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  1. Although the incidence of late-onset colorectal cancer (LOCRC) has decreased, the incidence of early-onset colorectal cancer (EOCRC) is still rising dramatically. Heterogeneity in the genomic, biological, and ...

    Authors: Meijuan Xiang, Yuan Gao, Yue Zhou, Muqing Wang and Xueqing Yao
    Citation: BMC Cancer 2023 23:595
    Content type: Research Published on:

  2. Chemoradiotherapy (CRT) remains the standard treatment for locally advanced rectal cancer (LARC). This phase 2 clinical trial was designed to evaluate the efficacy and safety of neoadjuvant triplet chemotherap...

    Authors: Wen Zhang, Haitao Zhou, Jun Jiang, Yuelu Zhu, Shuangmei Zou, Liming Jiang, Yuan Tang, Jianwei Liang, Yongkun Sun, Zhichao Jiang, Wang Qu, Ying Li and Aiping Zhou
    Citation: BMC Cancer 2023 23:592
    Content type: Research Published on:

  3. Cancer-associated fibroblasts (CAFs) have significant tumor regulatory functions, and CAFs-derived exosomes (CAFs-Exo) released from CAFs play an important role in the progression of oral squamous cell carcino...

    Authors: Wei-Zhou Wang, Xue Cao, Li Bian, Yue Gao, Ming Yu, Yi-Ting Li, Jian-Guo Xu, Yang-Hao Wang, He-Feng Yang, Ding-Yun You and Yong-Wen He
    Citation: BMC Cancer 2023 23:591
    Content type: Research Published on:

  4. Women with inherited mutations in the BRCA1 or BRCA2 genes have increased lifetime risks for developing breast and/or ovarian cancer and may develop these cancers around the age of 30 years. Therefore, prevention...

    Authors: Lára R. Hallsson, Gaby Sroczynski, Jutta Engel and Uwe Siebert
    Citation: BMC Cancer 2023 23:590
    Content type: Research Published on:

  5. Solute carrier family 25 member 32 (SLC25A32) is an important member of SLC25A family and plays a role in folate transport metabolism. However, the mechanism and function of SLC25A32 in the progression of huma...

    Authors: Zhiwei Xue, Jiwei Wang, Zide Wang, Junzhi Liu, Jiangli Zhao, Xuchen Liu, Yan Zhang, Guowei Liu, Zhimin Zhao, Wenjie Li, Qing Zhang, Xingang Li, Bin Huang and Xinyu Wang
    Citation: BMC Cancer 2023 23:589
    Content type: Research Published on:

  8. Histone acetyltransferases (HATs) of the MYST family are associated with a variety of human cancers. However, the relationship between MYST HATs and their clinical significance in kidney renal clear cell carci...

    Authors: Fan Liang, Xiangke Li, Xiaoman Shen, Runlei Yang and Chuan Chen
    Citation: BMC Cancer 2023 23:586
    Content type: Research Published on:

  9. Although polypharmacy has been described among cancer patients, very few studies have focused on those with lung cancer. We aimed to assess whether polypharmacy and comorbidity have an impact on systemic paren...

    Authors: Hélène Pluchart, Sébastien Bailly, Sébastien Chanoine, Denis Moro-Sibilot, Pierrick Bedouch and Anne-Claire Toffart
    Citation: BMC Cancer 2023 23:585
    Content type: Research Published on:

  11. Breast cancer is a malignant tumour that seriously threatens women’s life and health and exhibits high inter-individual heterogeneity, emphasising the need for more in-depth research on its pathogenesis. While...

    Authors: Qinghua Huang, Jianlan Mo, Huawei Yang, Yinan Ji, Rong Huang, Yan Liu and You Pan
    Citation: BMC Cancer 2023 23:583
    Content type: Research Published on:

  13. Treatment decisions in prostate cancer (PCa) rely on disease stratification between localised and metastatic stages, but current imaging staging technologies are not sensitive to micro-metastatic disease. Circ...

    Authors: Tarek Al-Hammouri, Ricardo Almeida-Magana, Rachel Lawrence, Tom Duffy, Laura White, Edwina Burke, Sakunthala Kudahetti, Justin Collins, Prabhakar Rajan, Daniel Berney, Rhian Gabe, Greg Shaw and Yong-Jie Lu
    Citation: BMC Cancer 2023 23:581
    Content type: Study Protocol Published on:

  14. Weight changes after gastrectomy affect not only quality of life but also prognosis and survival. However, it remains challenging to predict the weight changes of individual patients. Using clinicopathological...

