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  1. The prognostic impact of EGFR mutation as major targetable somatic gene variant on lung adenocarcinoma is controversial. KRAS is another major somatic variant in lung adenocarcinoma, and a therapeutic agent for K...

    Authors: Masaoki Ito, Yoshihiro Miyata, Kei Kushitani, Daisuke Ueda, Yukio Takeshima and Morihito Okada
    Citation: BMC Cancer 2023 23:248
    Content type: Research Published on:

  2. The purpose of this study was to explore the short-term efficacy and safety of neoadjuvant chemotherapy combined with arterial chemoembolization for locally advanced gastric cancer (LAGC).

    Authors: Jianguo Yang, Juncai Li, Qican Deng, Zhenzhou Chen, Kuan He, Yajun Chen and Zhongxue Fu
    Citation: BMC Cancer 2023 23:246
    Content type: Research Published on:

  3. Liver cancer is the third most deadly malignant tumor in the world with poor prognosis and lacks early diagnostic markers. It is urgent need to explore new biomarkers and prognostic factors. The oxysterol-bind...

    Authors: Kunpeng Tian, Yongling Ying, Jingjing Huang, Hao Wu, Chengyue Wei, Liang Li, Longjun Chen and Lichuan Wu
    Citation: BMC Cancer 2023 23:244
    Content type: Research Published on:

  4. Endometrial carcinoma (EC) is one of the most common gynecological malignancies in China and globally, accounting for the fourth-prevalent cancer in women. Although numerous studies have confirmed prognostic v...

    Authors: Zihui Yang, Xi Yang, Xinyu Liu, Ke Ma, Yi-Ting Meng, Hong-Fang Yin, Jia Wen, Jiang-Hui Yang, Zeng Zhen, Zong-Hao Feng and Qin-Ping Liao
    Citation: BMC Cancer 2023 23:243
    Content type: Research Published on:

  5. Chaperonin-containing tailless complex polypeptide 1 (TCP1) subunit 3 (CCT3) has tumor-promoting effects in lung adenocarcinoma (LUAD). This study aims to investigate the molecular mechanisms of CCT3 in LUAD o...

    Authors: Junfeng Huang, Bingqi Hu, Ying Yang, Huanhuan Liu, Xingyu Fan, Jing Zhou and Liwen Chen
    Citation: BMC Cancer 2023 23:241
    Content type: Research Published on:

  6. Breast cancer has become the most common malignant tumour worldwide. Distant metastasis is one of the leading causes of breast cancer-related death. To verify the performance of clinicomics-guided distant meta...

    Authors: Chao Zhang, Lisha Qi, Jun Cai, Haixiao Wu, Yao Xu, Yile Lin, Zhijun Li, Vladimir P. Chekhonin, Karl Peltzer, Manqing Cao, Zhuming Yin, Xin Wang and Wenjuan Ma
    Citation: BMC Cancer 2023 23:239
    Content type: Research Published on:

  7. Preclinical studies suggest that glucocorticoids (GCs) promote the proliferation and development of colorectal cancer. Because GCs are broadly prescribed for treatment-related adverse events in patients with l...

    Authors: Xiaoxue Huang, Zhiyuan Zheng, Bangwei Zeng, Han Xiao, Hao Zheng, Zhuangbin Lin, Jianyuan Song, Anchuan Li, Pan Chi, Yinghong Yang, Benhua Xu and Rong Zheng
    Citation: BMC Cancer 2023 23:238
    Content type: Research Published on:

  10. At present, there are a variety of antiviral drugs for HBV in clinical practice, but there is no standard scheme for transcatheter arterial chemoembolization(TACE) combined with antiviral drugs. The aim of thi...

    Authors: Haohao Lu, Chuansheng Zheng, Bin Xiong and Xiangwen Xia
    Citation: BMC Cancer 2023 23:235
    Content type: Research Published on:

  11. The T790M mutation is the major resistance mechanism to first- and second-generation TKIs in EGFR-mutant NSCLC. This study aimed to investigate the utility of droplet digital PCR (ddPCR) for detection of T790M...

    Authors: Chun-Ta Huang, Chih-An Lin, Te-Jen Su, Ching-Yao Yang, Tzu-Hsiu Tsai, Chia-Lin Hsu, Wei-Yu Liao, Kuan-Yu Chen, Chao-Chi Ho and Chong-Jen Yu
    Citation: BMC Cancer 2023 23:234
    Content type: Research Published on:

  12. Late detection of hepatocellular carcinoma (HCC) results in an overall 5-year survival rate of less than 16%. Liquid biopsy (LB) assays based on detecting circulating tumor DNA (ctDNA) might provide an opportu...

