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  1. Published prognostic gene signatures in breast cancer have few genes in common. Here we provide a rationale for this observation by studying the prognostic power and the underlying biological pathways of diffe...

    Authors: Jack X Yu, Anieta M Sieuwerts, Yi Zhang, John WM Martens, Marcel Smid, Jan GM Klijn, Yixin Wang and John A Foekens

    Citation: BMC Cancer 2007 7:182

    Content type: Research article

    Published on:

  2. The sex hormone estrogen (E2) is pivotal to normal mammary gland growth and differentiation and in breast carcinogenesis. In this in silico study, we examined metabolic differences between ER(+)ve breast cancer c...

    Authors: Soma Mandal and James R Davie

    Citation: BMC Cancer 2007 7:181

    Content type: Research article

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  3. Feline mammary carcinoma has been proposed as a natural model of highly aggressive, hormone-independent human breast cancer. To further explore the utility of the model by adding new similarities between the t...

    Authors: Javier Ordás, Yolanda Millán, Rafaela Dios, Carlos Reymundo and Juana Martín de las Mulas

    Citation: BMC Cancer 2007 7:179

    Content type: Research article

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  4. For patients suffering of recurrent breast cancer within the irradiated breast, generally mastectomy is recommended. The normal tissue tolerance does not permit a second full-dose course of radiotherapy to the...

    Authors: Uta Kraus-Tiefenbacher, Lelia Bauer, Antonella Scheda, Carola Schoeber, Joerg Schaefer, Volker Steil and Frederik Wenz

    Citation: BMC Cancer 2007 7:178

    Content type: Research article

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  5. The present study evaluates the outcome of 19 children with rhabdomyosarcoma of the head-and-neck region treated with Intensity Modulated Radiotherapy (IMRT) or Fractionated Stereotactic Radiotherapy (FSRT) be...

    Authors: Stephanie E Combs, Wolfgang Behnisch, Andreas E Kulozik, Peter E Huber, Jürgen Debus and Daniela Schulz-Ertner

    Citation: BMC Cancer 2007 7:177

    Content type: Research article

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  6. Interleukin-8 (IL-8) is a cytokine that plays an important role in tumor progression in a variety of cancer types; however, its regulation is not well understood in oral cancer cells. In the present study, we ...

    Authors: Hwa-Jeong Lee, Jun Lee, Sun-Kyung Lee, Suk-Keun Lee and Eun-Cheol Kim

    Citation: BMC Cancer 2007 7:176

    Content type: Research article

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  7. Previously, 50% of patients with breast ductal carcinoma in situ (DCIS) had more than one nuclear grade, and neither worst nor predominant nuclear grade was significantly associated with development of invasive c...

    Authors: Judith-Anne W Chapman, Naomi A Miller, H Lavina A Lickley, Jin Qian, William A Christens-Barry, Yuejiao Fu, Yan Yuan and David E Axelrod

    Citation: BMC Cancer 2007 7:174

    Content type: Research article

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  8. The host immunogenetic background plays an important role in the development of breast cancer. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) is a molecule expressed predominantly on activated T cells and is import...

    Authors: Lihong Wang, Dalin Li, Zhenkun Fu, Heng Li, Wei Jiang and Dianjun Li

    Citation: BMC Cancer 2007 7:173

    Content type: Research article

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  9. The prognosis of patients with hepatocellular carcinoma (HCC) still remains very dismal, which is mainly due to metastasis. In our previous studies, we found that chromosome 8p deletions might contribute to me...

    Authors: Ke-Feng Lei, Yan-Fang Wang, Xiao-Qun Zhu, Peng-Cheng Lu, Bing-Sheng Sun, Hu-Liang Jia, Ning Ren, Qing-Hai Ye, Hui-Chuan Sun, Lu Wang, Zhao-You Tang and Lun-Xiu Qin

    Citation: BMC Cancer 2007 7:172

    Content type: Research article

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  10. Contrast enhanced ultrasound (CEUS) is an imaging technique which appeared on the market around the year 2000 and proposed for the detection of liver metastases in gastrointestinal cancer patients, a setting i...

