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  1. Cancer-related fatigue (CRF) is the most common side effect of cancer and cancer treatment. CRF prevalence is up to 50% in breast cancer patients and can continue several years after cancer remission. This per...

    Authors: M. Chartogne, A. Leclercq, B. Beaune, S. Boyas, C. Forestier, T. Martin, V. Thomas-Ollivier, S. Landry, H. Bourgeois, O. Cojocarasu, V. Pialoux, O. Zanna, L. A. Messonnier, A. Rahmani and B. Morel
    Citation: BMC Cancer 2021 21:1140
  2. Clear cell renal cell carcinoma (ccRCC) is one of the most lethal urological malignancies, but the pathogenesis and prognosis of ccRCC remain obscure, which need to be better understand.

    Authors: Yang Dong, Wei-ming Ma, Wen Yang, Lin Hao, Shao-qi Zhang, Kun Fang, Chun-hui Hu, Qian-jin Zhang, Zhen-duo Shi, Wen-da Zhang, Tao Fan, Tian Xia and Cong-hui Han
    Citation: BMC Cancer 2021 21:1135
  3. Signaling through VEGF/VEGFR induces cancer angiogenesis and affects immune cells. An increasing number of studies have recently focused on combining anti-VEGF/VEGFR agents and immune checkpoint inhibitors (IC...

    Authors: Liting Xue, Xingyuan Gao, Haoyu Zhang, Jianxing Tang, Qian Wang, Feng Li, Xinxin Li, Xiaohong Yu, Zhihong Lu, Yue Huang, Renhong Tang and Wenqing Yang
    Citation: BMC Cancer 2021 21:1134
  4. Virtual reality (VR) enables data visualization in an immersive and engaging manner, and it can be used for creating ways to explore scientific data. Here, we use VR for visualization of 3D histology data, cre...

    Authors: Kaisa Liimatainen, Leena Latonen, Masi Valkonen, Kimmo Kartasalo and Pekka Ruusuvuori
    Citation: BMC Cancer 2021 21:1133
  5. Locally recurrent rectal cancer (LRRC) remains a major problem after curative resection of primary rectal cancer. A noninvasive, prognostic biomarker with which to accurately evaluate disease status and assess...

    Authors: Mamoru Uemura, Masataka Ikeda, Rio Handa, Katsuki Danno, Junichi Nishimura, Taishi Hata, Ichiro Takemasa, Tsunekazu Mizushima, Hirofumi Yamamoto, Mitsugu Sekimoto, Yuichiro Doki and Hidetoshi Eguchi
    Citation: BMC Cancer 2021 21:1132
  6. The V-Akt murine thymoma viral oncogene (AKT) 1 (E17K) is a subfamily of serine/threonine protein kinases that affects the survival, proliferation, and invasion of cancer cells. The clinicopathological features a...

    Authors: Tatsunori Shimoi, Jun Hashimoto, Kazuki Sudo, Akihiko Shimomura, Emi Noguchi, Chikako Shimizu, Mayu Yunokawa, Kan Yonemori, Hiroshi Yoshida, Masayuki Yoshida, Tomoyasu Kato, Takayuki Kinoshita, Takahiro Fukuda, Yasuhiro Fujiwara and Kenji Tamura
    Citation: BMC Cancer 2021 21:1131
  7. To aid clinicians strategizing treatment for upper esophageal squamous cell carcinoma (ESCC), this retrospective study investigated associations between primary gross tumor volume (GTVp) and prognosis in patie...

    Authors: Yuanmei Chen, Qiuyuan Huang, Junqiang Chen, Yu Lin, Xinyi Huang, Qifeng Wang, Yong Yang, Bijuan Chen, Yuling Ye, Binglin Zheng, Rong Qi, Yushan Chen and Yuanji Xu
    Citation: BMC Cancer 2021 21:1130
  8. The body mass index (BMI) is commonly used as a simple indicator of obesity; patients with early-stage breast cancer who are obese (OB) per BMI measurements have been shown to have high postoperative recurrenc...

