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  1. Ipilimumab has shown long-term overall survival (OS) in patients with advanced melanoma in clinical trials, but robust real-world evidence is lacking. We present long-term outcomes from the IMAGE study (NCT015...

    Authors: Stéphane Dalle, Laurent Mortier, Pippa Corrie, Michal Lotem, Ruth Board, Ana María Arance, Frank Meiss, Patrick Terheyden, Ralf Gutzmer, Brian Buysse, Kelly Oh, Jane Brokaw, T. Kim Le, Susan D. Mathias, Julie Scotto, Jennifer Lord-Bessen…
    Citation: BMC Cancer 2021 21:642
    Content type: Research article Published on:

  2. FoxP3+ Regulatory T cells (Tregs) and indoleamine-2,3-dioxygenase (IDO) participate in the formation of an immunosuppressive tumor microenvironment (TME) in malignant cutaneous melanoma (CM). Recent studies ha...

    Authors: Satu Salmi, Anton Lin, Benjamin Hirschovits-Gerz, Mari Valkonen, Niina Aaltonen, Reijo Sironen, Hanna Siiskonen and Sanna Pasonen-Seppänen
    Citation: BMC Cancer 2021 21:641
    Content type: Research article Published on:

  3. Although the National Comprehensive Cancer Network (NCCN) Guidelines recommend CCRT+AC and IC + CCRT as level 2A evidence for treatment of the locoregionally advanced NPC (II-IVa), IC + CCRT+AC could also be a...

    Authors: Wei Liu, Bolong Yu, Yunfan Luo, Junzheng Li, Xiaofei Yuan, Shuting Wu, Bijun Liang, Zehong Lv, Yanfei Li, Xinyu Peng, Juan Lu, Xiaohong Peng and Xiong Liu
    Citation: BMC Cancer 2021 21:639
    Content type: Research article Published on:

  4. The objectives of this study were to screen out cut-off age value and age-related differentially expressed genes (DEGs) in clear cell renal cell carcinoma (CCRCC) from Surveillance Epidemiology and End Results...

    Authors: Fucai Tang, Zechao Lu, Chengwu He, Hanbin Zhang, Weijia Wu and Zhaohui He
    Citation: BMC Cancer 2021 21:638
    Content type: Research article Published on:

  5. Pancreatic ductal adenocarcinoma (PDAC) patients suffer poor outcomes, including a five-year survival of below 10%. Poor outcomes result in part from therapeutic resistance that limits the impact of cytotoxic ...

    Authors: Ryne C. Ramaker, Andrew A. Hardigan, Emily R. Gordon, Carter A. Wright, Richard M. Myers and Sara J. Cooper
    Citation: BMC Cancer 2021 21:632
    Content type: Research Published on:

  6. Spatial inequalities in cancer management have been evidenced by studies reporting lower quality of care or/and lower survival for patients living in remote or socially deprived areas. NETSARC+ is a national r...

    Authors: Yohan Fayet, Raphaël Tétreau, Charles Honoré, Louis-Romée Le Nail, Cécile Dalban, François Gouin, Sylvain Causeret, Sophie Piperno-Neumann, Simone Mathoulin-Pelissier, Marie Karanian, Antoine Italiano, Loïc Chaigneau, Justine Gantzer, François Bertucci, Mickael Ropars, Esma Saada-Bouzid…
    Citation: BMC Cancer 2021 21:631
    Content type: Research Published on:

  7. No data exist for the long-term outcome of metastatic colorectal cancer (mCRC) from the Southern part of Asia. The primary objective of the study is to evaluate the survival outcome of mCRC from an Indian tert...

    Authors: Vinod Sharma, Atul Sharma, Vinod Raina, Deepak Dabkara, Bidhu Kalyan Mohanti, N. K. Shukla, Sushmita Pathy, Sanjay Thulkar, S. V. S. Deo, Sunil Kumar and Ranjit Kumar Sahoo
    Citation: BMC Cancer 2021 21:630
    Content type: Research Published on:

  8. Despite considerable medical proceedings, cancer is still a leading cause of death. Major problems for tumor therapy are chemoresistance as well as toxic side effects. In recent years, the additional treatment...

    Authors: Felix B. Meyer, Sophie Goebel, Sonja B. Spangel, Christiane Leovsky, Doerte Hoelzer and René Thierbach
    Citation: BMC Cancer 2021 21:629
    Content type: Research Published on:

  9. Oral Squamous Cell Carcinoma (OSCC) results from a series of genetic alteration in squamous cells. This particular type of cancer considers one of the most aggressive malignancies to control because of its fre...

