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  1. Although Muscle Invasive Bladder Cancer (MIBC) is increasing in incidence, treatment has largely remained limited to radical cystectomy with or without cisplatin-based neoadjuvant and/or adjuvant chemotherapy....

    Authors: Vishal Vashistha, David I Quinn, Tanya B Dorff and Siamak Daneshmand
    Citation: BMC Cancer 2014 14:966
    Content type: Research article Published on:

  2. DEK is a transcription factor involved in stabilization of heterochromatin and cruciform structures. It plays an important role in development and progression of different types of cancer. This study aims to a...

    Authors: Javier Martinez-Useros, Maria Rodriguez-Remirez, Aurea Borrero-Palacios, Irene Moreno, Arancha Cebrian, Teresa Gomez del Pulgar, Laura del Puerto-Nevado, Ricardo Vega-Bravo, Alberto Puime-Otin, Nuria Perez, Sandra Zazo, Clara Senin, Maria J Fernandez-Aceñero, Maria S Soengas, Federico Rojo and Jesus Garcia-Foncillas
    Citation: BMC Cancer 2014 14:965
    Content type: Research article Published on:

  3. Annexin A1 (ANXA1), a 37 kDa multifunctional protein, is over-expressed in tissues from patients of pancreatic carcinoma (PC) where the protein seems to be associated with malignant transformation and poor pro...

    Authors: Raffaella Belvedere, Valentina Bizzarro, Ada Popolo, Fabrizio Dal Piaz, Michele Vasaturo, Paola Picardi, Luca Parente and Antonello Petrella
    Citation: BMC Cancer 2014 14:961
    Content type: Research article Published on:

  4. Metalloproteinases (MMPs) and their tissue inhibitors of metalloproteinases (TIMPs) are involved in several key pathways of tumor growth, invasion and metastasis, but little is known about their expression acc...

    Authors: Ga-Eon Kim, Ji Shin Lee, Yoo-Duk Choi, Kyung-Hwa Lee, Jae Hyuk Lee, Jong Hee Nam, Chan Choi, Sung Sun Kim, Min Ho Park, Jung Han Yoon and Sun-Seog Kweon
    Citation: BMC Cancer 2014 14:959
    Content type: Research article Published on:

  5. Breast cancer is a heterogeneous disease displaying distinct molecular features and clinical outcome. The molecular profile of triple-negative breast cancers (TNBCs) overlaps with that of basal-like breast can...

    Authors: Kai Doberstein, Karin Milde-Langosch, Niko P Bretz, Uwe Schirmer, Ayelet Harari, Isabell Witzel, Alon Ben-Arie, Michael Hubalek, Elisabeth Müller-Holzner, Susanne Reinold, Alain G Zeimet, Peter Altevogt and Mina Fogel
    Citation: BMC Cancer 2014 14:958
    Content type: Research article Published on:

  6. NKG2D (natural killer group 2, member D) is thought to play an important role in mediating the activation of anticancer immune response. Expression of NKG2D ligands (NKG2DLs) is pronounced in malignancies and ...

    Authors: Hanbyoul Cho, Joon-Yong Chung, Sunghoon Kim, Till Braunschweig, Tae Heung Kang, Jennie Kim, Eun Joo Chung, Stephen M Hewitt and Jae-Hoon Kim
    Citation: BMC Cancer 2014 14:957
    Content type: Research article Published on:

  7. Our previous studies found the high prevalence of depression and anxiety among Chinese cancer patients, and many empirical studies have been conducted to evaluate the effects of psychological interventions on ...

    Authors: Yi-Long Yang, Guo-Yuan Sui, Guang-Cong Liu, De-Sheng Huang, Si-Meng Wang and Lie Wang
    Citation: BMC Cancer 2014 14:956
    Content type: Research article Published on:

  8. Cancer-associated fibroblasts and high mobility group box 1 (HMGB1) protein have been suggested to mediate cancer progression and chemotherapy resistance. The role of such fibroblasts in HMGB1 production in br...

