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  1. MANTICORE 101 - Breast (Multidisciplinary Approach to Novel Therapies in Cardiology Oncology Research) is a randomized trial to determine if conventional heart failure pharmacotherapy (angiotensin converting e...

    Authors: Edith Pituskin, Mark Haykowsky, John R Mackey, Richard B Thompson, Justin Ezekowitz, Sheri Koshman, Gavin Oudit, Kelvin Chow, Joseph J Pagano and Ian Paterson
    Citation: BMC Cancer 2011 11:318
    Content type: Study protocol Published on:

  2. Prostate cancer is the most common male cancer in developed countries and diagnosis and treatment carries with it substantial morbidity and related unmet supportive care needs. These difficulties may be amplif...

    Authors: Suzanne K Chambers, Robert U Newton, Afaf Girgis, Lisa Nielsen, Stephen Lepore, Cathrine Mihalopoulos, RA Gardiner, Daniel A Galvão and Stefano Occhipinti
    Citation: BMC Cancer 2011 11:317
    Content type: Study protocol Published on:

  3. Patients with cancer have an increased risk of VTE. We compared VTE rates and bleeding complications in 1) cancer patients receiving LMWH or UFH and 2) patients with or without cancer.

    Authors: Sylvia Haas, Sebastian M Schellong, Ulrich Tebbe, Horst-Eberhard Gerlach, Rupert Bauersachs, Nima Melzer, Claudia Abletshauser, Christian Sieder, Peter Bramlage and Hanno Riess
    Citation: BMC Cancer 2011 11:316
    Content type: Research article Published on:

  4. Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect. One strategy targeting this metabolic phenotype is glucose res...

    Authors: Gabriele D Maurer, Daniel P Brucker, Oliver Bähr, Patrick N Harter, Elke Hattingen, Stefan Walenta, Wolfgang Mueller-Klieser, Joachim P Steinbach and Johannes Rieger
    Citation: BMC Cancer 2011 11:315
    Content type: Research article Published on:

  5. Mammographic density (MD) and malignant-appearing microcalcifications (MAMCs) represent the earliest mammographic findings of non-palpable breast carcinomas. Matrix proteoglycans versican and decorin are frequ...

    Authors: Spyros S Skandalis, Vassiliki T Labropoulou, Panagiota Ravazoula, Eleni Likaki-Karatza, Katalin Dobra, Haralabos P Kalofonos, Nikos K Karamanos and Achilleas D Theocharis
    Citation: BMC Cancer 2011 11:314
    Content type: Research article Published on:

  6. This phase 1b study assessed the maximum tolerated dose (MTD), safety, and pharmacokinetics of motesanib (a small-molecule antagonist of VEGF receptors 1, 2, and 3; platelet-derived growth factor receptor; and...

    Authors: Dusan Kotasek, Niall Tebbutt, Jayesh Desai, Stephen Welch, Lillian L Siu, Sheryl McCoy, Yu-Nien Sun, Jessica Johnson, Adeboye H Adewoye and Timothy Price
    Citation: BMC Cancer 2011 11:313
    Content type: Research article Published on:

  7. Monocarboxylate transporters (MCTs) are transmembrane proteins involved in the transport of monocarboxylates across the plasma membrane, which appear to play an important role in solid tumours, however the rol...

    Authors: Nelma Pértega-Gomes, José R Vizcaíno, Vera Miranda-Gonçalves, Céline Pinheiro, Joana Silva, Helena Pereira, Pedro Monteiro, Rui M Henrique, Rui M Reis, Carlos Lopes and Fátima Baltazar
    Citation: BMC Cancer 2011 11:312
    Content type: Research article Published on:

  8. Strategies for cancer reduction and management are targeted at both individual and area levels. Area-level strategies require careful understanding of geographic differences in cancer incidence, in particular ...

    Authors: Susanna M Cramb, Kerrie L Mengersen and Peter D Baade
    Citation: BMC Cancer 2011 11:311
    Content type: Research article Published on:

  9. Open transthoracic oesophagectomy is the standard treatment for infracarinal resectable oesophageal carcinomas, although it is associated with high mortality and morbidity rates of 2 to 10% and 30 to 50%, resp...