    Authors: Koel Mukherjee, Debpali Sur, Abhijeet Singh, Sandhya Rai, Neeladrisingha Das, Rakshanya Sekar, Srinu Narindi, Vandana Kumar Dhingra, Bhinyaram Jat, K. V. Vinu Balraam, Satya Prakash Agarwal and Prabhat Kumar Mandal
    Citation: BMC Cancer 2021 21:628
    Content type: Research Published on:

  10. To explore the safety and effectiveness of delayed occlusion of the proximal inferior vena cava (DOPI) technique in retroperitoneal laparoscopic radical nephrectomy (LRN) and thrombectomy for renal tumor with ...

    Authors: Zhuo Liu, Peng Hong, Guodong Zhu, Li Zhang, Xun Zhao, Shiying Tang, Feilong Yang, Xiaojun Tian, Guoliang Wang, Shudong Zhang, Hongxian Zhang, Yi Huang, Chunxia Liu, Cheng Liu and Lulin Ma
    Citation: BMC Cancer 2021 21:627
    Content type: Research Published on:

  11. Lung cancer is one of the most lethal and most prevalent malignant tumors worldwide, and lung squamous cell carcinoma (LUSC) is one of the major histological subtypes. Although numerous biomarkers have been fo...

    Authors: Guichuan Huang, Jing Zhang, Ling Gong, Yi Huang and Daishun Liu
    Citation: BMC Cancer 2021 21:626
    Content type: Research article Published on:

  12. Newcastle disease virus (NDV) is an oncolytic virus with excellent selectivity against cancer cells, both in vitro and in vivo. Unfortunately, prolonged in vitro NDV infection results in the development of per...

    Authors: Lee-Chin Chan, Jeevanathan Kalyanasundram, Sze-Wei Leong, Mas Jaffri Masarudin, Abhi Veerakumarasivam, Khatijah Yusoff, Soon-Choy Chan and Suet-Lin Chia
    Citation: BMC Cancer 2021 21:625
    Content type: Research article Published on:

  13. Radical pancreaticoduodenectomy is the most common treatment strategy for patients diagnosed with adenocarcinoma of the pancreatic head. Few studies have reported the clinical characteristics and treatment eff...

    Authors: Chao Wu, Sheng Zhong Hou, Zuowei Wu, Xing Huang, Zihe Wang and Bole Tian
    Citation: BMC Cancer 2021 21:624
    Content type: Research article Published on:

  14. Rectal mucosal melanoma (RMM) is a rare and highly aggressive disease with a poor prognosis. Due to the rarity of RMM, there are few studies focusing on its genetic mechanism. This retrospective study aimed to...

    Authors: Huan Li, Lujing Yang, Yumei Lai, Xintong Wang, Xinyin Han, Siyao Liu, Dongliang Wang, Xiaojuan Li, Nana Hu, Yan Kong, Lu Si and Zhongwu Li
    Citation: BMC Cancer 2021 21:623
    Content type: Research Published on:

  16. Pegfilgrastim, a long-acting granulocyte colony-stimulating factor (G-CSF), is commonly used to prevent febrile neutropenia (FN), a potentially life-threatening complication, following myelosuppressive chemoth...

    Authors: Reshma Mahtani, Jeffrey Crawford, Sinéad M. Flannery, Tatiana Lawrence, Jennifer Schenfeld and Prasad L. Gawade
    Citation: BMC Cancer 2021 21:621
    Content type: Research article Published on:

  17. Treatments for soft tissue sarcoma (STS) include extensive surgical resection, radiation and chemotherapy, and can necessitate specialized care and excellent social support. Studies have demonstrated that soci...

    Authors: Boryana M. Eastman, Daniel S. Hippe, Landon S. Wootton, Matthew J. Nyflot, Matthew J. Thompson, Seth M. Pollack, Edward Kim and Matthew B. Spraker
    Citation: BMC Cancer 2021 21:620
    Content type: Research Published on:

  18. Mitochondrial fission regulator 2 (MTFR2) was involved in the progression and development of various cancers. However, the relationship between MTFR2 with lung adenocarcinoma (LUAD) had not been reported. Here...

    Authors: Cheng Chen, Yang Tang, Wen-Dong Qu, Xu Han, Jie-Bin Zuo, Qing-Yong Cai, Gang Xu, Yong-Xiang Song and Xi-Xian Ke
    Citation: BMC Cancer 2021 21:619
    Content type: Research Published on:

  19. CC chemokine receptor 4 (CCR4), the receptor for CCL22 and CCL17, is expressed on the surface of effector Tregs that have the highest suppressive effects on antitumor immune response. CCR4 is also widely expre...