    Authors: Van-Chu Nguyen, Trong Hieu Nguyen, Thanh Hai Phan, Thanh-Huong Thi Tran, Thu Thuy Thi Pham, Tan Dat Ho, Hue Hanh Thi Nguyen, Minh-Long Duong, Cao Minh Nguyen, Que-Tran Bui Nguyen, Hoai-Phuong Thi Bach, Van-Vu Kim, The-Anh Pham, Bao Toan Nguyen, Thanh Nhan Vo Nguyen, Le Anh Khoa Huynh…
    Citation: BMC Cancer 2023 23:233
    Content type: Research Published on:

  13. Germ cell tumors are relatively common in young men. They derive from a non-invasive precursor, called germ cell neoplasia in situ, but the exact pathogenesis is still unknown. Thus, further understanding prov...

    Authors: Birte Schulz, Valérie Schumacher, Anaclet Ngezahayo, Daniela Maier-Begandt, Nadine Schadzek, Jochen Wilhelm, Wolfgang Weidner, Adrian Pilatz, Daniela Fietz, Sabine Kliesch, Nadine Schnepel, Nina Hambruch, Kristina Rode, Marion Langeheine and Ralph Brehm
    Citation: BMC Cancer 2023 23:232
    Content type: Research Published on:

  14. Dose reduction of tyrosine kinase inhibitors (TKI) in patients with chronic myeloid leukaemia (CML) with an optimal response to TKIs may support cost-effective medication use by maintaining therapeutic effecti...

    Authors: Melissa F Djodikromo, Rosella PMG Hermens, Bart JF van den Bemt, Yolba Smit, Tim M Govers, Charlotte L Bekker and Nicole MA Blijlevens
    Citation: BMC Cancer 2023 23:231
    Content type: Study Protocol Published on:

  18. An early diagnosis of pancreatic cancer (PC) is extremely difficult because of the lack of sensitive liquid biopsy methods and effective biomarkers. We attempted to evaluate whether circulating inflammatory ma...

    Authors: Yuanlong Gu, Qianjin Hua, Zhipeng Li, Xingli Zhang, Changjie Lou, Yangfen Zhang, Wei Wang, Peiyuan Cai and Juan Zhao
    Citation: BMC Cancer 2023 23:227
    Content type: Research Published on:

  21. A previous meta-analysis examining the relationship between statin use and breast cancer reported that the inhibitory effect of statins on breast cancer may be more pronounced in early-stage cases. In this stu...

    Authors: Koji Takada, Shinichiro Kashiwagi, Nozomi Iimori, Rika Kouhashi, Akimichi Yabumoto, Wataru Goto, Yuka Asano, Yukie Tauchi, Tamami Morisaki, Kana Ogisawa, Masatsune Shibutani, Hiroaki Tanaka and Kiyoshi Maeda
    Citation: BMC Cancer 2023 23:224
    Content type: Research article Published on:

  22. Radiotherapy is one of the cornerstones of the treatment of Head and Neck Squamous Cell Carcinomas (HNSCC). However, radioresistance is associated with a high risk of recurrence. To propose strategies (such as co...

    Authors: Marion Perréard, Romane Florent, Jordane Divoux, Jean-Michel Grellard, Justine Lequesne, Mélanie Briand, Bénédicte Clarisse, Nathalie Rousseau, Esther Lebreton, Brice Dubois, Valentin Harter, Audrey Lasne-Cardon, Julien Drouet, Alisson Johnson, Anne-Laure Le Page, Céline Bazille…
    Citation: BMC Cancer 2023 23:223
    Content type: Study Protocol Published on:

  23. Our previous studies have confirmed that miR-154-5p can regulate pRb expression, and thus, play a tumor suppressor role in HPV16 E7-induced cervical cancer. However, its upstream molecules have not been elucid...

    Authors: Honglei Zhang, Xiuting Wang, Yaqin Li, Ying Bai, Qi Li, Shuling Wang, Yimiao Wei, Jiarong Li, Songquan Wen and Weihong Zhao
    Citation: BMC Cancer 2023 23:222
    Content type: Research Published on:

  24. Large-scale genomic alterations, especially CD274/PD-L1 gene amplification, have great impact on anti-PD-1 efficacy on cancers such as Hodgkin’s lymphoma. However, the prevalence of PD-L1 genetic alterations i...

