Escudier B, Eisen T, Stadler WM, Szczylik C, Oudard S, Siebels M, et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N Engl J Med. 2007;356:125–34.
Article
CAS
PubMed
Google Scholar
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, et al. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 2007;356:115–24.
Article
CAS
PubMed
Google Scholar
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med. 2007;356:2271–81.
Article
CAS
PubMed
Google Scholar
Iacovelli R, Alesini D, Palazzo A, Trenta P, Santoni M, De Marchis L, et al. A meta-analysis of published trials. Cancer Treat Rev. 2014;40:271–5.
Article
CAS
PubMed
Google Scholar
Powles T, Kayani I, Sharpe K, Lim L, Peters J, Stewart GD, et al. A prospective evaluation of VEGF-targeted treatment cessation in metastatic clear cell renal cancer. Ann Oncol. 2013;24:2098–103.
Article
CAS
PubMed
Google Scholar
Joosten SC, Hamming L, Soetekouw PM, Aarts MJ, Veeck J, van Engeland M, et al. Resistance to sunitinib in renal cell carcinoma: From molecular mechanisms to predictive markers and future perspectives. Biochim Biophys Acta. 1855;2015:1–16.
Google Scholar
Sosman JA, Puzanov I, Atkins MB. Opportunities and obstacles to combination targeted therapy in renal cell cancer. Clin Cancer Res. 2007;13(2 Pt 2):764s–9s.
Article
CAS
PubMed
Google Scholar
Négrier S, Gravis G, Pérol D, Chevreau C, Delva R, Bay JO, et al. Temsirolimus and bevacizumab, or sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): a randomised phase 2 trial. Lancet Oncol. 2011;12:673–80.
Article
PubMed
Google Scholar
Escudier B, Lassau N, Angevin E, Soria JC, Chami L, Lamuraglia M, et al. Phase I trial of sorafenib in combination with interferon alpha-2a in patients with unresectable and/or metastatic renal cell carcinoma and malignant. Clin Cancer Res. 2007;13:1801–9.
Article
CAS
PubMed
Google Scholar
Gollob JA, Rathmell WK, Richmond TM, Marino CB, Miller EK, Grigson G, et al. Phase II trial of sorafenib plus interferon alfa-2b as first- or second-line therapy in patients with metastatic renal cell cancer. J Clin Oncol. 2007;25:3288–95.
Article
CAS
PubMed
Google Scholar
Ryan CW, Goldman BH, Lara Jr PN, Mack PC, Beer TM, Tangen CM, et al. Sorafenib with interferon alfa-2b as first line treatment of advanced renal carcinoma: a phase II study of the Southwest Oncology Group. J Clin Oncol. 2007;25:3296–301.
Article
CAS
PubMed
Google Scholar
Takeuchi A, Eto M, Tatsugami K, Yamada H, Oki T, Kiyoshima K, et al. Mechanism of synergistic antitumor effect of sorafenib and interferon-α on treatment of renal cell carcinoma. J Urol. 2010;184:2549–56.
Article
CAS
PubMed
Google Scholar
Bracarda S, Porta C, Boni C, Santoro A, Mucciarini C, Pazzola A, et al. Could interferon still play a role in metastatic renal cell carcinoma? A randomized study of two schedules of sorafenib plus interferon-alpha 2a (RAPSODY). Eur Urol. 2013;63:254–61.
Article
CAS
PubMed
Google Scholar
Naito S, Yamamoto N, Takayama T, Muramoto M, Shinohara N, Nishiyama K, et al. Prognosis of Japanese metastatic renal cell carcinoma patients in the cytokine era: a cooperative group report of 1463 patients. Eur Urol. 2010;57:317–25.
Article
CAS
PubMed
Google Scholar
Eto M, Kamba T, Miyake H, Fujisawa M, Kamai T, Uemura H, et al. STAT3 Polymorphism Can Predict the Response to Interferon-α Therapy in Patients with Metastatic Renal Cell Carcinoma. Eur Urol. 2013;63:745–52.
Article
CAS
PubMed
Google Scholar
Therasse P, Eisenhauer EA, Verweij J. RECIST revisited: a review of validation studies on tumour assessment. Eur J Cancer. 2006;42:1031–9.
Article
CAS
PubMed
Google Scholar
Akaza H, Tsukamoto T, Murai M, Nakajima K, Naito S. Phase II study to investigate the efficacy, safety, and pharmacokinetics of sorafenib in Japanese patients with advanced renal cell carcinoma. Jpn J Clin Oncol. 2007;37:755–62.
Article
PubMed
Google Scholar
Kaplan EL, Meier P. Nonparametric estimation for incomplete observations. J Am Stat Assoc. 1958;52:457–81.
Article
Google Scholar
Folkman J, Browder T, Palmblad J. Angiogenesis research: guidelines for translation to clinical application. Thromb Haemost. 2001;86:22–33.
Google Scholar
Melichar B, Koralewski P, Ravaud A, Pluzanska A, Bracarda S, Szczylik C, et al. First-line bevacizumab combined with reduced dose interferon-alpha2a is active in patients with metastatic renal cell carcinoma. Ann Oncol. 2008;19:1470–6.
Article
CAS
PubMed
Google Scholar
Jonasch E, Corn P, Pagliaro LC, Warneke CL, Johnson MM, Tamboli P, et al. Upfront, randomized, phase 2 trial of sorafenib versus sorafenib and low-dose interferon alfa in patients with advanced renal cell carcinoma: clinical and biomarker analysis. Cancer. 2010;116:57–65.
CAS
PubMed
PubMed Central
Google Scholar
Busse A, Asemissen AM, Nonnenmacher A, Braun F, Ochsenreither S, Stather D, et al. Immunomodulatory effects of sorafenib on peripheral immune effector cells in metastatic renal cell carcinoma. Eur J Cancer. 2011;47:690.
Article
CAS
PubMed
Google Scholar
Desar IM, Jacobs JH, Hulsbergen-vandekaa CA, Oyen WJ, Mulders PF, van der Graaf WT, et al. Sorafenib reduces the percentage of tumour infiltrating regulatory T cells in renal cell carcinoma patients. Int J Cancer. 2011;129:507–12.
Article
CAS
PubMed
Google Scholar
Adachi M, Okayama Y, Akaza H, Yamanaka S. Safety and Efficacy of Sorafenib in Japanese Patients with Renal Cell Carcinoma under Daily Medical Practice: Result from the Post-Marketing All-Patient Surveillance with >3200 cases. Urology. 2012;80:s23–4.
Article
Google Scholar
Escudier B, Szczylik C, Hutson TE, Demkow T, Staehler M, Rolland F, et al. Randomized phase II trial of first-line treatment with sorafenib versus interferon Alfa-2a in patients with metastatic renal cell carcinoma. J Clin Oncol. 2009;27:1280–9.
Article
CAS
PubMed
Google Scholar