    Authors: Koji Takada, Shinichiro Kashiwagi, Yuka Asano, Wataru Goto, Sae Ishihara, Tamami Morisaki, Masatsune Shibutani, Hiroaki Tanaka, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2021 21:1129
  9. Clinically, the coadministration of opioids to enhance antinociception and decrease tolerance has attracted increasing research attention. We investigated the effects of dezocine, a mu- and kappa-opioid recept...

    Authors: Lin-xin Wu, Yan-peng Dong, Qian-mei Zhu, Bo Zhang, Bo-lun Ai, Tao Yan, Guo-hua Zhang and Li Sun
    Citation: BMC Cancer 2021 21:1128
  10. Caregivers are invaluable sources of support for individuals recovering from head and neck cancer (HNC). Accordingly, minimizing caregiver distress is essential to promote the well-being of both caregivers and...

    Authors: Zachary M. Kassir, Jinhong Li, Christine Harrison, Jonas T. Johnson and Marci L. Nilsen
    Citation: BMC Cancer 2021 21:1127
  11. Not all patients with unresectable hepatocellular carcinoma (uHCC) benefit from treatment with immune checkpoint inhibitors and molecular-targeted agents. The aim of this retrospective study was to assess the ...

    Authors: Song Chen, Bo Xu, Zhiqiang Wu, Pengfei Wang, Weiguang Yu, Zhiyong Liu, Xiaoyong Huang, Yanqing Wu, Tengfei Li and Wenbo Guo
    Citation: BMC Cancer 2021 21:1126
  12. Low- and middle-income countries (LMICs) experienced increasing rates of colorectal cancer (CRC) incidence in the last decade and lower 5-year survival rates compared to high-income countries (HICs) where the ...

    Authors: Désirée Schliemann, Kogila Ramanathan, Nicholas Matovu, Ciaran O’Neill, Frank Kee, Tin Tin Su and Michael Donnelly
    Citation: BMC Cancer 2021 21:1125
  13. Different pathological subtypes of invasive pulmonary adenocarcinoma (IPA) have different surgical methods and heterogeneous prognosis. It is essential to clarify IPA subtypes before operation and high-resolut...

    Authors: Pengju Zhang, Tianran Li, Xuemin Tao, Xin Jin and Shaohong Zhao
    Citation: BMC Cancer 2021 21:1124
  14. Favorable survival in malignant cutaneous melanoma (melanoma) has increased the likelihood of second primary cancer (SPC). We assess the influence of patient characteristics at diagnosis of first melanoma and ...

    Authors: Guoqiao Zheng, Subhayan Chattopadhyay, Kristina Sundquist, Jan Sundquist, Asta Försti, Akseli Hemminki and Kari Hemminki
    Citation: BMC Cancer 2021 21:1123
  15. Actinomycin-D (Act-D) and Methotrexate (MTX) are both effective first-line agents for low-risk gestational trophoblastic neoplasia (LRGTN) with no consensus regarding which is more effective or less toxic. The...

    Authors: Jiatao Hao, Weihua Zhou, Mengzhao Zhang, Hui Yu, Taohong Zhang, Ruifang An and Yan Xue
    Citation: BMC Cancer 2021 21:1122
  16. Synchronous oligometastatic non-small cell lung cancer (NSCLC) is generally characterised by the limited number of metastases at the time of diagnosis. Several clinical trials have shown that local ablative th...

    Authors: Taichi Miyawaki, Hirotsugu Kenmotsu, Hideyuki Harada, Yasuhisa Ohde, Yasutaka Chiba, Koji Haratani, Tamio Okimoto, Tomohiro Sakamoto, Kazushige Wakuda, Kentaro Ito, Takehiro Uemura, Shinya Sakata, Yoshihito Kogure, Yasumasa Nishimura, Kazuhiko Nakagawa and Nobuyuki Yamamoto
    Citation: BMC Cancer 2021 21:1121
  17. We investigated the performance improvement of physicians with varying levels of chest radiology experience when using a commercially available artificial intelligence (AI)-based computer-assisted detection (C...