    Authors: Lin Yang, Shousheng Liu, Wenzhuo He, Zhenchong Xiong and Liangping Xia
    Citation: BMC Cancer 2023 23:221
    Content type: Research Published on:

  25. CD40, a TNF receptor family member, is expressed by a variety of immune cells and is involved in the activation of both adaptive and innate immune responses. Here, we used quantitative immunofluorescence (QIF)...

    Authors: Katherine M. Bates, Ioannis Vathiotis, Tyler MacNeil, Fahad Shabbir Ahmed, Thazin Nwe Aung, Yuliya Katlinskaya, Sabyasachi Bhattacharya, Amanda Psyrri, Steven Yea, Amanda Parkes, Nooshin Hashemi Sadraei, Siddhartha Roychoudhury, David L. Rimm and Niki Gavrielatou
    Citation: BMC Cancer 2023 23:220
    Content type: Research Published on:

  26. Soft tissue sarcomas (STS) are a rare type of malignancy comprising a variety of histological diagnoses. Chemotherapy constitutes the standard treatment for advanced STS. Doxorubicin-based regimens, which incl...

    Authors: Makoto Endo, Tomoko Kataoka, Toshifumi Fujiwara, Satoshi Tsukushi, Masanobu Takahashi, Eisuke Kobayashi, Yoko Yamada, Takaaki Tanaka, Yutaka Nezu, Hiroaki Hiraga, Junji Wasa, Akihito Nagano, Kenji Nakano, Robert Nakayama, Tetsuya Hamada, Masanori Kawano…
    Citation: BMC Cancer 2023 23:219
    Content type: Study Protocol Published on:

  27. Adenocarcinoma of the esophagogastric junction (AEG) is increasing worldwide. Lymph node metastasis is an important clinical issue in AEG patients. This study investigated the usefulness of a positive lymph no...

    Authors: Hajime Kamiya, Shuhei Komatsu, Keiji Nishibeppu, Takuma Ohashi, Hirotaka Konishi, Atsushi Shiozaki, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto and Eigo Otsuji
    Citation: BMC Cancer 2023 23:218
    Content type: Research Published on:

  28. Primary double KIT/PDGFRA mutations are very rare in gastrointestinal stromal tumours (GISTs) but have not been comprehensively studied to date. In the present study, we investigated the clinicopathologic and ...

    Authors: Jiaqi Yan, Xin He, Chaoyong Shen, Yan Zou, Huijiao Chen and Yuan Tang
    Citation: BMC Cancer 2023 23:217
    Content type: Research Published on:

  29. A subset of meningiomas progress in histopathological grade but drivers of progression are poorly understood. We aimed to identify somatic mutations and copy number alterations (CNAs) associated with grade pro...

    Authors: Sarah A Cain, Bernard Pope, Stefano Mangiola, Theo Mantamadiotis and Katharine J Drummond
    Citation: BMC Cancer 2023 23:216
    Content type: Research Published on:

  30. The CyberKnife system features a robotically-positioned linear accelerator to deliver real-time image-guided stereotactic ablative body radiotherapy (SABR). It achieves steep dose gradients using irradiation f...

    Authors: Kazuhiko Hayashi, Osamu Suzuki, Hiroya Shiomi, Hitoshi Ono, Akira Setoguchi, Masataka Nakai, Erina Nakanishi, Shotaro Tatekawa, Naoko Ose, Takero Hirata, Keisuke Tamari, Yuji Seo, Soichiro Funaki, Fumiaki Isohashi, Shinichi Shimizu, Yasushi Shintani…
    Citation: BMC Cancer 2023 23:215
    Content type: Research Published on:

  31. Despite the widespread availability of medication choices for metastatic castration-resistant prostate cancer (mCRPC), biomarkers to predict the efficacy of each mCRPC treatment have not yet been established. ...

    Authors: Takashi Kawahara, Yusuke Saigusa, Shuko Yoneyama, Masashi Kato, Ippei Kojima, Hiroshi Yamada, Osamu Kamihira, Kenichi Tabata, Hideyasu Tsumura, Masatsugu Iwamura, Kazuhide Makiyama, Hiroji Uemura and Yasuhide Miyoshi
    Citation: BMC Cancer 2023 23:214
    Content type: Research Published on:

  32. In a country with a high prevalence of cigarette smoking, betel chewing, and alcohol drinking, cancers of the oral cavity, nasopharynx, and larynx were the fourth, twelfth and seventeenth leading causes of can...