    Authors: Chul-Hyo Jeon, Ki Bum Park, Sojung Kim, Ho Seok Seo, Kyo Young Song and Han Hong Lee
    Citation: BMC Cancer 2023 23:580
    Content type: Research Published on:

  15. Cartilaginous neoplasms can be challenging to grade; there is a need to create an evidence-based rubric for grading. The goal of this study was to identify histopathologic features of chondrosarcoma that were ...

    Authors: Alexander L. Lazarides, Bijan Abar, Bruce Leckey, John T. Martin, Evelyna G. Kliassov, Brian E. Brigman, William C. Eward, Diana M. Cardona and Julia D. Visgauss
    Citation: BMC Cancer 2023 23:579
    Content type: Research Published on:

  16. This study aimed to investigate the clinical utility of diverse aneuploid circulating tumor cell (CTC) subtypes and particularly CTC-associated white blood cell (CTC-WBC) clusters in predicting treatment respo...

    Authors: Ying Wang, Yanxia Liu, Zhiyun Zhang, Baohua Lu, Yuan Gao, Li Tong, Mingming Hu, Peter Ping Lin, Baolan Li and Tongmei Zhang
    Citation: BMC Cancer 2023 23:578
    Content type: Research Published on:

  17. Despite their heterogeneity, the current standard preoperative radiotherapy regimen for localized high-grade soft tissue sarcoma (STS) follows a one fits all approach for all STS subtypes. Sarcoma patient-deri...

    Authors: Siyer Roohani, Jürgen Loskutov, Jens Heufelder, Felix Ehret, Lena Wedeken, Manuela Regenbrecht, Rica Sauer, Daniel Zips, Andrea Denker, Antonia M. Joussen, Christian R. A. Regenbrecht and David Kaul
    Citation: BMC Cancer 2023 23:577
    Content type: Research Published on:

  18. To the best of our knowledge, no previous studies have explored the relationship between visceral obesity and malnutrition. Therefore, this study has aimed to investigate the association between them in patien...

    Authors: Chong-Jun Zhou, Yi Lin, Jie-Yu Liu, Zhong-Lin Wang, Xi-Yi Chen and Chen-Guo Zheng
    Citation: BMC Cancer 2023 23:576
    Content type: Research Published on:

  19. Prostate cancer (PCa) is one of the most prevalent cancers worldwide. The clinical manifestations and molecular characteristics of PCa are highly variable. Aggressive types require radical treatment, whereas i...

    Authors: Carolin Schimmelpfennig, Michael Rade, Susanne Füssel, Dennis Löffler, Conny Blumert, Catharina Bertram, Angelika Borkowetz, Dominik J. Otto, Sven-Holger Puppel, Pia Hönscheid, Ulrich Sommer, Gustavo B. Baretton, Ulrike Köhl, Manfred Wirth, Christian Thomas, Friedemann Horn…
    Citation: BMC Cancer 2023 23:575
    Content type: Research Published on:

  20. This study aimed to evaluate the clinical significance of a novel systemic immune-inflammation score (SIIS) to predict oncological outcomes in upper urinary tract urothelial carcinoma(UTUC) after radical nephr...

    Authors: Jianyong Liu, Pengjie Wu, Shicong Lai, Jianye Wang, Huimin Hou and Yaoguang Zhang
    Citation: BMC Cancer 2023 23:574
    Content type: Research Published on:

  21. The ubiquity-proteasome system is an indispensable mechanism for regulating intracellular protein degradation, thereby affecting human antigen processing, signal transduction, and cell cycle regulation. We use...

    Authors: Xiao Li, Xinru Li, Yuexin Hu, Ouxuan Liu, Yuxuan Wang, Siting Li, Qing Yang and Bei Lin
    Citation: BMC Cancer 2023 23:573
    Content type: Research Published on:

  22. Given the role of systematic inflammation in cancer progression, lymphocyte-monocyte ratio (LMR) from peripheral blood has been suggested as a biomarker to assess the extent of inflammation in several solid ma...

    Authors: Brian Yu, Sung Jun Ma, Michael Khan, Jasmin Gill, Austin Iovoli, Fatemeh Fekrmandi, Mark K. Farrugia, Kimberly Wooten, Vishal Gupta, Ryan McSpadden, Moni A. Kuriakose, Michael R. Markiewicz, Ayham Al-Afif, Wesley L. Hicks Jr., Mukund Seshadri, Andrew D. Ray…
    Citation: BMC Cancer 2023 23:572
    Content type: Research Published on:

  23. Robotic nipple-sparing mastectomy (RNSM) has emerged as a new treatment option for breast cancer and risk-reducing mastectomy (RRM) for women who have a high risk of pathogenic variants. Even though several st...

