Ye F, Gao Q, Cai MJ. Therapeutic targeting of EGFR in malignant gliomas. Expert Opin Ther Targets. 2010;14:303–16.
Article
CAS
PubMed
Google Scholar
Bhattacharya D, Singh MK, Chaudhuri S, Acharya S, Basu AK, Chaudhuri S. T11TS impedes glioma angiogenesis by inhibiting VEGF signaling and pro-survival PI3K/Akt/eNOS pathway with concomitant upregulation of PTEN in brain endothelial cells. J Neurooncol. 2013;113:13–25.
Article
CAS
PubMed
Google Scholar
Narayan RS, Fedrigo CA, Stalpers LJ, Baumert BG, Sminia P. Targeting the Akt-pathway to improve radiosensitivity in glioblastoma. Curr Pharm Des. 2013;19:951–7.
Article
CAS
PubMed
Google Scholar
Nogueira L, Ruiz-Ontañon P, Vazquez-Barquero A, Moris F, Fernandez-Luna JL. The NFκB pathway: a therapeutic target in glioblastoma. Oncotarget. 2011;2:646–53.
Article
PubMed
PubMed Central
Google Scholar
Qiu B, Zhang D, Wang Y, Ou S, Wang J, Tao J, et al. Interleukin-6 is overexpressed and augments invasiveness of human glioma stem cells in vitro. Clin Exp Metastasis. 2013;30(8):1009–18. Epub Jul 6.
Lin Y, Zhang G, Zhang J, Gao G, Li M, Chen Y, et al. A panel of four cytokines predicts the prognosis of patients with malignant gliomas. J Neurooncol. 2013;114:199–208.
Yeung YT, McDonald KL, Grewal T, Munoz L. Interleukins in glioblastoma pathophysiology: implications for therapy. Br J Pharmacol. 2013;168:591–606.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhu VF, Yang J, Lebrun DG, Li M. Understanding the role of cytokines in Glioblastoma Multiforme pathogenesis. Cancer Lett. 2012;316:139–50.
Article
CAS
PubMed
Google Scholar
Dwyer J, Hebda JK, Le Guelte A, Galan-Moya EM, Smith SS, Azzi S, et al. Glioblastoma cell-secreted interleukin-8 induces brain endothelial cell permeability via CXCR2. PLoS One. 2012;7:e45562.
Fang KM, Wang YL, Huang MC, Sun SH, Cheng H, Tzeng SF. Expression of macrophage inflammatory protein-1α and monocyte chemoattractant protein-1 in glioma-infiltrating microglia: involvement of ATP and P2X receptor. J Neurosci Res. 2011;89:199–211.
Article
CAS
PubMed
Google Scholar
Bonavia R, Inda MM, Vandenberg S, Cheng SY, Nagane M, Hadwiger P, et al. EGFRvIII promotes glioma angiogenesis and growth through the NF-κB, interleukin-8 pathway. Oncogene. 2012;31:4054–66.
Raychaudhuri B, Vogelbaum MA. IL-8 is a mediator of NF-κB induced invasion by gliomas. J Neurooncol. 2011;101:227–35.
Article
CAS
PubMed
Google Scholar
Xie TX, Xia Z, Zhang N, Gong W, Huang S. Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma. Oncol Rep. 2010;23:725–32.
Article
CAS
PubMed
Google Scholar
Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 2005;7:122–33.
Article
CAS
PubMed
PubMed Central
Google Scholar
Neuschäfer-Rube F, Pathe-Neuschäfer-Rube A, Hippenstiel S, Kracht M, Püschel GP. NF-κB-dependent IL-8 induction by prostaglandin E(2) receptors EP(1) and EP(4). Br J Pharmacol. 2013;168:704–17.
Article
PubMed
PubMed Central
Google Scholar
Finotti A, Borgatti M, Bezzerri V, Nicolis E, Lampronti I, Dechecchi M, et al. Effects of decoy molecules targeting NF-kappaB transcription factors in Cystic fibrosis IB3-1 cells: recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene. Artif DNA PNA XNA. 2012;3:97–104.
Khanjani S, Terzidou V, Johnson MR, Bennett PR. NFκB and AP-1 drive human myometrial IL8 expression. Mediat Inflamm. 2012;504952:8.
Google Scholar
Bezzerri V, Borgatti M, Finotti A, Tamanini A, Gambari R, Cabrini G. Mapping the transcriptional machinery of the IL-8 gene in human bronchial epithelial cells. J Immunol. 2011;187:6069–81.
Article
CAS
PubMed
Google Scholar
Wei T, Xu N, Meisgen F, Ståhle M, Sonkoly E, Pivarcsi A. Interleukin-8 is regulated by miR-203 at the posttranscriptional level in primary human keratinocytes. Eur J Dermatol. 2013 Apr 19.
