Impact of chemotherapy cycles and intervals on outcomes of nonspinal Ewing sarcoma in adults: a real-world experience
BMC Cancer volume 19, Article number: 1168 (2019)
Adult Ewing sarcoma (ES) is a rare disease, the optimal treatment model is unknown. This study aimed to retrospectively analyze treatment-related prognostic factors of nonspinal ES in Chinese adults.
Eighty-one patients treated between January 2005 and December 2017 were included in the present study. Thirty-three (40.7%) presented with metastatic disease at diagnosis. Eight patients were submitted to primary surgery followed by chemotherapy, while 73 patients received chemotherapy before and after surgery and/or local radiotherapy. The chemotherapy regimen included 8–17 cycles of vincristine, doxorubicin, and cyclophosphamide (VDC) alternating with ifosfamide and etoposide (IE) every 3 weeks. Clinical outcomes and safety were analyzed.
VDC/IE chemotherapy was well tolerated in adult patients with ES. Multivariate Cox regression analyses revealed that chemotherapy of at least 12 cycles was a favorable independent prognostic factor of event-free survival (hazard ratio, 0.558; 95% confidence interval, 0.323–0.965; P = 0.037) and overall survival (hazard ratio, 0.424; 95% confidence interval, 0.240–0.748; P = 0.003). Similarly, a low frequency of chemotherapy delays was an independent prognostic factor of improved OS (hazard ratio, 0.438; 95% confidence interval, 0.217–0.887; P = 0.022).
Our study suggests that adults with ES should be treated with an aggressive multidisciplinary approach, intensive chemotherapy with adequate cycles and appropriate intervals can be recommended in this group.
Ewing sarcoma (ES) is the second most common primary bone malignancy in children, but is extremely rare in adults [1,2,3]. The treatment of ES relies on a multidisciplinary approach that couples risk-adapted chemotherapy and local therapy (surgery, radiation therapy, or both). Chemotherapy plays a pivotal role in the treatment of ES. The regimen including vincristine, doxorubicin, and cyclophosphamide (VDC) alternating with ifosfamide and etoposide (IE) is a category 1 recommendation for ES in NCCN guideline . However, there is no consensus on the optimal chemotherapy cycles and intervals. It was reported that VDC/IE every 3 weeks for 14 cycles contributed to similar survival compared with the same protocol for 17 cycles . VDC/IE given at a 2-week interval was found to be more effective than VDC/IE given at a 3-week interval , but the NCCN panel only recommends this 2-week compressed treatment in patients younger than 18 years.
As far as ES in adults is concerned, the optimal chemotherapy regimen remains unknown because current chemotherapy regimens are derived from clinical trials done in a predominantly pediatric population [5,6,7,8,9]. No prospective studies have been performed exclusively in adult ES because of the rarity of the diagnosis. It is not clear whether the pediatric regimens truly apply to adults . The tolerability and efficacy of chemotherapy in older patients should be taken into account when extrapolating the protocols to adults [3, 11]. On the other hand, previous clinical trials in ES were usually conducted in Europe and North America [2, 5,6,7,8,9, 12,13,14], and were rarely done in Asian countries. There are racial disparities in incidences of ES [15, 16], it is pending whether its response to treatment and prognosis also differ among races. In the present study, we retrospectively reviewed the data of adult ES treated by the same multidisciplinary team over 10 years in China. This study aimed to analyze chemotherapy-related factors that affected outcomes of this rare disease. To our knowledge, this is the largest study on adult ES from Asia. Primary ES of the spine was excluded in our cohort because it has special characteristics and prognostic factors .
