Roodman GD: Mechanisms of bone metastasis. The New England journal of medicine. 2004, 350 (16): 1655-1664.
Article
CAS
PubMed
Google Scholar
Coleman RE: Skeletal complications of malignancy. Cancer. 1997, 80 (8 Suppl): 1588-1594.
Article
CAS
PubMed
Google Scholar
Mundy GR: Mechanisms of bone metastasis. Cancer. 1997, 80 (8 Suppl): 1546-1556.
Article
CAS
PubMed
Google Scholar
Mundy GR: Metastasis to bone: causes, consequences and therapeutic opportunities. Nature reviews. 2002, 2 (8): 584-593.
CAS
PubMed
Google Scholar
Rose AA, Siegel PM: Emerging therapeutic targets in breast cancer bone metastasis. Future oncology (London, England). 6 (1): 55-74.
Suva LJ, Griffin RJ, Makhoul I: Mechanisms of bone metastases of breast cancer. Endocrine-related cancer. 2009, 16 (3): 703-713.
Article
CAS
PubMed
PubMed Central
Google Scholar
Arguello F, Baggs RB, Frantz CN: A murine model of experimental metastasis to bone and bone marrow. Cancer research. 1988, 48 (23): 6876-6881.
CAS
PubMed
Google Scholar
Harms JF, Welch DR: MDA-MB-435 human breast carcinoma metastasis to bone. Clinical & experimental metastasis. 2003, 20 (4): 327-334.
Article
CAS
Google Scholar
Thomas RJ, Guise TA, Yin JJ, Elliott J, Horwood NJ, Martin TJ, Gillespie MT: Breast cancer cells interact with osteoblasts to support osteoclast formation. Endocrinology. 1999, 140 (10): 4451-4458.
CAS
PubMed
Google Scholar
Yoneda T, Williams PJ, Hiraga T, Niewolna M, Nishimura R: A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro. J Bone Miner Res. 2001, 16 (8): 1486-1495.
Article
CAS
PubMed
Google Scholar
Lynch CC, Hikosaka A, Acuff HB, Martin MD, Kawai N, Singh RK, Vargo-Gogola TC, Begtrup JL, Peterson TE, Fingleton B, Shirai T, Matrisian LM, Futakuchi M: MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Cancer cell. 2005, 7 (5): 485-496.
Article
CAS
PubMed
Google Scholar
Futakuchi M, Nannuru KC, Varney ML, Sadanandam A, Nakao K, Asai K, Shirai T, Sato SY, Singh RK: Transforming growth factor-beta signaling at the tumor-bone interface promotes mammary tumor growth and osteoclast activation. Cancer science. 2009, 100 (1): 71-81.
Article
CAS
PubMed
Google Scholar
Nannuru KC, Futakuchi M, Sadanandam A, Wilson TJ, Varney ML, Myers KJ, Li X, Marcusson EG, Singh RK: Enhanced expression and shedding of receptor activator of NF-kappaB ligand during tumor-bone interaction potentiates mammary tumor-induced osteolysis. Clinical & experimental metastasis. 2009, 26 (7): 797-808.
Article
CAS
Google Scholar
Nannuru KC, Futakuchi M, Varney ML, Vincent TM, Marcusson EG, Singh RK: Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-beta signaling at the tumor-bone interface. Cancer research. 2010, 70 (9): 3494-3504.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wilson TJ, Nannuru KC, Futakuchi M, Sadanandam A, Singh RK: Cathepsin G enhances mammary tumor-induced osteolysis by generating soluble receptor activator of nuclear factor-kappaB ligand. Cancer research. 2008, 68 (14): 5803-5811.
Article
CAS
PubMed
Google Scholar
Aslakson CJ, Miller FR: Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor. Cancer research. 1992, 52 (6): 1399-1405.
CAS
PubMed
Google Scholar
Murphy BO, Joshi S, Kessinger A, Reed E, Sharp JG: A murine model of bone marrow micrometastasis in breast cancer. Clinical & experimental metastasis. 2002, 19 (7): 561-569.
Article
Google Scholar
Varney ML, Singh S, Backora M, Chen Z, Singh RK: Lymphangiogenesis and anti-tumor immune responses. Current molecular medicine. 2009, 9 (6): 694-701.
