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  1. Anthracycline-based adjuvant chemotherapy improves survival in patients with high-risk node-negative breast cancer (BC). In this setting, prognostic factors predicting for treatment failure might help selectin...

    Authors: S. Rahal, J M Boher, J M Extra, C. Tarpin, E. Charafe-Jauffret, E. Lambaudie, R. Sabatier, J. Thomassin-Piana, A. Tallet, M. Resbeut, G. Houvenaeghel, L. Laborde, F. Bertucci, P. Viens and A. Gonçalves
    Citation: BMC Cancer 2015 15:697
    Content type: Research article Published on:

  2. The incidence of multiple primary malignancies (MPM) has increased sharply in recent decades. However, the clinical characteristics and prognosis of MPM patients involving lung cancer were not fully elucidated...

    Authors: Feng Li, Wen-Zhao Zhong, Fei-Yu Niu, Ning Zhao, Jin-Ji Yang, Hong-Hong Yan and Yi-Long Wu
    Citation: BMC Cancer 2015 15:696
    Content type: Research article Published on:

  3. The clinical benefit of cetuximab combined with oxaliplatin-based chemotherapy remains under debate. The aim of the present multicenter open-label Phase II study was to explore the efficacy and safety of biwee...

    Authors: Hitoshi Soda, Hiromichi Maeda, Junichi Hasegawa, Takao Takahashi, Shoichi Hazama, Mutsumi Fukunaga, Emiko Kono, Masahito Kotaka, Junichi Sakamoto, Naoki Nagata, Koji Oba and Hideyuki Mishima
    Citation: BMC Cancer 2015 15:695
    Content type: Research article Published on:

  4. Collagen XI is a key structural component of the extracellular matrix and consists of three alpha chains. One of these chains, the α1 (XI), is encoded by the COL11A1 gene and is transcribed to four different vari...

    Authors: Makrina Karaglani, Ioannis Toumpoulis, Nikolaos Goutas, Nikoleta Poumpouridou, Dimitrios Vlachodimitropoulos, Spyridon Vasilaros, Ioannis Rizos and Christos Kroupis
    Citation: BMC Cancer 2015 15:694
    Content type: Research article Published on:

  5. The aim of this study was to assess the efficacy and safety of a combination regimen of capecitabine plus cisplatin (CC) or capecitabine plus paclitaxel (CP) as a first-line treatment in patients with metastat...

    Authors: Su Jin Lee, Sungmin Kim, Moonjin Kim, Jeeyun Lee, Yeon Hee Park, Young-Hyuck Im and Se Hoon Park
    Citation: BMC Cancer 2015 15:693
    Content type: Research article Published on:

  6. Breast cancer (BC) cells secrete soluble factors that accelerate osteoclast (OC) differentiation, leading to the formation of osteolytic bone metastases. In the BOLERO-2 trial, BC patients with bone involvemen...

    Authors: Valeria Simone, Sabino Ciavarella, Oronzo Brunetti, Annalisa Savonarola, Mauro Cives, Marco Tucci, Giuseppina Opinto, Eugenio Maiorano and Franco Silvestris
    Citation: BMC Cancer 2015 15:692
    Content type: Research article Published on:

  7. Statistics regarding HPV prevalence and cervical cancer rates in rural China are high, however, low levels of HPV awareness and HPV-related knowledge pose a great challenge for cervical cancer control.

    Authors: Jing Li, Le-Ni Kang, Bayi Li, Yi Pang, Rong Huang and You-Lin Qiao
    Citation: BMC Cancer 2015 15:691
    Content type: Research article Published on:

  8. Asian population has different body mass index (BMI) profile compared to Caucasian population. However, the effect of obesity and body weight gain in Asian colorectal cancer patients treated with adjuvant chem...