    Authors: Ting Zhang, Jing Sun, Jinying Li, Yunuo Zhao, Tao Zhang, Ruoning Yang and Xuelei Ma
    Citation: BMC Cancer 2021 21:618
    Content type: Research article Published on:

  20. Lynch syndrome (LS) is an autosomal dominant hereditary cancer syndrome responsible for 2–4% of hereditary colorectal cancers (CRC). Mismatch repair protein deficiency (dMMR) is a characteristic feature of LS....

    Authors: Alice Talbot, Emily O’Donovan, Eileen Berkley, Carmel Nolan, Roisin Clarke and David Gallagher
    Citation: BMC Cancer 2021 21:617
    Content type: Research Published on:

  21. Lung adenocarcinoma (LAC) is the predominant histologic subtype of lung cancer and has a complicated pathogenesis with high mortality. The purpose of this study was to identify differentially expressed genes (...

    Authors: Mingze Lu, Xiaowen Fan, Weilin Liao, Yijiao Li, Lijie Ma, Mu Yuan, Rui Gu, Zhengdao Wei, Chao Wang and Hua Zhang
    Citation: BMC Cancer 2021 21:616
    Content type: Research article Published on:

  22. Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) remains a major public health problem and its pathogenesis remains unresolved. A recent proteomics study discovered a lipid enzyme Sterol O-acyltr...

    Authors: Yulong Chen, Xunjun Yang, Yao Chen, Guorong Chen, Cheryl A. Winkler, Ping An and Jianxin Lyu
    Citation: BMC Cancer 2021 21:615
    Content type: Research article Published on:

  24. This study aimed to describe the incidence, clinical characteristics, and prognosis of lung cancer patients with synchronous bone metastasis (SBM) and to analyze the prognostic factors of the lung cancer patie...

    Authors: Xu Guo, Wenjuan Ma, Haixiao Wu, Yao Xu, Dezheng Wang, Shuang Zhang, Zheng Liu, Vladimir P. Chekhonin, Karl Peltzer, Jin Zhang, Xin Wang and Chao Zhang
    Citation: BMC Cancer 2021 21:613
    Content type: Research Published on:

  25. The study aimed to investigate the potential benefit of more than 4 courses of S1 adjuvant chemotherapy for patients with pancreatic ductal adenocarcinoma (PDAC) after surgery.

    Authors: Bo Li, Shuo Shen, Siting You, Guoxiao Zhang, Suizhi Gao, Xiaohan Shi, Huan Wang, Xiaoyi Yin, Xiongfei Xu, Shiwei Guo and Gang Jin
    Citation: BMC Cancer 2021 21:612
    Content type: Research Published on:

  26. Pancreatic cancer (PC) is a major cause of cancer death. In an effort to improve treatment strategies and outcomes, DNA damage repair (DDR) pathways have been introduced as a new target in PC and in other canc...

    Authors: Ilario Giovanni Rapposelli, Valentina Zampiga, Ilaria Cangini, Valentina Arcangeli, Mila Ravegnani, Martina Valgiusti, Sara Pini, Stefano Tamberi, Giulia Bartolini, Alessandro Passardi, Giovanni Martinelli, Daniele Calistri, Giovanni Luca Frassineti, Fabio Falcini and Rita Danesi
    Citation: BMC Cancer 2021 21:611
    Content type: Research Published on:

  27. Few studies have examined prognostic outcomes-associated molecular signatures other than overall survival (OS) for gastric cancer (GC). We aimed to identify DNA methylation biomarkers associated with multiple ...

    Authors: Jin Dai, Akihiro Nishi, Zhe-Xuan Li, Yang Zhang, Tong Zhou, Wei-Cheng You, Wen-Qing Li and Kai-Feng Pan
    Citation: BMC Cancer 2021 21:610
    Content type: Research Published on:

  28. Increasing evidence indicates that site-distant metastases are associated with survival outcomes in patients with epithelial ovarian cancer. This study aimed to investigate the prognostic values of site-distan...

    Authors: Bo Wang, Shixuan Wang and Wu Ren
    Citation: BMC Cancer 2021 21:609
    Content type: Research article Published on:

  29. Long non-coding RNA (lncRNA) plays a critical role in the malignant progression of intrahepatic cholangiocarcinoma (iCCA). This study aimed to establish a 4-lncRNA prognostic signature and explore correspondin...