    Authors: Daiju Ueda, Akira Yamamoto, Akitoshi Shimazaki, Shannon Leigh Walston, Toshimasa Matsumoto, Nobuhiro Izumi, Takuma Tsukioka, Hiroaki Komatsu, Hidetoshi Inoue, Daijiro Kabata, Noritoshi Nishiyama and Yukio Miki
    Citation: BMC Cancer 2021 21:1120
  18. Previous studies have observed a close association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) as well as extrahepatic cancers. However, research concerning the effect of HBV i...

    Authors: Tong Liu, Wenqiang Li, Youcheng Zhang, Sarah Tan Siyin, Qi Zhang, Mengmeng Song, Kangping Zhang, Siqing Liu and Hanping Shi
    Citation: BMC Cancer 2021 21:1119
  19. Breast cancer chemoresistance is attributed to a wide variety of mechanisms, including autophagy. Transcription factor EB (TFEB) has been recently identified and characterized as one major regulator of autopha...

    Authors: Serena Bertozzi, Ambrogio P. Londero, Luigi Viola, Maria Orsaria, Michela Bulfoni, Stefania Marzinotto, Bruna Corradetti, Umberto Baccarani, Daniela Cesselli, Carla Cedolini and Laura Mariuzzi
    Citation: BMC Cancer 2021 21:1118
  20. Preoperative serum gamma-glutamyl transferase (γ-GT) levels is significantly related to the prognosis of hepatocellular carcinoma (HCC), but its clinical value in the management of postoperative adjuvant trans...

    Authors: Qiao Ke, Fu Xiang, Chunhong Xiao, Qizhen Huang, Xiaolong Liu, Yongyi Zeng, Lei Wang and Jingfeng Liu
    Citation: BMC Cancer 2021 21:1117
  21. Abdominal computed tomography (CT) is the standard imaging method for patients with suspected colorectal liver metastases (CRLM) in the diagnostic workup for surgery or thermal ablation. Diffusion-weighted and...

    Authors: B. Görgec, I. Hansen, G. Kemmerich, T. Syversveen, M. Abu Hilal, E. J. T. Belt, R. H. C. Bisschops, T. L. Bollen, K. Bosscha, M. C. Burgmans, V. Cappendijk, M. T. De Boer, M. D’Hondt, B. Edwin, H. Gielkens, D. J. Grünhagen…
    Citation: BMC Cancer 2021 21:1116
  22. Correct preoperative estimation of the malignant extent is crucial for optimal planning of breast cancer surgery. The sensitivity of mammography is lower in dense breasts, and additional imaging techniques are...

    Authors: Kristina Åhsberg, Anna Gardfjell, Emma Nimeus, Lisa Ryden and Sophia Zackrisson
    Citation: BMC Cancer 2021 21:1115
  23. Today, cancer ranks as one of the leading causes of death. Despite the large number of novel available therapies, radiotherapy (RT) remains as the most effective non-surgical method to cure cancer patients. In...

    Authors: Tomás Merino, Mauricio P. Pinto, María Paz Orellana, Gonzalo Martinez, Marcelo Andía, Pablo Munoz-Schuffenegger, Francisco Acevedo, Luigi Gabrielli, Cesar Sanchez and Jaime Pereira
    Citation: BMC Cancer 2021 21:1114
  24. The outcome of patients with muscle-invasive bladder cancer (MIBC) remains poor, despite aggressive treatments. Inadequate primary staging, classically performed by computed tomography (CT)-imaging, could lead...

    Authors: Flor Verghote, Lindsay Poppe, Sofie Verbeke, Piet Dirix, Maarten Albersen, Gert De Meerleer, Charlien Berghen, Piet Ost, Geert Villeirs, Pieter De Visschere, Kathia De Man, Daan De Maeseneer, Sylvie Rottey, Charles Van Praet, Karel Decaestecker and Valérie Fonteyne
    Citation: BMC Cancer 2021 21:1113
  25. Tumor cells exhibit enhanced metabolism of nutrients to satisfy the demand of sustained proliferation in vivo. Seminal reports have presented evidence that tryptophan (Trp) metabolic reprogramming induced by a...

