Barta JA, Powell CA, Wisnivesky JP. Global epidemiology of lung Cancer. Ann Global Health. 2019;85(1):8. https://doi.org/10.5334/aogh.2419.
Article
Google Scholar
Liu B, Quan X, Xu C, Lv J, Li C, Dong L, et al. Lung cancer in young adults aged 35 years or younger: a full-scale analysis and review. J Cancer. 2019;10(15):3553–9. https://doi.org/10.7150/jca.27490.
Article
PubMed
PubMed Central
Google Scholar
Li J, Yang F, Li X, Zhang M, Fu R, Yin X, et al. Characteristics, survival, and risk factors of Chinese young lung cancer patients: the experience from two institutions. Oncotarget. 2017;8(51):89236–44. https://doi.org/10.18632/oncotarget.19183.
Article
PubMed
PubMed Central
Google Scholar
Travis WD, Brambilla E, Noguchi M, Nicholson AG, Geisinger KR, Yatabe Y, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thorac Oncol. 2011;6(2):244–85. https://doi.org/10.1097/JTO.0b013e318206a221.
Article
PubMed
PubMed Central
Google Scholar
Barletta JA, Yeap BY, Chirieac LR. Prognostic significance of grading in lung adenocarcinoma. Cancer. 2010;116(3):659–69. https://doi.org/10.1002/cncr.24831.
Article
PubMed
Google Scholar
Alberg AJ, Brock MV, Ford JG, Samet JM, Spivack SD. Epidemiology of lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e1S–e29S. https://doi.org/10.1378/chest.12-2345.
Article
CAS
PubMed
PubMed Central
Google Scholar
Araki K, Osaki M, Nagahama Y, Hiramatsu T, Nakamura H, Ohgi S, et al. Expression of RUNX3 protein in human lung adenocarcinoma: implications for tumor progression and prognosis. Cancer Sci. 2005;96(4):227–31. https://doi.org/10.1111/j.1349-7006.2005.00033.x.
Article
CAS
PubMed
Google Scholar
Nose N, Sugio K, Oyama T, Nozoe T, Uramoto H, Iwata T, et al. Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung. J Clin Oncol. 2009;27(3):411–7. https://doi.org/10.1200/JCO.2008.18.3251.
Article
CAS
PubMed
Google Scholar
Minamiya Y, Saito H, Takahashi N, Ito M, Imai K, Ono T, et al. Expression of the chemokine receptor CXCR4 correlates with a favorable prognosis in patients with adenocarcinoma of the lung. Lung Cancer. 2010;68(3):466–71. https://doi.org/10.1016/j.lungcan.2009.07.015.
Article
PubMed
Google Scholar
Minamiya Y, Saito H, Takahashi N, Ito M, Toda H, Ono T, et al. Expression of the chemokine receptor CCR6 correlates with a favorable prognosis in patients with adenocarcinoma of the lung. Tumour Biol. 2011;32(1):197–202. https://doi.org/10.1007/s13277-010-0113-x.
Article
CAS
PubMed
Google Scholar
Yamaguchi E, Nakayama T, Nanashima A, Matsumoto K, Yasutake T, Sekine I, et al. Ets-1 proto-oncogene as a potential predictor for poor prognosis of lung adenocarcinoma. Tohoku J Exp Med. 2007;213(1):41–50. https://doi.org/10.1620/tjem.213.41.
Article
CAS
PubMed
Google Scholar
DiFeo A, Feld L, Rodriguez E, Wang C, Beer DG, Martignetti JA, et al. A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response. Cancer Res. 2008;68(4):965–70. https://doi.org/10.1158/0008-5472.CAN-07-2604.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang R, Geng J, Wang JH, Chu XY, Geng HC, Chen LB. Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma. Lung Cancer. 2009;66(2):237–44. https://doi.org/10.1016/j.lungcan.2009.02.001.
Article
PubMed
Google Scholar
Nakai R, Maniwa Y, Tanaka Y, Nishio W, Yoshimura M, Okita Y, et al. Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma. Cancer Sci. 2010;101(5):1326–30. https://doi.org/10.1111/j.1349-7006.2010.01530.x.