    Authors: Nicolas Briez, Guillaume Piessen, Franck Bonnetain, Cécile Brigand, Nicolas Carrere, Denis Collet, Christophe Doddoli, Renaud Flamein, Jean-Yves Mabrut, Bernard Meunier, Simon Msika, Thierry Perniceni, Frédérique Peschaud, Michel Prudhomme, Jean-Pierre Triboulet and Christophe Mariette
    Citation: BMC Cancer 2011 11:310
    Content type: Study protocol Published on:

  10. E7080 is an orally active multi-targeted kinase inhibitor whose targets include vascular endothelial growth factor receptors (VEGFR), fibroblast growth factor receptor (FGFR) and platelet derived growth factor...

    Authors: Hilary Glen, Susan Mason, Hitesh Patel, Kenneth Macleod and Valerie G Brunton
    Citation: BMC Cancer 2011 11:309
    Content type: Research article Published on:

  11. Ovarian cancer is the most deadly gynecological cancer with a very poor prognosis. Xenograft mouse models have proven to be one very useful tool in testing candidate therapeutic agents and gene function in vivo. ...

    Authors: Ashley Stuckey, Andrew Fischer, Daniel H Miller, Sara Hillenmeyer, Kyu K Kim, Anna Ritz, Rakesh K Singh, Benjamin J Raphael, Laurent Brard and Alexander S Brodsky
    Citation: BMC Cancer 2011 11:308
    Content type: Research article Published on:

  12. Polysaccharides extracted from the Phellinus linteus (PL) mushroom are known to possess anti-tumor effects. However, the molecular mechanisms responsible for the anti-tumor properties of PL remain to be explored....

    Authors: Kyoung-Sub Song, Ge Li, Jong-Seok Kim, Kaipeng Jing, Tae-Dong Kim, Jin-Pyo Kim, Seung-Bo Seo, Jae-Kuk Yoo, Hae-Duck Park, Byung-Doo Hwang, Kyu Lim and Wan-Hee Yoon
    Citation: BMC Cancer 2011 11:307
    Content type: Research article Published on:

  14. MUTYH-associated polyposis (MAP) is an autosomal recessive form of intestinal polyposis predisposing to colorectal carcinoma. High resolution melting analysis (HRMA) is a mutation scanning method that allows det...

    Authors: Rossella Tricarico, Francesca Crucianelli, Antonio Alvau, Claudio Orlando, Roberta Sestini, Francesco Tonelli, Rosa Valanzano and Maurizio Genuardi
    Citation: BMC Cancer 2011 11:305
    Content type: Technical advance Published on:

  15. Breast cancer is the second leading cause of cancer-related death in women in the United States. During the advanced stages of disease, many breast cancer patients suffer from bone metastasis. These metastases...

    Authors: Anguraj Sadanandam, Mitsuru Futakuchi, Costas A Lyssiotis, William J Gibb and Rakesh K Singh
    Citation: BMC Cancer 2011 11:304
    Content type: Research article Published on:

  16. Leptin is a pleiotropic hormone whose mitogenic and angiogenic activity has been implicated in the development and progression of several malignancies, including brain tumors. In human brain cancer, especially...

    Authors: Rita Ferla, Maria Bonomi, Laszlo Otvos Jr and Eva Surmacz
    Citation: BMC Cancer 2011 11:303
    Content type: Research article Published on:

  17. Fatty acid binding proteins (FABP) play an important role in carcinogenesis. Modified FABP expression patterns were described for prostate, bladder and for renal cell carcinoma. Studies on metabolic relationsh...

    Authors: Angelika Tölle, Saba Suhail, Monika Jung, Klaus Jung and Carsten Stephan
    Citation: BMC Cancer 2011 11:302
    Content type: Research article Published on:

  18. Multiple myeloma is an incurable disease requiring the development of effective therapies which can be used clinically. We have elucidated the potential for manipulating the cAMP signaling pathway as a target ...

    Authors: Virginie Follin-Arbelet, Peter O Hofgaard, Harald Hauglin, Soheil Naderi, Anders Sundan, Rune Blomhoff, Bjarne Bogen and Heidi K Blomhoff
    Citation: BMC Cancer 2011 11:301
    Content type: Research article Published on:

  19. Emmprin, a glycoprotein containing two Ig domains, is enriched on tumor cell surfaces and stimulates matrix metalloproteinase (MMP) production by adjacent stromal cells. Its first Ig domain (ECI) contains the ...

    Authors: Takehito Kawakami, Tetsuro Sameshima, Hironobu Hojo, Kaori Koga, Yoshiaki Nakahara, Bryan P Toole, Junji Suzumiya, Yasunori Okada, Akinori Iwasaki and Kazuki Nabeshima
    Citation: BMC Cancer 2011 11:300
    Content type: Research article Published on:

  20. A breast cancer prognostic tool should ideally be applicable to all types of invasive breast lesions. A number of studies have shown histopathological grade to be an independent prognostic factor in breast can...