    Authors: Fan Li, Zhenyu Zhao, Zongbiao Zhang, Yan Zhang and Wei Guan
    Citation: BMC Cancer 2021 21:1112
  26. Among patients with colorectal cancer (CRC) treated with oxaliplatin (L-OHP)-based chemotherapy, delayed chemotherapy-induced nausea and vomiting (CINV) have not been well controlled.

    Authors: Mototsugu Shimokawa, Toshinobu Hayashi, Junichi Nishimura, Taroh Satoh, Mutsumi Fukunaga, Reiko Matsui, Yasushi Tsuji, Fumitaka Mizuki and Takahiro Kogawa
    Citation: BMC Cancer 2021 21:1111
  27. As patients with cervical cancer and precancerous lesions can be diagnosed at early stage and live longer, it is imperative to understand their health-related quality of life so that better cancer-related poli...

    Authors: Min Zhao, Xin Pu, Yi Jun Yan, Shao Zhang, Xue Long, Lei Luo and Zheng Li
    Citation: BMC Cancer 2021 21:1110
  28. The effect of dairy products intake on breast cancer (BC) is highly controversial. This study aims to investigate the relationship between dairy intake and BC incidence.

    Authors: Yujing He, Qinghua Tao, Feifei Zhou, Yuexiu Si, Rongrong Fu, Binbin Xu, Jiaxuan Xu, Xiangyuan Li and Bangsheng Chen
    Citation: BMC Cancer 2021 21:1109
  29. Diffuse gliomas are the most common malignant tumors of the central nervous system with poor treatment efficacy. Infiltration of immune cells into tumors during immunosurveillance is observed in multiple tumor...

    Authors: Constanze L. Kemmerer, Jens Schittenhelm, Evelyn Dubois, Laura Neumann, Lisa M. Häsler, Marius Lambert, Mirjam Renovanz, Stephan A. Kaeser, Ghazaleh Tabatabai, Ulf Ziemann, Ulrike Naumann and Markus C. Kowarik
    Citation: BMC Cancer 2021 21:1108
  30. EGFR and ALK alternations often contribute to human malignancies, including lung cancer. EGFR and ALK mutations are usually sensitive to EGFR-tyrosine kinase inhibitors (TKIs) and ALK-TKIs. Although generally ...

    Authors: Xiaodan Yang, Jia Zhong, Zhuo Yu, Minglei Zhuo, Min Zhang, Rongrong Chen, Xuefeng Xia and Jun Zhao
    Citation: BMC Cancer 2021 21:1107
  31. Body mass index (BMI), waist and hip circumference are strongly correlated and do not reflect body composition. A Body Shape Index (ABSI) and Hip Index (HI) define waist and hip size among individuals with the...

    Authors: Sofia Christakoudi, Konstantinos K. Tsilidis, Evangelos Evangelou and Elio Riboli
    Citation: BMC Cancer 2021 21:1106
  32. The current standard treatment for elderly patients with newly diagnosed glioblastoma is surgery followed by short-course radiotherapy with temozolomide. In recent studies, 40 Gy in 15 fractions vs. 60 Gy in 3...

    Authors: Yoshiki Arakawa, Keita Sasaki, Yohei Mineharu, Megumi Uto, Takashi Mizowaki, Junki Mizusawa, Yuta Sekino, Tomohiro Ono, Hidefumi Aoyama, Kaishi Satomi, Koichi Ichimura, Manabu Kinoshita, Makoto Ohno, Yoshinori Ito, Ryo Nishikawa, Haruhiko Fukuda…
    Citation: BMC Cancer 2021 21:1105
  33. While underlying mechanisms and pathways of social inequalities in cancer survival have been extensively examined in adults, this is less so for children with cancer. Hypothesized mechanisms include prediagnos...