    Authors: Wenbo Zou, Zizheng Wang, Fei Wang, Lincheng Li, Rong Liu and Minggen Hu
    Citation: BMC Cancer 2021 21:608
    Content type: Research Published on:

  30. The nuclear phosphatase mitogen-activate protein kinase phosphatase-1 (MKP-1) is a key negative regulator of the innate immune response through the regulation of the biosynthesis of proinflammatory cytokines. ...

    Authors: Ahmed Hammad, Zhao-Hong Zheng, Akhileshwar Namani, Mohamed Elshaer, Xiu Jun Wang and Xiuwen Tang
    Citation: BMC Cancer 2021 21:607
    Content type: Research Published on:

  31. Multiple myeloma (MM) is a major health concern. Understanding the different burden and tendency of MM in different regions is crucial for formulating specific local strategies. Therefore, we evaluated the epi...

    Authors: Linghui Zhou, Qin Yu, Guoqing Wei, Linqin Wang, Yue Huang, Kejia Hu, Yongxian Hu and He Huang
    Citation: BMC Cancer 2021 21:606
    Content type: Research Published on:

  32. Anemia has been a known prognostic factor in metastatic hormone-sensitive prostate cancer (mHSPC). We therefore examined the effect of anemia on the efficacy of upfront abiraterone acetate (ABI) in patients wi...

    Authors: Teppei Okamoto, Daisuke Noro, Shingo Hatakeyama, Shintaro Narita, Koji Mitsuzuka, Toshihiko Sakurai, Sadafumi Kawamura, Senji Hoshi, Jiro Shimoda, Toshikazu Tanaka, Toshiaki Kawaguchi, Shigeto Ishidoya, Akihiro Ito, Norihiko Tsuchiya, Tomonori Habuchi and Chikara Ohyama
    Citation: BMC Cancer 2021 21:605
    Content type: Research article Published on:

  33. The dominant risk factor for urinary bladder cancer has been cigarette smoking, but, as smoking prevalence is decreasing in many populations, other risk factors may become uncovered. Such new risk factors coul...

    Authors: Kari Hemminki, Asta Försti, Akseli Hemminki, Börje Ljungberg and Otto Hemminki
    Citation: BMC Cancer 2021 21:604
    Content type: Research Published on:

  34. Almost one-third of patients with diffuse large B-cell lymphoma (DLBCL) cannot be cured with initial therapy and will eventually succumb to the disease. Further elaboration of prognostic markers of DLBCL will ...

    Authors: Tianjiao Tang, Jing Wang, Lidan Zhang, Ying Cheng, Laura Saleh, Yanni Gu and Hongbin Zhang
    Citation: BMC Cancer 2021 21:603
    Content type: Research article Published on:

  35. To compare the benefits and explore the cause of acquired resistance of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and its combination with chemotherapy in advanced non-small-cell lu...

    Authors: Qianqian Wang, Wen Gao, Fangyan Gao, Shidai Jin, Tianyu Qu, Fan Lin, Chen Zhang, Jingya Zhang, Zhihong Zhang, Liang Chen and Renhua Guo
    Citation: BMC Cancer 2021 21:602
    Content type: Research article Published on:

  36. Chemotherapy induced nausea- vomiting (CINV) is considered as the most common, feared and most troublesome side effect of chemotherapy. NEPA (NEtupitant 300 mg + PAlonosetron 0.50 mg) is the first commercially...

    Authors: Bharat Vaswani, Palanki Satya Dattatreya, Sagar Bhagat, Saiprasad Patil and Hanmant Barkate
    Citation: BMC Cancer 2021 21:601
    Content type: Research article Published on:

  37. Malignant tumor is one of the most serious diseases endangering human health. Circular RNAs play an important role in the tumorigenesis and progression of various malignant tumors. Although various studies hav...

    Authors: Fan Chao, Shiyu Wang, Cong Zhang, Dunsheng Han, Zhe Ma and Gang Chen
    Citation: BMC Cancer 2021 21:600
    Content type: Research article Published on:

  38. The potential reversibility of aberrant DNA methylation indicates an opportunity for oncotherapy. This study aimed to integrate methylation-driven genes and pretreatment prognostic factors and then construct a...

    Authors: Dongsheng He, Shengyin Liao, Lifang Cai, Weiming Huang, Xuehua Xie and Mengxing You
    Citation: BMC Cancer 2021 21:599
    Content type: Research article Published on:

  39. The influence of lymph node dissection (LND) on survival in patients with head and neck neurogenic tumors remains unclear. We aimed to determine the effect of LND on the outcomes of patients with head and neck...