    Authors: André Albergaria, Sara Ricardo, Fernanda Milanezi, Vítor Carneiro, Isabel Amendoeira, Daniella Vieira, Jorge Cameselle-Teijeiro and Fernando Schmitt
    Citation: BMC Cancer 2011 11:299
    Content type: Research article Published on:

  21. Improving the coordination of cancer care is a priority area for service improvement. However, quality improvement initiatives are hindered by the lack of accurate and reliable measures of this aspect of cance...

    Authors: Jane M Young, Jennifer Walsh, Phyllis N Butow, Michael J Solomon and Joanne Shaw
    Citation: BMC Cancer 2011 11:298
    Content type: Research article Published on:

  22. Since transitional cell carcinoma (TCC) of the upper urinary tract is a relatively uncommon malignancy, the role of adjuvant radiotherapy is unknown.

    Authors: Bing Chen, Zhao-Chong Zeng, Guo-Min Wang, Li Zhang, Zong-Ming Lin, Li-An Sun, Tong-Yu Zhu, Li-Li Wu, Jian-Ying Zhang and Yuan Ji
    Citation: BMC Cancer 2011 11:297
    Content type: Research article Published on:

  23. Systemic therapy for cancer metastatic lesions is difficult and generally renders a poor clinical response. Structural analogs of cisplatin, the most widely used synthetic metal complexes, show toxic side-effe...

    Authors: Fabiana A Serrano, Alisson L Matsuo, Priscila T Monteforte, Alexandre Bechara, Soraya S Smaili, Débora P Santana, Tiago Rodrigues, Felipe V Pereira, Luis S Silva, Joel Machado Jr, Edson L Santos, João B Pesquero, Rafael M Martins, Luiz R Travassos, Antonio CF Caires and Elaine G Rodrigues
    Citation: BMC Cancer 2011 11:296
    Content type: Research article Published on:

  24. Data on sequential therapy in patients with metastatic renal cell carcinoma (mRCC) and intrinsic resistance to receptor tyrosine kinase inhibitor (rTKI) treatment remains vague.

    Authors: Jonas Busch, Christoph Seidel, Steffen Weikert, Ingmar Wolff, Carsten Kempkensteffen, Lisa Weinkauf, Stefan Hinz, Ahmed Magheli, Kurt Miller and Viktor Grünwald
    Citation: BMC Cancer 2011 11:295
    Content type: Research article Published on:

  25. In ovarian cancer, the reported rate of EGFR expression varies between 4-70% depending on assessment method and data on patient outcome are conflicting. Methods: In this study we investigated EGFR expression a...

    Authors: Aurelia Noske, Michael Schwabe, Wilko Weichert, Silvia Darb-Esfahani, Ann-Christin Buckendahl, Jalid Sehouli, Elena I Braicu, Jan Budczies, Manfred Dietel and Carsten Denkert
    Citation: BMC Cancer 2011 11:294
    Content type: Research article Published on:

  27. Molecular classification of breast cancer is an important prognostic factor. The distribution of molecular subtypes of breast cancer and their prognostic value has not been well documented in Asians.

    Authors: Yinghao Su, Ying Zheng, Wei Zheng, Kai Gu, Zhi Chen, Guoliang Li, Qiuyin Cai, Wei Lu and Xiao Ou Shu
    Citation: BMC Cancer 2011 11:292
    Content type: Research article Published on:

  28. To evaluate the association between polymorphisms involved in DNA repair and oxidative stress genes and mean dose to whole breast on acute skin reactions (erythema) in breast cancer (BC) patients following sin...

    Authors: Elisabetta Falvo, Lidia Strigari, Gennaro Citro, Carolina Giordano, Stefano Arcangeli, Antonella Soriani, Daniela D'Alessio, Paola Muti, Giovanni Blandino, Isabella Sperduti and Paola Pinnarò
    Citation: BMC Cancer 2011 11:291
    Content type: Research article Published on:

  29. CD44, a hyaluronan (HA) receptor, is a multistructural and multifunctional cell surface molecule involved in cell proliferation, cell differentiation, cell migration, angiogenesis, presentation of cytokines, c...

    Authors: Xin Jian Fang, Hua Jiang, Xv Peng Zhao and Wei Mei Jiang
    Citation: BMC Cancer 2011 11:290
    Content type: Research article Published on:

  30. Platinum agents have shown demonstrable activity in the treatment of patients with platinum resistant, recurrent ovarian cancer when delivered in a "dose-dense" fashion. However, the development of thrombocyto...

