of the overall mortality envelope in order to ensure that the cause-specific estimates add to the total all cause mortality by age and...

    Authors: Colin D Mathers, Kenji Shibuya, Cynthia Boschi-Pinto, Alan D Lopez and Christopher JL Murray

    Citation: BMC Cancer 2002 2:36

    Content type: Research article

    Published on:

  19. Sodium/iodide symporter (NIS) is a key protein in iodide transport by thyroid cells and this activity is a prerequisite for effective radioiodide treatment of thyroid cancer. In the majority of thyroid cancers...

    Authors: Eusebio Chiefari, Antonio Brunetti, Franco Arturi, Jean-Michel Bidart, Diego Russo, Martin Schlumberger and Sebastiano Filetti

    Citation: BMC Cancer 2002 2:35

    Content type: Research article

    Published on:

  20. A number of osteoblastic meningiomas, primary osteosarcomas of the meninges, and post-radiation osteosarcomas of the head have been reported. However, postradiation dedifferentiation of meningioma into osteosa...

    Authors: Vladimir Osipov, Khang-Che Ho, Hendrikus G Krouwer, Glenn Meyer and Vinod B Shidham

    Citation: BMC Cancer 2002 2:34

    Content type: Case report

    Published on:

  21. Medulloblastomas, embryonal tumors arising in the cerebellum, commonly contain mutations that activate Wnt signaling. To determine whether increased Wnt signaling in the adult CNS is sufficient to induce tumor...

    Authors: John E Kratz, Duncan Stearns, David L Huso, Hilda H Slunt, Donald L Price, David R Borchelt and Charles G Eberhart

    Citation: BMC Cancer 2002 2:33

    Content type: Research article

    Published on:

  22. The activity of the ribonucleoprotein enzyme telomerase is detectable in germ, stem and tumor cells. One major component of telomerase is human telomerase reverse transcriptase (hTERT), which encodes the catal...

    Authors: Mark Schrader, Angelika M Burger, Markus Müller, Hans Krause, Bernd Straub, Martin Schostak, Wolfgang Schulze, Heidrun Lauke and Kurt Miller

    Citation: BMC Cancer 2002 2:32

    Content type: Research article

    Published on:

  23. Although a large number of epidemiological studies have examined the role of aspirin in the chemoprevention of colon cancer and other solid tumors, there is a limited body of research focusing on the associati...

    Authors: Kirsten B Moysich, Ravi J Menezes, Adrienne Ronsani, Helen Swede, Mary E Reid, K Michael Cummings, Karen L Falkner, Gregory M Loewen and Gerold Bepler

    Citation: BMC Cancer 2002 2:31

    Content type: Research article

    Published on:

  24. Hepatocellular carcinoma (HCC) presents one of the major health threats in China today. A better understanding of the molecular genetics underlying malignant transformation of hepatocytes is critical to succes...

    Authors: Jian Yu, Min Ni, Jian Xu, Hongyu Zhang, Baomei Gao, Jianren Gu, Jianguo Chen, Lisheng Zhang, Mengchao Wu, Sushen Zhen and Jingde Zhu

    Citation: BMC Cancer 2002 2:29

    Content type: Research article

    Published on:

  25. Psoriasin has been identified as a gene that is highly expressed in pre-invasive breast cancer, but is often downregulated with breast cancer progression. It is currently unknown whether psoriasin influences e...

    Authors: Ethan D Emberley, R Daniel Gietz, J Darren Campbell, Kent T HayGlass, Leigh C Murphy and Peter H Watson

    Citation: BMC Cancer 2002 2:28

    Content type: Research article

    Published on:

  26. In cervical tumours the integration of human papilloma viruses (HPV) transcripts often results in the generation of transcripts that consist of hybrids of viral and cellular sequences. Mapping data using a var...