Article
CAS
PubMed
Google Scholar
Minamiya Y, Ono T, Saito H, Takahashi N, Ito M, Mitsui M, et al. Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung. Lung Cancer. 2011;74(2):300–4. https://doi.org/10.1016/j.lungcan.2011.02.019.
Article
PubMed
Google Scholar
Minamiya Y, Ono T, Saito H, Takahashi N, Ito M, Motoyama S, et al. Strong expression of HDAC3 correlates with a poor prognosis in patients with adenocarcinoma of the lung. Tumour Biol. 2010;31(5):533–9. https://doi.org/10.1007/s13277-010-0066-0.
Article
CAS
PubMed
Google Scholar
Wu X, Zang W, Cui S, Wang M. Bioinformatics analysis of two microarray gene-expression data sets to select lung adenocarcinoma marker genes. Eur Rev Med Pharmacol Sci. 2012;16(11):1582–7.
CAS
PubMed
Google Scholar
Dogan S, Shen R, Ang DC, Johnson ML, D'Angelo SP, Paik PK, et al. Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers. Clin Cancer Res. 2012;18(22):6169–77. https://doi.org/10.1158/1078-0432.CCR-11-3265.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ou SH. Lung cancer in never-smokers. Does smoking history matter in the era of molecular diagnostics and targeted therapy? J Clin Pathol. 2013;66(10):839–46. https://doi.org/10.1136/jclinpath-2012-201296.
Article
PubMed
Google Scholar
Feng H, Gu Z-Y, Li Q, Liu Q-H, Yang X-Y, Zhang J-J. Identification of significant genes with poor prognosis in ovarian cancer via bioinformatical analysis. J Ovar Res. 2019;12(1):35. https://doi.org/10.1186/s13048-019-0508-2.
Article
Google Scholar
Davis S, Meltzer PS. GEOquery: a bridge between the gene expression omnibus (GEO) and BioConductor. Bioinformatics. 2007;23(14):1846–7. https://doi.org/10.1093/bioinformatics/btm254.
Article
CAS
PubMed
Google Scholar
da Huang W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009;4(1):44–57.
Article
CAS
Google Scholar
Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000;25(1):25–9. https://doi.org/10.1038/75556.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kanehisa M, Goto S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000;28(1):27–30. https://doi.org/10.1093/nar/28.1.27.
Article
CAS
PubMed
PubMed Central
Google Scholar
Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, et al. STRING v10: protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015;43(Database issue):D447–52. https://doi.org/10.1093/nar/gku1003.
Article
CAS
PubMed
Google Scholar
Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 2003;13(11):2498–504. https://doi.org/10.1101/gr.1239303.
Article
CAS
PubMed
PubMed Central
Google Scholar
Nagy A, Lanczky A, Menyhart O, Gyorffy B. Validation of miRNA prognostic power in hepatocellular carcinoma using expression data of independent datasets. Sci Rep. 2018;8(1):9227. https://doi.org/10.1038/s41598-018-27521-y.
Article
CAS
PubMed
PubMed Central
Google Scholar
Tang Z, Li C, Kang B, Gao G, Li C, Zhang Z. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98–W102. https://doi.org/10.1093/nar/gkx247.
Article
CAS
PubMed
PubMed Central
Google Scholar
Puffenberger EG, Hosoda K, Washington SS, Nakao K, de Wit D, Yanagisawa M, et al. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell. 1994;79(7):1257–66. https://doi.org/10.1016/0092-8674(94)90016-7.
Article
CAS
PubMed
Google Scholar
Eberle J, Weitmann S, Thieck O, Pech H, Paul M, Orfanos CE. Downregulation of endothelin B receptor in human melanoma cell lines parallel to differentiation genes. J Invest Dermatol. 1999;112(6):925–32. https://doi.org/10.1046/j.1523-1747.1999.00598.x.
Article
CAS
PubMed
Google Scholar
Chen SC, Lin CY, Chen YH, Fang HY, Cheng CY, Chang CW, et al. Aberrant promoter methylation of EDNRB in lung cancer in Taiwan. Oncol Rep. 2006;15(1):167–72.