    Authors: Line Hjøllund Pedersen, Friederike Erdmann, Gitte Lerche Aalborg, Lisa Lyngsie Hjalgrim, Hanne Bækgaard Larsen, Kjeld Schmiegelow, Jeanette Falck Winther and Susanne Oksbjerg Dalton
    Citation: BMC Cancer 2021 21:1104
  34. Low-level viremia generally refers to detectable HBV DNA levels lower than 2000 IU/mL. Studies show that low-level viremia is a risk factor for hepatocellular carcinoma. The aim of this study was to explore th...

    Authors: Furong Sun, Zhifei Liu and Bingyuan Wang
    Citation: BMC Cancer 2021 21:1103
  35. Cervical cancer is the second commonly diagnosed cancer and the second leading cause of cancer death in women in Ethiopia, with rates among the highest worldwide. However, there are limited data on cervical ca...

    Authors: Biniyam Tefera Deressa, Mathewos Assefa, Ephrem Tafesse, Eva Johanna Kantelhardt, Ivan Soldatovic, Nikola Cihoric, Daniel Rauch and Ahmedin Jemal
    Citation: BMC Cancer 2021 21:1102
  36. Bortezomib (BZM), alone or in combination with other chemotherapies, has displayed strong anticancer effects in several cancers. The efficacy of the combination of BZM and mitoxantrone (MTX) in treating prosta...

    Authors: Ying Zhang, Qiuzi Liu, Wei Wei, Guoan Zhang, Siyuan Yan, Rongrong Dai, Ying Sun, Dubo Su, Shun Lv, Yong Xia, Jing Li and Changlin Li
    Citation: BMC Cancer 2021 21:1101
  37. Swallowing therapy is commonly provided as a treatment to lessen the risk or severity of dysphagia secondary to radiotherapy (RT) for head and neck cancer (HNC); however, best practice is not yet established. ...

    Authors: R. Martino, M. I. Fitch, C. D. Fuller, A. Hope, G. Krisciunas, S. E. Langmore, C. Lazarus, C. L. Macdonald, T. McCulloch, G. Mills, D. A. Palma, K. Pytynia, J. Ringash, K. Sultanem, J. Theurer, K. E. Thorpe…
    Citation: BMC Cancer 2021 21:1100
  38. Implementing genetic testing for inherited cancer predisposition into routine clinical care offers a tremendous opportunity for cancer prevention and early detection. However, genetic testing itself does not i...

    Authors: Deborah Cragun, Jason Beckstead, Meagan Farmer, Gillian Hooker, Marleah Dean, Ellen Matloff, Sonya Reid, Ann Tezak, Anne Weidner, Jennifer G. Whisenant and Tuya Pal
    Citation: BMC Cancer 2021 21:1099
  39. This study aimed to develop a reliable immune signature based on B-cell proportion to predict the prognosis and benefit of immunotherapy in LUAD.

    Authors: Yi Zhang, Xuewen Yin, Qi Wang, Xuming Song, Wenjie Xia, Qixing Mao, Bing Chen, Yingkuan Liang, Te Zhang, Lin Xu, Feng Jiang, Xinyu Xu and Gaochao Dong
    Citation: BMC Cancer 2021 21:1098
  40. Pancreatic cancer has highly aggressive features, such as local recurrence that leads to significantly high morbidity and mortality and recurrence after successful tumour resection. Intraoperative radiation th...

    Authors: Yun Sun Lee, Hyung Sun Kim, Yeona Cho, Ik Jae Lee, Hyo Jung Kim, Da Eun Lee, Hyeon Woong Kang and Joon Seong Park
    Citation: BMC Cancer 2021 21:1097
  41. Lung adenocarcinoma (LUAD) is the most prevalent non-small cell lung cancer (NSCLC). Patients with LUAD have a poor 5-year survival rate. The use of immune checkpoint inhibitors (ICIs) for the treatment of LUA...

    Authors: Weishuang Ma, Jiaming Liang, Junjian Mo, Siyuan Zhang, Ningdong Hu, Dongbo Tian and Zisheng Chen
    Citation: BMC Cancer 2021 21:1096

    The Correction to this article has been published in BMC Cancer 2021 21:1146

  42. We aimed to analyze the clinicopathological features and outcomes of patients with gastric-type of HPV-independent endocervical adenocarcinoma (GAS HPVI ECA), and compare them with non-GAS HPVI ECA cases.