This study was approved by the local ethics committee, informed consent was waived due to the retrospective nature of the study. Between January 2005 and December 2017, 87 adult patients with nonspinal ES were treated by the same multidisciplinary team in our center (Table 1). However, 6 patients were excluded either because of insufficient follow-up data or evidence of disease progression before completing first-line therapy. All 81 patients enrolled in the present study had histopathologically diagnosed ES, which met the diagnostic criteria described previously . Evaluation for translocation t (11; 22) (q24; q12) was not required to be enrolled in the study, it was performed in 39 patients. Initial staging procedures consisted of bone marrow biopsies and imaging studies. Imaging studies included X-rays, ultrasonic inspection, computed tomography and magnetic resonance imaging (MRI) of the primary tumor, a chest computed tomography scan, a bone scan or positron emission tomography.
All patients received chemotherapy according to regimen described previously . The regimen included vincristine (1.4 mg/m2 on day 1, maximum 2 mg), doxorubicin (75 mg/m2 on day 1), and cyclophosphamide (1.2 g/m2 on day 1) (VDC) alternating with ifosfamide (1.8 g/m2/day, days 1–5) and etoposide (100 mg/m2/day, days 1–5) (IE) every 3 weeks. When patients had received a cumulative doxorubicin dose of 300 mg/m2, dexrazoxane was administrated for cardioprotective purpose before each dose of doxorubicin at 10:1 dose ratio since 2012. Doxorubicin was replaced by actinomycin D (1.25 mg/m2) after reaching a cumulative dose of 450 mg/m2 or couldn’t been tolerated by patients. Patients had a full blood test on the day prior to the cycle due date and chemotherapy was given if the neutrophil count was greater than 1.5 × 109/L, platelet count greater than 80 × 109/L and biochemical parameters were within normal range. Otherwise, chemotherapy would be delayed until hematological recovery. As a routine, sustained grade 3–4 neutropenia for > 3 days or neutropenic fever was an indication of dose reduction in the present study. Granulocyte colony-stimulating factor prophylaxis was recommended to avoid new episodes of neutropenia and delay of subsequent courses.
The timing and form of local therapy was at the discretion of the multidisciplinary treating team. Whenever possible, surgery was recommended for local treatment. If it was not feasible or not preferred by the patient, definitive radiotherapy would be performed. Indications for postoperative radiotherapy included gross residual disease and positive or close resection margins. The radiotherapy was delivered as previously described .
A database was designed to retrospectively collect data on baseline demographic characteristics, treatment modalities, and clinical outcomes. Chemotherapy toxicity was reported according to the Common Terminology Criteria for Adverse Events version 4.0. Chemotherapy given > 3 days later than the cycle due date was defined as a chemotherapy delay. Time to local therapy was defined as the time from the initiation of any treatment to local therapy. If a patient received both surgery and radiotherapy, the date of local therapy was defined by whichever occurred first. Event-free survival (EFS) was defined as the time from diagnosis to disease recurrence, progression, second malignancy, death from any cause, or last contact. Overall survival (OS) was defined as the interval between diagnosis and death from any cause or the most recent follow-up. Clinical responses were classified as complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD) according to response evaluation criteria in solid tumors for the soft-tissue component of the primary lesion as well as non-osseous metastases . Missing data were collected from patients or their family members by telephone. Information regarding treatment at recurrence was not collected.
All analyses were performed using Statistical Package for the Social Sciences (SPSS), version 18.0 (Chicago, Illinois, USA). Continuous variables were presented as mean ± SD. Qualitative variables were shown as absolute and relative frequencies. The χ2 or Fisher’s exact test was used to compare proportions. Kaplan-Meier survival curves were used to estimate proportion surviving and the log-rank test was used to compare differences among subgroups. Cox regression models were used to identify independent prognostic factors. If variables were significant at the 0.1 level on univariate analysis, then they were included in the multiple regression. A P value < 0.05 was considered significant.