    Authors: Fabio Piscaglia, Francesco Corradi, Mikaela Mancini, Francesco Giangregorio, Stefano Tamberi, Giampaolo Ugolini, Bruno Cola, Alberto Bazzocchi, Roberto Righini, Patrizia Pini, Fabio Fornari and Luigi Bolondi

    Citation: BMC Cancer 2007 7:171

    Content type: Research article

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  11. Male breast cancer (MBC) is a rare disease and little is known about its aetiology. Germ-line mutations of BRCA2 and, at lower frequency, of BRCA1 are implicated in a relatively small proportion of MBC cases. Com...

    Authors: Domenico Palli, Mario Falchetti, Giovanna Masala, Ramona Lupi, Francesco Sera, Calogero Saieva, Cristina D'Amico, Marco Ceroti, Piera Rizzolo, Maria Adelaide Caligo, Ines Zanna and Laura Ottini

    Citation: BMC Cancer 2007 7:170

    Content type: Research article

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  12. The functional and clinical significance of 14-3-3 proteins in human cancers remain largely undetermined. Earlier, we have reported differential expression of 14-3-3ζ mRNA in oral squamous cell carcinoma (OSCC...

    Authors: Ajay Matta, Sudhir Bahadur, Ritu Duggal, Siddhartha D Gupta and Ranju Ralhan

    Citation: BMC Cancer 2007 7:169

    Content type: Research article

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  13. p53 is commonly inactivated by mutations in the DNA-binding domain in a wide range of cancers. As mutant p53 often influences response to therapy, effective and rapid methods to scan for mutations in TP53 are lik...

    Authors: Michael Krypuy, Ahmed Ashour Ahmed, Dariush Etemadmoghadam, Sarah J Hyland, Anna deFazio, Stephen B Fox, James D Brenton, David D Bowtell and Alexander Dobrovic

    Citation: BMC Cancer 2007 7:168

    Content type: Research article

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  14. Many patients suffer from severe shoulder complaints after breast cancer surgery and axillary lymph node dissection. Physiotherapy has been clinically observed to improve treatment of these patients. However, ...

    Authors: Carien HG Beurskens, Caro JT van Uden, Luc JA Strobbe, Rob AB Oostendorp and Theo Wobbes

    Citation: BMC Cancer 2007 7:166

    Content type: Research article

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  15. Inflammatory cells in the tumour stroma has gained increasing interest recently. Thus, we aimed to study the frequency and prognostic impact of stromal mast cells and tumour infiltrating eosinophils in invasiv...

    Authors: Rose-Marie Amini, Kirsimari Aaltonen, Heli Nevanlinna, Ricardo Carvalho, Laura Salonen, Päivi Heikkilä and Carl Blomqvist

    Citation: BMC Cancer 2007 7:165

    Content type: Research article

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  16. Polymorphisms in DNA repair genes have been associated to repair DNA lesions, and might contribute to the individual susceptibility to develop different types of cancer. Nucleotide excision repair (NER), base ...

    Authors: M Felicitas López-Cima, Patricia González-Arriaga, Laura García-Castro, Teresa Pascual, Manuel G Marrón, Xose S Puente and Adonina Tardón

    Citation: BMC Cancer 2007 7:162

    Content type: Research article

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  17. Induction of apoptosis is one strategy for treatment of prostate cancer. The Shb adapter protein has been found to regulate apoptosis in various cell types and consequently human prostate cancer 3 (PC3) cells ...

    Authors: Padideh Davoodpour, Maréne Landström and Michael Welsh

    Citation: BMC Cancer 2007 7:161

    Content type: Research article

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  18. Young women presenting with breast cancer are more likely to have a genetic predisposition to the disease than breast cancer patients in general. A genetic predisposition is known to increase the risk of new p...

    Authors: Diana Eccles, Sue Gerty, Peter Simmonds, Victoria Hammond, Sarah Ennis and Douglas G Altman

    Citation: BMC Cancer 2007 7:160

    Content type: Study protocol

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  19. Interferon-α (IFN-α) is one of the central agents in immunotherapy for renal cell carcinoma (RCC) and binds to the IFN-α receptor (IFNAR). We investigated the role of IFNAR in RCC.

    Authors: Takao Kamai, Yoshiaki Yanai, Kyoko Arai, Hideyuki Abe, Tomonori Yamanishi, Masashi Kurimoto and Ken-Ichiro Yoshida

    Citation: BMC Cancer 2007 7:159

    Content type: Research article

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  20. Interferons are a group of proteins that trigger multiple responses including prevention of viral replication, inhibition of cell growth, and modulation of cell differentiation. In different mammary carcinoma ...