    Authors: Kamolporn Amornsupak, Tonkla Insawang, Peti Thuwajit, Pornchai O-Charoenrat, Suzanne A Eccles and Chanitra Thuwajit
    Citation: BMC Cancer 2014 14:955
    Content type: Research article Published on:

  9. Neoadjuvant Chemotherapy (NC) including trastuzumab induces a high rate of pathological Complete Responses (pCR) in patients with locally advanced HER2-overexpressing Breast Cancer (BC), but is penalized by a ...

    Authors: Gianmaria Miolo, Elena Muraro, Debora Martorelli, Davide Lombardi, Simona Scalone, Simon Spazzapan, Samuele Massarut, Tiziana Perin, Elda Viel, Elisa Comaro, Renato Talamini, Ettore Bidoli, Elisa Turchet, Diana Crivellari and Riccardo Dolcetti
    Citation: BMC Cancer 2014 14:954
    Content type: Research article Published on:

  10. The IFCT-GFPC 0502 phase III study reported prolongation of progression-free survival with gemcitabine or erlotinib maintenance vs. observation after cisplatin–gemcitabine induction chemotherapy for advanced non-...

    Authors: Isabelle Borget, Maurice Pérol, David Pérol, Armelle Lavolé, Laurent Greillier, Pascal Dô, Virginie Westeel, Jacky Crequit, Hervé Léna, Isabelle Monnet, Hervé Le Caer, Pierre Fournel, Lionel Falchero, Michel Poudenx, Fabien Vaylet, Sylvie Chabaud…
    Citation: BMC Cancer 2014 14:953
    Content type: Research article Published on:

  11. Cyclooxygenases (COX) play a key role in prostaglandin metabolism and are important for tumor development and progression. The aim of this study was to analyze the prognostic impact of COX-2 expression in a co...

    Authors: Isabel Sicking, Karlien Rommens, Marco J Battista, Daniel Böhm, Susanne Gebhard, Antje Lebrecht, Cristina Cotarelo, Gerald Hoffmann, Jan G Hengstler and Marcus Schmidt
    Citation: BMC Cancer 2014 14:952
    Content type: Research article Published on:

  12. Cdk1 (cyclin-dependent kinase 1) is critical regulator of the G2-M checkpoint. Cyclin-dependent kinase pathways are considered possible targets for cancer treatment; however, the prognostic role of Cdk1 in col...

    Authors: Wen-Wei Sung, Yueh-Min Lin, Pei-Ru Wu, Hsu-Heng Yen, Hung-Wen Lai, Tzu-Cheng Su, Ren-Hung Huang, Chun-Kai Wen, Chia-Yu Chen, Chih-Jung Chen and Kun-Tu Yeh
    Citation: BMC Cancer 2014 14:951
    Content type: Research article Published on:

  13. HIF-1 (hypoxia-inducible factor 1) is a transcriptional activator that functions as a critical regulator of oxygen homeostasis. Recently, a large number of epidemiological studies have investigated the relatio...

    Authors: Qing Yan, Pin Chen, Songtao Wang, Ning Liu, Peng Zhao and Aihua Gu
    Citation: BMC Cancer 2014 14:950
    Content type: Research article Published on:

  14. Inhibition of metastasis through upregulation of immune surveillance is a major purpose of chemokine gene therapy. In this study, we focused on a membrane-bound chemokine CXCL16, which has shown a correlation ...

    Authors: Ji-Ye Kee, Aya Ito, Shozo Hojo, Isaya Hashimoto, Yoshiko Igarashi, Koichi Tsuneyama, Kazuhiro Tsukada, Tatsuro Irimura, Naotoshi Shibahara, Ichiro Takasaki, Akiko Inujima, Takashi Nakayama, Osamu Yoshie, Hiroaki Sakurai, Ikuo Saiki and Keiichi Koizumi
    Citation: BMC Cancer 2014 14:949
    Content type: Research article Published on:

  15. The value of adjuvant chemotherapy in colorectal cancer is well studied, and guidelines have been established. Little is known about how treatment guidelines are implemented in the everyday clinical setting.