Article
CAS
PubMed
Google Scholar
Wilson CL, Miller CJ: Simpleaffy: a BioConductor package for Affymetrix Quality Control and data analysis. Bioinformatics (Oxford, England). 2005, 21 (18): 3683-3685.
Article
CAS
Google Scholar
Simon R, Lam A, Li MC, Ngan M, Menenzes S, Zhao Y: Analysis of gene expression data using BRB-ArrayTools. Cancer informatics. 2007, 3: 11-17.
PubMed
PubMed Central
Google Scholar
Barrett T, Troup DB, Wilhite SE, Ledoux P, Rudnev D, Evangelista C, Kim IF, Soboleva A, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Muertter RN, Edgar R: NCBI GEO: archive for high-throughput functional genomic data. Nucleic acids research. 2009, D885-890. 37 Database
Zhang XH, Wang Q, Gerald W, Hudis CA, Norton L, Smid M, Foekens JA, Massague J: Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer cell. 2009, 16 (1): 67-78.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lou Y, Preobrazhenska O, auf dem Keller U, Sutcliffe M, Barclay L, McDonald PC, Roskelley C, Overall CM, Dedhar S: Epithelial-mesenchymal transition (EMT) is not sufficient for spontaneous murine breast cancer metastasis. Dev Dyn. 2008, 237 (10): 2755-2768.
Article
CAS
PubMed
Google Scholar
Zhao B, Takami M, Yamada A, Wang X, Koga T, Hu X, Tamura T, Ozato K, Choi Y, Ivashkiv LB, Takayanagi H, Kamijo R: Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nature medicine. 2009, 15 (9): 1066-1071.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chin K, DeVries S, Fridlyand J, Spellman PT, Roydasgupta R, Kuo WL, Lapuk A, Neve RM, Qian Z, Ryder T, Chen F, Feiler H, Tokuyasu T, Kingsley C, Dairkee S, Meng Z, Chew K, Pinkel D, Jain A, Ljung BM, Esserman L, Albertson DG, Waldman FM, Gray JW: Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer cell. 2006, 10 (6): 529-541.
Article
CAS
PubMed
Google Scholar
Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, Speed T, Spellman PT, DeVries S, Lapuk A, Wang NJ, Kuo WL, Stilwell JL, Pinkel D, Albertson DG, Waldman FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, Gray JW: A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer cell. 2006, 10 (6): 515-527.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hoshida Y, Villanueva A, Kobayashi M, Peix J, Chiang DY, Camargo A, Gupta S, Moore J, Wrobel MJ, Lerner J, Reich M, Chan JA, Glickman JN, Ikeda K, Hashimoto M, Watanabe G, Daidone MG, Roayaie S, Schwartz M, Thung S, Salvesen HB, Gabriel S, Mazzaferro V, Bruix J, Friedman SL, Kumada H, Llovet JM, Golub TR: Gene expression in fixed tissues and outcome in hepatocellular carcinoma. The New England journal of medicine. 2008, 359 (19): 1995-2004.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hoshida Y: Nearest template prediction: a single-sample-based flexible class prediction with confidence assessment. PloS one. 2010, 5 (11): e15543-
Article
PubMed
PubMed Central
Google Scholar
Benito M, Parker J, Du Q, Wu J, Xiang D, Perou CM, Marron JS: Adjustment of systematic microarray data biases. Bioinformatics (Oxford, England). 2004, 20 (1): 105-114.
Article
CAS
Google Scholar
Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, Rasmussen KE, Jones LP, Assefnia S, Chandrasekharan S, Backlund MG, Yin Y, Khramtsov AI, Bastein R, Quackenbush J, Glazer RI, Brown PH, Green JE, Kopelovich L, Furth PA, Palazzo JP, Olopade OI, Bernard PS, Churchill GA, Van Dyke T, Perou CM: Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome biology. 2007, 8 (5): R76-
Article
PubMed
PubMed Central
Google Scholar
Hoshida Y, Brunet JP, Tamayo P, Golub TR, Mesirov JP: Subclass mapping: identifying common subtypes in independent disease data sets. PloS one. 2007, 2 (11): e1195-
Article
PubMed
PubMed Central
Google Scholar
Eisen MB, Spellman PT, Brown PO, Botstein D: Cluster analysis and display of genome-wide expression patterns. Proceedings of the National Academy of Sciences of the United States of America. 1998, 95 (25): 14863-14868.