    Authors: Dae-Won Lee, Sae-Won Han, Yongjun Cha, Kyung-Hun Lee, Tae-Yong Kim, Do-Youn Oh, Seock-Ah Im, Yung-Jue Bang, Ji Won Park, Seung-Bum Ryoo, Seung-Yong Jeong, Gyeong Hoon Kang, Kyu Joo Park and Tae-You Kim
    Citation: BMC Cancer 2015 15:690
    Content type: Research article Published on:

  9. Integrated health care delivery systems, with their comprehensive and integrated electronic medical records (EMR), are well-poised to conduct research that leverages the detailed clinical data within the EMRs....

    Authors: Scarlett Lin Gomez, Salma Shariff-Marco, Julie Von Behren, Marilyn L. Kwan, Candyce H. Kroenke, Theresa H. M. Keegan, Peggy Reynolds and Lawrence H. Kushi
    Citation: BMC Cancer 2015 15:688
    Content type: Research article Published on:

  10. PH domain Leucine-rich-repeats protein phosphatase (PHLPP) is a novel family of Ser/Thr protein dephosphatases that play a critical role in maintaining the balance in cell signaling. PHLPP negatively regulates...

    Authors: Dongqing Lv, Haihua Yang, Wei Wang, Youyou Xie, Wei Hu, Minhua Ye and Xiaofeng Chen
    Citation: BMC Cancer 2015 15:687
    Content type: Research article Published on:

  11. MDT (multidisciplinary team) meetings are considered an essential component of care for patients with cancer. However there is remarkably little direct evidence that such meetings improve outcomes. We assessed...

    Authors: Alastair Munro, Mhari Brown, Paddy Niblock, Robert Steele and Frank Carey
    Citation: BMC Cancer 2015 15:686
    Content type: Research article Published on:

  12. Brain metastases are an increasing problem in women with invasive breast cancer. Strategies designed to treat brain metastases of breast cancer, particularly chemotherapeutics such as irinotecan, demonstrate l...

    Authors: Chris E. Adkins, Mohamed I. Nounou, Tanvirul Hye, Afroz S. Mohammad, Tori Terrell-Hall, Neel K. Mohan, Michael A. Eldon, Ute Hoch and Paul R. Lockman
    Citation: BMC Cancer 2015 15:685
    Content type: Research article Published on:

  13. The aim of this study was to explore the efficacy and define mechanisms of action of PRIMA-1MET as a TP53 targeted therapy in soft-tissue sarcoma (STS) cells.

    Authors: Thomas Grellety, Audrey Laroche-Clary, Vanessa Chaire, Pauline Lagarde, Frédéric Chibon, Agnes Neuville and Antoine Italiano
    Citation: BMC Cancer 2015 15:684
    Content type: Research article Published on:

  14. ATP-binding cassette (ABC) transporters are transmembrane proteins responsible for the efflux of a wide variety of substrates, including steroid metabolites, through the cellular membranes. For better characte...

    Authors: Rita Demidenko, Deividas Razanauskas, Kristina Daniunaite, Juozas Rimantas Lazutka, Feliksas Jankevicius and Sonata Jarmalaite
    Citation: BMC Cancer 2015 15:683
    Content type: Research article Published on:

  15. Hesperidin (30, 5, 9-dihydroxy-40-methoxy-7-orutinosyl flavanone) is a flavanone that is found mainly in citrus fruits and has been shown to have some anti-neoplastic effects. The aim of the present study was ...

    Authors: Yaoxian Wang, Hui Yu, Jin Zhang, Jing Gao, Xin Ge and Ge Lou
    Citation: BMC Cancer 2015 15:682
    Content type: Research article Published on:

  16. Cancer-testis antigens are among the new promising biomarkers, especially for targeted therapy. Aberrant and specific expression of these proteins has been reported in some tumor tissues. Also understanding th...

    Authors: Rezvan Esmaeili, Keivan Majidzadeh-A, Leila Farahmand, Maryam Ghasemi, Malihe Salehi and Ali Reza Khoshdel
    Citation: BMC Cancer 2015 15:681
    Content type: Research article Published on:

  17. Cervical cancer is one of the most important cancers worldwide with a high incident and mortality rate and is caused by the human papilloma virus (HPV). Among sexually active women who get infected with human ...