    Authors: Rohini Sharma, Janet Graham, Sarah Blagden and Hani Gabra
    Citation: BMC Cancer 2011 11:289
    Content type: Research article Published on:

  31. XELOX (capecitabine + oxaliplatin) and FOLFOX 4 (5-FU + folinic acid + oxaliplatin) have shown similar improvements in survival in patients with metastatic colorectal cancer (MCRC). A US cost-minimization stud...

    Authors: Vicki C Tse, Wai Tong Ng, Victor Lee, Anne WM Lee, Daniel TT Chua, June Chau and Sarah M McGhee
    Citation: BMC Cancer 2011 11:288
    Content type: Research article Published on:

  32. Weight loss in overweight or obese breast cancer patients is associated with an improved prognosis for long term survival. However, it is not clear whether the macronutrient composition of the chosen weight lo...

    Authors: Scot M Sedlacek, Mary C Playdon, Pamela Wolfe, John N McGinley, Mark R Wisthoff, Elizabeth A Daeninck, Weiqin Jiang, Zongjian Zhu and Henry J Thompson
    Citation: BMC Cancer 2011 11:287
    Content type: Study protocol Published on:

  33. The utility of circulating angiogenic cytokines (CAC) as biomarkers in pancreatic cancer has not been clarified yet. We investigated the expression and prognostic associations of seven CAC in patients with pan...

    Authors: Nuh N Rahbari, Thomas Schmidt, Christine S Falk, Ulf Hinz, Magdalene Herber, Ulrich Bork, Markus W Büchler, Jürgen Weitz and Moritz Koch
    Citation: BMC Cancer 2011 11:286
    Content type: Research article Published on:

  34. Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors ...

    Authors: Nicolas Porquet, Andrée Poirier, François Houle, Anne-Laure Pin, Stéphanie Gout, Pierre-Luc Tremblay, Éric R Paquet, Roscoe Klinck, François A Auger and Jacques Huot
    Citation: BMC Cancer 2011 11:285
    Content type: Research article Published on:

  35. Adherence to pharmacological therapy is a complex and multi-factorial issue that can substantially alter the outcome of treatment. It has been shown that cancer patients, especially when using long-term medica...

    Authors: Lonneke Timmers, Christel CLM Boons, Dirk Mangnus, Josee E Moes, Eleonora L Swart, Epie Boven, Egbert F Smit and Jacqueline G Hugtenburg
    Citation: BMC Cancer 2011 11:284
    Content type: Study protocol Published on:

  36. Using a longitudinal design, aim of this study was to investigate the relation between mental adjustment to cancer and anxiety, depression, health-related quality of life (HRQL) and survival in patients treate...

    Authors: Mia Johansson, Anna Rydén and Caterina Finizia
    Citation: BMC Cancer 2011 11:283
    Content type: Research article Published on:

  37. France stands among high-risk areas for colorectal cancer. Different trends in CRC incidence are reported around the world. The aim of this study was to provide temporal trends in CRC incidence over a 30-year ...

    Authors: Marion Chauvenet, Vanessa Cottet, Côme Lepage, Valérie Jooste, Jean Faivre and Anne-Marie Bouvier
    Citation: BMC Cancer 2011 11:282
    Content type: Research article Published on:

  38. Obesity and related metabolic abnormalities, including inflammation and lipid accumulation in the liver, play a role in liver carcinogenesis. Adipocytokine imbalances, such as decreased serum adiponectin level...

    Authors: Masahito Shimizu, Yoichi Yasuda, Hiroyasu Sakai, Masaya Kubota, Daishi Terakura, Atsushi Baba, Tomohiko Ohno, Takahiro Kochi, Hisashi Tsurumi, Takuji Tanaka and Hisataka Moriwaki
    Citation: BMC Cancer 2011 11:281
    Content type: Research article Published on:

  39. Since a substantial percentage of ovarian cancers express gonadotropin receptors and are responsive to the relatively high concentrations of pituitary gonadotropins during the postmenopausal years, it has been...

    Authors: Juan Cui, Brooke M Miner, Joanna B Eldredge, Susanne W Warrenfeltz, Phuongan Dam, Ying Xu and David Puett
    Citation: BMC Cancer 2011 11:280
    Content type: Research article Published on:

  40. After primary treatment for breast cancer, patients are recommended to use hospital follow-up care routinely. Long-term data on the utilization of this follow-up care are relatively rare.