    Authors: Ignacio García-Tuñón, Mónica Ricote, Antonio Ruiz A, Benito Fraile, Ricardo Paniagua and Mar Royuela

    Citation: BMC Cancer 2007 7:158

    Content type: Research article

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  21. Adenoid Cystic Carcinoma (ACC) is a rare tumor entity and comprises about 1% of all malignant tumor of the oral and maxillofacial region. It is slow growing but a highly invasive cancer with a high recurrence ...

    Authors: Amal Abdul-Hussein, Pierre A Morris and Tsveti Markova

    Citation: BMC Cancer 2007 7:157

    Content type: Case report

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  22. Histological phenotype and clinical behaviour of malignant tumours are not only dependent on alterations in the epithelial cell compartment, but are affected by their interaction with inflammatory cells and tu...

    Authors: David Bacman, Susanne Merkel, Roland Croner, Thomas Papadopoulos, Wolfgang Brueckl and Arno Dimmler

    Citation: BMC Cancer 2007 7:156

    Content type: Research article

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  23. Combination of platinum derivatives with paclitaxel is currently the standard front line regimen for patients with epithelial ovarian carcinoma, and represents also an active regimen in patients with metastati...

    Authors: Bohuslav Melichar, Radomír Hyšpler, Emanuela Dragounová, Josef Dvořák, Hana Kalábová and Alena Tichá

    Citation: BMC Cancer 2007 7:155

    Content type: Research article

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  24. Colorectal cancer (CRC) diagnosis and the ensuing treatments can have a substantial impact on the physical and psychological health of survivors. As the number of CRC survivors increases, so too does the need ...

    Authors: Rosalind R Spence, Kristiann C Heesch, Elizabeth G Eakin and Wendy J Brown

    Citation: BMC Cancer 2007 7:154

    Content type: Study protocol

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  25. Breast cancer is the most common cancer in women in the U.S. and Western Europe. Amplification of the her-2/neu gene occurs in approximately 25% of invasive ductal carcinomas of the breast. The first HER-2/neu...

    Authors: Gustavo A Viani, Sergio L Afonso, Eduardo J Stefano, Ligia I De Fendi and Francisco V Soares

    Citation: BMC Cancer 2007 7:153

    Content type: Research article

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  26. Erlotinib is a Human Epidermal Growth Factor Receptor Type 1/tyrosine kinase (EGFR) inhibitor which is used for non-small-cell lung cancer treatment. Despite that erlotinib is considered to have a favorable sa...

    Authors: Demosthenes Makris, Arnaud Scherpereel, Marie Christine Copin, Guillaume Colin, Luc Brun, Jean Jacques Lafitte and Charles Hugo Marquette

    Citation: BMC Cancer 2007 7:150

    Content type: Case report

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  27. C4-2 prostate cancer (CaP) cells grown in mouse tibiae cause a mixed osteoblastic/osteolytic response with increases in osteoclast numbers and bone resorption. Administration of osteoprotegerin (OPG) blocks th...

    Authors: Colm Morrissey, Paul L Kostenuik, Lisha G Brown, Robert L Vessella and Eva Corey

    Citation: BMC Cancer 2007 7:148

    Content type: Research article

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  28. The use of combined positron emission tomography/computerised tomography (PET/CT) scanners in oncology has been shown to improve the staging of tumours and the detection of relapses. However, mis-registration ...

    Authors: Jayson Wang, Gary Cook, John Frank, Roberto Dina, Naomi Livni, John Lynn, William Fleming and Michael J Seckl

    Citation: BMC Cancer 2007 7:147

    Content type: Case report

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  29. c-Jun/AP-1 has been linked to invasive properties of aggressive breast cancer. Recently, it has been reported that overexpression of c-Jun in breast cancer cell line MCF-7 resulted in increased AP-1 activity, ...

    Authors: Yan Zhang, Xiaoyun Pu, Ming Shi, Liyong Chen, Yuhua Song, Lu Qian, Guogang Yuan, Hao Zhang, Ming Yu, Meiru Hu, Beifen Shen and Ning Guo

    Citation: BMC Cancer 2007 7:145

    Content type: Research article

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  30. Synoptic reporting, either as part of the pathology report or replacing some free text component incorporates standardized data elements in the form of checklists for pathology reporting. This ensures the path...