Perng DW, Yang DM, Hsiao YH, Lo T, Lee OK, Wu MT, et al. miRNA-146a expression positively regulates tumor necrosis factor-α-induced interleukin-8 production in mesenchymal stem cells and differentiated lung epithelial-like cells. Tissue Eng Part A. 2012;18:2259–67.
Chuang TD, Luo X, Panda H, Chegini N. miR-93/106b and their host gene, MCM7, are differentially expressed in leiomyomas and functionally target F3 and IL-8. Mol Endocrinol. 2012;26:1028–42.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhou R, Li X, Hu G, Gong AY, Drescher KM, Chen XM. miR-16 targets transcriptional corepressor SMRT and modulates NF-kappaB-regulated transactivation of interleukin-8 gene. PLoS One. 2012;7:e30772.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bhattacharyya S, Balakathiresan NS, Dalgard C, Gutti U, Armistead D, Jozwik C, et al. Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8. J Biol Chem. 2011;286:11604–15.
Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY). 2009;1:402–11.
Filipowicz W, Jaskiewicz L, Kolb FA, Pillai FS. Post-transcriptional gene silencing by siRNAs and miRNAs. Curr Opin Struct Biol. 2000;15:331–41.
Article
Google Scholar
Sontheimer EJ, Carthew RW. Silence from within: endogenous siRNAs and miRNAs. Cell. 2005;122:9–12.
Article
CAS
PubMed
Google Scholar
Alvarez-Garcia V, Miska EA. MicroRNA functions in animal development and human disease. Development. 2005;132:4653–62.
Article
CAS
PubMed
Google Scholar
Kailiang S, Lai EC. Adult-specific functions of animal microRNAs. Nat Rev Genet. 2013;14:535–48.
Google Scholar
Fabbri E, Borgatti M, Montagner G, Bianchi N, Finotti A, Lampronti I, et al. Expression of miR-93 and IL-8 during Pseudomonas aeruginosa mediated Induction of pro-Inflammatory responses. Am J Respir Cell Mol Biol. 2014;50:1144–55.
He J, Qian X, Carpenter R, Xu Q, Wang L, Qi Y, et al. Repression of miR-143 mediates Cr (VI)-induced tumor angiogenesis via IGF-IR/IRS1/ERK/IL-8 pathway. Toxicol Sci. 2013;134:26–38.
Hu N, Zhang J, Cui W, Kong G, Zhang S, Yue L, et al. miR-520b regulates migration of breast cancer cells by targeting hepatitis B X-interacting protein and interleukin-8. J Biol Chem. 2011;286:13714–22.
Keklikoglou I, Koerner C, Schmidt C, Zhang JD, Heckmann D, Shavinskaya A, et al. MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways. Oncogene. 2012;31:4150–63.
Yu Z, Willmarth NE, Zhou J, Katiyar S, Wang M, Liu Y, et al. MicroRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling. Proc Natl Acad Sci U S A. 2010;107:8231–6.
Fang L, Deng Z, Shatseva T, Yang J, Peng C, Du WW, et al. MicroRNA miR-93 promotes tumor growth and angiogenesis by targeting integrin-β8. Oncogene. 2011;30:806–21.
Long J, Wang Y, Wang W, Chang BH, Danesh FR. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions. J Biol Chem. 2010;285:23457–65.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tarassishin L, Lee SC. Interferon regulatory factor 3 alters glioma inflammatory and invasive properties. J Neurooncol. 2013;113:185–94.
Article
CAS
PubMed
Google Scholar
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007;114:97–109.
Cao X, Gu Y, Jiang L, Wang Y, Fang L, Yuqiao X, et al. A new approach to screening cancer stem cells from the U251 human glioma cell line based on cell growth state. Oncol Rep. 2013;29:1013–8.
Stein GH. T98G: an anchorage-independent human tumor cell line that exhibits stationary phase G1 arrest in vitro. J Cell Physiol. 1979;99:43–54.
Article
CAS
PubMed
Google Scholar
Borgatti M, Mancini I, Bianchi N, Guerrini A, Lampronti I, Rossi D, et al. Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines. BMC Biochem. 2011;15:12–5.
Penolazzi L, Lambertini E, Tavanti E, Torreggiani E, Vesce F, Gambari R, et al. Evaluation of chemokine and cytokine profiles in osteoblast progenitors from umbilical cord blood stem cells by Bio-Plex technology. Cell Biol Int. 2008;32:320–5.
Article
CAS
PubMed
Google Scholar
Fabbri E, Manicardi A, Tedeschi T, Sforza S, Bianchi N, Brognara E, et al. Modulation of the Biological Activity of microRNA-210 with Peptide Nucleic Acids (PNAs). ChemMedChem. 2011;12:2192–202.
Article
Google Scholar
Gambari R, Fabbri E, Borgatti M, Lampronti I, Finotti A, Brognara E, et al. Targeting microRNAs involved in human diseases: A novel approach for modification of gene expression and drug development. Biochem Pharmacol. 2011;82:1416–29.