    Authors: Koushik Chattopadhyay, Anna-Lise Williamson, Annapurna Hazra and Collet Dandara
    Citation: BMC Cancer 2015 15:680
    Content type: Research article Published on:

  19. Organ site-specific metastasis is an ominous feature for most poor-prognostic hepatocellular carcinoma (HCC) patients. Cancer cell lines and animal models are indispensable for investigating the molecular mech...

    Authors: Jinliang Wan, Duo Wen, Lili Dong, Jun Tang, Dongli Liu, Yang Liu, Zhonghua Tao, Dongmei Gao, Huichuan Sun, Ya Cao, Jia Fan and Weizhong Wu
    Citation: BMC Cancer 2015 15:678
    Content type: Research article Published on:

  20. In the era of personalized medicine, head and neck squamous cell carcinoma (HNSCC) represents a critical oncologic topic. Conventional chemotherapy regimens consist of drugs administration in cycles near or at...

    Authors: Francesca De Felice, Daniela Musio and Vincenzo Tombolini
    Citation: BMC Cancer 2015 15:677
    Content type: Review Published on:

  21. Increased mesenchymal–epithelial transition factor gene (c-MET) expression in several human malignancies is related to increased tumour progression. The aim of the present study is to explore the relationship ...

    Authors: Jaudah Al-Maghrabi, Eman Emam, Wafaey Gomaa, Moaath Saggaf, Abdelbaset Buhmeida, Mohammad Al-Qahtani and Mahmoud Al-Ahwal
    Citation: BMC Cancer 2015 15:676
    Content type: Research article Published on:

  22. SUMOylation, an important post-translational modification, associates with the development of hepatocellular carcinoma (HCC). p65, one of the most important subunits of NF-κB, is a key regulator in the develop...

    Authors: Jun Liu, Manqi Sha, Qianfeng Wang, Yong Ma, Xiaoping Geng, Yufeng Gao, Lijie Feng, Yujun Shen and Yuxian Shen
    Citation: BMC Cancer 2015 15:675
    Content type: Research article Published on:

  23. Proven cost-effectiveness contrasted by low uptake of cancer screening (CS) calls for new methodologies promoting the service. Contemporary interventions in this regard relies primarily on strategies targeting...

    Authors: Rui Feng, Xingrong Shen, Jing Chai, Penglai Chen, Jing Cheng, Han Liang, Ting Zhao, Rui Sha, Kaichun Li and Debin Wang
    Citation: BMC Cancer 2015 15:674
    Content type: Study protocol Published on:

  24. It is known that cetuximab (an epidermal growth factor receptor [EGFr] inhibitor) is a radiosensitizer. Also, cetuximab is known to only partially inhibit the signal transducer and activator of transcription –...

    Authors: James A. Bonner, Hoa Q. Trummell, Andrew B. Bonner, Christopher D. Willey, Markus Bredel and Eddy S. Yang
    Citation: BMC Cancer 2015 15:673
    Content type: Research article Published on:

  25. Nutrition is believed to be a primary contributor in regulating gene expression by affecting epigenetic pathways such as DNA methylation and histone modification. Resveratrol and pterostilbene are phytoalexins...

    Authors: Rishabh Kala, Harsh N. Shah, Samantha L. Martin and Trygve O. Tollefsbol
    Citation: BMC Cancer 2015 15:672
    Content type: Research article Published on:

  26. Since the breast cancer screening programme in the Basque Country (BCSPBC) was started in 1996, more than 400,000 women aged 50 to 69 years have been invited to participate. Based on epidemiological observatio...