This study consisted of 81 patients (56 males, 25 females), with a mean age of 31.0 ± 9.4 years (range 18–63 years) at diagnosis. Forty-nine patients (60.5%) were < 30 years of age, whereas 32 patients (39.5%) were ≥ 30 years. The primary tumors were skeletal in 57 (70.4%) patients, while 24 (29.6%) had extraskeletal disease. Twenty-five patients had extremity-based tumors, including those in the lower (n = 17) and upper (n = 8) extremities. 56 patients had trunk-based tumors, including those in the pelvic girdle (n = 23), in the thorax (n = 17), at head and neck (n = 9), and in abdomen and hip (n = 7). The diameter of primary lesion was < 8 cm in 50 cases and ≥ 8 cm in 31 patients. Among all 81 patients, 48 (59.3%) patients presented with localized disease, 33 (40.7%) patients presented with metastatic disease (14 with lung metastases, 10 with bone metastases, 1 with lymphonode metastases, 7 with both lung and bone metastases, 1 with simultaneous bone and bone marrow metastases) at diagnosis (Table 1).
All patients received chemotherapy, 8 after local treatment and 73 as neoadjuvant and adjuvant therapies. The median number of cycles received per patient was 12 (range, 8 to 17). For the 8 patients who received chemotherapy after local treatment, primary surgery was performed for curative purpose because the treating surgeon did not suspect the presence of ES. Among the remaining 73 patients, 27 patients underwent surgery of the primary tumors as local therapy, 18 patients received radiotherapy alone, and 28 patients received both. Overall, the median time to local therapy was 3.2 months (range, 0–7 months).
The clinical response in all 73 patients who underwent neoadjuvant chemotherapy included 19 CRs, 37 PRs and 17 SDs, with an overall response rate of 76.7%. Pathologic evaluation of chemotherapy-related tumor necrosis was available for 45 patients who received neoadjuvant chemotherapy; good response (necrosis of ≥90% of the resected specimen) was observed in 20/32 (62.5%) patients with skeletal tumor and in 6/13 (46.2%) patients with extraskeletal disease.
The median follow-up in this cohort was 36 months (range, 11–120 months). Local relapses occurred in 23 patients, 7 of them had undergone exclusive surgery as local therapy, 6 of them had received radiation as local therapy, and the other 8 patients had received combined surgery and radiotherapy, the incidences of local relapses in these three subgroups were similar (P > 0.05). Among the 23 patients with local relapses, 10 presented simultaneous metastatic relapses (including metastatic progression) and 13 delayed metastatic relapses. Thirty patients experienced isolated metastatic relapse as a first oncological event. Local and metastatic relapses occurred within a median interval of 23 months (range, 11–49 months). Overall, the 5-year EFS was 22.0%. Fifty-two patients died of disease progression, no death from any other cause occurred, leading to a 5-year OS of 33.0%.
Drug toxicities to the hematologic system, liver, kidneys, heart, bladder, mucosa and peripheral nerve were observed during chemotherapy. Grade 3–4 neutropenia was reported in 77 patients (95.1%), grade 3–4 thrombocytopenia in 45 patients (55.6%). Red blood cells or platelets transfusions were needed in 13 (16.0%) and 9 (11.1%) patients, respectively. Peripheral neurologic toxicity occurred in 10 patients; one patient discontinued vincristine early due to grade 3 neurologic toxicity. Toxicity-related dose reduction occurred in 48 patients (59.3%) (Table 2). Forty-two patients (51.8%) had at least one chemotherapy delay, while 16 patients had chemotherapy delays in more than 25% cycles. The major cause of chemotherapy delays was chemotherapy toxicity (87.9%), other reasons accounted for 12.1%. Notably, frequencies of dose reduction were similar in the two patient subgroups who received chemotherapy more or less than 12 cycles (65.9% vs. 52.5%, P > 0.05), so the number of chemotherapy cycles positively correlated with the total chemotherapy doses and the frequencies of chemotherapy delays positively correlated with chemotherapy intervals.