    Authors: Xiaolian Fang, Shengcai Wang, Junyang Zhao, Yamei Zhang, Jie Zhang, Yanzhen Li, Xiaodan Li, Jun Tai and Xin Ni
    Citation: BMC Cancer 2021 21:598
    Content type: Research article Published on:

  40. Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are heterogeneous neoplasms. Although some have a relatively benign and indolent natural history, others can be aggressive and ultimately fatal. Somatost...

    Authors: Sheila D. Rustgi, Aaron Oh, Jeong Yun Yang, Dasol Kang, Edward Wolin, Chung Y. Kong, Chin Hur and Michelle K. Kim
    Citation: BMC Cancer 2021 21:597
    Content type: Research article Published on:

  41. Phosphorylation of NF-kappaB inhibitor alpha (IκBα) is key to regulation of NF-κB transcription factor activity in the cell. Several sites of IκBα phosphorylation by members of the IκB kinase family have been ...

    Authors: Sung Hoon Choi, Hee-Sub Yoon, Shin-Ae Yoo, Sung Ho Yun, Joo-Hee Park, Eun Hee Han, Sung-Gil Chi and Young-Ho Chung
    Citation: BMC Cancer 2021 21:596
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2021 21:1198

  44. ATLAS evaluated the efficacy and safety of the PARP inhibitor rucaparib in patients with previously treated locally advanced/unresectable or metastatic urothelial carcinoma (UC).

    Authors: P. Grivas, Y. Loriot, R. Morales-Barrera, M. Y. Teo, Y. Zakharia, S. Feyerabend, N. J. Vogelzang, E. Grande, N. Adra, A. Alva, A. Necchi, A. Rodriguez-Vida, S. Gupta, D. H. Josephs, S. Srinivas, K. Wride…
    Citation: BMC Cancer 2021 21:593
    Content type: Research article Published on:

  45. There are limited data concerning patients treated with sequential bilateral kidney surgery. Current guidelines still lack an optimal surgical sequencing approach. We evaluated renal functional outcomes after ...

    Authors: Jung Kwon Kim, Hwanik Kim, Hakmin Lee, Jong Jin Oh, Sangchul Lee, Sung Kyu Hong, Cheol Kwak and Seok-Soo Byun
    Citation: BMC Cancer 2021 21:592
    Content type: Research Published on:

  46. Blood type has been associated with the risk of gastric cancer, but few studies have examined the association with esophageal squamous cell carcinoma (ESCC).

    Authors: Yingxi Chen, Nan Hu, Linda Liao, Kai Yu, Xiao-Ou Shu, Wei Zheng, Jian-Min Yuan, Woon-Puay Koh, You-Lin Qiao, Jin-Hu Fan, Sanford M. Dawsey, Neal D. Freedman, Philip R. Taylor, Alisa M. Goldstein and Christian C. Abnet
    Citation: BMC Cancer 2021 21:589
    Content type: Research article Published on:

  47. A self-help workbook is expected to support cancer patients to cope with physical and psychosocial distress, to facilitate communication with medical staff, and to improve quality of life (QOL). We conducted a...

    Authors: Toshimi Takano, Ayako Matsuda, Noriko Ishizuka, Yukinori Ozaki, Koichi Suyama, Yuko Tanabe, Yuji Miura and Eisuke Matsushima
    Citation: BMC Cancer 2021 21:588
    Content type: Research article Published on:

  49. Research investigating exercise interventions in oesophagogastric cancer survivors is sparse, and the outcomes are varied. The aim of this systematic review is to identify the domains and outcomes reported in ...

    Authors: Louise O’Connor, Emily Smyth, Annemarie E. Bennett, Valerie Smith, Linda O’Neill, John V. Reynolds, Juliette Hussey and Emer Guinan
    Citation: BMC Cancer 2021 21:586
    Content type: Research article Published on:

  50. Radiation-induced pneumonitis (RP) is a non-negligible and sometimes life-threatening complication among patients with thoracic radiation. We initially aimed to ascertain the predictive value of acute radiatio...

    Authors: Wenjie Tang, Xiaolin Li, Haining Yu, Xiaoyang Yin, Bing Zou, Tingting Zhang, Jinlong Chen, Xindong Sun, Naifu Liu, Jinming Yu and Peng Xie
    Citation: BMC Cancer 2021 21:585
    Content type: Research article Published on:

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