    Authors: Yu-Shiun Tsai, Yong-Chen Chen, Tzu-I Chen, Yu-Kwang Lee, Chun-Ju Chiang, San-Lin You, Wan-Lun Hsu and Li-Jen Liao
    Citation: BMC Cancer 2023 23:213
    Content type: Research Published on:

  33. Literature review have shown that sarcopenia substantially alters the postoperative outcomes after liver resection for malignant tumors. However, these retrospective studies do not distinguish cirrhotic and no...

    Authors: Jinhuan Yang, Daojie Wang, Lei Ma, Xuewen An, Zijing Hu, Huili Zhu, Wanqian Zhang, Kaiwen Chen, Jun Ma, Yan Yang, Lijun Wu, Gang Chen and Yi Wang
    Citation: BMC Cancer 2023 23:212
    Content type: Research Published on:

  34. The prognosis of patients with previously treated advanced gastric or gastroesophageal junction (GEJ) cancer remains poor. Given the robust development of immunotherapy and targeted therapy during the last dec...

    Authors: Le Zhang, Weixue Wang, Shaohua Ge, Hongli Li, Ming Bai, Jingjing Duan, Yuchong Yang, Tao Ning, Rui Liu, Xia Wang, Zhi Ji, Feixue Wang, Haiyang Zhang, Yi Ba and Ting Deng
    Citation: BMC Cancer 2023 23:211
    Content type: Research Published on:

  35. The clinical application of anthracycline chemotherapy is hindered due to the cumulative dose-dependent cardiotoxicity followed by the oxidative stress initiated during the mechanism of action of anthracycline...

    Authors: Jayasinghe Arachchige Nirosha Sandamali, Ruwani Punyakanthi Hewawasam, Madappuli Arachchige Chaminda Sri Sampath Fernando and Kamani Ayoma Perera Wijewardana Jayatilaka
    Citation: BMC Cancer 2023 23:210
    Content type: Research Published on:

  36. Studies from Asia indicate that normothermic intraperitoneal chemotherapy (NIPEC) may confer survival benefit in patients with gastric peritoneal carcinomatosis (PC). However, data regarding this approach is l...

    Authors: Maheswari Senthil and Farshid Dayyani
    Citation: BMC Cancer 2023 23:209
    Content type: Research Published on:

  37. Lipid metabolism disorders may be involved in the occurrence and development of breast cancer. This study aimed to investigate the serum lipid changes during neoadjuvant chemotherapy for breast cancer and the ...

    Authors: Youzhao Ma, Minhao Lv, Peng Yuan, Xiuchun Chen and Zhenzhen Liu
    Citation: BMC Cancer 2023 23:208
    Content type: Research Published on:

  38. Anlotinib is a multi-targeted receptor tyrosine kinase inhibitor (TKI) which has exhibited encouraging clinical activity in advanced non-small cell lung cancer (NSCLC) and soft tissue sarcoma. Raltitrexed is w...

    Authors: Hongchao Zhen, Jizheng Tian, Guangxin Li, Pengfei Zhao, Ying Zhang, Juanjuan Che and Bangwei Cao
    Citation: BMC Cancer 2023 23:207
    Content type: Research Published on:

  39. Central nervous system (CNS) metastases including brain metastases (BM) and leptomeningeal metastases (LM) are frequent in epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), and a...

    Authors: Ziyi Xu, Xuezhi Hao, Qi Wang, Ke Yang, Junling Li and Puyuan Xing
    Citation: BMC Cancer 2023 23:206
    Content type: Research Published on:

  40. In this study we aimed to evaluate the efficacy and safety of the PD-L1 inhibitor durvalumab across various mismatch repair deficient (dMMR) or microsatellite instability-high (MSI-H) tumours in the Drug Redis...

    Authors: Birgit S. Geurts, Thomas W. Battaglia, J. Maxime van Berge Henegouwen, Laurien J. Zeverijn, Gijs F. de Wit, Louisa R. Hoes, Hanneke van der Wijngaart, Vincent van der Noort, Paul Roepman, Wendy W. J. de Leng, Anne M. L. Jansen, Frans L. Opdam, Maja J. A. de Jonge, Geert A. Cirkel, Mariette Labots, Ann Hoeben…
    Citation: BMC Cancer 2023 23:205
    Content type: Research Published on:

  41. Laparoscopic colorectal surgery has been proved to have similar oncological outcomes with open surgery. Due to the lack of tactile perception, surgeons may have misjudgments in laparoscopic colorectal surgery....