    Authors: Arantzazu Arrospide, Montserrat Rue, Nicolien T. van Ravesteyn, Merce Comas, Nerea Larrañaga, Garbiñe Sarriugarte and Javier Mar
    Citation: BMC Cancer 2015 15:671
    Content type: Research article Published on:

  27. There remains uncertainty in whether vitamin D status affects cancer survival. We investigated whether vitamin D (± calcium) supplementation affects cancer survival in women.

    Authors: Mona Jeffreys, Maria Theresa Redaniel and Richard M. Martin
    Citation: BMC Cancer 2015 15:670
    Content type: Research article Published on:

  28. Patients with breast cancer have an increased risk of developing subsequent breast cancers. It is important to distinguish whether these tumours are de novo or recurrences of the primary tumour in order to guide ...

    Authors: Katie T. Huang, Thomas Mikeska, Jason Li, Elena A. Takano, Ewan K A Millar, Peter H. Graham, Samantha E. Boyle, Ian G. Campbell, Terence P. Speed, Alexander Dobrovic and Stephen B. Fox
    Citation: BMC Cancer 2015 15:669
    Content type: Research article Published on:

  29. The oncogenic transcription factor MYC is pathologically activated in many human malignancies. A paradigm for MYC dysregulation is offered by Burkitt lymphoma, where chromosomal translocations leading to Immunogl...

    Authors: Giulia De Falco, Maria Raffaella Ambrosio, Fabio Fuligni, Anna Onnis, Cristiana Bellan, Bruno Jim Rocca, Mohsen Navari, Maryam Etebari, Lucia Mundo, Sara Gazaneo, Fabio Facchetti, Stefano A. Pileri, Lorenzo Leoncini and Pier Paolo Piccaluga
    Citation: BMC Cancer 2015 15:668
    Content type: Research article Published on:

  30. To improve antitumor effects against metastatic renal cell carcinoma (mRCC), use of molecular target-based drugs in sequential or combination therapy has been advocated. In combination therapy, interferon (IFN...

    Authors: Masatoshi Eto, Yoshiaki Kawano, Yoshihiko Hirao, Koji Mita, Yoichi Arai, Taiji Tsukamoto, Katsuyoshi Hashine, Akio Matsubara, Tomoaki Fujioka, Go Kimura, Nobuo Shinohara, Katsunori Tatsugami, Shiro Hinotsu and Seiji Naito
    Citation: BMC Cancer 2015 15:667
    Content type: Research article Published on:

  31. In the past decades, mortality of female gender related cancers declined in Switzerland and other developed countries. Differences in the decrease and in spatial patterns within Switzerland have been reported ...

    Authors: Christian Herrmann, Silvia Ess, Beat Thürlimann, Nicole Probst-Hensch and Penelope Vounatsou
    Citation: BMC Cancer 2015 15:666
    Content type: Research article Published on:

  32. After surgical resection of hepatocellular carcinoma (HCC), recurrence is common, especially in patients presenting with vascular invasion or multifocal disease after curative surgery. Consequently, we examine...

    Authors: Chung-Lin Hung, Chia-Shen Yen, Hung-Wen Tsai, Yu-Chieh Su and Chia-Jui Yen
    Citation: BMC Cancer 2015 15:665
    Content type: Research article Published on:

  33. Dogs spontaneously develop invasive mammary carcinoma with a high prevalence of the triple-negative (TN) subtype (lack of ER-Estrogen Receptor and PR-Progesterone Receptor expression, lack of HER2-Human Epider...

    Authors: Laetitia Jaillardon, Jérome Abadie, Tiffanie Godard, Mario Campone, Delphine Loussouarn, Brigitte Siliart and Frédérique Nguyen
    Citation: BMC Cancer 2015 15:664
    Content type: Research article Published on:

  34. T-cell acute lymphoblastic leukemia (T-ALL) is a genetically heterogeneous disease with the need for treatment optimization. Previously, high expression of Insulin-like growth factor binding protein 7 (IGFBP7)...