    Authors: Wenli Lu, Liesbeth Jansen, Michael Schaapveld, Peter C Baas, Theo Wiggers and Geertruida H De Bock
    Citation: BMC Cancer 2011 11:279
    Content type: Research article Published on:

  41. Inter-individual variation in DNA repair capacity is thought to modulate breast cancer risk. The phenotypic mutagen sensitivity assay (MSA) measures DNA strand breaks in lymphocytes; women with familial and sp...

    Authors: Luisel J Ricks-Santi, Lara E Sucheston, Yang Yang, Jo L Freudenheim, Claudine J Isaacs, Marc D Schwartz, Ramona G Dumitrescu, Catalin Marian, Jing Nie, Dominica Vito, Stephen B Edge and Peter G Shields
    Citation: BMC Cancer 2011 11:278
    Content type: Research article Published on:

  43. It is well known that carcinomas of the gastrointestinal tract are frequently associated with peritoneal carcinomatosis. In contrast to that entity extensive involvement of the peritoneal cavity with malignant...

    Authors: Yun Gi Kim, Ji Yeon Baek, Sun Young Kim, Dong Hyeon Lee, Weon Seo Park, Youngmee Kwon, Min Ju Kim, Jeehoon Kang and Joo Myung Lee
    Citation: BMC Cancer 2011 11:276
    Content type: Case report Published on:

  44. Aldehyde deyhdrogenase 1 (ALDH1) has been characterised as a cancer stem cell marker in different types of tumours. Additionally, it plays a pivotal role in gene regulation and endows tumour cells with augment...

    Authors: Christoph Kahlert, Frank Bergmann, Janine Beck, Thilo Welsch, Carolin Mogler, Esther Herpel, Shamik Dutta, Thomas Niemietz, Moritz Koch and Jürgen Weitz
    Citation: BMC Cancer 2011 11:275
    Content type: Research article Published on:

  45. Targeting of the renin angiotensin system (RAS) reduces tumour growth in experimental models of cancer. We aimed to establish if combined targeting of the 'classical' and 'alternative' arms of the RAS could re...

    Authors: Eleanor I Ager, Shu Wen Wen, Joyna Chan, Way W Chong, Jaclyn H Neo and Christopher Christophi
    Citation: BMC Cancer 2011 11:274
    Content type: Research article Published on:

  46. Members of the urokinase-type plasminogen activator (uPA) system are up-regulated in various solid malignant tumors. High antigen levels of uPA, its inhibitor PAI-1 and its receptor uPAR have recently been sho...

    Authors: Matthias Kotzsch, Viktor Magdolen, Thomas Greither, Matthias Kappler, Matthias Bache, Christine Lautenschläger, Susanne Füssel, Alexander W Eckert, Thomas Luther, Gustavo Baretton, Peter Würl and Helge Taubert
    Citation: BMC Cancer 2011 11:273
    Content type: Research article Published on:

  48. Our previous studies showed that ZBTB20, a new BTB/POZ-domain gene, could negatively regulate α feto-protein and other liver-specific genes, concerning such as bio-transformation, glucose metabolism and the re...

    Authors: Qing Wang, Ye-xiong Tan, Yi-bin Ren, Li-wei Dong, Zhi-fang Xie, Liang Tang, Dan Cao, Wei-ping Zhang, He-ping Hu and Hong-yang Wang
    Citation: BMC Cancer 2011 11:271
    Content type: Research article Published on:

  49. Myofibrillogenesis regulator 1 (MR-1) is overexpressed in human cancer cells and plays an essential role in cancer cell growth. However, the significance of MR-1 in human ovarian cancer has not yet been explor...

    Authors: Renquan Lu, Min Sun, Jingjing Feng, Xiang Gao and Lin Guo
    Citation: BMC Cancer 2011 11:270
    Content type: Research article Published on:

  50. 18-Fluorodeoxyglucose-PET (18F-FDG-PET) can be used for early response assessment in patients with locally advanced adenocarcinomas of the oesophagogastric junction (AEG) undergoing neoadjuvant chemotherapy. It h...

    Authors: Sylvie Lorenzen, Carl von Gall, Annika Stange, Georg M Haag, Jürgen Weitz, Uwe Haberkorn, Florian Lordick, Wilko Weichert, Ulrich Abel, Jürgen Debus, Dirk Jäger and Marc W Münter
    Citation: BMC Cancer 2011 11:266
    Content type: Study protocol Published on:

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