    Authors: Elinor Bexe Lindskog, Katrín Ásta Gunnarsdóttir, Kristoffer Derwinger, Yvonne Wettergren, Bengt Glimelius and Karl Kodeda
    Citation: BMC Cancer 2014 14:948
    Content type: Research article Published on:

  16. The aim of this multicenter, retrospective study was to evaluate the efficacy and safety of metronomic oral cyclophosphamide (MOC) in heavily treated, relapsed ovarian cancer (ROC) patients.

    Authors: Gabriella Ferrandina, Giacomo Corrado, Floriana Mascilini, Paola Malaguti, Riccardo Samaritani, Mariagrazia Distefano, Valeria Masciullo, Alessia Di Legge, Antonella Savarese and Giovanni Scambia
    Citation: BMC Cancer 2014 14:947
    Content type: Research article Published on:

  17. Sarcoid-like reaction is often seen in various types of carcinoma, not only in the primary tumor, but also in regional lymph nodes, and can occur at any time, not only at the time of diagnosis, but also after ...

    Authors: Yota Kawasaki, Kosei Maemura, Hiroshi Kurahara, Yuko Mataki, Satoshi Iino, Masahiko Sakoda, Shinichi Ueno, Hiroyuki Shinchi, Sonshin Takao and Shoji Natsugoe
    Citation: BMC Cancer 2014 14:946
    Content type: Case report Published on:

  19. MYC family members are among the most frequently deregulated oncogenes in human cancers, yet direct therapeutic targeting of MYC in cancer has been challenging thus far. Synthetic lethality provides an opportu...

    Authors: Zongxiang Zhou, Manishha Patel, Nicholas Ng, Mindy H Hsieh, Anthony P Orth, John R Walker, Serge Batalov, Jennifer L Harris and Jun Liu
    Citation: BMC Cancer 2014 14:944
    Content type: Research article Published on:

  20. Smoke-free policies shown to reduce population exposure to secondhand smoke (SHS) are the norm in hospitals in many countries around the world. Armenia, a transition economy in the South Caucasus, has one of t...

    Authors: Narine K Movsisyan, Varduhi Petrosyan, Arusyak Harutyunyan, Diana Petrosyan and Frances Stillman
    Citation: BMC Cancer 2014 14:943
    Content type: Research article Published on:

  21. Breast cancer is a complex multifactorial genetic disease. Among other factors, race and, to an even greater extent, viruses are known to influence the development of this heterogeneous disease. It has been re...

    Authors: Alberto Cedro-Tanda, Alejandro Córdova-Solis, Teresa Juárez-Cedillo, Emmanuel Pina-Jiménez, Marta E Hernández-Caballero, Christian Moctezuma-Meza, Germán Castelazo-Rico, Alejandro Gómez-Delgado, Alejandro Cruz Monsalvo-Reyes, Fabio A Salamanca-Gómez, Diego J Arenas-Aranda and Normand García-Hernández
    Citation: BMC Cancer 2014 14:942
    Content type: Research article Published on:

  22. The aims of this study were to characterize the metabolite profiles of triple negative breast cancer (TNBC) and to investigate the metabolite profiles associated with human epidermal growth factor receptor-2/n...

    Authors: Maria D Cao, Santosh Lamichhane, Steinar Lundgren, Anna Bofin, Hans Fjøsne, Guro F Giskeødegård and Tone F Bathen
    Citation: BMC Cancer 2014 14:941
    Content type: Research article Published on:

  23. Real-world evidence lacks for clinical effectiveness and clinical toxicity associated with platinum-based doublets in the first-line setting for advanced non-squamous non-small cell lung cancer (advNS-NSCLC) i...

    Authors: Yan Wang, Jianhua Chen, Shengqi Wu, Chenping Hu, Xiaoling Li, Yuqin Wang, Yicheng Yang, Narayan Rajan, Yun Chen, Yi Chen, Zhuanzhuan Luo and Wendong Chen
    Citation: BMC Cancer 2014 14:940
    Content type: Research article Published on:

  24. Prostate cancer is the second leading cause of male cancer death in developed countries. Although the role of angiogenesis in its progression is well established, the efficacy of anti-angiogenic therapy is not...