    Authors: Isabelle Bartram, Ulrike Erben, Jutta Ortiz-Tanchez, Katja Blunert, Cornelia Schlee, Martin Neumann, Sandra Heesch and Claudia D. Baldus
    Citation: BMC Cancer 2015 15:663
    Content type: Research article Published on:

  35. Magnetic resonance imaging (MRI) may guide breast cancer surgery by measuring residual tumor size post-neoadjuvant chemotherapy (NAC). Accurate measurement may avoid overly radical surgery or reduce the need f...

    Authors: Michael L. Marinovich, Petra Macaskill, Les Irwig, Francesco Sardanelli, Eleftherios Mamounas, Gunter von Minckwitz, Valentina Guarneri, Savannah C. Partridge, Frances C. Wright, Jae Hyuck Choi, Madhumita Bhattacharyya, Laura Martincich, Eren Yeh, Viviana Londero and Nehmat Houssami
    Citation: BMC Cancer 2015 15:662
    Content type: Research article Published on:

  36. Different strategies have been proposed to target neoangiogenesis in gliomas, besides those targeting Vascular Endothelial Growth Factor (VEGF). The chemokine Interleukin-8 (IL-8) has been shown to possess bot...

    Authors: Enrica Fabbri, Eleonora Brognara, Giulia Montagner, Claudio Ghimenton, Albino Eccher, Cinzia Cantù, Susanna Khalil, Valentino Bezzerri, Lisa Provezza, Nicoletta Bianchi, Alessia Finotti, Monica Borgatti, Giuseppe Moretto, Marco Chilosi, Giulio Cabrini and Roberto Gambari
    Citation: BMC Cancer 2015 15:661
    Content type: Research article Published on:

  37. The REversion-inducing Cysteine-rich protein with Kazal motif (RECK) is a well-known inhibitor of matrix metalloproteinases (MMPs) and cellular invasion. Although high expression levels of RECK have already be...

    Authors: Luciana R. Gomes, André Fujita, Joni D. Mott, Fernando A. Soares, Leticia Labriola and Mari C. Sogayar
    Citation: BMC Cancer 2015 15:660
    Content type: Research article Published on:

  38. Our retrospective, international study aimed at evaluating the activity and safety of eribulin mesylate (EM) in pretreated metastatic breast cancer (MBC) in a routine clinical setting.

    Authors: Mélodie Dell’Ova, Eléonora De Maio, Séverine Guiu, Lise Roca, Florence Dalenc, Anna Durigova, Frédéric Pinguet, Khedidja Bekhtari, William Jacot and Stéphane Pouderoux
    Citation: BMC Cancer 2015 15:659
    Content type: Research article Published on:

  40. Since targeting oxidative stress markers has been recently recognized as a novel therapeutic target in cancer, it is interesting to investigate whether genetic susceptibility may modify oxidative stress respon...

    Authors: Ewa Jablonska, Jolanta Gromadzinska, Beata Peplonska, Wojciech Fendler, Edyta Reszka, Magdalena B. Krol, Edyta Wieczorek, Agnieszka Bukowska, Peter Gresner, Michal Galicki, Oskar Zambrano Quispe, Zbigniew Morawiec and Wojciech Wasowicz
    Citation: BMC Cancer 2015 15:657
    Content type: Research article Published on:

  41. Locally recurrent non-small cell lung cancer (NSCLC) poses a great challenge to physicians. This study aimed to explore the efficacy and safety of the combination of brachytherapy and docetaxel and cisplatin f...

    Authors: Xiaojuan Yu, Jin Li, Xiaoming Zhong and Jingdong He
    Citation: BMC Cancer 2015 15:656
    Content type: Research article Published on:

  42. Anterior gradient 2 (AGR2) is a protein disulfide isomerase-like protein widely expressed in many normal tissues as well as cancers. In our study, non-neoplastic bronchial epithelial cells as well as non-small...