Analysis of prognostic factors of survival
Univariable analysis showed that stage (P = 0.071) and number of chemotherapy cycles (P = 0.058) showed a trend toward significance for EFS. These two factors were submitted to multivariable analysis. The results showed that both localized disease at diagnosis (P = 0.045) and chemotherapy of at least 12 cycles (P = 0.037) were favorable independent prognostic factors of EFS (Table 3). As far as OS was concerned, univariable analysis showed that stage (P = 0.004) and number of chemotherapy cycles (P = 0.015) were significantly associated with OS. These two factors along with frequency of chemotherapy delays (P = 0.076) were submitted to multivariable analysis. Multivariable analysis showed that all these three factors were significant predictors of OS (Table 4). Chemotherapy of at least 12 cycles was associated with both improved EFS and OS in the present study (Fig. 1). Stratified analyses indicated that frequency of chemotherapy delays didn’t affect EFS significantly (log-rank test, P = 0.364). However, a low frequency of chemotherapy delays (< 25%) was a favorable independent predictor of OS in our patients (P = 0.022).
At present, no standard treatment model has established for adult ES and the management is often institution-specific [19,20,21,22]. Even for the most commonly used VDC/IE chemotherapy regimen, the number of cycles ranges from 6 to 17 in different studies [5, 22, 23]. The optimal chemotherapy regimen for adult ES is controversial . Tao et al. reported that there were no significant differences between anthracycline and platinum based chemotherapy regarding EFS and OS . In contrast, Casey et al. and Ahmed et al. reported that treatment according to the pediatric protocol was significantly associated with improved survival [21, 24]. In the present cohort, we also followed the pediatric VDC/IE protocol, unfortunately 50 patients didn’t completed the planned 17 chemotherapy cycles due to various reasons: the most common reason was lack of money (21 patients, 42%), followed by the belief that adults inevitably fare worse than children and increasing chemotherapy duration may not lead to improvement in survival (16 patients, 32%), toxicity-related treatment abandonment occurred in eight patients (16%), and other reasons accounted for five patients (10%). Overall, VDC/IE chemotherapy was well tolerated in our patients. Our study provided real-world data in adult ES from Asian developing countries, and the aforementioned situation provided an opportunity for comparative analysis between different chemotherapy cycles and intervals.
It was reported that adult patients with ES had a worse prognosis compared to pediatric patients [5, 9, 23, 25,26,27]. As far as nonmetastatic ES was concerned, Granowetter et al. reported that the 5-year EFS was 77.5% for patients age 1 to 9 years, 69.4% for patients age 10 to 17 years, and 63.2% for patients older than 18 years . Womer et al. reported that the 5-year EFS was 72 and 47% for patients younger and older than 18 years, respectively . In the present study, we also observed a poor prognosis for adult ES, with a 5-year OS of 33.0% and EFS of only 22.0%. The reasons behind the poor prognosis for adult ES are unclear. Generally, the prognostic factors of ES include site of primary disease, tumor volume, response to chemotherapy, and presence of metastatic disease at diagnosis [12, 13, 28]. It is not clear if these findings from pediatric studies also apply to adults because several case series suggested that ES in adult populations was a more biologically aggressive variant of the disease [3, 27]. However, there is a uniform consensus that patients presenting with metastatic disease have an extremely poor prognosis, regardless of age. In our cohort, 40.7% of patients presented with metastatic disease at diagnosis, slightly more compared with other series [24, 29, 30], this may partially justify the dismal survival. When patients with metastatic disease at presentation were excluded, the 5-year OS and EFS increased to 44.0 and 31% for the remaining 48 patients in the present study. Notsurprisingly, this outcome was worse than that of aforementioned pediatric patients with localized ES [5, 9]. However, these figures were still fewer than those from other recent adult cohorts: OS of 66% and EFS of 44.0% in the Casey et al. series of 76 cases , OS of 66% and EFS of 43.0% in the Fizazi et al. series of 129 cases .