    Authors: Sambit K Mohanty, Anthony L Piccoli, Lisa J Devine, Ashokkumar A Patel, Gross C William, Sharon B Winters, Michael J Becich and Anil V Parwani

    Citation: BMC Cancer 2007 7:144

    Content type: Research article

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  31. Squamous cell carcinoma of the head and neck (SCCHN) often contain highly radioresistant hypoxic regions, nonetheless, radiotherapy is a common treatment modality for these tumours. Reoxygenation during fracti...

    Authors: Daniela Schilling, Christine Bayer, Anneke Geurts-Moespot, Fred CGJ Sweep, Martin Pruschy, Karin Mengele, Lisa D Sprague and Michael Molls

    Citation: BMC Cancer 2007 7:143

    Content type: Research article

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  32. Docetaxel is the standard first-line agent for the treatment of androgen-independent prostate cancer (AIPC). The combination of docetaxel with molecularly targeted therapies may offer the potential to increase...

    Authors: Mitchell Gross, Celestia Higano, Allan Pantuck, Olga Castellanos, Erica Green, Koo Nguyen and David B Agus

    Citation: BMC Cancer 2007 7:142

    Content type: Research article

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  33. Metastases to the central nervous system from different primary cancers are an oncologic challenge as the overall prognosis for these patients is generally poor. The incidence of brain metastases varies with t...

    Authors: Torill E Sjøbakk, Roar Johansen, Tone F Bathen, Ursula Sonnewald, Kjell A Kvistad, Steinar Lundgren and Ingrid S Gribbestad

    Citation: BMC Cancer 2007 7:141

    Content type: Research article

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  34. Aminopeptidase N (APN/CD13), a 150-kDa metalloprotease, is a multifunctional cell surface aminopeptidase with ubiquitous expression. Recent studies have suggested that APN/CD13 plays an important role in tumor...

    Authors: Mikio Terauchi, Hiroaki Kajiyama, Kiyosumi Shibata, Kazuhiko Ino, Akihiro Nawa, Shigehiko Mizutani and Fumitaka Kikkawa

    Citation: BMC Cancer 2007 7:140

    Content type: Research article

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  35. Arachidonate metabolites are important regulators of human breast cancer cells. Production of bioactive lipids are frequently initiated by the enzyme phospholipase A2 which releases arachidonic acid (AA) that ...

    Authors: Rasha Hammamieh, Dena Sumaida, XiaoYan Zhang, Rina Das and Marti Jett

    Citation: BMC Cancer 2007 7:138

    Content type: Research article

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  36. The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinoma...

    Authors: Katherine AB Knostman, James A McCubrey, Carl D Morrison, Zhaoxia Zhang, Charles C Capen and Sissy M Jhiang

    Citation: BMC Cancer 2007 7:137

    Content type: Research article

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  37. Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat pathway. Recent in vivo and in vitro studies suggest th...

    Authors: Michael C Haffner, Barbara Petridou, Jean Phillipe Peyrat, Françoise Révillion, Elisabeth Müller-Holzner, Günter Daxenbichler, Christian Marth and Wolfgang Doppler

    Citation: BMC Cancer 2007 7:136

    Content type: Research article

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  38. Inflammatory cytokines may promote tumorigenesis. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with regulatory properties over tumor suppressor proteins involved in bladder cancer...

    Authors: John A Taylor III, George A Kuchel, Poornima Hegde, Olga S Voznesensky, Kevin Claffey, John Tsimikas, Lin Leng, Richard Bucala and Carol Pilbeam

    Citation: BMC Cancer 2007 7:135

    Content type: Research article

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  39. Basal-like breast cancer has been extensively characterized on the basis of gene expression profiles, but it is becoming increasingly common for these tumors to be defined on the basis of immunohistochemical (...

    Authors: Marc Tischkowitz, Jean-Sébastien Brunet, Louis R Bégin, David G Huntsman, Maggie CU Cheang, Lars A Akslen, Torsten O Nielsen and William D Foulkes

    Citation: BMC Cancer 2007 7:134

    Content type: Research article

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  40. Aberrant promoter hypermethylation of cancer-associated genes occurs frequently during carcinogenesis and may serve as a cancer biomarker. In this study we aimed at defining a quantitative gene promoter methyl...

    Authors: Vera L Costa, Rui Henrique, Franclim R Ribeiro, Mafalda Pinto, Jorge Oliveira, Francisco Lobo, Manuel R Teixeira and Carmen Jerónimo

    Citation: BMC Cancer 2007 7:133

    Content type: Research article

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