PubMed
Google Scholar
Shi K, Chen X, Xie B, Yang SS, Liu D, Dai G, et al. Celastrol alleviates chronic obstructive pulmonary disease by inhibiting cellular inflammation induced by cigarette smoke via the Ednrb/Kng1 signaling pathway. Front Pharmacol. 2018;9:1276. https://doi.org/10.3389/fphar.2018.01276.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, et al. Activation of orphan receptors by the hormone relaxin. Science. 2002;295(5555):671–4. https://doi.org/10.1126/science.1065654.
Article
CAS
PubMed
Google Scholar
Feng S, Bogatcheva NV, Kamat AA, Agoulnik AI. Genetic targeting of relaxin and insl3 signaling in mice. Ann N Y Acad Sci. 2005;1041(1):82–90. https://doi.org/10.1196/annals.1282.012.
Article
CAS
PubMed
Google Scholar
Samuel CS, Royce SG, Chen B, Cao H, Gossen JA, Tregear GW, et al. Relaxin family peptide receptor-1 protects against airway fibrosis during homeostasis but not against fibrosis associated with chronic allergic airways disease. Endocrinology. 2009;150(3):1495–502. https://doi.org/10.1210/en.2008-1062.
Article
CAS
PubMed
Google Scholar
Tan J, Tedrow JR, Dutta JA, Juan-Guardela B, Nouraie M, Chu Y, et al. Expression of RXFP1 is decreased in idiopathic pulmonary fibrosis. Implications for Relaxin-based therapies. Am J Respir Crit Care Med. 2016;194(11):1392–402. https://doi.org/10.1164/rccm.201509-1865OC.
Article
CAS
PubMed
PubMed Central
Google Scholar
Metheny-Barlow LJ, Li LY. The enigmatic role of angiopoietin-1 in tumor angiogenesis. Cell Res. 2003;13(5):309–17. https://doi.org/10.1038/sj.cr.7290176.
Article
CAS
PubMed
Google Scholar
Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, et al. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell. 1996;87(7):1171–80. https://doi.org/10.1016/S0092-8674(00)81813-9.
Article
CAS
PubMed
Google Scholar
Wong MP, Chan SY, Fu KH, Leung SY, Cheung N, Yuen ST, et al. The angiopoietins, tie2 and vascular endothelial growth factor are differentially expressed in the transformation of normal lung to non-small cell lung carcinomas. Lung Cancer. 2000;29(1):11–22. https://doi.org/10.1016/S0169-5002(00)00118-5.
Article
CAS
PubMed
Google Scholar
Park JH, Choi H, Kim YB, Kim YS, Sheen SS, Choi JH, et al. Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer. Lung Cancer. 2009;66(3):359–64. https://doi.org/10.1016/j.lungcan.2009.03.002.
Article
PubMed
Google Scholar
Yao S, Dong SS, Ding JM, Rong Y, Zhang YJ, Chen H, et al. Sex-specific SNP-SNP interaction analyses within topologically associated domains reveals ANGPT1 as a novel tumor suppressor gene for lung cancer. Genes Chromosom Cancer. 2019;59(1):13–22. https://doi.org/10.1002/gcc.22793.
Article
CAS
Google Scholar
Tan Y, Zhang T, Zhou L, Liu S, Liang C. MiR-34b-3p represses the multidrug-Chemoresistance of bladder Cancer cells by regulating the CCND2 and P2RY1 genes. Med Sci Monit:1323–35. https://doi.org/10.12659/MSM.913746.
Light KC, Agarwal N, Iacob E, White AT, Kinney AY, VanHaitsma TA, et al. Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome. Psychoneuroendocrinology. 2013;38(12):2983–95. https://doi.org/10.1016/j.psyneuen.2013.08.008.
Article
CAS
PubMed
Google Scholar
Angenendt L, Bormann E, Pabst C, Alla V, Gorlich D, Braun L, et al. The neuropeptide receptor calcitonin receptor-like (CALCRL) is a potential therapeutic target in acute myeloid leukemia. Leukemia. 2019;33(12):2830–41. https://doi.org/10.1038/s41375-019-0505-x.
Article
CAS
PubMed
Google Scholar