To identify the factors that potentially affect the outcomes of our cohort, we conducted exploratory univariable and multivariable analyses. Interestingly, besides metastatic disease at diagnosis, chemotherapy of less than 12 cycles was also detrimental to both OS and EFS of our patients. Moreover, a high frequency of chemotherapy delays (≥ 25%) was an unfavorable independent predictor of OS. As mentioned above, the number of chemotherapy cycles positively correlated with the chemotherapy doses and the frequencies of chemotherapy delays positively correlated with chemotherapy intervals. These findings suggested that the poor prognosis in the present study was partially due to insufficient chemotherapy doses and prolonged dose intervals. Dose-dense chemotherapy with shortening intervals showed an increase in survival of ES , whereas the benefit of dose escalation (increasing the dose of chemotherapy agents) studies has been less consistent and may be accompanied by other dose-limiting toxicities . It was reported that lower doses of alkylating agents were detrimental to survival of ES , however, dose escalation of alkylating agents in the VDC/IE regimen did not improve the outcome for patients with localized disease . Based on our results, we strongly recommend aggressive treatment for adult ES to maintain adequate chemotherapy doses and appropriate intervals, with the help of supportive treatment. None of the other factors such as extremity/axial primary site, skeletal/extraskeletal tumor origin, diameter of primary tumor, local therapy modality and time to local therapy achieved statistical significance, but age older than 30 years at diagnosis (HR 1.45, P = 0.183) showed a trend toward significance for OS. Although chemotherapy cycles and intervals can be affected by chemotherapy toxicity, the univariable analysis indicated that grade 3–4 chemotherapy toxicity didn’t affect the EFS and OS of our patients significantly.
To further explore the potential racial disparity in survival of adult ES, we reviewed the outcomes of localized disease treated with similar cycles of VDC/IE regimen (Table 5). The prognosis of our patients was better than that of Canadian series, while it was a little worse than the prognosis of cohorts from the USA and Turkey. The results showed no evidence of ethnical disparity in survival of adult ES. Further head-to-head comparative studies are needed to clarify this question.
Patients who receive high doses of anthracyclines are at risk for cardiotoxicity, dexrazoxane is often used as a cardioprotectant when prior doxorubicin reached a cumulative dose of 300 mg/m2 . But controversy exists if dexrazoxane reduces the antitumor effect of doxorubicin and increases the risk of second primary malignancies . In the present study, we found that there were no differences of EFS and OS in patients with or without administration of dexrazoxane (log-rank test, P > 0.05), and there was no second primary malignancy occurred during the follow-up period. Our results were consistent with the findings from other recent large population-based studies [32, 34, 35].
This study has several limitations. First, it was a retrospective, single-institution study with a small sample size. As a consequence, it was difficult to draw conclusions on all factors influencing outcomes. Second, we excluded patients for whom there was incomplete clinical data or evidence of disease progression before completing first-line therapy. This could have resulted in selection bias. To assess accurately the outcomes and prognostic factors of adult ES, large prospective clinical trials are needed.
The present study shows that VDC/IE chemotherapy is well tolerated in adult patients with ES, chemotherapy of at least 12 cycles is associated with better EFS and OS compared with less cycles of chemotherapy. Similarly, a low frequency of chemotherapy delays is an independent prognostic factor of improved OS. Our findings suggest that adults with ES should be treated with an aggressive multidisciplinary approach, intensive chemotherapy with adequate doses and appropriate intervals can be recommended in this group when the toxicity was tolerable.
Availability of data and materials
The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Ifosfamide and etoposide
Magnetic resonance imaging
The National Comprehensive Cancer Network
Statistical Package for the Social Sciences
Vincristine, doxorubicin, and cyclophosphamide
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This work was supported by grants from the National Natural Science Foundation of China (No. 81503396), the National Key Research Project of Science and Technology Ministry (No. 2016YFC0106204), the Shanghai Senior Integrative Chinese and Western Medicine Talents Program (No. ZY(2018–2020)-RCPY-2017) and the Pujiang Talent Project (No. 17PJ1407600). The funding facilitated the collection, analysis, and interpretation of the data and the writing of the manuscript.
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Zhang, J., Huang, Y., Sun, Y. et al. Impact of chemotherapy cycles and intervals on outcomes of nonspinal Ewing sarcoma in adults: a real-world experience. BMC Cancer 19, 1168 (2019). https://doi.org/10.1186/s12885-019-6407-5