    Authors: Alessandra Fiorio Pla, Alessia Brossa, Michela Bernardini, Tullio Genova, Guillaume Grolez, Arnaud Villers, Xavier Leroy, Natalia Prevarskaya, Dimitra Gkika and Benedetta Bussolati
    Citation: BMC Cancer 2014 14:939
    Content type: Research article Published on:

  25. Fibulin-5 has been considered as a tumor suppressor through inhibiting tumor growth and invasion. Reduced expression of Fibulin-5 is frequently observed in various human cancers. In this study, we investigate ...

    Authors: Kangsheng Tu, Changwei Dou, Xin Zheng, Chao Li, Wei Yang, Yingmin Yao and Qingguang Liu
    Citation: BMC Cancer 2014 14:938
    Content type: Research article Published on:

  26. In patients with ovarian cancer relapsing at least 6 months after end of primary treatment, the addition of paclitaxel to platinum treatment has been shown to improve survival but at the cost of significant ne...

    Authors: Yun Wang, Jørn Herrstedt, Hanne Havsteen, Rene DePoint Christensen, Mansoor Raza Mirza, Bente Lund, Johanna Maenpaa and Gunnar Kristensen
    Citation: BMC Cancer 2014 14:937
    Content type: Research article Published on:

  27. Breast cancer places a heavy burden on the Australian healthcare system, but information about the actual number of women living with breast cancer and their current or future health service needs is limited. ...

    Authors: Xue Qin Yu, Roberta De Angelis, Qingwei Luo, Clare Kahn, Nehmat Houssami and Dianne L O’Connell
    Citation: BMC Cancer 2014 14:936
    Content type: Research article Published on:

  28. Due to the lack of ERα, triple negative breast cancers (TNBCs) are not susceptible to endocrine therapy using antiestrogens. However, the majority of TNBCs express the membrane bound estrogen receptor GPR30. W...

    Authors: Rainer Girgert, Günter Emons and Carsten Gründker
    Citation: BMC Cancer 2014 14:935
    Content type: Research article Published on:

  29. Although radiotherapy is a key component of curative-intent treatment for locally advanced, unresectable non-small cell lung cancer (NSCLC), it can be associated with substantial pulmonary toxicity in some pat...

    Authors: Douglas A Hoover, Dante PI Capaldi, Khadija Sheikh, David A Palma, George B Rodrigues, A Rashid Dar, Edward Yu, Brian Dingle, Mark Landis, Walter Kocha, Michael Sanatani, Mark Vincent, Jawaid Younus, Sara Kuruvilla, Stewart Gaede, Grace Parraga…
    Citation: BMC Cancer 2014 14:934
    Content type: Study protocol Published on:

  30. Recently, with the access of low toxicity biological and targeted therapies, evidence of the existence of a long-term survival subpopulation of cancer patients is appearing. We have studied an unselected popul...

    Authors: Lizet Sanchez, Patricia Lorenzo-Luaces, Carmen Viada, Yaima Galan, Javier Ballesteros, Tania Crombet and Agustin Lage
    Citation: BMC Cancer 2014 14:933
    Content type: Research article Published on:

  31. Long non-coding RNAs have been shown to have critical regulatory roles in cancer biology. However, the contributions of lncRNAs to gastric cancer remain largely unknown.

    Authors: Yuehua Han, Jun Ye, Dang Wu, Pin Wu, Zhigang Chen, Jian Chen, Shunliang Gao and Jian Huang
    Citation: BMC Cancer 2014 14:932
    Content type: Research article Published on:

  32. It is unclear whether patients with few cerebral metastases benefit from whole-brain irradiation added to radiosurgery. Since primary tumors disseminating to the brain show different behavior, this question sh...

    Authors: Dirk Rades, Stefan Huttenlocher, Dagmar Hornung, Oliver Blanck and Steven E Schild
    Citation: BMC Cancer 2014 14:931
    Content type: Research article Published on:

  34. Despite the preclinical outcomes and biologic significance of the presence of the human epidermal growth factor receptor-2 (HER2) extracellular domain (ECD), there is little evidence supporting the measurement...