    Authors: Ke-hui Zhang, Jing-ze Li, Hai-bin Zhang, Ren-hao Hu, Xi-mao Cui, Tao Du, Liang Zheng, Shun Zhang, Chun Song, Mei-dong Xu and Xiao-hua Jiang
    Citation: BMC Cancer 2023 23:204
    Content type: Study protocol Published on:

  42. With the application of immune checkpoint inhibitors (ICIs) in cancer treatment, more and more attention has been paid to checkpoint inhibitor-related pneumonitis (CIP), which requires a better understanding o...

    Authors: Li Pang, Mei Xie, Xidong Ma, Aiben Huang, Jialin Song, Jie Yao, Hui Deng, Duchao Zhang, Xuelei Zang, Fangping Ren, Jie Gao, Chongchong Wu, Yuanyong Wang, Xin Zhang, Xinyu Bao, Lei Pan…
    Citation: BMC Cancer 2023 23:203
    Content type: Research Published on:

  43. Relapse is a frequent occurrence in autologous hematopoietic stem cell transplantation (AHSCT), and early relapse after AHSCT results in poor survival and low quality of life. Predictive marker determination f...

    Authors: Mohammad Rafiee, Fatemeh Amiri, Mohammad Hossein Mohammadi and Abbas Hajifathali
    Citation: BMC Cancer 2023 23:202
    Content type: Research Published on:

  44. Using texture features derived from contrast-enhanced computed tomography (CT) combined with general imaging features as well as clinical information to predict treatment response and survival in patients with...

    Authors: He An, Inderjeet Bhatia, Fei Cao, Zilin Huang and Chuanmiao Xie
    Citation: BMC Cancer 2023 23:201
    Content type: Research Published on:

  45. Patients with breast cancer undergo various treatments according to their tumor subtype and cancer stages within 1 year after being diagnosed. Each treatment may cause treatment-related symptoms that have nega...

    Authors: Jiin Ryu, Eun-Young Lee, Jihee Min, Sujin Yeon, Ji-Won Lee, Sang Hui Chu, Hyangkyu Lee, Seung Il Kim, Jee Ye Kim, Seho Park and Justin Y. Jeon
    Citation: BMC Cancer 2023 23:200
    Content type: Study Protocol Published on:

  46. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease harboring significant microenvironment heterogeneity, especially for the macrophages. Tumor-associated macrophages (TAMs) orchestrate PDAC mal...

    Authors: Kaidi Yang, Tongxin Yang, Jian Yu, Fang Li and Xiang Zhao
    Citation: BMC Cancer 2023 23:199
    Content type: Research Published on:

  47. Non-small cell cancer (NSCLC) patients with concomitant epidermal growth factor receptor (EGFR) and TP53 mutations have a poor prognosis with the treatment of tyrosine kinase inhibitors (TKIs), and may benefit...

    Authors: Haiyan Sun, Peng Ren, Yongzi Chen, Lan Lan, Zhuchen Yan, Yinli Yang, Bin Wang, Cong Wang, Yanwei Li, Ling Li, Yu Zhang, Yanyang Li, Zuolin Wang, Zhanyu Pan and Zhansheng Jiang
    Citation: BMC Cancer 2023 23:198
    Content type: Research Published on:

  48. Esophageal squamous cell carcinoma (ESCC) metastasizes in an unpredictable fashion to adjacent lymph nodes, including those along the recurrent laryngeal nerves (RLNs). This study is to apply machine learning ...

    Authors: Yiliang Zhang, Longfu Zhang, Bin Li, Ting Ye, Yang Zhang, Yongfu Yu, Yuan Ma, Yihua Sun, Jiaqing Xiang, Yike Li and Haiquan Chen
    Citation: BMC Cancer 2023 23:197
    Content type: Research Published on:

  49. Wilms tumor (WT) is the second most common solid tumor in Africa with both low overall survival (OS) and event-free survival (EFS) rates. However, no known factors are predicting this poor overall survival.

    Authors: Eddymond Ekuk, Charles Newton Odongo, Leevan Tibaijuka, Felix Oyania, Walufu Ivan Egesa, Felix Bongomin, Raymond Atwiine, Moses Acan and Martin Situma
    Citation: BMC Cancer 2023 23:196
    Content type: Research Published on:

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