Article
CAS
PubMed
PubMed Central
Google Scholar
Reich M, Liefeld T, Gould J, Lerner J, Tamayo P, Mesirov JP: GenePattern 2.0. Nature genetics. 2006, 38 (5): 500-501.
Article
CAS
PubMed
Google Scholar
Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G: Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nature genetics. 2000, 25 (1): 25-29.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kanehisa M, Goto S, Furumichi M, Tanabe M, Hirakawa M: KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic acids research. D355-360. 38 Database
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP: Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences of the United States of America. 2005, 102 (43): 15545-15550.
Article
CAS
PubMed
PubMed Central
Google Scholar
Goeman JJ, Oosting J, Cleton-Jansen AM, Anninga JK, van Houwelingen HC: Testing association of a pathway with survival using gene expression data. Bioinformatics (Oxford, England). 2005, 21 (9): 1950-1957.
Article
CAS
Google Scholar
Goeman JJ, van de Geer SA, de Kort F, van Houwelingen HC: A global test for groups of genes: testing association with a clinical outcome. Bioinformatics (Oxford, England). 2004, 20 (1): 93-99.
Article
CAS
Google Scholar
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR: The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (New York, NY. 2006, 313 (5795): 1929-1935.
Article
CAS
Google Scholar
Ramaswamy S, Ross KN, Lander ES, Golub TR: A molecular signature of metastasis in primary solid tumors. Nature genetics. 2003, 33 (1): 49-54.
Article
CAS
PubMed
Google Scholar
Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM: OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999, 397 (6717): 315-323.
Article
CAS
PubMed
Google Scholar
Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ: Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. 1998, 93 (2): 165-176.
Article
CAS
PubMed
Google Scholar
Boyle WJ, Simonet WS, Lacey DL: Osteoclast differentiation and activation. Nature. 2003, 423 (6937): 337-342.
Article
CAS
PubMed
Google Scholar
Ogata H, Goto S, Sato K, Fujibuchi W, Bono H, Kanehisa M: KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic acids research. 1999, 27 (1): 29-34.
Article
CAS
PubMed
PubMed Central
Google Scholar
Subramanian A, Kuehn H, Gould J, Tamayo P, Mesirov JP: GSEA-P: a desktop application for Gene Set Enrichment Analysis. Bioinformatics (Oxford, England). 2007, 23 (23): 3251-3253.
Article
CAS
Google Scholar
Brown AL, Wilkinson CR, Waterman SR, Kok CH, Salerno DG, Diakiw SM, Reynolds B, Scott HS, Tsykin A, Glonek GF, Goodall GJ, Solomon PJ, Gonda TJ, D'Andrea RJ: Genetic regulators of myelopoiesis and leukemic signaling identified by gene profiling and linear modeling. Journal of leukocyte biology. 2006, 80 (2): 433-447.
Article
CAS
PubMed
Google Scholar
Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordon-Cardo C, Guise TA, Massague J: A multigenic program mediating breast cancer metastasis to bone. Cancer cell. 2003, 3 (6): 537-549.
Article
CAS
PubMed
Google Scholar
Reddi AH, Roodman D, Freeman C, Mohla S: Mechanisms of tumor metastasis to the bone: challenges and opportunities. J Bone Miner Res. 2003, 18 (2): 190-194.
Article
CAS
PubMed
Google Scholar
Stoughton RB: Applications of DNA microarrays in biology. Annual review of biochemistry. 2005, 74: 53-82.
Article
CAS
PubMed
Google Scholar
Wang Y, Miller DJ, Clarke R: Approaches to working in high-dimensional data spaces: gene expression microarrays. British journal of cancer. 2008, 98 (6): 1023-1028.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sarkans U, Parkinson H, Lara GG, Oezcimen A, Sharma A, Abeygunawardena N, Contrino S, Holloway E, Rocca-Serra P, Mukherjee G, Shojatalab M, Kapushesky M, Sansone SA, Farne A, Rayner T, Brazma A: The ArrayExpress gene expression database: a software engineering and implementation perspective. Bioinformatics (Oxford, England). 2005, 21 (8): 1495-1501.