    Authors: Jai Min Ryu, Jeea Lee, Jeeyeon Lee, BeomSeok Ko, Joo Heung Kim, Hyukjai Shin and Hyung Seok Park
    Citation: BMC Cancer 2023 23:571
    Content type: Study protocol Published on:

  24. Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of taxane treatment and can significantly affect patient quality of life. Currently, there are no effective treatments to alleviate ...

    Authors: Young-Joon Kang, Chang Ik Yoon, Yun-Jung Yang, Jong Min Baek, Yong-Seok Kim, Ye Won Jeon, Jiyoung Rhu, Jae Pak Yi, Dooreh Kim and Se Jeong Oh
    Citation: BMC Cancer 2023 23:570
    Content type: Study Protocol Published on:

  25. The expression of programmed death-ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TILs), E-cadherin, and vimentin in lung cancer tumor microenvironment is known to impact patient survival or response to the...

    Authors: Yu-Ping Chang, Gong-Kai Huang, Yung-Che Chen, Kuo-Tung Huang, Yu-Mu Chen, Chiung-Yu Lin, Chao-Cheng Huang, Meng-Chih Lin and Chin-Chou Wang
    Citation: BMC Cancer 2023 23:569
    Content type: Research Published on:

  26. To investigate the survival outcomes of metastatic castration-resistant prostate cancer (mCRPC) patients receiving first-line novel androgen receptor axis-targeted therapies (ARATs) and prognostic factors for ...

    Authors: Chi-Shin Tseng, Jui-Han Yang, Shi-Wei Huang, Yu-Jen Wang, Chung-Hsin Chen, Yeong-Shiau Pu, Jason Chia-Hsien Cheng and Chao-Yuan Huang
    Citation: BMC Cancer 2023 23:568
    Content type: Research Published on:

  27. Taiwan’s National Health Insurance has covered targeted therapy, namely cetuximab, for locally advanced head and neck cancers (LAHNC) since July 2009. This study examines treatment trends and survival effects ...

    Authors: Szu-Han Hu, Ming-Yii Huang, Chung-Yu Chen and Hui-Min Hsieh
    Citation: BMC Cancer 2023 23:567
    Content type: Research Published on:

  28. Epstein Barr virus (EBV)-associated endemic Burkitt’s Lymphoma pediatric cancer is associated with morbidity and mortality among children resident in holoendemic Plasmodium falciparum regions in western Kenya. P....

    Authors: Perez K. Olewe, Shehu Shagari Awandu, Elly O. Munde, Samuel B. Anyona, Evans Raballah, Asito S. Amolo, Sidney Ogola, Erick Ndenga, Clinton O. Onyango, Rosemary Rochford, Douglas J. Perkins and Collins Ouma
    Citation: BMC Cancer 2023 23:566
    Content type: Research Published on:

  29. This study was conducted to identify factors associated with the safety and effectiveness of pembrolizumab in Japanese patients with unresectable urothelial carcinoma and to confirm the real-world safety and e...

    Authors: Hiroyuki Nishiyama, Yu Tanaka, Masahiro Hamada, Masahiko Ozaki, Toshihiko Minegishi, Yuichiro Ito, Shinichiroh Maekawa and Nobuyuki Yamamoto
    Citation: BMC Cancer 2023 23:565
    Content type: Research Published on:

  30. Although antiviral treatments have been shown to affect the recurrence and long-term survival of patients with hepatocellular carcinoma (HCC) who have high viral loads, the effect of different responses to ant...

    Authors: Peng Wang, Xinhui Wang, Xiaoli Liu, Fengna Yan, Huiwen Yan, Dongdong Zhou, Lihua Yu, Xianbo Wang and Zhiyun Yang
    Citation: BMC Cancer 2023 23:564
    Content type: Research Published on:

  32. Associations of body shape with breast cancer risk, independent of body size, are unclear because waist and hip circumferences are correlated strongly positively with body mass index (BMI).

    Authors: Sofia Christakoudi, Konstantinos K. Tsilidis, Laure Dossus, Sabina Rinaldi, Elisabete Weiderpass, Christian S. Antoniussen, Christina C. Dahm, Anne Tjønneland, Lene Mellemkjær, Verena Katzke, Rudolf Kaaks, Matthias B. Schulze, Giovanna Masala, Sara Grioni, Salvatore Panico, Rosario Tumino…
    Citation: BMC Cancer 2023 23:562
    Content type: Research Published on:

  33. Paclitaxel in combination with ramucirumab is the standard of care second-line therapy in gastro-esophageal adenocarcinoma (GEA). As the number of taxane pretreated patients in the perioperative or first-line ...