    Authors: Sae Byul Lee, Jong Won Lee, Jong Han Yu, Beom Seok Ko, Hee Jeong Kim, Byung Ho Son, Gyungyub Gong, Hee Jin Lee, Sung-Bae Kim, Kyung Hae Jung, Jin-Hee Ahn, Woochang Lee, Joohon Sung and Sei-Hyun Ahn
    Citation: BMC Cancer 2014 14:929
    Content type: Research article Published on:

  35. Amyloid-β precursor protein (APP) is a highly conserved single transmembrane protein that has been linked to Alzheimer disease. Recently, the increased expression of APP in multiple types of cancers has been r...

    Authors: Seunghwan Lim, Byoung Kwon Yoo, Hae-Suk Kim, Hannah L Gilmore, Yonghun Lee, Hyun-pil Lee, Seong-Jin Kim, John Letterio and Hyoung-gon Lee
    Citation: BMC Cancer 2014 14:928
    Content type: Research article Published on:

  36. Disparities by race and neighborhood socioeconomic status exist for many colorectal cancer (CRC) outcomes, including screening use and mortality. We used population-based data to determine if disparities also ...

    Authors: Sandi L Pruitt, Nicholas O Davidson, Samir Gupta, Yan Yan and Mario Schootman
    Citation: BMC Cancer 2014 14:927
    Content type: Research article Published on:

  37. Obesity is a risk factor for cancer incidence and survival, but data on patterns of weight change in cancer survivors are scarce and few stratify by pre-diagnosis weight status. In two population-based cohorts...

    Authors: Sarah E Jackson, Kate Williams, Andrew Steptoe and Jane Wardle
    Citation: BMC Cancer 2014 14:926
    Content type: Research article Published on:

  38. FUSE binding protein1 (FBP1) is a transactivator of transcription of human c-myc proto-oncogene and expressed mainly in undifferentiated cells. It is also present in differentiated normal cells albeit with very l...

    Authors: Updesh Dixit, Zhihe Liu, Ashutosh K Pandey, Ramesh Kothari and Virendra N Pandey
    Citation: BMC Cancer 2014 14:925
    Content type: Research article Published on:

  39. Trastuzumab was registered in 2000 for the treatment of metastatic breast cancer, both as monotherapy and combination therapy with paclitaxel. In this prospective, non-interventional observation study, the 10-...

    Authors: Christian Jackisch, Winfried Schoenegg, Dietmar Reichert, Manfred Welslau, Johannes Selbach, Hanns-Detlev Harich, Hans Tesch, Tim Wohlfarth, Heidi Eustermann and Axel Hinke
    Citation: BMC Cancer 2014 14:924
    Content type: Research article Published on:

  40. Glioblastoma (GBM) is the most common primary brain tumor and the most aggressive glial tumor. This tumor is highly heterogeneous, angiogenic, and insensitive to radio- and chemotherapy. Here we have investiga...

    Authors: Celina Garcia, Luiz Gustavo Dubois, Anna Lenice Xavier, Luiz Henrique Geraldo, Anna Carolina Carvalho da Fonseca, Ana Helena Correia, Fernanda Meirelles, Grasiella Ventura, Luciana Romão, Nathalie Henriques Silva Canedo, Jorge Marcondes de Souza, João Ricardo Lacerda de Menezes, Vivaldo Moura-Neto, Fernanda Tovar-Moll and Flavia Regina Souza Lima
    Citation: BMC Cancer 2014 14:923
    Content type: Technical advance Published on:

  41. In diagnostic pathology, HER2 status is determined in interphase nuclei by fluorescence in situ hybridization (FISH) with probes for the HER2 gene and for the chromosome 17 centromere (CEP17). The latter probe is...

    Authors: Milena Rondón-Lagos, Ludovica Verdun Di Cantogno, Nelson Rangel, Teresa Mele, Sandra R Ramírez-Clavijo, Giorgio Scagliotti, Caterina Marchiò and Anna Sapino
    Citation: BMC Cancer 2014 14:922
    Content type: Research article Published on:

  42. There is evidence that calcium (Ca2+) increases the proliferation of human advanced prostate cancer (PCa) cells but the ion channels involved are not fully understood. Here, we investigated the correlation betwee...