Article
CAS
Google Scholar
Allison DB, Cui X, Page GP, Sabripour M: Microarray data analysis: from disarray to consolidation and consensus. Nat Rev Genet. 2006, 7 (1): 55-65.
Article
CAS
PubMed
Google Scholar
Padua D, Massague J: Roles of TGFbeta in metastasis. Cell research. 2009, 19 (1): 89-102.
Article
CAS
PubMed
Google Scholar
Neuhaus H, Rosen V, Thies RS: Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily. Mechanisms of development. 1999, 80 (2): 181-184.
Article
CAS
PubMed
Google Scholar
Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T: USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney. Biochemical and biophysical research communications. 2004, 316 (2): 490-500.
Article
CAS
PubMed
Google Scholar
Yanagita M: BMP modulators regulate the function of BMP during body patterning and disease progression. BioFactors (Oxford, England). 2009, 35 (2): 113-119.
Article
CAS
Google Scholar
Krishnan V, Bryant HU, Macdougald OA: Regulation of bone mass by Wnt signaling. The Journal of clinical investigation. 2006, 116 (5): 1202-1209.
Article
CAS
PubMed
PubMed Central
Google Scholar
Voorzanger-Rousselot N, Goehrig D, Journe F, Doriath V, Body JJ, Clezardin P, Garnero P: Increased Dickkopf-1 expression in breast cancer bone metastases. British journal of cancer. 2007, 97 (7): 964-970.
CAS
PubMed
PubMed Central
Google Scholar
Glass DA, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G: Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Developmental cell. 2005, 8 (5): 751-764.
Article
CAS
PubMed
Google Scholar
Baron R, Rawadi G: Targeting the Wnt/beta-catenin pathway to regulate bone formation in the adult skeleton. Endocrinology. 2007, 148 (6): 2635-2643.
Article
CAS
PubMed
Google Scholar
Nakanishi R, Akiyama H, Kimura H, Otsuki B, Shimizu M, Tsuboyama T, Nakamura T: Osteoblast-targeted expression of Sfrp4 in mice results in low bone mass. J Bone Miner Res. 2008, 23 (2): 271-277.
Article
CAS
PubMed
Google Scholar
Katoh M: Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer. International journal of oncology. 2001, 19 (5): 1003-1007.
CAS
PubMed
Google Scholar
Lako M, Strachan T, Curtis AR, Lindsay S: Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24. Genomics. 1996, 35 (2): 386-388.
Article
CAS
PubMed
Google Scholar
Ernst ME, Moser M: Use of diuretics in patients with hypertension. The New England journal of medicine. 2009, 361 (22): 2153-2164.
Article
CAS
PubMed
Google Scholar
Brickman AS, Massry SG, Coburn JW: changes in serum and urinary calcium during treatment with hydrochlorothiazide: studies on mechanisms. The Journal of clinical investigation. 1972, 51 (4): 945-954.
Article
CAS
PubMed
PubMed Central
Google Scholar
Gamba G: Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters. Physiological reviews. 2005, 85 (2): 423-493.
Article
CAS
PubMed
Google Scholar
Jones G, Nguyen T, Sambrook PN, Eisman JA: Thiazide diuretics and fractures: can meta-analysis help?. J Bone Miner Res. 1995, 10 (1): 106-111.
CAS
PubMed
Google Scholar
LaCroix AZ, Wienpahl J, White LR, Wallace RB, Scherr PA, George LK, Cornoni-Huntley J, Ostfeld AM: Thiazide diuretic agents and the incidence of hip fracture. The New England journal of medicine. 1990, 322 (5): 286-290.
Article
CAS
PubMed
Google Scholar
Wasnich RD, Benfante RJ, Yano K, Heilbrun L, Vogel JM: Thiazide effect on the mineral content of bone. The New England journal of medicine. 1983, 309 (6): 344-347.
Article
CAS
PubMed
Google Scholar
Dvorak MM, De Joussineau C, Carter DH, Pisitkun T, Knepper MA, Gamba G, Kemp PJ, Riccardi D: Thiazide diuretics directly induce osteoblast differentiation and mineralized nodule formation by interacting with a sodium chloride co-transporter in bone. J Am Soc Nephrol. 2007, 18 (9): 2509-2516.
Article
CAS
PubMed
PubMed Central
Google Scholar