    Authors: Sylvie Lorenzen, Alix Schwarz, Claudia Pauligk, Eray Goekkurt, Gertraud Stocker, Jorge Riera Knorrenschild, Gerald Illerhaus, Tobias Dechow, Markus Moehler, Jean-Charles Moulin, Daniel Pink, Michael Stahl, Marina Schaaf, Thorsten Oliver Goetze and Salah-Eddin Al-Batran
    Citation: BMC Cancer 2023 23:561
    Content type: Study protocol Published on:

  34. Cuproptosis is a regulated cell death form associated with tumor progression, clinical outcomes, and immune response. However, the role of cuproptosis in pancreatic adenocarcinoma (PAAD) remains unclear. This ...

    Authors: Xiaoling Zhang, Yuxin Zhou, Jiahe Hu, Xuefeng Yu, Haitao Xu, Zhichang Ba, Haoxin Zhang, Yanan Sun, Rongfang Wang, Xinlian Du, Ruishu Mou, Xuedong Li, Jiuxin Zhu and Rui Xie
    Citation: BMC Cancer 2023 23:560
    Content type: Research Published on:

  35. Peritoneal metastasis is one of the main causes of death in patients with gastric cancer (GC). Galectin-1 regulates various undesirable biological behaviors in GC and may be key in GC peritoneal metastasis.

    Authors: Xianhe Shen, Huilan Liu, Haihua Zhou, Zhiyi Cheng, Guiyuan Liu, Chuanjiang Huang, Rongrong Dou, Fuxing Liu and Xiaolan You
    Citation: BMC Cancer 2023 23:559
    Content type: Research Published on:

  36. Ovarian cancer is amongst one of the most commonly occurring cancers affecting women, and the leading cause of gynecologic related cancer death. Its poor prognosis and high mortality rates can be attributed to...

    Authors: Zahra Maleki, Mohebat Vali, Hossein-Ali Nikbakht, Soheil Hassanipour, Aida Kouhi, Saman Sedighi, Roya Farokhi and Haleh Ghaem
    Citation: BMC Cancer 2023 23:558
    Content type: Research Published on:

  37. Primary liver cancer is a malignant tumour of the digestive system, ranking second in cancer mortality in China. In different types of cancer, such as liver cancer, microRNAs (miRNAs) have been shown to be dys...

    Authors: Jing Yan, Bei Xie, Ye Tian, Wenqin An, Zhiheng Peng, Zhuan Liu, Jing Li and Linjing Li
    Citation: BMC Cancer 2023 23:557
    Content type: Research Published on:

  38. Immunotherapy has transformed cancer treatment patterns for advanced hepatocellular carcinoma (aHCC) in recent years. Therefore, the identification of predictive biomarkers has important clinical implications.

    Authors: Guhe Jia, Lupeng Qiu, Hongye Zheng, Boyu Qin, Zhuoya Sun, Yangyang Shao, Zizhong Yang, Jiakang Shao, Yuxin Zhou and Shunchang Jiao
    Citation: BMC Cancer 2023 23:556
    Content type: Research Published on:

  39. Metabolic syndrome (MetS) is associated with cancer risk; however, little is known regarding its relationship with the risk of cancer-related premature death and long-term sick leave (LTSL), which can lead to ...

    Authors: Dong Van Hoang, Yosuke Inoue, Ami Fukunaga, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Hiroko Okazaki, Makoto Yamamoto, Toshiaki Miyamoto, Naoki Gommori, Takeshi Kochi, Taiki Shirasaka, Masafumi Eguchi, Takayuki Ogasawara, Kenya Yamamoto, Maki Konishi…
    Citation: BMC Cancer 2023 23:555
    Content type: Research Published on:

  40. With more than 15,000 new cases /year in France and 2,000 deaths, cutaneous melanoma represents approximately 4% of incidental cancers and 1.2% of cancer related deaths. In locally advanced (stage III) or rese...

    Authors: Lionnel Geoffrois, Alexandre Harlé, Nassim Sahki, Aleksandra Sikanja, Florence Granel-Brocard, Alice Hervieu, Laurent Mortier, Géraldine Jeudy, Catherine Michel, Charlée Nardin, Cécile Huin-Schohn and Jean-Louis Merlin
    Citation: BMC Cancer 2023 23:554
    Content type: Study Protocol Published on:

  41. Neurofibromatosis type 1 (NF1), the most common tumor predisposition syndrome, occurs when NF1 gene variants result in loss of neurofibromin, a negative regulator of RAS activity. Plexiform neurofibromas (PN) are...