    Authors: Maria Beatrice Morelli, Consuelo Amantini, Massimo Nabissi, Sonia Liberati, Claudio Cardinali, Valerio Farfariello, Daniele Tomassoni, Wilma Quaglia, Alessandro Piergentili, Alessandro Bonifazi, Fabio Del Bello, Matteo Santoni, Gabriele Mammana, Lucilla Servi, Alessandra Filosa, Angela Gismondi…
    Citation: BMC Cancer 2014 14:921
    Content type: Research article Published on:

  43. Human Hematopoietic Signal peptide-containing Secreted 1 (hHSS1) is a truly novel protein, defining a new class of secreted factors. We have previously reported that ectopic overexpression of hHSS1 has a negative...

    Authors: Katiana S Junes-Gill, Chris E Lawrence, Christopher J Wheeler, Ryan Cordner, Tristan G Gill, Vernon Mar, Liron Shiri and Lena A Basile
    Citation: BMC Cancer 2014 14:920
    Content type: Research article Published on:

  44. Exercise has favorable effects on biomarkers associated with a lower risk of breast cancer, however it is unclear if higher doses of exercise provide additional effects. No clinical trial has systematically ex...

    Authors: Christine M Friedenreich, Sarah MacLaughlin, Heather K Neilson, Frank Z Stanczyk, Yutaka Yasui, Aalo Duha, Brigid M Lynch, Ciara Kallal and Kerry S Courneya
    Citation: BMC Cancer 2014 14:919
    Content type: Study protocol Published on:

  45. Standard chemotherapy in unresectable biliary tract carcinoma (BTC) patients is based on gemcitabine combined with platinum derivatives. However, primary or acquired resistance is inevitable and no second-line...

    Authors: Caterina Peraldo-Neia, Giuliana Cavalloni, Marco Soster, Loretta Gammaitoni, Serena Marchiò, Francesco Sassi, Livio Trusolino, Andrea Bertotti, Enzo Medico, Lorenzo Capussotti, Massimo Aglietta and Francesco Leone
    Citation: BMC Cancer 2014 14:918
    Content type: Research article Published on:

  46. MicroRNAs are endogenous non-coding RNAs that play important roles in a wide variety of biological processes such as apoptosis, development, aging and cancer. The aberrant expression of miRNAs may contribute t...

    Authors: Rui Yang, Yongjun Chen, Cong Tang, Hongbo Li, Bing Wang, Qun Yan, Junbo Hu and Shengquan Zou
    Citation: BMC Cancer 2014 14:917
    Content type: Research article Published on:

  47. The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on pri...

    Authors: Lev Stimmer, Sabrina Dehay, Fariba Nemati, Gerald Massonnet, Sophie Richon, Didier Decaudin, Jerzy Klijanienko and Ludger Johannes
    Citation: BMC Cancer 2014 14:916
    Content type: Research article Published on:

  48. Carfilzomib is a selective proteasome inhibitor approved in the United States in 2012 for the treatment of relapsed and refractory multiple myeloma. Although cardiopulmonary and vascular events have been repor...

    Authors: Ajai Chari and Daher Hajje
    Citation: BMC Cancer 2014 14:915
    Content type: Research article Published on:

  49. Papillary thyroid cancer (PTC) often presents as multifocal. However, the association of multifocality with poor prognosis remains controversial. The aim of this retrospective study was to identify the charact...

    Authors: Ning Qu, Ling Zhang, Qing-hai Ji, Yong-xue Zhu, Zhuo-ying Wang, Qiang Shen, Yu Wang and Duan-shu Li
    Citation: BMC Cancer 2014 14:914
    Content type: Research article Published on:

  50. Hepatocellular carcinoma (HCC) is one of the most common malignancies and a major cause of cancer-related mortality in the world. MicroRNAs (miRNAs) are small, noncoding RNAs that play essential roles in vario...

    Authors: Xue-Wei Yang, Guan-Zhu Shen, Liang-Qi Cao, Xiao-Feng Jiang, He-Ping Peng, Gang Shen, De Chen and Ping Xue
    Citation: BMC Cancer 2014 14:909
    Content type: Research article Published on:

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