    Authors: Lili Chen, Yizhen Niu, Xiaoyun Wan, Lina Yu, Xiaofei Zhang, Amanda Louise Strickland, Liya Dong, Feng Zhou and Weiguo Lu
    Citation: BMC Cancer 2021 21:1095
  43. To ensure safe delivery of oncologic care during the COVID-19 pandemic, telemedicine has been rapidly adopted. However, little data exist on the impact of telemedicine on quality and accessibility of oncologic...

    Authors: Vivek Nimgaonkar, Charu Aggarwal, Abigail T. Berman, Peter Gabriel, Lawrence N. Shulman, John Kucharczuk, Megan Roy, Joshua M. Bauml, Aditi P. Singh, Roger B. Cohen, Corey J. Langer and Melina E. Marmarelis
    Citation: BMC Cancer 2021 21:1094
  44. An underlying cause of solid tumor resistance to chemotherapy treatment is diminished tumor blood supply, which leads to a hypoxic microenvironment, dependence on anaerobic energy metabolism, and impaired deli...

    Authors: Amy A. Kirkham, Karen King, Anil A. Joy, André B. Pelletier, John R. Mackey, Kelvin Young, Xiaofu Zhu, Judith Meza-Junco, Sanraj K. Basi, Julie Price Hiller, Tina Brkin, Bonnie Michalowski, Edith Pituskin, D. Ian Paterson, Kerry S. Courneya, Richard B. Thompson…
    Citation: BMC Cancer 2021 21:1093
  45. In oncology, liquid biopsy is of major relevance from theranostic point of view. The searching for mutations in circulating tumor DNA (ctDNA) in case of colorectal cancers (CRCs) allows the optimization of pat...

    Authors: Alexis Overs, Mylène Flammang, Eric Hervouet, Laurent Bermont, Jean-Luc Pretet, Borg Christophe and Zohair Selmani
    Citation: BMC Cancer 2021 21:1092
  46. Current opinions on whether surgical patients with cervical cancer should undergo para-aortic lymphadenectomy at the same time are inconsistent. The present study examined differences in survival outcomes with...

    Authors: Chunlin Chen, Hui Duan, Wenling Zhang, Hongwei Zhao, Li Wang, Shan Kang, Lihong Lin, Weidong Zhao, Yan Ni, Donglin Li, Jiaming Chen, Huijian Fan, Xiaolin Chen, Xiaonong Bin, Jinghe Lang and Ping Liu
    Citation: BMC Cancer 2021 21:1091
  47. Genetic alterations are common in non-small cell lung cancer (NSCLC), and DNA mutations and translocations are targets for therapy. Copy number aberrations occur frequently in NSCLC tumors and may influence ge...

    Authors: Maria Moksnes Bjaanæs, Gro Nilsen, Ann Rita Halvorsen, Hege G. Russnes, Steinar Solberg, Lars Jørgensen, Odd Terje Brustugun, Ole Christian Lingjærde and Åslaug Helland
    Citation: BMC Cancer 2021 21:1089
  48. The aminoisoquinoline FX-9 shows pro-apoptotic and antimitotic effects against lymphoblastic leukemia cells and prostate adenocarcinoma cells. In contrast, decreased cytotoxic effects against non-neoplastic bl...

    Authors: F. Weiner, J. T. Schille, D. Koczan, X.-F. Wu, M. Beller, C. Junghanss, M. Hewicker-Trautwein, H. Murua Escobar and I. Nolte
    Citation: BMC Cancer 2021 21:1088
  49. Cancer remains one of the leading causes of death worldwide, despite the possibilities to detect early onset of the most common cancer types. The search for the optimal therapy is complicated by the cancer div...

    Authors: Zane Simsone, Tālivaldis Freivalds, Dina Bēma, Indra Miķelsone, Liene Patetko, Juris Bērziņš, Līga Harju and Indulis Buiķis
    Citation: BMC Cancer 2021 21:1087

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