    Authors: Eugene Klimov, Svetlana Vinokourova, Elena Moisjak, Elian Rakhmanaliev, Vera Kobseva, Laimonis Laimins, Fjodor Kisseljov and Galina Sulimova

    Citation: BMC Cancer 2002 2:24

    Content type: Research article

    Published on:

  27. This study was designed to evaluate if erythropoietin (EPO) is effective in the treatment of cancer related anemia, and if its effect remains unchanged when data are analyzed according to various clinical and ...

    Authors: Otavio Clark, Jared R Adams, Charles L Bennett and Benjamin Djulbegovic

    Citation: BMC Cancer 2002 2:23

    Content type: Research article

    Published on:

  28. Drugs & used in anticancer chemotherapy have severe effects upon the cellular transcription and replication machinery. From in vitro studies it has become clear that these drugs can affect specific genes, as well...

    Authors: Antoinette C van der Kuyl, Remco van den Burg, Fokla Zorgdrager, John T Dekker, Jolanda Maas, Carel JM van Noesel, Jaap Goudsmit and Marion Cornelissen

    Citation: BMC Cancer 2002 2:21

    Content type: Research article

    Published on:

  29. Loss or mutation of the mannose 6-phosphate/insulin-like growth factor-II receptor (M6P/IGF2R) has been found in breast cancer. However, whether or not decreased levels of functional M6P/IGF2R directly contrib...

    Authors: Zhihong Chen, Yinlin Ge, Natalie Landman and Jing X Kang

    Citation: BMC Cancer 2002 2:18

    Content type: Research article

    Published on:

  30. Modulation of the expression of retinoic acid receptors (RAR) α and γ in adult rat prostate by testosterone (T) suggests that RAR signaling events might mediate some of the androgen effects on prostate cells.

    Authors: Ming-tang Li, Frank Richter, Chawnshang Chang, Robert J Irwin and Hosea FS Huang

    Citation: BMC Cancer 2002 2:16

    Content type: Research article

    Published on:

  31. Phosphatidylinositol-3,4,5-triphosphate (PtdInsP3) signaling is elevated in many tumors due to loss of the tumor suppressor PTEN, and leads to constitutive activation of Akt, a kinase involved in cell survival...

    Authors: B Lynn Seely, Goli Samimi and Nicholas JG Webster

    Citation: BMC Cancer 2002 2:15

    Content type: Research article

    Published on:

  32. Immunomagnetic enrichment followed by RT-PCR (immunobead RT-PCR) is an efficient methodology to identify disseminated carcinoma cells in the blood and bone marrow. The RT-PCR assays must be both specific for t...

    Authors: Michael Raynor, Sally-Anne Stephenson, David CA Walsh, Kenneth B Pittman and Alexander Dobrovic

    Citation: BMC Cancer 2002 2:14

    Content type: Research article

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  33. Surgical treatment of hypopharyngeal cancers with extension to the retrocricoid region generally requires a circumferential pharyngolaryngectomy followed by a reconstruction of the removed segment of the upper...

    Authors: Marco Benazzo, Antonio Occhini, Vanessa Rossi, Giuseppe Aresi and Mario Alessiani

    Citation: BMC Cancer 2002 2:13

    Content type: Research article

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  34. The timed-sequential chemotherapy regimen consisting of etoposide, mitoxantrone and cytarabine (EMA) is an effective therapy for relapsed or refractory acute myelogenous leukemia (AML). We postulated that gran...

    Authors: Xing-Yue He, Paul Elson, Brad Pohlman, Alan Lichtin, Mohamad Hussein, Steve Andresen and Matt Kalaycio

    Citation: BMC Cancer 2002 2:12

    Content type: Research article

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  35. 5-fluorouracil remains the standard therapy for patients with advanced/metastatic colorectal cancer. Pre-clinical studies have demonstrated the biological modulation of 5-fluorouracil by methotrexate and leuco...

    Authors: Shannon K Tomlinson, Susan A Melin, Vetta Higgs, Douglas R White, Paul Savage, Douglas Case and A William Blackstock

    Citation: BMC Cancer 2002 2:9

    Content type: Research article

    Published on:

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