    Authors: Mohammed Alavi, Vei Mah, Erin L. Maresh, Lora Bagryanova, Steve Horvath, David Chia, Lee Goodglick and Alvin Y. Liu
    Citation: BMC Cancer 2015 15:655
    Content type: Research article Published on:

  43. Specific genes, such as BCAT1 and IKZF1, are methylated with high frequency in colorectal cancer (CRC) tissue compared to normal colon tissue specimens. Such DNA may leak into blood and be present as cell-free ci...

    Authors: Susanne K. Pedersen, Erin L. Symonds, Rohan T. Baker, David H. Murray, Aidan McEvoy, Sascha C. Van Doorn, Marco W. Mundt, Stephen R. Cole, Geetha Gopalsamy, Dileep Mangira, Lawrence C. LaPointe, Evelien Dekker and Graeme P. Young
    Citation: BMC Cancer 2015 15:654
    Content type: Research article Published on:

  44. Metastatic pancreatic adenocarcinoma (PAC) prognosis remains dismal and gemcitabine monotherapy has been the standard treatment over the last decade. Currently, two first-line regimens are used in this setting...

    Authors: Jean-Baptiste Bachet, Benoist Chibaudel, Franck Bonnetain, Pierre Validire, Pascal Hammel, Thierry André and Christophe Louvet
    Citation: BMC Cancer 2015 15:653
    Content type: Study protocol Published on:

  45. Preclinical evidence shows that short-term fasting (STF) protects healthy cells against side effects of chemotherapy and makes cancer cells more vulnerable to it. This pilot study examines the feasibility of S...

    Authors: Stefanie de Groot, Maaike PG Vreeswijk, Marij JP Welters, Gido Gravesteijn, Jan JWA Boei, Anouk Jochems, Daniel Houtsma, Hein Putter, Jacobus JM van der Hoeven, Johan WR Nortier, Hanno Pijl and Judith R Kroep
    Citation: BMC Cancer 2015 15:652
    Content type: Research article Published on:

  46. This analysis was undertaken to evaluate the practice patterns of Japanese physicians regarding curative-intent chemotherapy, especially in outpatient settings, and to define factors negatively affecting the m...

    Authors: Hitomi Sakai, Noriyuki Katsumata and Genmu Kadokura
    Citation: BMC Cancer 2015 15:651
    Content type: Research article Published on:

  47. It is difficult for the parotid gland neoplasms to make an accurate preoperative diagnosis due to the restriction of biopsy in the parotid gland neoplasms. The aim of this study is to apply the surface-enhance...

    Authors: Bing Yan, Bo Li, Zhining Wen, Xianyang Luo, Lili Xue and Longjiang Li
    Citation: BMC Cancer 2015 15:650
    Content type: Research article Published on:

  48. ATM and ATR are kinases implicated in a myriad of DNA-damage responses. ATM kinase inhibition radiosensitizes cells and selectively kills cells with Fanconi anemia (FA) gene mutations. ATR kinase inhibition se...

    Authors: Jan H. Beumer, Katherine Y. Fu, Bean N. Anyang, Jill M. Siegfried and Christopher J. Bakkenist
    Citation: BMC Cancer 2015 15:649
    Content type: Research article Published on:

  49. Inflammation can promote tumor growth, invasion, angiogenesis and even metastasis. Inflammatory markers have been identified as prognostic indicators in various malignances. This study compared the usefulness ...

    Authors: Yi Que, Haibo Qiu, Yuanfang Li, Yongming Chen, Wei Xiao, Zhiwei Zhou and Xing Zhang
    Citation: BMC Cancer 2015 15:648
    Content type: Research article Published on:

  50. Approximately 1 in 5 women diagnosed with breast cancer are considered to have in situ disease, most often termed ductal carcinoma in situ (DCIS). Though recognized as a risk factor for the development of more in...

    Authors: Whitney Barham, Lianyi Chen, Oleg Tikhomirov, Halina Onishko, Linda Gleaves, Thomas P. Stricker, Timothy S. Blackwell and Fiona E. Yull
    Citation: BMC Cancer 2015 15:647
    Content type: Research article Published on:

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