    Authors: Amy E. Armstrong, Allan J. Belzberg, John R. Crawford, Angela C. Hirbe and Zhihong J. Wang
    Citation: BMC Cancer 2023 23:553
    Content type: Review Published on:

  42. According to current evidence, the best treatment for fit patients with non-resectable pancreatic cancer (PC) is combination chemotherapy, whereas frail patients are recommended gemcitabine (Gem) monotherapy. ...

    Authors: Louise Skau Rasmussen, Stine B. Winther, Inna M. Chen, Britta Weber, Lise Ventzel, Gabor Liposits, Julia Sidenius Johansen, Sönke Detlefsen, Ida Egendal, Susy Shim, Signe Christensen, Per Pfeiffer and Morten Ladekarl
    Citation: BMC Cancer 2023 23:552
    Content type: Study Protocol Published on:

  43. Polymerase I and transcript release factor (PTRF) plays a role in the regulation of gene expression and the release of RNA transcripts during transcription, which have been associated with various human diseases....

    Authors: Si Sun, Changlin Yang, Kuanyu Wang, Ruoyu Huang, Ke-nan Zhang, Yanwei Liu, Zhi Cao, Zheng Zhao and Tao Jiang
    Citation: BMC Cancer 2023 23:551
    Content type: Research Published on:

  44. As an adult tumor with the most invasion and the highest mortality rate, the inherent heterogeneity of glioblastoma (GBM) is the main factor that causes treatment failure. Therefore, it is important to have a ...

    Authors: Lei Wei, Mika Pan, Qiulan Jiang, Beiquan Hu, Jianyi Zhao, Chun Zou, Liechun Chen, Chunhai Tang and Donghua Zou
    Citation: BMC Cancer 2023 23:550
    Content type: Research Published on:

  45. Immune-related genes (IRGs) have been confirmed to play an important role in tumorigenesis and tumor microenvironment formation in hepatocellular carcinoma (HCC). We investigated how IRGs regulates the HCC imm...

    Authors: Jialin Qu, Fenghao Sun, Yichen Hou, Haoran Qi, Xiaorong Sun and Ligang Xing
    Citation: BMC Cancer 2023 23:549
    Content type: Research Published on:

  46. In recent years, multiple coagulation and fibrinolysis (CF) indexes have been reported to be significantly related to the progression and prognosis of some cancers.

    Authors: Peng Yunpeng, Yin Lingdi, Zhu Xiaole, Huang Dongya, Hu Le, Lu Zipeng, Zhang Kai, Hou Chaoqun, Miao Yi, Guo Feng and Li Qiang
    Citation: BMC Cancer 2023 23:548
    Content type: Research Published on:

  47. Immune-checkpoint inhibitors (ICIs) have revolutionized the treatment of hepatocellular carcinoma (HCC). However, long-term survival outcomes and treatment response of HCC patients undergoing immunotherapy is ...

    Authors: Hong-Fei Zhu, Jin-Kai Feng, Yan-Jun Xiang, Kang Wang, Li-Ping Zhou, Zong-Han Liu, Yu-Qiang Cheng, Jie Shi, Wei-Xing Guo and Shu-Qun Cheng
    Citation: BMC Cancer 2023 23:547
    Content type: Research Published on:

  48. Neoadjuvant chemoradiation(nCRT) has been considered the preferred initial treatment strategy for distal rectal cancer. Advantages of this approach include improved local control after radical surgery but also...

    Authors: Angelita Habr-Gama, Guilherme Pagin São Julião, Cinthia D. Ortega, Bruna Borba Vailati, Sergio Araujo, Thiago Jorge, Jorge Sabbaga, Gustavo L. Rossi, Renata D’Alpino, Fabio Roberto Kater, Patricia Bailão Aguilar, Adrian Mattacheo and Rodrigo Oliva Perez
    Citation: BMC Cancer 2023 23:546
    Content type: Study protocol Published on:

  49. Anti−vascular endothelial growth factors (VEGFs) treatment has been associated with an increased risk of thromboembolic events. Therefore, the use of anti−VEGFs for patients with colorectal cancers (CRC) has r...

    Authors: Wan-Ju Annabelle Lee, Wei-Pang Chung, Shih-Chieh Shao, Edward Chia-Cheng Lai, Yi-Chen Chen and Chung-Han Ho
    Citation: BMC Cancer 2023 23:545
    Content type: Research Published on:

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