Yu Y, Feng J, Zong X, Yang H, Zou D, He X. Knockdown of vascular endothelial cell growth factor expression sensitizes U251 glioma cells to liposomal paclitaxel and radiation treatment in vitro. Exp Ther Med. 2012;3:181–6.
CAS
PubMed
Google Scholar
Takahashi H, Inoue A, Kawabe Y, Hosokawa Y, Iwata S, Sugimoto K, et al. Oct-3/4 promotes tumor angiogenesis through VEGF production in glioblastoma. Brain Tumor Pathol. 2015;32:31–40.
Braganhol E, Kukulski F, Lévesque SA, Fausther M, Lavoie EG, Zanotto-Filho A, et al. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells. Biochim Biophys Acta. 2015;1852:120–30.
Nijaguna MB, Patil V, Hegde AS, Chandramouli BA, Arivazhagan A, Santosh V, et al. An Eighteen Serum Cytokine Signature for Discriminating Glioma from Normal Healthy Individuals. PLoS ONE. 2015;10(9).
Vartanian A, Singh SK, Agnihotri S, Jalali S, Burrell K, Aldape KD, et al. GBM’s multifaceted landscape: highlighting regional and microenvironmental heterogeneity. Neuro Oncol. 2014;16:1167–75.
Singh SK, Vartanian A, Burrell K, Zadeh G. A microRNA Link to Glioblastoma Heterogeneity. Cancers. 2012;4:846–72.
Article
CAS
PubMed
PubMed Central
Google Scholar
Petrocca F, Vecchione A, Croce CM. Emerging role of miR-106b-25/miR-17-92clusters in the control of transforming growth factor beta signaling. Cancer Res. 2008;68:8191–4.
Article
CAS
PubMed
Google Scholar
Codo P, Weller M, Meister G, Szabo E, Steinle A, Wolter M, Reifenberger G, Roth P. MicroRNA-mediated down-regulation of NKG2D ligands contributes to glioma immune escape. Oncotargets. 2014. Online ISSN: 1949–2553
Sun S, Wang Q, Giang A, Cheng C, Soo C, Wang CY, et al. Knockdown of CypA inhibits interleukin-8 (IL-8) and IL-8-mediated proliferation and tumor growth of glioblastoma cells through down-regulated NF-κB. J Neurooncol. 2011;101:1–14.
Gabellini C, Castellini L, Trisciuoglio D, Kracht M, Zupi G, Del Bufalo D. Involvement of nuclear factor-kappa B in bcl-xL-induced interleukin 8 expression in glioblastoma. J Neurochem. 2008;107:871–82.
Article
CAS
PubMed
Google Scholar
Yang TQ, Lu XJ, Wu TF, Ding DD, Zhao ZH, Chen GL, et al. MicroRNA-16 inhibits glioma cell growth and invasion through suppression of BCL2 and the nuclear factor-κB1/MMP9 signaling pathway. Cancer Sci. 2014;105:265–71.
Liu S, Patel SH, Ginestier C, Ibarra I, Martin-Trevino R, Bai S, et al. MicroRNA93 regulates proliferation and differentiation of normal and malignant breast stem cells. PLoS Genet. 2012;8:e1002751.
Yang G, Han D, Chen X, Zhang D, Wang L, Shi C, et al. MiR-196a exerts its oncogenic effect in glioblastoma multiforme by inhibition of IκBα both in vitro and in vivo. Neuro Oncol. 2014;16:652–61.
Magge SN, Malik SZ, Royo NC, Chen HI, Yu L, Snyder EY, et al. Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors. J Neurosci Res. 2009;87:1547–55.
Nazarenko I, Hede SM, He X, Hedrén A, Thompson J, Lindström MS, et al. PDGF and PDGF receptors in glioma. Ups J Med Sci. 2012;117:99–112.
Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013;19:1264–72.
van Engeland M, Nieland LJ, Ramaekers FC, Schutte B, Reutelingsperger CP. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry. 1998;31:1–9.
Article
PubMed
Google Scholar
McIlwain DR, Berger T, Mak TW. Caspase Functions in Cell Death and Disease. Cold Spring Harb Perspect Biol. 2013;5:a008656.
Article
PubMed
PubMed Central
Google Scholar
Brognara E, Fabbri E, Bazzoli E, Montagner G, Ghimenton C, Eccher A, et al. Uptake by human glioma cell lines and biological effects of a peptide-nucleic acids targeting miR-221. J Neurooncol. 2014;118:19–28.
Aboud OA, Wettersten HI, Weiss RH. Inhibition of PPARα Induces Cell Cycle Arrest and Apoptosis, and Synergizes with Glycolysis Inhibition in Kidney Cancer Cells. Plos One. 2013;8(8):e71115.
Article
PubMed
PubMed Central
Google Scholar